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https://www.readbyqxmd.com/read/28737981/contact-forces-acting-on-large-femoral-osteochondral-allografts-during-forced-knee-extension
#1
Peter Z Du, Keith L Markolf, Christopher J Lama, David R McAllister, Kristofer J Jones
BACKGROUND: A single cylindrical graft plug is commonly used for large focal femoral defects during osteochondral allograft (OCA) transplantation. Excessive contact force (CF) on a proud plug could compromise initial healing. CFs during forced knee extension are of particular interest because this maneuver is used by therapists to restore early postoperative range of motion. HYPOTHESIS: A proud OCA plug will significantly increase the CF and significantly decrease the knee extension angle (KEA)...
July 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28736868/high-modulus-low-cost-carbon-fibers-from-polyethylene-enabled-by-boron-catalyzed-graphitization
#2
Bryan E Barton, Michael J Behr, Jasson T Patton, Eric J Hukkanen, Brian G Landes, Weijun Wang, Nicholas Horstman, James E Rix, Denis Keane, Steven Weigand, Mark Spalding, Chris Derstine
Currently, carbon fibers (CFs) from the solution spinning, air oxidation, and carbonization of polyacrylonitrile impose a lower price limit of ≈$10 per lb, limiting the growth in industrial and automotive markets. Polyethylene is a promising precursor to enable a high-volume industrial grade CF as it is low cost, melt spinnable and has high carbon content. However, sulfonated polyethylene (SPE)-derived CFs have thus far fallen short of the 200 GPa tensile modulus threshold for industrial applicability. Here, a graphitization process is presented catalyzed by the addition of boron that produces carbon fiber with >400 GPa tensile modulus at 2400 °C...
July 24, 2017: Small
https://www.readbyqxmd.com/read/28735654/chronic-fatigue-syndrome-and-idiopathic-intracranial-hypertension-different-manifestations-of-the-same-disorder-of-intracranial-pressure
#3
J Nicholas P Higgins, John D Pickard, Andrew M L Lever
Though not discussed in the medical literature or considered in clinical practice, there are similarities between chronic fatigue syndrome and idiopathic intracranial hypertension (IIH) which ought to encourage exploration of a link between them. The cardinal symptoms of each - fatigue and headache - are common in the other and their multiple other symptoms are frequently seen in both. The single discriminating factor is raised intracranial pressure, evidenced in IIH usually by the sign of papilloedema, regarded as responsible for the visual symptoms which can lead to blindness...
August 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28731746/transference-of-fermi-contour-anisotropy-to-composite-fermions
#4
Insun Jo, K A Villegas Rosales, M A Mueed, L N Pfeiffer, K W West, K W Baldwin, R Winkler, Medini Padmanabhan, M Shayegan
There has been a surge of recent interest in the role of anisotropy in interaction-induced phenomena in two-dimensional (2D) charged carrier systems. A fundamental question is how an anisotropy in the energy-band structure of the carriers at zero magnetic field affects the properties of the interacting particles at high fields, in particular of the composite fermions (CFs) and the fractional quantum Hall states (FQHSs). We demonstrate here tunable anisotropy for holes and hole-flux CFs confined to GaAs quantum wells, via applying in situ in-plane strain and measuring their Fermi wave vector anisotropy through commensurability oscillations...
July 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28728128/radionuclide-biokinetics-in-the-russian-sturgeon-and-phylogenetic-consistencies-with-cartilaginous-and-bony-marine-fishes
#5
Ross A Jeffree, Scott J Markich, Francois Oberhaensli, Jean-Louis Teyssie
The biokinetics of eight radionuclides ((241)Am, (109)Cd, (134)Cs, (75)Se, (54)Mn, (110m)Ag, (65)Zn, (60)Co) absorbed from the aquatic medium by juvenile Russian sturgeon (Acipenser gueldenstaedtii) were experimentally determined in fresh (0.42‰) and brackish (9.0‰) waters, of a similar salinity range to the Caspian Sea, and in conjunction with chemical speciation modelling. Uptake and loss rate constants were determined for each radionuclide for a 14 day exposure at each salinity and during 28 days of exposure to radionuclide-free conditions...
