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linezolid resistance

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https://www.readbyqxmd.com/read/28922806/linezolid-as-treatment-for-pulmonary-mycobacterium-avium-disease
#1
Devyani Deshpande, Shashikant Srivastava, Jotam G Pasipanodya, Tawanda Gumbo
Objectives: To identify the pharmacokinetic/pharmacodynamic parameters and exposures of linezolid in the treatment of pulmonary Mycobacterium avium complex (MAC) disease. Methods: Human-derived monocytes infected with MAC were inoculated into hollow-fibre systems for dose-effect and dose-scheduling studies. We mimicked linezolid concentration-time profiles achieved in adult human lungs treated for 28 days. Sampling to confirm that the intended linezolid pharmacokinetics had been achieved, and for enumeration of MAC colony-forming units, was performed based on repetitive sampling from each system over the 28 days...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28919606/current-trends-of-using-antimicrobials-and-their-sensitivity-pattern-in-infectious-cases-at-department-of-orthopedics-in-a-tertiary-care-hospital
#2
M M Sarker, S K Saha, S Saha, A N Naushad, S Ajmery, P Roy, M S Chowdhury, L Mukta
This cross-sectional descriptive study was carried out to analyse the current trends of using antimicrobials at orthopaedics department in different surgical procedures and observe the antimicrobial sensitivity pattern of infective organisms in postoperative wound infection cases at the department of Orthopaedics, Mymensingh Medical College Hospital with collaboration of department of Pharmacology and Therapeutics in Mymensingh Medical College, Mymensingh from January 2016 to December 2016. Among 253 orthopaedics surgical cases Penicillins, Cephalosporins, and Aminoglycoside group were commonly prescribed antimicrobials that had been use postoperatively in most of the Orthopaedics cases...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28899468/-pathogen-distribution-and-bacterial-resistance-in-children-with-severe-community-acquired-pneumonia
#3
Yun-Yun Lu, Rong Luo, Zhou Fu
OBJECTIVE: To investigate the distribution of pathogens and bacterial resistance in children with severe community-acquired pneumonia (CAP). METHODS: A total of 522 children with severe CAP who were hospitalized in 2016 were enrolled as study subjects. According to their age, they were divided into infant group (402 infants aged 28 days to 1 year), young children group (73 children aged 1 to 3 years), preschool children group (35 children aged 3 to 6 years), and school-aged children group (12 children aged ≥6 years)...
September 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28894692/case-report-infection-of-total-knee-arthroplasty-treated-with-one-stage-surgery-and-linezolid
#4
Adriana Macedo Dell'Aquila, Cesar Janovsky, Moises Cohen
Staphylococcus spp meticillin resistant infection can be treated with Linezolid. This is a case report of an orthopaedic implant infection in a 60 year-old male treated orally with Linezolid and Rifampicin for three months after one-stage arthroplasty. This is possible provided that platelet count is closely monitored throughout the course of treatment.
2017: Journal of bone and joint infection
https://www.readbyqxmd.com/read/28889756/occurrence-of-vancomycin-resistant-staphylococcus-aureus-in-the-oral-cavity-of-patients-with-dental-caries
#5
Sajith Vellappally, Darshan Devang Divakar, Abdulaziz Abdullah Al Kheraif, Ravikumar Ramakrishnaiah, Amer Alqahtani, M H N Dalati, Sukumaran Anil, Aftab Ahmed Khan, P R Harikrishna Varma
Oral streptococci are the major group of microbes isolated from oral microflora. They represent frequent pathogens of infective endocarditis (IE), and it is assumed that in most of the cases oral streptococci are acquired via mucosa layer of oral cavity. Staphylococcus aureus is also frequently isolated from IE as it accounts for 20%-30% of all cases. Vancomycin has been the most reliable therapeutic agent against infections caused by methicillin-resistant S. aureus (MRSA). The main objective of this study was to examine the occurrence of S...
September 11, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28882763/antimicrobial-resistance-of-enterococcus-in-turkey-a-meta-analysis-of-current-studies
#6
Imdat Kilbas, Ihsan Hakki Ciftci
OBJECTIVES: This study conducted a meta-analysis of Enterococcus isolates collected in 2000-2015 in Turkey and their susceptibility and resistance to antibiotics, clinical indications for the initial drug treatment, and identification of alternative treatments. METHODS: This meta-analysis examined antibiotic susceptibility and resistance in Enterococcus. The study was planned and conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses...
