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https://www.readbyqxmd.com/read/29775616/amelioration-of-uvb-induced-oxidative-stress-and-inflammation-in-fat-1-transgenic-mouse-skin
#1
Hye-Won Yum, Seong Hoon Kim, Jing X Kang, Young-Joon Surh
ω-3 polyunsaturated fatty acids (PUFAs), which are abundant in some fish oils, are known to scavenge lipid peroxyl radicals and increase host immunoresponsiveness. As UVB-induced oxidative stress and inflammation have been implicated in apoptotic cell death, this study was designed to investigate the anti-inflammatory, anti-oxidative, and anti-apoptotic capacity of fat-1 transgenic mice capable of converting ω-6 to ω-3 PUFAs. Wild-type (WT) C57BL/6 mice and fat-1 mice were maintained on the AIN-93 diet supplemented with 10% safflower oil rich in ω-6 PUFAs for 5 weeks...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29752697/biofortification-of-safflower-an-oil-seed-crop-engineered-for-ala-targeting-better-sustainability-and-plant-based-omega-3-fatty-acids
#2
Arti Rani, Asha Panwar, Manjary Sathe, Karunakara Alageri Chandrashekhara, Anil Kush
Alpha-linolenic acid (ALA) deficiency and a skewed n6:n3 fatty acid ratio in the diet is a major explanation for the prevalence of cardiovascular diseases and inflammatory/autoimmune diseases. There is mounting evidence of the health benefits associated with omega-3 long chain polyunsaturated fatty acids (LC PUFA's). Although present in abundance in fish, a number of factors limit our consumption of fish based omega-3 PUFA's. To name a few, overexploitation of wild fish stocks has reduced their sustainability due to increased demand of aquaculture for fish oil and meal; the pollution of marine food webs has raised concerns over the ingestion of toxic substances such as heavy metals and dioxins; vegetarians do not consider fish-based sources for supplemental nutrition...
May 11, 2018: Transgenic Research
https://www.readbyqxmd.com/read/29729342/safflower-carthamus-tinctorius-l-polysaccharide-attenuates-cellular-apoptosis-in-steroid-induced-avascular-necrosis-of-femoral-head-by-targeting-caspase-3-dependent-signaling-pathway
#3
Daping Cui, Dewei Zhao, Benjie Wang, Baoyi Liu, Lei Yang, Hui Xie, Zihua Wang, Liangliang Cheng, Xing Qiu, Zhijie Ma, Mingyang Yu, Di Wu, Hao Long
The present study aimed to investigate the effects of a purified polysaccharide (SPS) from the safflower in a cellular model of steroid-associated necrosis of the femoral head (SANFH), which was established in primary murine osteoblasts suffering dexamethasone pretreatment. After treatment with SPS (25, 50 and 100 μg/ml), the degree of necrosis induced by dexamethasone was significantly reduced in osteoblasts as evidenced by an increase of cell viability and a decrease of apoptosis in osteoblasts. Furthermore, pretreatment with SPS (25, 50 and 100 μg/ml) significantly attenuated the activation of caspase-3 and cleavage of PARP relative to the model control cells...
May 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29700792/preventive-effect-of-shenkang-injection-against-high-glucose-induced-senescence-of-renal-tubular-cells
#4
Biqiong Fu, Jie Yang, Jia Chen, Lirong Lin, Kehong Chen, Weiwei Zhang, Jianguo Zhang, Yani He
Shenkang injection (SKI) is a classic prescription composed of Radix Astragali, rhubarb, Astragalus, Safflower, and Salvia. This treatment was approved by the State Food and Drug Administration of China in 1999 for treatment of chronic kidney diseases based on good efficacy and safety. This study aimed to investigate the protective effect of SKI against high glucose (HG)-induced renal tubular cell senescence and its underlying mechanism. Primary renal proximal tubule epithelial cells were cultured in (1) control medium (control group), medium containing 5 mmol/L glucose; (2) mannitol medium (mannitol group), medium containing 5 mmol/L glucose, and 25 mmol/L mannitol; (3) HG medium (HG group) containing 30 mmol/L glucose; (4) SKI treatment at high (200 mg/L), medium (100 mg/L), or low (50 mg/L) concentration in HG medium (HG + SKI group); or (5) 200 mg/L SKI treatment in control medium (control + SKI group) for 72 h...
