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Cancer therapy nano

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https://www.readbyqxmd.com/read/29158823/engineered-zn-ii-dipicolylamine-gold-nanorod-provides-effective-prostate-cancer-treatment-by-combining-sirna-delivery-and-photothermal-therapy
#1
Kyung Hyun Min, Young-Hwa Kim, Zhantong Wang, Jihoon Kim, Jee Seon Kim, Sun Hwa Kim, Kwangmeyung Kim, Ick Chan Kwon, Dale O Kiesewetter, Xiaoyuan Chen
Combination cancer treatment has emerged as a critical approach to achieve remarkable anticancer effect. In this study, we prepared a theranostic nanoformulation that allows for photoacoustic imaging as well as combination gene and photothermal therapy. Gold nanorods (GNR) were coated with dipicolyl amine (DPA), which forms stable complexes with Zn(2+) cations. The resulting nanoparticles, Zn(II)/DPA-GNR, recognize phosphate-containing molecules, including siRNA, because of the specific interaction between Zn(II) and the phosphates...
2017: Theranostics
https://www.readbyqxmd.com/read/29158820/ph-sensitive-nano-complexes-overcome-drug-resistance-and-inhibit-metastasis-of-breast-cancer-by-silencing-akt-expression
#2
Jieying Yin, Tianqun Lang, Dongmei Cun, Zhong Zheng, Yan Huang, Qi Yin, Haijun Yu, Yaping Li
The therapy of breast cancer is encumbered by drug resistance and metastasis, which can be due to a defective PI3K/AKT/mTOR signaling pathway. This study was aimed at improving the anti-cancer effect of the chemotherapeutic agent paclitaxel (PTX) on the drug resistant and metastatic breast cancer by co-delivering PTX and a siRNA, siAkt, directed at silencing the Akt expression. Methods: The pH-sensitive amphiphilic polymer, poly [(1,4-butanediol)-diacrylate-β-N, N-diisopropylethylenediamine]-polyethyleneimine (BDP) was synthesized...
2017: Theranostics
https://www.readbyqxmd.com/read/29155336/evaluation-of-the-combined-effect-of-nir-laser-and-ionizing-radiation-on-cellular-damages-induced-by-iudr-loaded-plga-coated-nano-graphene-oxide
#3
Samira Kargar, Samideh Khoei, Sepideh Khoee, Sakine Shirvalilou, Seied Rabi Mahdavi
Glioma is one of the most common malignant cancers of the central nervous system (CNS). Radiatherapy and chemotherapy may be used to slow the growth of tumors that cannot be removed with surgery. The current study developed a combination therapy tool using Nanographene oxide (NGO) functionalized with poly lactic-co-glycolic acid (PLGA) as a carrier of 5-iodo-2-deoxyuridine (IUdR) for glioma cancer treatment. U87MG cells were treated in different groups with IUdR, PLGA-coated Nanographene oxide (PLGA-NGO), IUdR-loaded PLGA-coated Nanographene oxide (IUdR-PLGA-NGO), 2Gy 6MV X-ray radiation, and near-infrared region (NIR) laser radiation...
November 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29146540/temperature-sensitive-copolymer-coated-fluorescent-mesoporous-silica-nanoparticles-as-a-reactive-oxygen-species-activated-drug-delivery-system
#4
Feng Yu, Huijing Wu, Yao Tang, Yufang Xu, Xuhong Qian, Weiping Zhu
In this study, a temperature and ROS-responsive drug delivery system ROSP@MSN based on mesoporous silica nanoparticles has been designed and synthesized by taking advantage of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acrylate modified polymers (ROSP) as "nano-valve", which can respond selectively to cancer exclusive microenvironment and implement targeted drug release. Due to the superior temperature-sensitive properties of ROSP, ROSP@MSN could achieve cargo loading in cold water, and subsequently close the pore by raising temperature to obtain ROSP@MSN@DOX...
November 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29135959/intratumoral-delivery-of-doxorubicin-on-folate-conjugated-graphene-oxide-by-in-situ-forming-thermo-sensitive-hydrogel-for-breast-cancer-therapy
#5
Yi Teng Fong, Chih-Hao Chen, Jyh-Ping Chen
By taking advantage of the pH-sensitive drug release property of graphene oxide (GO) after intracellular uptake, we prepared folic acid (FA)-conjugated GO (GOFA) for targeted delivery of the chemotherapeutic drug doxorubicin (DOX). GOFA-DOX was further encapsulated in an injectable in-situ forming thermo-sensitive hyaluronic acid-chitosan-g-poly(N-isopropylacrylamide) (HACPN) hydrogel for intratumoral delivery of DOX. As the degradation time of HACPN could be extended up to 3 weeks, intratumoral delivery of GOFA-DOX/HACPN could provide controlled and targeted delivery of DOX through slow degradation HACPN and subsequent cellular uptake of released GOFA-DOX by tumor cells through interactions of GOFA with folate receptors on the tumor cell's surface...
