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Cancer thermal therapy nano

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https://www.readbyqxmd.com/read/28496166/measurement-of-local-temperature-increments-induced-by-cultured-hepg2-cells-with-micro-thermocouples-in-a-thermally-stabilized-system
#1
Fan Yang, Gang Li, Jiamin Yang, Zhenhai Wang, Danhong Han, Fengjie Zheng, Shengyong Xu
To monitor the temperature distribution of a cell and its changes under varied conditions is currently a technical challenge. A variety of non-contact methods used for measuring cellular temperature have been developed, where changes of local temperature at cell-level and sub-cell-level are indirectly calculated through the changes in intensity, band-shape, bandwidth, lifetime or polarization anisotropy of the fluorescence spectra recorded from the nano-sized fluorescent materials pre-injected into the target cell...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28490761/nanoscale-brownian-heating-by-interacting-magnetic-dipolar-particles
#2
Yann Chalopin, Jean-Claude Bacri, Florence Gazeau, Martin Devaud
Clusters of magnetic nanoparticles have received considerable interest in various research fields. Their capacity to generate heat under an alternating magnetic field has recently opened the way to applications such as cancer therapy by hyperthermia. This work is an attempt to investigate the collective effects of interacting dipoles embedded in magnetic nano-particles (MNP) to predict their thermal dissipation with a liquid. We first present a general approach, based on the tracking of the microscopic dipole fluctuations, to access to the dissipation spectra of any spatial distribution of MNPs...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28476039/nano-pulse-stimulation-nps-ablates-tumors-and-inhibits-lung-metastasis-on-both-canine-spontaneous-osteosarcoma-and-murine-transplanted-hepatocellular-carcinoma-with-high-metastatic-potential
#3
Xinhua Chen, Yiling Chen, Jianwen Jiang, Liming Wu, Shengyong Yin, Xudong Miao, R James Swanson, Shusen Zheng
BACKGROUND: Nanosecond pulsed electric field (nsPEF), which is also termed as nano-pulse stimulation (NPS), has the potential of stimulating immune responses toward cancer cells. The current study investigates its local and systemic antitumor efficacy in vivo in late stage tumors with lung metastasis. METHOD: The 12 canines with spontaneous osteosarcomas and 12 nude mice transplanted with human hepatocellular carcinoma were divided randomly and were given NPS treatment, surgery or no treatment control...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28452928/near-infrared-fluorescence-imaging-in-nano-therapeutics-and-photo-thermal-evaluation
#4
REVIEW
Mukti Vats, Sumit Kumar Mishra, Mahdieh Shojaei Baghini, Deepak S Chauhan, Rohit Srivastava, Abhijit De
The unresolved and paramount challenge in bio-imaging and targeted therapy is to clearly define and demarcate the physical margins of tumor tissue. The ability to outline the healthy vital tissues to be carefully navigated with transection while an intraoperative surgery procedure is performed sets up a necessary and under-researched goal. To achieve the aforementioned objectives, there is a need to optimize design considerations in order to not only obtain an effective imaging agent but to also achieve attributes like favorable water solubility, biocompatibility, high molecular brightness, and a tissue specific targeting approach...
April 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28428881/nano-pulse-stimulation-is-a-physical-modality-that-can-trigger-immunogenic-tumor-cell-death
#5
Richard Nuccitelli, Amanda McDaniel, Snjezana Anand, John Cha, Zachary Mallon, Jon Casey Berridge, Darrin Uecker
BACKGROUND: We have been developing a non-thermal, drug-free tumor therapy called Nano-Pulse Stimulation (NPS) that delivers ultrashort electric pulses to tumor cells which eliminates the tumor and inhibits secondary tumor growth. We hypothesized that the mechanism for inhibiting secondary tumor growth involves stimulating an adaptive immune response via an immunogenic form of apoptosis, commonly known as immunogenic cell death (ICD). ICD is characterized by the emission of danger-associated molecular patterns (DAMPs) that serve to recruit immune cells to the site of the tumor...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28356042/recent-advances-in-oncological-submissions-of-dendrimer
#6
Namrata Soni, Muktika Tekade, Prashant Kesharwani, Pallab Bhattacharya, Rahul Maheshwari, Kamal Dua, Philp M Hansbro, Rakesh Kumar Tekade
BACKGROUND: Disseminated metastatic cancer requires insistent management owing to its reduced responsiveness for chemotherapeutic agents, toxicity to normal cells consequently lower survival rate and hampered quality of life of patients. METHODS: Dendrimer mediated cancer therapy is advantageous over conventional chemotherapy, radiotherapy and surgical resection due to reduced systemic toxicity, and molecular level cell injury to cancerous mass, for an appreciable survival of the subject...
