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https://www.readbyqxmd.com/read/29786779/dnmt3a-controls-mir-200b-in-cardiac-fibroblast-autophagy-and-cardiac-fibrosis
#1
Xu-Dong Zhao, Run-He Qin, Jing-Jing Yang, Sheng-Song Xu, Hui Tao, Xuan-Sheng Ding, Kai-Hu Shi
AIM AND OBJECTIVE: Regulation of microRNA gene expression by DNA methylation may represent a key mechanism to drive cardiac fibrosis progression. Cardiac fibroblast autophagy is the primary source of cardiac fibrosis, but the mechanisms underlying this process are incompletely understood. Here we found that DNMT3A suppression of the microRNA-200b (miR-200b) through pathway leads to cardiac fibroblast autophagy in cardiac fibrosis. METHODS: To understand the impact of DNMT3A on miR-200b at cardiac fibrosis, the rat cardiac fibrosis model was established via the abdominal aortic coarctation...
May 21, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29779159/an-etiological-approach-to-sexual-offender-assessment-case-formulation-incorporating-risk-assessment-cafira
#2
REVIEW
Leam A Craig, Martin Rettenberger
PURPOSE OF REVIEW: Case formulations (CF) have been the cornerstone of effective practice in clinical psychology since the 1950s and now form one of the core competencies in clinical and forensic assessment. The use of CFs within forensic settings is becoming more relevant when working with offenders who have experienced significant trauma, suffered from personality disorder, and have displayed sexually abusive behavior. Furthermore, most North American and European jurisdictions insist that expert witnesses adopt an idiosyncratic approach to risk assessment and consider the characteristics of the individual as part of a wider formulation of the problem behavior...
May 19, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29778473/characterization-of-best-linear-unbiased-estimates-generated-from-national-genetic-evaluations-of-reproductive-performance-survival-and-milk-yield-in-dairy-cows
#3
F L Dunne, M M Kelleher, S W Walsh, D P Berry
Genetic evaluations decompose an observed phenotype into its genetic and nongenetic components; the former are termed BLUP with the solutions for the systematic environmental effects in the statistical model termed best linear unbiased estimates (BLUE). Geneticists predominantly focus on the BLUP and rarely consider the BLUE. The objective of this study, however, was to define and quantify the association between 8 herd-level characteristics and BLUE for 6 traits in dairy herds, namely (1) age at first calving, (2) calving to first service interval (CFS), (3) number of services, (4) calving interval (CIV), (5) survival, and (6) milk yield...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29775892/microrna-135a-inhibits-cardiac-fibrosis-induced-by-isoproterenol-via-trpm7-channel
#4
Yan Wu, Yonghui Liu, Yitong Pan, Chunxiao Lu, Haonan Xu, Xiaozhi Wang, Tingting Liu, Kai Feng, Yiqun Tang
BACKGROUND: Cardiac fibrosis is a crucial factor of heart failure. It has been reported that several microRNAs (miRNAs, miRs) were involved in cardiac fibrosis, however, the role and possible regulatory mechanism of microRNA-135a (miR-135a) in cardiac fibrosis have not been investigated. Here, we explored the regulation mechanism of miR-135a on cardiac fibrosis. METHODS AND RESULTS: In vitro, cardiac fibroblasts (CFs) from neonatal rats were treated by isoproterenol (ISO) at the final concentration of 10 μM for 24 h and miR-135a expression was decreased obviously...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29775120/successful-improvement-of-pain-symptomatology-in-a-suspected-case-of-cramp-fasciculation-syndrome-via-interventional-pain-treatment
#5
Anita Gupta, Lucas First, Celeste A Swain
Peripheral nerve hyperexcitability (PNH) syndromes are a rare set of neuromuscular disorders that include cramp-fasciculation syndrome (CFS) and Isaacs syndrome (IS). Successful treatment of these diseases has been achieved with antiepileptic medications; however, chronic pain symptoms can persist. We provide a case report of a 25-year-old female who has suffered from painful severe muscle spasms and fasciculations since childhood. With CFS as our working diagnosis, a treatment regimen using interventional pain techniques, including sympathetic chain blocks, ketamine infusions, and trigger point injections, resulted in a significant decrease in the patient's chronic pain symptoms...
