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https://www.readbyqxmd.com/read/27926458/changes-in-relative-and-absolute-concentrations-of-plasma-phospholipid-fatty-acids-observed-in-a-randomized-trial-of-omega-3-fatty-acids-supplementation-in-uganda
#1
Xiaoling Song, Pho Diep, Jeannette M Schenk, Corey Casper, Jackson Orem, Zeina Makhoul, Johanna W Lampe, Marian L Neuhouser
Expressing circulating phospholipid fatty acids (PLFAs) in relative concentrations has some limitations: the total of all fatty acids are summed to 100%; therefore, the values of individual fatty acid are not independent. In this study we examined if both relative and absolute metrics could effectively measure changes in circulating PLFA concentrations in an intervention trial. 66 HIV and HHV8 infected patients in Uganda were randomized to take 3g/d of either long-chain omega-3 fatty acids (1856mg EPA and 1232mg DHA) or high-oleic safflower oil in a 12-week double-blind trial...
November 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27909717/restorative-effects-of-hydroxysafflor-yellow%C3%A2-a-on-hepatic-function-in-an-experimental-regression-model-of-hepatic-fibrosis-induced-by-carbon-tetrachloride
#2
Yanuo Li, Yan Shi, Yan Sun, Luying Liu, Xianyong Bai, Dong Wang, Hongxing Li
Hepatic fibrosis is a reversible pathological process, in which fibrotic tissue is excessively deposited in the liver during the repair process that follows hepatic injury. Early prevention or treatment of hepatic fibrosis has great significance on the treatment of chronic hepatic diseases. Hydroxysafflor yellow A (HSYA) is a water-soluble monomer extracted from safflower, which serves numerous pharmacological roles. However, it remains to be elucidated how HSYA regulates hepatic fibrogenesis. The aim of the present study was to reveal the possible mechanisms underlying the effects of HSYA on the prevention and treatment of hepatic fibrosis...
November 24, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27863203/safflower-catharmus-tinctorius-l-oil-supplementation-in-overnourished-rats-during-early-neonatal-development-effects-on-heart-and-liver-function-in-the-adult
#3
Laís Ribeiro Costa, Patrícia Cavalcanti Macêdo, Janatar Stella Vasconcelos de Melo, Cristiane Moura Freitas, Aiany Simoes Alves, Humberto de Moura Barbosa, Eduardo Lira, Mariana Pinheiro Fernandes, Manuella Batista-de-Oliveira-Hornsby, Claudia Lagranha
Carthamus tinctorius L. (common name: safflower) is an herb whose extracted oil (safflower oil) has been employed in both alternative and conventional medicine in the treatment of disease. Overnutrition during early postnatal life can increase the lifetime risk of obesity and metabolic syndrome. Here we investigate the effect of safflower oil supplementation given during a critical early developmental stage on the eventual occurrence of metabolic disease in overnourished rats. Groups of overnourished or adequately nourished rats were randomly assigned into 2 additional groups for supplementation with either safflower oil (SF) or vehicle for 7 to 30 days...
December 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27856001/enteral-high-fat-polyunsaturated-fatty-acid-blend-alters-the-pathogen-composition-of-the-intestinal-microbiome-in-premature-infants-with-an-enterostomy
#4
Noelle Younge, Qing Yang, Patrick C Seed
OBJECTIVE: To determine the effect of enteral fish oil and safflower oil supplementation on the intestinal microbiome in infants with an enterostomy born premature. STUDY DESIGN: Infants with an enterostomy born premature were randomized to receive early enteral supplementation with a high-fat polyunsaturated fatty acid (HF-PUFA) blend of fish oil and safflower oil vs standard nutritional therapy. We used 16S rRNA gene sequencing for longitudinal profiling of the microbiome from the time of study entry until bowel reanastomosis...
November 15, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27852617/sex-differences-in-the-effect-of-fish-oil-supplementation-on-the-adaptive-response-to-resistance-exercise-training-in-older-people-a-randomized-control-trial
#5
Mariasole Da Boit, Rachael Sibson, Selvaraj Sivasubramaniam, Judith R Meakin, Carolyn A Greig, Richard M Aspden, Frank Thies, Stewart Jeromson, D Lee Hamilton, John R Speakman, Catherine Hambly, Arduino A Mangoni, Thomas Preston, Stuart R Gray
BACKGROUND: Resistance exercise increases muscle mass and function in older adults, but responses are attenuated compared with younger people. Data suggest that long-chain n-3 polyunsaturated fatty acids (PUFAs) may enhance adaptations to resistance exercise in older women. To our knowledge, this possibility has not been investigated in men. OBJECTIVE: We sought to determine the effects of long-chain n-3 PUFA supplementation on resistance exercise training-induced increases in muscle mass and function and whether these effects differ between older men and women...
