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https://www.readbyqxmd.com/read/28691719/narcolepsy-type-1-and-hypersomnia-associated-with-a-psychiatric-disorder-show-different-slow-wave-activity-dynamics
#1
Ewa Walacik-Ufnal, Anna Justyna Piotrowska, Dorota Wołyńczyk-Gmaj, Piotr Januszko, Bartłomiej Gmaj, Marcin Ufnal, Marek Kabat, Marcin Wojnar
The aim of the study was to compare electrophysiological parameters of night sleep in narcolepsy type 1 and hypersomnia associated with a psychiatric disorder. Fortyfour patients: 15 with narcolepsy type 1, 14 with hypersomnia associated with a psychiatric disorder and 15 age- and sex-matched controls participated in the study. The study subjects filled in the Athens Insomnia Scale (AIS) and the Beck Depression Inventory (BDI). The severity of daytime sleepiness was quantified subjectively using the Epworth Sleepiness Scale (ESS) and the Stanford Sleepiness Scale (SSS), and objectively using the Multiple Sleep Latency Test (MSLT)...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/28656904/mapping-quorum-sensing-onto-neural-networks-to-understand-collective-decision-making-in-heterogeneous-microbial-communities
#2
Tahir I Yusufaly, James Q Boedicker
Microbial communities frequently communicate via quorum sensing (QS), where cells produce, secrete, and respond to a threshold level of an autoinducer (AI) molecule, thereby modulating gene expression. However, the biology of QS remains incompletely understood in heterogeneous communities, where variant bacterial strains possess distinct QS systems that produce chemically unique AIs. AI molecules bind to 'cognate' receptors, but also to 'non-cognate' receptors found in other strains, resulting in inter-strain crosstalk...
July 19, 2017: Physical Biology
https://www.readbyqxmd.com/read/28631747/optimization-of-the-mean-arterial-pressure-and-timing-of-surgical-decompression-in-traumatic-spinal-cord-injury-a-retrospective-study
#3
A Dakson, D Brandman, G Thibault-Halman, S D Christie
STUDY DESIGN: A retrospective comparative study. OBJECTIVES: This study aims to investigate the extent to which early surgical decompression and maintenance of MAP ⩾85 mm Hg for 5 days postinjury affected neurological recovery utilizing internal controls for comparison of outcomes in patients with traumatic spinal cord injury. SETTING: Acute trauma center, Halifax, Nova Scotia, Canada. METHODS: We identified 94 cases of traumatic SCI...
June 20, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28458968/the-aesthetic-items-scale-a-tool-for-the-evaluation-of-aesthetic-outcome-after-breast-reconstruction
#4
Rieky E G Dikmans, Lauren E H Nene, Mark-Bram Bouman, Henrica C W de Vet, Marc A M Mureau, Marlon E Buncamper, Hay A H Winters, Marco J P F Ritt, Margriet G Mullender
BACKGROUND: Valid tools to assess aesthetic outcomes after breast reconstructive surgery are scarce. Previously a professional aesthetic assessment scale was introduced, the Aesthetic Items Scale (AIS). We aim to determine if this method is a valid and reliable tool to assess aesthetic outcome after breast reconstructive surgery. METHODS: The study population was consenting women who underwent prophylactic mastectomy with subsequent implant-based breast reconstruction...
March 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28414745/mapping-the-srs-22r-questionnaire-onto-the-eq-5d-5l-utility-score-in-patients-with-adolescent-idiopathic-scoliosis
#5
Carlos King Ho Wong, Prudence Wing Hang Cheung, Dino Samartzis, Keith Dip-Kei Luk, Kenneth M C Cheung, Cindy Lo Kuen Lam, Jason Pui Yin Cheung
This is a prospective study to establish prediction models that map the refined Scoliosis Research Society 22-item (SRS-22r) onto EuroQoL-5 dimension 5-level (EQ-5D-5L) utility scores in adolescent idiopathic scoliosis (AIS) patients. Comparison of treatment outcomes in AIS can be determined by cost-utility analysis. However, the mainstay spine-specific health-related quality of life outcome measure, the SRS-22r questionnaire does not provide utility assessment. In this study, AIS patients were prospectively recruited to complete both the EQ-5D-5L and SRS-22r questionnaires by trained interviewers...