May 18, 2018: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/29774388/withholding-or-withdrawing-of-life-sustaining-therapy-in-older-adults-%C3%A2-80-years-admitted-to-the-intensive-care-unit
#6
Bertrand Guidet, Hans Flaatten, Ariane Boumendil, Alessandro Morandi, Finn H Andersen, Antonio Artigas, Guido Bertolini, Maurizio Cecconi, Steffen Christensen, Loredana Faraldi, Jesper Fjølner, Christian Jung, Brian Marsh, Rui Moreno, Sandra Oeyen, Christina Agwald Öhman, Bernardo Bollen Pinto, Ivo W Soliman, Wojciech Szczeklik, Andreas Valentin, Ximena Watson, Tilemachos Zafeiridis, Dylan W De Lange
PURPOSE: To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU. METHODS: This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up. RESULTS: LST limitation was identified in 1356/5021 (27.2%) of patients: 15% had a withholding decision and 12.2% a withdrawal decision (including those with a previous withholding decision)...
May 17, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29773431/preoperative-frailty-assessment-predicts-loss-of-independence-after-vascular-surgery
#7
Graham W Donald, Amir A Ghaffarian, Farid Isaac, Larry W Kraiss, Claire L Griffin, Brigitte K Smith, Mark R Sarfati, Julie L Beckstrom, Benjamin S Brooke
OBJECTIVE: Frailty, a clinical syndrome associated with loss of metabolic reserves, is prevalent among patients who present to vascular surgery clinics for evaluation. The Clinical Frailty Scale (CFS) is a rapid assessment method shown to be highly specific for identifying frail patients. In this study, we sought to evaluate whether the preoperative CFS score could be used to predict loss of independence after major vascular procedures. METHODS: We identified all patients living independently at home who were prospectively assessed using the CFS before undergoing an elective major vascular surgery procedure (admitted for >24 hours) at an academic medical center between December 2015 and December 2017...
May 14, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29773400/synthesis-of-novel-cellulose-based-antibacterial-composites-of-ag-nanoparticles-metal-organic-frameworks-carboxymethylated-fibers
#8
Chao Duan, Jingru Meng, Xinqi Wang, Xin Meng, Xiaole Sun, Yongjian Xu, Wei Zhao, Yonghao Ni
A novel cellulose-based antibacterial material, namely silver nanoparticles@ metal-organic frameworks@ carboxymethylated fibers composites (Ag NPs@ HKUST-1@ CFs), was synthesized. The results showed that the metal-organic frameworks (HKUST-1) were uniformly anchored on the fiber's surfaces by virtue of complexation between copper ions in HKUST-1 and carboxyl groups on the carboxymethylated fibers (CFs). The silver nanoparticles (Ag NPs) were immobilized and well-dispersed into the pores and/or onto the surfaces of HKUST-1 via in situ microwave reduction, resulting in the formation of novel Ag NPs@ HKUST-1@ CFs composites...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773208/childhood-sleep-and-adolescent-chronic-fatigue-syndrome-cfs-me-evidence-of-associations-in-a-uk-birth-cohort
#9
Simon M Collin, Tom Norris, Paul Gringras, Peter S Blair, Kate Tilling, Esther Crawley
OBJECTIVE/BACKGROUND: Sleep abnormalities are characteristic of chronic fatigue syndrome (CFS, also known as 'ME'), however it is unknown whether sleep might be a causal risk factor for CFS/ME. PATIENTS/METHODS: We analysed data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. We describe sleep patterns of children aged 6 months to 11 years, who were subsequently classified as having (or not having) 'chronic disabling fatigue' (CDF, a proxy for CFS/ME) between the ages 13 and 18 years, and we investigated the associations of sleep duration at age nine years with CDF at age 13 years, as well as sleep duration at age 11 years with CDF at age 16 years...
June 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29772739/dutch-health-council-advisory-report-on-myalgic-encephalomyelitis-and-chronic-fatigue-syndrome-taking-the-wrong-turn
#10
Frank Twisk
Recently, the Dutch Health Council published their advisory report on Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) which is meant to determine the medical policy with regard to ME in the Netherlands. The Health Council briefly discusses several diagnostic criteria and proposes to use new diagnostic criteria for "ME/CFS" in research and clinical practice in the future. The advisory report then summarizes organic abnormalities observed in the last decades and concludes that "ME/CFS" is a "serious, chronic, multisystem disease"...
