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https://www.readbyqxmd.com/read/28079217/cisplatin-induced-self-assembly-of-graphene-oxide-sheets-into-spherical-nanoparticles-for-damaging-sub-cellular-dna
#1
Aditi Nandi, Abhik Mallick, Piyush More, Poulomi Sengupta, Nirmalya Ballav, Sudipta Basu
This report describes the hitherto unobserved cisplatin induced self-assembly of 2D-graphene oxide sheets into 3D-spherical nano-scale particles. These nanoparticles can encompass dual DNA damaging drugs simultaneously. A combination of confocal microscopy, gel electrophoresis and flow cytometry studies clearly demonstrated that these novel nanoparticles can internalize into cancer cells by endocytosis, localize into lysosomes, and damage DNA, leading to apoptosis. Cell viability assays indicated that these nanoparticles were more cytotoxic towards cancer cells compared to healthy cells...
January 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28077264/self-assembly-of-green-tea-catechin-derivatives-in-nanoparticles-for-oral-lycopene-delivery
#2
Weikun Li, Murat Yalcin, Qishan Lin, Mohammed-Salleh M Ardawi, Shaker A Mousa
Lycopene is a natural anti-oxidant that has attracted much attention due to its varied applications such as protection against loss of bone mass, chronic diseases, skin cancer, prostate cancer, and cardiovascular disease. However, high instability and extremely low oral bioavailability limits its further clinical development. We selected a green tea catechin derivative, oligomerized (-)-epigallocatechin-3-O-gallate (OEGCG) as a carrier for oral lycopene delivery. Lycopene-loaded OEGCG nanoparticles (NPs) were prepared by a nano-precipitation method, followed by coating with chitosan to form a shell...
January 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28075466/co-delivery-of-doxorubicin-and-ph-sensitive-curcumin-prodrug-by-transferrin-targeted-nanoparticles-for-breast-cancer-treatment
#3
Tongxing Cui, Sihao Zhang, Hong Sun
The natural product curcumin and the chemotherapeutic agent doxorubicin have been used in the treatment of many cancers, including breast cancer. However, fast clearance and unspecific distribution in the body after intravenous injection are still challenges to be overcome by an ideal nano-sized drug delivery system in cancer treatment. In this study we design transferrin (Tf) decorated nanoparticles (NPs) to co-deliver CUR and DOX for breast cancer treatment. A pH-sensitive prodrug, transferrin-poly(ethylene glycol)-curcumin (Tf-PEG-CUR), was synthesized and used for the self‑assembling of NPs (Tf-PEG-CUR NPs)...
January 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28070974/stimulus-responsive-short-peptide-nanogels-for-controlled-intracellular-drug-release-and-overcome-tumor-resistance
#4
Bengang Xing, Linna Lyu, Fang Liu, Xiaoyong Wang, Ming Hu, Jing Mu, Haolun Cheong, Gang Liu
Multidrug resistance (MDR) places a major burden against cancer treatment. As one important factor contributing to MDR, over-expression of P-glycoprotein (P-gp), results in the reduced intracellular drug accumulation. Hence, the ability to effectively block the efflux protein and accumulate the therapeutics in cancer cells is of great significance in clinical practice. In this work, we successfully developed a smart stimulus-responsive short peptide assembled system, termed as PD/VER nanogels, which synergistically combined the acid activatable Doxorubicin (Dox) antitumor prodrug with the P-gp inhibitor (Verapamil, VER) for reversing MDR...