2017: PloS One
https://www.readbyqxmd.com/read/28404769/a-decrease-in-blood-pressure-is-associated-with-unfavorable-outcome-in-patients-undergoing-thrombectomy-under-general-anesthesia
#6
Kilian M Treurniet, Olvert A Berkhemer, Rogier V Immink, Hester F Lingsma, Vivian M C Ward-van der Stam, Markus W Hollmann, Jaap Vuyk, Wim H van Zwam, Aad van der Lugt, Robert J van Oostenbrugge, Diederik W J Dippel, Jonathan M Coutinho, Yvo B W E M Roos, Henk A Marquering, Charles B L M Majoie
BACKGROUND: Up to two-thirds of patients are either dependent or dead 3 months after thrombectomy for acute ischemic stroke (AIS). Loss of cerebral autoregulation may render patients with AIS vulnerable to decreases in mean arterial pressure (MAP). OBJECTIVE: To determine whether a fall in MAP during intervention under general anesthesia (GA) affects functional outcome. METHODS: This subgroup analysis included patients from the MR CLEAN trial treated with thrombectomy under GA...
April 12, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28328677/genitourinary-injuries-after-traffic-accidents-analysis-of-a-registry-of-162-690-victims
#7
Jean-Etienne Terrier, Philippe Paparel, Blandine Gadegbeku, Alain Ruffion, Lawrence C Jenkins, Amina N'Diaye
BACKGROUND: Traffic accidents are the most frequent cause of genitourinary injuries (GUI). Kidney injuries after trauma have been well described. However, there exists a paucity of data on other traumatic GUI after traffic accidents. The objective of this study was to analyze the frequency and type of all GUI, by user category, after traffic accidents. METHODS: Patient cases were extracted from the trauma registry of the French department of Rhone from 1996 to 2013...
June 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28253685/determination-of-acoustic-waveguide-invariant-using-ships-as-sources-of-opportunity-in-a-shallow-water-marine-environment
#8
Christopher M A Verlinden, J Sarkar, B D Cornuelle, W A Kuperman
The waveguide invariant (WGI) is a property that can be used to localize acoustic radiators and extract information about the environment. Here the WGI is determined using ships as sources of opportunity, tracked using the Automatic Identification System (AIS). The relationship between range, acoustic intensity, and frequency for a ship in a known position is used to determine the WGI parameter β. These β values are interpolated and a map of β is generated. The method is demonstrated using data collected in a field experiment on a single hydrophone in a shallow water environment off the coast of Southern California...
February 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28253544/stroke-in-right-dorsal-anterior-insular-cortex-is-related-to-myocardial-injury
#9
Thomas Krause, Kathrin Werner, Jochen B Fiebach, Kersten Villringer, Sophie K Piper, Karl Georg Haeusler, Matthias Endres, Jan F Scheitz, Christian H Nolte
OBJECTIVE: Elevated levels of cardiac troponin, and especially their relative changes over time, indicate acute myocardial injury. They are also frequently observed after acute ischemic stroke (AIS), indicating poor functional outcome and increased mortality. However, recent evidence showed that, in most AIS patients, myocardial injury is not caused by coronary ischemia. Instead, stroke lesion location has been suggested to precipitate myocardial injury. METHODS: Voxel-based lesion-symptom mapping (VLSM) was used in 299 patients who had a magnetic resonance imaging-confirmed acute ischemic stroke within the anterior circulation and a high-sensitivity cardiac troponin T (hs-cTnT) acquired on the day of admission...
April 2017: Annals of Neurology
https://www.readbyqxmd.com/read/27931227/epigenetics-of-amphetamine-induced-sensitization-hdac5-expression-and-microrna-in-neural-remodeling
#10
Philip K Liu, Christina H Liu
BACKGROUND: Histone deacetylase (HDAC) activities modify chromatin structure and play a role in learning and memory during developmental processes. Studies of adult mice suggest HDACs are involved in neural network remodeling in brain repair, but its function in drug addiction is less understood. We aimed to examine in vivo HDAC5 expression in a preclinical model of amphetamine-induced sensitization (AIS) of behavior. We generated specific contrast agents to measure HDAC5 levels by in vivo molecular contrast-enhanced (MCE) magnetic resonance imaging (MRI) in amphetamine-naïve mice as well as in mice with AIS...
