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https://www.readbyqxmd.com/read/28320179/multimodal-and-simultaneous-assessments-of-brain-and-spinal-fluid-abnormalities-in-chronic-fatigue-syndrome-and-the-effects-of-psychiatric-comorbidity
#1
Benjamin H Natelson, Xiangling Mao, Aaron J Stegner, Gudrun Lange, Diana Vu, Michelle Blate, Guoxin Kang, Eli Soto, Tolga Kapusuz, Dikoma C Shungu
The purpose of this study was to investigate whether CFS patients without comorbid psychiatric diagnoses differ from CFS patients with comorbid psychiatric diagnoses and healthy control subjects in neuropsychological performance, the proportion with elevated spinal fluid protein or white cell counts, cerebral blood flow (CBF), brain ventricular lactate and cortical glutathione (GSH). The results of the study did not show any differences in any of the outcome measures between CFS patients with and without psychiatric comorbidity, thus indicating that psychiatric status may not be an exacerbating factor in CFS...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319363/real-time-observation-of-the-electrode-size-dependent-evolution-dynamics-of-the-conducting-filaments-in-a-sio2-layer
#2
Fang Yuan, Zhi Zhang, Chunru Liu, Feichi Zhou, Hei Man Yau, Wei Lu, Xiaoyan Qiu, H-S Philip Wong, Jiyan Dai, Yang Chai
Conducting bridge random access memory (CBRAM) is one of the most promising candidates for future nonvolatile memories. It is important to understand the scalability and retention of CBRAM cells to realize better memory performance. Here, we directly observe the switching dynamics of Cu tip/SiO2/W cells with various active electrode sizes using in situ transmission electron microscopy. Conducting filaments (CFs) grow from the active electrode (Cu tip) to inert electrode (W) during the SET operations. The size of the Cu tip affects the electric-field distribution, the amount of the cation injection into electrolyte, and the dimension of the CF...
March 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28315522/human-cardiac-fibroblasts-adaptive-responses-to-controlled-combined-mechanical-strain-and-oxygen-changes-in-vitro
#3
Giovanni Stefano Ugolini, Andrea Pavesi, Marco Rasponi, Gianfranco Beniamino Fiore, Roger Kamm, Monica Soncini
Upon cardiac pathological conditions such as ischemia, microenvironmental changes instruct a series of cellular responses that trigger cardiac fibroblasts-mediated tissue adaptation and inflammation. A comprehensive model of how early environmental changes may induce cardiac fibroblasts (CF) pathological responses is far from being elucidated, partly due to the lack of approaches involving complex and simultaneous environmental stimulation. Here, we provide a first analysis of human primary CF behavior by means of a multi-stimulus microdevice for combined application of cyclic mechanical strain and controlled oxygen tension...
March 18, 2017: ELife
https://www.readbyqxmd.com/read/28314549/do-changes-in-illness-perceptions-physical-activity-and-behavioural-regulation-influence-fatigue-severity-and-health-related-outcomes-in-cfs-patients
#4
V De Gucht, F K Garcia, M den Engelsman, S Maes
OBJECTIVE: Examine to what extent changes in cognitions and changes in physical activity and behavioural regulation patterns influence fatigue severity, physical symptoms, and physical and psychological functioning of patients suffering from Chronic Fatigue Syndrome (CFS) at follow-up. METHODS: The present study is an observational longitudinal study with a 12-month follow-up. A total of 144 CFS patients participated both at baseline and at follow-up. Four separate hierarchical regression analyses were conducted with fatigue, physical symptoms, physical functioning and psychological functioning at follow-up as the dependent variables, and (changes in) illness perceptions and behavioural regulation patterns (all-or-nothing and limiting behaviour) as the independent variables...
April 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28314518/the-interface-between-chronic-fatigue-syndrome-and-depression-a-psychobiological-and-neurophysiological-conundrum
#5
Derek Larkin, Colin R Martin
The chronic fatigue syndrome (CFS) remains a contentious and controversial presentation despite decades of systematic research from a variety of medical specialties and associated disciplines. Variously championed as a condition of immunological, neurological, neurophysiological, psychiatric or psychological origin, consensus on a cogent and evidenced-based pathway has yet to be achieved. Irrespective of the ambiguity regarding aetiology, what is incontrovertible is the experience of significant depression, which often accompanies this most distressing clinical presentation...