March 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28191450/remotely-triggered-nano-theranostics-for-cancer-applications
#7
Alexandra Sneider, Derek VanDyke, Shailee Paliwal, Prakash Rai
Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response, and, if required, initiate secondary treatments. Recent in vivo experiments demonstrate the promise of using theranostics in the clinic. In this paper, we review the use of remotely triggered theranostic nanoparticles for cancer applications, focusing heavily on advances in the past five years. Remote triggering mechanisms covered include photodynamic, photothermal, phototriggered chemotherapeutic release, ultrasound, electro-thermal, magneto-thermal, X-ray, and radiofrequency therapies...
2017: Nanotheranostics
https://www.readbyqxmd.com/read/28106955/cypate-mediated-thermosensitive-nanoliposome-for-tumor-imaging-and-photothermal-triggered-drug-release
#8
Zhihao Han, Liwei Lv, Yi Ma, Zhaohui Wang, Yuxi Liu, Min Zhang, Siwen Li, Yueqing Gu
It is an emerging focus to explore controlled release drug delivery systems for simultaneous cancer imaging and therapy. Herein, we synthesized a photothermal sensitive multifunctional nano-liposome drug delivery system, with doxorubicin wrapped in the hydropholic layer as the therapeutical agent and cypate doped in the hydrophobic layer as the diagnostic agent. A series of in vitro and in vivo characterization demonstrated the stability of synthesized liposome, as the DL% was 9 ± 1.5 and the EE% was 82.7 ± 2...
January 20, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/27461058/ballistic-heat-transport-in-laser-generated-nano-bubbles
#9
Julien Lombard, Thierry Biben, Samy Merabia
Nanobubbles generated by laser heated plasmonic nanoparticles are of interest for biomedical and energy harvesting applications. Of utmost importance is the maximal size of these transient bubbles. Here, we report hydrodynamic phase field simulations of the dynamics of laser induced nanobubbles, with the aim to understand which physical processes govern their maximal size. We show that the nanobubble maximal size and lifetime are to a large extent controlled by the ballistic thermal flux which is present inside the bubble...
August 4, 2016: Nanoscale
https://www.readbyqxmd.com/read/27264551/nanotechnology-in-hyperthermia-cancer-therapy-from-fundamental-principles-to-advanced-applications
#10
REVIEW
Jaber Beik, Ziaeddin Abed, Fatemeh S Ghoreishi, Samira Hosseini-Nami, Saeed Mehrzadi, Ali Shakeri-Zadeh, S Kamran Kamrava
In this work, we present an in-depth review of recent breakthroughs in nanotechnology for hyperthermia cancer therapy. Conventional hyperthermia methods do not thermally discriminate between the target and the surrounding normal tissues, and this non-selective tissue heating can lead to serious side effects. Nanotechnology is expected to have great potential to revolutionize current hyperthermia methods. To find an appropriate place in cancer treatment, all nanotechnology-based hyperthermia methods and their risks/benefits must be thoroughly understood...
August 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27154500/synthesis-of-intracellular-reduction-sensitive-amphiphilic-polyethyleneimine-and-poly-%C3%AE%C2%B5-caprolactone-graft-copolymer-for-on-demand-release-of-doxorubicin-and-p53-plasmid-dna
#11
Pooya Davoodi, Madapusi P Srinivasan, Chi-Hwa Wang
UNLABELLED: This study aims to present a new intelligent polymeric nano-system used for combining chemotherapy with non-viral gene therapy against human cancers. An amphiphilic copolymer synthesized through the conjugation of low molecular weight polyethyleneimine (LMw-PEI) and poly(ε-caprolactone) (PCL) via a bio-cleavable disulfide linkage was successfully employed for the simultaneous delivery of drug and gene molecules into target cells. Compared to the conventional PCL copolymerization pathway, this paper represents a straightforward and efficient reaction pathway including the activation of PCL-diol hydroxyl end groups, cystamine attachment and LMw-PEI conjugation which are successfully performed at mild conditions as confirmed by FTIR and (1)H NMR...