January 9, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28069192/acoustic-cavitation-induced-generation-of-stabilizer-free-extremely-stable-reduced-graphene-oxide-nanodispersion-for-efficient-delivery-of-paclitaxel-in-cancer-cells
#5
Renu Geetha Bai, Kasturi Muthoosamy, Fiona Natalia Shipton, Sivakumar Manickam
Graphene is one of the highly explored nanomaterials due to its unique and extraordinary properties. In this study, by utilizing a hydrothermal reduction method, graphene oxide (GO) was successfully converted to reduced graphene oxide (RGO) without using any toxic reducing agents. Following this, with the use of ultrasonic cavitation, profoundly stable few layer thick RGO nanodispersion was generated without employing any stabilizers or surfactants. During ultrasonication, shockwaves from the collapse of bubbles cause a higher dispersing energy to the graphene nanosheets which surpass the forces of Van der Waal's and π-π stacking and thus pave the way to form a stable aqueous nanodispersion of graphene...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28068637/assembling-of-multifunctional-latex-based-hybrid-nanocarriers-from-calotropis-gigantea-for-sustained-doxorubicin-dox-releases
#6
Periyakaruppan Pradeepkumar, Dharman Govindaraj, Murugaraj Jeyaraj, Murugan A Munusamy, Mariappan Rajan
Natural rubber Latex (Lax) is a colloidal dispersion of polymer particles in liquid and shows good biodegradable, biocompatibility, and non-toxicity. Natural polymers are the most important materials used in food packaging, micro/nano-drug delivery, tissue engineering, agriculture, and coating. In the present study, natural compounds extracted from plant Lax were designed to function as drug carriers using various surfactants via emulation and solvent evaporation method. Calotropis gigantea belongs to the family Apocynaceae and has received considerable attention in modern medicine, ayurvedeic, siddha, and traditional medicine...
January 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28068099/mechanisms-and-barriers-in-cancer-nanomedicine-addressing-challenges-looking-for-solutions
#7
Thomas J Anchordoquy, Yechezkel Barenholz, Diana Boraschi, Michael Chorny, Paolo Decuzzi, Marina A Dobrovolskaia, Z Shadi Farhangrazi, Dorothy Farrell, Alberto Gabizon, Hamidreza Ghandehari, Biana Godin, Ninh M La-Beck, Julia Ljubimova, S Moein Moghimi, Len Pagliaro, Ji-Ho Park, Dan Peer, Erkki Ruoslahti, Natalie J Serkova, Dmitri Simberg
Remarkable progress has recently been made in the synthesis and characterization of engineered nanoparticles for imaging and treatment of cancers, resulting in several promising candidates in clinical trials. Despite these advances, clinical applications of nanoparticle-based therapeutic/imaging agents remain limited by biological, immunological, and translational barriers. In order to overcome the existing status quo in drug delivery, there is a need for open and frank discussion in the nanomedicine community on what is needed to make qualitative leaps toward translation...
January 9, 2017: ACS Nano
https://www.readbyqxmd.com/read/28060268/a-facile-and-efficient-approach-for-the-production-of-reversible-disulfide-cross-linked-micelles
#8
Yuanpei Li, Gaurav Bharadwaj, Joyce S Lee
Nanomedicine is an emerging form of therapy that harnesses the unique properties of particles that are nanometers in scale for biomedical application. Improving drug delivery to maximize therapeutic outcomes and to reduce drug-associated side effects are some of the cornerstones of present-day nanomedicine. Nanoparticles in particular have found a wide application in cancer treatment. Nanoparticles that offer a high degree of flexibility in design, application, and production based on the tumor microenvironment are projected to be more effective with rapid translation into clinical practice...
December 23, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28056439/fe3o4-nanoparticles-on-graphene-oxide-sheets-for-isolation-and-ultrasensitive-amperometric-detection-of-cancer-biomarker-proteins
#9
Mohamed Sharafeldin, Gregory W Bishop, Snehasis Bhakta, Abdelhamid El-Sawy, Steven L Suib, James F Rusling
Ultrasensitive mediator-free electrochemical detection for biomarker proteins was achieved at low cost using a novel composite of Fe3O4 nanoparticles loaded onto graphene oxide (GO) nano-sheets (Fe3O4@GO). This paramagnetic Fe3O4@GO composite (1µm size range) was decorated with antibodies against prostate specific antigen (PSA) and prostate specific membrane antigen (PSMA), and then used to first capture these biomarkers and then deliver them to an 8-sensor detection chamber of a microfluidic immunoarray. Screen-printed carbon sensors coated with electrochemically reduced graphene oxide (ERGO) and a second set of antibodies selectively capture the biomarker-laden Fe3O4@GO particles, which subsequently catalyze hydrogen peroxide reduction to detect PSA and PSMA...