November 16, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27827969/comparative-analysis-of-the-effects-of-hydroxysafflor-yellow-a-and-anhydrosafflor-yellow-b-in-safflower-series-of-herb-pairs-using-prep-hplc-and-a-selective-knock-out-approach
#6
Cheng Qu, Lin-Yan Wang, Wen-Tao Jin, Yu-Ping Tang, Yi Jin, Xu-Qin Shi, Li-Li Shang, Er-Xin Shang, Jin-Ao Duan
The flower of Carthamus tinctorius L. (Carthami Flos, safflower), important in traditional Chinese medicine (TCM), is known for treating blood stasis, coronary heart disease, hypertension, and cerebrovascular disease in clinical and experimental studies. It is widely accepted that hydroxysafflor yellow A (HSYA) and anhydrosafflor yellow B (ASYB) are the major bioactive components of many formulae comprised of safflower. In this study, selective knock-out of target components such as HSYA and ASYB by using preparative high performance liquid chromatography (prep-HPLC) followed by antiplatelet and anticoagulation activities evaluation was used to investigate the roles of bioactive ingredients in safflower series of herb pairs...
November 6, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27807441/utilization-of-molecular-phenotypic-and-geographical-diversity-to-develop-compact-composite-core-collection-in-the-oilseed-crop-safflower-carthamus-tinctorius-l-through-maximization-strategy
#7
Shivendra Kumar, Heena Ambreen, Murali T Variath, Atmakuri R Rao, Manu Agarwal, Amar Kumar, Shailendra Goel, Arun Jagannath
Safflower (Carthamus tinctorius L.) is a dryland oilseed crop yielding high quality edible oil. Previous studies have described significant phenotypic variability in the crop and used geographical distribution and phenotypic trait values to develop core collections. However, the molecular diversity component was lacking in the earlier collections thereby limiting their utility in breeding programs. The present study evaluated the phenotypic variability for 12 agronomically important traits during two growing seasons (2011-12 and 2012-13) in a global reference collection of 531 safflower accessions, assessed earlier by our group for genetic diversity and population structure using AFLP markers...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27804268/effects-of-canola-and-high-oleic-acid-canola-oils-on-abdominal-fat-mass-in-individuals-with-central-obesity
#8
Xiaoran Liu, Penny M Kris-Etherton, Sheila G West, Benoît Lamarche, David J A Jenkins, Jennifer A Fleming, Cindy E McCrea, Shuaihua Pu, Patrick Couture, Philip W Connelly, Peter J H Jones
OBJECTIVE: To determine the effect of diets low in saturated fatty acids and high in monounsaturated fatty acids (MUFA) or polyunsaturated fatty acids on body composition in participants at risk for metabolic syndrome (MetS). METHODS: This study was a randomized, crossover, controlled feeding study. Participants (n = 101, ages 49.5 ± 1.2, BMI 29.4 ± 0.4 kg/m(2) ) were randomized to five isocaloric diets containing treatment oils: Canola, CanolaOleic, CanolaDHA, Corn/Safflower, and Flax/Safflower...
November 2016: Obesity
https://www.readbyqxmd.com/read/27777380/aging-dysregulates-d-and-e-series-resolvins-to-modulate-cardiosplenic-and-cardiorenal-network-following-myocardial-infarction
#9
Ganesh V Halade, Vasundhara Kain, Laurence M Black, Sumanth D Prabhu, Kevin A Ingle
Post-myocardial infarction (MI), overactive inflammation is the hallmark of aging, however, the mechanism is unclear. We hypothesized that excess influx of omega 6 fatty acids may impair resolution, thus impacting the cardiosplenic and cardiorenal network post-MI. Young and aging mice were fed on standard lab chow (LC) and excess fatty acid (safflower oil; SO)-enriched diet for 2 months and were then subjected to MI surgery. Despite similar infarct areas and left ventricle (LV) dysfunction post-MI, splenic mass spectrometry data revealed higher levels of arachidonic acid (AA) derived pro-inflammatory metabolites in young-SO, but minimal formation of docosanoids, D- and E- series resolvins in SO-fed aged mice...
