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https://www.readbyqxmd.com/read/29782957/the-role-of-monoamines-in-the-development-of-alzheimer-s-disease-and-neuroprotective-effect-of-a-proline-rich-polypeptide
#1
Konstantin Yenkoyan, Katarine Fereshetyan, Senik Matinyan, Vergine Chavushyan, Michail Aghajanov
INTRODUCTION: We have analyzed the alterations in the brain monoaminergic system using the rat model of AD-like pathology. In addition, we have investigated potential neuroprotective effects of the hypothalamic proline-rich polypeptide (PRP-1). METHODS: Histochemical staining, HPLC, chemiluminescent and bioluminescence assays. RESULTS: The levels of monoamines in the target AD brain structures were found elevated, except serotonin, which was unaffected in both hippocampus and brainstem and decreased in frontal cortex...
May 18, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29780836/defining-platelet-rich-plasma-usage-by-team-physicians-in-elite-athletes
#2
David E Kantrowitz, Ajay S Padaki, Christopher S Ahmad, T Sean Lynch
Background: The indications for the use of platelet-rich plasma (PRP) are vaguely defined despite the frequency of its use as a treatment for athletes. While select studies have advocated for its efficacy, the majority of orthopaedic research conducted on the topic has been equivocal. Purpose: To define the use of PRP in elite athletes by team physicians from professional sports leagues. Study Design: Cross-sectional study. Methods: A survey assessing treatment timing, usage patterns, indications, and complications was generated by fellowship-trained sports medicine orthopaedic surgeons...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29770602/full-title-cultures-of-a-human-synovial-cell-line-to-evaluate-platelet-rich-plasma-and-hyaluronic-acid-effects
#3
E Olivotto, G Merli, E Assirelli, C Cavallo, E Belluzzi, R Ramonda, M Favero, G Filardo, A Roffi, E Kon, B Grigolo
Synovial inflammation plays an important role in osteoarthritis (OA) pathogenesis. Different biological compounds have been tested mainly on chondrocytes, to treat early stages of OA. However, since OA has been recently defined as "an organ" pathology, investigation on synoviocytes is also needed. Therefore the aim of the present study was to validate a human fibroblast-like synoviocytes cell line (K4IM) to test the effects of platelet-rich plasma (PRP) and hyaluronan (HA) on anabolic and catabolic gene expression and on HA secretion from cell cultures...
May 16, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29751170/transesterification-of-para-hydroxybenzoic-acid-esters-parabens-in-the-activated-sludge
#4
Lei Wang, Tianzhen Liu, Hongwen Sun, Qixing Zhou
Hydrolysis is generally considered as the main pathway for the degradation of ester-type pollutants in aquatic environments. In this study, we found that when methanol or ethanol presented as the external carbon in the activated sludge, transesterification is very important for the degradation of para-hydroxybenzoic acid esters (parabens). In the activated sludge solutions with 1% methanol added, contribution of transesterification to the degradation of the propyl substituted paraben (PrP) and ethyl substituted paraben (EtP) accounted for 46% and 83%, respectively, in the early stage of the reaction...
May 1, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29749645/right-ventricular-dyssynchrony-and-its-improvements-after-pulmonary-rehabilitation-in-patients-with-chronic-obstructive-pulmonary-disease
#5
Batur Kanar, Beste Ozben, Elif Yıldırım, İpek Ozmen, Rüya Aydin
PURPOSE: Whether pathologic alterations of right ventricle (RV) in chronic obstructive pulmonary disease (COPD) affect intra- and interventricular dyssynchrony due to changes in mechanical activation of the septum and RV is unclear. The aim of this study was to determine mechanical activation and its changes after pulmonary rehabilitation program (PRP) with speckle tracking echocardiography (STE) in COPD patients. METHODS: After the exclusion of 15 patients due to poor echogenicity and 5 patients not tolerating PRP out of 69 consecutive COPD patients undergoing PRP, the remaining 49 patients and 41 healthy subjects were enrolled...
May 11, 2018: Echocardiography
https://www.readbyqxmd.com/read/29744432/bone-grafts-and-biomaterials-substitutes-for-bone-defect-repair-a-review
#6
REVIEW
Wenhao Wang, Kelvin W K Yeung
Bone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft substitutes. Nevertheless, the integration of allogeneic grafts and synthetic substitutes with host bone was found jeopardized in long-term follow-up studies. Hence, the enhancement of osteointegration of these grafts and substitutes with host bone is considerably important. To address this problem, addition of various growth factors, such as bone morphogenetic proteins (BMPs), parathyroid hormone (PTH) and platelet rich plasma (PRP), into structural allografts and synthetic substitutes have been considered...
