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Steven Rothenberg
PURPOSE: Thoracoscopic lobectomy for congenital cystic lung disease has become an accepted and in many institutions the preferred technique. However, the technical challenges are many. Previous endoscopic staplers (12 mm) used commonly in adults are too large for use in infants This study evaluates the safety and efficacy of using a 5 mm stapling device to seal and divide major pulmonary structures. METHODS: From July 2014 to March 2016, 26 patients of age 6 weeks to 13 months underwent thoracoscopic lobectomy for CPAM or sequestration...
October 5, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Stephen Sf Yip, John Kim, Thibaud Coroller, Chintan Parmar, Emmanuel Rios Velazquez, Elizabeth Huynh, Raymond Mak, Hugo Jwl Aerts
PURPOSE: Positron emission tomography (PET)-based radiomics has been used to non-invasively quantify the metabolic tumor phenotypes; however, little is known about the relationship between these phenotypes and underlying somatic mutations. This study assessed the association and predictive power of (18)F-FDG-PET-based radiomic features for somatic mutations in non-small cell lung cancer (NSCLC) patients. METHODS: 348 NSCLC patients underwent diagnostic (18)F-FDG-PET/CT scans and were tested for genetic mutations...
September 29, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Sophie Liabeuf, Kamel Masmoudi, Lucie-Marie Scailteux, Julien Moragny, Henri Masson, Valérie Brnet-Dufour, Michel Andrejak, Valérie Gras-Champel
Although drug therapy is inherently associated with the risk of adverse drug reactions (ADRs), some of these events are preventable. The estimated proportion of preventable ADRs varies from one study or clinical context to another. Bleeding caused by antithrombotic agents (and particularly vitamin K antagonists, VKAs) constitutes one of the most frequent causes of ADR-related hospitalization.Hence, the objective of the present study was to adapt and validate an ADR preventability score for bleeding due to VKAs and evaluate the preventability of bleeding in 906 consecutive hospitalized, VKA-treated adult patients with a risk of major bleeding (defined as an international normalized ratio ≥5) over a 2-year period...
September 2016: Medicine (Baltimore)
Laila Mahir, Siham Zahi, Karima Belhaj, Fatima Lmidmani, Abdellatif El Fatimi
OBJECTIVE: The isokinetic allows precise and reproducible measurement of muscle strength in the normal state and in various pathological contexts. Its use in neurological diseases is limited, despite its vast scope. To report the profile isokinetic knee during the decisive cauda equina syndrome as a buoyant building program, through 2 comments. OBSERVATIONS: Observation 1: patient aged 58 years, without particular pathological ATCDS, which has a cauda equina syndrome of herniated disc L4/L5 made...
September 2016: Annals of Physical and Rehabilitation Medicine
(no author information available yet)
Of the 26 contributors to Assessing Interventions: Traditional and Innovative Methods, Volume 4, there is only one nursing contributor; the majority of the remainder being medical doctors from the USA. Of the 246 pages, just nine are used by the nurse contributor, who says little that is new about qualitative methods in researching nursing care. The book needs to be read with the primary health-care team in mind.. It is divided into four sections. Section One considers basic issues in assessing interventions in primary care; the second section looks at the application of alternative methodologies - quantitative and qualitative...
March 3, 1993: Nursing Standard
Simon M Bell, Basil Sharrack, John A Snowden
Autologous haematopoietic cell transplantation (AHCT) is an evolving treatment avenue in multiple sclerosis (MS), which may be highly effective in controlling disease activity and improving disability. However, AHCT is associated with intrinsic toxicities and risks compared with conventional therapies. With growing experience in patient selection and treatment delivery, AHCT is increasingly considered an option in patients with aggressive disease that's responding poorly to disease modifying therapy. Areas covered: This article provides an introduction to AHCT and looks at its development as a treatment for MS over the last 20 years...
October 14, 2016: Expert Opinion on Biological Therapy
Xin-Gui Peng, Yingying Bai, Judy R James, Darya P Shlapak, Shenghong Ju
Endothelial progenitor cells (EPCs) play an important role in repairing ischemia tissues. Diffusion tensor imaging (DTI) was applied to detect the architectural organization of skeletal muscle. This study investigated the feasibility and accuracy of using the DTI to evaluate effectiveness of EPCs treatment. Mouse bone marrow-derived EPCs were isolated, cultured, characterized, and transplanted to hindlimb ischemia mice model. DTI was performed on the hindlimb at postischemia time points. The edema regions of diffusion restriction (high signal in diffusion weighted imaging) were decreased in the ischemic muscle of EPCs treated mice after 14 days compared with the controls...