September 4, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28882325/antimicrobial-stewardship-programme-in-critical-care-medicine-a-prospective-interventional-study
#7
J Ruiz, P Ramirez, M Gordon, E Villarreal, J Frasquet, J L Poveda-Andres, M Salavert-Lletí, A Catellanos
OBJECTIVE: Hospital antimicrobial stewardship programmes have achieved savings and a more rational use of antimicrobial treatments in general wards. The purpose of this report is to evaluate the experience of an antimicrobial stewardship programme in an intensive care unit (ICU). DESIGN: Prospective interventional, before-and-after study. SCOPE: 24-bed medical ICU in a tertiary hospital. INTERVENTION: Prospective audit and feedback antimicrobial stewardship programme...
September 4, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/28880552/novel-inhibitors-of-staphyloxanthin-virulence-factor-in-comparison-with-linezolid-and-vancomycin-versus-methicillin-resistant-linezolid-resistant-and-vancomycin-intermediate-staphylococcus-aureus-infections-in-vivo
#8
Shuaishuai Ni, Hanwen Wei, Baoli Li, Feifei Chen, Yifu Liu, Wenhua Chen, Yixiang Xu, Xiaoxia Qiu, Xiaokang Li, Yanli Lu, Wenwen Liu, Linhao Hu, Dazheng Lin, Manjiong Wang, Xinyu Zheng, Fei Mao, Jin Zhu, Le-Fu Lan, Jian Li
Our previous work (Wang, et al. J. Med. Chem. 2016, 59, 4831-4848) revealed that effective benzocycloalkane-derived staphyloxanthin inhibitors against methicillin-resistant Staphylococcus aureus (S. aureus) infections were accompanied by poor water solubility and high hERG inhibition and dosages (pre-administration). In this study, ninety-two chroman and coumaran derivatives as novel inhibitors have been addressed for overcoming deficiencies above. Derivatives 69 and 105 displayed the excellent pigment inhibitory activities and low hERG inhibition, along with the improvement of solubility by salt type selection...
September 7, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28874470/inhibition-of-the-atp-synthase-eliminates-the-intrinsic-resistance-of-staphylococcus-aureus-towards-polymyxins
#9
Martin Vestergaard, Katrine Nøhr-Meldgaard, Martin Saxtorph Bojer, Christina Krogsgård Nielsen, Rikke Louise Meyer, Christoph Slavetinsky, Andreas Peschel, Hanne Ingmer
Staphylococcus aureus is intrinsically resistant to polymyxins (polymyxin B and colistin), an important class of cationic antimicrobial peptides used in treatment of Gram-negative bacterial infections. To understand the mechanisms underlying intrinsic polymyxin resistance in S. aureus, we screened the Nebraska Transposon Mutant Library established in S. aureus strain JE2 for increased susceptibility to polymyxin B. Nineteen mutants displayed at least 2-fold reductions in MIC, while the greatest reductions (8-fold) were observed for mutants with inactivation of either graS, graR, vraF, or vraG or the subunits of the ATP synthase (atpA, atpB, atpG, or atpH), which during respiration is the main source of energy...
September 5, 2017: MBio
https://www.readbyqxmd.com/read/28872282/changes-in-bacterial-flora-and-antibiotic-resistance-in-clinical-samples-isolated-from-patients-hospitalized-in-the-military-institute-of-medicine-in-warsaw-poland-between-2005-2012
#10
Aneta Guzek, Zbigniew Rybicki, Dariusz Tomaszewski
BACKGROUND: Hospital infections have become an important problem. Knowledge of microbiological situations both helps in ensuring that the optimal choice of antibacterial treatment is made, and in improving the results of the selected therapy. OBJECTIVE: In this paper, both the changes in the bacterial flora of patients hospitalized in the Military Institute of Medicine, and the bacterial resistance to antimicrobials were analyzed. MATERIAL AND METHODS: Data were collected between 2005 and 2012...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/28870771/identification-and-antimicrobial-susceptibility-of-clinical-nocardia-species-in-a-tertiary-hospital
#11
Ming Wei, Peng Wang, Jiuxin Qu, Ran Li, Yongzhe Liu, Li Gu, Chunxia Yang
OBJECTIVES: The aim of this study was to determine the antibiotic susceptibility of 28 clinical isolates of Nocardia species isolated from Beijing Chao-Yang Hospital, for reducing the insufficiency of information on antimicrobial activities of Nocardia clinical isolates in specific species in China. METHODS: Molecular diagnosis of Nocardia species was performed using partial 16S rRNA and rpoB gene sequences. Antimicrobial susceptibility testing by broth microdilution was performed according to the Clinical and Laboratory Standards Institute recommendations...
