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https://www.readbyqxmd.com/read/27919728/voluntary-running-improves-depressive-behaviours-and-the-structure-of-the-hippocampus-in-rats-a-possible-impact-of-myokines
#1
Magda A Eldomiaty, Shaima M Almasry, Maha K Desouky, Sami A Algaidi
This study investigated the impact of voluntary exercise on depressive behaviours, serum and hippocampal levels of myokines, and histopathological features of hippocampal formation in rats. Depressed rats were allowed to voluntarily run on a wheel for 3 weeks. Locomotor activity was assessed by a forced swimming test and the myokine levels in sera and hippocampal homogenates were measured using Enzyme-linked Immunosorbent Assay. Brain sections were analysed for hippocampal structure and neuronal counts. Voluntary running produced significant increase in the distance moved by rats and significant decrease in immobility duration...
December 2, 2016: Brain Research
https://www.readbyqxmd.com/read/27919700/exposure-to-sevoflurane-anesthesia-during-development-does-not-impair-aspects-of-attention-during-adulthood-in-rats
#2
Kathy L Murphy, Jill McGaughy, Paula L Croxson, Mark G Baxter
Exposure to general anesthetic agents during development has been associated with neurotoxicity and long-term behavioral impairments in rodents and non-human primates. The phenotype of anesthetic-induced cognitive impairment has a robust learning and memory component, however less is known about other psychological domains. Data from retrospective human patient studies suggest that children undergoing multiple procedures requiring general anesthesia are at increased risk of attention deficit hyperactivity disorder...
December 2, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27917436/looking-ahead-where-to-next-for-animal-models-of-bronchopulmonary-dysplasia
#3
REVIEW
Claudio Nardiello, Ivana Mižíková, Rory E Morty
Bronchopulmonary dysplasia (BPD) is the most common complication of preterm birth, with appreciable morbidity and mortality in a neonatal intensive care setting. Much interest has been shown in the identification of pathogenic pathways that are amenable to pharmacological manipulation (1) to facilitate the development of novel therapeutic and medical management strategies and (2) to identify the basic mechanisms of late lung development, which remains poorly understood. A number of animal models have therefore been developed and continue to be refined with the aim of recapitulating pathological pulmonary hallmarks noted in lungs from neonates with BPD...
December 5, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27917122/glucagon-like-peptide-1-analog-liraglutide-delays-onset-of-experimental-autoimmune-encephalitis-in-lewis-rats
#4
Brian DellaValle, Gitte S Brix, Birgitte Brock, Michael Gejl, Anne M Landau, Arne Møller, Jørgen Rungby, Agnete Larsen
Introduction: Recent findings indicate that metabolic disturbances are involved in multiple sclerosis (MS) pathology and influence the susceptibility to treatment, directing attention toward anti-diabetic drugs such as metformin and pioglitazone. Liraglutide, a drug of the glucagon-like peptide-1 (GLP-1) family, is also anti-diabetic and weight-reducing and is, moreover, directly neuroprotective and anti-inflammatory in a broad spectrum of experimental models of brain disease. In this study we investigate the potential for this FDA-approved drug, liraglutide, as a treatment for MS by utilizing the experimental model, experimental autoimmune encephalitis (EAE)...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27916115/highly-sensitive-and-specific-derivatization-strategy-to-profile-and-quantitate-eicosanoids-by-uplc-ms-ms
#5
Ting Hu, Cai Tie, Zhe Wang, Jin-Lan Zhang
Eicosanoids are signaling molecules mainly oxidized from arachidonic acid (ARA) and eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). They have attracted increasing attention from the scientists attributing to their essential physiological functions. However, their quantification have long been challenged by the low abundance, high structure similarity, poor stability and limited ionization efficiency. In this paper, an ultra-high performance liquid chromatograph coupled with tandem mass spectrometry (UPLC-MS/MS) strategy was developed for the comprehensive profiling of more than 60 eicosanoids based on an efficient derivatization reagent 2,4-bis(diethylamino)-6-hydrazino-1,3,5-triazine (T3) and general multiple reaction monitoring (MRM) parameters...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27892655/3d-printed-polycaprolactone-carbon-nanotube-composite-scaffolds-for-cardiac-tissue-engineering
#6
Chee Meng Benjamin Ho, Abhinay Mishra, Pearlyn Teo Pei Lin, Sum Huan Ng, Wai Yee Yeong, Young-Jin Kim, Yong-Jin Yoon
Fabrication of tissue engineering scaffolds with the use of novel 3D printing has gained lot of attention, however systematic investigation of biomaterials for 3D printing have not been widely explored. In this report, well-defined structures of polycaprolactone (PCL) and PCL- carbon nanotube (PCL-CNT) composite scaffolds have been designed and fabricated using a 3D printer. Conditions for 3D printing has been optimized while the effects of varying CNT percentages with PCL matrix on the thermal, mechanical and biological properties of the printed scaffolds are studied...
