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François Jacques, Adrian Schembri, Avi Nativ, Chantal Paquette, Pawel Kalinowski
Background: Both prolonged-release fampridine (PRF) and enabling active motor training (EAMT) are beneficial in multiple sclerosis (MS) patients. Their combined effect is, however, understudied. Objective: The objective of this paper is to determine if PRF augments the beneficial effect of EAMT in MS patients as opposed to placebo. Method: This is a pilot, randomized, placebo-controlled, double-blind 14-week study. Participants were randomly assigned to receive PRF 10 mg BID ( n  = 21) or placebo ( n  = 20)...
January 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
In Yae Cheong, So Yeon An, Won Chul Cha, Mi Yong Rha, Seung Tae Kim, Dong Kyung Chang, Ji Hye Hwang
BACKGROUND: The use of a mobile health care application, the delivery of health care or health care-related services through the use of portable devices, to manage functional loss, treatment-related toxicities, and impaired quality of life in cancer patients during chemotherapy through supervised self-management has been increasing. The aim of the present study was to evaluate the efficacy and feasibility of comprehensive mobile health care using a tailored rehabilitation program for colorectal cancer patients undergoing active chemotherapy...
February 17, 2018: Clinical Colorectal Cancer
Alexandria Boutros, Seung Suk Kang, Nash N Boutros
Around 20-25% of the current offenders in Cook County Jail of Chicago Illinois are mentally ill. Each one of these offenders had to be named competent to stand trial when they were first being tried in court. The majority of these offenders that were considered incompetent to stand trial (IST) had to go through the competency restoration process where they were housed in a state hospital and received treatment until the court could deem them to be competent to stand trial. Many defendants with minor offenses that were eventually deemed competent to stand trial, stood trial and were found guilty and sent to jail...
March 2018: International Journal of Law and Psychiatry
Ganbold Lundeg, Amanda Baric, David C Pescod, Keith Pescod
Anesthesia in Mongolia has undergone a period of major development over the past 17 years, thanks to the work of the Mongolian Society of Anesthesiologists (MSA) and the support of the World Federation of Societies of Anaesthesiologists and the Australian Society of Anaesthetists. The specialty has made major advances in training and in its standing among medical specialties in Mongolia. The MSA has produced members who are leaders in the development of anesthesia as well as emergency medicine and critical care...
April 2018: Anesthesia and Analgesia
Vivek Kumar, Antonio Francis, Pasco B Avery, Cindy L McKenzie, Lance S Osborne
Rugose spiraling whitefly (RSW), Aleurodicus rugioperculatus Martin (Hemiptera: Aleyrodidae) is a new invasive whitefly pest in the Florida landscape, known to feed on a wide range of plants including palms, woody ornamentals, shrubs, and fruits. With the objective to find an alternative to neonicotinoid insecticides, and develop an ecofriendly management program for RSW, in the current study we evaluated the efficacy of a biopesticide containing the entomopathogenic fungi, Isaria fumosorosea Wize (Hypocreales: Clavicipitaceae), and an insect growth regulator buprofezin applied alone and in combination under laboratory and field conditions...
March 13, 2018: Journal of Economic Entomology
Shefaly Shorey, Cornelia Chee, Yap-Seng Chong, Esperanza Debby Ng, Ying Lau, Cindy-Lee Dennis
BACKGROUND: Multiple international agencies, including the World Health Organization and the International Monetary Fund, have emphasized the importance of maternal mental health for optimal child health and development. Adequate social support is vital for the most vulnerable to postpartum mood disorders. Hence, an urgent need for sustainable social support programs to aid mothers ease into their new parenting role exists. OBJECTIVE: This study protocol aims to examine the effectiveness of a technology-based peer support intervention program among mothers at risk for postnatal depression in the early postpartum period...
March 14, 2018: JMIR Research Protocols
Darren A Cusanovich, James P Reddington, David A Garfield, Riza M Daza, Delasa Aghamirzaie, Raquel Marco-Ferreres, Hannah A Pliner, Lena Christiansen, Xiaojie Qiu, Frank J Steemers, Cole Trapnell, Jay Shendure, Eileen E M Furlong
Understanding how gene regulatory networks control the progressive restriction of cell fates is a long-standing challenge. Recent advances in measuring gene expression in single cells are providing new insights into lineage commitment. However, the regulatory events underlying these changes remain unclear. Here we investigate the dynamics of chromatin regulatory landscapes during embryogenesis at single-cell resolution. Using single-cell combinatorial indexing assay for transposase accessible chromatin with sequencing (sci-ATAC-seq), we profiled chromatin accessibility in over 20,000 single nuclei from fixed Drosophila melanogaster embryos spanning three landmark embryonic stages: 2-4 h after egg laying (predominantly stage 5 blastoderm nuclei), when each embryo comprises around 6,000 multipotent cells; 6-8 h after egg laying (predominantly stage 10-11), to capture a midpoint in embryonic development when major lineages in the mesoderm and ectoderm are specified; and 10-12 h after egg laying (predominantly stage 13), when each of the embryo's more than 20,000 cells are undergoing terminal differentiation...
