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https://www.readbyqxmd.com/read/28806615/graphene-gold-based-nanocomposites-applications-in-cancer-diseases-efficient-detection-and-therapeutic-tools
#1
REVIEW
Lina A Al-Ani, Mohammed A AlSaadi, Farkaad A Kadir, Najihah M Hashim, Nurhidayatullaili M Julkapli, Wageeh A Yehye
Early detection and efficient treatment of cancer disease remains a drastic challenge in 21st century. Throughout the bulk of funds, studies, and current therapeutics, cancer seems to aggressively advance with drug resistance strains and recurrence rates. Nevertheless, nanotechnologies have indeed given hope to be the next generation for oncology applications. According to US National cancer institute, it is anticipated to revolutionize the perspectives of cancer diagnosis and therapy. With such success, nano-hybrid strategy creates a marvelous preference...
July 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28800462/imaging-biodistribution-and-in-vitro-study-of-smart-99m-tc-pamam-g4-dendrimer-as-novel-nano-complex
#2
Asghar Narmani, Kamal Yavari, Javad Mohammadnejad
Overexpression of folic acid receptor in various human tumors cells makes it as good candidate for targeting delivery of chemotherapeutic and radiopharmaceutical agents. In this research, FA used for functionalization of PEG modified PAMAM G4 dendrimer as a smart delivery of 5-FU and (99m)Tc for the breast carcinoma in order to chemotherapeutic and imaging goals. One aim of this research was assess the FA-mediated cell viability assay of PEG-PAMAM G4-FA-5FU-(99m)Tc and in vitro uptake of PEG-PAMAM G4-FA-(99m)Tc as the novel nano-complex determined on C2Cl2 (normal cell) and MCF-7 (breast cancer cell) cell lines...
August 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28792728/an-environment-activatable-nanoprodrug-two-step-surveillance-in-the-anticancer-drug-release
#3
Sandipan Biswas, Joyjyoti Das, Shrabani Barman, Bhaskara Rao Pinninti, Tapas K Maiti, N D Pradeep Singh
Remedial cancer therapy deals with a large number of theranostic applications. However, systems, so far known, are only capable of single surveillance for both diagnostic and therapeutic modes of actions. A nanosystem, which can be localized to the cancer and deliver the chemotherapeutic agent on demand, will provide effective therapeutic activity. Herein, we designed a single component nanoprodrug ANPD-X (Activatable Nano Pro-Drug-X) which indentified the tumor sites by fluorescent colour change (signal 1, blue to green fluorescence) using H2O2-mediated oxidation of boronate fluorophore...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28792261/ph-sensitive-phlip-%C3%A2-coated-niosomes
#4
Mohan C Pereira, Monica Pianella, Da Wei, Anna Moshnikova, Carlotta Marianecci, Maria Carafa, Oleg A Andreev, Yana K Reshetnyak
Nanomedicine is becoming very popular over conventional methods due to the ability to tune physico-chemical properties of nano vectors, which are used for encapsulation of therapeutic and diagnostic agents. However, the success of nanomedicine primarily relies on how specifically and efficiently nanocarriers can target pathological sites to minimize undesirable side effects and enhance therapeutic efficacy. Here, we introduce a novel class of targeted nano drug delivery system, which can be used as an effective nano-theranostic for cancer...
August 9, 2017: Molecular Membrane Biology
https://www.readbyqxmd.com/read/28791767/the-delivery-of-doxorubicin-of-multifunctional-%C3%AE-cyclodextrin-modified-cdse-zns-quantum-dots-for-bioactivity-and-nano-probing
#5
Mei-Xia Zhao, Bing-Jie Zhu, Wen-Jing Yao, Di-Feng Chen, Chaojie Wang
The modified quantum dots (QDs), have been used in intracellular probing and drug delivery because of their special chemical and physical properties. In this paper, two β-cyclodextrin (β-CD)-modified CdSe/ZnS QDs with strong optical emission properties were synthesized as drug carriers to induce apoptosis. The positively charged L-Arginine (L-Arg) and neutral L-Tryptophan (L-Trp) were selected as ligands to compare the effect of charge on bioactivity of QDs nanoparticles. The in vitro assays revealed that these modified QDs showed good Dox carrier ability and significantly high inhibition rate to cancer cells...