November 28, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27892654/injectable-polysaccharide-hydrogels-as-biocompatible-platforms-for-localized-and-sustained-delivery-of-antibiotics-for-preventing-local-infections
#7
Ziyi Li, Chaoliang He, Baoming Yuan, Xiaoming Dong, Xuesi Chen
Biocompatible and antibacterial hydrogels have received increasing attention for preventing local bacterial infections. In this study, a type of polysaccharide hydrogels is prepared via the Schiff-based reaction at physiological conditions. The gelation time and mechanical property of the hydrogels are found to be dependent on the polysaccharide concentration and the polysaccharide weight ratio. 3-(4,5-Dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay and live/dead assay indicate that the hydrogels display nontoxicity in vitro...
November 28, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27890441/the-ability-for-cocaine-and-cocaine-associated-cues-to-compete-for-attention
#8
Kyle K Pitchers, Taylor R Wood, Cari J Skrzynski, Terry E Robinson, Martin Sarter
In humans, reward cues, including drug cues in addicts, are especially effective in biasing attention towards them, so much so they can disrupt ongoing task performance. It is not known, however, whether this happens in rats. To address this question, we developed a behavioral paradigm to assess the capacity of an auditory drug (cocaine) cue to evoke cocaine-seeking behavior, thus distracting thirsty rats from performing a well-learned sustained attention task (SAT) to obtain a water reward. First, it was determined that an auditory cocaine cue (tone-CS) reinstated drug-seeking equally in sign-trackers (STs) and goal-trackers (GTs), which otherwise vary in the propensity to attribute incentive salience to a localizable drug cue...
November 24, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27889580/methylphenidate-modulates-dorsal-raphe-neuronal-activity-behavioral-and-neuronal-recordings-from-adolescent-rats
#9
Holly Whitt, Natasha Kharas, Nachum Dafny, Cruz Reyes-Vasquez
Methylphenidate (MPD) is a widely prescribed psychostimulants used for the treatment of attention deficit hyperactive disorder (ADHD). Unlike the psychostimulants cocaine and amphetamine, MPD does not exhibit direct actions on the serotonin transporter, however there is evidence suggesting that the therapeutic effects of MPD may be mediated in part by alterations in serotonin transmission. This study aimed to investigate the role of the dorsal raphe (DR) nucleus, one of the major sources of serotonergic innervation in the mammalian brain, in the response to MPD exposure...
November 23, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27886572/a-rapid-and-sensitive-uhplc-ms-ms-method-for-quantification-of-83b1-in-plasma-and-its-application-to-bioavailability-study-in-rats
#10
Dingsheng Wen, Jing Guo, Fulin Jiang, Caishun Huang, Zhenzhen Zhao, Gui Lu, Jiangying Chen, Liuyun Qin, Zhangwei Li, Xueding Wang, Zhuoan Deng, Min Huang, Chan Albert Sun Chi, Tang Johnny Cheuk On, Guoping Zhong
Great attentions have been drawn by quinoline for its broad bioactivity as anti-fungal, anti-bacterial and anti-tumor activities. Compared with cisplatin, 83b1, a quinoline derivative, showed equal activity in anti-tumor and lower cyctotoxicity in normal cell. In this study, a simple, rapid and sensitive method for determination of 83b1 in rat plasma using UHPLC-MS/MS was developed for the first time. Loratadine was used as an internal standard (IS). Separation was performed on an Xterra MS C18 column by isocratic elution using acetonitrile: water solution with 1‰ formic acid (90:10, v/v) as mobile phase at a flow rate of 0...
