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https://www.readbyqxmd.com/read/28439833/srnatoolboxvm-small-rna-analysis-in-a-virtual-machine
#1
Cristina Gómez-Martín, Ricardo Lebrón, Antonio Rueda, José L Oliver, Michael Hackenberg
High-throughput sequencing (HTS) data for small RNAs (noncoding RNA molecules that are 20-250 nucleotides in length) can now be routinely generated by minimally equipped wet laboratories; however, the bottleneck in HTS-based research has shifted now to the analysis of such huge amount of data. One of the reasons is that many analysis types require a Linux environment but computers, system administrators, and bioinformaticians suppose additional costs that often cannot be afforded by small to mid-sized groups or laboratories...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28434144/peer-coaching-interventions-for-parents-of-children-with-type-1-diabetes
#2
REVIEW
Carrie Tully, Caitlin Shneider, Maureen Monaghan, Marisa E Hilliard, Randi Streisand
PURPOSE OF REVIEW: Peer support is a promising model of providing psychosocial support to parents of children with type 1 diabetes. This review seeks to discuss the findings of the existing literature in peer coaching as it relates to parents and diabetes as well as to identify gaps in knowledge for future intervention development and implementation. RECENT FINDINGS: Peer support programs vary widely with regard to recruitment, training, and delivery protocols. Across most programs, ongoing support and supervision are provided to peer coaches...
June 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28429069/mupexi-prediction-of-neo-epitopes-from-tumor-sequencing-data
#3
Anne-Mette Bjerregaard, Morten Nielsen, Sine Reker Hadrup, Zoltan Szallasi, Aron Charles Eklund
Personalization of immunotherapies such as cancer vaccines and adoptive T cell therapy depends on identification of patient-specific neo-epitopes that can be specifically targeted. MuPeXI, the mutant peptide extractor and informer, is a program to identify tumor-specific peptides and assess their potential to be neo-epitopes. The program input is a file with somatic mutation calls, a list of HLA types, and optionally a gene expression profile. The output is a table with all tumor-specific peptides derived from nucleotide substitutions, insertions, and deletions, along with comprehensive annotation, including HLA binding and similarity to normal peptides...
April 20, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28418066/a-national-survey-on-the-effect-of-the-geriatric-academic-career-award-in-advancing-academic-geriatric-medicine
#4
Kevin T Foley, Clare C Luz, Katherine V Hanson, Yuning Hao, Elisia M Ray
A workforce that understands principles of geriatric medicine is critical to addressing the care needs of the growing elderly population. This will be impossible without a substantial increase in academicians engaged in education and aging research. Limited support of early-career clinician-educators is a major barrier to attaining this goal. The Geriatric Academic Career Award (GACA) was a vital resource that benefitted 222 junior faculty members. GACA availability was interrupted in 2006, followed by permanent discontinuation after the Geriatrics Workforce Education Program (GWEP) subsumed it in 2015, leaving aspiring clinician-educators with no similar alternatives...
April 18, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28416201/the-impact-of-the-nurse-faculty-scholars-program-on-schools-of-nursing
#5
Angela Barron McBride, Jacquelyn Campbell, Taura Barr, Joanne Duffy, Emily Haozous, Jennifer Mallow, Georgia Narsavage, Nancy Ridenour, Laurie Theeke
BACKGROUND: The Robert Wood Johnson Foundation Nurse Faculty Scholars program was conceptualized as not only promoting the growth and development of early-career faculty but as enhancing the research infrastructure of scholars' schools of nursing. PURPOSE: At the completion of the scholars' three years of support, deans/directors were asked to provide feedback regarding the institutional impact of the scholars' participation in the program. METHODS: Phone interviews were conducted on the first five completed cohorts and a six-item questionnaire was developed to obtain some quantitative data...
March 25, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28415885/fatigue-and-pain-limit-independent-mobility-and-physiotherapy-after-hip-fracture-surgery
#6
Kristine H Münter, Christopher G Clemmesen, Nicolai B Foss, Henrik Palm, Morten T Kristensen
PURPOSE: The patient's ability to complete their planned physiotherapy session after hip fracture surgery has been proposed as an independent predictor for achieving basic mobility independency upon hospital discharge. However, knowledge of factors limiting mobility is sparse. We therefore examined patient reported factors limiting ability to complete planned physiotherapy sessions as well as limitations for not achieving independency in basic mobility early after hip fracture surgery...
April 17, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28410327/the-activpaltm-accurately-classifies-activity-intensity-categories-in-healthy-adults
#7
Kate Lyden, Sarah Kozey Keadle, John Staudenmayer, Patty S Freedson
The activPAL (AP) monitor is well established for distinguishing sitting, standing, and stepping time. However, its validity in predicting time in physical activity intensity categories in a free-living environment has not been determined. PURPOSE: This study aimed to determine the validity of the AP in estimating time spent in sedentary, light, and moderate-to-vigorous physical activity (MVPA) in a free-living environment. METHODS: Thirteen participants (mean ± SD age = 24...