May 16, 2018: Diagnostics
https://www.readbyqxmd.com/read/29772554/antibodies-against-gpcr
#11
Carlotto Meyer, Harald Heidecke
G-protein-coupled receptors (GPCRs) are the largest family of receptors in humans. GPCRs are seven-transmembrane receptors that are activated by the binding of a ligand to the extracellular domain. In addition to the endogenous ligands, auto-antibodies (aab) can also bind to the GPCRs. They can activate different and specific cellular pathways which contribute to various diseases. In this review, the authors summarize the knowledge about antibodies targeting GPCRs and their effects and relevance in the pathogenesis of various diseases and their use in clinical diagnostics...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29770505/poor-self-reported-sleep-quality-and-health-related-quality-of-life-in-patients-with-chronic-fatigue-syndrome-myalgic-encephalomyelitis
#12
Jesús Castro-Marrero, Maria C Zaragozá, Sergio González-Garcia, Luisa Aliste, Naia Sáez-Francàs, Odile Romero, Alex Ferré, Tomás Fernández de Sevilla, José Alegre
Non-restorative sleep is a hallmark symptom of chronic fatigue syndrome/myalgic encephalomyelitis. However, little is known about self-reported sleep disturbances in these subjects. This study aimed to assess the self-reported sleep quality and its impact on quality of life in a Spanish community-based chronic fatigue syndrome/myalgic encephalomyelitis cohort. A prospective cross-sectional cohort study was conducted in 1,455 Spanish chronic fatigue syndrome/myalgic encephalomyelitis patients. Sleep quality, fatigue, pain, functional capacity impairment, psychopathological status, anxiety/depression and health-related quality of life were assessed using validated subjective measures...
May 16, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29768845/composited-bioi-nanoplatelets-on-carbon-fibers-towards-enhanced-photocatalysis
#13
Gang Wang, Junpeng Wang, Ping Yang
BiOI nanoplatelets were successfully grown on carbon fibers (CFs) surface, which had been activated in acid and alkaline solution (CFs-AC and CFs-AL). The BiOI microspheres composed of nanoplatelets were distributed relatively equally on CFs surface after acidizing while the CFs treatment by alkaline solution the BiOI nanoplatelets cannot combined tightly with CFs. The as-prepared BiOI/CFs was characterized by X-ray diffraction, scanning electron microscopy and UV-vis diffuse reflectance spectroscopy. The possible mechanism of BiOI/CFs formation was attributed to the electrostatic adsorption in reaction process...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29766240/pulmonary-thermal-ablation-enables-long-chemotherapy-free-survival-in-metastatic-colorectal-cancer-patients
#14
Mariane Fonck, Jean-Thomas Perez, Vittorio Catena, Yves Becouarn, Laurent Cany, Eric Brudieux, Laure Vayre, Patrick Texereau, Valérie Le Brun-Ly, Véronique Verger, Véronique Brouste, Dominique Bechade, Xavier Buy, Jean Palussière
BACKGROUND: Chemotherapy (ct) is the preferred treatment option in metastatic colorectal cancer (mCRC). The objective of the study was to determine the overall survival (OS), disease-free survival (DFS) and ct-free survival (CFS) of pulmonary thermal ablation (TA) and its place in the treatment of mCRC. PATIENTS AND METHODS: All consecutive patients treated (over 11 years) with percutaneous TA for lung metastasis of colorectal origin were reviewed. All sequences of treatments were considered...
May 15, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29763694/corneal-fluorescein-staining-and-ocular-symptoms-but-not-schirmer-test-are-useful-as-indicators-of-response-to-treatment-in-chronic-ocular-gvhd
#15
Francisco Amparo, Hasanain Shikari, Ujwala Saboo, Reza Dana
PURPOSE: To evaluate long-term ocular surface clinical signs and symptoms response to therapy in patients with chronic ocular GVHD. METHODS: Retrospective review and data modeling. We reviewed the records of post-bone marrow transplantation patients who were newly diagnosed with ocular GVHD and initiated therapy, and analyzed changes in symptoms (Ocular Surface Disease Index [OSDI]; Symptom Assessment in Dry Eye [SANDE]) and signs (corneal fluorescein staining [CFS]; Schirmer test)...
