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https://www.readbyqxmd.com/read/28937535/validation-of-a-commercial-assay-and-decision-support-tool-for-routine-paclitaxel-therapeutic-drug-monitoring-tdm
#1
Markus Joerger, Stefanie Kraff, Ulrich Jaehde, Ralf A Hilger, Jodi B Courtney, Daniel J Cline, Sonali Jog, Irina Baburina, M C Miller, Salvatore J Salamone
BACKGROUND: The value of therapeutic drug monitoring (TDM) for paclitaxel was recently demonstrated in the largest TDM trial ever conducted in oncology. The trial demonstrated significant reduction in neuropathy when using TDM. Dose adjustment for paclitaxel was based on time above a threshold concentration (Tc>0.05). Tc>0.05 must be calculated with a pharmacokinetic model and complex non-linear mixed effects (NLME) software. The use of the software and chromatographic methods to measure paclitaxel require specialized expertise...
September 18, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28934966/effectiveness-of-an-interactive-telerehabilitation-system-with-home-based-exercise-training-in-patients-after-total-hip-or-knee-replacement-study-protocol-for-a-multicenter-superiority-no-blinded-randomized-controlled-trial
#2
Sarah Eichler, Sophie Rabe, Annett Salzwedel, Steffen Müller, Josefine Stoll, Nina Tilgner, Michael John, Karl Wegscheider, Frank Mayer, Heinz Völler
BACKGROUND: Total hip or knee replacement is one of the most frequently performed surgical procedures. Physical rehabilitation following total hip or knee replacement is an essential part of the therapy to improve functional outcomes and quality of life. After discharge from inpatient rehabilitation, a subsequent postoperative exercise therapy is needed to maintain functional mobility. Telerehabilitation may be a potential innovative treatment approach. We aim to investigate the superiority of an interactive telerehabilitation intervention for patients after total hip or knee replacement, in comparison to usual care, regarding physical performance, functional mobility, quality of life and pain...
September 21, 2017: Trials
https://www.readbyqxmd.com/read/28934495/a-germline-limited-piggybac-transposase-gene-is-required-for-precise-excision-in-tetrahymena-genome-rearrangement
#3
Lifang Feng, Guangying Wang, Eileen P Hamilton, Jie Xiong, Guanxiong Yan, Kai Chen, Xiao Chen, Wen Dui, Amber Plemens, Lara Khadr, Arjune Dhanekula, Mina Juma, Hung Quang Dang, Geoffrey M Kapler, Eduardo Orias, Wei Miao, Yifan Liu
Developmentally programmed genome rearrangement accompanies differentiation of the silent germline micronucleus into the transcriptionally active somatic macronucleus in the ciliated protozoan Tetrahymena thermophila. Internal eliminated sequences (IES) are excised, followed by rejoining of MAC-destined sequences, while fragmentation occurs at conserved chromosome breakage sequences, generating macronuclear chromosomes. Some macronuclear chromosomes, referred to as non-maintained chromosomes (NMC), are lost soon after differentiation...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28922284/improving-program-nclex-pass-rates-strategies-from-one-state-board-of-nursing
#4
Joan Libner, Sandra Kubala
AIM: This article describes the response of the Illinois Board of Nursing to an escalating number of prelicensure nursing programs with low National Council Licensure Examination (NCLEX) pass rates. The response aligns with stipulations of the Illinois Nurse Practice Act and best practices. BACKGROUND: NCLEX success is crucial to launching the careers of nursing graduates and to maintaining approval status of prelicensure programs by state regulatory bodies. Boards strive to guide programs with low pass rates fairly and consistently...
