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Kenneth Dahl, Ryuji Nakao, Nahid Amini, Mohammad Mahdi Moein, Sjoerd Finnema, Jonas Malmquist, Katarina Varnäs, Magnus Schou
The histamine subtype-3 receptor (H3 R) is implicated in a range of central nervous system disorders, and several radioligands have been developed for H3 R positron emission tomography imaging. However, a limitation of currently used PET radioligands for H3 R is the slow binding kinetics in high density brain regions. To address this, we herein report the development of three novel candidate H3 R radioligands, namely, [carbonyl-11 C]AZ13153556 ([carbonyl-11 C]4), [carbonyl-11 C]AZD5213([carbonyl-11 C]5), and [carbonyl-11 C]AZ13198083 ([carbonyl-11 C]6), and their subsequent preclinical evaluation in nonhuman primates (NHP)...
January 30, 2018: ACS Chemical Neuroscience
María Luisa Bordejé Laguna
Lung’s own properties make that nutritional support, besides covering the requirements can modulate its infl ammatory response. Lung tissue has a low glucose stock. Fatty acids are the main energy producer of type II pneumocytes, which use them in order to form phospholipids, essential for surfactant whose creation and release decrease in acute lung injury (ALI). Glutamine is a good substratum for endocrine cells and type II pneumocytes. Due to high nutritional risk, it is important its assessments in disorders as COPD and acute respiratory distress syndrome (ADRS)...
May 8, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Thamires de Souza Hilário, Simone Marques Dos Santos, Juliana Kruger, Martha Georgina Goes, Márcia Flores Casco, Eneida Rejane Rabelo-Silva
OBJECTIVE: To describe how pain is assessed (characteristic, location, and intensity) and managed in clinical practice in patients undergoing endovascular procedures in the catheterization laboratory setting. METHOD: Cross-sectional study with retrospective data collection. RESULTS: Overall, 345 patients were included; 116 (34%) experienced post-procedural pain; in 107 (92%), pain characteristics were not recorded; the location of pain was reported in 100% of patients, and its intensity in 111 (96%); management was largely pharmacologic; of the patients who received some type of management (n=71), 42 (59%) underwent reassessment of pain...
May 25, 2017: Revista da Escola de Enfermagem da U S P
Laura A Escalona, Patrizzia Mastromatteo-Alberga, María Correnti
The purpose of the present research was to determine the levels of IL- 1a, IL- 1 P, TNF-a, IL-6, IL-6sR, IL-8, IL-10, MMP-3 and EMP-8 in gingival crevicular fluid (GCF) of subjects with chronic periodontitis. Clinical measurements were carried out in 20 patients with chronic periodontitis and 11 periodontally healthy controls. The clinical indexes evalua- ted were: gingival index (GI), plaque index (PI), bleeding on probing (BOP), probing depth (PD) and clinical attachment loss (CAL); the measurements were taken at six sites per tooth in all teeth in each subject...
June 2016: Investigación Clínica
X W Kang, H Tong, K Q Cao, Q F Mo, L W Li, G L Hong, L Mo, D Li, G J Zhao, Z Q Lu
Objective: To explore prognostic factors of acute paraquat poisoning (APP) , analyze the correlation between base excess (BE) and plasma concentration of paraquat (C-PQ) and discuss BE level in evalua-tion of prognosis of acute paraquat poisoning patients. Methods: We retrospectively selected 84 APP patients who admitted to Emergency Intensive Care Unit (EICU) of our hospital from 2009.9.1 to 2015.8.31.Clinical data from 84 APP patients were analyzed. BE、C-PQ、time of gastric lavagesince ingestion、time of hemoperfusion since ingestion、severity index of paraquat poisoning (SIPP) 、white blood cell (WBC) 、percentage of neutrophils (N%) 、hemoglobin (HB) 、creatinine (Cr) 、alanine aminotransferase (ALT) 、aspartate aminotransferase (AST) 、partial pressure of oxygen (PaO(2)) 、partial pressure of carbon dioxide (PaCO(2)) and other laboratory parameters were measured...
January 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
P A De la Rosa Fernández-Pacheco, J Delfrade Osinaga, Y Floristán Floristán, R Teijeira Alvarez, C Moreno-Iribas
Fundamento. Se analizan las tendencias de la mortalidad por accidentes de transporte entre 1999 y 2013 y se evalúa el impacto de la introducción del permiso de conducción por puntos en Navarra.Material y métodos. Los datos para la realización de este estudio proceden de los ficheros de defunciones según la causa de muerte que anualmente publica el Instituto Nacional de Estadística (INE). La codificación de la causa de defunción se realizó con la CIE-10, a partir de la información de los documentos estadísticos de defunción y los informes forenses...
