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https://www.readbyqxmd.com/read/29424203/clinicopathological-significance-of-chemokine-receptor-cxcr4-expression-in-papillary-thyroid-carcinoma-a-meta-analysis
#1
Zhaoshu Wu, Yue Cao, Xiaoyan Jiang, Min Li, Gang Wang, Yue Yang, Kai Lu
INTRODUCTION: Emerging evidence indicates that C-X-C chemokine receptor type 4(CXCR 4) is a candidate oncogene in several types of human tumors including papillary thyroid carcinoma (PTC). To investigate its expression impact on clinicopathological features, a meta-analysis was performed. EVIDENCE ACQUISITION: A comprehensive search in the PubMed, Embase and The Cochrane Library (up to March 14, 2017) was performed for relevant studies using multiple search strategies...
February 8, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29401697/prediction-of-disordered-regions-and-their-roles-in-the-anti-pathogenic-and-immunomodulatory-functions-of-butyrophilins
#2
Elrashdy M Redwan, Ahmed M Al-Hejin, Hussein A Almehdar, Abdelrahman M Elsaway, Vladimir N Uversky
Butyrophilins (BTNs) are a group of the moonlighting proteins, some members of which are secreted in milk. They constitute a large family of structurally similar type 1 transmembrane proteins from the immunoglobulin superfamily. Although the founding member of this family is related to lactation, participating in the secretion, formation and stabilization of milk fat globules, it may also have a cell surface receptor function. Generally, the BTN family members are known to modulate co-stimulatory responses, T cell selection, differentiation, and cell fate determination...
February 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29369457/the-economic-burden-of-epilepsy-in-bhutan
#3
Leah Wibecan, Günther Fink, Lhab Tshering, Veronica Bruno, Bryan Patenaude, Damber K Nirola, Chencho Dorji, Ugyen Dema, Dillram Pokhrel, Farrah J Mateen
OBJECTIVE: To assess the economic impact of epilepsy in Bhutan, a lower-middle-income country with a universal health care system, but with limited access to neurological care. METHODS: A cross-sectional survey was conducted of patients with epilepsy at the Jigme Dorji Wangchuk National Referral Hospital from January to August 2016. Data were collected on clinical features, cost of care, impact of epilepsy on school or work and household economic status of participants and matched comparisons (a sibling or neighbour from a household without epilepsy)...
April 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29339503/heteromeric-interactions-regulate-butyrophilin-btn-and-btn-like-molecules-governing-%C3%AE-%C3%AE-t-cell-biology
#4
Pierre Vantourout, Adam Laing, Martin J Woodward, Iva Zlatareva, Luis Apolonia, Andrew W Jones, Ambrosius P Snijders, Michael H Malim, Adrian C Hayday
The long-held view that gamma delta (γδ) T cells in mice and humans are fundamentally dissimilar, as are γδ cells in blood and peripheral tissues, has been challenged by emerging evidence of the cells' regulation by butyrophilin (BTN) and butyrophilin-like (BTNL) molecules. Thus, murine Btnl1 and the related gene, Skint1 , mediate T cell receptor (TCR)-dependent selection of murine intraepithelial γδ T cell repertoires in gut and skin, respectively; BTNL3 and BTNL8 are TCR-dependent regulators of human gut γδ cells; and BTN3A1 is essential for TCR-dependent activation of human peripheral blood Vγ9Vδ2+ T cells...
January 30, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29228629/type-2-diabetes-mellitus-is-more-prevalent-among-patients-with-thyroid-carcinoma-and-influences-overall-survival-a-propensity-score-matching-analysis
#5
Tao Jiang, Guoliang Qiao, Xiao Zheng, Zhen Wen, Dongxue Zhang
The relationship between Type 2 Diabetes Mellitus(T2DM) and cancer risk has been investigated for more than a decade. Many types of cancer were confirmed to be related with T2DM. The aim of this study is to identify the relationship between T2DM and the prevalence and long-term survivals of Thyroid Carcinoma(TC) using propensity score matching. In present study, 1658 thyroid nodule patients who were diagnosis in Beijing Shijitan hospital were divided into two groups: the TC group (N = 455, 27.4%), and the benign thyroid nodule(BTN) group (N = 1203, 73...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29164992/factors-associated-with-recurrence-of-btn-after-ablation
#6
Bei Wang, Zhi-Yu Han, Jie Yu, Ping Liang
No abstract text is available yet for this article.