March 14, 2018: Nature
Jeong-Ah Ahn, Sunhee Lee
Mothers of children with congenital heart disease (CHD) tend to be concerned about their child's normal life. The majority of these mothers tend to experience negative psychological problems. In this study, the adaptation process of mothers raising a child with complex CHD was investigated based on the sociocultural context of Korea. The data collection was conducted by in-depth interviews and theoretical sampling was performed until the data were saturated. The collected data were analyzed using continuous theoretical comparisons...
January 1, 2018: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
Andrew J Kossow, Tyler G DeChiara, Steve M Neahous, William P Ebben
Plyometric exercises are frequently performed as part of a strength and conditioning program. Most studies assessed the kinetics of plyometric exercises primarily performed in the vertical plane. The purpose of this study was to evaluate the multi-planar kinetic characteristics of a variety of plyometric exercises, which have a significant horizontal component. This study also sought to assess sex differences in the intensity progression of these exercises. Ten men and ten women served as subjects. The subjects performed a variety of plyometric exercises including the double leg hop, standing long jump, single leg standing long jump, bounding, skipping, power skipping, cone hops, and 45...
March 12, 2018: Journal of Strength and Conditioning Research
Megan Knox, Aimee Stewart, Carol L Richards
OBJECTIVE: To evaluate a minimal dose intervention of six 1-hour sessions of task-oriented circuit gait training including a caregiver over a 12-week period to persons post stroke in the South African public health sector. DESIGN: Stratified, single blinded, randomized controlled trial with three intervention groups. PARTICIPANTS: Persons post stroke ( n = 144, mean age 50 years, 72 women), mean 9.5 weeks post stroke. INTERVENTIONS: Task group ( n = 51)-accompanied by a caregiver; task-oriented circuit gait training (to improve strength, balance, and task performance while standing and walking)...
March 1, 2018: Clinical Rehabilitation
Pamela van der Riet, Tracy Levett-Jones, Helen Courtney-Pratt
Clinical placements are specifically designed to facilitate authentic learning opportunities and are an integral component of undergraduate nursing programs. However, as academics and clinicians frequently point out, clinical placements are fraught with problems that are long-standing and multidimensional in nature. Collaborative placement models, grounded in a tripartite relationship between students, university staff and clinical partners, and designed to foster students' sense of belonging, have recently been implemented to address many of the challenges associated with clinical placements...
March 1, 2018: Nurse Education in Practice
Junkun Tang, Yan Zhou, Liqiang Wan, Farong Huang
Shape-memory polymers (SMPs) possess the capability to change shapes upon stimulation; however, the programming process that determines the temporary shape cannot proceed without external manipulation, which may greatly affect the shape complexity, accuracy, and reproducibility. Here, an automatically programmable SMP (AP-SMP) based on asymmetric swelling of bilayer SMP structures is demonstrated without external manipulation. In the automatic programming process, the AP-SMP can be deformed by the swelling of its hydrophilic hinge film in warm water to a temporary shape, which could be fixed by the glass transition of the two SMP films through cooling and drying in air...
March 8, 2018: Macromolecular Rapid Communications
Anna Lartey, Grace S Marquis, Richmond Aryeetey, Helena Nti
BACKGROUND: Dyslipidemia during childhood has been associated with higher risk of atherosclerosis later in life. Information on the lipid profile of Ghanaian children is scarce. The aim of this study was to assess the lipid profiles of school children between the ages of 9-15 years, living in urban Ghana. METHODS: A total of 802 randomly selected school-age children participated in the Ghana School Survey implemented in Kumasi and Accra, Ghana. A structured questionnaire was used to collect information on child and maternal socio-demographic characteristics (including age, education, and occupation), 7-day food frequency, home and school activity, as well as measurement of weight and standing height...
