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https://www.readbyqxmd.com/read/29222090/gpr55-regulates-intraepithelial-lymphocyte-migration-dynamics-and-susceptibility-to-intestinal-damage
#1
Hayakazu Sumida, Erick Lu, Hsin Chen, Qiyun Yang, Ken Mackie, Jason G Cyster
Intraepithelial lymphocytes (IELs) of the small intestine are intimately associated with the epithelial cells. Yet, the factors controlling their migration and interaction dynamics are poorly understood. We demonstrate that GPR55, a receptor that mediates migration inhibition in response to lysophosphatidylinositol (LPI), negatively regulates T cell receptor γδ (TCRγδ) IEL accumulation in the small intestine. Intravital imaging studies show that GPR55-deficient IELs migrate faster and interact more extensively with epithelial cells...
December 8, 2017: Science Immunology
https://www.readbyqxmd.com/read/29221933/intestinal-intraepithelial-lymphocytes-sentinels-of-the-mucosal-barrier
#2
REVIEW
Danyvid Olivares-Villagómez, Luc Van Kaer
Intestinal intraepithelial lymphocytes (IELs) are a large and diverse population of lymphoid cells that reside between the intestinal epithelial cells (IECs) that form the intestinal mucosal barrier. Although IEL biology has traditionally focused on T cells, recent studies have identified several subsets of T cell receptor (TCR)-negative IELs with intriguing properties. New insight into the development, homeostasis, and functions of distinct IEL subsets has recently been provided. Additional studies have revealed intricate interactions between different IEL subsets, reciprocal interactions between IELs and IECs, and communication of IELs with immune cells that reside outside the intestinal epithelium...
December 5, 2017: Trends in Immunology
https://www.readbyqxmd.com/read/29215531/human-immunodeficiency-virus-hiv-and-non-hiv-associated-immunosuppression-and-risk-of-cervical-neoplasia
#3
Michael J Silverberg, Wendy A Leyden, Aileen Chi, Steven Gregorich, Megan J Huchko, Shalini Kulasingam, Miriam Kuppermann, Anna Seto, Karen K Smith-McCune, George F Sawaya
OBJECTIVE: To estimate the risk of cervical intraepithelial neoplasia grade 2, 2-3, 3, adenocarcinoma in situ, or cancer (CIN 2 or worse) among women with human immunodeficiency virus (HIV)- and non-HIV-associated immunosuppression. METHODS: We performed a case-control study of 20,146 women with incident CIN 2 or worse and 5:1 age-matched, incidence-density selected women in a control group (n=100,144) enrolled in an integrated health care system from 1996 to 2014...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29159802/adenovirus-vector-based-prime-boost-vaccination-via-heterologous-routes-induces-cervicovaginal-cd8-t-cell-responses-against-hpv16-oncoproteins
#4
Nicolas Çuburu, Selina Khan, Cynthia D Thompson, Rina Kim, Jort Vellinga, Roland Zahn, Douglas R Lowy, Gert Scheper, John T Schiller
Recent advances in immunotherapy against cancer underscore the importance of T lymphocytes and tumor microenvironment, but few vaccines targeting cancer have been approved likely due in part to the dearth of common tumor antigens, insufficient immunogenicity and the evolution of immune evasion mechanisms during the progression to malignancy. Human papillomaviruses (HPV) are the primary etiologic agents of cervical cancer and progression from persistent HPV-infection to cervical intraepithelial lesions and eventually cancer requires persistent expression of the oncoproteins E6 and E7...
November 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29154854/chicken-il-17a-is-expressed-in-%C3%AE-%C3%AE-and-%C3%AE-%C3%AE-t-cell-subsets-and-binds-to-a-receptor-present-on-macrophages-and-t-cells
#5
Isabelle Walliser, Thomas W Göbel
IL-17A as important cytokine in host defense has been analysed intensively and various homologous have been identified. To further gain insight into the functional properties of chicken (gg) IL-17A its expression profile was analysed by intracellular cytokine staining. In splenocytes and peripheral blood mononuclear cells gg IL-17A was detected in subsets of CD4(+) T cells and γδ T cells. In contrast the gg IL-17A producing populations in intestinal intraepithelial lymphocytes were characterized as either CD3(+)CD25(+) cells or γδ T cells...
