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https://www.readbyqxmd.com/read/28101940/chronic-nasal-exposure-to-nanoparticulate-tio2-causes-pulmonary-tumorigenesis-in-male-mice
#1
Fashui Hong, Li Ji, Yingjun Zhou, Ling Wang
Chronic inhalation bioassays in rodents are used to assess pulmonary carcinogenicity for purposes of hazard identification and potentially for risk characterization. Numerous studies have been confirmed that exposure to titanium dioxide nanoparticles (TiO2 NPs) may result in chronic pulmonary inflammation in both mice and rats. However, very few studies have focused on the pulmonary tumorigenesis. In this study, to examine whether chronic TiO2 NP exposure induce tumorigenesis in the lung, forty mice (each group) were nasally exposed to 1...
January 19, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28100873/microrna-10a-targets-t-box-5-to-inhibit-the-development-of-cardiac-hypertrophy
#2
Dan Wang, Guanqun Zhai, Yangfei Ji, Haiyun Jing
The mechanism of cardiac hypertrophy involving microRNAs (miRNAs) is attracting increasing attention. Our study aimed to investigate the role of miR-10a in cardiac hypertrophy development and the underlying regulatory mechanism.Transverse abdominal aortic constriction (TAAC) surgery was performed to establish a cardiac hypertrophy rat model, and angiotensin II (AngII) was used to induce cardiac hypertrophy in cultured neonatal rat cardiomyocytes. Expression of T-box 5 (TBX5) and miR-10a was altered by cell transfection of siRNA or miRNA mimic/inhibitor...
January 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28098903/vitexin-alleviates-lipopolysaccharide%C3%A2-induced-islet-cell-injury-by-inhibiting-hmgb1-release
#3
Feifei Wang, Jiajing Yin, Yujin Ma, Hongwei Jiang, Yanbo Li
Diabetes mellitus (DM) is a chronic metabolic disease, where the predominant pathogenesis is pancreatic β‑cells dysfunction or injury. It has been well established that inflammation leads to a gradual exhaustion of pancreatic β‑cell function with decreased β‑cell mass likely resulting from pancreatic β‑cells apoptosis or death. Vitexin, a major bioactive flavonoid compound in plants has numerous pharmacological properties, including antioxidant, anti‑inflammatory and antimyeloperoxidase. Whether vitexin can protect pancreatic β‑cells against lipopolysaccharide (LPS)‑induced pro‑inflammatory cytokine production and apoptosis has received little attention...
January 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28098886/novel-zinc-phthalocyanine-as-a-promising-photosensitizer-for-photodynamic-treatment-of-esophageal-cancer
#4
Weronika Kuzyniak, Jacob Schmidt, Wojciech Glac, Janine Berkholz, Gustav Steinemann, Björn Hoffmann, Eugeny A Ermilov, Ayşe Gül Gürek, Vefa Ahsen, Bianca Nitzsche, Michael Höpfner
Photodynamic therapy (PDT) has gathered much attention in the field of cancer treatment and is increasingly used as an alternative solution for esophageal cancer therapy. However, there is a constant need for improving the effectiveness and tolerability of the applied photosensitizers (PS). Here, we propose tetra-triethyleneoxysulfonyl substituted zinc phthalocyanine (ZnPc) as a promising PS for photodynamic treatment of esophageal cancer. ZnPc-induced phototoxicity was studied in two human esophageal cancer cell lines: OE-33 (adenocarcinoma) and Kyse-140 (squamous cell carcinoma)...
January 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28096966/microrna-297a-regulates-vascular-calcification-by-targeting-fibroblast-growth-factor-23
#5
Shouhua Zheng, Shuijun Zhang, Yan Song, Wenzhi Guo, Wenlong Zhai, Xinguang Qiu, Jianhua Li
OBJECTIVES: Vascular calcification is one the major characteristics in patients with various types of chronic inflammatory disorders. MiRNAs have been shown to be involved in many normal biological functions as well as diseases; however, their role in vascular calcification has not received much attention. MATERIALS AND METHODS: In the current study, we built a vascular calcification rat model using vitamin D3 plus nicotine and analyzed miRNA expression profile by miRNA chip assay...