October 18, 2016: Aging
https://www.readbyqxmd.com/read/27776431/safflower-yellow-prevents-pulmonary-metastasis-of-breast-cancer-by-inhibiting-tumor-cell-invadopodia
#10
Huiying Fu, Renjie Wu, Yuanyuan Li, Lizong Zhang, Xiaofang Tang, Jue Tu, Weimin Zhou, Jianchao Wang, Qiyang Shou
Carthamus tinctorius L. is a traditional Chinese medicine that activates blood circulation and dissipates blood stasis, and has been extensively used as antitumor treatment in a clinical setting in single or in compound preparation form. However, empirical evidence and a better understanding of the possible mechanisms involved are still required. Here, we investigated the role of safflower yellow (SY), the active ingredient of C. tinctorius, in the pulmonary metastasis of breast cancer, and the underlying mechanism of action...
October 25, 2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27773731/effects-of-dietary-administration-of-rose-hip-and-safflower-on-growth-performance-haematological-biochemical-parameters-and-innate-immune-response-of-beluga-huso-huso-linnaeus-1758
#11
Hadiseh Dadras, Mohammad Reza Hayatbakhsh, William L Shelton, Amin Golpour
The aim of this study was to investigate effects of two dietary medicinal herbs, Rose hip (Rosa canina) and Safflower (Carthamus tinctorius) supplementation on growth performance, haematological, biochemical parameters and innate immune response of in juvenile beluga, Huso huso. Fish (26.3 ± 0.4 g) were allocated into 15 tanks (20 fish per tank) and triplicate groups were fed a control diet or diets containing 1% and 2% of medicinal herbs, respectively. Feed conversion ratio (FCR), specific growth rate (SGR) and condition factor (CF) did not show significant differences (P > 0...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27725480/volatile-oxidation-compounds-and-stability-of-safflower-sesame-and-canola-cold-pressed-oils-as-affected-by-thermal-and-microwave-treatments
#12
Mustafa Kiralan, Mohamed Fawzy Ramadan
The goal of this study was to investigate the effect of heating and microwave treatment on the levels of volatile oxidation products and the stability of safflower (Carthamus tinctorius L.), sesame (Sesamum indicum) and canola (Brassica napus L.) cold-pressed oils. Cold-pressed oils were subjected to conventional heating (oven test) using air-forced oven at 60°C and microwave heating for 2 and 4 min. The changes in conjugated diene (CD) and conjugated triene (CT) values were monitored during treatments. As expected, heating generates an increase in CD and CT values...
2016: Journal of Oleo Science
https://www.readbyqxmd.com/read/27721891/corrigendum-to-the-value-of-safflower-yellow-injection-for-the-treatment-of-acute-cerebral-infarction-a-randomized-controlled-trial
#13
Le-Jun Li, Yu-Mei Li, Ben-Yu Qiao, Shan Jiang, Xin Li, Hong-Ming Du, Peng-Cheng Han
[This corrects the article DOI: 10.1155/2015/478793.].
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27714300/4-4-bismoschamine-biomimetic-synthesis-and-evidence-to-support-structural-equivalency-to-montamine
#14
Kaitlin G Henry, Lachlan M Blair, Jonathan Sperry, Elizabeth A Colby Davie
The dimeric natural product montamine was originally reported as two N-feruloylserotonin (moschamine) units linked by a nitrogen-nitrogen bond, but our recent synthesis of this symmetrical diacyl hydrazide structure revealed this to be incorrect. We subsequently hypothesized that the moschamine subunits were linked through the indole C4 site and that montamine was structurally identical to 4,4'-bismoschamine, a known natural product present in safflower oil. However, given that authentic samples of both montamine and 4,4'-bismoschamine were unavailable and that the NMR data for the natural products were recorded in different solvents, we were unable to unequivocally prove this hypothesis...
September 21, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27713966/hydroxysafflor-yellow-a-inhibits-il-1%C3%AE-induced-release-of-il-6-il-8-and-mmp-1-via-suppression-of-erk-nf-%C3%AE%C2%BAb-and-ap-1-signaling-in-sw982-human-synovial-cells
#15
Bin-Feng Cheng, Yao-Xin Gao, Jun-Jiang Lian, Dan-Dan Guo, Lei Wang, Mian Wang, Hai-Jie Yang, Zhi-Wei Feng
Hydroxysafflor yellow A (HSYA), the main active ingredient in medical and edible dual purpose plant safflower, is reported to have multiple bioactivities. In the present study, the anti-inflammatory effects of HSYA and the underlying mechanisms were investigated in interleukin (IL)-1β-induced SW982 human synovial cells. The cells were pretreated with HSYA at various concentrations (2.5, 10 and 40 μM) followed by IL-1β (10 ng mL(-1)) stimulation. HSYA significantly inhibited the expression of IL-6, IL-8 and matrix metalloproteinase (MMP)-1 in IL-1β-stimulated SW982 cells...