December 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29107049/environmentally-responsive-dual-targeting-nanoparticles-improving-drug-accumulation-in-cancer-cells-as-a-way-of-preventing-anticancer-drug-efflux
#7
Cenk Daglioglu
Drug targeting and stimuli-responsive drug release are 2 active areas of cancer research and hold tremendous potential in the management of cancer drug resistance. In this study, I addressed this issue and focused on the synthesis and characterization of pH-responsive Fe3 O4 @SiO2 (FITC)-BTN/folic acid/DOX multifunctional nanoparticles aiming to increase drug accumulation in malignancies with both dual active targeting and endosomal drug release properties. Dye-doped silica magnetic-fluorescent composite was constructed by a simple coprecipitation of Fe+2 /Fe+3 salts followed by sol-gel formation and dual-targeting function was obtained by conjugating folate and biotin moieties on the silica surface of nanoparticles via an esterification reaction...
March 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28719067/one-pot-synthesis-of-cu-nanocluster-decorated-brookite-tio-2-quasi-nanocubes-for-enhanced-activity-and-selectivity-of-co-2-photoreduction-to-ch-4
#8
Jingpeng Jin, Jiang Luo, Ling Zan, Tianyou Peng
A new kind of metallic Cu-loaded brookite TiO2 composite, in which Cu nanoclusters with a small size of 1-3 nm are decorated on brookite TiO2 quasi nanocube (BTN) surfaces (hereafter referred to as Cu-BTN), is synthesized via a one-pot hydrothermal process and then used as photocatalyst for CO2 reduction. It was found that the decoration of Cu nanoclusters on BTN surfaces can improve the activity and selectivity of CO2 photoreduction to CH4 , and 1.5 % Cu-BTN gives a maximum overall photocatalytic activity (150...
November 17, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28649364/immunosurveillance-by-human-%C3%AE-%C3%AE-t-lymphocytes-the-emerging-role-of-butyrophilins
#9
REVIEW
Dieter Kabelitz, Marcus Lettau, Ottmar Janssen
In contrast to conventional T lymphocytes, which carry an αβ T-cell receptor and recognize antigens as peptides presented by major histocompatibility complex class I or class II molecules, human γδ T cells recognize different metabolites such as non-peptidic pyrophosphate molecules that are secreted by microbes or overproduced by tumor cells. Hence, γδ T cells play a role in immunosurveillance of infection and cellular transformation. Until recently, it has been unknown how the γδ T-cell receptor senses such pyrophosphates in the absence of known antigen-presenting molecules...
2017: F1000Research
https://www.readbyqxmd.com/read/28599426/dynamic-monitoring-of-circulating-micrornas-as-a-predictive-biomarker-for-the-diagnosis-and-recurrence-of-papillary-thyroid-carcinoma
#10
Yanqing Zhang, Desheng Xu, Jiaqi Pan, Zhengkai Yang, Meijun Chen, Jun Han, Sijia Zhang, Lulu Sun, Hong Qiao
Circulating microRNAs (miRNAs/miRs) are considered to be potential biomarkers for numerous types of cancer. However, previous investigations into the expression of miRNAs in the serum of patients with papillary thyroid carcinoma (PTC) to predict diagnosis, prognosis and recurrence have reported conflicting results, and the role of miRNAs remains unclear. The present study dynamically assessed the circulating miRNA profile in patients with PTC and determined whether miRNAs in the serum could be used as biomarkers for the diagnosis, prognosis and recurrence of PTC...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28528134/enhancing-tumor-cell-response-to-multidrug-resistance-with-ph-sensitive-quercetin-and-doxorubicin-conjugated-multifunctional-nanoparticles
#11
Cenk Daglioglu
Classical chemotherapy uses chemotherapeutic agents as a mainstay of anticancer treatment. However, the development of multidrug resistance to chemotherapy limits the effectiveness of current cancer treatment. Nanosized bioconjugates combining a chemotherapeutic agent with a pharmacological approach may improve the curative effect of chemotherapeutic agents. Herein I addressed this issue by describing the synthesis, and testing of, pH-responsive Fe3O4@SiO2(FITC)-BTN/QUR/DOX multifunctional nanoparticles. The particles were designed to modulate resistance-mediating factors and to potentiate the efficacy of DOX against chemoresistance...
