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Cancer therapy nano

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https://www.readbyqxmd.com/read/28708066/novel-selective-detection-method-of-tumor-angiogenesis-factors-using-living-nano-robots
#1
Mohamed Al-Fandi, Nida Alshraiedeh, Rami Owies, Hala Alshdaifat, Omamah Al-Mahaseneh, Khadijah Al-Tall, Rawan Alawneh
This paper reports a novel self-detection method for tumor cells using living nano-robots. These living robots are a nonpathogenic strain of E. coli bacteria equipped with naturally synthesized bio-nano-sensory systems that have an affinity to VEGF, an angiogenic factor overly-expressed by cancer cells. The VEGF-affinity/chemotaxis was assessed using several assays including the capillary chemotaxis assay, chemotaxis assay on soft agar, and chemotaxis assay on solid agar. In addition, a microfluidic device was developed to possibly discover tumor cells through the overexpressed vascular endothelial growth factor (VEGF)...
July 14, 2017: Sensors
https://www.readbyqxmd.com/read/28707589/advances-in-the-anticancer-value-of-the-ursolic-acid-through-nanodelivery
#2
Azadeh Manayi, Marjan Nikan, Navid Nobakht Haghighid, Mohammad Abdollahi
Ursolic acid, a natural pentacyclic triterpenoid is commonly found in plants and foods with promising biological and pharmacological activities. The compound has been under the attention of researchers due to its considerable anticancer effects through suppression of differentiation, angiogenesis, invasion, and metastasis of tumor cells via different pathways with low toxicity. Bioavailability of ursolic acid is poor due to poor solubility of the compound in water. Low bioavailability and short plasma half-life of ursolic acid along with non-specific distribution in the body are considered as impediments in the therapeutic development of the compound...
July 13, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28706754/smart-release-nano-formulation-of-cytochrome-c-and-hyaluronic-acid-induces-apoptosis-in-cancer-cells
#3
C M Figueroa, B N Suárez, A M Molina, J C Fernández, Z Torres, K Griebenow
Herein we tested a nanosized cancer-cell targeted delivery system based on cytochrome c (Cyt c) and hyaluronic acid. Cyt c was chosen since it is a per se non-toxic protein but causes apoptosis when delivered to the cytoplasm of target cells. Hyaluronic acid was employed to create the nanosized delivery system with passive targeting capability in order to exploit the enhanced permeation and retention (EPR) effect and active targeting capability of hyaluronic acid. In addition, our goal was to incorporate a smart release strategy to only promote protein release upon reaching its target...
February 2017: Journal of Nanomedicine & Nanotechnology
https://www.readbyqxmd.com/read/28704056/a-nano-in-nano-polymer-dendrimer-nanoparticle-based-nanosystem-for-controlled-multi-drug-delivery
#4
Zongmin Zhao, Song Lou, Yun Hu, Jie Zhu, Chenming Zhang
Co-delivery of multiple chemotherapeutics with different action mechanisms is a promising strategy for cancer treatment. In this study, we developed a novel polymer-dendrimer hybrid nanoparticle-based nanosystem for efficient and controlled co-delivery of two model chemotherapeutics, doxorubicin (DOX) and paclitaxel (PTX). The nanosystem was characterized to have a nano-in-nano structure with a size of around 150 nm. The model drugs could feasibly be loaded into the nanosystem ratiometrically with high drug loading contents by controlling the feeding drug ratios...
July 13, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28702620/nanoparticle-delivery-of-curcumin-induces-cellular-hypoxia-and-ros-mediated-apoptosis-via-modulation-of-bcl-2-bax-in-human-neuroblastoma
#5
Irina Kalashnikova, Joseph Mazar, Craig J Neal, Amy L Rosado, Soumen Das, Tamarah J Westmoreland, Sudipta Seal
In this study, several formulations of nanoceria and dextran-nanoceria with curcumin, each demonstrated to have anti-cancer properties, were synthesized and applied as treatment for human childhood neuroblastoma. The anti-cancer activities of these formulations were explored in neuroblastoma models of both MYCN-amplified and non-amplified cell lines. Ceria nanoparticles, coated with dextran and loaded with curcumin, were found to induce substantial cell death in neuroblastoma cells (up to a 2-fold and a 1.6-fold decrease in cell viability for MYCN-upregulated and normal expressing cell lines, respectively; *p < 0...