September 15, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28919842/international-society-of-sports-nutrition-position-stand-nutrient-timing
#5
REVIEW
Chad M Kerksick, Shawn Arent, Brad J Schoenfeld, Jeffrey R Stout, Bill Campbell, Colin D Wilborn, Lem Taylor, Doug Kalman, Abbie E Smith-Ryan, Richard B Kreider, Darryn Willoughby, Paul J Arciero, Trisha A VanDusseldorp, Michael J Ormsbee, Robert Wildman, Mike Greenwood, Tim N Ziegenfuss, Alan A Aragon, Jose Antonio
The International Society of Sports Nutrition (ISSN) provides an objective and critical review regarding the timing of macronutrients in reference to healthy, exercising adults and in particular highly trained individuals on exercise performance and body composition. The following points summarize the position of the ISSN:Nutrient timing incorporates the use of methodical planning and eating of whole foods, fortified foods and dietary supplements. The timing of energy intake and the ratio of certain ingested macronutrients may enhance recovery and tissue repair, augment muscle protein synthesis (MPS), and improve mood states following high-volume or intense exercise...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28905005/management-of-gastric-cancer-in-indian-population
#6
REVIEW
Mohammed Ibrahim, Kissan Gilbert
Adenocarcinoma stands the most common malignancies in the gastric carcinomas and holds a significant mortality and morbidity rates annually, due to the early vague symptoms among the population and hence the delayed presentation at advanced stages of cancer. In India the screening programs for gastric cancer has been a setback due to various logistics reasons and the data available from reporting is also not content. Our study is a review article featuring the management of gastric cancer in the Indian population...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28902999/self-assembled-2d-free-standing-janus-nanosheets-with-single-layer-thickness
#7
Yiyang Lin, Michael R Thomas, Amy Gelmi, Vincent Leonardo, E Thomas Pashuck, Stephanie A Maynard, Ye Wang, Molly M Stevens
We report the thermodynamically controlled growth of solution-processable and free-standing nanosheets via peptide assembly in two dimensions. By taking advantage of self-sorting between peptide β-strands and hydrocarbon chains, we have demonstrated the formation of Janus 2D structures with single-layer thickness, which enable a predetermined surface heterofunctionalization. A controlled 2D-to-1D morphological transition was achieved by subtly adjusting the intermolecular forces. These nanosheets provide an ideal substrate for the engineering of guest components (e...
September 13, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28902268/cystic-echinococcosis-in-south-america-a-call-for-action
#8
Carlos F Pavletic, Edmundo Larrieu, Eduardo A Guarnera, Natalia Casas, Pilar Irabedra, Ciro Ferreira, Julio Sayes, Cesar M Gavidia, Eduardo Caldas, Michael Laurence Zini Lise, Melody Maxwell, Marcos Arezo, Ana Maria Navarro, Marco A N Vigilato, Ottorino Cosivi, Marcos Espinal, Victor J Del Rio Vilas
Cystic echinococcosis (CE) or hydatidosis, a parasitic zoonosis caused by a cestode of the family Taeniidae, species Echinococcus granulosus, is endemic in Argentina, Chile, Peru, Uruguay, and southern Brazil. This report presents CE figures for these five countries in 2009 - 2014 and proposes indicators to measure national control programs. Nearly 5 000 new CE cases were diagnosed annually in the five countries during the study period. The average case fatality rate was 2.9%, which suggests that CE led to approximately 880 deaths in these countries during the 6-year period...
August 21, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28899341/development-of-a-home-based-training-program-for-post-ward-geriatric-rehabilitation-patients-with-cognitive-impairment-study-protocol-of-a-randomized-controlled-trail
#9
Martin Bongartz, Rainer Kiss, Phoebe Ullrich, Tobias Eckert, Jürgen Bauer, Klaus Hauer
BACKGROUND: Geriatric patients with cognitive impairment (CI) show an increased risk for a negative rehabilitation outcome and reduced functional recovery following inpatient rehabilitation. Despite this obvious demand, evidence-based training programs at the transition from rehabilitation to the home environments are lacking. The aim of this study is to evaluate the efficacy of a feasible and cost-effective home-based training program to improve motor performance and to promote physical activity, specifically-tailored for post-ward geriatric patients with CI...