December 2017: Bioactive Materials
https://www.readbyqxmd.com/read/29740270/therapeutic-effect-of-platelet-rich-plasma-in-rat-spinal-cord-injuries
#7
Nan-Fu Chen, Chun-Sung Sung, Zhi-Hong Wen, Chun-Hong Chen, Chien-Wei Feng, Han-Chun Hung, San-Nan Yang, Kuan-Hao Tsui, Wu-Fu Chen
Platelet-rich plasma (PRP) is prepared by centrifuging fresh blood in an anticoagulant state, and harvesting the platelet-rich portion or condensing platelets. Studies have consistently demonstrated that PRP concentrates are an abundant source of growth factors, such as platelet-derived growth factor (PDGF), transforming growth factor β (TGF-β), insulin-like growth factor 1 (IGF-1), and epithelial growth factor (EGF). The complex mechanisms underlying spinal cord injury (SCI) diminish intrinsic repair and neuronal regeneration...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29704213/%C3%A9-synuclein-strains-and-seeding-in-parkinson-s-disease-incidental-lewy-body-disease-dementia-with-lewy-bodies-and-multiple-system-atrophy-similarities-and-differences
#8
REVIEW
W Peelaerts, L Bousset, V Baekelandt, R Melki
Several age-related neurodegenerative disorders are characterized by the deposition of aberrantly folded endogenous proteins. These proteins have prion-like propagation and amplification properties but so far appear nontransmissible between individuals. Because of the features they share with the prion protein, PrP, the characteristics of pathogenic protein aggregates in several progressive brain disorders, including different types of Lewy body diseases (LBDs), such as Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB), have been actively investigated...
April 27, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29700554/platelet-rich-plasma-as-an-additional-therapeutic-option-for-infected-wounds-with-multi-drug-resistant-bacteria-in-vitro-antibacterial-activity-study
#9
Rıza Aytaç Çetinkaya, Ercan Yenilmez, Patrizio Petrone, Soner Yılmaz, Bayhan Bektöre, Berksan Şimsek, Tuğba Kula Atik, Mustafa Özyurt, Aytekin Ünlü
PURPOSE: Infected wounds, such as diabetic foot infections, are mostly polymicrobial and microorganisms have high resistance rates to antimicrobials. Infected wounds in diabetic patients have high cost, morbidity, and mortality rates. Based on these facts, there is a need for supportive localized treatment options such as platelet-rich plasma (PRP) implementations. Demonstrating the in vitro antimicrobial effect, our aim was to lead up to clinical trials of localized PRP implementations in infected wounds such as diabetic foot infections...
April 26, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29678307/viability-and-functionality-of-mesenchymal-stromal-cells-loaded-on-collagen-microspheres-and-incorporated-into-plasma-clots-for-orthopaedic-application-effect-of-storage-conditions
#10
Olga Wittig, Dylana Diaz-Solano, José Cardier
BACKGROUND: There is evidence showing that human mesenchymal stromal cells (MSC) seeded on collagen microspheres (CM) and incorporated into platelet rich plasma (PRP) clots induce bone formation. For clinical trials it is very important to establish standardization of storage and shipment conditions to ensure the viability and functionality of cellular products. We investigate the effect of storage temperature and time on the viability and functionality of human MSC seeded on CM and included into PRP clots for using in the further clinical application for bone regeneration...
April 5, 2018: Injury
https://www.readbyqxmd.com/read/29663706/patient-specific-bioinks-for-3d-bioprinting-of-tissue-engineering-scaffolds
#11
Negar Faramarzi, Iman K Yazdi, Mahboubeh Nabavinia, Andrea Gemma, Adele Fanelli, Andrea Caizzone, Leon M Ptaszek, Indranil Sinha, Ali Khademhosseini, Jeremy N Ruskin, Ali Tamayol
Bioprinting has emerged as a promising tool in tissue engineering and regenerative medicine. Various 3D printing strategies have been developed to enable bioprinting of various biopolymers and hydrogels. However, the incorporation of biological factors has not been well explored. As the importance of personalized medicine is becoming more clear, the need for the development of bioinks containing autologous/patient-specific biological factors for tissue engineering applications becomes more evident. Platelet-rich plasma (PRP) is used as a patient-specific source of autologous growth factors that can be easily incorporated to hydrogels and printed into 3D constructs...