April 25, 2018: Frontiers of Medicine
https://www.readbyqxmd.com/read/29674850/effect-of-dietary-oils-on-peripheral-neuropathy-related-endpoints-in-dietary-obese-rats
#5
Lawrence Coppey, Eric Davidson, Hanna Shevalye, Michael E Torres, Mark A Yorek
Purpose: This study aimed to determine the effect of dietary oils (olive, safflower, evening primrose, flaxseed, or menhaden) enriched in different mono unsaturated fatty acids or polyunsaturated fatty acids on peripheral neuropathies in diet-induced obese Sprague-Dawley rats. Materials and methods: Rats at 12 weeks of age were fed a high-fat diet (45% kcal) for 16 weeks. Afterward, the rats were fed diets with 50% of the kilocalories of fat derived from lard replaced by the different dietary oils...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29666353/inheritance-of-carthamin-and-carthamidin-in-safflower-carthamus-tinctorius-l
#6
Pooran Golkar
The safflower (Carthamus tinctorius L.) is an oil seed crop from which the flowers is used as medicine and food colorants. The present investigation was undertaken to explore gene effects for safflower's pigments in flower including carthamin and carthamidin. Six generation including P1 , P2 , F1 , F2 , BC1 and BC2 that derived from two different crosses (Mex. 2-138 (P2 ) × Wht-Esf (P1 ) and C111 (P2 ) × Wht-Esf (P1 ) were used for generation of mean analysis. The joint scaling test showed that additive [a], additive × additive [aa], and additive × dominance [ad] effects were significant for genetic control of carthamin and carthamidin in both crosses...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29660814/effects-of-cd36-genotype-on-oral-perception-of-oleic-acid-supplemented-safflower-oil-emulsions-in-two-ethnic-groups-a-preliminary-study
#7
Brenda Burgess, Melania Melis, Katelyn Scoular, Michael Driver, Karen M Schaich, Kathleen L Keller, Iole Tomassini Barbarossa, Beverly J Tepper
Previous studies demonstrate humans can detect fatty acids via specialized sensors on the tongue, such as the CD36 receptor. Genetic variation at the common single nucleotide polymorphism rs1761667 of CD36 has been shown to differentially impact the perception of fatty acids, but comparative data among different ethnic groups are lacking. In a small cohort of Caucasian and East Asian young adults, we investigated if: (1) participants could detect oleic acid (C18:1) added to safflower oil emulsions at a constant ratio of 3% (w/v); (2) supplementation of oleic acid to safflower oil emulsions enhanced perception of fattiness and creaminess; and (3) variation at rs1761667 influenced oleic acid detection and fat taste perception...
April 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29651296/association-mapping-for-important-agronomic-traits-in-safflower-carthamus-tinctorius-l-core-collection-using-microsatellite-markers
#8
Heena Ambreen, Shivendra Kumar, Amar Kumar, Manu Agarwal, Arun Jagannath, Shailendra Goel
Carthamus tinctorius L. (safflower) is an important oilseed crop producing seed oil rich in unsaturated fatty acids. Scarcity of identified marker-trait associations is a major limitation toward development of successful marker-assisted breeding programs in safflower. In the present study, a safflower panel (CartAP) comprising 124 accessions derived from two core collections was assayed for its suitability for association mapping. Genotyping of CartAP using microsatellite markers revealed significant genetic diversity indicated by Shannon information index ( H = 0...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29580528/sorting-out-the-phytoprostane-and-phytofuran-profile-in-vegetable-oils
#9
Raúl Domínguez-Perles, Ángel Abellán, Daniel León, Federico Ferreres, Alexander Guy, Camille Oger, Jean Marie Galano, Thierry Durand, Ángel Gil-Izquierdo
Phytoprostanes (PhytoPs) and phytofurans (PhytoFs) are prostaglandin-like compounds, contributing to defense signaling and prevention of cellular damage. These plant oxylipins result from autoxidation of α-linolenic acid (ALA) and have been proposed as new bioactive compounds due to their structural analogies with isoprostanes (IsoPs) and prostanoids derived from arachidonic acid in mammals, which have demonstrated diverse biological activities. The present work assesses a wide range of vegetable oils - including extra virgin olive oils (n = 7) and flax, sesame, argan, safflower seed, grapeseed, and palm oils - for their content of PhytoPs and PhytoFs...
