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https://www.readbyqxmd.com/read/27900155/normal-platelet-function-in-platelet-concentrates-requires-non-platelet-cells-a-comparative-in-vitro-evaluation-of-leucocyte-rich-type-1a-and-leucocyte-poor-type-3b-platelet-concentrates
#1
William R Parrish, Breana Roides, Julia Hwang, Michael Mafilios, Brooks Story, Samir Bhattacharyya
BACKGROUND: Therapeutic success of platelet-rich plasma (PRP) may vary based on the composition and preparation method. The objective of this study was to evaluate the cellular components of platelet concentrates produced by a leucocyte-rich (LR-PRP) and a leucocyte-poor PRP systems (LP-PRP). METHODS: Parameters evaluated included platelet recovery, platelet concentration, red blood cell (RBC) and white blood cell (WBC) composition, platelet growth factor release and stimulation of human tendon cell proliferation in vitro...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27900099/effect-of-cytostatic-proline-rich-polypeptide-1-on-tumor-suppressors-of-inflammation-pathway-signaling-in-chondrosarcoma
#2
Karina Galoian, Shihua Luo, Amir Qureshi, Parthik Patel, Rachel Price, Ashlyn S Morse, Gor Chailyan, Silva Abrahamyan, H T Temple
Cytokines produced in the tumour microenvironment exert an important role in cancer pathogenesis and in the inhibition of disease progression. Cancer of the cartilage is termed metastatic chondrosarcoma; however, the signaling events resulting in mesenchymal cell transformation to sarcoma have yet to be fully elucidated. The present study aimed to characterize the cytokine expression profile in the human JJ012 chondrosarcoma cell line, as well as the effect of cytostatic proline-rich polypeptide-1 (PRP-1). Western blot experiments demonstrated that the levels of suppressor of cytokine signaling 3 (SOCS3) were upregulated in chondrocytes compared with chondrosarcoma cells...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27896708/asymmetric-interference-in-concurrent-time-to-contact-estimation-cousin-or-twin-of-the-psychological-refractory-period-effect
#3
Robin Baurès, Patricia R DeLucia, Megan Olson, Daniel Oberfeld
In a reaction time (RT) task requiring fast responses to two stimuli presented close in time, human observers show a delayed RT to the second stimulus. This phenomenon has been attributed to a psychological refractory period (PRP). A similar asymmetric interference is found when performing multiple concurrent visual time-to-contact (TTC) estimations for moving objects, despite important differences between the tasks. In the present study, we studied the properties of the asymmetric interference found in the TTC task and compared them to the classical PRP effect...
November 28, 2016: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/27880767/distribution-of-misfolded-prion-protein-seeding-activity-alone-does-not-predict-regions-of-neurodegeneration
#4
James Alibhai, Richard A Blanco, Marcelo A Barria, Pedro Piccardo, Byron Caughey, V Hugh Perry, Tom C Freeman, Jean C Manson
Protein misfolding is common across many neurodegenerative diseases, with misfolded proteins acting as seeds for "prion-like" conversion of normally folded protein to abnormal conformations. A central hypothesis is that misfolded protein accumulation, spread, and distribution are restricted to specific neuronal populations of the central nervous system and thus predict regions of neurodegeneration. We examined this hypothesis using a highly sensitive assay system for detection of misfolded protein seeds in a murine model of prion disease...
November 2016: PLoS Biology
https://www.readbyqxmd.com/read/27849581/amyloid-fibrils-from-the-n-terminal-prion-protein-fragment-are-infectious
#5
Jin-Kyu Choi, Ignazio Cali, Krystyna Surewicz, Qingzhong Kong, Pierluigi Gambetti, Witold K Surewicz
Recombinant C-terminally truncated prion protein PrP23-144 (which corresponds to the Y145Stop PrP variant associated with a Gerstmann-Sträussler-Scheinker-like prion disease) spontaneously forms amyloid fibrils with a parallel in-register β-sheet architecture and β-sheet core mapping to residues ∼112-139. Here we report that mice (both tga20 and wild type) inoculated with a murine (moPrP23-144) version of these fibrils develop clinical prion disease with a 100% attack rate. Remarkably, even though fibrils in the inoculum lack the entire C-terminal domain of PrP, brains of clinically sick mice accumulate longer proteinase K-resistant (PrP(res)) fragments of ∼17-32 kDa, similar to those observed in classical scrapie strains...