April 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29614519/clinical-determinants-of-thrombin-generation-measured-in-presence-and-absence-of-platelets-results-from-the-gutenberg-health-study
#12
Marina Panova-Noeva, Andreas Schulz, Henri M Spronk, Aline Beicht, Dagmar Laubert-Reh, Rene van Oerle, Natalie Arnold, Jürgen H Prochaska, Maria Blettner, Manfred Beutel, Norbert Pfeiffer, Thomas Münzel, Karl J Lackner, Hugo Ten Cate, Philipp S Wild
The tendency of a plasma sample to generate thrombin, a central enzyme in blood coagulation, might be an important indicator of prothrombotic risk linked to cardiovascular disease (CVD), but the presence of platelets may be a critical determinant. Clinical data, laboratory markers and thrombin generation (TG), investigated in both platelet-rich plasma (PRP) and platelet-free plasma (PFP) at 1 pM TF, were available in 407 individuals from the Gutenberg Health Study. Given the well-known effect of anticoagulants on TG, subjects taking anticoagulants ( n  = 15) have been excluded resulting in 392 subjects for further analysis...
April 3, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29605552/automated-structure-and-flow-measurement-a-promising-tool-in-nailfold-capillaroscopy
#13
Michael Berks, Graham Dinsdale, Andrea Murray, Tonia Moore, Joanne Manning, Chris Taylor, Ariane L Herrick
OBJECTIVES: Despite increasing interest in nailfold capillaroscopy, objective measures of capillary structure and blood flow have been little studied. We aimed to test the hypothesis that structural measurements, capillary flow, and a combined measure have the predictive power to separate patients with systemic sclerosis (SSc) from those with primary Raynaud's phenomenon (PRP) and healthy controls (HC). METHODS: 50 patients with SSc, 12 with PRP, and 50 HC were imaged using a novel capillaroscopy system that generates high-quality nailfold images and provides fully-automated measurements of capillary structure and blood flow (capillary density, mean width, maximum width, shape score, derangement and mean flow velocity)...
March 29, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29601383/is-platelet-rich-plasma-injection-effective-for-chronic-achilles-tendinopathy-a-meta-analysis
#14
Yi-Jun Zhang, San-Zhong Xu, Peng-Cheng Gu, Jing-Yu Du, You-Zhi Cai, Chi Zhang, Xiang-Jin Lin
BACKGROUND: Chronic Achilles tendinopathy is common in the general population, and platelet-rich plasma (PRP) is seeing increased use to treat this problem. However, studies disagree as to whether PRP confers a beneficial effect for chronic Achilles tendinopathy, and no one to our knowledge has pooled the available randomized trials in a formal meta-analysis to try to reconcile those differences. QUESTIONS/PURPOSES: In the setting of a systematic review and meta-analysis of randomized controlled trials (RCTs), we asked: Does PRP plus eccentric strength training result in (1) greater improvements in Victorian Institute of Sports Assessment-Achilles (VISA-A) scores; (2) differences in tendon thickness; or (3) differences in color Doppler activity compared with placebo (saline) injections plus eccentric strength training in patients with chronic Achilles tendinopathy? METHODS: A search of peer-reviewed articles was conducted to identify all RCTs using PRP injection with eccentric training for chronic Achilles tendinopathy in the electronic databases of PubMed, Web of Science (SCI-E/SSCI/A&HCI), and EMBASE from January 1981 to August 2017...
March 28, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29601207/nonsurgical-treatments-of-patellar-tendinopathy-multiple-injections-of-platelet-rich-plasma-are-a-suitable-option-a-systematic-review-and-meta-analysis
#15
Luca Andriolo, Sante Alessandro Altamura, Davide Reale, Christian Candrian, Stefano Zaffagnini, Giuseppe Filardo
BACKGROUND: Patellar tendinopathy is a condition characterized by anterior knee activity-related pain. It has a high incidence among athletes engaged in jumping sports and may become a chronic condition. Nonoperative management is the first choice in these patients, and several nonsurgical treatment options have been proposed. Nonetheless, clear indications on the most effective approach to address patellar tendinopathy are still lacking. PURPOSE: To analyze the evidence on nonoperative options to treat chronic patellar tendinopathy through a systematic review of the literature and to perform a meta-analysis to identify the most effective nonsurgical option...