December 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28095515/effects-of-ultraviolet-photofunctionalization-on-bone-augmentation-and-integration-capabilities-of-titanium-mesh-and-implants
#6
Makoto Hirota, Takayuki Ikeda, Masako Tabuchi, Tomomichi Ozawa, Iwai Tohnai, Takahiro Ogawa
PURPOSE: Ultraviolet (UV)-mediated photofunctionalization has earned considerable attention for the enhancement of the biologic capabilities of titanium. The effects of photofunctionalization on bone augmentation and gap closure were examined using titanium implants and mesh in a rat femur model. MATERIALS AND METHODS: An acid-etched titanium implant (4-mm length, 1-mm diameter) was placed in the gluteal tuberosity that resembles a knife-edge-like edentulous ridge...
January 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28093027/effects-of-amphetamine-and-methylphenidate-on-attentional-performance-and-impulsivity-in-the-mouse-5-choice-serial-reaction-time-task
#7
Maitane Caballero-Puntiverio, Ciarán Martin Fitzpatrick, David Pd Woldbye, Jesper Tobias Andreasen
BACKGROUND: Few studies have investigated the effects of conventional attention deficit-hyperactivity disorder (ADHD) medication in the mouse 5-choice serial reaction time task (5-CSRTT), and rat studies have yielded inconsistent results. OBJECTIVE: We aimed to examine the effects of acute methylphenidate (MPH) and amphetamine (AMPH) treatment in the mouse 5-CSRTT. METHODS: Trained male C57Bl/6J mice were tested in a variable stimulus duration schedule...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28092808/antinociceptive-effect-of-co-administered-nmda-and-histamine-h4-receptor-antagonists-in-a-rat-model-of-acute-pain
#8
Renata Wolińska, Anna Leśniak, Małgorzata Żochowska, Mariusz Sacharczuk, Katarzyna Kieć-Kononowicz, Magdalena Bujalska-Zadrożny
BACKGROUND: The histamine H4 receptor (H4R) has attracted a lot of attention in terms of its role in antinociception. The N-Methyl-d-aspartic acid (NMDA) receptor is a well-characterized participant in pain pathways. However, it's influence on H4R signaling is poorly understood. Thus, in the present study we investigated the effect of a selective H4R antagonist JNJ7777120 (25mg/kg) and a NMDA receptor antagonist MK-801 (0.1-10μg) on nociceptive thresholds in a rat acute pain model. METHODS: The influence of intrathecally (it), intracerebroventricularly (icv) and intraplantarly (ipl) administered MK-801 co-injected with JNJ7777120 administered intraperitoneally (ip) was determined in the modified Randall-Selitto paw pressure, the tail flick and plantar tests...
October 29, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28092205/effect-of-polidocanol-foam-administration-into-rat-peripheral-veins-on-pulmonary-parenchyma
#9
Melissa A de Moraes Silva, Rimarcs G Ferreira, Seleno G de Jesus-Silva, Rodolfo S Cardoso, Fausto Miranda
Background Sclerotherapy has been gaining increased acceptance and popularity as an effective therapy for the treatment of varicose veins. This attention has fed growing interest into the safety and potential complications of this procedure. There is no evidence of pulmonary complications from foam sclerotherapy in humans; however, animal studies have shown possible damage. The aim of this study is to show the changes in rat pulmonary parenchyma after the injection of 1% polidocanol Tessari foam into the peripheral vein using histological analysis of the inflammatory and fibrosis processes...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/28089853/region-specific-increases-in-fosb-%C3%AE-fosb-immunoreactivity-in-the-rat-brain-in-response-to-chronic-sleep-restriction
#10
Shannon Hall, Samüel Deurveilher, Kristin Robin Ko, Joan Burns, Kazue Semba
Using a rat model of chronic sleep restriction (CSR) featuring periodic sleep deprivation with slowly rotating wheels (3h on/1h off), we previously observed that 99h of this protocol induced both homeostatic and allostatic (adaptive) changes in physiological and behavioural measures. Notably, the initial changes in sleep intensity and attention performance gradually adapted during CSR despite accumulating sleep loss. To identify brain regions involved in these responses, we used FosB/ΔFosB immunohistochemistry as a marker of chronic neuronal activation...
