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https://www.readbyqxmd.com/read/29775005/-determination-and-significance-of-serum-mpo-and-amylin-in-adult-patients-with-osahs-after-short-range-noninvasive-positive-pressure-ventilation
#1
X H Chen, P J Chen, Y Long, Q P Huang
Objective: The aim of this study to investigate the determination and significance of serum MPO and amylin in adult patients with OSAHS after short-range noninvasive positive pressure ventilation. Method: Eighty-seven OSAHS patients were divided into severe group (30 cases), moderate group (30 cases) and mild group (27 cases) according to the AHI range. Twenty-seven outpatient health persons were selected as the control group. Serum amylin and myeloperoxidase were measured by ELISA; Amyloid and myeloperoxidase were reassessed in 30 patients with severe OSAHS after 6 months of combined therapy, and the relationship between amylin, myeloperoxidase and PSG was analyzed...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775001/-expression-and-significance-of-serum-hepatocyte-growth-factor-and-myeloperoxidase-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#2
L B Liao, J M Zhai, G G Chen, Z E Ma, X B Yang, J G Zhang
Objective: The aim of this study is to explore the expression and significance of serum HGF and MPO in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) in adults. Method: Ninety-six cases of OSAHS patients diagnosed by PSG were divided into 3 groups: Heavy, medium and light according to the range of AHI; 32 cases of outpatients were healthy persons as the control group. The serum HGF and MPO were determined by ELISA; HGF and MPO were measured after comprehensive treat with CPAP in patients with severe OSAHS, and the correlation between HGF, MPO and PSG were analyzed...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29773460/cpap-therapy-improves-erectile-function-in-patients-with-severe-obstructive-sleep-apnea
#3
Richard Schulz, Fabian Bischoff, Wolfgang Galetke, Henning Gall, Jörg Heitmann, Andrea Hetzenecker, Markus Laudenburg, Till Jonas Magnus, Georg Nilius, Christina Priegnitz, Winfried Randerath, Maik Schröder, Marcel Treml, Michael Arzt
OBJECTIVES: Erectile dysfunction (ED) is highly prevalent in obstructive sleep apnea (OSA), however, the effect of continuous positive airway pressure (CPAP) therapy on erectile function has not yet been thoroughly investigated in these patients. METHODS: Ninety-four men with severe OSA (ie, with an apnea-hypopnea-index ≥ 30/h of sleep) were prospectively evaluated for the presence and severity of ED before and after 6-12 months of CPAP therapy. The abbreviated version of the International Index of Erectile Function, (the IIEF-5) was used to rate erectile function...
April 10, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29773211/treating-obstructive-sleep-apnea-with-continuous-positive-airway-pressure-reduces-risk-of-recurrent-atrial-fibrillation-after-catheter-ablation-a-meta-analysis
#4
REVIEW
Feilong Deng, Ali Raza, Jun Guo
INTRODUCTION: Recent studies have suggested that there is a strong relationship between obstructive sleep apnea (OSA) and atrial fibrillation (AF). However, they have not identified whether treating OSA with continuous positive airway pressure (CPAP) might reduce rates of recurrent AF. OBJECTIVE: To investigate the recurrent risk of AF after catheter ablation among patients with OSA who did receive or did nor receive CPAP therapy. METHODS: A systematic review of PubMed, Embase, Medline, Cochrane library, China National Knowledge Infrastructure (CNKI) and Wan-fang databases was conducted to obtain relevant cohort studies and randomized controlled trials (RCTs)...
June 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29771034/-a-preliminary-clinical-classification-study-in-rem-related-obstructive-sleep-apnea
#5
K L Jiang, L Zhao, S N Li, Z Q Lin, Y M Ma, M A Iqbal, W Qian
Objective: The aim of this study is to introduce a method in classifying the REM related OSA (RrOSA) and the potential clinical significance. Method: Two hundred and fifty patients (male: 219) with OSAS diagnosed by polysomnographywere recruited in the study. The RrOSAS was defined as the ratio of AHIs in REM and non REM sleep (R) greater than one. In RrOSAS group, patients were divided into RrOSAS Ⅰa (R>2, NREM_AHI<15), RrOSAS Ⅰb (R>2, NREM_AHI>15), and RrOSAS II (2>R>1) three subtypes...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29762755/obstructive-sleep-apnea-during-rem-sleep-is-associated-with-early-signs-of-atherosclerosis-in-women
#6
Mirjam Ljunggren, Eva Lindberg, Karl A Franklin, Patrik Öhagen, Marita Larsson, Jenny Theorell-Haglöw, Tord Naessén
Study Objectives: While obstructive sleep apnea (OSA) is associated with overall cardiovascular disease and mortality, the association with atherosclerotic cardiovascular disease is less clear, especially in women. Recently, it has been suggested that OSA during REM sleep, associated with long apneas and deep desaturations, could have severe cardio-metabolic consequences. The aim of this study was to investigate whether OSA during REM sleep is associated with early signs of atherosclerosis in a population-based sample of women...