September 12, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28890857/how-long-should-the-fully-hillside-closed-forest-protection-be-implemented-on-the-loess-plateau-shaanxi-china
#10
Lin Hou, Sijia Hou
BACKGROUND: Restoration of degraded forest ecosystem is crucial for regional sustainable development. To protect the country's fragile and fragmented environment, the Chinese government initiated an ecological engineering project, the Natural Forest Protection Program, in seventeen provinces in China beginning in 1998. Fully hillside-closed forest protection (vegetation restoration naturally without any artificial disturbance) was one of vital measures of the Natural Forest Protection Program applied nation wide...
2017: PeerJ
https://www.readbyqxmd.com/read/28883912/infection-control-at-an-urban-hospital-in-manila-philippines-a-systems-engineering-assessment-of-barriers-and-facilitators
#11
Kaitlin F Mitchell, Anna K Barker, Cybele L Abad, Nasia Safdar
BACKGROUND: Healthcare facilities in low- and middle-income countries, including the Philippines, face substantial challenges in achieving effective infection control. Early stages of interventions should include efforts to understand perceptions held by healthcare workers who participate in infection control programs. METHODS: We performed a qualitative study to examine facilitators and barriers to infection control at an 800-bed, private, tertiary hospital in Manila, Philippines...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28883555/associations-between-trunk-muscle-morphology-strength-and-function-in-older-adults
#12
Behnaz Shahtahmassebi, Jeffrey J Hebert, Mark D Hecimovich, Timothy J Fairchild
Skeletal muscle plays an important role in performing activities of daily living. While the importance of limb musculature in performing these tasks is well established, less research has focused on the muscles of the trunk. The purpose of the current study therefore, was to examine the associations between functional ability and trunk musculature in sixty-four community living males and females aged 60 years and older. Univariate and multivariate analyses of the a priori hypotheses were performed and reported with correlation coefficients and unstandardized beta coefficients (β) respectively...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28864807/how-research-training-will-shape-the-future-of-dental-oral-and-craniofacial-research
#13
Rena N D'Souza, John S Colombo
This is a critical time in the history of the dental profession for it to fully embrace the responsibility to safeguard its reputation as a learned profession. In this golden era of scientific and technological advances, opportunities abound to create new diagnostics, preventions, treatments, and cures to improve oral health. Dental schools are the largest national resource entrusted with the responsibility to educate, train, and retain oral health researchers who can leverage such technologies and research opportunities that will benefit the profession at large as well as patients...
September 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28860429/-the-overview-of-two-programs-to-support-cancer-survivor-s-advocacy-by-cancernet-japan
#14
Sachiko Kawakami, Meiko Ohtomo, Chiaki Ogino, Toshiro Konishi, Satoru Iwase
In 2016, the Cancer Control Act was revised, with emphasis on support for people living with cancer, the public's understanding of cancer patients, continuation of employment of cancer patients and cancer education, etc, was added. In order to make policies effective, it is necessary for society to listen to the voices of cancer survivor and to know the current situation of issues they face on. We, CancerNet Japan have been supporting cancer patients through the 2 projects "Breast cancer Experienced Coordinator(BEC)Training Course", started in 2007 and "Over Cancer Together(OCT)Campaign", started in 2013...
August 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28858051/long-term-changes-in-jump-performance-and-maximum-strength-in-a-cohort-of-ncaa-division-i-women-s-volleyball-athletes
#15
Ashley A Kavanaugh, Satoshi Mizuguchi, William A Sands, Michael W Ramsey, Michael H Stone
The purpose of this investigation was to quantify the magnitude of change in maximal strength and jumping abilities over approximately one, two, and three years of supervised sport and resistance training in NCAA Division I women's volleyball athletes. This was an exploratory study on a cohort of women's volleyball athletes (n=29) split into three groups based on length of time spent in a supervised resistance training program: group 1 (n=11): 0.7±0.3 yrs, group 2 (n=9): 1.6±0.2 yrs, and group 3 (n=9): 2...