July 15, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27151045/image-guided-thermal-therapy-with-a-dual-contrast-magnetic-nanoparticle-formulation-a-feasibility-study
#12
Anilchandra Attaluri, Madhav Seshadri, Sahar Mirpour, Michele Wabler, Thomas Marinho, Muhammad Furqan, Haoming Zhou, Silvia De Paoli, Cordula Gruettner, Wesley Gilson, Theodore DeWeese, Monica Garcia, Robert Ivkov, Eleni Liapi
PURPOSE/OBJECTIVE: The aim of this study was to develop and investigate the properties of a magnetic iron oxide nanoparticle-ethiodised oil formulation for image-guided thermal therapy of liver cancer. MATERIALS AND METHODS: The formulation comprises bionised nano-ferrite (BNF) nanoparticles suspended in ethiodised oil, emulsified with polysorbate 20 (BNF-lip). Nanoparticle size was measured via photon correlation spectroscopy and transmission electron microscopy...
August 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/26340627/synthesis-and-characterization-of-chitosan-coated-near-infrared-nir-layered-double-hydroxide-indocyanine-green-nanocomposites-for-potential-applications-in-photodynamic-therapy
#13
Pei-Ru Wei, Yaswanth Kuthati, Ranjith Kumar Kankala, Chia-Hung Lee
We designed a study for photodynamic therapy (PDT) using chitosan coated Mg-Al layered double hydroxide (LDH) nanoparticles as the delivery system. A Food and Drug Administration (FDA) approved near-infrared (NIR) fluorescent dye, indocyanine green (ICG) with photoactive properties was intercalated into amine modified LDH interlayers by ion-exchange. The efficient positively charged polymer (chitosan (CS)) coating was achieved by the cross linkage using surface amine groups modified on the LDH nanoparticle surface with glutaraldehyde as a spacer...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26234249/graphene-like-two-dimensional-layered-nanomaterials-applications-in-biosensors-and-nanomedicine
#14
Guohai Yang, Chengzhou Zhu, Dan Du, Junjie Zhu, Yuehe Lin
The development of nanotechnology provides promising opportunities for various important applications. The recent discovery of atomically-thick two-dimensional (2D) nanomaterials can offer manifold perspectives to construct versatile devices with high-performance to satisfy multiple requirements. Many studies directed at graphene have stimulated renewed interest on graphene-like 2D layered nanomaterials (GLNs). GLNs including boron nitride nanosheets, graphitic-carbon nitride nanosheets and transition metal dichalcogenides (e...
September 14, 2015: Nanoscale
https://www.readbyqxmd.com/read/26093792/an-imaging-guided-platform-for-synergistic-photodynamic-photothermal-chemo-therapy-with-ph-temperature-responsive-drug-release
#15
Ruichan Lv, Piaoping Yang, Fei He, Shili Gai, Guixin Yang, Yunlu Dai, Zhiyao Hou, Jun Lin
To integrate biological imaging and multimodal therapies into one platform for enhanced anti-cancer efficacy, we have designed a novel core/shell structured nano-theranostic by conjugating photosensitive Au25(SR)18 - (SR refers to thiolate) clusters, pH/temperature-responsive polymer P(NIPAm-MAA), and anti-cancer drug (doxorubicin, DOX) onto the surface of mesoporous silica coated core-shell up-conversion nanoparticles (UCNPs). It is found that the photodynamic therapy (PDT) derived from the generated reactive oxygen species and the photothermal therapy (PTT) arising from the photothermal effect can be simultaneously triggered by a single 980 nm near infrared (NIR) light...