January 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28089663/phase-dependent-activity-of-neurons-in-the-rostral-part-of-the-thalamic-reticular-nucleus-with-saccharin-intake-in-a-cue-guided-lever-manipulation-task
#11
Ryuhei Aoki, Risako Kato, Satoshi Fujita, Jun Shimada, Noriaki Koshikawa, Masayuki Kobayashi
Neurons in the rostral part of the thalamic reticular nucleus (rTRN) receive somatosensory and motor information and regulate neural activities of the thalamic nuclei. Previous studies showed that when activity in visual TRN neurons is suppressed prior to the visual stimuli in a visual detection task, the performance of the task improves. However, little is known about such changes in the rTRN preceding certain events. In the present study, we performed unit recordings in the rTRN in alert rats during a cue-guided lever-manipulation task in which saccharin was provided as a reward...
January 12, 2017: Brain Research
https://www.readbyqxmd.com/read/28087442/hydrogen-sulfide-protects-against-endoplasmic-reticulum-stress-and-mitochondrial-injury-in-nucleus-pulposus-cells-and-ameliorates-intervertebral-disc-degeneration
#12
Daoliang Xu, Haiming Jin, Jianxia Wen, Jiaoxiang Chen, Deheng Chen, Ningyu Cai, Yongli Wang, Jianle Wang, Yu Chen, Xiaolei Zhang, Xiangyang Wang
It has been suggested that excessive apoptosis in intervertebral disc cells induced by inflammatory cytokines, such as interleukin (IL)-1β, is related to the process of intervertebral disc degeneration (IVDD). Hydrogen sulfide (H2S), a gaseous signaling molecule, has drawn attention for its anti-apoptosis role in various pathophysiological processes in degenerative diseases. To date, there has been no investigation of the correlation of H2S production and IVDD or of the effects of H2S on IL-1β-induced apoptosis in nucleus pulposus (NP) cells...
January 10, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28087334/the-short-and-long-term-proteomic-effects-of-sleep-deprivation-on-the-cortical-and-thalamic-synapses
#13
Attila Simor, Balázs András Györffy, Péter Gulyássy, Katalin Völgyi, Vilmos Tóth, Mihail Ivilinov Todorov, Viktor Kis, Zsolt Borhegyi, Zoltán Szabó, Tamás Janáky, László Drahos, Gábor Juhász, Katalin Adrienna Kékesi
Acute total sleep deprivation (SD) impairs memory consolidation, attention, working memory and perception. Structural, electrophysiological and molecular experimental approaches provided evidences for the involvement of sleep in synaptic functions. Despite the wide scientific interest on the effects of sleep on the synapse, there is a lack of systematic investigation of sleep-related changes in the synaptic proteome. We isolated parietal cortical and thalamic synaptosomes of rats after 8 h of total SD by gentle handling and 16 h after the end of deprivation to investigate the short- and longer-term effects of SD on the synaptic proteome, respectively...
January 10, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28087265/myocardial-relaxation-is-accelerated-by-fast-stretch-not-reduced-afterload
#14
Charles S Chung, Charles W Hoopes, Kenneth S Campbell
Fast relaxation of cross-bridge generated force in the myocardium facilitates efficient diastolic function. Recently published research studying mechanisms that modulate the relaxation rate has focused on molecular factors. Mechanical factors have received less attention since the 1980s when seminal work established the theory that reducing afterload accelerates the relaxation rate. Clinical trials using afterload reducing drugs, partially based on this theory, have thus far failed to improve outcomes for patients with diastolic dysfunction...
January 10, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28087221/varenicline-provokes-impulsive-action-by-stimulating-%C3%AE-4%C3%AE-2-nicotinic-acetylcholine-receptors-in-the-infralimbic-cortex-in-a-nicotine-exposure-status-dependent-manner
#15
Yu Ohmura, Hitomi Sasamori, Iku Tsutsui-Kimura, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshioka
Higher impulsivity is a risk factor for criminal involvement and drug addiction. Because nicotine administration enhances impulsivity, the effects of stop-smoking aids stimulating nicotinic acetylcholine receptors (nAChRs) on impulsivity must be determined in different conditions. Our goals were 1) to confirm the relationship between varenicline, a stop-smoking aid and α4β2 nAChR partial agonist, and impulsivity, 2) to elucidate the mechanisms underlying the effects of varenicline, 3) to examine whether a low dose of varenicline that does not evoke impulsive action could block the stimulating effects of nicotine on impulsive action, 4) to determine whether the route of administration could modulate the effects of varenicline on impulsive action, and 5) to determine whether the effects of varenicline on impulsivity could be altered by smoking status...