October 7, 2016: Food & Function
https://www.readbyqxmd.com/read/27688126/brain-omega-3-polyunsaturated-fatty-acids-modulate-microglia-cell-number-and-morphology-in-response-to-intracerebroventricular-amyloid-%C3%AE-1-40-in-mice
#16
Kathryn E Hopperton, Marc-Olivier Trépanier, Vanessa Giuliano, Richard P Bazinet
BACKGROUND: Neuroinflammation is a proposed mechanism by which Alzheimer's disease (AD) pathology potentiates neuronal death and cognitive decline. Consumption of omega-3 polyunsaturated fatty acids (PUFA) is associated with a decreased risk of AD in human observational studies and exerts protective effects on cognition and pathology in animal models. These fatty acids and molecules derived from them are known to have anti-inflammatory and pro-resolving properties, presenting a potential mechanism for these protective effects...
September 29, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27672559/behavioral-and-omics-analyses-study-on-potential-involvement-of-dipeptide-balenine-through-supplementation-in-diet-of-senescence-accelerated-mouse-prone-8
#17
Nobuhiro Wada, Satoru Yamanaka, Junko Shibato, Randeep Rakwal, Satoshi Hirako, Yuzuru Iizuka, Hyounju Kim, Akiyo Matsumoto, Ai Kimura, Fumiko Takenoya, Genta Yasunaga, Seiji Shioda
This study investigates effects of dipeptide balenine, as a major component of whale meat extract (hereafter, WME), supplementation on senescence-accelerated mouse prone 8 (SAMP8), an Alzheimer's disease (AD) model at level of learning and memory formation and brain expression profiles genome-wide in brain. Mice fed experimental balenine (+ WME) supplemented diet for 26 weeks were subjected to four behavioral tests - open field, Y-maze, new object recognition, and water-filled multiple T-maze - to examine effects on learning and memory...
December 2016: Genomics Data
https://www.readbyqxmd.com/read/27654062/circulating-free-fatty-acids-inhibit-food-intake-in-an-oleate-specific-manner-in-rats
#18
Young Taek Oh, Hyun Hee Oh, Anh-Khoi Nguyen, Cheol Soo Choi, Jang H Youn
Previous rodent studies showed that when injected into the brain, free fatty acids (FFAs) reduced food intake in an oleate-specific manner. The present study was performed to test whether food intake is regulated by circulating FFAs in an oleate-specific manner. Male Wistar rats received an intravenous infusion of olive, safflower, or coconut oil (100mg/h), together with heparin, to raise circulating oleate, linoleate, or palmitate, respectively, and their effects on overnight food intake were evaluated. Compared to other oils, olive oil infusion showed a significantly greater effect to reduce food intake (P<0...
September 18, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27632920/defatted-safflower-seed-extract-inhibits-adipogenesis-in-3t3-l1-preadipocytes-and-improves-lipid-profiles-in-c57bl-6j-ob-ob-mice-fed-a-high-fat-diet
#19
Eun-Young Hwang, Mi-Hee Yu, Yeon-Seop Jung, Sam-Pin Lee, Jin Han Shon, Syng-Ook Lee
In the present study, we hypothesized that defatted safflower seed which is known to be rich in polyphenols might influence adipogenesis and obesity-related disorders, and therefore the anti-adipogenic and hypolipidemic effects of ethanol extract from defatted safflower (Cathamus tinctorius L.) seeds (CSE) were investigated both in cultured 3T3-L1 preadipocytes and in C57BL/6J ob/ob mice fed a high-fat diet. CSE inhibited adipocyte differentiation of 3T3-L1 preadipocytes and decreased expression of the adipogenic transcription factors, SREBP1c and PPARγ, and their target genes...
September 2016: Nutrition Research
https://www.readbyqxmd.com/read/27624481/guhong-injection-protects-against-focal-cerebral-ischemia-reperfusion-injury-via-anti-inflammatory-effects-in-rats
#20
Jinchao Ai, Haitong Wan, Mingchun Shu, Huifen Zhou, Tao Zhao, Wei Fu, Yu He
Guhong injection (GHI), composed of aceglutamide and safflower aqueous extract, has been used clinically for the treatment of cerebrovascular diseases such as cerebral embolism, hemorrhage and mental deterioration. In this paper, we reported the results of the first study on the anti-inflammatory effects of GHI in murine focal cerebral ischemia-reperfusion (I/R) injury. Adult male SD rats were randomly divided into six groups: Sham group, I/R group, GHI-L group (2.5 mL/kg), GHI-M group (5 mL/kg), GHI-H group (10 mL/kg) and Nimodipine group...
September 13, 2016: Archives of Pharmacal Research
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