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https://www.readbyqxmd.com/read/29154201/neuroendocrine-disorder-in-chronic-fatigue-syndrome
#1
Slavica Tomic, Snezana Brkic, Dajana Lendak, Daniela Maric, Milica Medic Stojanoska, Aleksandra Novakov Mikic
Background/aim: Neuroendocrine disorders are considered a possible pathogenetic mechanism in chronic fatigue syndrome (CFS). The aim of our study was to determine the function of the hypothalamic-pituitary-adrenal axis (HPA) and thyroid function in women of reproductive age suffering from CFS. Materials and methods: The study included 40 women suffering from CFS and 40 healthy women (15-45 years old). Serum levels of cortisol (0800 and 1800 hours), ACTH, total T4, total T3, and TSH were measured in all subjects...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29153536/frailty-in-hospitalized-older-adults-comparing-different-frailty-measures-in-predicting-short-and-long-term-patient-outcomes
#2
Edward Chong, Esther Ho, Jewel Baldevarona-Llego, Mark Chan, Lynn Wu, Laura Tay, Yew Yoong Ding, Wee Shiong Lim
OBJECTIVES: Data for the assessment of frailty in acutely ill hospitalized older adults remains limited. Using the Frailty Index (FI) as "gold standard," we compared (1) the diagnostic performance of 3 frailty measures (FRAIL, Clinical Frailty Scale [CFS], and Tilburg Frailty Indicator [TFI]) in identifying frailty, and (2) their ability to predict negative outcomes at 12 months after enrollment. DESIGN: Prospective cohort study. PARTICIPANTS: We recruited 210 patients (mean age 89...
November 15, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29152994/decreased-connectivity-and-increased-bold-complexity-in-the-default-mode-network-in-individuals-with-chronic-fatigue-syndrome
#3
Zack Y Shan, Kevin Finegan, Sandeep Bhuta, Timothy Ireland, Donald R Staines, Sonya M Marshall-Gradisnik, Leighton R Barnden
The chronic fatigue syndrome / myalgic encephalomyelitis (CFS) is a debilitating disease with unknown pathophysiology and no diagnostic test. This study investigated the default mode network (DMN) in order to understand the pathophysiology of CFS and to identify potential biomarkers. Using functional MRI (fMRI) collected from 72 subjects (45 CFS and 27 controls) with a temporal resolution of 0.798s, we evaluated the default mode network using static functional connectivity (FC), dynamic functional connectivity (DFC) and DFC complexity, blood oxygenation level dependent (BOLD) activation maps and complexity of activity...
November 20, 2017: Brain Connectivity
https://www.readbyqxmd.com/read/29138860/an-rna%C3%A2-sequencing-study-identifies-candidate-genes-for-angiotensin-ii%C3%A2-induced-cardiac-remodeling
#4
Jin Shu, Zhanwen Liu, Li Jin, Haiya Wang
The present study aimed to reveal the underlying mechanism of angiotensin II (AngII)‑induced cardiac remodeling and to identify potential therapeutic targets for prevention. Rat cardiac fibroblasts (CFs) were cultured with 10 nM AngII for 12 h, and CFs without AngII were used as the control. Following RNA isolation from AngII treated and control CFs, RNA‑sequencing was performed to detect gene expression levels. Differentially‑expressed genes (DEGs) were identified using the linear models for microarray analysis package in R software, and their functions and pathways were examined via enrichment analysis...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29136449/does-this-patient-have-acute-mountain-sickness-the-rational-clinical-examination-systematic-review
#5
David Meier, Tinh-Hai Collet, Isabella Locatelli, Jacques Cornuz, Bengt Kayser, David L Simel, Claudio Sartori
Importance: Acute mountain sickness (AMS) affects more than 25% of individuals ascending to 3500 m (11 500 ft) and more than 50% of those above 6000 m (19 700 ft). AMS may progress from nonspecific symptoms to life-threatening high-altitude cerebral edema in less than 1% of patients. It is not clear how to best diagnose AMS. Objective: To systematically review studies assessing the accuracy of AMS diagnostic instruments, including the visual analog scale (VAS) score, which quantifies the overall feeling of sickness at altitude (VAS[O]; various thresholds), Acute Mountain Sickness-Cerebral score (AMS-C; ≥0...