November 16, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27884426/preparation-and-application-of-immobilized-enzymatic-reactors-for-consecutive-digestion-with-two-enzymes
#11
Bingbing Wang, Lulu Shangguan, Shulei Wang, Lingyi Zhang, Weibing Zhang, Fan Liu
The bottom up strategy has drawn much attention due to the high accuracy, reliability, and reproducibility in protein identification in which proteins are digested into peptides. However, conventional solution-based digestion and enzymatic reactor with one protease immobilized cannot satisfy high throughput proteolysis of complex samples. Application of consecutive hydrolysis by enzymatic reactor can be a new strategy for high throughput proteolysis of complex samples by adjusting immobilization amount of the enzymes, enzyme ratio, as well as hydrolysis order of two enzymes...
November 18, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27876560/subcutaneous-rotenone-rat-model-of-parkinson-s-disease-dose-exploration-study
#12
Zhen-Nian Zhang, Jing-Si Zhang, Jun Xiang, Zhong-Hai Yu, Wen Zhang, Min Cai, Xiang-Ting Li, Ting Wu, Wen-Wei Li, Ding-Fang Cai
Subcutaneous administration of rotenone has recently attracted attention because of its convenience, simplicity and efficacy in replicating features of Parkinson's disease (PD) in animal models. However, the wide range of doses reported in the literature makes it difficult to evaluate the effectiveness of this technique objectively. The aim of the present study was to identify the optimum dose of subcutaneous rotenone for establishing a model of PD. We injected male Wistar rats subcutaneously with one of three doses of rotenone (1...
November 19, 2016: Brain Research
https://www.readbyqxmd.com/read/27870416/sex-specific-mechanisms-for-responding-to-stress
#13
REVIEW
Debra A Bangasser, Brittany Wicks
Posttraumatic stress disorder and major depression share stress as an etiological contributor and are more common in women than in men. Traditionally, preclinical studies investigating the neurobiological underpinnings of stress vulnerability have used only male rodents; however, recent studies that include females are finding sex-specific mechanisms for responding to stress. This Mini-Review examines recent literature using a framework developed by McCarthy and colleagues (2012; J Neurosci 32:2241-2247) that highlights different types of sex differences...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27866122/synthesis-characterization-and-radiolabeling-of-folic-acid-modified-nanostructured-lipid-carriers-as-a-contrast-agent-and-drug-delivery-system
#14
Eser Ucar, Serap Teksoz, Cigdem Ichedef, Ayfer Yurt Kilcar, E Ilker Medine, Kadir Ari, Yasemin Parlak, B Elvan Sayit Bilgin, Perihan Unak
Nanostructured lipid carriers (NLCs) are the new generation of solid lipid drug delivery systems. Their suitability as contrast agents for gamma scintigraphy is an attracting major attention. The aim of current study was to prepare surface modified nanostructured lipid carrier system for paclitaxel (PTX) with active targeting and imaging functions. In accordance with the purpose of study, PTX loaded nanostructured lipid carriers (NLCs) prepared, modified with a folate derivative and radiolabeled with technetium-99m tricarbonyl complex ((99m)Tc(CO)3(+))...
January 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27866083/neuroanatomical-differences-in-fast-and-slow-rat-strains-with-differential-vulnerability-to-kindling-and-behavioral-comorbidities
#15
Pragati Sharma, Stefanie Dedeurwaerdere, Michael A D Vandenberg, Ke Fang, Leigh A Johnston, Sandy R Shultz, Terence J O'Brien, Krista L Gilby
OBJECTIVE: The neurobiological factors underlying a predisposition towards developing epilepsy and its common behavioral comorbidities are poorly understood. FAST rats are a strain that has been selectively bred for enhanced vulnerability to kindling, while the SLOW strain has been bred to be resistant to kindling. FAST rats also exhibit behavioral traits reminiscent of those observed in neurodevelopmental disorders (autism spectrum disorder (ASD)/attention-deficit/hyperactivity disorder (ADHD)) commonly comorbid with epilepsy...