December 30, 2016: Anales del Sistema Sanitario de Navarra
Karan Uppal, Douglas I Walker, Dean P Jones
Improved analytical technologies and data extraction algorithms enable detection of >10 000 reproducible signals by liquid chromatography-high-resolution mass spectrometry, creating a bottleneck in chemical identification. In principle, measurement of more than one million chemicals would be possible if algorithms were available to facilitate utilization of the raw mass spectrometry data, especially low-abundance metabolites. Here we describe an automated computational framework to annotate ions for possible chemical identity using a multistage clustering algorithm in which metabolic pathway associations are used along with intensity profiles, retention time characteristics, mass defect, and isotope/adduct patterns...
January 17, 2017: Analytical Chemistry
Jeová Nina Rocha
OBJECTIVE: cystometric evaluation of the bladder after autotransplant and isogeneic transplant in female rats. MATERIAL AND METHODS: two groups were constituted: (A) bladder autotransplant with two subgroups: R1 - (control) and R2 - (bladder transplant); (B) isogeneic bladder transplant with three subgroups; T1 - (control); T2-T3, two subgroups observed for 30 and 60 days after transplant, respectively. All animals underwent cystometric evaluation. Afterwards, the bladders were removed for histological study...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Steven Rothenberg
PURPOSE: Thoracoscopic lobectomy for congenital cystic lung disease has become an accepted and in many institutions the preferred technique. However, the technical challenges are many. Previous endoscopic staplers (12 mm) used commonly in adults are too large for use in infants This study evaluates the safety and efficacy of using a 5 mm stapling device to seal and divide major pulmonary structures. METHODS: From July 2014 to March 2016, 26 patients of age 6 weeks to 13 months underwent thoracoscopic lobectomy for CPAM or sequestration...
December 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Stephen S F Yip, John Kim, Thibaud P Coroller, Chintan Parmar, Emmanuel Rios Velazquez, Elizabeth Huynh, Raymond H Mak, Hugo J W L Aerts
PET-based radiomics have been used to noninvasively quantify the metabolic tumor phenotypes; however, little is known about the relationship between these phenotypes and underlying somatic mutations. This study assessed the association and predictive power of (18)F-FDG PET-based radiomic features for somatic mutations in non-small cell lung cancer patients. Methods: Three hundred forty-eight non-small cell lung cancer patients underwent diagnostic (18)F-FDG PET scans and were tested for genetic mutations. Thirteen percent (44/348) and 28% (96/348) of patients were found to harbor epidermal growth factor receptor (EGFR) or Kristen rat sarcoma viral (KRAS) mutations, respectively...
April 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Sophie Liabeuf, Kamel Masmoudi, Lucie-Marie Scailteux, Julien Moragny, Henri Masson, Valérie Brnet-Dufour, Michel Andrejak, Valérie Gras-Champel
Although drug therapy is inherently associated with the risk of adverse drug reactions (ADRs), some of these events are preventable. The estimated proportion of preventable ADRs varies from one study or clinical context to another. Bleeding caused by antithrombotic agents (and particularly vitamin K antagonists, VKAs) constitutes one of the most frequent causes of ADR-related hospitalization.Hence, the objective of the present study was to adapt and validate an ADR preventability score for bleeding due to VKAs and evaluate the preventability of bleeding in 906 consecutive hospitalized, VKA-treated adult patients with a risk of major bleeding (defined as an international normalized ratio ≥5) over a 2-year period...
September 2016: Medicine (Baltimore)
Laila Mahir, Siham Zahi, Karima Belhaj, Fatima Lmidmani, Abdellatif El Fatimi
OBJECTIVE: The isokinetic allows precise and reproducible measurement of muscle strength in the normal state and in various pathological contexts. Its use in neurological diseases is limited, despite its vast scope. To report the profile isokinetic knee during the decisive cauda equina syndrome as a buoyant building program, through 2 comments. OBSERVATIONS: Observation 1: patient aged 58 years, without particular pathological ATCDS, which has a cauda equina syndrome of herniated disc L4/L5 made...
September 2016: Annals of Physical and Rehabilitation Medicine
(no author information available yet)
Of the 26 contributors to Assessing Interventions: Traditional and Innovative Methods, Volume 4, there is only one nursing contributor; the majority of the remainder being medical doctors from the USA. Of the 246 pages, just nine are used by the nurse contributor, who says little that is new about qualitative methods in researching nursing care. The book needs to be read with the primary health-care team in mind.. It is divided into four sections. Section One considers basic issues in assessing interventions in primary care; the second section looks at the application of alternative methodologies - quantitative and qualitative...