November 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29133662/a-tiny-tick-can-cause-a-big-health-problem
#6
Manuel John, M Raman, Keith Ryan
Ticks are tiny crawling bugs in the spider family that feed by sucking blood from animals. They are second only to mosquitoes as vectors of human disease, both infectious and toxic. Infected ticks spread over a hundred diseases, some of which are fatal if undetected. They spread the spirochete (which multiplies in the insect's gut) with a subsequent bite to the next host. We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29133321/can-physical-assessment-techniques-aid-diagnosis-in-people-with-chronic-fatigue-syndrome-myalgic-encephalomyelitis-a-diagnostic-accuracy-study
#7
Lucy Hives, Alice Bradley, Jim Richards, Chris Sutton, James Selfe, Bhaskar Basu, Kerry Maguire, Gail Sumner, Tarek Gaber, Annice Mukherjee, Raymond N Perrin
OBJECTIVE: To assess five physical signs to see whether they can assist in the screening of patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and potentially lead to quicker treatment. METHODS: This was a diagnostic accuracy study with inter-rater agreement assessment. Participants recruited from two National Health Service hospitals, local CFS/ME support groups and the community were examined by three practitioners on the same day in a randomised order...
November 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/29131969/maternal-communicative-functions-and-mind-mindedness-at-16-months-as-predictors-of-children-s-internal-and-non-internal-language-at-20-months
#8
Emiddia Longobardi, Pietro Spataro, Cristina Colonnesi
The effects of Communicative functions and Mind-Mindedness on children's language development have been typically investigated in separate studies. The present longitudinal research was therefore designed to yield new insight into the simultaneous impact of these two dimensions of maternal responsiveness on the acquisition of expressive language skills in a sample of 25 mother-child dyads. The frequencies of five communicative functions (Tutorial, Didactic, Conversational, Control and Asynchronous) and two types of mind-related comments (attuned vs...
November 10, 2017: Infant Behavior & Development
https://www.readbyqxmd.com/read/29127316/exercise-induced-changes-in-cerebrospinal-fluid-mirnas-in-gulf-war-illness-chronic-fatigue-syndrome-and-sedentary-control-subjects
#9
James N Baraniuk, Narayan Shivapurkar
Gulf War Illness (GWI) and Chronic Fatigue Syndrome (CFS) have similar profiles of pain, fatigue, cognitive dysfunction and exertional exhaustion. Post-exertional malaise suggests exercise alters central nervous system functions. Lumbar punctures were performed in GWI, CFS and control subjects after (i) overnight rest (nonexercise) or (ii) submaximal bicycle exercise. Exercise induced postural tachycardia in one third of GWI subjects (Stress Test Activated Reversible Tachycardia, START). The remainder were Stress Test Originated Phantom Perception (STOPP) subjects...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29119317/prodigiosin-violacein-and-volatile-organic-compounds-produced-by-widespread-cutaneous-bacteria-of-amphibians-can-inhibit-two-batrachochytrium-fungal-pathogens
#10
Douglas C Woodhams, Brandon C LaBumbard, Kelly L Barnhart, Matthew H Becker, Molly C Bletz, Laura A Escobar, Sandra V Flechas, Megan E Forman, Anthony A Iannetta, Maureen D Joyce, Falitiana Rabemananjara, Brian Gratwicke, Miguel Vences, Kevin P C Minbiole
Symbiotic bacteria can produce secondary metabolites and volatile compounds that contribute to amphibian skin defense. Some of these symbionts have been used as probiotics to treat or prevent the emerging disease chytridiomycosis. We examined 20 amphibian cutaneous bacteria for the production of prodigiosin or violacein, brightly colored defense compounds that pigment the bacteria and have characteristic spectroscopic properties making them readily detectable, and evaluated the antifungal activity of these compounds...