November 14, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29154448/significance-of-bizarre-cells-in-cervical-screening-liquid-based-cytology-a-prospective-study-of-15-cases
#6
O Ondič, R Ferko, J Kičinová, J Bouda, I Kinkorová-Luňáčková, L Kupcová, M Zůchová, J Chytra, T Waloschek, M Tůmová Bartošková, R Alaghehbandan, J Němcová
OBJECTIVE: The aim of this study was to assess the significance of bizarre cells (cells of squamous origin with a superficial squamous cell-type cytoplasm and characterised by multinucleation that produces bizarre nuclear shapes) in liquid-based cytology (LBC) Papanicoaou (pap) smears with clinical and histological follow-up correlation. METHODS: Fifteen patients, all with LBC samples containing bizarre cells, were identified in routine ThinPrep(®) LBC workload...
November 20, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29132961/title-experimental-asthma-persists-in-il33-receptor-knockout-mice-due-to-the-emergence-of-a-tslp-driven-il9-and-il13-ilc2-subpopulations
#7
Mukesh Verma, Sucai Liu, Lidia Michalec, Anand Sripada, Magdalena M Gorska, Rafeul Alam
BACKGROUND: IL33 plays an important role in development of experimental asthma. OBJECTIVE: To study the role of the IL33 receptor (ST2) in persistence of asthma in a mouse model. METHODS: We studied allergen-induced experimental asthma in ST2 knockout (KO) and wild-type control mice. We measured airway hyperresponsiveness (AHR) by flexivent, inflammatory indices by ELISA, histology and real-time PCR, and ILC2s in lung single cell preparations by flow cytometry...
November 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29105795/foxp3-regulatory-t-cells-in-normal-prostate-tissue-postatrophic-hyperplasia-prostatic-intraepithelial-neoplasia-and-tumor-histological-lesions-in-men-with-and-without-prostate-cancer
#8
Sabina Davidsson, Ove Andren, Anna-Lena Ohlson, Jessica Carlsson, Swen-Olof Andersson, Francesca Giunchi, Jennifer R Rider, Michelangelo Fiorentino
BACKGROUND: The tumor promoting or counteracting effects of the immune response to cancer development are thought to be mediated to some extent by the infiltration of regulatory T cells (Tregs ). In the present study we evaluated the prevalence of Treg populations in stromal and epithelial compartments of normal, post atrophic hyperplasia (PAH), prostatic intraepithelial neoplasia (PIN), and tumor lesions in men with and without prostate cancer. METHODS: Study subjects were 102 men consecutively diagnosed with localized prostate cancer undergoing radical prostatectomy and 38 men diagnosed with bladder cancer undergoing cystoprostatectomy without prostate cancer at the pathological examination...
November 6, 2017: Prostate
https://www.readbyqxmd.com/read/29099694/cervical-transformation-in-alcohol-abuse-patients
#9
M Lytvynenko, T Bocharova, N Zhelezniakova, T Narbutova, V Gargin
Patients with alcohol consumption have unclear risk of developing cervical cancer. The purpose of our work was detection of cervical neoplastic transformation in women with alcohol abuse. We investigated 13 cases of cervical neoplastic transformation (5 cases of invasive carcinoma and 8 case of cervical intraepithelial neoplasia (CIN)) which where detected occasionally during autopsy of alcohol abuse women. Microscopic investigation with immunohistochemistry (IHC) was performed indirect to Ki-67, p16. There are some peculiarities in development of cervical cancer in women with alcohol consumption...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29083384/why-oats-are-safe-and-healthy-for-celiac-disease-patients
#10
REVIEW
Luud J W J Gilissen, Ingrid M van der Meer, Marinus J M Smulders
The water-insoluble storage proteins of cereals (prolamins) are called "gluten" in wheat, barley, and rye, and "avenins" in oat. Gluten can provoke celiac disease (CD) in genetically susceptible individuals (those with human leukocyte antigen (HLA)-DQ2 or HLA-DQ8 serotypes). Avenins are present at a lower concentration (10%-15% of total protein content) in oat as compared to gluten in wheat (80%-85%). The avenins in the genus Avena (cultivated oat as well as various wild species of which gene bank accessions were analyzed) are free of the known CD immunogenic epitopes from wheat, barley, and rye...
November 26, 2016: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29079467/toxoplasma-gondii-infection-causes-structural-changes-in-the-jejunum-of-rats-infected-with-different-inoculum-doses
#11
Suellen Laís Vicentino-Vieira, Marcelo Biondaro Góis, Aline Rosa Trevizan, Lainy Leiny de Lima, Elen Paula Leatte, Gessilda de Alcântara Nogueira de Melo, João Luiz Garcia, Eduardo José de Almeida Araújo, Débora de Mello Gonçales Sant'Ana
AIM: To evaluate the mucosal tunic and submucosal plexus of the jejunum of rats infected with different inoculum doses of Toxoplasma gondii. MAIN METHODS: Rats were infected with different inoculum doses (50, 500, 1000 and 5000 oocysts) of the T. gondii for 30days, while a control group (CG) received saline solution. Blood and feces were collected before euthanasia for analysis of blood and fecal leukocytes (LEs). Histological analysis of the mucosa, submucosa, villi, crypts and enterocytes were performed...