December 27, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28056402/engineering-hepatitis-b-virus-core-particles-for-targeting-her2-receptors-in%C3%A2-vitro-and-in%C3%A2-vivo
#10
Izzat Fahimuddin Bin Mohamed Suffian, Julie Tzu-Wen Wang, Naomi O Hodgins, Rebecca Klippstein, Mitla Garcia-Maya, Paul Brown, Yuya Nishimura, Hamed Heidari, Sara Bals, Jane K Sosabowski, Chiaki Ogino, Akihiko Kondo, Khuloud T Al-Jamal
Hepatitis B Virus core (HBc) particles have been studied for their potential as drug delivery vehicles for cancer therapy. HBc particles are hollow nano-particles of 30-34 nm diameter and 7 nm thick envelopes, consisting of 180-240 units of 21 kDa core monomers. They have the capacity to assemble/dis-assemble in a controlled manner allowing encapsulation of various drugs and other biomolecules. Moreover, other functional motifs, i.e. receptors, receptor binding sequences, peptides and proteins can be expressed...
December 14, 2016: Biomaterials
https://www.readbyqxmd.com/read/28053523/anti-muc1-nano-aptamers-for-triple-negative-breast-cancer-imaging-by-single-photon-emission-computed-tomography-in-inducted-animals-initial-considerations
#11
Fagner Santos do Carmo, Eduardo Ricci-Junior, Cristal Cerqueira-Coutinho, Marta de Souza Albernaz, Emerson Soares Bernardes, Sotiris Missailidis, Ralph Santos-Oliveira
The early and specific detection of tumors remains a barrier in oncology, especially in cases such as the triple-negative breast cancer (TNBC). To address this gap, aptamers have found an important application in the recognition of tumor biomarkers such as mucin 1 (MUC1). However, there are still some difficulties in the use of aptamer, as their rapid biological clearance makes their use as drugs limited. In this study, the anti-MUC1 aptamer was used as a drug delivery system (DDS) for a radioactive polymeric nanoparticle (NP) in the imaging of TNBCs...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28052673/-clickable-nanogels-via-thermally-driven-self-assembly-of-polymers-facile-access-to-targeted-imaging-platforms-using-thiol-maleimide-conjugation
#12
Bugra Aktan, Laura Chambre, Rana Sanyal, Amitav Sanyal
Mutlifunctionalizable nanogels are fabricated using thermally driven self-assembly and crosslinking of reactive thermoresponsive copolymers. Nanogels thus fabricated can be easily conjugated with various appropriately functionalized small molecules and/or ligands to tailor them for various applications in delivery and imaging. In this study, poly (ethylene glycol) methacrylate based maleimide bearing copolymer was crosslinked with a dithiol-based crosslinker to synthesize nanogels. Due to lower critical solution temperature around 55 oC in aqueous media, these copolymers assemble into nano-sized aggregates when heated to this temperature, and are crosslinked using the thiol-maleimide conjugation...
January 4, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28048484/we-fg-201-04-cloud-based-collaboration-for-radiotherapy-clinical-trials-research-and-training
#13
J Palta
: Many low- and middle-income countries lack the resources and services to manage cancer, from screening and diagnosis to radiation therapy planning, treatment and quality assurance. The challenges in upgrading or introducing the needed services are enormous, and include severe shortages in equipment and trained staff. In this symposium, we will describe examples of technology and scientific research that have the potential to impact all these areas. These include: (1) the development of high-quality/low-cost colposcopes for cervical cancer screening, (2) the application of automated radiotherapy treatment planning to reduce staffing shortages, (3) the development of a novel radiotherapy treatment unit, and (4) utilizing a cloud-based infrastructure to facilitate collaboration and QA...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048374/we-fg-201-00-high-impact-technologies-for-low-resource-environments
#14
Laurence Edward Court
: Many low- and middle-income countries lack the resources and services to manage cancer, from screening and diagnosis to radiation therapy planning, treatment and quality assurance. The challenges in upgrading or introducing the needed services are enormous, and include severe shortages in equipment and trained staff. In this symposium, we will describe examples of technology and scientific research that have the potential to impact all these areas. These include: (1) the development of high-quality/low-cost colposcopes for cervical cancer screening, (2) the application of automated radiotherapy treatment planning to reduce staffing shortages, (3) the development of a novel radiotherapy treatment unit, and (4) utilizing a cloud-based infrastructure to facilitate collaboration and QA...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047773/we-fg-bra-09-using-graphene-oxide-nano-flakes-during-image-guided-radiotherapy-to-minimize-the-potential-of-cancer-recurrence-or-metastasis