November 29, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27847358/prp-knockout-cells-expressing-transmembrane-prp-resist-prion-infection
#6
Karen E Marshall, Andrew Hughson, Sarah Vascellari, Suzette A Priola, Akikazu Sakudo, Takashi Onodera, Gerald S Baron
: Glycosylphosphatidylinositol (GPI) anchoring of the prion protein (PrP(C)) influences PrP(C) misfolding into the disease-associated isoform, PrP(res), as well as prion propagation and infectivity. GPI proteins are found in cholesterol and sphingolipid-rich membrane regions called rafts. Exchanging the GPI anchor for a non-raft transmembrane sequence redirects PrP(C) away from rafts. Previous studies showed that non-raft transmembrane PrP(C) variants resist conversion to PrP(res) when transfected into scrapie-infected N2a neuroblastoma cells, likely due to segregation of transmembrane PrP(C) and GPI-anchored PrP(res) in distinct membrane environments...
November 9, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27845852/platelet-rich-plasma-a-source-of-autologous-growth-factors-and-biomimetic-scaffold-for-peripheral-nerve-regeneration
#7
Mikel Sánchez, Eduardo Anitua, Diego Delgado, Peio Sanchez, Roberto Prado, Gorka Orive, Sabino Padilla
In mammals, axons of injured peripheral nerves (PNI) can and do regenerate, but often the functional recovery is incomplete or suboptimal. In recent years, in vivo tissue engineering approaches through molecular intervention and scaffolding are offering promising outcomes. Evidence is accumulating in both preclinical and clinical settings indicating that platelet rich plasma (PRP) and fibrin scaffolds obtained from this technology hold an important adjuvant therapeutic potential. Areas covered: This review addresses current molecular and cellular data in intrinsic nerve repair processes and describes different strategies to harness and enhance these processes by using biochemical and biomechanical cues...
November 15, 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/27825366/l-bse-experimentally-transmitted-to-sheep-presents-as-a-unique-disease-phenotype
#8
Marion M Simmons, Melanie J Chaplin, Timm Konold, Cristina Casalone, Katy E Beck, Leigh Thorne, Sharon Everitt, Tobias Floyd, Derek Clifford, John Spiropoulos
Apart from prion protein genotype, the factors determining the host range and susceptiblity for specific transmissible spongiform encephalopathy agents remain unclear. It is known that bovine atypical L-BSE can transmit to a range of species including primates and humanised transgenic mice. It is important, therefore, that there is as broad an understanding as possible of how such isolates might present in food animal species and how robust they are on inter- and intra-species transmission to inform surveillance sytems and risk assessments...
November 8, 2016: Veterinary Research
https://www.readbyqxmd.com/read/27825020/are-participants-reports-of-their-own-reaction-times-reliable-re-examining-introspective-limitations-in-active-and-passive-dual-task-paradigms
#9
Donna Bryce, Daniel Bratzke
There is a known introspective limitation in the Psychological Refractory Period (PRP) paradigm - people underestimate the dual-task costs on their second reaction time. The prevailing explanation for this is that conscious awareness of the second stimulus is delayed in time until the first task has been centrally processed. Here, we examined this effect in more detail, by comparing reaction time estimates after processing a PRP task, and after passively experiencing 'replays' of PRP trials. Even when participants had no dual-task processing demands, they did not accurately report the reaction time intervals using a visual analogue scale (the original reporting method of most introspective PRP experiments), but they did when placing markers that represent each event on a timeline...
November 5, 2016: Acta Psychologica
https://www.readbyqxmd.com/read/27815972/toll-like-receptor-9-expression-and-activation-in-acute-coronary-syndrome-patients-on-dual-anti-platelet-therapy
#10
Kathryn E Hally, Anne C La Flamme, Peter D Larsen, Scott A Harding
INTRODUCTION: The Toll-like receptor 9 (TLR9) pathway can activate platelets but its role in acute coronary syndromes (ACS) is unknown. This study examined TLR9 expression and platelet activation in response to ODN2006, a TLR9 agonist, in healthy subjects and in ACS subjects treated with dual anti-platelet therapy (DAPT). MATERIALS AND METHODS: TLR9 expression was examined in both resting and thrombin receptor activator peptide (TRAP)-activated platelets (1 and 10μM) from healthy and ACS subjects by flow cytometry...