May 14, 2018: Sleep
https://www.readbyqxmd.com/read/29756614/transoral-glossoepiglottopexy-in-the-treatment-of-adult-obstructive-sleep-apnoea-a-surgical-approach
#7
V Roustan, M Barbieri, F Incandela, F Missale, H Camera, F Braido, R Mora, G Peretti
The treatment of obstructive sleep apnoea syndrome (OSAS) is still a matter of debate; among the different therapeutic alternatives, both surgical and conservative, treatment with continuous positive airway pressure (CPAP) is considered the "gold standard". The recent scientific literature reports that even if CPAP represents an effective solution for sleep apnoeas, 12% of patients do not benefit from its use. In most cases, primary collapse of the epiglottis is responsible for failure. We developed a surgical technique that provides a stable support to the epiglottis without influencing its function during swallowing while preserving laryngeal anatomy and physiology...
February 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29752170/treating-obstructive-sleep-apnea-and-chronic-intermittent-hypoxia-improves-the-severity-of-nonalcoholic-fatty-liver-disease-in-children
#8
Shikha S Sundaram, Ann C Halbower, Jelena Klawitter, Zhaoxing Pan, Kristen Robbins, Kelley E Capocelli, Ronald J Sokol
OBJECTIVE: To determine the effects of treating obstructive sleep apnea/nocturnal hypoxia on pediatric nonalcoholic fatty liver disease (NAFLD) severity and oxidative stress. STUDY DESIGN: Biopsy proven participants (n = 9) with NAFLD and obstructive sleep apnea/hypoxia were studied before and after treatment with continuous positive airway pressure (CPAP) for sleep disordered breathing, including laboratory testing and markers of oxidative stress, urine F(2)-isoprostanes...
May 8, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29750475/effects-of-losartan-and-allopurinol-on-cardiorespiratory-regulation-in-obstructive-sleep-apnoea
#9
Barbara J Morgan, Mihaela Teodorescu, David F Pegelow, Emily R Jackson, Devin L Schneider, David T Plante, James P Gapinski, Scott J Hetzel, John M Dopp
Chemoreflex sensitization produced by chronic intermittent hypoxia (CIH) in rats is attenuated by angiotensin II type 1 receptor (AT1 R) blockade. AT1 R blockade and xanthine oxidase inhibition both ameliorate CIH-induced endothelial dysfunction. We hypothesized treatment with losartan and allopurinol would reduce chemoreflex sensitivity and improve hypoxic vasodilation in patients with obstructive sleep apnoea (OSA). Eighty-six hypertensive patients with apnoea-hypopnoea index ≥25 events/hr and no other cardiovascular, pulmonary, renal, or metabolic disease were randomly assigned to receive allopurinol, losartan, or placebo for 6 weeks...
May 11, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29746310/beneficial-response-of-blood-pressure-to-short-term-continuous-positive-airway-pressure-in-chinese-patients-with-obstructive-sleep-apnea-hypopnea-syndrome
#10
Xiao Wang, Jian Qiu, Yufeng Wang, Zechuan Cai, Xiaoxia Lu, Taoping Li
BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is common in people with hypertension and cardiac rhythm disorder. The objectives of this study were to determine the effect of short-term continuous positive airway pressure (CPAP) on blood pressure (BP) and cardiac rhythm in Chinese patients with moderate to severe OSAHS. PATIENTS AND METHODS: Eligible patients in the two hospitals were consecutively enrolled into the prospective study. Ambulatory BP monitoring and Holter monitoring were both performed for 24 h in 214 patients who previously encountered a full night polysomnography...
