Read by QxMD icon Read


Tianyou Peng, Jingpeng Jin, Jiang Luo, Lin Zan
A new kind of metallic Cu-loaded brookite TiO2 composite, in which Cu nanoclusters with small size of 1-3 nm are decorated on brookite TiO2 quasi nanocubes (BTN) surfaces (hereafter referred as Cu-BTN), is synthesized via a one-pot hydrothermal process, and then used as photocatalyst for CO2 reduction. It was found that the decoration of Cu nanoclusters on BTN surfaces can improve the activity and selectivity of CO2 photoreduction to CH4 production, and 1.5% Cu-BTN gives the maximum overall photocatalytic activity (150...
July 18, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Dieter Kabelitz, Marcus Lettau, Ottmar Janssen
In contrast to conventional T lymphocytes, which carry an αβ T-cell receptor and recognize antigens as peptides presented by major histocompatibility complex class I or class II molecules, human γδ T cells recognize different metabolites such as non-peptidic pyrophosphate molecules that are secreted by microbes or overproduced by tumor cells. Hence, γδ T cells play a role in immunosurveillance of infection and cellular transformation. Until recently, it has been unknown how the γδ T-cell receptor senses such pyrophosphates in the absence of known antigen-presenting molecules...
2017: F1000Research
Yanqing Zhang, Desheng Xu, Jiaqi Pan, Zhengkai Yang, Meijun Chen, Jun Han, Sijia Zhang, Lulu Sun, Hong Qiao
Circulating microRNAs (miRNAs/miRs) are considered to be potential biomarkers for numerous types of cancer. However, previous investigations into the expression of miRNAs in the serum of patients with papillary thyroid carcinoma (PTC) to predict diagnosis, prognosis and recurrence have reported conflicting results, and the role of miRNAs remains unclear. The present study dynamically assessed the circulating miRNA profile in patients with PTC and determined whether miRNAs in the serum could be used as biomarkers for the diagnosis, prognosis and recurrence of PTC...
June 2017: Oncology Letters
Cenk Daglioglu
Classical chemotherapy uses chemotherapeutic agents as a mainstay of anticancer treatment. However, the development of multidrug resistance to chemotherapy limits the effectiveness of current cancer treatment. Nanosized bioconjugates combining a chemotherapeutic agent with a pharmacological approach may improve the curative effect of chemotherapeutic agents. Herein I addressed this issue by describing the synthesis, and testing of, pH-responsive Fe3O4@SiO2(FITC)-BTN/QUR/DOX multifunctional nanoparticles. The particles were designed to modulate resistance-mediating factors and to potentiate the efficacy of DOX against chemoresistance...
May 10, 2017: Colloids and Surfaces. B, Biointerfaces
Cassie-Marie Peigné, Alexandra Léger, Marie-Claude Gesnel, Fabienne Konczak, Daniel Olive, Marc Bonneville, Richard Breathnach, Emmanuel Scotet
Vγ9Vδ2 T lymphocytes are the major human peripheral γδ T cell subset, with broad reactivity against stressed human cells, including tumor cells. Vγ9Vδ2 T cells are specifically activated by small phosphorylated metabolites called phosphoantigens (PAg). Stress-induced changes in target cell PAg levels are specifically detected by butyrophilin (BTN)3A1, using its intracellular B30.2 domain. This leads to the activation of Vγ9Vδ2 T cells. In this study, we show that changes in the juxtamembrane domain of BTN3A1, but not its transmembrane domain, induce a markedly enhanced or reduced γδ T cell reactivity...
May 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
Roberto Cesareo, Andrea Palermo, Valerio Pasqualini, Carla Simeoni, Alessandro Casini, Giuseppe Pelle, Silvia Manfrini, Giuseppe Campagna, Roberto Cianni
Objective: The objective of our study is to evaluate the clinical outcomes and safety of radiofrequency thermal ablation (RFA) for benign thyroid nodules (BTNs) over a 1-year follow-up. Subjects and methods: This is a monocentric retrospective study. Forty-eight patients with solid, non-functioning BTNs were treated by RFA using a 17G internally cooled electrode. We categorized thyroid nodules as small (≤ 12 mL), medium (12 to 30 mL), or large (over 30 mL). BTNs volume reduction, thyroid function, cosmetic and compressive score changes and side effect evaluation at 6 and 12 months were evaluated...
February 13, 2017: Archives of Endocrinology and Metabolism
Juan Wei, Jiangli Dong, Shangjun Zhuo, Rong Qian, Yuanxing Fang, Qiao Chen, Ekbal Patel
A method for signal enhancement utilizing stacked magnets was introduced into high-resolution radio frequency glow discharge-mass spectrometry (rf-GD-MS) for significantly improved analysis of inorganic materials. Compared to the block magnet, the stacked magnets method was able to achieve 50-59% signal enhancement for typical elements in Y2O3, BSO, and BTN samples. The results indicated that signal was enhanced as the increase of discharge pressure from 1.3 to 8.0 mPa, the increase of rf-power from 10 to 50 W with a frequency of 13...
