keyword
https://read.qxmd.com/read/38335269/bcl6-is-required-for-the-thymic-development-of-tcr%C3%AE-%C3%AE-cd8%C3%AE-%C3%AE-intraepithelial-lymphocyte-lineage
#21
JOURNAL ARTICLE
Qi Xing, Dehui Chang, Shiyuan Xie, Xiaohong Zhao, Hao Zhang, Xiaohu Wang, Xue Bai, Chen Dong
TCRαβ+ CD8αα+ intraepithelial lymphocytes (CD8αα+ αβ IELs) are a specialized subset of T cells in the gut epithelium that develop from thymic agonist selected IEL precursors (IELps). The molecular mechanisms underlying the selection and differentiation of this T cell type in the thymus are largely unknown. Here, we found that Bcl6 deficiency in αβ T cells resulted in the near absence of CD8αα+ αβ IELs. BCL6 was expressed by approximately 50% of CD8αα+ αβ IELs and by the majority of thymic PD1+ IELps after agonist selection...
September 2, 2024: Science Immunology
https://read.qxmd.com/read/38327516/single-cell-analysis-revealed-that-two-distinct-unique-cd4-t-cell-subsets-were-increased-in-the-small-intestinal-intraepithelial-lymphocytes-of-aged-mice
#22
JOURNAL ARTICLE
Yuki Yonemoto, Yasuhiro Nemoto, Ryo Morikawa, Nana Shibayama, Shigeru Oshima, Takashi Nagaishi, Tomohiro Mizutani, Go Ito, Satoru Fujii, Ryuichi Okamoto
Recent advances in research suggest that aging has a controllable chronic inflammatory disease aspect. Aging systemic T cells, which secrete pro-inflammatory factors, affect surrounding somatic cells, and accelerate the aging process through chronic inflammation, have attracted attention as potential therapeutic targets in aging. On the other hand, there are few reports on the aging of the intestinal immune system, which differs from the systemic immune system in many ways. In the current study, we investigated the age-related changes in the intestinal immune system, particularly in T cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38319266/-pathomorphological-criteria-and-features-of-immune-response-in-eosinophilic-esophagitis-and-reflux-esophagitis
#23
JOURNAL ARTICLE
K S Maslenkina, E N Motylev, M Yu Guschin, R A Vandysheva, L M Mikhaleva
BACKGROUND: Eosinophilic esophagitis (EoE) is an immune-mediated disease, manifested by dysphagia and characterized by intraepithelial infiltration: more than 15 eosinophils per field of view at x400 magnification, and requiring differential diagnosis with reflux esophagitis (RE). OBJECTIVE: To access the implication of EoE histologic scoring system (EoEHSS) for differential diagnosis of EoE and RE and to characterize features of immune response in these diseases...
2024: Arkhiv Patologii
https://read.qxmd.com/read/38302880/extracellular-cirp-induces-cd4cd8%C3%AE-%C3%AE-intraepithelial-lymphocyte-cytotoxicity-in-sepsis
#24
JOURNAL ARTICLE
Yuichi Akama, Atsushi Murao, Monowar Aziz, Ping Wang
BACKGROUND: In sepsis, intestinal barrier dysfunction is often caused by the uncontrolled death of intestinal epithelial cells (IECs). CD4CD8αα intraepithelial lymphocytes (IELs), a subtype of CD4+ T cells residing within the intestinal epithelium, exert cytotoxicity by producing granzyme B (GrB) and perforin (Prf). Extracellular cold-inducible RNA-binding protein (eCIRP) is a recently identified alarmin which stimulates TLR4 on immune cells to induce proinflammatory responses...