October 29, 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27807855/atypical-scrapie-in-australia
#11
R W Cook, J Bingham, A S Besier, C L Bayley, M Hawes, P L Shearer, M Yamada, J Bergfeld, D T Williams, D J Middleton
BACKGROUND: Since its initial detection in Norway in 1998, atypical scrapie ('atypical/Nor98 scrapie') has been reported in sheep in the majority of European countries (including in regions free of classical scrapie) and in the Falkland Islands, the USA, Canada, New Zealand and Australia. CASE SERIES: The diagnosis in Australia of atypical scrapie in four Merino and one Merino-cross sheep showing clinical signs of neurological disease was based on the detection of grey matter neuropil vacuolation (spongiform change) in the brain (particularly in the molecular layer of the cerebellar cortex) and associated abnormal prion protein (PrP(Sc) ) deposition in both grey and white matter...
November 3, 2016: Australian Veterinary Journal
https://www.readbyqxmd.com/read/27791311/platelets-rich-plasma-versus-minoxidil-5-in-treatment-of-alopecia-areata-a-trichoscopic-evaluation
#12
Moustafa A El Taieb, Hassan Ibrahim, Essam A Nada, Mai Seif Al-Din
Alopecia areata is a common cause of nonscarring alopecia that occurs in a patchy, confluent, or diffuse pattern. Dermoscopy is a noninvasive technique for the clinical diagnosis of many skin diseases. Topical minoxidil solution 5% and platelet rich plasma are important modalities used in treatment of alopecia areata. We aimed to evaluate the efficacy of PRP versus topical minoxidil 5% in the treatment of AA by clinical evaluation and trichoscopic examination. Ninety patients were allocated into three groups; the first was treated with topical minoxidil 5% solution, the second with platelets rich plasma injections, and the third with placebo...
October 28, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27782270/enhanced-bone-morphogenic-property-of-parylene-c
#13
Ya-Ting Tsai, Chao-Wei Huang, Hui-Yu Liu, Mei-Ching Huang, Ting-Pi Sun, Wen-Chien Chen, Chih-Yu Wu, Shih-Torng Ding, Hsien-Yeh Chen
The ability to induce osteointegration was introduced to a parylene-C surface via the simple and intuitive process of protein adsorption mediated by hydrophobic interactions. In this way, bone morphogenetic protein (BMP)-2, fibronectin, and platelet-rich plasma (PRP) could be immobilized on parylene-C surfaces. This approach alleviates concerns related to the use of potentially harmful substances in parylene-C modification processes. The adsorbed protein molecules were quantitatively characterized with respect to adsorption efficacy and binding affinity, and the important biological activities of the proteins were also examined using both early and late markers of osteogenetic activity, including alkaline phosphatase expression, calcium mineralization and marker gene expression...
October 26, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27778530/gpvi-modulation-during-platelet-activation-and-storage-its-expression-levels-and-ectodomain-shedding-compared-to-markers-of-platelet-storage-lesion
#14
Ehteramolsadat Hosseini, Mehran Ghasemzadeh, Fatemeh Nassaji, Zeynab Pirmohammad Jamaat
Platelet storage is associated with deleterious changes leading to the loss of platelet reactivity and response. During storage, platelets experience increased expression and shedding of P-selectin and CD40L as specific markers of platelet activation, whereas GPIbα decreases due to ectodomain shedding. As an important adhesive receptor, GPVI contributes significantly to thrombus formation while its expression and shedding levels during storage of platelet products have not been well characterized yet. This study investigated the modulation of GPVI during platelet storage...
October 25, 2016: Platelets
https://www.readbyqxmd.com/read/27761085/outcome-of-intra-operative-injected-platelet-rich-plasma-therapy-during-follicular-unit-extraction-hair-transplant-a-prospective-randomised-study-in-forty-patients
#15
Suruchi Garg
CONTEXT: Platelet-rich plasma (PRP) therapy is finding importance in aesthetic medicine. AIM: The objective of this study was to study efficacy of PRP therapy in follicular unit extraction (FUE) hair transplant. MATERIALS AND METHODS: It is a single-blind, prospective randomised study on 40 FUE hair transplant subjects, allocated in two groups (PRP and non-PRP) alternately. PRP was injected intra-operatively immediately after creating slits over the recipient area in PRP group; and normal saline in non-PRP group...
