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https://www.readbyqxmd.com/read/27931227/epigenetics-of-amphetamine-induced-sensitization-hdac5-expression-and-microrna-in-neural-remodeling
#1
Philip K Liu, Christina H Liu
BACKGROUND: Histone deacetylase (HDAC) activities modify chromatin structure and play a role in learning and memory during developmental processes. Studies of adult mice suggest HDACs are involved in neural network remodeling in brain repair, but its function in drug addiction is less understood. We aimed to examine in vivo HDAC5 expression in a preclinical model of amphetamine-induced sensitization (AIS) of behavior. We generated specific contrast agents to measure HDAC5 levels by in vivo molecular contrast-enhanced (MCE) magnetic resonance imaging (MRI) in amphetamine-naïve mice as well as in mice with AIS...
December 8, 2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/27811503/surface-topography-classification-trees-for-assessing-severity-and-monitoring-progression-in-adolescent-idiopathic-scoliosis-ais
#2
Albert Hong, Neha Jaswal, Lindsey Westover, Eric C Parent, Marc Moreau, Douglas Hedden, Samer Adeeb
STUDY DESIGN: Validation Study OBJECTIVE.: To independently validate the diagnostic accuracy of surface topography (ST) classification trees to identify curve severity and progression using a new sample of data in participants with adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: Radiographs for diagnosing and monitoring AIS involve harmful radiation exposure repeated at successive clinical visits. Classification trees using a novel ST technique have been proposed to determine curve severity and progression non-invasively which could be used to monitor scoliosis...
November 2, 2016: Spine
https://www.readbyqxmd.com/read/27802777/prognostic-factor-analysis-after-surgical-decompression-and-stabilization-for-cervical-spinal-cord-injury
#3
Jin Hoon Park, Jeoung Hee Kim, Sung Woo Roh, Seung Chul Rhim, Sang Ryong Jeon
INTRODUCTION: Several studies have demonstrated the role of decompression surgery in preventing secondary injury and improving the neurological outcome after spinal cord injury (SCI). We retrospectively analyzed the prognostic factors affecting the outcomes of decompression surgery in patients with SCI. METHODS: We performed one-level decompression and fusion surgery on 73 patients with cervical SCI. We classified all patients based on their interval to decompression, sex, age, surgical level, presence of high signal intensity, American Spinal Injury Association Impairment scale (AIS) before surgery, blood pressure at admission, the amount of cord compression, surgical time, estimated blood loss during surgery, and steroid use...
November 2, 2016: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/27653427/effects-of-subclinical-mycobacterium-avium-ssp-paratuberculosis-infection-on-some-physiological-parameters-health-status-and-production-in-dairy-cows
#4
Viktor Jurkovich, Barbara Bognár, Krisztián Balogh, Mária Kovács-Weber, Kinga Fornyos, Rubina Tünde Szabó, Péter Kovács, László Könyves, Miklós Mézes
Milk yield, milk ingredients, health and other, production-related parameters of subclinically infected, Mycobacterium avium ssp. paratuberculosis (MAP-) shedding (positive faecal PCR, n = 20) and non-shedding (negative faecal PCR, n = 10) dairy cows were compared in the period from 10 days prepartum to 120 days postpartum. Body condition, rumen fill and faeces scores were lower in the MAP-shedding cows. There was no significant difference in plasma or urine metabolic parameters between the groups. Milk yield and lactose content tended to be lower (P = 0...
September 2016: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/27586094/development-of-an-expert-based-icd-9-cm-and-icd-10-cm-map-to-ais-2005-update-2008
#5
Kathryn L Loftis, Janet P Price, Patrick J Gillich, Kathy J Cookman, Amy L Brammer, Trish St Germain, Jo Barnes, Vickie Graymire, Donna A Nayduch, Christine Read-Allsopp, Katherine Baus, Patsye A Stanley, Maureen Brennan
OBJECTIVE: This article describes how maps were developed from the clinical modifications of the 9th and 10th revisions of the International Classification of Diseases (ICD) to the Abbreviated Injury Scale 2005 Update 2008 (AIS08). The development of the mapping methodology is described, with discussion of the major assumptions used in the process to map ICD codes to AIS severities. There were many intricacies to developing the maps, because the 2 coding systems, ICD and AIS, were developed for different purposes and contain unique classification structures to meet these purposes...