November 14, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29129076/comprehensive-molecular-characterization-of-a-cisplatin-specific-monoclonal-antibody
#6
Lena Ruhe, Stefanie Ickert, Ulrike Hochkirch, Johanna Hofmann, Sebastian Beck, Jürgen Thomale, Michael W Linscheid
Despite their immense and rapidly increasing importance as analytical tools or therapeutic drugs, the detailed structural features of particular monoclonal antibodies are widely unknown. Here, an antibody already in use for diagnostic purposes and for molecular dosimetry studies in cancer therapy with very high affinity and specificity for cisplatin-induced DNA modifications was studied extensively. The molecular structure and modifications as well as the antigen specificity were investigated mainly by mass spectrometry...
November 11, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29124979/mesoporous-carbon-nanomaterials-in-drug-delivery-and-biomedical-application
#7
Qinfu Zhao, Yuanzhe Lin, Ning Han, Xian Li, Hongjian Geng, Xiudan Wang, Yu Cui, Siling Wang
Recent development of nano-technology provides highly efficient and versatile treatment methods to achieve better therapeutic efficacy and lower side effects of malignant cancer. The exploration of drug delivery systems (DDSs) based on nano-material shows great promise in translating nano-technology to clinical use to benefit patients. As an emerging inorganic nanomaterial, mesoporous carbon nanomaterials (MCNs) possess both the mesoporous structure and the carbonaceous composition, endowing them with superior nature compared with mesoporous silica nanomaterials and other carbon-based materials, such as carbon nanotube, graphene and fullerene...
2017: Drug Delivery
https://www.readbyqxmd.com/read/29123482/anticancer-activities-of-surfactin-and-potential-application-of-nanotechnology-assisted-surfactin-delivery
#8
REVIEW
Yuan-Seng Wu, Siew-Ching Ngai, Bey-Hing Goh, Kok-Gan Chan, Learn-Han Lee, Lay-Hong Chuah
Surfactin, a cyclic lipopeptide biosurfactant produced by various strains of Bacillus genus, has been shown to induce cytotoxicity against many cancer types, such as Ehrlich ascites, breast and colon cancers, leukemia and hepatoma. Surfactin treatment can inhibit cancer progression by growth inhibition, cell cycle arrest, apoptosis, and metastasis arrest. Owing to the potent effect of surfactin on cancer cells, numerous studies have recently investigated the mechanisms that underlie its anticancer activity...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29109766/cancer-nanomedicines-stabilized-by-%C3%AF-%C3%AF-stacking-between-heterodimeric-prodrugs-enable-exceptionally-high-drug-loading-capacity-and-safer-delivery-of-drug-combinations
#9
Hangxiang Wang, Jianmei Chen, Chang Xu, Linlin Shi, Munire Tayier, Jiahui Zhou, Jun Zhang, Jiaping Wu, Zhijian Ye, Tao Fang, Weidong Han
Combination therapy using distinct mode-of-action drugs has sparked a rapidly growing interest because this paradigm holds promise for improving the therapeutic efficacy of anticancer therapy. However, the current drug combination therapy refers to administering individual drugs together, which is far from a perfect regimen for cancer patients. The aim of this work was to demonstrate that synergistic delivery of two chemotherapeutic drugs in a single nanoparticle reservoir could be achieved through the rational chemical ligation of the drugs followed by supramolecular nano-assembly via blending of the drugs with a minimal amount of matrix...
2017: Theranostics
https://www.readbyqxmd.com/read/29103516/1-3%C3%AE-glucan-anchored-paclitaxel-loaded-chitosan-nanocarrier-endows-enhanced-hemocompatibility-with-efficient-anti-glioblastoma-stem-cells-therapy
#10
Pankaj K Singh, Anup K Srivastava, Atul Dev, Babita Kaundal, Subhasree Roy Choudhury, Surajit Karmakar
Recurrence of glioblastoma is one of the major concerns due to its heterogeneous nature and association of Glioma Initiating stem-like Cells (GICs). Nanoparticles mediated delivery of chemotherapeutic agent targeting both cancer and glioma stem cells could provide a solution to recurrent malignancies of the glioblastoma tumor. The approach described here provides enhanced chemotherapeutic potency utilizing 1,3β-Glucan as an outer shell to the chitosan nanoparticles (Cs-NPs) loaded with paclitaxel to prevent hemolysis with, the core-shell nano-structure (Cs-PTX-NP) enabling effective chemotherapy against malignant glioblastoma...