October 25, 2017: Life Sciences
https://www.readbyqxmd.com/read/29075318/t-and-nk-cell-populations-with-regulatory-phenotype-and-markers-of-apoptosis-in-circulating-lymphocytes-of-patients-with-cin3-or-microcarcinoma-of-the-cervix-evidence-for-potential-mechanisms-of-immune-suppression
#12
Olga V Kurmyshkina, Pavel I Kovchur, Ludmila V Schegoleva, Tatyana O Volkova
BACKGROUND: Processes and mechanisms responsible for systemic immune suppression in early-stage cervical cancer remain substantially underinvestigated. In this work, we focused on studying the frequencies of circulating regulatory T (CD4 and CD8 Tregs) and NK (NKregs) cells in parallel with assessment of apoptotic markers expression in T cells from patients with preinvasive and microinvasive cervical cancer, with the aim to determine whether up-regulation of apoptosis-associated markers in Т lymphocytes accompanies cervical cancer development and correlates with the change in percentages of regulatory cell populations at systemic level during the initial stages of invasive cervical cancer progression...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29075263/intestinal-barrier-interactions-with-specialized-cd8-t-cells
#13
REVIEW
Špela Konjar, Cristina Ferreira, Birte Blankenhaus, Marc Veldhoen
The trillions of microorganisms that reside in the gastrointestinal tract, essential for nutrient absorption, are kept under control by a single cell barrier and large amounts of immune cells. Intestinal epithelial cells (IECs) are critical in establishing an environment supporting microbial colonization and immunological tolerance. A large population of CD8(+) T cells is in direct and constant contact with the IECs and the intraepithelial lymphocytes (IELs). Due to their location, at the interphase of the intestinal lumen and external environment and the host tissues, they seem ideally positioned to balance immune tolerance and protection to preserve the fragile intestinal barrier from invasion as well as immunopathology...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29073638/intratumoural-pd-l1-expression-is-associated-with-worse-survival-of-patients-with-epstein-barr-virus-associated-gastric-cancer
#14
An Na Seo, Byung Woog Kang, Oh Kyoung Kwon, Ki Bum Park, Seung Soo Lee, Ho Young Chung, Wansik Yu, Han Ik Bae, Seong Woo Jeon, Hyojeung Kang, Jong Gwang Kim
BACKGROUND: This study investigated the clinical relevance and prognostic impact of the overall expression of programmed cell death protein ligand-1 (PD-L1) and programmed cell death protein ligand-2 (PD-L2), in patients with Epstein-Barr virus-associated gastric cancer (EBVaGC). METHODS: After reviewing 1318 consecutive cases of surgically resected or endoscopic submucosal dissected gastric cancers, the expression status of PD-L1 and PD-L2 in 120 patients with EBVaGC identified by EBV-encoded RNA in situ hybridisation was retrospectively analysed using immunohistochemistry (IHC)...
December 5, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29050410/effect-of-feeding-soybean-meal-and-differently-processed-peas-on-intestinal-morphology-and-functional-glucose-transport-in-the-small-intestine-of-broilers
#15
I Röhe, F Goodarzi Boroojeni, J Zentek
Peas are locally grown legumes being rich in protein and starch. However, the broad usage of peas as a feed component in poultry nutrition is limited to anti-nutritional factors, which might impair gut morphology and function. This study investigated the effect of feeding raw or differently processed peas compared with feeding a soybean meal-based control diet (C) on intestinal morphology and nutrient transport in broilers. A total of 360 day-old broiler chicks were fed with one of the following diets: The C diet, and 3 diets containing raw peas (RP), fermented peas (FP) and enzymatically pre-digested peas (EP), each supplying 30% of dietary crude protein...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29025424/understanding-immune-phenotypes-in-human-gastric-disease-tissues-by-multiplexed-immunohistochemistry
#16
Le Ying, Feng Yan, Qiaohong Meng, Xiangliang Yuan, Liang Yu, Bryan R G Williams, David W Chan, Liyun Shi, Yugang Tu, Peihua Ni, Xuefeng Wang, Dakang Xu, Yiqun Hu
BACKGROUND: Understanding immune phenotypes and human gastric disease in situ requires an approach that leverages multiplexed immunohistochemistry (mIHC) with multispectral imaging to facilitate precise image analyses. METHODS: We developed a novel 4-color mIHC assay based on tyramide signal amplification that allowed us to reliably interrogate immunologic checkpoints, including programmed death-ligand 1 (PD-L1), cytotoxic T cells (CD8(+)T) and regulatory T cells (Foxp3), in formalin-fixed, paraffin-embedded tissues of various human gastric diseases...