February 1, 2024: Molecular Medicine
https://read.qxmd.com/read/38301689/multiplex-analysis-of-intratumoural-immune-infiltrate-and-prognosis-in-patients-with-stage-ii-iii-colorectal-cancer-from-the-scot-and-quasar-2-trials-a-retrospective-analysis
#25
JOURNAL ARTICLE
Anja L Frei, Anthony McGuigan, Ritik R A K Sinha, Faiz Jabbar, Luciana Gneo, Tijana Tomasevic, Andrea Harkin, Tim Iveson, Mark P Saunders, Karin A Oien, Noori Maka, Francesco Pezzella, Leticia Campo, Molly Browne, Mark Glaire, Wanja Kildal, Havard E Danielsen, Jennifer Hay, Joanne Edwards, Owen Sansom, Caroline Kelly, Ian Tomlinson, Rachel Kerr, David Kerr, Enric Domingo, David N Church, Viktor H Koelzer
BACKGROUND: Tumour-infiltrating CD8+ cytotoxic T cells confer favourable prognosis in colorectal cancer. The added prognostic value of other infiltrating immune cells is unclear and so we sought to investigate their prognostic value in two large clinical trial cohorts. METHODS: We used multiplex immunofluorescent staining of tissue microarrays to assess the densities of CD8+ , CD20+ , FoxP3+ , and CD68+ cells in the intraepithelial and intrastromal compartments from tumour samples of patients with stage II-III colorectal cancer from the SCOT trial (ISRCTN59757862), which examined 3 months versus 6 months of adjuvant oxaliplatin-based chemotherapy, and from the QUASAR 2 trial (ISRCTN45133151), which compared adjuvant capecitabine with or without bevacizumab...
February 2024: Lancet Oncology
https://read.qxmd.com/read/38277691/intraepithelial-lymphocytes-of-the-intestine
#26
REVIEW
Ainsley Lockhart, Daniel Mucida, Angelina M Bilate
The intestinal epithelium, which segregates the highly stimulatory lumen from the underlying tissue, harbors one of the largest lymphocyte populations in the body, intestinal intraepithelial lymphocytes (IELs). IELs must balance tolerance, resistance, and tissue protection to maintain epithelial homeostasis and barrier integrity. This review discusses the ontogeny, environmental imprinting, T cell receptor (TCR) repertoire, and function of intestinal IELs. Despite distinct developmental pathways, IEL subsets share core traits including an epithelium-adapted profile, innate-like properties, cytotoxic potential, and limited TCR diversity...
January 26, 2024: Annual Review of Immunology
https://read.qxmd.com/read/38269504/dual-regulation-effect-and-mechanism-of-human-myeloid-derived-suppressor-cells-on-anticolorectal-cancer-cells-activity-of-v%C3%AE-9v%C3%AE-2-t-cells
#27
JOURNAL ARTICLE
Mengyu Zhang, Yuanyuan Wu, Yahan Qin, Jie Shen, Zhao Cui, Fan Lei, Ke Zhang, Baiqing Li, Shujuan Liang, Meiyu Peng
Myeloid-derived suppressor cells (MDSC) are a group of immature inhibitory cells of bone marrow origin. Human γδ T cells (mainly Vγ9Vδ2 T cells) have emerged as dominant candidates for cancer immunotherapy because of their unique recognition pattern and broad killing activity against tumor cells. Intestinal mucosal intraepithelial lymphocytes are almost exclusively γδ T cells, so it plays an important role in inhibiting the development of colorectal cancer. In this study, we investigated the effects and molecular mechanism of human MDSC on anticolorectal cancer cells activity of Vγ9Vδ2 T cells...
January 2024: Cell Biochemistry and Function
https://read.qxmd.com/read/38257124/improving-the-diagnosis-of-dermatitis-herpetiformis-using-the-intraepithelial-lymphogram
#28
JOURNAL ARTICLE
Fernando Fernández-Bañares, Laura Crespo, Montserrat Planella, Sergio Farrais, Sandra Izquierdo, Natalia López-Palacios, Garbiñe Roy, Judith Vidal, Concepción Núñez
Dermatitis herpetiformis is a cutaneous manifestation of celiac disease. Phenotyping of intraepithelial lymphocytes in the small bowel mucosa can strengthen the diagnosis of celiac disease when it is not clear-cut. We aim to evaluate the usefulness of the intraepithelial lymphogram to confirm dermatitis herpetiformis in equivocal cases. We performed a retrospective multicenter study on patients diagnosed with dermatitis herpetiformis and collected data from the intraepithelial lymphogram assessed by flow cytometry...