March 14, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28304247/effects-of-chronic-diurnal-disruption-and-acute-inflammatory-challenge-on-mice-with-latent-murine-gammaherpesvirus-infection
#6
Rita A Trammell, Linda A Toth
People who engage in shift work (SW) have increased risk of developing illnesses, including infectious diseases and various inflammatory conditions. We hypothesized that exposure to repeated cycles of diurnal disruption, mimicking SW, influences viral clearance, latent viral load, or viral reactivation from latency in mice infected with murine gammaherpesvirus (MuGHV). To test this idea, we inoculated BALB/cByJ and C.129S7(B6)-Ifng tm1Ts/J (IFNgKO) mice with MuGHV and housed them under either a stable light:dark (LD) cycle or one mimicking SW...
December 1, 2016: Comparative Medicine
https://www.readbyqxmd.com/read/28303641/myalgic-encephalomyelitis-chronic-fatigue-syndrome-and-gulf-war-illness-patients-exhibit-increased-humoral-responses-to-the-herpesviruses-encoded-dutpase-implications-in-disease-pathophysiology
#7
Peter Halpin, Marshall Vance Williams, Nancy G Klimas, Mary Ann Fletcher, Zachary Barnes, Maria Eugenia Ariza
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) are debilitating diseases with overlapping symptomology and there are currently no validated tests for definitive diagnosis of either syndrome. While there is evidence supporting the premise that some herpesviruses may act as possible triggers of ME/CFS, the involvement of herpesviruses in the pathophysiology of GWI has not been studied in spite of a higher prevalence of ME/CFS in these patients. We have previously demonstrated that the deoxyuridine triphosphate nucleotidohydrolases (dUTPase) encoded by Epstein-Barr virus (EBV), human herpesvirus-6 (HHV-6), and varicella-zoster virus (VZV) possess novel functions in innate and adaptive immunity...
March 17, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28302751/impact-of-the-clinical-frailty-scale-on-outcomes-after-transcatheter-aortic-valve-replacement
#8
Tetsuro Shimura, Masanori Yamamoto, Seiji Kano, Ai Kagase, Atsuko Kodama, Yutaka Koyama, Etsuo Tsuchikane, Takahiko Suzuki, Toshiaki Otsuka, Shun Kohsaka, Norio Tada, Futoshi Yamanaka, Toru Naganuma, Motoharu Araki, Shinichi Shirai, Yusuke Watanabe, Kentaro Hayashida
Background -The semi-quantitative clinical frailty scale (CFS) is a simple tool to assess patient`s frailty and has been shown to correlate with mortality in elderly patients even when evaluated by non-geriatricians. The aim of the current study was to determine the prognostic value of CFS in patients who underwent transcatheter aortic valve replacement (TAVR). Methods -We utilized the Optimized CathEter vAlvular iNtervention (OCEAN) Japanese multicenter registry to review data of 1215 patients who underwent TAVR...
March 16, 2017: Circulation
https://www.readbyqxmd.com/read/28302133/activin-b-is-a-novel-biomarker-for-chronic-fatigue-syndrome-myalgic-encephalomyelitis-cfs-me-diagnosis-a-cross-sectional-study
#9
Brett A Lidbury, Badia Kita, Donald P Lewis, Susan Hayward, Helen Ludlow, Mark P Hedger, David M de Kretser
BACKGROUND: Investigations of activin family proteins as serum biomarkers for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). CFS/ME is a disease with complex, wide-ranging symptoms, featuring persistent fatigue of 6 months or longer, particularly post exertion. No definitive biomarkers are available. METHODS: A cross-sectional, observational study of CFS/ME patients fulfilling the 2003 Canadian Consensus Criteria, in parallel with healthy non-fatigued controls, was conducted...
March 16, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28302057/clinically-proven-mtdna-mutations-are-not-common-in-those-with-chronic-fatigue-syndrome
#10
Elizna M Schoeman, Francois H Van Der Westhuizen, Elardus Erasmus, Etresia van Dyk, Charlotte V Y Knowles, Shereen Al-Ali, Wan-Fai Ng, Robert W Taylor, Julia L Newton, Joanna L Elson
BACKGROUND: Chronic Fatigue Syndrome (CFS) is a prevalent debilitating condition that affects approximately 250,000 people in the UK. There is growing interest in the role of mitochondrial function and mitochondrial DNA (mtDNA) variation in CFS. It is now known that fatigue is common and often severe in patients with mitochondrial disease irrespective of their age, gender or mtDNA genotype. More recently, it has been suggested that some CFS patients harbour clinically proven mtDNA mutations...