September 1, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28866136/major-globally-disseminated-clonal-complexes-of-antimicrobial-resistant-enterococci-associated-with-infections-in-cancer-patients-in-brazil
#12
Barbara A Santos, Jéssica S Oliveira, Nayara T Cardoso, André V Barbosa, Silvana V Superti, Lúcia M Teixeira, Felipe P G Neves
Cancer and hematological malignancies constitute major comorbidities in enterococcal infections, but little is known about the characteristics of enterococci affecting cancer patients. The aim of this study was to characterize 132 enterococcal clinical isolates obtained from cancer patients attending a Cancer Reference Center in Brazil between April 2013 and March 2014. Susceptibility to 17 antimicrobial agents was assessed by disk diffusion method. Resistance and virulence genes were investigated by PCR. Multilocus sequence typing (MLST) was performed for selected Enterococcus faecalis and Enterococcus faecium isolates...
September 1, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28857738/detection-of-high-levels-of-resistance-to-linezolid-and-vancomycin-in-staphylococcus-aureus
#13
Aysha Azhar, Samreen Rasool, Asma Haque, Sidra Shan, Muhammad Saeed, Beenish Ehsan, Abdul Haque
Both methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) are rapidly overcoming the current array of drugs. One hundred and fifty isolates from a hospital were studied for resistance towards linezolid and vancomycin. Fifty-four (36.0 %) isolates were MRSA. Both MRSA and MSSA showed high resistance towards linezolid when using the disc diffusion method, with the figures being 48.1 and 29.2 %, respectively. The figures for the E-test were 46.3 and 27.0 %, respectively...
September 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28837596/membrane-active-macromolecules-kill-antibiotic-tolerant-bacteria-and-potentiate-antibiotics-towards-gram-negative-bacteria
#14
Divakara S S M Uppu, Mohini M Konai, Paramita Sarkar, Sandip Samaddar, Isabel C M Fensterseifer, Celio Farias-Junior, Paramanandam Krishnamoorthy, Bibek R Shome, Octávio L Franco, Jayanta Haldar
Chronic bacterial biofilms place a massive burden on healthcare due to the presence of antibiotic-tolerant dormant bacteria. Some of the conventional antibiotics such as erythromycin, vancomycin, linezolid, rifampicin etc. are inherently ineffective against Gram-negative bacteria, particularly in their biofilms. Here, we report membrane-active macromolecules that kill slow dividing stationary-phase and antibiotic tolerant cells of Gram-negative bacteria. More importantly, these molecules potentiate antibiotics (erythromycin and rifampicin) to biofilms of Gram-negative bacteria...
2017: PloS One
https://www.readbyqxmd.com/read/28830510/prevalence-of-methicillin-resistant-staphylococcus-aureus-carriage-on-admission-among-patients-attending-regional-hospitals-in-dar-es-salaam-tanzania
#15
Agricola Joachim, Sabrina J Moyo, Lillian Nkinda, Mtebe Majigo, Elia Mbaga, Naboth Mbembati, Said Aboud, Eligius F Lyamuya
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen responsible for hospital and community acquired infection. Colonization with MRSA is associated with a high risk of developing infection. This study aimed to determine the rate of MRSA carriage on admission and the associated risk factors among patients attending regional hospitals, in Dar es Salaam, Tanzania. RESULTS: A total of 258 patients were included in this study. Nasal swabs were collected on admission to the hospital and after 48 h of hospital stay for detection of MRSA...