2016: Stem Cells International
Steven A Newman, Roger E Turbin, Mary E Bodach, Luis M Tumialan, Nelson M Oyesiku, Zachary Litvack, Gabriel Zada, Chirag G Patil, Manish K Aghi
BACKGROUND: Nonfunctioning pituitary adenomas (NFPAs) are the most frequent pituitary tumors. Visual symptoms from NFPAs are common and include visual field defects, loss of central vision, and motility problems resulting in diplopia. OBJECTIVE: To create evidence-based guidelines in an attempt to formulate guidance for preoperative ophthalmologic evaluation of NFPA patients. METHODS: An extensive literature search was performed. Only clinical articles describing preoperative ophthalmologic evaluation of adult patients with NFPA were included...
October 2016: Neurosurgery
J M Pardal-Fernandez, S Ezsol-Lendvai, M Rodriguez-Vazquez, J L Agudo-Mena, B Godes-Medrano
INTRODUCTION: Leprosy is an infectious disease caused by the bacteria Mycobacterium leprae. It is particularly prone to affect the skin and the nerve trunks and, in fact, both are compromised in most infected patients. It is transmitted by exposure to those with the disease and sometimes by reactivation. One uncommon possibility is pure neural leprosy, which is characterised by neuropathy, but without skin lesions. We report the case of a patient with pure neural leprosy and review the diagnostic aspects...
September 16, 2016: Revista de Neurologia
Ismail Yağmur, Burak Turna, Ali Tekin, Emir Akıncıoğlu, Bnu Sarsık, İbrahim Ulman
INTRODUCTION: Benign prostatic hyperplasia (BPH) is generally common in men older than 50 years of age but is extremely rare in childhood. In the literature to date, fewer than five cases have been reported under 18 years of age. Owing to the limited number of cases, the etiology and management of BPH in the first two decades is not clear. OBJECTIVE: We herein report a 17-year-old boy who presented with acute urinary retention due to BPH and was treated with endoscopic transurethral resection of the prostate (TUR-P)...
August 2016: Journal of Pediatric Urology
Virginia Harrison, Sarah Mackenzie Ross
Previous research suggests that individuals with a prior history of pesticide poisoning are at increased risk of psychiatric disorder (Freire and Koifman, 2013), but findings regarding the impact of cumulative low-level exposure are inconsistent. The aim of the current study was to investigate whether sheep farmers with a history of low-level exposure to organophosphate pesticides (1) report a higher level of psychological distress on subjective symptom questionnaires, compared to unexposed controls (2) also meet internationally agreed diagnostic criteria for a psychiatric disorder more often than unexposed controls...
August 26, 2016: Environmental Research
Ke Zu, Ge Tao, Julie E Goodman
BACKGROUND: In the 2014 Integrated Risk Information System (IRIS) assessment for Libby amphibole asbestos (LAA), US EPA calculated a reference concentration (RfC) based on the prevalence of pleural plaques in a group of vermiculite workers in Marysville, Ohio. This RfC is based on the assumption that pleural plaques are associated with adverse lung function. In this study, we evaluated the association between pleural plaques and lung function in the Marysville worker cohort to determine whether they are associated with adverse effects or, rather, are more likely a biomarker of cumulative exposure to LAA...
September 2016: Inhalation Toxicology
Michael J Delves, Ursula Straschil, Andrea Ruecker, Celia Miguel-Blanco, Sara Marques, Jake Baum, Robert E Sinden
The prevention of parasite transmission from the human host to the mosquito has been recognized as a vital tool for malaria eradication campaigns. However, transmission-blocking antimalarial drug and/or vaccine discovery and development is currently hampered by the expense and difficulty of producing mature Plasmodium falciparum gametocytes in vitro-the parasite stage responsible for mosquito infection. Current protocols for P. falciparum gametocyte culture usually require complex parasite synchronization and addition of stimulating and/or inhibitory factors, and they may not have demonstrated the essential property of mosquito infectivity...
September 2016: Nature Protocols
Jorge de Abajo, Raquel Manrique-Huarte, Ignacio Sanhueza, Laura Alvarez-Gómez, Cristina Zulueta-Santos, Diego Calavia, Fernando Ramírez, Manuel Manrique
OBJECTIVES: The objectives of this study were to evaluate the effect of reimplanting a cochlear implant electrode in animal normal-hearing cochlea to propose measures that may prevent cochlear injury and, given its close phylogenetic proximity to humans, to evaluate the macaque as a model for electroacoustic stimulation. DESIGN: Simultaneous, bilateral surgical procedures in a group of 5 normal-hearing specimens (Macaca fascicularis) took place in a total of 10 ears...