#15
D Toomeh, W Ngwa, E Sajo, Y Hao, S Gadoue
PURPOSE: An increasing number of studies show that cancer stem cells (CSCs) become more invasive (metastatic) and may escape into the blood stream and lymph nodes during radiotherapy (RT), before they have received a lethal dose during RT. Other Studies have shown that Graphene oxide (GO) can selectively inhibit the proliferative expansion of CSCs across multiplicative tumor types. In this study we investigate the feasibility of using GO during radiotherapy (RT) to minimize the escape of CSCs towards preventing cancer metastasis or recurrence...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047729/we-fg-201-01-patient-centric-technologies-for-diagnosis-of-breast-and-cervical-cancer
#16
N Ramanujam
: Many low- and middle-income countries lack the resources and services to manage cancer, from screening and diagnosis to radiation therapy planning, treatment and quality assurance. The challenges in upgrading or introducing the needed services are enormous, and include severe shortages in equipment and trained staff. In this symposium, we will describe examples of technology and scientific research that have the potential to impact all these areas. These include: (1) the development of high-quality/low-cost colposcopes for cervical cancer screening, (2) the application of automated radiotherapy treatment planning to reduce staffing shortages, (3) the development of a novel radiotherapy treatment unit, and (4) utilizing a cloud-based infrastructure to facilitate collaboration and QA...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047079/we-fg-201-02-automated-treatment-planning-for-low-resource-settings
#17
L Court
: Many low- and middle-income countries lack the resources and services to manage cancer, from screening and diagnosis to radiation therapy planning, treatment and quality assurance. The challenges in upgrading or introducing the needed services are enormous, and include severe shortages in equipment and trained staff. In this symposium, we will describe examples of technology and scientific research that have the potential to impact all these areas. These include: (1) the development of high-quality/low-cost colposcopes for cervical cancer screening, (2) the application of automated radiotherapy treatment planning to reduce staffing shortages, (3) the development of a novel radiotherapy treatment unit, and (4) utilizing a cloud-based infrastructure to facilitate collaboration and QA...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047048/su-f-t-662-feasibility-study-of-fe3o4-taox-nano-particles-as-a-radiosensitizer-for-radiation-therapy
#18
S Ahn, N Lee, S Shin, C Choi, Y Han, H Park, D Choi, D Lim
PURPOSE: To investigate the feasibility of using multifunctional Fe3 O4 /TaOx(core / shell) nano particles developed for CT and MRI contrast agent as dose enhancing radiosensitizers. METHODS: Firstly, to verify the imaging detectability of Fe3 O4 /TaOx nano particles, in-vivo tests were conducted. Approximately 600 mg/kg of 19 nm diameter Fe3 O4 /TaOx nano particles dispersed in phosphate buffered saline(PBS) were injected to ten nude Balb/c mice through the tail vein...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046999/su-f-sps-08-measuring-the-interaction-of-ddr-cell-receptors-and-extracellular-matrix-collagen-in-prostate-cells
#19
J Dong, A Sarkar, A Suhail, R Fridman, P Hoffmann
PURPOSE: Discoidin domain receptors (DDR) have recently been recognized as important players in cancer progression. DDRs are cell receptors that interact with collagen, an extracellular matrix (ECM) protein. However the detailed mechanism of their interaction is unclear. Here we attempted to examine their interaction in terms of structural (surface topography), mechanical (rupture force), and kinetic (binding probability) information on the single molecular scale with the use of atomic force microscopy (AFM)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046418/we-fg-201-03-lean-innovation-transforming-global-access-to-best-practice-radiotherapy-treatment
#20
I Feain
: Many low- and middle-income countries lack the resources and services to manage cancer, from screening and diagnosis to radiation therapy planning, treatment and quality assurance. The challenges in upgrading or introducing the needed services are enormous, and include severe shortages in equipment and trained staff. In this symposium, we will describe examples of technology and scientific research that have the potential to impact all these areas. These include: (1) the development of high-quality/low-cost colposcopes for cervical cancer screening, (2) the application of automated radiotherapy treatment planning to reduce staffing shortages, (3) the development of a novel radiotherapy treatment unit, and (4) utilizing a cloud-based infrastructure to facilitate collaboration and QA...
June 2016: Medical Physics
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