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Cancer therapy nano

Omkara Swami Muddineti, Preeti Kumari, Balaram Ghosh, Swati Biswas
PURPOSE: Transferrin receptor (TfR) is up-regulated in various malignant tumors not only to meet the iron requirement, but also to increase the cell survival via participation in various cellular signaling pathways. Here we explored transferrin as ligand for Poly(ethylene Glycol) (PEG)-ylated vitamin-E/lipid (PE) core micelles (VPM). METHODS: Transferrin modified polymer was synthesized and drug loaded micelles were evaluated in 2D Hela and HepG2 cancer cells for cellular uptake and cytotoxicity and in 3D Hela spheroids for growth inhibition, uptake and penetration studies...
March 14, 2018: Pharmaceutical Research
Katyayani Tatiparti, Samaresh Sau, Kaustubh A Gawde, Arun K Iyer
Triple negative breast cancer (TNBC) is a difficult to treat disease due to the absence of the three unique receptors estrogen, progesterone and herceptin-2 (HER-2). To improve the current therapy and overcome the resistance of TNBC, there is unmet need to develop an effective targeted therapy. In this regard, one of the logical and economical approaches is to develop a tumor hypoxia-targeting drug formulation platform for selective delivery of payload to the drug-resistant and invasive cell population of TNBC tumors...
March 13, 2018: International Journal of Molecular Sciences
Zhao Xiaoxiong, Wang Junmei, Song Yujun, Xinhua Chen
A new methodology has been developed with conjugating nanoparticles (NPs) with an active ingredient of Chinese herbs for nanomedicines with auto-targeting and enhanced magnetic resonance imaging (MRI) for liver cancer therapy. Fe@Fe3 O4 NPs are first synthesized via the programmed microfluidic process, whose surfaces are first modified with -NH2 groups using a silane coupling technique that uses (3-aminopropyl) trimethoxysilane (APTMS) as the coupling reagent and are subsequently activated by the bifunctional amine-active cross-linker (e...
March 12, 2018: Drug Development and Industrial Pharmacy
Yanxue Liu, Kefeng Liu, Xiaomin Li, Shangzhen Xiao, Dan Zheng, Pengbo Zhu, Chunxiao Li, Jing Liu, Jing He, Jiandu Lei, Luying Wang
The application of non-toxic carriers to increase drug loading, multi-drug delivery, and extremely small size of nano-drugs to construct a tremendous transmission system is the goal for all researchers to be pursued. The proposal of natural pectin nano-platform for delivery of multiple drugs is critical for biomedical research, especially a particle size of below 100nm with high yield. Here we design a new core-shell structure pectin-eight-arm polyethylene glycol-ursolic acid/hydrooxycampothecin nanoparticle (Pec-8PUH NPs) through a special self-assembly method for stabilizing and dispersing particles, improving water-solubility, and achieving drug controlled release...
May 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Tian Zhou, Wenbin Cai, Hengli Yang, Huizhong Zhang, Minghua Hao, Lijun Yuan, Jie Liu, Li Zhang, Yilin Yang, Xi Liu, Jianling Deng, Ping Zhao, Guodong Yang, Yunyou Duan
In vivo assessment of apoptotic response to cancer therapy is believed to be very important for optimizing management of treatment. However, few noninvasive strategies are currently available to monitor the therapeutic response in vivo. Ultrasonography has been used to detect apoptotic cell death in vivo, but a high-frequency transducer is needed. Fortunately, the capability of ultrasound contrast agents (UCAs) to exit the leaky vasculature of tumors enables ultrasound-targeted imaging of molecular events in response to cancer therapy...