January 17, 2017: Analytical Chemistry
Daniela Iannazzo, Alessandro Pistone, Marina Salamò, Signorino Galvagno, Roberto Romeo, Salvatore V Giofré, Caterina Branca, Giuseppa Visalli, Angela Di Pietro
A biocompatible and cell traceable drug delivery system Graphene Quantum Dots (GQD) based, for the targeted delivery of the DNA intercalating drug doxorubicin (DOX) to cancer cells, is here reported. Highly dispersible and water soluble GQD, synthesized by acidic oxidation and exfoliation of multi-walled carbon nanotubes (MWCNT), were covalently linked to the tumor targeting module biotin (BTN), able to efficiently recognize biotin receptors over-expressed on cancer cells and loaded with DOX. Biological test performed on A549 cells reported a very low toxicity of the synthesized carrier (GQD and GQD-BTN)...
February 25, 2017: International Journal of Pharmaceutics
Cherry Kim, Jeong Hyun Lee, Young Jun Choi, Won Bae Kim, Tae Yon Sung, Jung Hwan Baek
OBJECTIVES: To evaluate the complication rates and describe the possible complications of ultrasonography-guided radiofrequency ablation (RFA) of benign thyroid nodules (BTN) and recurrent thyroid cancers (RTC), and to compare the complication rates between BTN and RTC. METHODS: This retrospective study reviewed 875 patients who underwent RFA for BTN (746 patients; 83.5%) or RTC (129 patients; 14.7%). Medical records were reviewed for all types of complications occurring during and after the RFA procedure...
December 14, 2016: European Radiology
Cristina Lebrero-Fernández, Ulf Alexander Wenzel, Paulina Akeus, Ying Wang, Hans Strid, Magnus Simrén, Bengt Gustavsson, Lars G Börjesson, Susanna L Cardell, Lena Öhman, Marianne Quiding-Järbrink, Anna Bas-Forsberg
Several Butyrophilin (BTN) and Btn-like (BTNL) molecules control T lymphocyte responses, and are genetically associated with inflammatory disorders and cancer. In this study, we present a comprehensive expression analysis of human and murine BTN and BTNL genes in conditions associated with intestinal inflammation and cancer. Using real-time PCR, expression of human BTN and BTNL genes was analyzed in samples from patients with ulcerative colitis, irritable bowel syndrome, and colon tumors. Expression of murine Btn and Btnl genes was examined in mouse models of spontaneous colitis (Muc2(-/-)) and intestinal tumorigenesis (Apc(Min/+))...
June 2016: Immunity, Inflammation and Disease
Wen-Wen Yue, Xiao-Long Li, Hui-Xiong Xu, Feng Lu, Li-Ping Sun, Le-Hang Guo, Ya-Ping He, Dan Wang, Zhi-Qiang Yin
This study is to compare the health-related quality of life (HRQoL) and cost-effectiveness of radiofrequency ablation (RFA) and open thyroidectomy (OT) for benign thyroid nodules (BTNs) treatment. HRQoL and utility were assessed for 404 BTN patients immediately before treatments (RFA:OT = 137:267) and at 6-month visit. A cost-effectiveness analysis was performed from societal perspective in the China context. Resource use (hospitalization, sick leaves) was collected. We used the net monetary benefit approach and computed cost-effectiveness acceptability curves for RFA and OT...
November 24, 2016: Scientific Reports
Jinlei Xu, Shufang Wu, Jingpeng Jin, Tianyou Peng
Brookite TiO2 nanoparticles with small sizes (hereafter denoted as BTP particles) were synthesized through the hydrothermal treatment of TiCl4 solution with Pb(NO3)2 as an additive. The obtained BTP particles have a large specific surface area (∼122.2 m(2) g(-1)) and relatively uniform particle sizes (∼10 nm) with the coexistence of a small quantity of nanorods with a length of ∼100 nm. When used as a photoanode material for dye-sensitized solar cells (DSSCs), the BTP particles show a much higher dye-loading content than the brookite TiO2 quasi nanocubes (denoted as BTN particles) with a mean size of ∼50 nm and a specific surface area of ∼34...
November 1, 2016: Nanoscale
M Cihan Çakır, Deniz Çalışkan, Bayram Bütün, Ekmel Özbay
Metal oxide gas sensors with integrated micro-hotplate structures are widely used in the industry and they are still being investigated and developed. Metal oxide gas sensors have the advantage of being sensitive to a wide range of organic and inorganic volatile compounds, although they lack selectivity. To introduce selectivity, the operating temperature of a single sensor is swept, and the measurements are fed to a discriminating algorithm. The efficiency of those data processing methods strongly depends on temperature uniformity across the active area of the sensor...