September 2016: Traffic Injury Prevention
https://www.readbyqxmd.com/read/27565460/higher-mean-arterial-pressure-values-correlate-with-neurologic-improvement-in-patients-with-initially-complete-spinal-cord-injuries
#6
Joshua Stephen Catapano, Gregory William John Hawryluk, William Whetstone, Rajiv Saigal, Adam Ferguson, Jason Talbott, Jacqueline Bresnahan, Sanjay Dhall, Jonathan Pan, Michael Beattie, Geoffrey Manley
BACKGROUND: Traumatic spinal cord injury (SCI) guidelines recommend to maintain mean arterial pressures (MAPs) above 85 mm Hg for 7 days following SCI to minimize spinal cord ischemia. Some physicians doubt that patients with initially complete injuries benefit. OBJECTIVE: To assess the relationship between MAP augmentation and neurologic improvement in SCI patients stratified by initial American Spinal Injury Association Impairment Scale (AIS) score. METHODS: High-frequency MAP values of acute SCI patients admitted over a 6-year period were recorded, and values were correlated with degree of neurologic recovery in an analysis stratified by postresuscitation AIS score...
December 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27452526/tau-mediates-microtubule-bundle-architectures-mimicking-fascicles-of-microtubules-found-in-the-axon-initial-segment
#7
Peter J Chung, Chaeyeon Song, Joanna Deek, Herbert P Miller, Youli Li, Myung Chul Choi, Leslie Wilson, Stuart C Feinstein, Cyrus R Safinya
Tau, an intrinsically disordered protein confined to neuronal axons, binds to and regulates microtubule dynamics. Although there have been observations of string-like microtubule fascicles in the axon initial segment (AIS) and hexagonal bundles in neurite-like processes in non-neuronal cells overexpressing Tau, cell-free reconstitutions have not replicated either geometry. Here we map out the energy landscape of Tau-mediated, GTP-dependent 'active' microtubule bundles at 37 °C, as revealed by synchrotron SAXS and TEM...
2016: Nature Communications
https://www.readbyqxmd.com/read/27367425/improving-fishing-pattern-detection-from-satellite-ais-using-data-mining-and-machine-learning
#8
Erico N de Souza, Kristina Boerder, Stan Matwin, Boris Worm
A key challenge in contemporary ecology and conservation is the accurate tracking of the spatial distribution of various human impacts, such as fishing. While coastal fisheries in national waters are closely monitored in some countries, existing maps of fishing effort elsewhere are fraught with uncertainty, especially in remote areas and the High Seas. Better understanding of the behavior of the global fishing fleets is required in order to prioritize and enforce fisheries management and conservation measures worldwide...
2016: PloS One
https://www.readbyqxmd.com/read/27358687/does-computed-tomography-permeability-predict-hemorrhagic-transformation-after-ischemic-stroke
#9
Peggy Yen, Allison Cobb, Jai Jai Shiva Shankar
AIM: To use perfusion-derived permeability-surface area product maps to predict hemorrhagic transformation following thrombolytic treatment for acute ischemic stroke. METHODS: We retrospectively analyzed our prospectively kept acute stroke database over five consecutive months for patients with symptoms of acute ischemic stroke (AIS) who had computed tomography (CT) perfusion (CTP) done at arrival. Patients included in the analyses also had to have a follow-up CT...
June 28, 2016: World Journal of Radiology
https://www.readbyqxmd.com/read/27271117/the-differential-effects-of-norepinephrine-and-dopamine-on-cerebrospinal-fluid-pressure-and-spinal-cord-perfusion-pressure-after-acute-human-spinal-cord-injury
#10
F Altaf, D E Griesdale, L Belanger, L Ritchie, J Markez, T Ailon, M C Boyd, S Paquette, C G Fisher, J Street, M F Dvorak, B K Kwon
STUDY DESIGN: Prospective vasopressor cross-over interventional studyObjectives:To examine how two vasopressors used in acute traumatic spinal cord injury (SCI) affect intrathecal cerebrospinal fluid pressure and the corresponding spinal cord perfusion pressure (SCPP). SETTING: Vancouver, British Columbia, Canada. METHODS: Acute SCI patients over the age of 17 with cervical or thoracic ASIA Impairment Scale (AIS). A, B or C injuries were enrolled in this study...