May 9, 2018: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29741736/patient-satisfaction-with-sleep-study-experience-findings-from-the-sleep-apnea-patient-centered-outcomes-network
#11
Vishesh K Kapur, James C Johnston, Michael Rueschman, Jessie P Bakker, Lucas M Donovan, Mark Hanson, Zinta Harrington, Jia Weng, Susan Redline
Study Objectives: Home sleep apnea testing (HSAT) is increasingly used as an alternative to laboratory-based polysomnography (PSG) for the diagnosis of obstructive sleep apnea. Patient satisfaction with sleep testing performed at home or in the lab has been sparsely assessed despite its potentially pivotal role in determining patients' acceptance of sleep apnea treatment. We hypothesize that satisfaction in clinical practice may differ from what has been previously reported within the research setting...
May 8, 2018: Sleep
https://www.readbyqxmd.com/read/29734988/change-in-cognition-and-other-non-motor-symptoms-with-obstructive-sleep-apnea-treatment-in-parkinson-disease
#12
Marta Kaminska, Victoria P Mery, Anne-Louise Lafontaine, Ann Robinson, Andrea Benedetti, Priti Gros, R John Kimoff
STUDY OBJECTIVES: Parkinson disease (PD) non-motor symptoms are associated with sleep disorders and impair quality of life. Our objective was to assess the effect of obstructive sleep apnea (OSA) treatment using continuous positive airway pressure (CPAP) on PD non-motor symptoms. METHODS: In this prospective observational study, 67 patients with idiopathic PD underwent polysomnography. Those with moderate-severe OSA were offered CPAP therapy. Subjects were divided into those without OSA (OSA-), and those with OSA (OSA+)...
April 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29731500/sleep-disordered-breathing-a-real-therapeutic-target-for-hypertension-pulmonary-hypertension-ischemic-heart-disease-and-chronic-heart-failure
#13
Takaaki Nakamoto
Sleep-disordered breathing (SDB) is a risk factor for cardiovascular disease including acute coronary syndrome and acute myocardial infarction, and treating SDB prevents their development and recurrence and improves a patient's prognosis. Therefore, SDB is considered a therapeutic target for cardiovascular disease. In 2010, the Japanese Circulation Society published guidelines for the diagnosis and treatment of SDB in patients with cardiovascular disease. However, therapeutic intervention for patients with SDB was recently reported not to suppress the development or deterioration of cardiovascular disease in three middle- to large-sized randomized clinical trials: the SERVE-HF trial, which examined the effects of adaptive servo-ventilation (ASV) on patients with chronic heart failure (CHF) and central sleep apnea; the CAT-HF trial, which examined the effects of ASV therapy on patients with CHF after acute deterioration; and the SAVE study, which examined the secondary preventive effect of continuous positive airway pressure (CPAP) on patients with ischemic heart disease who had mild to moderate obstructive sleep apnea...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29726745/physical-activity-and-exercise-in-obstructive-sleep-apnea
#14
Van Offenwert Evelien, Vrijsen Bart, Belge Catharina, Troosters Thierry, Buyse Bertien, Testelmans Dries
OBJECTIVES: In the last decade significant research has focused on the relationship between physical activity (PA), exercise and obstructive sleep apnea (OSA). The purpose of this study is to provide an overview and interpretation of different studies regarding this subject. METHODS: PubMed, Embase and Cochrane Library databases were searched for English articles published before August 21, 2017. Search terms were 'Sleep Apnea, Obstructive' and 'Exercise'. RESULTS: Low levels of PA are associated with higher odds of OSA...
May 4, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29724113/impact-of-positive-pressure-treatment-of-the-airway-on-health-related-quality-of-life-in-elderly-patients-with-obstructive-sleep-apnea
#15
Jesús Serrano Merino, Luis Ángel Pérula de Torres, Wayne A Bardwell, Rafaela Muñoz Gómez, Ana Roldán Villalobos, Nuria Feu Collado, Roger Ruiz-Moral, Bernabé Jurado-Gámez
BACKGROUND: Obstructive sleep apnea (OSA) is a chronic illness that increases in prevalence with age. Treatment includes continuous positive airway pressure (CPAP) devices. Studies about the use of CPAP in the elderly are scarce. The main objective of this study is to determine whether CPAP contributes to improvement in health-related quality of life (HRQL) in elderly patients with OSA. METHOD: This was a prospective, pre-/postintervention assessment of a cohort of patients ≥65 years of age with OSA diagnosis by polysomnography who were being treated with CPAP and were physically independent and had good cognitive status...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29707357/transvenous-phrenic-nerve-stimulation-a-novel-therapeutic-approach-for-central-sleep-apnea
#16
REVIEW
Ning Ding, Xilong Zhang
Central sleep apnea (CSA) is common in heart failure (HF) patients. Traditional treatment of CSA, including continuous positive airway pressure (CPAP), adaptive servo ventilation (ASV), oxygen therapy, and CO2 inhalation, has respective limitations. Transvenous phrenic nerve stimulation (PNS), a novel therapeutic approach for CSA, was proved to be effective and safe. The remedē® system and related transvenous PNS methods was approved by FDA in 2017, for treating moderate to severe CSA.