March 6, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Peiqi Zhao, Lanfang Li, Shiyong Zhou, Lihua Qiu, Zhengzi Qian, Xianming Liu, Xuchen Cao, Huilai Zhang
Multidrug resistance (MDR) has become a very serious problem in cancer therapy. To effectively reverse MDR in tumor treatments, a new pH-sensitive nano drug delivery system (NDDS) composed of mesoporous silica nanoparticles (MSNs) and d-a-tocopheryl poly-ethylene glycol 1000 succinate (TPGS) copolymers was synthesized to deliver doxorubicin (DOX) into drug-resistant breast cancer cell line (MCF-7/ADR). DOX@MSNs-TPGS were characterized to have a single peak size distribution, high DOX loading efficiency and a pH-dependent drug release profile...
March 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Dandan Zheng, Jinglong Wang, Shengrong Guo, Zhongxi Zhao, Feihu Wang
BACKGROUND: Nanoparticles play an important role in the area of drug delivery and have been applied in lung cancer treatments for the purposes of controlled release and cancer cell targeting. METHOD: A review covering various nanoparticle formulations for lung cancer therapy is presented. The pharmacodynamic models for evaluating anti-lung cancer drugs are summarized upon drug administration routes. Moreover, the current clinical applications of nano-drugs for lung cancer treatments are also reviewed, including the administration routes, dose forms, and clinical trials...
March 5, 2018: Current Drug Metabolism
Xiaoyan Yang, Gongyuan Liu, Yunhao Shi, Wei Huang, Jinjun Shao, Xiaochen Dong
Black phosphorus (BP), emerging as a new member of two-dimensional nanomaterials, has attracted growing research interests for its amazing photoelectric properties and promising application in electronic devices. Recently, BP has been confirmed to be a desirable candidate for phototherapy against cancer, including photothermal therapy (PTT) and photodynamic therapy (PDT). By regulating the number of layers, the bandgap of BP nanosheets (NSs) can be finely tuned to present near infrared light triggered phototherapeutic behaviors...
March 5, 2018: Nanotechnology
Yun-Jung Choi, Sangiliyandi Gurunathan, Jin-Hoi Kim
The use of graphene to target and eliminate cancer stem cells (CSCs) is an alternative approach to conventional chemotherapy. We show the biomolecule-mediated synthesis of reduced graphene oxide-silver nanoparticle nanocomposites (rGO-Ag) using R-phycoerythrin (RPE); the resulting RPE-rGO-Ag was evaluated in human ovarian cancer cells and ovarian cancer stem cells (OvCSCs). The synthesized RPE-rGO-Ag nanocomposite (referred to as rGO-Ag) was characterized using various analytical techniques. rGO-Ag showed significant toxicity towards both ovarian cancer cells and OvCSCs...
March 1, 2018: International Journal of Molecular Sciences
Po Li, Yue Yan, Binlong Chen, Pan Zhang, Siling Wang, Jing Zhou, Haiming Fan, Yiguang Wang, Xiaonan Huang
In recent years, multifunctional nanoparticles have attracted much research interest in various biomedical applications such as biosensors, diagnosis, and drug delivery systems. In this study, we report an NIR imaging diagnosis and therapy nanoplatform which is developed by complexing upconversion nanoparticles (UCNP@OA) NaLuF4 :Er3+ ,Yb3+ with nanographene oxide (NGO). The obtained nanocomposites UCNP@NGO showed excellent stability and low cell toxicity, which not only acted as upconversion luminescence (UCL) probes for tumor imaging, but also served as therapy agents by converting laser energy into thermal energy for photothermal therapy (PTT) with high photothermal conversion efficiency...
March 1, 2018: Biomaterials Science
Le-Le Zhou, Qun Guan, Yan-An Li, Yang Zhou, Yu-Bin Xin, Yu-Bin Dong
Herein, we report an iodine-attached Zn(II)-porphyrinic dicarboxylic building block (ZnDTPP-I2 -2H, 1) that can be introduced into UiO-66 NMOF via one-pot synthetic approach to generate a new ZnDTPP-I2 doped UiO-66 type nano metal-organic framework (NMOF) of ZnDTPP-I2 ⊂UiO-66 (2). Compared to its homologous iodine-free NMOF of ZnDTPP⊂UiO-66 (4), ZnDTPP-I2 ⊂UiO-66 (2) with heavy iodine atoms is a more effective nanosized photosensitizer for singlet oxygen generation under physiological conditions. As expected, 2 displayed a high photodynamic therapy efficacy for treatment of liver cancer cells in vitro...