September 29, 2016: Sensors
C Anuradha, M T Manipadam, H S Asha, N Dukhabandhu, D Abraham, M J Paul
AIM: To describe two new ultrasound signs for thyroid nodules - "nodule in nodule" and "hypoechoic internal septae" and assess their usefulness in differentiating follicular variant of papillary thyroid carcinoma (FVPTC) from benign thyroid nodules (BTN). METHODOLOGY: Ultrasound findings of 210 patients with histopathologically proven FVPTC (68 nodules, M:F=13:47 with mean age of 39.5±11.9 years) and BTN (165 nodules, (M:F=41:109 with mean age of 44±11.3 years) were retrospectively reviewed from PACS by a single radiologist blinded to the final diagnosis...
May 2016: Ultrasound International Open
Onur Durmaz, Serkan Kemer, Tuba Mutluer, Elif Bütün
INTRODUCTION: The etiology of primary nocturnal enuresis (PNE) is not fully understood, but multifactorial factors have been associated with PNE. Parental factors, including attitudes to PNE, disciplinary behaviors, and psychiatric comorbidities in parents have been related to etiology of PNE, outcomes and the quality of life in children with enuresis. OBJECTIVE: We examined the psychopathology in mothers of children diagnosed with monosymptomatic PNE(MoPNE) compared with mothers of non-enuretic children (MoNEC) in terms of personality characteristics, early traumatic experiences, and psychiatric symptom evaluation...
February 2017: Journal of Pediatric Urology
Ergün Sönmezgöz, Samet Ozer, Resul Yilmaz, Yalçın Önder, Ilknur Bütün, Serap Bilge
BACKGROUND: Vitamin D deficiency or insufficiency may play a role in the pathogenesis of certain autoimmune diseases. AIM: To measure vitamin D levels in children with Hashimoto’s thyroiditis (HT) (either with subclinical or marked hypothyroidism) and in healthy controls. MATERIAL AND METHODS: We included 68 children with HT aged 12 ± 4 years (39 females) from a pediatric outpatient clinic and 68 healthy children aged 10 ± 4 years (37 females)...
May 2016: Revista Médica de Chile
YueHua Li, Liang Chen, YuLong Liu, Fei Liu, Paul H Fallgren, Song Jin
This work investigated the frequently observed "rebounds" of contaminants of concern in groundwater systems. Specifically, influences of bioaugmented microorganisms on the sorption and desorption of representative petroleum constituents [benzene, 1,3,5-trimethylbenzene and naphthalene (BTN)] were studied in freshly-spiked and historically-contaminated sediments. Capable microorganisms were enriched and supplemented to contaminated sediments to enhance biodegradation of petroleum hydrocarbons. In freshly-spiked sediments, when petroleum-degrading microorganisms were added, concentrations of dissolved petroleum constituents appeared to increase initially, and 12...
November 2016: Chemosphere
Jeongwoo Hyun, Maria Abigail, Jin Woo Choo, Jin Ryu, Hyung Kwoun Kim
Glucose dehydrogenase (GDH) is an oxidoreductase enzyme and is used as a biocatalyst to regenerate NAD(P)H in reductase-mediated chiral synthesis reactions. In this study, the glucose 1-dehydrogenase B gene (gdhB) was cloned from Bacillus thuringiensis subsp. kurstaki, and wild-type (GDH-BT(WT)) and His-tagged (GDH-BT(N-His), GDH-BT(C-His)) enzymes were produced in Escherichia coli BL21 (DE3). All enzymes were produced in the soluble forms from E. coli. GDH-BT(WT) and GDH-BT(N-His) showed high specific enzymatic activities of 6...
October 28, 2016: Journal of Microbiology and Biotechnology
David A Rhodes, Walter Reith, John Trowsdale
Butyrophilin molecules (commonly contracted to BTN), collectively take their name from the eponymous protein in cow's milk. They are considered to be members of the B7 family of costimulatory receptors, which includes B7.1 (CD80), B7.2 (CD86), and related molecules, such as PD-L1 (B7-H1, CD274), ICOS-L (CD275), and B7-H3 (CD276). These coreceptors modulate T cell responses upon antigen presentation by major histocompatibility complex and cognate αβ T cell receptor engagement. Molecules such as BTN3A1 (CD277), myelin oligodendrocyte glycoprotein, and mouse Skint1 and Btnl2, all members of the butyrophilin family, show greater structural and functional diversity than the canonical B7 receptors...
May 20, 2016: Annual Review of Immunology
Yang-Jing Chen, Rui-Min Zhao, Qian Zhao, Bai-Ya Li, Qing-Yong Ma, Xiao Li, Xia Chen
This study examined the association between hector battifora mesothelial antigen-1 (HBME-1) expression and papillary thyroid carcinoma (PTC). A total of 206 patients were enrolled in the current study including 96 PTC patients and 110 patients with benign thyroid nodules (BTN). Immunohistochemistry (Envision) were performed to assess the expression of HBME-1. Receiver operating characteristic curve (ROC) curves were applied to evaluate the diagnostic tumor node metastasis (TNM) value of HBME-1. Specimens from 96 patients with PTC and 110 patients with BTC were reviewed...
July 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"