August 22, 2016: Ear and Hearing
E Duron, J S Vidal, F Roca, L Caillard, E Chaussade, S Chauvelier, H Rananja, C Boully, A S Rigaud, O Hanon
OBJECTIVE: HASH(0x46500c8) BACKGROUND: Orthostatic hypotension (OH) is associated with falls and mortality in the elderly. Self-measurement of blood pressure (SMBP) is validated to detect hypertension but feasibility and accuracy of self-measurement of orthostatic-hypotension (SMOH) is unknown. OBJECTIVE: To evaluate feasibility and accuracy of SMOH or OH measured by caregiver among elderly subjects with memory complaints. DESIGN AND METHOD: Hundred eighty-five patients attending a Broca's memory clinic, aged >60 years old, able to stand up for >3 minutes and with a Mini Mental State Examination > 25/30 or with a caregiver able to perform standardized BP measurement were included...
September 2016: Journal of Hypertension
Hideki Shigematsu, Tomohiko Kura, Eiichiro Iwata, Akinori Okuda, Yasuhiko Morimoto, Keisuke Masuda, Yasuhito Tanaka
STUDY DESIGN: Retrospective study. OBJECTIVE: The aim of this study was to determine the incidence of increased segmental ROM after laminoplasty and to clarify whether increased ROM is associated with spondylolisthesis. Finally, we explored the effect of increased segmental ROM on clinical results. SUMMARY OF BACKGROUND DATA: Cervical laminoplasty for cervical spondylotic myelopathy causes reduced range of motion (ROM), possibly due to the unintended contracture of the facet joint or a bony union...
August 3, 2016: Spine
Daniel F Arruda-Junior, Flavia L Martins, Rafael Dariolli, Leonardo Jensen, Ednei L Antonio, Leonardo Dos Santos, Paulo J F Tucci, Adriana C C Girardi
Circulating dipeptidyl peptidase IV (DPPIV) activity is associated with worse cardiovascular outcomes in humans and experimental heart failure (HF) models, suggesting that DPPIV may play a role in the pathophysiology of this syndrome. Renal dysfunction is one of the key features of HF, but it remains to be determined whether DPPIV inhibitors are capable of improving cardiorenal function after the onset of HF. Therefore, the present study aimed to test the hypothesis that DPPIV inhibition by vildagliptin improves renal water and salt handling and exerts anti-proteinuric effects in rats with established HF...
2016: Frontiers in Physiology
Jing-Jing Liang, Zhe-Qing Zhang, Ya-Jun Chen, Jin-Cheng Mai, Jun Ma, Wen-Han Yang, Jin Jing
BACKGROUND: Evidence linking caries in primary dentition and children's anthropometric measures is contradictory. We aimed to evaluate the prevalence of primary dental caries and its relationship with body mass index (BMI) among 7-9 years old school children in urban Guangzhou, China. METHODS: This cross-sectional study enrolled 32,461 pupils (14,778 girls and 17,683 boys) aged 7-9 years from 65 elementary schools in Guangzhou. Dental caries was detected according to criteria recommended by the World Health Organization (WHO)...
2016: BMC Public Health
Na Young Kim, Ki-Young Lee, Sun Joon Bai, Jung Hwa Hong, Jinwoo Lee, Jong Min Park, Shin Hyung Kim
Diabetic foot ulcer is the most common cause of diabetes-associated nontraumatic lower extremity amputation. Most patients who undergo lower extremity amputation for a diabetic foot have had diabetes for a long time and suffer from multiorgan disorder; thus, it can be a challenge to ensure sufficient anesthetic and analgesic effects while maintaining stable hemodynamics. Recently, peripheral nerve block has gained popularity owing to its attenuating effects of systemic concerns. This retrospective observational study aimed to compare the effects of remifentanil-based general anesthesia (GEA) and popliteal nerve block (PNB) on postoperative pain and hemodynamic stability in diabetic patients undergoing distal foot amputation...
July 2016: Medicine (Baltimore)
Rebecca J Kamil, Elina Jerschow, Patricia A Loftus, Melin Tan, Marvin P Fried, Richard V Smith, David Foster, Thomas J Ow
OBJECTIVES/HYPOTHESIS: Black race is a risk factor for angioedema. The primary aim was to examine the relationship between race-ethnicity and risk factors for angioedema. STUDY DESIGN: Using a retrospective case-control study design, data was extracted with the Clinical Looking Glass utility, a data collection and management tool that captures data from electronic medical record systems within the Montefiore Healthcare System. Cases were emergency department (ED) visits with primary or secondary International Classification of Diseases, Ninth Revision, code diagnoses of angioedema in adults aged ≥ 18 years from January 2008 to December 2013 at three Montefiore centers in Bronx, New York...
August 2016: Laryngoscope
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