May 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28461569/the-juxtamembrane-domain-of-butyrophilin-btn3a1-controls-phosphoantigen-mediated-activation-of-human-v%C3%AE-9v%C3%AE-2-t-cells
#12
Cassie-Marie Peigné, Alexandra Léger, Marie-Claude Gesnel, Fabienne Konczak, Daniel Olive, Marc Bonneville, Richard Breathnach, Emmanuel Scotet
Vγ9Vδ2 T lymphocytes are the major human peripheral γδ T cell subset, with broad reactivity against stressed human cells, including tumor cells. Vγ9Vδ2 T cells are specifically activated by small phosphorylated metabolites called phosphoantigens (PAg). Stress-induced changes in target cell PAg levels are specifically detected by butyrophilin (BTN)3A1, using its intracellular B30.2 domain. This leads to the activation of Vγ9Vδ2 T cells. In this study, we show that changes in the juxtamembrane domain of BTN3A1, but not its transmembrane domain, induce a markedly enhanced or reduced γδ T cell reactivity...
June 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28226000/efficacy-and-safety-of-a-single-radiofrequency-ablation-of-solid-benign-non-functioning-thyroid-nodules
#13
Roberto Cesareo, Andrea Palermo, Valerio Pasqualini, Carla Simeoni, Alessandro Casini, Giuseppe Pelle, Silvia Manfrini, Giuseppe Campagna, Roberto Cianni
Objective: The objective of our study is to evaluate the clinical outcomes and safety of radiofrequency thermal ablation (RFA) for benign thyroid nodules (BTNs) over a 1-year follow-up. Subjects and methods: This is a monocentric retrospective study. Forty-eight patients with solid, non-functioning BTNs were treated by RFA using a 17G internally cooled electrode. We categorized thyroid nodules as small (≤ 12 mL), medium (12 to 30 mL), or large (over 30 mL). BTNs volume reduction, thyroid function, cosmetic and compressive score changes and side effect evaluation at 6 and 12 months were evaluated...
March 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28194984/signal-enhancement-with-stacked-magnets-for-high-resolution-radio-frequency-glow-discharge-mass-spectrometry
#14
Juan Wei, Jiangli Dong, Shangjun Zhuo, Rong Qian, Yuanxing Fang, Qiao Chen, Ekbal Patel
A method for signal enhancement utilizing stacked magnets was introduced into high-resolution radio frequency glow discharge-mass spectrometry (rf-GD-MS) for significantly improved analysis of inorganic materials. Compared to the block magnet, the stacked magnets method was able to achieve 50-59% signal enhancement for typical elements in Y2O3, BSO, and BTN samples. The results indicated that signal was enhanced as the increase of discharge pressure from 1.3 to 8.0 mPa, the increase of rf-power from 10 to 50 W with a frequency of 13...
January 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28057464/graphene-quantum-dots-for-cancer-targeted-drug-delivery
#15
Daniela Iannazzo, Alessandro Pistone, Marina Salamò, Signorino Galvagno, Roberto Romeo, Salvatore V Giofré, Caterina Branca, Giuseppa Visalli, Angela Di Pietro
A biocompatible and cell traceable drug delivery system Graphene Quantum Dots (GQD) based, for the targeted delivery of the DNA intercalating drug doxorubicin (DOX) to cancer cells, is here reported. Highly dispersible and water soluble GQD, synthesized by acidic oxidation and exfoliation of multi-walled carbon nanotubes (MWCNT), were covalently linked to the tumor targeting module biotin (BTN), able to efficiently recognize biotin receptors over-expressed on cancer cells and loaded with DOX. Biological test performed on A549 cells reported a very low toxicity of the synthesized carrier (GQD and GQD-BTN)...