March 16, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28300371/energy-dependence-and-angular-dependence-of-an-optically-stimulated-luminescence-dosimeter-in-the-mammography-energy-range
#11
Ai Kawaguchi, Yuta Matsunaga, Shoichi Suzuki, Koichi Chida
This study aimed to investigate the energy dependence and the angular dependence of commercially available optically stimulated luminescence (OSL) point dosimeters in the mammography energy range. The energy dependence was evaluated to calculate calibration factors (CFs). The half-value layer range was 0.31-0.60 mmAl (Mo/Mo 22-28 kV, Mo/Rh 28-32 kV, and W/Rh 30-34 kV at 2-kV intervals). Mo/Rh 28 kV was the reference condition. Angular dependence was tested by rotating the X-ray tube from -90° to 90° in 30° increments, and signal counts from angled nanoDots were normalized to the 0° signal counts...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295128/medically-unexplained-physical-symptoms-mups-among-adults-in-canada-comorbidity-health-care-use-and-employment
#12
Jungwee Park, Heather Gilmour
Based on data from the 2014 Canadian Community Health Survey and the 2012 Canadian Community Health Survey-Mental Health, this study provides estimates of the prevalence of medically unexplained physical symptoms (MUPS) in the household population aged 25 or older. MUPS are examined in relation to sociodemographic characteristics, physical and mental comorbidity, health care use and unmet needs, labour force participation and productivity. In 2014, 5.5% of Canadian adults-an estimated 1.3 million - reported having chronic fatigue syndrome (1...
March 15, 2017: Health Reports
https://www.readbyqxmd.com/read/28294304/il-21-promotes-myocardial-ischemia-reperfusion-injury-through-the-modulation-of-neutrophil-infiltration
#13
Kejing Wang, Shuang Wen, Jiao Jiao, Tingting Tang, Xin Zhao, Min Zhang, Bingjie Lv, Yuzhi Lu, Xingdi Zhou, Jingyong Li, Shaofang Nie, Yuhua Liao, Qing Wang, Xin Tu, Ziad Mallat, Ni Xia, Xiang Cheng
BACKGROUND AND PURPOSE: The immune system plays important roles in driving the acute inflammatory response following myocardial ischemia/reperfusion injury (MIRI). Interleukin-21 (IL-21) is a pleiotropic cytokine with multiple immunomodulatory effects and its role in MIRI remains unknown. EXPERIMENTAL APPROACH: Myocardial injury, neutrophil infiltration and expressions of neutrophil chemokines keratinocyte-derived chemokine (KC) and macrophage inflammatory protein-2 (MIP-2) were studied in a mouse model of MIRI...
March 14, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28283343/structural-roles-of-calcium-in-alkaline-and-alkaline-earth-aluminosilicate-glasses-by-solid-state-43-ca-17-o-and-27-al-nmr
#14
Koji Kanehashi
Structural roles of Ca in aluminosilicate glasses have been investigated by solid-state (43)Ca, (17)O, and (27)Al NMR spectroscopy. In 15Al2O3-55SiO2-15CaO-15RO (R=Mg, Ca, Sr, and Na2) (mol%) glass systems wherein half of the alkaline plus alkaline-earth cations charge-compensate (AlO4)(‒) tetrahedra and the other half modify the glass network, with decreasing cation field strength (CFS) in the order of Mg(2+)>Ca(2+)>Sr(2+)>Na(+), the isotropic chemical shift (δiso) of (43)Ca moves to a higher frequency and the quadrupolar coupling constant (PQ) of (43)Ca decreases...