July 17, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28722815/influence-of-morphine-and-naloxone-on-pain-modulation-in-rheumatoid-arthritis-chronic-fatigue-syndrome-fibromyalgia-and-controls-a-double-blind-randomized-placebo-controlled-cross-over-study
#6
Linda Hermans, Jo Nijs, Patrick Calders, Luc De Clerck, Greta Moorkens, Guy Hans, Sofie Grosemans, Tine Roman De Mettelinge, Joanna Tuynman, Mira Meeus
BACKGROUND: Impaired pain inhibitory and enhanced pain facilitatory mechanisms are repeatedly reported in patients with central sensitization pain. However, the exact effects of frequently prescribed opioids on central pain modulation are still unknown. METHODS: A randomized, double-blind, placebo-controlled cross-over trial was carried out. Ten CFS/FM patients, 11 RA patients and 20 controls were randomly allocated to the experimental (10 mg morphine or 0.2 mg/ml Naloxone) and placebo (2 ml Aqua) group...
July 19, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28721090/muscle-injections-with-lidocaine-improve-resting-fatigue-and-pain-in-patients-with-chronic-fatigue-syndrome
#7
Roland Staud, Taylor Kizer, Michael E Robinson
OBJECTIVE: Patients with chronic fatigue syndrome (CFS) complain of long-lasting fatigue and pain which are not relieved by rest and worsened by physical exertion. Previous research has implicated metaboreceptors of muscles to play an important role for chronic fatigue and pain. Therefore, we hypothesized that blocking impulse input from deep tissues with intramuscular lidocaine injections would improve not only the pain but also fatigue of CFS patients. METHODS: In a double-blind, placebo-controlled study, 58 CFS patients received 20 mL of 1% lidocaine (200 mg) or normal saline once into both trapezius and gluteal muscles...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28720463/incidence-rates-of-guillain-barr%C3%A3-gbs-chronic-fatigue-systemic-exertion-intolerance-disease-cfs-seid-and-postural-orthostatic-tachycardia-syndrome-pots-prior-to-introduction-of-human-papilloma-virus-hpv-vaccination-among-adolescent-girls-in-finland-2002-2012
#8
J Skufca, J Ollgren, E Ruokokoski, O Lyytikäinen, H Nohynek
BACKGROUND: In Finland a vaccination programme against human papillomavirus (HPV) was introduced in November 2013 for girls aged 11-12 years with a catchup for girls 13-15 years. Allegations that HPV vaccine is causing Guillain Barré syndrome (GBS) and non-specific diagnostic entities, such as chronic fatigue syndrome/systemic exertion intolerance disease (CFS/SEID) and postural orthostatic tachycardia syndrome (POTS), continue to surface. We examined population register-based incidence rates of CFS/SEID, GBS and POTS to provide baseline data for future HPV vaccine safety evaluations...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720104/erratum-to-altered-neuroendocrine-control-and-association-to-clinical-symptoms-in-adolescent-chronic-fatigue-syndrome-a-cross-sectional-study
#9
Vegard Bruun Wyller, Valeria Vitelli, Dag Sulheim, Even Fagermoen, Anette Winger, Kristin Godang, Jens Bollerslev
No abstract text is available yet for this article.
July 18, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28719891/serum-interleukin-10-levels-correlate-with-cerebrospinal-fluid-amyloid-beta-deposition-in-alzheimer-disease-patients
#10
Lucio D'Anna, Samir Abu-Rumeileh, Martina Fabris, Cinzia Pistis, Antonio Baldi, Nova Sanvilli, Francesco Curcio, Gian Luigi Gigli, Sebastiano D'Anna, Mariarosaria Valente
BACKGROUND AND OBJECTIVE: In Alzheimer disease (AD) inflammation becomes evident throughout the course of the disease. However, the association between inflammation, cognitive impairment, and cerebrospinal biomarkers (Aβ42, t-tau, p-tau181, and Aβ42/p-tau181 ratio) is poorly understood. METHODS: A large panel of inflammatory cytokines (interleukin [IL]-1β, IL-1ra, IL-2, IL-4, IL-6, IL-10, IL-17, interferon-γ, tumor necrosis factor-α, and vascular endothelial growth factor) was analyzed using a multiplex immunoassay in 27 patients with a diagnosis of AD dementia and in 18 control subjects...