February 25, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27975148/complications-encountered-in-ultrasonography-guided-radiofrequency-ablation-of-benign-thyroid-nodules-and-recurrent-thyroid-cancers
#16
Cherry Kim, Jeong Hyun Lee, Young Jun Choi, Won Bae Kim, Tae Yon Sung, Jung Hwan Baek
OBJECTIVES: To evaluate the complication rates and describe the possible complications of ultrasonography-guided radiofrequency ablation (RFA) of benign thyroid nodules (BTN) and recurrent thyroid cancers (RTC), and to compare the complication rates between BTN and RTC. METHODS: This retrospective study reviewed 875 patients who underwent RFA for BTN (746 patients; 83.5%) or RTC (129 patients; 14.7%). Medical records were reviewed for all types of complications occurring during and after the RFA procedure...
August 2017: European Radiology
https://www.readbyqxmd.com/read/27957327/altered-expression-of-butyrophilin-btn-and-btn-like-btnl-genes-in-intestinal-inflammation-and-colon-cancer
#17
Cristina Lebrero-Fernández, Ulf Alexander Wenzel, Paulina Akeus, Ying Wang, Hans Strid, Magnus Simrén, Bengt Gustavsson, Lars G Börjesson, Susanna L Cardell, Lena Öhman, Marianne Quiding-Järbrink, Anna Bas-Forsberg
Several Butyrophilin (BTN) and Btn-like (BTNL) molecules control T lymphocyte responses, and are genetically associated with inflammatory disorders and cancer. In this study, we present a comprehensive expression analysis of human and murine BTN and BTNL genes in conditions associated with intestinal inflammation and cancer. Using real-time PCR, expression of human BTN and BTNL genes was analyzed in samples from patients with ulcerative colitis, irritable bowel syndrome, and colon tumors. Expression of murine Btn and Btnl genes was examined in mouse models of spontaneous colitis (Muc2(-/-)) and intestinal tumorigenesis (Apc(Min/+))...
June 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27883069/quality-of-life-and-cost-effectiveness-of-radiofrequency-ablation-versus-open-surgery-for-benign-thyroid-nodules-a-retrospective-cohort-study
#18
Wen-Wen Yue, Xiao-Long Li, Hui-Xiong Xu, Feng Lu, Li-Ping Sun, Le-Hang Guo, Ya-Ping He, Dan Wang, Zhi-Qiang Yin
This study is to compare the health-related quality of life (HRQoL) and cost-effectiveness of radiofrequency ablation (RFA) and open thyroidectomy (OT) for benign thyroid nodules (BTNs) treatment. HRQoL and utility were assessed for 404 BTN patients immediately before treatments (RFA:OT = 137:267) and at 6-month visit. A cost-effectiveness analysis was performed from societal perspective in the China context. Resource use (hospitalization, sick leaves) was collected. We used the net monetary benefit approach and computed cost-effectiveness acceptability curves for RFA and OT...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27801467/preparation-of-brookite-tio2-nanoparticles-with-small-sizes-and-the-improved-photovoltaic-performance-of-brookite-based-dye-sensitized-solar-cells
#19
Jinlei Xu, Shufang Wu, Jingpeng Jin, Tianyou Peng
Brookite TiO2 nanoparticles with small sizes (hereafter denoted as BTP particles) were synthesized through the hydrothermal treatment of TiCl4 solution with Pb(NO3)2 as an additive. The obtained BTP particles have a large specific surface area (∼122.2 m(2) g(-1)) and relatively uniform particle sizes (∼10 nm) with the coexistence of a small quantity of nanorods with a length of ∼100 nm. When used as a photoanode material for dye-sensitized solar cells (DSSCs), the BTP particles show a much higher dye-loading content than the brookite TiO2 quasi nanocubes (denoted as BTN particles) with a mean size of ∼50 nm and a specific surface area of ∼34...
November 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27690048/planar-indium-tin-oxide-heater-for-improved-thermal-distribution-for-metal-oxide-micromachined-gas-sensors
#20
M Cihan Çakır, Deniz Çalışkan, Bayram Bütün, Ekmel Özbay
Metal oxide gas sensors with integrated micro-hotplate structures are widely used in the industry and they are still being investigated and developed. Metal oxide gas sensors have the advantage of being sensitive to a wide range of organic and inorganic volatile compounds, although they lack selectivity. To introduce selectivity, the operating temperature of a single sensor is swept, and the measurements are fed to a discriminating algorithm. The efficiency of those data processing methods strongly depends on temperature uniformity across the active area of the sensor...
September 29, 2016: Sensors
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