August 9, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28790504/cigarette-smoke-and-dna-cleavage-promote-lung-inflammation-and-emphysema
#6
Farrah Kheradmand, R You, Bon Hee Gu, D B Corry
Smoking-related lung diseases are among the most preventable and incurable ailments in the world. Smokers are at increased risk of developing chronic obstructive pulmonary disease that can be further complicated by emphysema and lung cancer. A subset of former smokers shows persistent lung inflammation and progressive loss of lung function, indicating a role for activation of acquired immunity in smoking-induced lung diseases. In addition to the well-established noxious effects of volatile compounds in cigarette smoke, incomplete combustion of tobacco generates nano-sized carbon black (nCB) that accumulate in lung myeloid dendritic cells and macrophages...
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28789523/efficient-sirna-delivery-by-lipid-nanoparticles-modified-with-a-non-standard-macrocyclic-peptide-for-epcam-targeting
#7
Yu Sakurai, Wataru Mizumura, Manami Murata, Tomoya Hada, Shoshiro Yamamoto, Kenichiro Ito, Kazuhiro Iwasaki, Takayuki Katoh, Yuki Goto, Asako Takagi, Michinori Kohara, Hiroaki Suga, Hideyoshi Harashima
The development of a specific, effective method for the delivery of therapeutics including small molecules and nucleic acids to tumor tissue remains to be solved. Numerous types of lipid nanoparticles (LNPs) have been developed in attempts to achieve this goal. However, LNPs are probably not taken up by target cells because cancer-targeting LNPs are typically modified with poly(ethylene glycol) (PEG), which inhibit the cellular uptake of LNPs, to passively accumulate in tumor tissue via the enhanced permeability and retention (EPR) effect...
August 8, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28783505/surface-modification-of-docetaxel-nanocrystals-with-her2-antibody-to-enhance-cell-growth-inhibition-in-breast-cancer-cells
#8
Jin-Seok Choi, Jeong-Sook Park
Here, we describe docetaxel nanocrystals (DTX-NCs) surface-modified with Herceptin(®) (HCT) for combination cancer therapy. Using nano-precipitation and adsorption method, DTX-NCs and HCT-DTX-NCs were successfully prepared. The morphologies of DTX-NCs and HCT-DTX-NCs were characterized by field emission scanning electron microscopy (FE-SEM). The particle size and surface charge were evaluated by zeta-sizer and zeta-potential, respectively. Moreover, DTX-NCs and HCT-DTX-NCs were evaluated in terms of an in vitro drug release, cellular uptake and cytotoxicity...
July 27, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28779891/silver-nanoparticles-in-dentistry
#9
REVIEW
Victor T Noronha, Amauri J Paula, Gabriela Durán, Andre Galembeck, Karina Cogo-Müller, Michelle Franz-Montan, Nelson Durán
OBJECTIVE: Silver nanoparticles (AgNPs) have been extensively studied for their antimicrobial properties, which provide an extensive applicability in dentistry. Because of this increasing interest in AgNPs, the objective of this paper was to review their use in nanocomposites; implant coatings; pre-formulation with antimicrobial activity against cariogenic pathogens, periodontal biofilm, fungal pathogens and endodontic bacteria; and other applications such as treatment of oral cancer and local anesthesia...
August 2, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28774811/the-interaction-of-dendrimer-doxorubicin-conjugates-with-a-model-pulmonary-epithelium-and-their-cosolvent-free-pseudo-solution-formulations-in-pressurized-metered-dose-inhalers
#10
Qian Zhong, Bruno V Humia, Alisha R Punjabi, Francine F Padilha, Sandro R P da Rocha
Oral inhalation (OI) of nano-chemotherapeutics holds great potentials in the treatment of lung cancers as it enables direct targeting of drugs to lung tissues, spatial and temporal control of drug release, and decrease in drug-associated systemic and local lung toxicity. Therefore, the design of chemistry of the nanocarriers and their OI formulations for chemotherapeutics delivery to the peripheral lungs and extrapulmonary tissues of relevance such as lymph nodes, may thus afford new opportunities for treating such relevant diseases...