July 19, 2017: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/28717787/a-prospective-study-of-infectious-mononucleosis-in-college-students
#11
Leonard A Jason, Ben Katz, Kristen Gleason, Stephanie McManimen, Madison Sunnquist, Taylor Thorpe
BACKGROUND: The present study aims to prospectively investigate possible biological and psychological factors present in college students who will go on to develop chronic fatigue syndrome (CFS) following Infectious Mononucleosis (IM). Identification of risk factors predisposing patients towards developing CFS may help to understand the underlying mechanisms and ultimately prevent its occurrence. Our study is enrolling healthy college students over the age of 18. Enrollment began in March of 2013 and is ongoing...
2017: Int J Psychiatry (Overl Park)
https://www.readbyqxmd.com/read/28717076/increase-in-the-regional-cerebral-blood-flow-following-waon-therapy-in-patients-with-chronic-fatigue-syndrome-a-pilot-study
#12
Takao Munemoto, Yuji Soejima, Akinori Masuda, Yoshiaki Nakabeppu, Chuwa Tei
Objective Chronic fatigue syndrome (CFS) is a complex disorder, with no consensus on therapeutic options. However, Waon therapy has been reported to be an effective treatment. The purpose of this study was to evaluate changes in the cerebral blood flow (CBF) before and after Waon therapy in CFS patients and to investigate the correlation between such changes and the therapeutic efficacy of Waon therapy. Methods Eleven patients (2 men and 9 women, mean age 27 years old) diagnosed with CFS participated in the study...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28713900/nlrc5-silencing-ameliorates-cardiac-fibrosis-by-inhibiting-the-tgf%C3%A2-%C3%AE-1-smad3-signaling-pathway
#13
Hongtao Zhou, Xuefang Yu, Guiming Zhou
The proliferation of cardiac fibroblasts (CFs) and excessive deposition of extracellular matrix are the predominant pathological characteristics of cardiac fibrosis. As the largest member of the nucleotide‑binding domain and leucine‑rich repeat (NLR) family, NLRC5 has been shown to be pivotal in the development of hepatic fibrosis. However, whether NLRC5 is involved in the pathogenesis of cardiac fibrosis remains to be elucidated. The present study aimed to investigate the role of NLRC5 and its mechanisms in regulating cardiac fibrosis...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28713879/examining-those-meeting-iom-criteria-versus-iom-plus-fibromyalgia
#14
Leonard A Jason, Stephanie McManimen, Madison Sunnquist, Julia L Newton, Elin Bolle Strand
The Institute of Medicine (IOM) recently developed clinical criteria for chronic fatigue syndrome (CFS). There might be additional criteria that could select a more homogenous and impaired group of patients, particularly those with pain. The current study focused on criteria which involved meeting the four IOM criteria, excluding medical and psychiatric co-morbidities, along with having fibromyalgia (FM). Findings indicated that those meeting the IOM clinical criteria plus FM were more impaired on a wide variety of symptoms and functional areas than those meeting on the IOM criteria or those with just 6 months of fatigue...
2017: Neurology (E-Cronicon)
https://www.readbyqxmd.com/read/28713878/access-to-medical-care-for-individuals-with-myalgic-encephalomyelitis-and-chronic-fatigue-syndrome-a-call-for-centers-of-excellence
#15
Madison Sunnquist, Laura Nicholson, Leonard A Jason, Kenneth J Friedman
The current study sought to better understand the experience of individuals with myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) in accessing care for their debilitating illness. Of 898 participants, less than half had ever seen an ME or CFS specialist, though 99% of participants were interested in specialist care. Participants cited geographic and financial barriers as most frequently precluding access to specialists. Furthermore, satisfaction with specialist care greatly exceeded satisfaction with non-specialist care...
April 2017: Mod Clin Med Res
https://www.readbyqxmd.com/read/28713856/differences-in-me-and-cfs-symptomology-in-patients-with-normal-and-abnormal-exercise-test-results
#16
Stephanie L McManimen, Leonard A Jason
Post-exertional malaise (PEM) is a cardinal symptom of myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS), which often distinguishes patients with this illness from healthy controls or individuals with exclusionary illnesses such as depression. However, occurrence rates for PEM fluctuate from subject to how the symptom is operationalized. One commonly utilized method is exercise testing, maximal or submaximal. Many patients with ME and CFS experience PEM after participating in these tests, and often show abnormal results...