March 3, 1993: Nursing Standard
Simon M Bell, Basil Sharrack, John A Snowden
Autologous haematopoietic cell transplantation (AHCT) is an evolving treatment avenue in multiple sclerosis (MS), which may be highly effective in controlling disease activity and improving disability. However, AHCT is associated with intrinsic toxicities and risks compared with conventional therapies. With growing experience in patient selection and treatment delivery, AHCT is increasingly considered an option in patients with aggressive disease that's responding poorly to disease modifying therapy. Areas covered: This article provides an introduction to AHCT and looks at its development as a treatment for MS over the last 20 years...
January 2017: Expert Opinion on Biological Therapy
Xin-Gui Peng, Yingying Bai, Judy R James, Darya P Shlapak, Shenghong Ju
Endothelial progenitor cells (EPCs) play an important role in repairing ischemia tissues. Diffusion tensor imaging (DTI) was applied to detect the architectural organization of skeletal muscle. This study investigated the feasibility and accuracy of using the DTI to evaluate effectiveness of EPCs treatment. Mouse bone marrow-derived EPCs were isolated, cultured, characterized, and transplanted to hindlimb ischemia mice model. DTI was performed on the hindlimb at postischemia time points. The edema regions of diffusion restriction (high signal in diffusion weighted imaging) were decreased in the ischemic muscle of EPCs treated mice after 14 days compared with the controls...
2016: Stem Cells International
Steven A Newman, Roger E Turbin, Mary E Bodach, Luis M Tumialan, Nelson M Oyesiku, Zachary Litvack, Gabriel Zada, Chirag G Patil, Manish K Aghi
BACKGROUND: Nonfunctioning pituitary adenomas (NFPAs) are the most frequent pituitary tumors. Visual symptoms from NFPAs are common and include visual field defects, loss of central vision, and motility problems resulting in diplopia. OBJECTIVE: To create evidence-based guidelines in an attempt to formulate guidance for preoperative ophthalmologic evaluation of NFPA patients. METHODS: An extensive literature search was performed. Only clinical articles describing preoperative ophthalmologic evaluation of adult patients with NFPA were included...
October 2016: Neurosurgery
J M Pardal-Fernandez, S Ezsol-Lendvai, M Rodriguez-Vazquez, J L Agudo-Mena, B Godes-Medrano
INTRODUCTION: Leprosy is an infectious disease caused by the bacteria Mycobacterium leprae. It is particularly prone to affect the skin and the nerve trunks and, in fact, both are compromised in most infected patients. It is transmitted by exposure to those with the disease and sometimes by reactivation. One uncommon possibility is pure neural leprosy, which is characterised by neuropathy, but without skin lesions. We report the case of a patient with pure neural leprosy and review the diagnostic aspects...
September 16, 2016: Revista de Neurologia
Ismail Yağmur, Burak Turna, Ali Tekin, Emir Akıncıoğlu, Bnu Sarsık, İbrahim Ulman
INTRODUCTION: Benign prostatic hyperplasia (BPH) is generally common in men older than 50 years of age but is extremely rare in childhood. In the literature to date, fewer than five cases have been reported under 18 years of age. Owing to the limited number of cases, the etiology and management of BPH in the first two decades is not clear. OBJECTIVE: We herein report a 17-year-old boy who presented with acute urinary retention due to BPH and was treated with endoscopic transurethral resection of the prostate (TUR-P)...
August 2016: Journal of Pediatric Urology
Virginia Harrison, Sarah Mackenzie Ross
Previous research suggests that individuals with a prior history of pesticide poisoning are at increased risk of psychiatric disorder (Freire and Koifman, 2013), but findings regarding the impact of cumulative low-level exposure are inconsistent. The aim of the current study was to investigate whether sheep farmers with a history of low-level exposure to organophosphate pesticides (1) report a higher level of psychological distress on subjective symptom questionnaires, compared to unexposed controls (2) also meet internationally agreed diagnostic criteria for a psychiatric disorder more often than unexposed controls...
November 2016: Environmental Research
Ke Zu, Ge Tao, Julie E Goodman
BACKGROUND: In the 2014 Integrated Risk Information System (IRIS) assessment for Libby amphibole asbestos (LAA), US EPA calculated a reference concentration (RfC) based on the prevalence of pleural plaques in a group of vermiculite workers in Marysville, Ohio. This RfC is based on the assumption that pleural plaques are associated with adverse lung function. In this study, we evaluated the association between pleural plaques and lung function in the Marysville worker cohort to determine whether they are associated with adverse effects or, rather, are more likely a biomarker of cumulative exposure to LAA...
September 2016: Inhalation Toxicology
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