July 31, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28772434/supercritical-co%C3%A2-assisted-spray-drying-of-strawberry-like-gold-coated-magnetite-nanocomposites-in-chitosan-powders-for-inhalation
#11
Marta C Silva, Ana Sofia Silva, Javier Fernandez-Lodeiro, Teresa Casimiro, Carlos Lodeiro, Ana Aguiar-Ricardo
Lung cancer is one of the leading causes of death worldwide. Therefore, it is of extreme importance to develop new systems that can deliver anticancer drugs into the site of action when initiating a treatment. Recently, the use of nanotechnology and particle engineering has enabled the development of new drug delivery platforms for pulmonary delivery. In this work, POXylated strawberry-like gold-coated magnetite nanocomposites and ibuprofen (IBP) were encapsulated into a chitosan matrix using Supercritical Assisted Spray Drying (SASD)...
January 18, 2017: Materials
https://www.readbyqxmd.com/read/28762267/charge-reversible-multifunctional-hpma-copolymers-for-mitochondrial-targeting
#12
Fengling Wang, Wei Sun, Lian Li, Lijia Li, Yuanyuan Liu, Zhi-Rong Zhang, Yuan Huang
Mitochondrial-oriented delivery of anticancer drugs has been considered as a promising strategy to improve the antitumor efficiency of chemotherapeutics. However, the physiological and biological barriers from the injection site to the final mitochondrial action site remain great challenges. Herein, a novel mitochondrial-targeted multifunctional nanocomplex based on N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers (MPC) is designed to enhance drug accumulation in mitochondria. MPC possesses various functions such as extracellular pH response, superior cellular uptake, lysosomal escape, and mitochondrial targeting...
August 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28758589/carbon-nanotubes-in-the-treatment-of-skin-cancers-safety-and-toxicological-aspects
#13
Nida Akhtar, Kamla Pathak
BACKGROUND: Skin cancer is depicted to be the most common malignant disease across the globe that is frequently diagnosed in people bearing light skin. Three common forms of skin cancers are squamous cell carcinoma, basal cell carcinoma, and malignant melanoma. Treatment of skin cancers comprises of various forms of management strategies that can help in curing the disease including the use of several therapeutic agents. Though numerous therapies have been explored till date to deliver the active therapeutics, nanoparticulate based targeted therapy has garnered considerable interest and is a promising approach in treating skin cancers...
2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28755992/microgels-of-silylated-hpmc-as-a-multimodal-system-for-drug-co-encapsulation
#14
Mohamed Zayed, Corine Tourne-Peteilh, Michel Ramonda, Gildas Rethore, Pierre Weiss, Jean Martinez, Gilles Subra, Ahmad Mehdi, Jean-Marie Devoisselle, Philippe Legrand
Combined therapy is a global strategy developed to prevent drug resistance in cancer and infectious diseases. In this field, there is a need of multifunctional drug delivery systems able to co-encapsulate small drug molecules, peptides, proteins, associated to targeting functions, nanoparticles. Silylated hydrogels are alkoxysilane hybrid polymers that can be engaged in a sol-gel process, providing chemical cross linking in physiological conditions, and functionalized biocompatible hybrid materials. In the present work, microgels were prepared with silylated (hydroxypropyl)methyl cellulose (Si-HPMC) that was chemically cross linked in soft conditions of pH and temperature...
July 26, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28754120/nano-based-delivery-of-rnai-in-cancer-therapy
#15
REVIEW
Yong Xin, Min Huang, Wen Wen Guo, Qian Huang, Long Zhen Zhang, Guan Jiang
BACKGROUND: RNA interference (RNAi), a newly developed method in which RNA molecules inhibit gene expression, has recently received considerable research attention. In the development of RNAi-based therapies, nanoparticles, which have distinctive size effects along with facile modification strategies and are capable of mediating effective RNAi with targeting potential, are attracting extensive interest. OBJECTIVE: This review presents an overview of the mechanisms of RNAi molecules in gene therapy and the different nanoparticles used to deliver RNAi molecules; briefly describes the current uses of RNAi in cancer therapy along with the nano-based delivery of RNA molecules in previous studies; and highlights some other carriers that have been applied in clinical settings...