March 6, 2018: BMC Public Health
Marie Hutchinson, Neil Wendt, Stuart Trevor Smith
The 2011 Productivity Commission report, Caring for Older Australians, observed that as the number of older Australians rises and the demand for aged care services increases, there will be a commensurate increase in demand for a well-trained aged care workforce. One of the significant issues impacting upon the ability of the aged services sector to respond to a growing number of older adults is to attract and retain sufficient numbers of staff. A number of factors are acknowledged to contribute to a failure of the aged care sector to attract and retain workers including: poor sector reputation, poor working conditions, including high client-staff ratios, a lack of career paths and professional development opportunities and low rates of remuneration...
2018: Studies in Health Technology and Informatics
Xue Qu, Huan Liu, Chuchu Zhang, Yu Lei, Miao Lei, Miao Xu, Dawei Jin, Peng Li, Meng Yin, Gregory F Payne, Changsheng Liu
Electrical signals can be imposed with exquisite spatiotemporal control and provide exciting opportunities to create structure and confer function. Here, we report the use of electrical signals to program the fabrication of a chloramine wound dressing with high antimicrobial activity. This method involves two electrofabrication steps: (i) a cathodic electrodeposition of an aminopolysaccharide chitosan triggered by a localized region of high pH; and (ii) an anodic chlorination of the deposited film in the presence of chloride...
March 2, 2018: Acta Biomaterialia
Nadia Shams, Sadia Amjad, Nadeem Yousaf, Waqar Ahmed, Naresh Kumar Seetlani, Shazia Farhat
BACKGROUND: Dengue fever has emerged as an emerging public health issue during last decade bearing significant morbidity and economic burden particularly in third world countries. Current study aims to assess various domains of knowledge of indoor dengue patients.. METHODS: This descriptive crosssectional study was conducted at Medicine dept. Rawal Institute of Health Sciences Islamabad and BBH Rawalpindi over 6 months. One hundred & twenty-five adult indoor confirmed cases of dengue from lower socioeconomic class were included after ethical approval...
January 2018: Journal of Ayub Medical College, Abbottabad: JAMC
Queenie Lin Ling Tan, Lilian Min Yen Chye, Daniella Hui Min Ng, Mei Sian Chong, Tze Pin Ng, Shiou Liang Wee
Purpose: Community-based programs can increase and sustain physical activity participation in older adults, even for those who are physically frail. We studied the feasibility and potential effect of a 12-week structured Functional Power Training (FPT) program involving high velocities and low loads for older adults conducted in a common area of their housing estate. Patients and methods: The structured FPT program was conducted in collaboration with a health promotion social enterprise and a community service provider based in a public housing site...
2018: Clinical Interventions in Aging
Charlotte L Brakenridge, Genevieve N Healy, Elisabeth Ah Winkler, Brianna S Fjeldsoe
BACKGROUND: Wearable activity trackers are now a common feature of workplace wellness programs; however, their ability to impact sitting time (the behavior in which most of the desk-based workday is spent) is relatively unknown. This study evaluated the LUMOback, an activity tracker that targets sitting time, as part of a cluster-randomized workplace sitting intervention in desk-based office workers. OBJECTIVE: Study objectives were to explore: (1) office workers' self-directed LUMOback use, (2) individual-level characteristics associated with LUMOback use, (3) the impact of LUMOback use on activity and sitting behaviors, and (4) office workers' perceived LUMOback acceptability...
March 2, 2018: Interactive Journal of Medical Research
Juh Hyun Shin
PURPOSE: The aim of this study was to examine the effectiveness of an older adult exercise program in a senior-living complex campus. DESIGN: A longitudinal one-group design was used. METHODS: To supply residents with tools to maintain or improve general quality of life, balance, endurance, depression, and functional mobility, the Wellness and Fitness Center at the research setting provided a wide assortment of user-friendly equipment with many options...
March 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
Amanda Hempel Zinglersen, Malte Bjørn Halsteen, Michael Kjær, Anders Karlsen
BACKGROUND: Hospitalization of older medical patients may lead to functional decline. This study investigated whether simultaneously applied neuromuscular electrical stimulation (NMES) can enhance the effects of a functional training program in hospitalized geriatric patients. METHOD: This was a quasi-randomized controlled trial in geriatric hospitalized patients (N = 16, age = 83.1 ± 8.1 years, mean ± SD). The patients performed a simple and time efficient chair-stand based functional exercise program daily, either with (FT + NMES, N = 8) or without (FT, N = 8) simultaneous NMES to the knee extensor muscles...
February 26, 2018: Experimental Gerontology
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