May 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28409030/effects-of-multicomponent-exercise-on-functional-and-cognitive-parameters-of-hypertensive-patients-a-quasi-experimental-study
#8
Hélio José Coelho Junior, Bruno Rodrigues, Daniele Jardim Feriani, Ivan de Oliveira Gonçalves, Ricardo Yukio Asano, Samuel da Silva Aguiar, Marco Carlos Uchida
Purpose. The present study aimed to investigate the impact of a 6-month multicomponent exercise program (MCEP) on physical function and cognitive parameters of normotensive (NTS) and hypertensive (HTS) older patients and verify if age can influence the adaptations in response to the exercise. Methods. A total of 218 subjects, 101 NTS and 117 HTS, were recruited and underwent functional and cognitive evaluations before and after six months of a MCEP. The program of exercise was performed twice a week, for 26 weeks...
2017: Journal of Aging Research
https://www.readbyqxmd.com/read/28403339/effective-universal-coverage-of-diabetes-mellitus-type-2-in-chile
#9
Sara Guerrero-Núñez, Sandra Valenzuela-Suazo, Patricia Cid-Henríquez
Objective: determine the prevalence of Effective Universal Coverage of Diabetes Mellitus Type 2 in Chile and its relation with the variables: Health Care Coverage of Diabetes Mellitus Type 2; Average of diabetics with metabolic control in 2011-2013; Mortality Rate for Diabetes Mellitus; and Percentage of nurses participating in the Cardiovascular Health Program. Method: cross-sectional descriptive study with ecological components that uses documentary sources of the Ministry of Health...
April 6, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28402643/coverage-dependent-anchoring-of-4-4-biphenyl-dicarboxylic-acid-to-coo-111-thin-films
#10
Susanne Mohr, Tobias Schmitt, Tibor Döpper, Feifei Xiang, Matthias Schwarz, Andreas Görling, M Alexander Schneider, Jörg Libuda
We investigated the adsorption behavior of 4,4'-biphenhyl dicarboxylic acid (BDA) on well-ordered CoO(111) films grown on Ir(100) as a function of coverage and temperature using time-resolved and temperature-programmed infrared reflection absorption spectroscopy (TR-IRAS, TP-IRAS) in combination with density functional theory (DFT) and scanning tunneling microscopy (STM) under ultrahigh vacuum (UHV) conditions. To compare the binding behavior of BDA as a function of the oxide film thickness, three different CoO(111) film thicknesses were explored: films of about 20 bilayers (BLs) (approximately 5 nm), 2 BLs, and 1 BL...
April 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28399000/overcoming-health-system-challenges-for-women-and-children-living-with-hiv-through-the-global-plan
#11
Surbhi Modi, Tegan Callahan, Jessica Rodrigues, Mwikemo D Kajoka, Helen M Dale, Judite O Langa, Marilena Urso, Matsepeli I Nchephe, Helene Bongdene, Sostena Romano, Laura N Broyles
To meet the ambitious targets set by the Global Plan Towards the Elimination of New HIV Infections Among Children by 2015 and Keeping Their Mothers Alive (Global Plan), the initial 22 priority countries quickly developed innovative approaches for overcoming long-standing health systems challenges and providing HIV testing and treatment to pregnant and breastfeeding women and their infants. The Global Plan spurred programs for prevention of mother-to-child HIV transmission to integrate HIV-related care and treatment into broader maternal, newborn, and child health services; expand the effectiveness of the health workforce through task sharing; extend health services into communities; strengthen supply chain and commodity management systems; reduce diagnostic and laboratory hurdles; and strengthen strategic supervision and mentorship...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28394883/pdgf-signalling-guides-neural-crest-contribution-to-the-haematopoietic-stem-cell-specification-niche
#12
Erich W Damm, Wilson K Clements
Haematopoietic stem cells (HSCs) support maintenance of the haematopoietic and immune systems throughout the life of vertebrates, and are the therapeutic component of bone marrow transplants. Understanding native specification of HSCs, to uncover key signals that might help improve in vitro directed differentiation protocols, has been a long-standing biomedical goal. The current impossibility of specifying true HSCs in vitro suggests that key signals remain unknown. We speculated that such signals might be presented by surrounding 'niche' cells, but no such cells have been defined...
April 10, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28392859/whole-body-vibration-training-during-a-low-frequency-outpatient-exercise-training-program-in-chronic-obstructive-pulmonary-disease-patients-a-randomized-controlled-trial
#13
Marc Spielmanns, Rainer Gloeckl, Jana Marie Gropp, Christoph Nell, Andreas Rembert Koczulla, Tobias Boeselt, Jan Hendrik Storre, Wolfram Windisch
BACKGROUND: The aim of the study was to investigate whether whole-body vibration training (WBVT) can be applied beneficially within an outpatient low frequency exercise program. METHODS: In a prospective, controlled, randomized study, WBVT effectiveness and safety were investigated in COPD stage II-IV patients undergoing a 3-month training program. Participants took part in a 90-min circuit training once a week. On top patients were randomized to either perform squats with WBVT, or without (conventional training group (CTG))...