August 22, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28828970/antimicrobial-resistance-patterns-of-the-gram-positive-bacteria-isolated-from-children-with-bloodstream-infection-in-an-iranian-referral-hospital-a-6-year-study
#16
Setareh Mamishi, Babak Pourakbari, Shima Mahmoudi, Mina Moradzadeh, Masoumeh Mahzari, Mohammad TaghiHaghi Ashtiani, Parin Tanzifi
BACKGROUND: Bloodstream infections (BSI) are considered as a serious cause of morbidity and mortality in pediatricschildren. The aim of this study was to depict report the common Gram-positive bacteria (GPB) responsible for bloodstream infections in children and determine their antimicrobial resistance patterns in Children Medical Center Hospital (CMC), ) Hospital, Tehran, Iran. METHODS: This retrospective study was conducted within a six-year period (March 2011 to September 2016) for pediatric patients with BSI...
August 21, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28819600/extensively-drug-resistant-tuberculosis-of-the-lumbar-spine-in-a-six-year-old-child-a-case-report
#17
Siddharth Sanjay Shah, Aakanksha Arvind Goregaonkar, Arvind Balkrishna Goregaonkar
INTRODUCTION: The emergence of extensively drug-resistant tuberculosis (XDR-TB) is a challenging paradigm shift faced by the TB control programs worldwide today. The treatment is further compounded with unique management difficulties faced in pediatric patients. Treatment of XDR-TB requires prolonged chemotherapy with second-line drugs which offer lesser potency and increased risk of drug-related side effects. We present a case of spinal XDR-TB in a child, managed with extended second-line antitubercular chemotherapy (ATT)...
March 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28814382/predictive-utility-of-swab-screening-for-vancomycin-resistant-enterococcus-in-selection-of-empiric-antibiotics-for-enterococcus-sterile-site-infections-a-retrospective-cohort-study
#18
Ian Brasg, Marion Elligsen, Derek MacFadden, Nick Daneman
BACKGROUND: Swab screening for vancomycin-resistant Enterococcus (VRE) is used to identify VRE carriers and thus prevent transmission of this organism. We tested whether screening results could have unintended benefits in predicting the vancomycin susceptibility of subsequent Enterococcus infections experienced by these patients. METHODS: We conducted a retrospective cohort study of all patients admitted to a large tertiary care hospital between 2010 and 2015 who underwent swab screening for VRE before experiencing an Enterococcus sterile-site infection...
August 15, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28813477/colonization-prevalence-and-antibiotic-susceptibility-of-group-b-streptococcus-in-pregnant-women-over-a-6-year-period-in-dongguan-china
#19
Wenjing Ji, Lihua Zhang, Zhusheng Guo, Shujin Xie, Weiqing Yang, Junjian Chen, Jiamin Wang, Zhiqin Cheng, Xin Wang, Xuehai Zhu, Jianwen Wang, Haiqing Wang, Juan Huang, Ning Liang, David J McIver
This study investigated the prevalence of recto-vaginal Group B Streptococcus (GBS) colonization, serotype distribution, and antimicrobial susceptibility patterns among pregnant women in Dongguan, China. Recto-vaginal swabs were collected from pregnant women at gestational age 35-37 weeks between January 1st 2009 and December 31st 2014. Isolates were serotyped by latex-agglutination and were tested against seven antimicrobials by disk diffusion. Of 7,726 pregnant women who completed GBS testing, 636 (8.2%) were GBS carriers...
2017: PloS One
https://www.readbyqxmd.com/read/28810329/-distribution-and-drug-resistance-of-pathogens-at-hematology-department-of-jiangsu-province-from-2014-to-2015-results-from-a-multicenter-retrospective-study
#20
Y K Wan, W Sang, B Chen, Y G Yang, L Q Zhang, A N Sun, Y J Liu, Y Xu, Y P Cai, C B Wang, Y F Shen, Y W Jiang, X Y Zhang, W Xu, M Hong, T Chen, R R Xu, F Li, Y L Xu, Y Xue, Y L Lu, Z M He, W M Dong, Z Chen, M H Ji, Y Y Yang, L J Zhai, Y Zhao, G Q Wu, J H Ding, J Cheng, W B Cai, Y M Sun, J Ouyang
Objective: To describe the distribution and drug resistance of pathogens at hematology department of Jiangsu Province from 2014 to 2015 to provide reference for empirical anti-infection treatment. Methods: Pathogens were from hematology department of 26 tertiary hospitals in Jiangsu Province from 2014 to 2015. Antimicrobial susceptibility testing was carried out according to a unified protocol using Kirby-Bauer method or agar dilution method. Collection of drug susceptibility results and corresponding patient data were analyzed...
July 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
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