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29707350/treatment-choice-by-patients-with-obstructive-sleep-apnea-data-from-two-centers-in-china
#17
Wen-Jing Liao, Li-Juan Song, Hong-Liang Yi, Jian Guan, Jian-Yin Zou, Hua-Jun Xu, Gang Wang, Fei Ma, Li-Bo Zhou, Yu-Qing Chen, Li-Bo Yan, Zhi-Cheng Deng, Walter T McNicholas, Shan-Kai Yin, Nan-Shan Zhong, Xiao-Wen Zhang
Background: Standard management has been recommended for obstructive sleep apnea (OSA) by several guidelines, but patient choice in the practical setting is unclear. Methods: A survey nested in two prospective cohort studies of OSA (enrollment: 2001-2010) in China. The last interview was conducted between July 2014 and May 2015, using a comprehensive 10-point questionnaire administered in a face-to-face or telephone interview, and assessed (I) whether the participant had received any OSA treatment; (II) why he or she had decided for or against treatment; (III) what treatment was received; (IV) whether the participant used continuous positive airway pressure (CPAP) or OA daily; and (V) the perceived efficacy of therapy...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29701312/tidal-breath-eno-measurements-in-a-cohort-of-unsedated-hospitalized-neonates-a-method-validation
#18
Birgitte J Schmidt, Pauline S Reim, Andreas K Jensen, Per Albertsen, Gorm Greisen, Inger M Jørgensen
AIM: Exhaled Nitric oxide (eNO) is an inflammatory marker. In 2002 Hall et al. [J Appl Physiol. 92:59-66] established an infant eNO measurement method, fulfilling four criteria of feasibility: simple, non-invasive, without impact on the natural breathing pattern, and accounting for flow by NO output (V'NO). Although tidal breathing is accepted as an eNO measurement method in uncooperative patients, it is seldom used outside research labs. The variability and lack of validated methods have restrained from exploring the area in preterm and term neonates the last years...
April 27, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29698721/fixed-but-not-autoadjusting-positive-airway-pressure-attenuates-the-time-dependent-decline-in-glomerular-filtration-rate-in-patients-with-obstructive-sleep-apnea
#19
Oreste Marrone, Fabio Cibella, Jean-Louis Pépin, Ludger Grote, Johan Verbraecken, Tarja Saaresranta, John A Kvamme, Ozen K Basoglu, Carolina Lombardi, Walter T McNicholas, Jan Hedner, Maria R Bonsignore
BACKGROUND: The impact of treating obstructive sleep apnea (OSA) on renal function decline is controversial. Previous studies usually included small samples and did not consider specific effects of different continuous positive airway pressure (CPAP) modalities. The aim of this study was to evaluate the respective influence of fixed and auto-adjusting CPAP modes on estimated glomerular filtration rate (eGFR) in a large sample of patients derived from the prospective European Sleep Apnea Database (ESADA) cohort...
April 23, 2018: Chest
https://www.readbyqxmd.com/read/29695760/association-between-obstructive-sleep-apnea-and-optic-neuropathy-a-taiwanese-population-based-cohort-study
#20
Ming-Hui Sun, Yaping Joyce Liao, Che-Chen Lin, Rayleigh Ping-Ying Chiang, James Cheng-Chung Wei
PURPOSE: Obstructive sleep apnea (OSA) is associated with many systemic diseases including diabetes, hypertension, stroke, and cardiovascular disease. The aim of our study was to investigate the association between OSA and optic neuropathy (ON), and to evaluate the efficacy of treatment for OSA on the risk of ON. METHODS: We used the data from the Longitudinal Health Insurance Database, which involved one million insurants from Taiwan National Health Insurance program (Taiwan NHI)...
April 26, 2018: Eye
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