November 9, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/29118054/vitamin-d-status-in-chronic-fatigue-syndrome-myalgic-encephalomyelitis-a-cohort-study-from-the-north-west-of-england
#11
Kate E Earl, Giorgos K Sakellariou, Melanie Sinclair, Manuel Fenech, Fiona Croden, Daniel J Owens, Jonathan Tang, Alastair Miller, Clare Lawton, Louise Dye, Graeme L Close, William D Fraser, Anne McArdle, Michael B J Beadsworth
OBJECTIVE: Severe vitamin D deficiency is a recognised cause of skeletal muscle fatigue and myopathy. The aim of this study was to examine whether chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with altered circulating vitamin D metabolites. DESIGN: Cohort study. SETTING: UK university hospital, recruiting from April 2014 to April 2015. PARTICIPANTS: Ninety-two patients with CFS/ME and 94 age-matched healthy controls (HCs)...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29116663/higher-contact-force-energy-setting-and-impedance-rise-during-radiofrequency-ablation-predicts-charring-new-insights-from-contact-force-guided-in-vivo-ablation
#12
Hisaki Makimoto, Andreas Metzner, Roland Richard Tilz, Tina Lin, Christian-H Heeger, Andreas Rillig, Shibu Mathew, Christine Lemeš, Erik Wissner, Karl-Heinz Kuck, Feifan Ouyang
INTRODUCTION: Higher contact force (CF) theoretically increases the risk of blood charring, diminishing lesion formation. We aimed to investigate the relationship between CF, impedance change and char formation during pulmonary vein isolation (PVI). METHODS: CF was assessed during PVI in 65 patients. Radiofrequency ablation (RFA) with power-controlled mode was applied in the point-by-point manner. The RFA were divided into 5 groups: group-A [CF < 10 g], group-B (10 g≤CF < 20 g), group-C (20 g≤CF < 30 g), group-D (30 g≤CF < 40 g), and group-E (CF≥40 g)...
November 8, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29114002/sdf-1%C3%AE-stromal-cell-derived-factor-1%C3%AE-induces-cardiac-fibroblasts-renal-microvascular-smooth-muscle-cells-and-glomerular-mesangial-cells-to-proliferate-cause-hypertrophy-and-produce-collagen
#13
Edwin K Jackson, Yumeng Zhang, Delbert D Gillespie, Xiao Zhu, Dongmei Cheng, Travis C Jackson
BACKGROUND: Activated cardiac fibroblasts (CFs), preglomerular vascular smooth muscle cells (PGVSMCs), and glomerular mesangial cells (GMCs) proliferate, cause hypertrophy, and produce collagen; in this way, activated CFs contribute to cardiac fibrosis, and activated PGVSMCs and GMCs promote renal fibrosis. In heart and kidney diseases, SDF-1α (stromal cell-derived factor 1α; endogenous CXCR4 [C-X-C motif chemokine receptor 4] receptor agonist) levels are often elevated; therefore, it is important to know whether and how the SDF-1α/CXCR4 axis activates CFs, PGVSMCs, or GMCs...
November 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29113826/ghrelin-suppresses-cardiac-fibrosis-of-post-myocardial-infarction-heart-failure-rats-by-adjusting-the-activin-a-follistatin-imbalance
#14
Chunyan Yang, Jinsha Liu, Kai Liu, Beibei Du, Kaiyao Shi, Mei Ding, Bing Li, Ping Yang
Ghrelin, a growth hormone-releasing peptide, potentially improves cardiac function, but the mechanisms remain unclear. In the study, the rat heart failure (HF) model was established by ligating the left anterior descending coronary artery (LAD) and treated with ghrelin (100μg/kg, subcutaneous injection, bid); neonatal rat cardiomyocytes were cultured and stimulated with Ang II (0.1μM) and ghrelin(0.1μM) to explore the underlying mechanism of ghrelin in myocardial remodeling. Hemodynamic changes and serum brain natriuretic peptide (BNP) concentrations were measured to assess cardiac function...
November 4, 2017: Peptides
https://www.readbyqxmd.com/read/29111893/-psychological-health-of-children-with-chronic-physical-illness-and-their-parents-results-from-meta-analyses
#15
Martin Pinquart
Psychological Health of Children with Chronic Physical Illness and their Parents - Results from Meta-Analyses The present paper summarizes results from meta-analyses on psychological well-being of children with chronic physical illnesses and their parents. At the beginning, we discuss potential reasons for psychological effects of a chronic physical illness on children and adolescents as well as their parents. We then summarize results of meta-analyses of studies that compared aspects of mental health of children with a chronic physical illness and their parents with families of healthy children...