March 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29580990/copper-induces-structural-changes-in-n-terminus-of-human-prion-protein
#16
Bo Lu, Lili Zhao, Kefeng Qin
Copper ions reportedly bind to the cellular prion (PrPC ) and induce PrP proteinase K (PK) resistant from (PrPres ). PrPC also plays a role in response to oxidative stress. By using purified human PrP23-98 containing octarepeats, we have found that Cu(II) induces PrPres determined by Western blots and atomic force microscopy, and structural changes detected by hydrogen/deuterium exchange in the PrP N-terminus. Therefore, we have provided the evidence that copper ions play an important role in the change of N-terminus of human prion protein...
March 23, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29579157/cellular-prion-protein-is-involved-in-decidualization-of-mouse-uterus
#17
Nai-Zheng Ding, Xing-Ming Wang, Xiang-Wen Jiao, Ran Li, Chao Zeng, Shan-Ni Li, Hong-Shan Guo, Ze-You Wang, Zhu Huang, Cheng-Qiang He
Prion protein (PrP) is encoded by a single copy gene Prnp in many cell and tissue types. PrP is very famous for its infectious conformers (PrPSC) resulting in transmissible spongiform encephalopathies (TSEs). At present, physiological functions of its cellular isoform (PrPC) remain ambiguous. Although PrPC expression has been found in uterus, whether it functions in maternal-fetal dialogue during early pregnant is unknown. In this study, we examined PrPC mRNA and protein in the uterus of peri-implantation mice, and found that they were expressed with a spatiotemporal dynamic pattern...
March 20, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29554700/procoagulant-effects-of-low-level-platelet-activation-and-its-inhibition-by-colchicine
#18
Caroline J Reddel, Gabrielle J Pennings, Jennifer L Curnow, Vivien M Chen, Leonard Kritharides
Platelets play an important role in diseases such as cardiovascular disease and cancer, especially through their release of extracellular vesicles (EVs) and role in thrombosis. The effects of the anti-inflammatory drug colchicine on platelets are not well understood. We investigated the effect of colchicine on the release of pro-coagulant EVs from platelets under low-level activation. Citrated platelet-rich plasma (PRP) from healthy donors was incubated with 2 mM colchicine or vehicle at 37°C for 30 minutes with gentle rotation...
April 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29523205/pathologic-and-biochemical-characterization-of-prp-sc-from-elk-with-prnp-polymorphisms-at-codon-132-after-experimental-infection-with-the-chronic-wasting-disease-agent
#19
S Jo Moore, Catherine E Vrentas, Soyoun Hwang, M Heather West Greenlee, Eric M Nicholson, Justin J Greenlee
BACKGROUND: The Rocky Mountain elk (Cervus elaphus nelsoni) prion protein gene (PRNP) is polymorphic at codon 132, with leucine (L132) and methionine (M132) allelic variants present in the population. In elk experimentally inoculated with the chronic wasting disease (CWD) agent, different incubation periods are associated with PRNP genotype: LL132 elk survive the longest, LM132 elk are intermediate, and MM132 elk the shortest. The purpose of this study was to investigate potential mechanisms underlying variations in incubation period in elk of different prion protein genotypes...
March 9, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29494865/autologous-neural-progenitor-cell-transplantation-into-newborn-mice-modeling-for-e200k-genetic-prion-disease-delays-disease-progression
#20
Kati Frid, Orli Binyamin, Nina Fainstein, Guy Keller, Tamir Ben-Hur, Ruth Gabizon
TgMHu2ME199K mice, a transgenic line mimicking genetic prion disease, are born healthy and gradually deteriorate to a terminal neurological condition concomitant with the accumulation of disease-related PrP. To investigate whether transplantation of neural progenitor cells (NPCs) to these mice can delay disease aggravation, we first tested the properties of mutant PrP in homogenates and enriched NPCs from TgMHu2ME199K embryos, as compared to PrP in sick TgMHu2ME199K brains. Next, we tested the clinical effect of NPCs transplantation into newborn TgMHu2ME199K mice...
May 2018: Neurobiology of Aging
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