July 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/27729755/incidence-and-clinical-features-of-neovascularization-of-the-iris-following-acute-central-retinal-artery-occlusion
#16
Young Ho Jung, Seong Joon Ahn, Jeong-Ho Hong, Kyu Hyung Park, Moon-Ku Han, Cheolkyu Jung, Se Joon Woo
PURPOSE: To investigate the incidence of neovascularization of the iris (NVI) and clinical features of patients with NVI following acute central retinal artery occlusion (CRAO). METHODS: A retrospective review of 214 consecutive CRAO patients who visited one tertiary hospital between January 2009 and January 2015 was conducted. In total, 110 patients were eligible for this study after excluding patients with arteritic CRAO, a lack of follow-up, iatrogenic CRAO secondary to cosmetic filler injection, or NVI detected before CRAO attack...
October 2016: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/27707644/effect-of-acoustic-parameters-on-the-cavitation-behavior-of-sonovue-microbubbles-induced-by-pulsed-ultrasound
#17
Yutong Lin, Lizhou Lin, Mouwen Cheng, Lifang Jin, Lianfang Du, Tao Han, Lin Xu, Alfred C H Yu, Peng Qin
SonoVue microbubbles could serve as artificial nuclei for ultrasound-triggered stable and inertial cavitation, resulting in beneficial biological effects for future therapeutic applications. To optimize and control the use of the cavitation of SonoVue bubbles in therapy while ensuring safety, it is important to comprehensively understand the relationship between the acoustic parameters and the cavitation behavior of the SonoVue bubbles. An agarose-gel tissue phantom was fabricated to hold the SonoVue bubble suspension...
March 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27676677/timing-of-platelet-rich-plasma-injections-during-antithrombotic-therapy
#18
Ryan Ravi Ramsook, Houman Danesh
The use of platelet rich plasma (PRP) spans across many fields owing to its role in healing and as a natural alternative to surgery. PRP continues to grow however much of the literature is anecdotal or case report based and there is a lack of controlled trials to evaluate standards for PRP. The International Cellular Medical Society (ICMS) has developed guidelines to help with the safe advancement of PRP; however there remains a gap in literature concerning the timing of PRP injections in patients who are on antithrombotic therapy...
September 2016: Pain Physician
https://www.readbyqxmd.com/read/27649962/analysis-of-photobiomodulation-associated-or-not-with-platelet-rich-plasma-on-repair-of-muscle-tissue-by-raman-spectroscopy
#19
Guilherme Akio Tamura Ozaki, Regina Celi Trindade Camargo, Tatiana Emy Koike, Thiago Alves Garcia, Robson Chacon Castoldi, João Domingos Augusto Dos Santos Pereira, Carlos José Leopoldo Constantino, José Carlos Silva Camargo Filho
Treatment of muscle injuries usually results in the interruption of sports practice; thus, studies aimed at accelerating the return to activity, with proper tissue repair, are important. Therefore, this study aimed to evaluate the effects of photobiomodulation (PBM), associated or not with platelet-rich plasma (PRP), on the treatment of muscle injury. Thirty-five animals were used and divided into five groups (n = 7): control (C), control lesion (CL), lesion treated with low-level laser therapy (LLLT) (LLt), lesion treated with PRP (LP), and lesion treated with both techniques, LLLT and PRP (LLtP)...
December 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27649856/uncontrolled-sfk-mediated-protein-trafficking-in-prion-and-alzheimer-s-disease
#20
Edward Málaga-Trillo, Katharina Ochs
Prions and Amyloid beta (Aβ) peptides induce synaptic damage via complex mechanisms that include the pathological alteration of intracellular signaling cascades. The host-encoded cellular prion protein (PrP(C)) acts as a high-affinity cell surface receptor for both toxic species and it can modulate the endocytic trafficking of the N-methyl D-aspartate (NMDA) receptor and E-cadherin adhesive complexes via Src family kinases (SFKs). Interestingly, SFK-mediated control of endocytosis is a widespread mechanism used to regulate the activity of important transmembrane proteins, including neuroreceptors for major excitatory and inhibitory neurotransmitters...
September 2, 2016: Prion
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