February 28, 2018: Inorganic Chemistry
Yugui Tao, Longlong Zhu, Yunayuan Zhao, Xuan Yi, Longbao Zhu, Fei Ge, Xiaozhou Mou, Lei Chen, Liang Sun, Kai Yang
While radiotherapy (RT) is commonly used in clinics for cancer treatment, the therapeutic efficiency is not satisfactory owing to the existence of the hypoxic tumor microenvironment which seriously affects the efficiency of RT. Herein, we design polyethylene glycol (PEG)-modified reduced nano-graphene oxide-manganese dioxide (rGO-MnO2 -PEG) nanocomposites to trigger oxygen generation from H2 O2 to reduce the tumor hypoxic microenvironments. We use the radioisotope,131 I labeled rGO-MnO2 -PEG nanocomposites as therapeutic agents for in vivo tumor radioisotope therapy (RIT), achieving excellent tumor killing and further enhancing the therapeutic efficiency of RIT...
February 28, 2018: Nanoscale
Elham Zeinizade, Mousa Tabei, Ali Shakeri-Zadeh, Habib Ghaznavi, Neda Attaran, Ali Komeili, Behafarid Ghalandari, Shayan Maleki, S Kamran Kamrava
In this study, we explained in detail a targeted nano-photo-thermal therapy (NPTT) method to induce selective apoptosis in cancer cells. Folate-conjugated gold nanoparticles (F-AuNPs) were synthesized by tailoring the surface of AuNPs with folic acid to enhance the specificity of NPTT. KB cancer cells, as a folate receptor over-expressing cell line, and L929 normal cells with low level of folate receptors were incubated with the synthesized F-AuNPs and then irradiated with various laser intensities and exposure durations...
February 27, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Filipe Leal Portilho, Edward Helal-Neto, Santiago Sánchez Cabezas, Suyene Rocha Pinto, Sofia Nascimento Dos Santos, Lorena Pozzo, Félix Sancenón, Ramón Martínez-Máñez, Ralph Santos-Oliveira
Cancer is responsible for more than 12% of all causes of death in the world, with an annual death rate of more than 7 million people. In this scenario melanoma is one of the most aggressive ones with serious limitation in early detection and therapy. In this direction we developed, characterized and tested in vivo a new drug delivery system based on magnetic core-mesoporous silica nanoparticle that has been doped with dacarbazine and labelled with technetium 99 m to be used as nano-imaging agent (nanoradiopharmaceutical) for early and differential diagnosis and melanoma by single photon emission computed tomography...
February 27, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Leilei Shi, Li Xu, Chenwei Wu, Bai Xue, Xin Jin, Jiapei Yang, Xinyuan Zhu
Recent years have witnessed the great contributions that drug combination therapy has made for enhanced cancer therapy. However, due to the complicated pharmacokinetics of combined drug formulations, the majority of combination strategies show severe adverse effects at high dosage and poor bio-distribution in vivo. To overcome these deficiencies and achieve enhanced cancer therapy, we put forward a method to construct a smart albumin-based nano-platform, denoted as K237-HSA-DC, for co-delivery of Cyclooxygenase-2 (COX-2) inhibitor (celecoxib) and chemotherapeutic agent (doxorubicin, DOX)...
February 26, 2018: ACS Applied Materials & Interfaces
Shu Yao, Li Li, Xuan-Tao Su, Kai Wang, Zai-Jun Lu, Cun-Zhong Yuan, Jin-Bo Feng, Shi Yan, Bei-Hua Kong, Kun Song
BACKGROUND: Ovarian cancer is the most leading cause of death and the third most common gynecologic malignancy in women. Traditional chemotherapy has inevitable drawbacks of nonspecific tumor targeting, high toxicity, and poor therapeutic efficiency. In order to overcome such shortcomings, we prepared a novel nano-carrier drug-delivery system to enhance the anti-tumor efficiency. METHODS: In vitro characterizations of nano-carriers were determined by TEM, DLS. Cell viability was measured by MTT method...