January 11, 2024: Nutrients
https://read.qxmd.com/read/38255265/altered-expression-of-intestinal-tight-junction-proteins-in-heart-failure-patients-with-reduced-or-preserved-ejection-fraction-a-pathogenetic-mechanism-of-intestinal-hyperpermeability
#29
JOURNAL ARTICLE
Eleni-Evangelia Koufou, Stelios F Assimakopoulos, Pinelopi Bosgana, Anne-Lise de Lastic, Ioanna-Maria Grypari, Georgia-Andriana Georgopoulou, Stefania Antonopoulou, Athanasia Mouzaki, Helen P Kourea, Konstantinos Thomopoulos, Periklis Davlouros
Although intestinal microbiota alterations (dysbiosis) have been described in heart failure (HF) patients, the possible mechanisms of intestinal barrier dysfunction leading to endotoxemia and systemic inflammation are not fully understood. In this study, we investigated the expression of the intestinal tight junction (TJ) proteins occludin and claudin-1 in patients with HF with reduced (HFrEF) or preserved ejection fraction (HFpEF) and their possible association with systemic endotoxemia and inflammation. Ten healthy controls and twenty-eight patients with HF (HFrEF (n = 14), HFpEF (n = 14)) underwent duodenal biopsy...
January 12, 2024: Biomedicines
https://read.qxmd.com/read/38243324/activation-of-mucosal-insulin-receptor-exacerbates-intestinal-inflammation-by-promoting-tissue-resident-memory-t-cells-differentiation-through-ezh2
#30
JOURNAL ARTICLE
Teming Li, Ben Han, Liucan Wang, Lihua Sun, Yujiao Cai, Min Yu, Weidong Xiao, Hua Yang
BACKGROUND: Inflammatory Bowel Diseases (IBD), an autoimmune disease characterised by abnormal intestinal immunity, are related to vital morbidity around the world. However, therapeutic agents for IBD have not achieved desired benefit. Exploring new therapeutic targets for IBD, especially based on its abnormally intestinal immunity, could alleviate the flare-up and worsening of IBD. Tissue resident memory T cells (TRM) are core of multiple autoimmune diseases, including IBD. However, the mechanism of TRM differentiation remains to be investigated...
January 19, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38229169/a-promising-new-model-establishment-of-patient-derived-organoid-models-covering-hpv-related-cervical-pre-cancerous-lesions-and-their-cancers
#31
JOURNAL ARTICLE
Bai Hu, Renjie Wang, Di Wu, Rui Long, Junpeng Fan, Zhe Hu, Xingyuan Hu, Ding Ma, Fang Li, Chaoyang Sun, Shujie Liao
The lack of human-derived in vitro models that recapitulate cervical pre-cancerous lesions has been the bottleneck in researching human papillomavirus (HPV) infection-associated pre-cancerous lesions and cancers for a long time. Here, a long-term 3D organoid culture protocol for high-grade squamous intraepithelial lesions and cervical squamous cell carcinoma that stably recapitulates the two tissues of origin is described. Originating from human-derived samples, a small biobank of cervical pre-tumoroids and tumoroids that faithfully retains genomic and transcriptomic characteristics as well as the causative HPV genome is established...
January 16, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38198036/screening-for-precancerous-anal-lesions-linked-to-human-papillomaviruses-french-recommendations-for-clinical-practice
#32
REVIEW
L Spindler, I Etienney, L Abramowitz, V de Parades, F Pigot, L Siproudhis, J Adam, V Balzano, D Bouchard, N Bouta, M Bucau, A Carlo, J Chanal, C Charpentier, G Clifford, M Draullette, N Fathallah, V Ferré, J-F Fléjou, S Fouéré, T Higuero, L Kassouri, S Kurt, A Laurain, E Leclerc, Q Lepiller, A-C Lesage, D Mège, A Ménard, P Merle, P Mortreux, C Noël, H Péré, J-L Prétet, D Roland, G Staumont, L Tracanelli, L Vuitton, S Wylomanski, O Zaegel-Faucher
In France, about 2000 new cases of anal cancer are diagnosed annually. Squamous cell carcinoma is the most common histological type, mostly occurring secondary to persistent HPV16 infection. Invasive cancer is preceded by precancerous lesions. In addition to patients with a personal history of precancerous lesions and anal cancer, three groups are at very high risk of anal cancer: (i) men who have sex with men and are living with HIV, (ii) women with a history of high-grade squamous intraepithelial lesions (HSILs) or vulvar HPV cancer, and (iii) women who received a solid organ transplant more than 10 years ago...