May 2018: Food Research International
https://www.readbyqxmd.com/read/29579831/acute-liver-failure-induced-by-carthamus-tinctorius-oil-case-reports-and-literature-review
#10
E C de Ataide, S Reges Perales, M A de Oliveira Peres, L Bastos Eloy da Costa, F Quarella, F G Valerini, F Chueiri Neto, R Silveira Bello Stucchi, I de Fátima Santana Ferreira Boin
BACKGROUND: Acute liver failure (ALF) is a clinical syndrome that results from the abrupt loss of liver function in a patient without previous liver disease. The most frequent causes are viral hepatitis, drug induced, and autoimmune disease, but in 20% of cases no cause is identified. Carthamus tinctorius (safflower) oil is used as a dietary supplement for weight loss and antioxidant. There are 4 cases described in the literature of ALF induced by the use of this substance. The objective of this study was to report 3 cases of ALF treated at the Clinical Hospital of the State University of Campinas that suggest the use of C tinctorius oil as a probable etiologic factor...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29575869/volatile-oil-composition-of-i-carthamus-tinctorius-i-l-flowers-grown-in-kazakhstan
#11
Aknur Amanbekovna Turgumbayeva, Gulbaram Omargazieva Ustenova, Balakyz Kymyzgalievna Yeskalieva, Bakyt Amanullovna Ramazanova, Kairolla Duysenbayevich Rahimov, Hajiakbar Aisa, Konrad T Juszkiewicz
INTRODUCTION: <i>Carthamus tinctorius L.</i> is commonly known as Safflower. <i>C. tinctorius</i> extracts and oil are important in drug development with numerous pharmacological activities in the world. This plant is cultivated mainly for its seed which is used as edible oil. For a long time, <i>C. tinctorius</i> has been used in traditional medicines as a purgative, analgesic, antipyretic and an antidote to poisoning. It is a useful plant in painful menstrual problems, post-partum haemorrhage and osteoporosis...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29509999/seed-specific-rnai-in-safflower-generates-a-superhigh-oleic-oil-with-extended-oxidative-stability
#12
Craig C Wood, Shoko Okada, Matthew C Taylor, Amratha Menon, Anu Mathew, Darren Cullerne, Stuart J Stephen, Robert S Allen, Xue-Rong Zhou, Qing Liu, John G Oakeshott, Surinder P Singh, Allan G Green
Vegetable oils extracted from oilseeds are an important component of foods, but are also used in a range of high value oleochemical applications. Despite being biodegradable, nontoxic and renewable current plant oils suffer from the presence of residual polyunsaturated fatty acids that are prone to free radical formation that limit their oxidative stability, and consequently shelf life and functionality. Many decades of plant breeding have been successful in raising the oleic content to ~90%, but have come at the expense of overall field performance, including poor yields...
March 6, 2018: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29473916/effects-of-diets-differing-in-composition-of-18-c-fatty-acids-on-adipose-tissue-thermogenic-gene-expression-in-mice-fed-high-fat-diets
#13
Sunhye Shin, Kolapo M Ajuwon
Dietary fatty acids play important roles in the regulation of fat accumulation or metabolic phenotype of adipocytes, either as brown or beige fat. However, a systematic comparison of effects of diets with different composition of 18-C fatty acids on browning/beiging phenotype has not been done. In this study, we compared the effects of different dietary fats, rich in specific 18-carbon fatty acids, on thermogenesis and lipid metabolism. Male C57BL/6 mice were fed a control diet containing 5.6% kcal fat from lard and 4...
February 23, 2018: Nutrients
https://www.readbyqxmd.com/read/29470144/the-effect-of-mono-and-diglycerides-on-the-digestion-and-absorption-of-lutein-in-lymph-fistula-rats
#14
Patrick Tso, Mustafa Vurma, Chih-Wei Ko, Dana M Lee, Stephen DeMichele
Breastmilk lutein is better absorbed by infants than lutein delivered in infant formula. Therefore, we wish to better understand the possible absorption differences of lutein in breast milk versus infant formula by determining its bioavailability after gastric administration and whether the intestinal absorption of lutein can be improved by using new delivery vehicles. STUDY ONE compared the intestinal uptake, and the lymphatic and portal transport of lutein in conscious lymph fistula rats. Four groups of lymph and portal vein cannulated rats (n = 8-10/group) were randomized to receive via the gastric tube increasing doses (10,20,40,or 80mg/kg) of 20% lutein in safflower oil (SO) suspension to assess whether there was a saturable level of lutein that can be absorbed and transported in lymph...
February 22, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29454700/technical-note-an-in-vivo-method-to-determine-kinetics-of-unsaturated-fatty-acid-biohydrogenation-in-the-rumen
#15
M Baldin, D E Rico, M H Green, K J Harvatine
Rumen microbial biohydrogenation (BH) of unsaturated fatty acids (UFA) has been extensively studied in vitro; however, in vitro BH pathways, rates, and extents may not parallel those in vivo. The objective was to develop an assay to assess in vivo rates, pathways, and extent of BH of oleic (OA), linoleic (LA), and α-linolenic (ALA) acids. Each UFA was characterized in a separate experiment, each using 4 ruminally cannulated lactating Holstein cows. A single bolus consisting of 200 g of a UFA-oil [experiment 1 (EXP1): 87% OA sunflower, experiment 2 (EXP2): 70% LA safflower, and experiment 3 (EXP3): 54% ALA flaxseed] and 12 g of heptadecanoic acid (C17:0) was mixed into the rumen through the fistula...