January 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29101365/biomineral-nano-theranostic-agent-for-magnetic-resonance-image-guided-augmented-radiofrequency-ablation-of-liver-tumor
#11
Anusha Ashokan, Vijay Harish Somasundaram, Genekehal Siddaramana Gowd, Ida M Anna, Giridharan L Malarvizhi, Badrinathan Sridharan, Rupal B Jobanputra, Reshmi Peethambaran, A K K Unni, Shantikumar Nair, Manzoor Koyakutty
Theranostic nanoparticles based on biocompatible mineral compositions can significantly improve the translational potential of image guided cancer nano-therapy. Here, we report development of a single-phase calcium phosphate biomineral nanoparticle (nCP) with dual-mode magnetic resonance contrast (T1-T2) together with radiofrequency (RF) mediated thermal response suitable for image-guided RF ablation of cancer. The nanoparticles (NP) are engineered to provide dual MR contrast by an optimized doping concentration (4...
November 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29088978/the-biological-challenges-and-pharmacological-opportunities-of-orally-administered-nanomedicine-delivery
#12
Darren Michael Moss, Paul Curley, Hannah Kinvig, Clare Hoskins, Andrew Owen
Nano-scale formulations are being developed to improve the delivery of orally administered medicines, and the interactions between nanoformulations and the gastrointestinal luminal, mucosal and epithelial environment is currently being investigated. The mucosal surface of the gastrointestinal tract is capable of trapping and eliminating large particles and pathogens as part of the natural defences of the body, it is becoming clearer that nanoformulation properties such as particle size, charge, and shape, as well as mucous properties such as viscoelasticity, thickness, density, and turn-over time are all relevant to these interactions...
November 1, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29083232/co-delivery-of-curcumin-and-chrysin-by-polymeric-nanoparticles-inhibit-synergistically-growth-and-htert-gene-expression-in-human-colorectal-cancer-cells
#13
Javid Lotfi-Attari, Younes Pilehvar-Soltanahmadi, Mehdi Dadashpour, Shahriar Alipour, Raana Farajzadeh, Shahrzad Javidfar, Nosratollah Zarghami
Nanoparticle (NP)-based combinational chemotherapy has been proposed as a potent approach for improving intracellular drug concentrations and attaining synergistic effects in colorectal cancer therapy. Here, two well-known herbal substances, Curcumin (Cur) and Chrysin (Chr), were co-encapsulated in PEGylated PLGA NPs and investigated their synergistic inhibitory effect against Caco-2 cancer cells. Characterization of nanoformulated drugs was determined using DLS, FTIR, TEM, and SEM. Drug release study was performed using dialysis method...
October 30, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29072767/biocompatible-silver-gold-and-silver-gold-alloy-nanoparticles-for-enhanced-cancer-therapy-in-vitro-and-in-vivo-perspectives
#14
Thangavel Shanmugasundaram, Manikkam Radhakrishnan, Venugopal Gopikrishnan, Krishna Kadirvelu, Ramasamy Balagurunathan
The aims of nano oncology are to detect, target and treat cancer cells without any side effects. The present study describes the microbial synthesis of biocompatible nanoparticles of silver (AgNPs), gold (AuNPs) and their alloy (Ag/AuNPs) for hepatoprotective activity against diethylnitrosamine (DEN)-induced liver cancer in a Sprague Dawley (SD) rat model. The crystalline nature and physicochemical features of the nanoparticles were identified by Fourier transform infra-red (FT-IR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM) and selected area electron diffraction (SAED) analysis...
November 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/29061103/integration-of-nano-drug-delivery-system-with-cancer-immunotherapy
#15
Takashi Nakamura, Hideyoshi Harashima
Immune checkpoint therapy represents a new, revolutionary type of cancer therapy, but emerging evidence indicates that only a minority of patients will benefit from it. The issue of how to improve and widen the clinical response is a pivotal issue, and combining other types of therapy with immune checkpoint inhibitors is currently under development. A nanotechnology-based drug-delivery system (nano DDS) could be an important contribution to the development of an effective combination therapy. In this document, we review recent findings in the field of tumor immunology, which provide a strategy for an efficient combination therapy, and discuss nano DDS that are associated with cancer immunotherapy and nano DDS strategies based on the immune status in tumor microenvironments...