September 2015: Biomaterials
https://www.readbyqxmd.com/read/26005762/ph-triggered-in%C3%A2-vivo-photothermal-therapy-and-fluorescence-nanoplatform-of-cancer-based-on-responsive-polymer-indocyanine-green-integrated-reduced-graphene-oxide
#16
Shazid Md Sharker, Jung Eun Lee, Sung Han Kim, Ji Hoon Jeong, Insik In, Haeshin Lee, Sung Young Park
We have synthesized a pH-dependent, NIR-sensitive, reduced graphene oxide (rGO) hybrid nano-composite via electrostatic interaction with indocyanine green (ICG) which is designed not only to destroy localized cancer cells but also be minimally invasive to surrounding normal cells. The near-infrared (NIR) irradiated hybrid nano-composites showed pH dependent photo-thermal heat generation capability from pH 5.0 to 7.4 due to the pH response relief and quenching effects of poly(2-dimethyl amino ethyl methacrylate) [poly(PDMAEMA)] with ICG on a single rGO sheet...
August 2015: Biomaterials
https://www.readbyqxmd.com/read/25744825/radio-frequency-responsive-nano-biomaterials-for-cancer-therapy
#17
REVIEW
N Sanoj Rejinold, R Jayakumar, Yeu-Chun Kim
Radiofrequency (RF)-assisted cancer therapy is well-known in the medical field as it is non-hazardous and can penetrate tissues, enabling a deeply rooted cancer treatment. However, the current treatment regimen is non-specific and invasive, making it difficult for patients to undergo the RF ablation procedure. Recently, there has been tremendous attention given on replacing RF probes (through which the RF current passes into the tumors) with metallic nanoparticles (NPs) such as gold and iron oxide. These metallic NPs can be combined with stimuli responsive polymers to have a simultaneous drug delivery to tumors and better thermal ablation...
April 28, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/24981660/advanced-nanovehicles-for-cancer-management
#18
REVIEW
L Saenz del Burgo, J L Pedraz, G Orive
Over the past decade, together with the improvement of traditional cancer treatments, conveniently designed (with respect to their size, shape, main material, and coating) and specifically targeted nanovehicles have been developed. Nano-sized carriers can be functionalized to recognize key structures expressed in cancer cells and/or their surrounding tissues. Recently, some more complex systems have been developed that exploit the human body's own communication systems to enhance their efficacy. Some of the newest nanoparticles have the capacity to not only serve as drug delivery systems for a myriad of molecules, but also operate as direct cancer treatment agents themselves, such as in thermal therapies...
October 2014: Drug Discovery Today
https://www.readbyqxmd.com/read/24955141/enhanced-plasmonic-resonance-energy-transfer-in-mesoporous-silica-encased-gold-nanorod-for-two-photon-activated-photodynamic-therapy
#19
Nai-Tzu Chen, Kuo-Chun Tang, Ming-Fang Chung, Shih-Hsun Cheng, Ching-Mao Huang, Chia-Hui Chu, Pi-Tai Chou, Jeffrey S Souris, Chin-Tu Chen, Chung-Yuan Mou, Leu-Wei Lo
The unique optical properties of gold nanorods (GNRs) have recently drawn considerable interest from those working in in vivo biomolecular sensing and bioimaging. Especially appealing in these applications is the plasmon-enhanced photoluminescence of GNRs induced by two-photon excitation at infrared wavelengths, owing to the significant penetration depth of infrared light in tissue. Unfortunately, many studies have also shown that often the intensity of pulsed coherent irradiation of GNRs needed results in irreversible deformation of GNRs, greatly reducing their two-photon luminescence (TPL) emission intensity...
2014: Theranostics
https://www.readbyqxmd.com/read/24389151/bio-effects-of-non-ionizing-electromagnetic-fields-in-context-of-cancer-therapy
#20
REVIEW
Timur Saliev, Katsuro Tachibana, Denis Bulanin, Sergey Mikhalovsky, Ray D L Whitby
Bio-effects mediated by non-ionizing electromagnetic fields (EMF) have become a hot topic of research in the last decades. This interest has been triggered by a growing public concern about the rapid expansion of telecommunication devices and possible consequences of their use on human health. Despite a feasibility study of potential negative impacts, the therapeutic advantages of EMF could be effectively harnessed for the treatment of cancer and other diseases. This review aims to examine recent findings relating to the mechanisms of action underlying the bio-effects induced by non-ionizing EMF...
2014: Frontiers in Bioscience (Elite Edition)
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