May 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29446788/the-potential-role-of-herbal-products-in-the-treatment-of-parkinson-s-disease
#16
M S Amro, S L Teoh, A G Norzana, D Srijit
Parkinson's disease (PD) is a multifactorial disorder of the nervous system in which there is a progressive loss of dopaminergic neurons. There is a disturbance in the movement in PD and these include resting tremors, rigidity, bradykinesia or akinesia, disturbance, posture and freezing (motor block). The substantia nigra and other parts of the brain are commonly affected. The disorder could be related to oxidative stress and there is an important role of reactive oxygen species (ROS). A number of herbal products contain active components which are known to possess antioxidant action...
January 2018: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29431470/economic-evaluation-of-safflower-yellow-injection-for-the-treatment-of-patients-with-stable-angina-pectoris-in-china-a-cost-effectiveness-analysis
#17
Jianwei Xuan, Min Huang, Yongji Lu, Libo Tao
OBJECTIVE: The purpose of this study was to evaluate the cost-effectiveness of Safflower Yellow Injection (SYI) plus conventional treatment (SYI group) versus conventional treatment only (conventional group) for the treatment of stable angina pectoris (SAP) patients in China. METHODS: A decision-tree model was constructed and the treatment impact was estimated for up to 1 year. The data, including treatment effectiveness, episodes of angina pectoris (AP)-associated hospitalization and its in-hospital mortality, mortality rate of heart diseases, and cost of hospitalization, were obtained from literature...
February 12, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29413488/marine-fish-oil-is-more-potent-than-plant-based-n-3-polyunsaturated-fatty-acids-in-the-prevention-of-mammary-tumors
#18
Jiajie Liu, Salma A Abdelmagid, Christopher J Pinelli, Jennifer M Monk, Danyelle M Liddle, Lyn M Hillyer, Barbora Hucik, Anjali Silva, Sanjeena Subedi, Geoffrey A Wood, Lindsay E Robinson, William J Muller, David W L Ma
Marine-derived n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to inhibit mammary carcinogenesis. However, evidence regarding plant-based α-linolenic acid (ALA), the major n-3 PUFA in the Western diet, remains equivocal. The objective of this study was to examine the effect of lifelong exposure to plant- or marine-derived n-3 PUFAs on pubertal mammary gland and tumor development in MMTV-neu(ndl)-YD5 mice. It is hypothesized that lifelong exposure to n-3 PUFA reduces terminal end buds during puberty leading to delayed tumor onset, volume and multiplicity...
December 27, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29413363/safflower-n-6-and-flaxseed-n-3-high-fat-diets-differentially-regulate-hypothalamic-fatty-acid-profiles-gene-expression-and-insulin-signalling
#19
Maria Fernanda Fernandes, Maria Cristina Tache, Shannon L Klingel, Francesco Leri, David M Mutch
Polyunsaturated fatty acids (PUFA) have important signalling roles in the hypothalamus, a region of the brain that regulates whole-body energy homeostasis. While evidence suggests that high PUFA intake can impact hypothalamic activity, the underlying molecular mechanisms regulated by essential dietary n-6 and n-3 PUFA (i.e., linoleic acid and α-linolenic acid, respectively) remain poorly described in this brain region. To differentiate the roles of essential dietary PUFA on hypothalamic function, we fed male rats high-fat diets (35% kcal/d) containing either safflower (linoleic acid) or flaxseed (α-linolenic acid) oil for 2 months...
January 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29408092/topical-application-of-hydroxysafflor-yellow-a-accelerates-the-wound-healing-in-streptozotocin-induced-t1dm-rats
#20
Si-Qian Gao, Chen Chang, Xiao-Qian Niu, Long-Jian Li, Yan Zhang, Jian-Qing Gao
To investigate the effects of Hydroxysafflor Yellow A (HSYA), which is derived from safflower, on the proliferation, migration and angiogenesis of cells in vitro and its potential efficacy in vivo when topically applied to a diabetic wound. Human umbilical vein endothelial cells (HUVECs) and mouse macrophage cells (RAW264.7) were used to evaluate angiogenesis and anti-inflammatory activities, respectively. The influence of HSYA on the wound scratch assay was investigated in keratinocytes. A splinted excisional wound model in rats with TIDM induced by streptozotocin was used to assess the effects of wound healing...
March 15, 2018: European Journal of Pharmacology
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