July 28, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28752708/-advances-in-nanoparticle-targeting-tumor-associated-macrophages-for-cancer-imaging-and-therapy
#16
Guo Fengliang, Tang Guping, H U Qinglian
Tumor tissues are composed of tumor cells and complicate microenvironment. Tumor associated macrophages (TAMs) as an important component in tumor microenvironment, play fundamental roles in tumor progression, metastasis and microenvironment regulation. Recently, studies have found that nanotechnology, as an emerging platform, provides unique potential for cancer imaging and therapy. With the nanotechnology, TAMs imaging presents direct evidence for cancer development, progression, and the effectiveness of cancer treatments; it also can regulate the immunosuppression of tumor microenvironment and improve therapeutic efficiency through TAMs targeted killing or phenotypic transformation...
March 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/28749624/synthesis-characterization-and-evaluation-of-cytotoxic-effects-of-novel-hybrid-steroidal-heterocycles-as-peg-based-nanoparticles
#17
Mervat M Abd Elhalim, Nasser S M Ismail, Shaymaa M M Yahya, Yasmin Y Omar, Ahmed A Abd Rabou, Deena S Lasheen, Mahmoud F Zawrah, Gamal A Elmegeed
Anticancer agents featuring hybrid molecules can improve effectiveness and diminish drug resistance. The current study aimed to introduce newly synthesized heterocyclic steroids of promising anticancer effects loaded in polyethylene glycol (PEG)•based nanoparticles form. Several heterocyclic steroids (1-9) were synthesized via multicomponent reactions (MCRs) and confirmed via the analytical and spectral data. Compounds 1, 2, 3, 4, 5, 6, 7 and 9, were investigated individually in their free and PEG based nano-size hybrid forms as anticancer agents against three human cell lines: hepatocellular carcinoma cells (HepG2); breast cancer cells (MCF-7); and colon cancer cells (HCT116)...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28745644/profiling-anti-neu5gc-igg-in-human-sera-with-a-sialoglycan-microarray-assay
#18
Shani Leviatan Ben-Arye, Hai Yu, Xi Chen, Vered Padler-Karavani
Cells are covered with a cloak of carbohydrate chains (glycans) that is commonly altered in cancer and that includes variations in sialic acid (Sia) expression. These are acidic sugars that have a 9-carbon backbone and that cap vertebrate glycans on cell surfaces. Two of the major Sia forms in mammals are N-acetylneuraminic acid (Neu5Ac) and its hydroxylated form, N-glycolylneuraminic acid (Neu5Gc). Humans cannot produce endogenous Neu5Gc due to the inactivation of the gene encoding cytidine 5'monophosphate-Neu5Ac (CMP-Neu5Ac) hydroxylase (CMAH)...
July 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28743942/covalent-non-covalent-encapsulated-nanodrug-regulate-the-fate-of-intra-and-extracellular-trafficking-impact-on-cancer-and-normal-cells
#19
Sang-Woo Kim, Yeon Kyung Lee, Sang-Hyun Kim, Jun-Young Park, Dong Un Lee, Jungil Choi, Jeong Hee Hong, Sanghyo Kim, Dongwoo Khang
Drugs need to be designed to access the designated intracellular organelle compartments in order to maximize anticancer efficacy. This study identified that covalently conjugated, non-covalent polyethylene glycol coated and encapsulated nanodrugs selectively influence drug uptake, the intracellular and extracellular trafficking of cancer cells. The types of nano conjugation modulated intracellular dynamics associated with differential impact on anti-cancer efficacy, but also induced differential cytotoxicity on cancer versus normal cells...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28742327/amphiphilic-peptide-nanorods-based-on-oligo-phenylalanine-as-a-biocompatible-drug-carrier
#20
Su Jeong Song, Seulgi Lee, Kyoung-Seok Ryu, Joon Sig Choi
Peptide nanostructure has been widely explored for drug-delivery systems in recent studies. Peptides possess comparatively lower cytotoxicity and are more efficient than polymeric carriers. Here, we propose a peptide nanorod system, composed of an amphiphilic oligo-peptide RH3F8 (Arg-His3-Phe8), as a drug-delivery carrier. Arginine is an essential amino acid in typical cell-penetration peptides, and histidine induces endo- and lysosomal escape because of its proton sponge effect. Phenylalanine is introduced to provide rich hydrophobicity for stable self-assembly and drug encapsulation...
August 11, 2017: Bioconjugate Chemistry
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