December 8, 2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/27811503/surface-topography-classification-trees-for-assessing-severity-and-monitoring-progression-in-adolescent-idiopathic-scoliosis-ais
#11
Albert Hong, Neha Jaswal, Lindsey Westover, Eric C Parent, Marc Moreau, Douglas Hedden, Samer Adeeb
STUDY DESIGN: Validation Study OBJECTIVE.: To independently validate the diagnostic accuracy of surface topography (ST) classification trees to identify curve severity and progression using a new sample of data in participants with adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: Radiographs for diagnosing and monitoring AIS involve harmful radiation exposure repeated at successive clinical visits. Classification trees using a novel ST technique have been proposed to determine curve severity and progression non-invasively which could be used to monitor scoliosis...
November 2, 2016: Spine
https://www.readbyqxmd.com/read/27802777/prognostic-factor-analysis-after-surgical-decompression-and-stabilization-for-cervical-spinal-cord-injury
#12
Jin Hoon Park, Jeoung Hee Kim, Sung Woo Roh, Seung Chul Rhim, Sang Ryong Jeon
INTRODUCTION: Several studies have demonstrated the role of decompression surgery in preventing secondary injury and improving the neurological outcome after spinal cord injury (SCI). We retrospectively analyzed the prognostic factors affecting the outcomes of decompression surgery in patients with SCI. METHODS: We performed one-level decompression and fusion surgery on 73 patients with cervical SCI. We classified all patients based on their interval to decompression, sex, age, surgical level, presence of high signal intensity, American Spinal Injury Association Impairment scale (AIS) before surgery, blood pressure at admission, the amount of cord compression, surgical time, estimated blood loss during surgery, and steroid use...
April 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/27653427/effects-of-subclinical-mycobacterium-avium-ssp-paratuberculosis-infection-on-some-physiological-parameters-health-status-and-production-in-dairy-cows
#13
Viktor Jurkovich, Barbara Bognár, Krisztián Balogh, Mária Kovács-Weber, Kinga Fornyos, Rubina Tünde Szabó, Péter Kovács, László Könyves, Miklós Mézes
Milk yield, milk ingredients, health and other, production-related parameters of subclinically infected, Mycobacterium avium ssp. paratuberculosis (MAP-) shedding (positive faecal PCR, n = 20) and non-shedding (negative faecal PCR, n = 10) dairy cows were compared in the period from 10 days prepartum to 120 days postpartum. Body condition, rumen fill and faeces scores were lower in the MAP-shedding cows. There was no significant difference in plasma or urine metabolic parameters between the groups. Milk yield and lactose content tended to be lower (P = 0...
September 2016: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/27586094/development-of-an-expert-based-icd-9-cm-and-icd-10-cm-map-to-ais-2005-update-2008
#14
Kathryn L Loftis, Janet P Price, Patrick J Gillich, Kathy J Cookman, Amy L Brammer, Trish St Germain, Jo Barnes, Vickie Graymire, Donna A Nayduch, Christine Read-Allsopp, Katherine Baus, Patsye A Stanley, Maureen Brennan
OBJECTIVE: This article describes how maps were developed from the clinical modifications of the 9th and 10th revisions of the International Classification of Diseases (ICD) to the Abbreviated Injury Scale 2005 Update 2008 (AIS08). The development of the mapping methodology is described, with discussion of the major assumptions used in the process to map ICD codes to AIS severities. There were many intricacies to developing the maps, because the 2 coding systems, ICD and AIS, were developed for different purposes and contain unique classification structures to meet these purposes...
September 2016: Traffic Injury Prevention
https://www.readbyqxmd.com/read/27565460/higher-mean-arterial-pressure-values-correlate-with-neurologic-improvement-in-patients-with-initially-complete-spinal-cord-injuries
#15
Joshua Stephen Catapano, Gregory William John Hawryluk, William Whetstone, Rajiv Saigal, Adam Ferguson, Jason Talbott, Jacqueline Bresnahan, Sanjay Dhall, Jonathan Pan, Michael Beattie, Geoffrey Manley
BACKGROUND: Traumatic spinal cord injury (SCI) guidelines recommend to maintain mean arterial pressures (MAPs) above 85 mm Hg for 7 days following SCI to minimize spinal cord ischemia. Some physicians doubt that patients with initially complete injuries benefit. OBJECTIVE: To assess the relationship between MAP augmentation and neurologic improvement in SCI patients stratified by initial American Spinal Injury Association Impairment Scale (AIS) score. METHODS: High-frequency MAP values of acute SCI patients admitted over a 6-year period were recorded, and values were correlated with degree of neurologic recovery in an analysis stratified by postresuscitation AIS score...