November 17, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27865067/laminin-modified-and-aligned-phbv-peo-nanofibrous-nerve-conduits-promote-peripheral-nerve-regeneration
#16
Xiao-Feng Zhang, Hai-Xia Liu, Lazarus Santiago Ortiz, Zhong-Dang Xiao, Ning-Ping Huang
Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) has received much attention for its biodegradability and biocompatibility, characteristics which are required in tissue engineering. In this study, polyethylene oxide (PEO)-incorporated PHBV nanofibers with random or aligned orientation were obtained by electrospinning. For further use in vivo, the nanofiber films were made into nerve conduits after treated with NH3 plasma, which could improve the hydrophilicity of inner surfaces of nerve conduits and then facilitate laminin adsorption via electrostatic interaction for promoting cell adhesion and proliferation...
November 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27864066/stimulus-control-in-two-rodent-models-of-attention-deficit-hyperactivity-disorder
#17
Adam E Fox, Sierra R Caramia, Molly M Haskell, Aerial L Ramey, Depika Singha
The spontaneously hypertensive (SHR/NCrl) rat from Charles River is one of the most widely used models of the combined subtype of Attention-Deficit/Hyperactivity Disorder (ADHD-C). Although often used as its control strain, the Wistar Kyoto (WKY/NCrl) from Charles River has been proposed as a model of the predominately inattentive subtype of ADHD (ADHD-PI). In Experiment 1 SHR/NCrl, WKY/NCrl, and Wistar (WI; the progenitor strain for the two models) rats were trained on a left→right lever-press sequence in the presence of light discriminative stimuli that signaled the active lever in the sequence...
November 15, 2016: Behavioural Processes
https://www.readbyqxmd.com/read/27856965/hedgehog-pathway-mediated-vascular-alterations-following-trigeminal-nerve-injury
#18
N Moreau, W Dieb, A Mauborgne, S Bourgoin, L Villanueva, M Pohl, Y Boucher
Whereas neurovascular interactions in spinal neuropathic pain models have been well characterized, little attention has been given to such neurovascular interactions in orofacial neuropathic pain models. This study investigated in male Sprague-Dawley rats the vascular changes following chronic constriction injury (CCI) of the infraorbital nerve (IoN), a broadly validated preclinical model of orofacial neuropathic pain. Following IoN-CCI, an early downregulation of tight junction proteins Claudin-1 and Claudin-5 was observed within the endoneurium and perineurium, associated with increased local accumulation of sodium fluorescein (NaFlu) within the IoN parenchyma, as compared with sham animals...
November 16, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27856160/anti-excitotoxic-effects-of-cannabidiol-are-partly-mediated-by-enhancement-of-ncx2-and-ncx3-expression-in-animal-model-of-cerebral-ischemia
#19
Sepideh Khaksar, Mohammad Reza Bigdeli
Excitotoxicity and imbalance of sodium and calcium homeostasis trigger pathophysiologic processes in cerebral ischemia which can accelerate neuronal death. Neuroprotective role of cannabidiol (CBD), one of the main non-psychoactive phytocannabinoids of the cannabis plant, has attracted attention of many researchers in the neurodegenerative diseases studies. The present investigation was designed to determine whether cannabidiol can alleviate the severity of ischemic damages and if it is able to exert its anti-excitotoxic effects through sodium and calcium regulation...
November 14, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27853928/d1-and-d2-specific-dopamine-antagonist-modulate-the-caudate-nucleus-neuronal-responses-to-chronic-methylphenidate-exposure
#20
Sidish Venkataraman, Catherine Claussen, Nachum Dafny
The psychostimulant, methylphenidate (MPD), is the first line treatment as a pharmacotherapy to treat behavioral disorders such as attention deficit hyperactivity disorder (ADHD). MPD is commonly misused in non-ADHD (normal) youth and young adults both as a recreational drug and for cognitive enhancing effects to improve their grades. MPD is known to act on the reward circuit; including the caudate nucleus (CN). The CN is comprised of medium spiny neurons containing largely dopamine (DA) D1 and D2 receptors...
November 16, 2016: Journal of Neural Transmission
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