May 12, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29763616/influence-of-continuous-flash-suppression-mask-frequency-on-stimulus-visibility
#16
Minye Zhan, Tahnée Engelen, Beatrice de Gelder
The continuous flash suppression (CFS) paradigm is increasingly used in consciousness research, but its mechanisms are still not fully understood. To better understand its temporal properties, we presented the CFS masks at 9 frequencies, and examined their influence on stimuli visibility, while taking into account the inter-individual variability and the change of CFS suppression as the experiment progressed. The frequencies consisted of fundamental frequencies of 3, 4 and 5Hz, and their 2nd and 3rd harmonics, which included the 10Hz frequency typically used in most of the CFS studies...
May 12, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29763415/efficacy-safety-and-cost-of-therapy-of-the-traditional-chinese-medicine-catalpol-in-patients-following-surgical-resection-for-locally-advanced-colon-cancer
#17
Baogang Fei, Wei Dai, Shouhe Zhao
BACKGROUND The aim of this study was to evaluate the efficacy, safety, and cost of treatment of the traditional Chinese herbal medicine, catalpol, in patients following surgical resection for locally advanced colon cancer. MATERIAL AND METHODS The 345 patients who had undergone surgical resection for locally advanced colon adenocarcinoma, were divided into three groups: a placebo-treated group (n=115); patients treated with an intraperitoneal injection of 10 mg/kg catalpol twice a day for 12 weeks (treatment group) (n=115); patients treated with 5 mg/kg intravenous bevacizumab twice a week for 12 weeks (control group) (n=115)...
May 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29760746/microrna-495-inhibits-the-high-glucose-induced-inflammation-differentiation-and-extracellular-matrix-accumulation-of-cardiac-fibroblasts-through-downregulation-of-nod1
#18
Xiaowei Wang, Haiying Jin, Shifeng Jiang, Yanlan Xu
Background: MicroRNAs (miRNAs) have physiological and pathophysiological functions that are involved in the regulation of cardiac fibrosis. This study aimed to investigate the effects of miR-495 on high glucose-induced cardiac fibrosis in human cardiac fibroblasts (CFs) and to establish the mechanism underlying these effects. Methods: Human CFs were transfected with an miR-495 inhibitor or mimic and incubated with high glucose. The levels of NOD1 and miR-495 were then determined via quantitative RT-PCR...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29760651/human-dna-helicase-b-as-a-candidate-for-unwinding-secondary-cgg-repeat-structures-at-the-fragile-x-mental-retardation-gene
#19
Gulfem D Guler, Zev Rosenwaks, Jeannine Gerhardt
The fragile X syndrome (FXS) is caused by a CGG repeat expansion at the fragile X mental retardation ( FMR1 ) gene. FMR1 alleles with more than 200 CGG repeats bear chromosomal fragility when cells experience folate deficiency. CGG repeats were reported to be able to form secondary structures, such as hairpins, in vitro . When such secondary structures are formed, repeats can lead to replication fork stalling even in the absence of any additional perturbation. Indeed, it was recently shown that the replication forks stall at the endogenous FMR1 locus in unaffected and FXS cells, suggesting the formation of secondary repeat structures at the FMR1 gene in vivo ...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29759891/the-putative-role-of-oxidative-stress-and-inflammation-in-the-pathophysiology-of-sleep-dysfunction-across-neuropsychiatric-disorders-focus-on-chronic-fatigue-syndrome-bipolar-disorder-and-multiple-sclerosis
#20
REVIEW
Gerwyn Morris, Brendon Stubbs, Cristiano A Köhler, Ken Walder, Anastasiya Slyepchenko, Michael Berk, André F Carvalho
Sleep and circadian abnormalities are prevalent and burdensome manifestations of diverse neuro-immune diseases, and may aggravate the course of several neuropsychiatric disorders. The underlying pathophysiology of sleep abnormalities across neuropsychiatric disorders remains unclear, and may involve the inter-play of several clinical variables and mechanistic pathways. In this review, we propose a heuristic framework in which reciprocal interactions of immune, oxidative and nitrosative stress, and mitochondrial pathways may drive sleep abnormalities across potentially neuroprogressive disorders...
April 4, 2018: Sleep Medicine Reviews
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