January 10, 2024: Techniques in Coloproctology
https://read.qxmd.com/read/38177282/multimodal-profiling-reveals-site-specific-adaptation-and-tissue-residency-hallmarks-of-%C3%AE-%C3%AE-t-cells-across-organs-in-mice
#33
JOURNAL ARTICLE
Anastasia du Halgouet, Kerstin Bruder, Nina Peltokangas, Aurélie Darbois, David Obwegs, Marion Salou, Robert Thimme, Maike Hofmann, Olivier Lantz, Sagar
γδ T cells perform heterogeneous functions in homeostasis and disease across tissues. However, it is unclear whether these roles correspond to distinct γδ subsets or to a homogeneous population of cells exerting context-dependent functions. Here, by cross-organ multimodal single-cell profiling, we reveal that various mouse tissues harbor unique site-adapted γδ subsets. Epidermal and intestinal intraepithelial γδ T cells are transcriptionally homogeneous and exhibit epigenetic hallmarks of functional diversity...
January 4, 2024: Nature Immunology
https://read.qxmd.com/read/38127067/commensal-bacteria-maintain-a-qa-1-b-restricted-unconventional-cd8-t-population-in-gut-epithelium
#34
JOURNAL ARTICLE
Jian Guan, J David Peske, Michael Manoharan Valerio, Chansu Park, Ellen A Robey, Scheherazade Sadegh-Nasseri
Intestinal intraepithelial lymphocytes (IELs) are characterized by an unusual phenotype and developmental pathway, yet their specific ligands and functions remain largely unknown. Here by analysis of QFL T cells, a population of CD8+ T cells critical for monitoring the MHC I antigen processing pathway, we established that unconventional Qa-1b -restricted CD8+ T cells are abundant in intestinal epithelium. We found that QFL T cells showed a Qa-1b -dependent unconventional phenotype in the spleen and small intestine of naïve wild-type mice...
December 21, 2023: ELife
https://read.qxmd.com/read/38113888/central-glucagon-like-peptide-1-receptor-activation-inhibits-toll-like-receptor-agonist-induced-inflammation
#35
JOURNAL ARTICLE
Chi Kin Wong, Brent A McLean, Laurie L Baggio, Jacqueline A Koehler, Rola Hammoud, Nikolaj Rittig, Julian M Yabut, Randy J Seeley, Theodore J Brown, Daniel J Drucker
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) exert anti-inflammatory effects relevant to the chronic complications of type 2 diabetes. Although GLP-1RAs attenuate T cell-mediated gut and systemic inflammation directly through the gut intraepithelial lymphocyte GLP-1R, how GLP-1RAs inhibit systemic inflammation in the absence of widespread immune expression of the GLP-1R remains uncertain. Here, we show that GLP-1R activation attenuates the induction of plasma tumor necrosis factor alpha (TNF-α) by multiple Toll-like receptor agonists...
January 2, 2024: Cell Metabolism
https://read.qxmd.com/read/38098486/a-novel-anti-galectin-9-immunotherapy-limits-the-early-progression-of-pancreatic-neoplastic-lesions-in-transgenic-mice
#36
JOURNAL ARTICLE
Alexandre Quilbe, Rami Mustapha, Belinda Duchêne, Abhishek Kumar, Elisabeth Werkmeister, Emmanuelle Leteurtre, Olivier Moralès, Nicolas Jonckheere, Isabelle Van Seuningen, Nadira Delhem
BACKGROUND: Pancreatic adenocarcinoma (PDAC) is a devastating disease with an urgent need for therapeutic innovation. Immune checkpoint inhibition has shown promise in a variety of solid tumors, but most clinical trials have failed to demonstrate clinical efficacy in PDAC. This low efficacy is partly explained by a highly immunosuppressive microenvironment, which dampens anti-tumor immunity through the recruitment or induction of immunosuppressive cells, particularly regulatory T cells (Tregs)...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38089980/the-relationship-between-the-expression-of-stathmin-and-tumor-immune-cell-infiltration-in-primary-cervical-carcinoma-and-its-prognostic-diagnostic-value
#37
JOURNAL ARTICLE
Hui Yang, Hongjuan Li, Xiaoke Tang, Jingyu Zhang, Xiaolin Zhang
To analyse the relationship between the Stathmin expression and the tumor immune cell infiltration in primary cervical carcinoma (CC), and its prognostic diagnostic value. Cervical tissue samples from 128 patients admitted to our hospital from February 2021 to February 2022 who underwent hysterectomy or cervical biopsy were selected as the observation objects, and then divided into control group (normal cervical tissue specimen, n = 30), cervical intraepithelial neoplasia (CIN) group (CIN neoplasia cervical tissue specimen, n = 30), and cervical cancer group (cervical tissue specimen of cervical cancer lesion, n = 68) according to pathological results...