March 3, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/28280741/the-correlation-base-selection-algorithm-for-diagnostic-schizophrenia-based-on-blood-based-gene-expression-signatures
#15
Hang Zhang, Ziyang Xie, Yuwen Yang, Yizhen Zhao, Bao Zhang, Jing Fang
Microarray analysis of gene expression is often used to diagnose different types of disease. Many studies report remarkable achievements in nervous system disease. Clinical diagnosis of schizophrenia (SCZ) still depends on doctors' experience, which is unreliable and needs to be more objective and quantified. To solve this problem, we collected whole blood gene expression data from four studies, including 152 individuals with schizophrenia (SCZ) and 138 normal controls in different regions. The correlation-based feature selection (CFS, one of the machine learning methods) algorithm was applied in this study, and 103 significantly differentially expressed genes between patients and controls, called "feature genes," were selected; then, a model for SCZ diagnosis was built...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28279972/prevalence-and-factors-associated-with-the-use-of-acupuncture-and-chinese-medicine-results-of-a-nationally-representative-survey-of-17%C3%A2-161-australian-women
#16
Lu Yang, Jon Adams, David Sibbritt
BACKGROUND: Traditional Chinese Medicine has considerable public support in Australia and elsewhere around the world; the literature suggests Chinese medicine (CM) and acupuncture are particularly popular. AIM: To examine factors associated with CM/acupuncture use among young/middle-aged Australian women. METHODS: This research formed part of the Australian Longitudinal Study on Women's Health (ALSWH), a population-based cohort study. Data were obtained from the 'young' (34-39 years; n=8010) and 'middle-aged' (62-67 years; n=9151) ALSWH cohorts, who completed survey 6 (in 2012) and survey 7 (in 2013), respectively...
March 9, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/28276066/stress-vulnerability-in-adolescents-with-chronic-fatigue-syndrome-experimental-study-investigating-heart-rate-variability-and-skin-conductance-responses
#17
Katharine A Rimes, Kate Lievesley, Trudie Chalder
BACKGROUND: Stress vulnerability has been implicated in adolescent chronic fatigue syndrome (CFS), but has rarely been investigated directly. This study compared psychological and physiological responses to a laboratory social performance task in adolescents with CFS with chronic illness (asthma) and healthy control groups. METHODS: Adolescents with CFS (n = 60), adolescents with asthma (n = 31) and healthy adolescents (n = 78) completed questionnaires before and after a social performance task...
March 9, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28275316/cohort-description-the-danish-study-of-functional-disorders
#18
Thomas Meinertz Dantoft, Jeanette Frost Ebstrup, Allan Linneberg, Sine Skovbjerg, Anja Lykke Madsen, Jesper Mehlsen, Louise Brinth, Lene Falgaard Eplov, Tina Wisbech Carstensen, Andreas Schroder, Per Klausen Fink, Erik Lykke Mortensen, Torben Hansen, Oluf Pedersen, Torben Jørgensen
The Danish study of Functional Disorders (DanFunD) cohort was initiated to outline the epidemiology of functional somatic syndromes (FSS) and is the first larger coordinated epidemiological study focusing exclusively on FSS. FSS are prevalent in all medical settings and can be defined as syndromes that, after appropriate medical assessment, cannot be explained in terms of a conventional medical or surgical disease. FSS are frequent and the clinical importance varies from vague symptoms to extreme disability...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28275109/intermittent-and-graded-exercise-effects-on-nk-cell-degranulation-markers-lamp-1-lamp-2-and-cd8-cd38-in-chronic-fatigue-syndrome-myalgic-encephalomyelitis
#19
Suzanne Broadbent, Rosanne Coutts
There is substantial evidence of immune system dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) but little is understood of exercise training effects on lymphocyte function in this illness. This study investigated whether graded and intermittent exercise improved CD8(+) lymphocyte activation and natural killer cell degranulation markers compared to no exercise. Twenty-four chronic fatigue syndrome (CFS) patients (50.2 ± 10 year) were randomized to graded exercise (GE), intermittent exercise (IE) or usual care (UC) groups; a control group (CTL) of 18 matched sedentary non-CFS/ME participants were included for immunological variable comparisons...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28274290/same-same-but-different-cognitive-behavioural-treatment-approaches-for-paediatric-cfs-me-and-depression
#20
M E Loades, T Chalder
BACKGROUND: Approximately one in three children and young people with chronic fatigue syndrome (CFS/ME) also have probable depression. Cognitive behaviour therapy (CBT) has a growing evidence base as an effective treatment approach for CFS/ME and for depression in this population. AIMS: Given the high degree of co-morbidity, this discussion paper aims to compare and contrast CBT for CFS/ME and CBT for depression in children and young people. METHOD: The existing literature on CBT for depression and CBT for CFS/ME, in relation to children and young people was reviewed...
March 9, 2017: Behavioural and Cognitive Psychotherapy
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