2017: International Journal of Neurology and Neurotherapy
https://www.readbyqxmd.com/read/28711008/sector-wise-midpoint-characterization-factors-for-impact-assessment-of-regional-consumptive-and-degradative-water-use
#17
Chia-Chun Lin, Jia-Yu Lin, Mengshan Lee, Pei-Te Chiueh
Water availability, resulting from either a lack of water or poor water quality is a key factor contributing to regional water stress. This study proposes a set of sector-wise characterization factors (CFs), namely consumptive and degradative water stresses, to assess the impact of water withdrawals with a life cycle assessment approach. These CFs consider water availability, water quality, and competition for water between domestic, agricultural and industrial sectors and ecosystem at the watershed level. CFs were applied to a case study of regional water management of industrial water withdrawals in Taiwan to show that both regional or seasonal decrease in water availability contributes to a high consumptive water stress, whereas water scarcity due to degraded water quality not meeting sector standards has little influence on increased degradative water stress...
July 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28710068/gq-activated-fibroblasts-induce-cardiomyocyte-action-potential-prolongation-and-automaticity-in-a-3d-microtissue-environment
#18
Celinda M Kofron, Tae Yun Kim, Michelle E King, An Xie, Feng Feng, Elizabeth Park, Zhilin Qu, Bum-Rak Choi, Ulrike Mende
Cardiac fibroblasts (CFs) are known to regulate cardiomyocyte (CM) function in vivo and in 2D in vitro cultures. This study examined the effect of CF activation on the regulation of CM electrical activity in a 3D microtissue environment. Using a scaffold-free 3D platform with interspersed neonatal rat ventricular CMs and CFs, Gq-mediated signaling was selectively enhanced in CFs by Gαq adenoviral infection prior to co-seeding with CMs in non-adhesive hydrogels. After 3 days, the microtissues were analyzed by signaling assay, histological staining, quantitative PCR, Western blots, optical mapping with voltage- or calcium-sensitive dyes, and microelectrode recordings of CF resting membrane potential (RMPCF)...
July 14, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28709432/specialist-treatment-of-chronic-fatigue-syndrome-me-a-cohort-study-among-adult-patients-in-england
#19
Simon M Collin, Esther Crawley
BACKGROUND: NHS specialist chronic fatigue syndrome (CFS/ME) services in England treat approximately 8000 adult patients each year. Variation in therapy programmes and treatment outcomes across services has not been described. METHODS: We described treatments provided by 11 CFS/ME specialist services and we measured changes in patient-reported fatigue (Chalder, Checklist Individual Strength), function (SF-36 physical subscale, Work & Social Adjustment Scale), anxiety and depression (Hospital Anxiety & Depression Scale), pain (visual analogue rating), sleep (Epworth, Jenkins), and overall health (Clinical Global Impression) 1 year after the start of treatment, plus questions about impact of CFS/ME on employment, education/training and domestic tasks/unpaid work...
July 14, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28708219/one-year-efficacy-and-safety-of-0-1-cyclosporine-a-cationic-emulsion-in-the-treatment-of-severe-dry-eye-disease
#20
Christophe Baudouin, Maite Sainz de la Maza, Mourad Amrane, Jean-Sébastien Garrigue, Dahlia Ismail, Francisco C Figueiredo, Andrea Leonardi
PURPOSE: The SANSIKA study evaluated the efficacy/safety of 0.1% (1 mg/mL) cyclosporine A cationic emulsion (CsA CE) for treating dry eye disease (DED) with severe keratitis. The double-masked phase demonstrated that CsA CE was effective in reducing corneal damage and ocular surface inflammation, and was well-tolerated over 6 months. Here we report efficacy and safety findings of SANSIKA's open-label extension (OLE). METHODS: In this multicenter, double-masked, phase III study, patients with severe DED (corneal fluorescein staining [CFS] grade 4, modified Oxford scale) were randomized to once-daily CsA CE (Ikervis®) or its vehicle for 6 months, followed by 6-month open-label, once-daily CsA CE (CsA CE/CsA CE and vehicle/CsA CE groups)...
July 1, 2017: European Journal of Ophthalmology
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