October 12, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28985196/inflammatory-stroma-of-lymphoepithelioma-like-carcinoma-of-the-cervix-immunohistochemical-study-of-3-cases-and-review-of-the-literature
#17
Amandine Philippe, Marc Rassy, Ligia Craciun, Céline Naveaux, Karen Willard-Gallo, Denis Larsimont, Isabelle Veys
The aim of this study was to characterize the inflammatory infiltrate of the lymphoepithelioma-like carcinoma, a variant of squamous cell carcinoma clinically associated with a good prognosis. Immunohistochemistry was used to characterize 3 cases of lymphoepithelioma-like carcinoma in the uterine cervix, diagnosed over a period of 3 yr. The patients were between 30 and 50 yr old. Their cervical smears had shown atypical squamous cells of unknown significance or high-grade squamous intraepithelial lesions, and the initial cervical biopsy showed high-grade cervical intraepithelial neoplasia (CIN3) or squamous cell carcinoma...
August 1, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28968881/immune-microenvironments-of-anal-cancer-precursors-differ-by-hiv-serostatus-affecting-ablation-outcomes
#18
Yuxin Liu, Michael M Gaisa, Xiaofei Wang, Talia H Swartz, Yotam Arens, Karen A Dresser, Carlie Sigel, Keith Sigel
Background: Anal high-grade squamous intraepithelial lesions (HSILs) are the precursors to anal cancer and frequently persist or recur following electrocautery ablation (EA). Impaired mucosal immunity may facilitate anal carcinogenesis. We characterized the immune microenvironment of anal HSIL in correlation with HIV-serostatus and ablation outcomes. Methods: Using immunohistochemistry, mucosa-infiltrating CD4+ and CD8+ lymphocytes were quantified in HSIL and benign mucosa from 70 HIV+ and 45 HIV- patients...
September 2, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28967957/colon-immune-related-adverse-events-anti-ctla-4-and-anti-pd-1-blockade-induce-distinct-immunopathological-entities
#19
Clélia Coutzac, Julien Adam, Emilie Soularue, Michael Collins, Antoine Racine, Charlotte Mussini, Lisa Boselli, Nyam Kamsukom, Christine Mateus, Mélinda Charrier, Lydie Cassard, David Planchard, Vincent Ribrag, Karim Fizazi, Yohann Loriot, Patricia Lepage, Jean-Yves Scoazec, Caroline Robert, Franck Carbonnel, Nathalie Chaput
Background and Aim: Immune checkpoint inhibitors targeting CTLA-4 and PD-1 improve survival in cancer patients but may induce immune-related adverse events, including colitis. The immunological characteristics of anti-CTLA-4 [αCTLA-4]- and anti-PD-1 [αPD-1]-related colitis have been poorly described. The aim of the present study was to compare the immunological and histological characteristics of αCTLA-4-induced colitis and αPD-1-induced colitis. Methods: Colonic biopsies from patients with αCTLA-4-induced colitis, αPD-1-induced colitis, and inflammatory bowel disease [IBD] were analysed by immunohistochemistry and flow cytometry...
October 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28958836/in-vivo-blockade-of-t-cell-development-reveals-alternative-pathways-for-generation-of-intraepithelial-lymphocytes-in-mice
#20
Surenchimeg Mondoon, Kensuke Shibata, Yasunobu Yoshikai
Intraepithelial lymphocytes (IELs) are resident cells localized within the intestinal epithelia and play an important role in regulating gut inflammations and host defense against pathogens. CD8α(+) TCRαβ(+) IELs are heterogeneous populations that are generated from T cell precursors including CD4(-) CD8α(-) double-negative (DN) cells and CD4(+) CD8α(+) double-positive (DP) cells. However, developmental pathways of TCRαβ(+) IELs remained unclear. To gain insight into the mechanisms, we generated mice (Bcl11b(ΔDN2) mice) that lack thymic precursors (DN CD5(+) TCRβ(+) cells) for CD4(-) CD8αα(+) TCRαβ(+) IELs...
November 2017: Immunology Letters
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