July 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28702600/an-nir-sensitive-layered-supramolecular-nanovehicle-for-combined-dual-modal-imaging-and-synergistic-therapy
#6
Shanyue Guan, Yangziwan Weng, Mengnan Li, Ruizheng Liang, Chenghua Sun, Xiaozhong Qu, Shuyun Zhou
A supramolecular nanovehicle, denoted as ICG-DOX/Gd-LDH, was synthesized by the co-intercalation of indocyanine green (ICG) and doxorubicin hydrochloride (DOX) into a gallery of Gd(3+)-doped-layered double hydroxide (Gd-LDH) such that to achieve a chemo-photothermal synergistic therapeutic agent. The unique structure of Gd-LDH can not only stabilize the photothermal agent ICG to enhance the photothermal efficiency, but also hamper the recombination between electron and holes, leading to the generation of more reactive oxygen species (ROS) under irradiation in the NIR range...
July 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28699518/nano-sized-ultrasound-contrast-agents-for-cancer-therapy-and-theranostics
#7
Hao Li, Shenglong Gan, Shi-Ting Feng, Guofu Zhou, Zhi Dong, Rongqin Zheng, Zi-Ping Li
Ultrasound contrast agents (UCA) represented by gas-filled microbubble, can provide simultaneous and co-localized enhancement on image contrast to help disease diagnosis by highlighting tissue borders. Nowadays, Some UCAs (e.g. Levovist®, Optison®, Definity®, and Sonovue®) are commercially available, and have been clinically utilized for enhanced ultrasonography in the US, Canada, Europe, Asia and so on. However, their large diameters (1~10 μm) mainly hinder more precise and deeper applications in the imaging of capillary-abundant organs or tissues (e...
July 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28699509/combination-of-multifunctional-nanoparticles-and-interventional-techniques-makes-each-other-going-further-in-the-field-of-cancer-treatment
#8
Haibo Shao, Tengchuang Ma, Duo Hong, Wenhan Xu, Shuai Li, Ronald S Arellano, Ke Xu
Nano-oncology and interventional oncology are both rapidly emerging fields in loco-regional cancer therapies. Synergistic combination of both fields offers drastic improvement in performance and efficacy of cancer killings. Interventional techniques such selective arterial catheterization, irreversible electroporation (IRE) and radiofrequency ablation (RFA) had dramatically enhance the cancer targetability and anticancer efficacy of nanoparticles (NPs). Furthermore, there is synergistic effect by using different interventional techniques together on NPs assisted cancer treatment...
July 10, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28694088/enhanced-expression-of-tumour-suppressor-rar-%C3%AE-by-dspc-nano-formulated-lipo-atra-in-the-lung-of-b16f10-cell-implanted-c57bl6-mice-and-in-a549-cells
#9
V M Berlin Grace, Reshma Mahima Reji, Viswanathan Sundaram
AIM: All Trans Retinoic acid (ATRA) is an efficient drug for leukemia, but is not efficient therapy for solid cancers. Hence we have used 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and cholesterol lipo-ATRA to investigate its molecular therapeutic effect on lung cancer. The objective was to find whether it could enhance ATRA receptor, RAR-β expression in lung cells as it was lost in majority of cancers including lung cancer. MATERIALS AND METHODS: The study was made in an experimental C57BL/6 mice model developed by tail vein injection of B16F10 cells and in A549 human lung cancer cells...
July 7, 2017: Life Sciences
https://www.readbyqxmd.com/read/28694026/nano-technology-based-carriers-for-nitrogen-containing-bisphosphonates-delivery-as-sensitisers-of-%C3%AE-%C3%AE-t-cells-for-anticancer-immunotherapy
#10
Naomi O Hodgins, Julie Tzu-Wen Wang, Khuloud T Al-Jamal
Nitrogen containing bisphosphonates (N-BPs) including zoledronate (ZOL) and alendronate (ALD) inhibit farnesyl diphosphate synthase, and have been shown to have a cytotoxic affect against cancer cells as a monotherapy and to also sensitise tumour cells to destruction by γδ T cells. γδ T cells are a subset of human T lymphocytes and have a diverse range of roles in the immune system including the recognition and destruction of cancer cells. This property of γδ T cells can be harnessed for use in cancer immunotherapy through in vivo expansion or the adoptive transfer of ex vivo activated γδ T cells...