June 7, 2016: Spinal Cord
https://www.readbyqxmd.com/read/27234817/near-infrared-spectroscopic-mapping-of-functional-properties-of-equine-articular-cartilage
#11
Jaakko K Sarin, Michael Amissah, Harold Brommer, David Argüelles, Juha Töyräs, Isaac O Afara
Mechanical properties of articular cartilage are vital for normal joint function, which can be severely compromised by injuries. Quantitative characterization of cartilage injuries, and evaluation of cartilage stiffness and thickness by means of conventional arthroscopy is poorly reproducible or impossible. In this study, we demonstrate the potential of near infrared (NIR) spectroscopy for predicting and mapping the functional properties of equine articular cartilage at and around lesion sites. Lesion and non-lesion areas of interests (AI, N = 44) of equine joints (N = 5) were divided into grids and NIR spectra were acquired from all grid points (N = 869)...
May 27, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27137901/mapping-the-road-to-recovery-shorter-stays-and-satisfied-patients-in-posterior-spinal-fusion
#12
Rameshwar R Rao, MaryAnn Hayes, Cathy Lewis, Robert N Hensinger, Frances A Farley, Ying Li, Michelle S Caird
BACKGROUND: Adolescent idiopathic scoliosis (AIS) patients undergoing posterior spinal fusion (PSF) experience variations in their hospital care, which may lead to differences in objective and patient-reported outcomes. The purpose of this study was to demonstrate that using plan of care-educating families preoperatively and standardizing some aspects of care-would decrease time to mobility and time to discharge while maintaining pain control and patient satisfaction. METHODS: Chart review was conducted in 3 groups-preprotocol (December 2008 to December 2009, n=51), first protocol (December 2, 2009 to July 24, 2013, n=100), and second protocol (July 25, 2013 to June 1, 2014, n=39)-to track pain scores (0 to 10), time to regular diet, Foley catheter removal, epidural catheter removal, mobility, and discharge...
May 2, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27051411/lower-intraprocedural-systolic-blood-pressure-predicts-good-outcome-in-patients-undergoing-endovascular-therapy-for-acute-ischemic-stroke
#13
Seby John, Walaa Hazaa, Ken Uchino, Gabor Toth, Mark Bain, Umera Thebo, Muhammad S Hussain
BACKGROUND: It is unknown if intraprocedural blood pressure (BP) influences clinical outcomes and what BP parameter best predicts outcomes in acute ischemic stroke (AIS) patients who undergo intra-arterial therapy (IAT) for emergent large vessel occlusion. METHODS: We retrospectively reviewed 147 patients who underwent IAT for anterior circulation AIS from January 2008 to December 2012 at our institution. Baseline demographics, stroke treatment variables, and detailed intraprocedural hemodynamic variables were collected...
March 2016: Interventional Neurology
https://www.readbyqxmd.com/read/26930290/iterative-reconstruction-improves-both-objective-and-subjective-image-quality-in-acute-stroke-ctp
#14
Fabian Flottmann, Jan Kabath, Till Illies, Tanja Schneider, Jan-Hendrik Buhk, Jens Fiehler, André Kemmling
PURPOSE: Computed tomography perfusion (CTP) imaging in acute ischemic stroke (AIS) suffers from measurement errors due to image noise. The purpose of this study was to investigate if iterative reconstruction (IR) algorithms can be used to improve the diagnostic value of standard-dose CTP in AIS. METHODS: Twenty-three patients with AIS underwent CTP with standardized protocol and dose. Raw data were reconstructed with filtered back projection (FBP) and IR with intensity levels 3, 4, 5...
2016: PloS One
https://www.readbyqxmd.com/read/26867026/mri-assessment-of-ischemic-lesion-evolution-within-white-and-gray-matter
#15
Lise-Prune Berner, Tae-Hee Cho, Julie Haesebaert, Julien Bouvier, Marlène Wiart, Niels Hjort, Irene Klærke Mikkelsen, Laurent Derex, Götz Thomalla, Salvador Pedraza, Leif Østergaard, Jean-Claude Baron, Norbert Nighoghossian, Yves Berthezène
BACKGROUND: In acute ischemic stroke (AIS), gray matter (GM) and white matter (WM) have different vulnerabilities to ischemia. Thus, we compared the evolution of ischemic lesions within WM and GM using MRI. METHODS: From a European multicenter prospective database (I-KNOW), available T1-weighted images were identified for 50 patients presenting with an anterior AIS and a perfusion weighted imaging (PWI)/diffusion weighted imaging (DWI) mismatch ratio of 1.2 or more...