November 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/29058908/intracellular-fate-of-nanoparticles-with-polydopamine-surface-engineering-and-a-novel-strategy-for-exocytosis-inhibiting-lysosome-impairment-based-cancer-therapy
#16
Li Ding, Xianbing Zhu, Yiling Wang, Bingyang Shi, Xiang Ling, Houjie Chen, Wenhao Nan, Austin Barrett, Zilei Guo, Wei Tao, Jun Wu, Xiaojun Shi
Polydopamine (PDA) coating as a bioinspired strategy for nanoparticles (NPs) has been extensively applied in cancer theranostics. However, a cellular-level understanding of nano-biointeraction of these PDA-coated NPs (PDNPs), which drives the fate of them and acts as a critical step to determine their efficacy, still remains unknown. Herein, we utilized the representative mesoporous silica NPs (MSNs) to be coated with PDA and study their nano-bioactivities in cancer cells. HeLa cell line was utilized as a model in this study...
October 27, 2017: Nano Letters
https://www.readbyqxmd.com/read/29055700/anti-trop2-antibody-conjugated-bioreducible-nanoparticles-for-targeted-triple-negative-breast-cancer-therapy
#17
Soyoung Son, Sol Shin, N Vijayakameswara Rao, Wooram Um, Jueun Jeon, Hyewon Ko, V G Deepagan, Seunglee Kwon, Jun Young Lee, Jae Hyung Park
Trop2, a transmembrane glycoprotein, has emerged as a biomarker for targeted cancer therapy since it is overexpressed in 80% of triple negative breast cancer (TNBC) patients. For the site-specific delivery of the anticancer drug into TNBC, anti-Trop2 antibody-conjugated nanoparticles (ST-NPs) were prepared as the potential nanocarrier, composed of carboxymethyl dextran (CMD) derivatives with bioreducible disulfide bonds. Owing to its amphiphilicity, the CMD derivatives were self-assembled into nano-sized particles in an aqueous condition...
October 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29046993/synthesis-and-in-vitro-performance-of-polypyrrole-coated-iron-platinum-nanoparticles-for-photothermal-therapy-and-photoacoustic-imaging
#18
Thi Tuong Vy Phan, Nhat Quang Bui, Madhappan Santha Moorthy, Kang Dae Lee, Junghwan Oh
Multifunctional nano-platform for the combination of photo-based therapy and photoacoustic imaging (PAI) for cancer treatment has recently attracted much attention to nanotechnology development. In this study, we developed iron-platinum nanoparticles (FePt NPs) with the polypyrrole (PPy) coating as novel agents for combined photothermal therapy (PTT) and PAI. The obtained PPy-coated FePt NPs (FePt@PPy NPs) showed excellent biocompatibility, photothermal stability, and high near-infrared (NIR) absorbance for the combination of PTT and PAI...
October 18, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29042665/gdc-0449-improves-the-antitumor-activity-of-nano-doxorubicin-in-pancreatic-cancer-in-a-fibroblast-enriched-microenvironment
#19
Quan Zhou, Yongcun Zhou, Xiangrui Liu, Youqing Shen
Pancreatic cancer is one of the most lethal human cancers that currently does not have effective therapies. Novel treatments including nanomedicines and combination therapies are thus urgently needed for these types of deadly diseases. A key feature of pancreatic cancer is its tumor protective dense stroma, which is generated by cancer-associated fibroblasts (CAFs). The interaction between CAFs and pancreatic cancer cells abnormally activates sonic hedgehog (SHH) signaling and facilitates tumor growth, metastasis, and drug resistance...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29038584/dual-drug-containing-core-shell-nanoparticles-for-lung-cancer-therapy
#20
Jyothi U Menon, Aneetta Kuriakose, Roshni Iyer, Elizabeth Hernandez, Leah Gandee, Shanrong Zhang, Masaya Takahashi, Zhang Zhang, Debabrata Saha, Kytai T Nguyen
Late-stage diagnosis of lung cancer occurs ~95% of the time due to late manifestation of its symptoms, necessitating rigorous treatment following diagnosis. Existing treatment methods are limited by lack of specificity, systemic toxicity, temporary remission, and radio-resistance in lung cancer cells. In this research, we have developed a folate receptor-targeting multifunctional dual drug-loaded nanoparticle (MDNP) containing a poly(N-isopropylacrylamide)-carboxymethyl chitosan shell and poly lactic-co-glycolic acid (PLGA) core for enhancing localized chemo-radiotherapy to effectively treat lung cancers...
October 16, 2017: Scientific Reports
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