January 10, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28087055/graft-modification-of-cotton-with-phosphate-group-and-its-application-to-the-enrichment-of-phosphopeptides
#16
Xiao-Mei He, Xi Chen, Bi-Feng Yuan, Yu-Qi Feng
Grafting copolymerization, especially "grafting from" approach, has attracted a great attention for the preparation of cellulose-based materials with various functionalities. In this study, a novel phosphate group-containing cotton fiber-based material, CF-NH2-AZO-p(VPA-x), was successfully synthesized by a "grafting from" radical polymerization approach using vinyl phosphonic acid (VPA) as monomer. The phosphate group content of CF-NH2-AZO-p(VPA-x) could be easily regulated by adjusting the concentration of VPA monomer...
January 9, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28071664/comparison-of-the-glycopattern-alterations-of-mitochondrial-proteins-in-cerebral-cortex-between-rat-alzheimer-s-disease-and-the-cerebral-ischemia-model
#17
Houyou Yu, Changwei Yang, Shi Chen, Yang Huang, Chuanming Liu, Jian Liu, Wen Yin
Alzheimer's disease (AD) and ischemic brain injury are two major neurodegenerative diseases. Mitochondrial dysfunction commonly occurs in AD and ischemic brain injury. Currently, little attention has been paid to the glycans on mitochondrial glycoproteins, which may play vital roles during the process of mitochondrial dysfunction. The aim of this study was to illustrate and compare the glycopattern alterations of mitochondrial glycoproteins extracted from the cerebral cortex of the rat models of these two diseases using High-throughput lectin microarrays...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28070499/metabolic-relationship-between-diabetes-and-alzheimer-s-disease-affected-by-cyclo-his-pro-plus-zinc-treatment
#18
REVIEW
Moon K Song, David S Bischoff, Albert M Song, Koichi Uyemura, Dean T Yamaguchi
BACKGROUND: Association of Alzheimer's Disease (AD) with Type 2 Diabetes (T2D) has been well established. Cyclo(His-Pro) plus zinc (Cyclo-Z) treatment ameliorated diabetes in rats and similar improvements have been seen in human patients. Treatment of amyloid precursor protein (APP) transgenic mice with Cyclo-Z exhibited memory improvements and significantly reduced Aβ-40 and Aβ-42 protein levels in the brain tissues of the mice. SCOPE OF REVIEW: Metabolic relationship between AD and T2D will be described with particular attention to insulin sensitivity and Aβ degradation in brain and plasma tissues...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28069927/impact-of-altered-cholinergic-tones-on-the-neurovascular-coupling-response-to-whisker-stimulation
#19
Clotilde Lecrux, Claire H Sandoe, Sujaya Neupane, Pascal Kropf, Xavier Toussay, Xin-Kang Tong, María Lacalle-Aurioles, Amir Shmuel, Edith Hamel
Brain imaging techniques that use vascular signals to map changes in neuronal activity rely on the coupling between electrophysiology and hemodynamics, a phenomenon referred to "neurovascular coupling" (NVC). It is unknown whether this relationship remains reliable under altered brain states associated to acetylcholine (ACh) levels, such as attention and arousal, and in pathological conditions like Alzheimer's disease. We therefore assessed the effects of varying ACh tone on whisker evoked-NVC responses in rat barrel cortex, measured by cerebral blood flow (CBF) and neurophysiological recordings (local field potentials, LFPs)...
January 9, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28069460/epilepsy-and-exercise-an-experimental-study-in-female-rats
#20
Diego Vannucci Campos, Glauber Menezes Lopim, Daiana Aparecida da Silva, Alexandre Aparecido de Almeida, Debora Amado, Ricardo Mario Arida
OBJECTIVE: Epilepsy is the most common neurological chronic condition worldwide, affecting about 2% of world population. Temporal lobe epilepsy (TLE) reaches 40% of all cases of this condition, and it is highly refractory to pharmacological treatment. Physical activity has been suggested as complementary therapy for epilepsy. However, there is no consistent information whether all these effects are plenty applicable to females, since clinical and experimental studies concerning physical exercise and epilepsy are largely performed in males...
January 6, 2017: Physiology & Behavior
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