December 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27452526/tau-mediates-microtubule-bundle-architectures-mimicking-fascicles-of-microtubules-found-in-the-axon-initial-segment
#16
Peter J Chung, Chaeyeon Song, Joanna Deek, Herbert P Miller, Youli Li, Myung Chul Choi, Leslie Wilson, Stuart C Feinstein, Cyrus R Safinya
Tau, an intrinsically disordered protein confined to neuronal axons, binds to and regulates microtubule dynamics. Although there have been observations of string-like microtubule fascicles in the axon initial segment (AIS) and hexagonal bundles in neurite-like processes in non-neuronal cells overexpressing Tau, cell-free reconstitutions have not replicated either geometry. Here we map out the energy landscape of Tau-mediated, GTP-dependent 'active' microtubule bundles at 37 °C, as revealed by synchrotron SAXS and TEM...
2016: Nature Communications
https://www.readbyqxmd.com/read/27367425/improving-fishing-pattern-detection-from-satellite-ais-using-data-mining-and-machine-learning
#17
Erico N de Souza, Kristina Boerder, Stan Matwin, Boris Worm
A key challenge in contemporary ecology and conservation is the accurate tracking of the spatial distribution of various human impacts, such as fishing. While coastal fisheries in national waters are closely monitored in some countries, existing maps of fishing effort elsewhere are fraught with uncertainty, especially in remote areas and the High Seas. Better understanding of the behavior of the global fishing fleets is required in order to prioritize and enforce fisheries management and conservation measures worldwide...
2016: PloS One
https://www.readbyqxmd.com/read/27358687/does-computed-tomography-permeability-predict-hemorrhagic-transformation-after-ischemic-stroke
#18
Peggy Yen, Allison Cobb, Jai Jai Shiva Shankar
AIM: To use perfusion-derived permeability-surface area product maps to predict hemorrhagic transformation following thrombolytic treatment for acute ischemic stroke. METHODS: We retrospectively analyzed our prospectively kept acute stroke database over five consecutive months for patients with symptoms of acute ischemic stroke (AIS) who had computed tomography (CT) perfusion (CTP) done at arrival. Patients included in the analyses also had to have a follow-up CT...
June 28, 2016: World Journal of Radiology
https://www.readbyqxmd.com/read/27271117/the-differential-effects-of-norepinephrine-and-dopamine-on-cerebrospinal-fluid-pressure-and-spinal-cord-perfusion-pressure-after-acute-human-spinal-cord-injury
#19
COMPARATIVE STUDY
F Altaf, D E Griesdale, L Belanger, L Ritchie, J Markez, T Ailon, M C Boyd, S Paquette, C G Fisher, J Street, M F Dvorak, B K Kwon
STUDY DESIGN: Prospective vasopressor cross-over interventional studyObjectives:To examine how two vasopressors used in acute traumatic spinal cord injury (SCI) affect intrathecal cerebrospinal fluid pressure and the corresponding spinal cord perfusion pressure (SCPP). SETTING: Vancouver, British Columbia, Canada. METHODS: Acute SCI patients over the age of 17 with cervical or thoracic ASIA Impairment Scale (AIS). A, B or C injuries were enrolled in this study...
January 2017: Spinal Cord
https://www.readbyqxmd.com/read/27234817/near-infrared-spectroscopic-mapping-of-functional-properties-of-equine-articular-cartilage
#20
Jaakko K Sarin, Michael Amissah, Harold Brommer, David Argüelles, Juha Töyräs, Isaac O Afara
Mechanical properties of articular cartilage are vital for normal joint function, which can be severely compromised by injuries. Quantitative characterization of cartilage injuries, and evaluation of cartilage stiffness and thickness by means of conventional arthroscopy is poorly reproducible or impossible. In this study, we demonstrate the potential of near infrared (NIR) spectroscopy for predicting and mapping the functional properties of equine articular cartilage at and around lesion sites. Lesion and non-lesion areas of interests (AI, N = 44) of equine joints (N = 5) were divided into grids and NIR spectra were acquired from all grid points (N = 869)...
November 2016: Annals of Biomedical Engineering
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