August 26, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28836702/results-of-a-36-year-surveillance-program-for-ulcerative-colitis-associated-neoplasia-in-the-japanese-population
#16
Junko Kishikawa, Hata Keisuke, Shinsuke Kazama, Hiroyuki Anzai, Takahide Shinagawa, Koji Murono, Manabu Kaneko, Kazuhito Sasaki, Koji Yasuda, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Hiroaki Nozawa, Soichiro Ishihara, Teppei Morikawa, Masashi Fukayama, Toshiaki Watanabe
BACKGROUND: Surveillance colonoscopy has been performed for patients with long-standing ulcerative colitis, who have an increased risk for colorectal cancer. The aim of this study was to determine the incidence of and the risk factors for neoplasia. METHODS: We evaluated 289 ulcerative colitis patients who underwent surveillance colonoscopy between January1979 and December 2014. The cumulative incidence of neoplasia and its risk factors were investigated. The clinical stage and overall survival were compared between the surveillance and non-surveillance groups...
August 24, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28835251/noise-assisted-multivariate-empirical-mode-decomposition-for-multichannel-emg-signals
#17
Yi Zhang, Peng Xu, Peiyang Li, Keyi Duan, Yuexin Wen, Qin Yang, Tao Zhang, Dezhong Yao
BACKGROUND: Ensemble Empirical Mode Decomposition (EEMD) has been popularised for single-channel Electromyography (EMG) signal processing as it can effectively extract the temporal information of the EMG time series. However, few papers examine the temporal and spatial characteristics across multiple muscle groups in relation to multichannel EMG signals. EXPERIMENT: The experimental data was obtained from the Center for Machine Learning and Intelligent Systems, University of California Irvine (UCI)...
August 23, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28832747/pre-participation-physical-fitness-does-not-influence-adherence-to-a-supervised-exercise-program
#18
Fábio Akio Nishijuka, Christina Grüne de Souza E Silva, Carlos Vieira Duarte, Claudio Gil Soares de Araújo
Background: Exercise-based cardiac rehabilitation tends to reduce mortality. However, it requires medium/long-term adherence to regular physical exercise. It is relevant to identify the variables that affect adherence to an supervised exercise program (SEP). Objective: To evaluate the influence of pre-participation levels of aerobic and non-aerobic physical fitness components in medium-term adherence to SEP. Methods: A total of 567 SEP participants (65 ± 12 years) (68% men) were studied...
August 17, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28832427/resistance-training-reduces-inflammation-and-fatigue-and-improves-physical-function-in-older-breast-cancer-survivors
#19
Monica C Serra, Alice S Ryan, Heidi K Ortmeyer, Odessa Addison, Andrew P Goldberg
OBJECTIVE: Resistance training (RT) reduces fatigue and improves physical function and quality of life (QOL) in breast cancer survivors (BCS). This may be related to reductions in systemic and tissue-specific inflammation. This pilot study examines the hypothesis that RT induces changes in systemic and tissue-specific inflammation that contribute to improvements in physical and behavioral function in postmenopausal BCS. METHODS: Eleven BCS (60 ± 2 years old, body mass index 30 ± 1 kg/m, mean ± SEM) underwent assessments of fatigue (Piper Fatigue Scale), physical function, QOL (SF-36), glucose and lipid metabolism, and systemic, skeletal muscle, and adipose tissue inflammation (n = 9) before and after 16 weeks of moderate-intensity whole-body RT...
August 21, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28827207/effect-of-modified-otago-exercises-on-postural-balance-fear-of-falling-and-fall-risk-in-older-fallers-with-knee-osteoarthritis-and-impaired-gait-and-balance-a-secondary-analysis
#20
Sumaiyah Mat, Chin Teck Ng, Pey June Tan, Norlisah Ramli, Farhana Fadzli, Faizatul Izza Rozalli, Mazlina Mazlan, Keith D Hill, Maw Pin Tan
BACKGROUND: Osteoarthritis (OA) is considered an established risk factor for falls. Published studies evaluating secondary falls prevention strategies among OA sufferers are limited. OBJECTIVE: To evaluate the effect of a personalized home-based exercise program to improve postural balance, fear of falling and falls risk in older fallers with knee OA and gait and balance problems. DESIGN: Randomized controlled trial SETTING: University of Malaya Medical Centre PARTICIPANT: Fallers who had both radiological OA and a Timed Up and Go (TUG) score of over 13...
August 18, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
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