July 7, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28690099/electrospun-polymeric-nanofibers-new-horizons-in-drug-delivery
#11
REVIEW
Shreya Thakkar, Manju Misra
Nanofibers obtained using electrospinning technique are being used since ages especially in fields of textile industry, sensors, filters, protective clothing and tissue engineering. Their use as drug delivery system is an emerging platform in the field of pharmaceuticals and now-a-days formulation scientists are paying great attention to the technology due to several advantages prime being easy modulation of drug release profile depending upon the properties of polymer/polymeric blends/other materials used...
July 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28685585/the-effects-of-combined-selenium-nanoparticles-and-radiation-therapy-on-breast-cancer-cells-in-vitro
#12
Feng Chen, Xiao Hong Zhang, Xiao Dan Hu, Pei Dang Liu, Hai Qian Zhang
Radiosensitizers that increase cancer cell radio-sensitivity can enhance the effectiveness of irradiation and minimize collateral damage. Nanomaterial has been employed in conjunction with radiotherapy as radiosensitizers, due to its unique physicochemical properties. In this article, we evaluated selenium nanoparticles (Nano-Se) as a new radiosensitizer. Nano-Se was used in conjunction with irradiation on MCF-7 breast cancer cells, and efficacy and mechanisms of this combined treatment approach were evaluated...
July 7, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28685231/hybrid-polymeric-protein-nano-carriers-hppnc-for-targeted-delivery-of-tgf%C3%AE-inhibitors-to-hepatocellular-carcinoma-cells
#13
Nemany A N Hanafy, Alessandra Quarta, Riccardo Di Corato, Luciana Dini, Concetta Nobile, Vittorianna Tasco, Sonia Carallo, Mariafrancesca Cascione, Andrea Malfettone, Jitka Soukupova, Rosaria Rinaldi, Isabel Fabregat, Stefano Leporatti
TGFβ1 pathway antagonists have been considered promising therapies to attenuate TGFβ downstream signals in cancer cells. Inhibiting peptides, as P-17 in this study, are bound to either TGFβ1 or its receptors, blocking signal transduction. However, for efficient use of these TGFβ1antagonist as target therapeutic tools, improvement in their delivery is required. Here, a plasmid carrying specific shDNA (SHT-DNA), small interfering RNA (siRNA), and the peptide (P-17) were loaded separately into folic acid (FA)-functionalized nano-carriers made of Bovine Serum Albumin (BSA)...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28681663/graphene-oxide-methylene-blue-nanocomposite-in-photodynamic-therapy-of-human-breast-cancer
#14
Reza Hosseinzadeh, Khatereh Khorsandi, Ghader Hosseinzadeh
The interaction of methylene blue (MB) as a photosensitizer with graphene oxide nano-sheets (GO) was examined in aqueous solution using UV-vis spectrophotometric techniques. MB-GO composites were prepared by mixing the solutions of GO nano-sheets and methylene blue due to interacting of the cationic methylene blue photosensitizer via electrostatic and π-π stacking or hydrophobic cooperative interactions. The cell killing potential of nanocomposite was examined on the MDA-MB-231 breast cancer cells in the absence and presence of red LED irradiation...
July 6, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28678551/nano-encapsulated-metformin-curcumin-in-plga-peg-inhibits-synergistically-growth-and-htert-gene-expression-in-human-breast-cancer-cells
#15
Raana Farajzadeh, Younes Pilehvar-Soltanahmadi, Mehdi Dadashpour, Shahrzad Javidfar, Javid Lotfi-Attari, Hadi Sadeghzadeh, Vahid Shafiei-Irannejad, Nosratollah Zarghami
The study was aimed at investigating the synergistic inhibitory effect of unique combinational regimen of nanocapsulated Metformin (Met) and Curcumin (Cur) against T47D breast cancer cells. For this purpose, Met and Cur were co-encapsulated in PEGylated PLGA nanoparticles (NPs) and evaluated for their therapeutic efficacy. The morphology and dynamic light scattering (DLS) analyses were carried out to optimize the nanoformulations. Drug release study was performed using dialysis method and then the cytotoxic and inhibitory effect of individual and combined drugs on expression level of hTERT in T47D breast cell line were evaluated using MTT assay and qPCR, respectively...