February 26, 2018: Journal of Experimental & Clinical Cancer Research: CR
Mohammed A Kassem, Mohamed A Megahed, Sherif K Abu Elyazid, Fathy I Abd-Allah, Tamer M Abdelghany, Ahmed M Al-Abd, Khalid M El-Say
Serious adverse effects and low selectivity to cancer cells are the main obstacles of long term therapy with Tamoxifen (Tmx). This study aimed to develop Tmx-loaded span-based nano-vesicles for delivery to malignant tissues with maximum efficacy. The effect of three variables on vesicle size (Y1 ), zeta potential (Y2 ), entrapment efficiency (Y3 ) and the cumulative percent release after 24 h (Y4 ) were optimized using Box-Behnken design. The optimized formula was prepared and tested for its stability in different storage conditions...
February 22, 2018: AAPS PharmSciTech
Santosh K Misra, Taylor L Kampert, Dipanjan Pan
Pathogenesis of many cancer is driven by the Myc oncoprotein, its dimerization with Max, and the binding of this heterodimer to E-Boxes of target genes. The systemic effectiveness of potent small molecule inhibitors of Myc-Max dimerization has been lim-ited by poor bioavailability, rapid metabolism, and inadequate target site penetration. The potential of gene therapy for target-ing Myc can be fully realized by successful synthesis of a smart cargo. We developed a 'nuclein' type nanoparticle "siNozyme" (45±5 nm) from nano-assembly of pamitoyl-bio-conjugated acetyl co-enzyme-A for stable incorporation of chemotherapeutics and biologics to achieve remarkable growth inhibition of human melanoma...
February 21, 2018: Bioconjugate Chemistry
Arif Gulzar, Jiating Xu, Dan Yang, Liangge Xu, Fei He, Shili Gai, Piaoping Yang
NIR light-induced imaging-guided cancer therapy is an encouraging route in the cancer theranostic field. Herein, we describe a novel nanoscale proposal, which is established by covalently implanting core-shell structured upconversion nanoparticles (UCNPs) with nanographene oxide (NGO) by a process utilizing polyethylene glycol (PEG), and consequently loading Chlorin e6 (Ce6) onto the surface of NGO. The acquired NGO-UCNP-Ce6 (NUC) nanocomposites can not only be employed as upconversion luminescence (UCL) imaging probes of cells and whole-body animals with high contrast for diagnosis, but also can generate reactive oxygen species (ROS) under 808 nm light excitation for photodynamic therapy (PDT); over and above, they can swiftly and proficiently translate the 808 nm photon into thermal energy for photothermal therapy (PTT)...
February 20, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Shunxiu Cao, Jiamin Guo, Yujing He, Murad Alahdal, Shanshan Tang, Yuekui Zhao, Zhaocong Yang, Huashan Gao, Wenjun Hu, Hulin Jiang, Lianju Qin, Liang Jin
The main challenge of anticancer drugs is poor tumor targeting. Now cellular carriers are widely investigated to deliver anticancer agents. As an ideal cellular candidate, human umbilical cord derived mesenchymal stem cells (hUC-MSCs) possess inherent tropism potential to tumor. Here, we constructed hUC-MSCs carrying transferrin-inspired-nanoparticles that contain doxorubicin(hUC-MSCs-Tf-inspired-NPs) to achieve enhanced anti-tumor efficacy and made an evaluation. Results represented that hUC-MSCs-Tf-inspired-NPs not only exhibit the controlled-release property of Tf-inspired-NPs, but also integrate tumor tropism and penetrative abilities of MSCs...
February 19, 2018: Artificial Cells, Nanomedicine, and Biotechnology
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