2016: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/26824672/cerebral-blood-volume-aspects-is-the-best-predictor-of-clinical-outcome-in-acute-ischemic-stroke-a-retrospective-combined-semi-quantitative-and-quantitative-assessment
#16
Marina Padroni, Andrea Bernardoni, Carmine Tamborino, Gloria Roversi, Massimo Borrelli, Andrea Saletti, Alessandro De Vito, Cristiano Azzini, Luca Borgatti, Onofrio Marcello, Christopher d'Esterre, Stefano Ceruti, Ilaria Casetta, Ting-Yim Lee, Enrico Fainardi
INTRODUCTION: The capability of CT perfusion (CTP) Alberta Stroke Program Early CT Score (ASPECTS) to predict outcome and identify ischemia severity in acute ischemic stroke (AIS) patients is still questioned. METHODS: 62 patients with AIS were imaged within 8 hours of symptom onset by non-contrast CT, CT angiography and CTP scans at admission and 24 hours. CTP ASPECTS was calculated on the affected hemisphere using cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) maps by subtracting 1 point for any abnormalities visually detected or measured within multiple cortical circular regions of interest according to previously established thresholds...
2016: PloS One
https://www.readbyqxmd.com/read/26822044/-signifiance-of-brush-sign-on-susceptibility-weighted-imaging-predicts-hemorrhagic-transformation-after-intravenous-thrombolysis-in-patients-with-acute-ischemic-stroke
#17
Chao Xu, Zhi-cai Chen, Huan Tang, Meng-jun Xu, Sheng Zhang, Jian-zhong Sun, Min Lou
OBJECTIVE: To assess brush sign (BS) on susceptibility-weighted imaging (SWI) in prediction of hemorrhagic transformation (HT) in patients with acute ischemic stroke (AIS) after intravenous thrombolysis(IVT). METHODS: Patients with acute cerebral ischemic stroke, who had major cerebral artery occlusion (internal carotid artery, middle cerebral artery M1 and M2), treated with intravenous recombinant tissue plasminogen activator (rt-PA) from August 2009 to October 2014 in the Second Affiliated Hospital, Zhejiang University School of Medicine, were enrolled in the study...
November 2015: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/26801947/ct-perfusion-and-angiographic-assessment-of-pial-collateral-reperfusion-in-acute-ischemic-stroke-the-capri-study
#18
Arturo Consoli, Tommy Andersson, Ake Holmberg, Luca Verganti, Andrea Saletti, Stefano Vallone, Andrea Zini, Alfonso Cerase, Daniele Romano, Sandra Bracco, Svetlana Lorenzano, Enrico Fainardi, Salvatore Mangiafico
BACKGROUND: The purpose of this study was to evaluate the correlation between a novel angiographic score for collaterals and CT perfusion (CTP) parameters in patients undergoing endovascular treatment for acute ischemic stroke (AIS). METHODS: 103 patients (mean age 66.7±12.7; 48.5% men) with AIS in the anterior circulation territory, imaged with non-contrast CT, CT angiography, and CTP, admitted within 8 h from symptom onset and treated with any endovascular approach, were retrospectively included in the study...
January 22, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/26786641/ct-perfusion-in-acute-stroke-predicts-final-infarct-volume-inter-observer-study
#19
Jai Jai Shiva Shankar, Gavin Langlands, Steve Doucette, Stephen Phillips
BACKGROUND: Computed tomography perfusion (CTP) is increasingly being used in the setting of acute ischemic stroke (AIS). The aim of the current study was to compare the prognostic utility of, and inter-observer variation between, baseline appearances on non-contrast CT (using Alberta Stroke Program Early CT score(ASPECTS)) and on CTP for predicting final infarct volume. We also assessed impact of training on interpretation of these images. METHODS: Retrospectively, plain head computed tomography (CT) and CTP images at presentation and CT or diffusion imaging on follow up of patients with AIS were analyzed...
January 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/26783311/quality-adjusted-life-year-gains-associated-with-administration-of-recombinant-tissue-type-plasminogen-activator-for-treatment-of-acute-ischemic-stroke-1998-2011
#20
Deborah P Lubeck, Mark D Danese, Jennifer Duryea, Marc Halperin, Darren Tayama, Elaine Yu, Deepa Lalla, James C Grotta
BACKGROUND: Intravenous recombinant tissue-type plasminogen activator (r-tPA) is an approved treatment for select patients with acute ischemic stroke (AIS). Data indicate r-tPA improves functional outcome three months after AIS compared with placebo. This study models the increase in quality adjusted life years (QALYs) associated with r-tPA compared with similar patients not treated with r-tPA. METHODS: Hospital discharge data for AIS and r-tPA were obtained from the Nationwide Inpatient Sample from 1998 to 2011...
February 2016: International Journal of Stroke: Official Journal of the International Stroke Society
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