July 5, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28665111/zwitterionic-temperature-redox-sensitive-nanogels-for-near-infrared-light-triggered-synergistic-thermo-chemotherapy
#16
Fuying Li, Hao Yang, Nana Bie, Qingbo Xu, Tuying Yong, Qin Wang, Lu Gan, Xiangliang Yang
Ideal anticancer nano drug delivery systems (NDDSs) need to overcome a series of physiological barriers including blood circulation, tumor accumulation, tumor penetration, internalization by cancer cells, lysosomal escape, and on-demand intracellular drug release following systemic administration. However, it remains a big challenge to construct NDDSs that can overcome all the barriers at the same time. Here, we develop zwitterionic temperature/redox-sensitive nanogels loaded with near-infrared (NIR) dye Indocyanine green (ICG) and anticancer drug doxorubicin (I/D@NG)...
July 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28663143/oxygen-self-enriched-nanoparticles-functionalized-with-erythrocyte-membranes-for-long-circulation-and-enhanced-phototherapy
#17
Hao Ren, Jiaqi Liu, Yuqin Li, Haoran Wang, Sizhan Ge, Ahu Yuan, Yiqiao Hu, Jinhui Wu
In recent years, indocyanine green (ICG) encapsulated in different kinds of nano-carriers have been developed to overcome its short lifetime in vivo and non-selectivity in cancer cells. However, these nanoparticles are still easily recognized and captured by the reticuloendothelial system (RES) and the low singlet oxygen quantum (0.08) of ICG inevitably leads to a limited efficacy of phototherapy. To overcome these limitations, a novel oxygen self-enriched biomimetic red blood cell (RBC) was developed by cloaking albumin nanoparticles which contained ICG and perfluorocarbon (PFC) with RBC membranes...
June 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28663087/superiority-of-aromatase-inhibitor-and-cyclooxygenase-2-inhibitor-combined-delivery-hyaluronate-targeted-versus-pegylated-protamine-nanocapsules-for-breast-cancer-therapy
#18
Ahmed O Elzoghby, Shaimaa K Mostafa, Maged W Helmy, Maha A ElDemellawy, Salah A Sheweita
Despite several reports have revealed the beneficial effect of co-administration of COX-2 inhibitors with aromatase inhibitors in managing postmenopausal breast cancer; no nanocarriers for such combined delivery have been developed till now. Therefore, protamine nanocapsules (PMN-NCs) have been developed to co-deliver letrozole (LTZ) that inhibits aromatase-mediated estrogen biosynthesis and celecoxib (CXB) that synergistically inhibits aromatase expression. Inspired by the CD44-mediated tumor targeting ability of hyaluronate (HA), we developed HA-coated PMN-NCs (HA-NCs) via electrostatic layer-by-layer assembly...
June 27, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28662392/mc3t3-e1-pre-osteoblast-response-and-differentiation-after-graphene-oxide-nanosheet-uptake
#19
Mónica Cicuéndez, Virgília S Silva, María J Hortigüela, M Concepción Matesanz, Mercedes Vila, M Teresa Portolés
Nano-graphene oxide (GO) and its functionalized derivatives have aroused a great interest for drug delivery, tissue engineering and photothermal cancer therapy, but their biocompatibility has not yet been fully assessed. The aim of the present study was to evaluate the proliferation and differentiation of MC3T3-E1 pre-osteoblasts after the uptake of GO nanosheets (c.a. 400nm), functionalized with poly(ethylene glycol-amine) (PEG) and labelled with fluorescein isothiocyanate (FITC). Significant proliferation decrease and apoptosis increase were observed 3days after incorporation of FITC-PEG-GO by MC3T3-E1 cells...
June 20, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28648785/lc-ms-bioanalysis-of-trastuzumab-and-released-emtansine-using-nano-surface-and-molecular-orientation-limited-nsmol-proteolysis-and-liquid-liquid-partition-in-plasma-of-trastuzumab-emtansine-treated-breast-cancer-patients
#20
Noriko Iwamoto, Akihiko Shimomura, Kenji Tamura, Akinobu Hamada, Takashi Shimada
Antibody-drug conjugates (ADCs) consist of monoclonal antibody and cytotoxic drugs covalently attached via stable crosslinkers, and are prospective antibody drugs for cancer therapy. To cover the overall pharmacokinetic understanding of ADCs, both the antibody and the released drugs are necessary for practical clinical observation. The nano-surface and molecular-orientation limited (nSMOL) proteolysis is a universal approach for antibody bioanalysis that enable Fab-selective proteolysis, which maintains antibody sequence specificity while decreasing excess analyte peptides...
June 19, 2017: Journal of Pharmaceutical and Biomedical Analysis
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