November 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/29111359/role-of-spontaneous-brain-activity-in-explicit-and-implicit-aspects-of-cognitive-flexibility-under-socially-conflicting-situations-a-resting-state-fmri-study-using-fractional-amplitude-of-low-frequency-fluctuations
#16
Junya Fujino, Shisei Tei, Kathryn F Jankowski, Ryosaku Kawada, Toshiya Murai, Hidehiko Takahashi
We are constantly exposed to socially conflicting situations in everyday life, and cognitive flexibility is essential for adaptively coping with such difficulties. Flexible goal choice and pursuit are not exclusively conscious, and therefore cognitive flexibility involves both explicit and implicit forms of processing. However, it is unclear how individual differences in explicit and implicit aspects of flexibility are associated with neural activity in a resting state. Here, we measured intrinsic fractional amplitude of low-frequency fluctuations (fALFF) by resting-state functional magnetic resonance imaging (RS-fMRI) as an indicator of regional brain spontaneous activity, together with explicit and implicit aspects of cognitive flexibility using the Cognitive Flexibility Scale (CFS) and Implicit Association Test (IAT)...
October 27, 2017: Neuroscience
https://www.readbyqxmd.com/read/29107194/anti-aflatoxigenic-effect-of-organic-acids-produced-by-lactobacillus-plantarum
#17
Ana Guimarães, Ana Santiago, José A Teixeira, Armando Venâncio, Luís Abrunhosa
Lactic acid bacteria (LAB), which are commonly used in the production of fermented foods, have been gaining attention for their antifungal and antimycotoxin properties. In this work, the strain Lactobacillus plantarum UM55 was selected among other LAB for inhibiting the growth of Aspergillus flavus. Further, it is shown that cell-free supernatant (CFS) of this strain inhibits the production of aflatoxins (AFLs) by 91%. This inhibition was dependent on CFS pH, increased with increasing concentrations of CFS, and was independent of fungal growth, which was inhibited only by 32%...
January 2, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29105390/dual-effects-of-cell-free-supernatants-from-lactobacillus-acidophilus-and-lactobacillus-rhamnosus-gg-in-regulation-of-mmp-9-by-up-regulating-timp-1-and-down-regulating-cd147-in-pmadifferentiated-thp-1-cells
#18
Faezeh Maghsood, Abbas Mirshafiey, Mohadese M Farahani, Mohammad Hossein Modarressi, Parvaneh Jafari, Elahe Motevaseli
OBJECTIVES: Recent studies have reported dysregulated expression of matrix metalloproteinases (MMPs), especially MMP-2, MMP-9, tissue inhibitor of metalloproteinase-1, -2 (TIMP-1, TIMP-2), and extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in activated macrophages of patients with inflammatory diseases. Therefore, MMP-2, MMP-9, and their regulators may represent a new target for treatment of inflammatory diseases. Probiotics, which are comprised of lactic acid bacteria, have the potential to modulate inflammatory responses...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29104961/a-comparison-of-case-definitions-for-myalgic-encephalomyelitis-and-chronic-fatigue-syndrome
#19
Madison Sunnquist, Leonard A Jason, Pamela Nehrke, Ellen M Goudsmit
Many professionals have described the clinical presentation of myalgic encephalomyelitis (ME), but recent efforts have focused on the development of ME criteria that can be reliably applied. The current study compared the symptoms and functioning of individuals who met the newly-developed Institute of Medicine (IOM) clinical criteria to a revised version of the London criteria for ME. While 76% of a sample diagnosed with chronic fatigue syndrome (CFS) met the IOM criteria, 44% met the revised London criteria...
2017: J Chronic Dis Manag
https://www.readbyqxmd.com/read/29104653/naringenin-inhibits-transforming-growth-factor-%C3%AE-1-induced-cardiac-fibroblast-proliferation-and-collagen-synthesis-via-g0-g1-arrest
#20
Mingxin Liu, Xiping Xu, Jianhua Zhao, Yanhong Tang
The Traditional Chinese Medicine naringenin (NRG) has a number of biological effects, including anti-inflammatory, anti-oxidative, anti-tumor and anti-atherosclerotic effects. However, the mechanism underlying its effects remains unclear. The aim of the present study is to investigate the role and mechanism of NRG on proliferation and collagen synthesis of cardiac fibroblasts (CFs) induced by transforming growth factor β1 (TGF-β1). Firstly, proliferation and collagen synthesis in CFs subjected to TGF-β1 was assessed subsequent to the consumption of NRG or control treatment...
November 2017: Experimental and Therapeutic Medicine
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