December 2023: Heliyon
https://read.qxmd.com/read/38072403/intraepithelial-lymphocytes-are-associated-with-epithelial-injury-in-feline-intestinal-t-cell-lymphoma
#38
JOURNAL ARTICLE
Tatsuhito Ii, James K Chambers, Ko Nakashima, Yuko Goto-Koshino, Kazuyuki Uchida
Our previous study indicated that cytotoxicity of intraepithelial lymphocytes is a poor prognostic factor in feline intestinal T-cell lymphoma (FITL), but the effect of cytotoxic lymphocytes on mucosal epithelium is still unknown. Thus, we investigated the association between cytotoxic lymphocytes and mucosal epithelium in 71 cases of feline intestinal T-cell lymphoma (FITL): epithelial injury, basement membrane injury, cleaved-caspase-3 positivity of epithelial cells, and the number and Ki67 positivity of intraepithelial lymphocytes in granzyme B (GRB)+ and GRB- FITLs were evaluated...
December 8, 2023: Journal of Veterinary Medical Science
https://read.qxmd.com/read/38062230/association-of-whsc1-nsd2-and-t-cell-infiltration-with-prostate-cancer-metastasis-and-prognosis
#39
JOURNAL ARTICLE
Qiheng Li, Jiang Zhu, Yang Zhang, Yun Pan, Zhengjin Li, Min Wang, Yixuan Gao, Dongmei Feng, Xiaoyong He, Chunmei Zhang
Progress in immunotherapy for prostate cancer (PCa) lags that for other cancers, mainly because of limited immune infiltration in PCa. This study aimed to assess the feasibility of NSD2 as an immunotherapeutic target in PCa. Immunohistochemistry was performed to evaluate the expression pattern of NSD2 in 34 cases of benign prostatic hyperplasia (BPH), 36 cases of prostatic intraepithelial neoplasia (PIN), and 57 cases of PCa, including 19 cases of metastatic castration-resistant prostatic cancer (mCRPC). Single-cell RNA sequencing and gene set enrichment analysis (GSEA) were used to correlate NSD2 with certain downstream pathways...
December 7, 2023: Scientific Reports
https://read.qxmd.com/read/38052207/dietary-environmental-factors-shape-the-immune-defense-against-cryptosporidium-infection
#40
JOURNAL ARTICLE
Muralidhara Rao Maradana, N Bishara Marzook, Oscar E Diaz, Tapoka Mkandawire, Nicola Laura Diny, Ying Li, Anke Liebert, Kathleen Shah, Mauro Tolaini, Martin Kváč, Brigitta Stockinger, Adam Sateriale
Cryptosporidium is a leading cause of diarrheal-related deaths in children, especially in resource-poor settings. It also targets the immunocompromised, chronically infecting people living with HIV and primary immunodeficiencies. There is no vaccine or effective treatment. Although it is known from human cases and animal models that CD4+ T cells play a role in curbing Cryptosporidium, the role of CD8+ T cells remains to be defined. Using a Cryptosporidium tyzzeri mouse model, we show that gut-resident CD8+ intraepithelial lymphocytes (IELs) confer resistance to parasite growth...
November 28, 2023: Cell Host & Microbe
keyword
keyword
120118
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.