Ilija Crnčec, Madhura Modak, Claire Gordziel, Jasmin Svinka, Irene Scharf, Stefan Moritsch, Paulina Pathria, Michaela Schlederer, Lukas Kenner, Gerald Timelthaler, Mathias Müller, Birgit Strobl, Emilio Casanova, Editha Bayer, Thomas Mohr, Johannes Stöckl, Karlheinz Friedrich, Robert Eferl
The interferon-inducible transcription factor STAT1 is a tumor suppressor in various malignancies. We investigated sex-specific STAT1 functions in colitis and colitis-associated colorectal cancer (CRC) using mice with specific STAT1 deletion in intestinal epithelial cells (STAT1 ∆ IEC ). Male but not female STAT1 ∆ IEC mice were more resistant to DSS-induced colitis than sex-matched STAT1 flox/flox controls and displayed reduced intraepithelial infiltration of CD8 + TCRαβ + Granzyme B + T cells. Moreover, DSS treatment failed to induce expression of T cell-attracting chemokines in intestinal epithelial cells of male but not of female STAT1 ∆ IEC mice...
February 8, 2018: Molecular Oncology