May 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28390503/randomized-controlled-trial-of-a-computerized-interactive-media-based-problem-solving-treatment-for-depression
#14
Luis R Sandoval, Jay C Buckey, Ricardo Ainslie, Martin Tombari, William Stone, Mark T Hegel
This study evaluated the efficacy of an interactive media-based, computer-delivered depression treatment program (imbPST) compared to a no-treatment control condition (NTC) in a parallel-group, randomized, controlled trial conducted in an outpatient psychiatric research clinic. 45 adult participants with major depressive disorder or dysthymia were randomized to receive either 6 weekly sessions of imbPST or no treatment (No Treatment Control; NTC). The primary outcome measure was the Beck Depression Inventory II (BDI-II)...
May 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28379873/happy-despite-pain-a-randomized-controlled-trial-of-an-8-week-internet-delivered-positive-psychology-intervention-for-enhancing-well-being-in-patients-with-chronic-pain
#15
Madelon L Peters, Elke Smeets, Marion Feijge, Gerard van Breukelen, Gerhard Andersson, Monica Buhrman, Steven J Linton
OBJECTIVES: There is preliminary evidence for the efficacy of positive psychology interventions for pain management. The current study examined the effects of an internet-based positive psychology self-help program for patients with chronic musculoskeletal pain and compared it with an internet-based cognitive behavioural program. METHODS: A randomized controlled trial was carried out with three conditions: an internet-delivered positive psychology program, an internet-delivered cognitive behavioural program and waitlist control...
April 4, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28379180/eliminating-iodine-deficiency-in-china-achievements-challenges-and-global-implications
#16
Dianjun Sun, Karen Codling, Suying Chang, Shubin Zhang, Hongmei Shen, Xiaohui Su, Zupei Chen, Robert W Scherpbier, Jun Yan
The prevention of iodine deficiency through salt iodization has been recognized as a global success story, and China stands at the forefront of this achievement with one of the most successful programs in the world. High level political commitment, national mandatory legislation, a state-managed edible salt industry and a complex and highly sophisticated surveillance system have facilitated the success of the program. Challenges have arisen however, including: (i) concern that adequate iodine status in pregnant women cannot be achieved without causing above adequate iodine intakes in children; (ii) declining iodine intake as a result of reductions in salt consumption and increased consumption of processed foods, which may not be made with iodized salt; (iii) the existence of areas with high iodine content in the water; and (iv) declines in household use of iodized salt due to concerns about excess iodine intake and thyroid disease...
April 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28377944/are-prior-experience-and-subspecialty-training-time-predictive-of-pediatric-anesthesia-exit-exam-scores-for-rotating-ca-2-residents
#17
Jonathon H Nelson, Nina Deutsch, Ira T Cohen, Srijaya K Reddy
BACKGROUND: Anesthesiology residency programs commonly have rotations at free-standing children's hospitals to provide and/or supplement their residents' training in pediatric anesthesia. Length and timing of these rotations differ from program to program as can their residents' existing medical knowledge and clinical skills. We predicted that residents with prior pediatric anesthesia experience, who rotate at our pediatric institution for two consecutive months, will score higher on an exit exam compared to residents without prior pediatric experience or those that only rotate for one month...
January 2017: Journal of Education in Perioperative Medicine: JEPM
https://www.readbyqxmd.com/read/28377916/empowering-the-physiotherapy-profession-in-ethiopia-through-leadership-development-within-the-doctoring-process
#18
Cheryl Burditt Footer, Hailu Seifu Tsegaye, Tesfaye Asnake Yitnagashaw, Wintana Mekonnen, Tizita Destaw Shiferaw, Endashaw Abera, Alice Davis
Ethiopia recently introduced the Doctor of Physiotherapy (DPT) degree at Addis Ababa University as a mechanism to increase the work force capacity of primary care providers in the health sector. The DPT program was supported by an international academic partnership and was designed to empower physiotherapists as leaders to move the profession forward. The curriculum was framed by core pedagogical principles and strategies and was phased into two programs. First, the 4-year Advanced Standing DPT program focused on developing registered Ethiopian physiotherapists with Bachelor of Science degrees as academic faculty...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28377377/mechanisms-in-endocrinology-neurodevelopmental-disorders-in-children-born-to-mothers-with-thyroid-dysfunction-evidence-of-fetal-programming
#19
Stine Linding Andersen, Allan Carle, Jesper Scot Karmisholt, Inge Bülow Pedersen, Stig Andersen
Fetal programming is a long-standing, but still evolving, concept that links exposures during pregnancy to the later development of disease in the offspring. A fetal programming effect has been considered within different endocrine axes and in relation to different maternal endocrine diseases. In this critical review, we describe and discuss the hypothesis of fetal programming by maternal thyroid dysfunction in the context of fetal brain development and neurodevelopmental disorders in the offspring. Thyroid hormones are important regulators of early brain development, and evidence from experimental and observational human studies have demonstrated structural and functional abnormalities in the brain caused by lack or excess of thyroid hormone during fetal brain development...
April 4, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28376057/measurement-as-a-performance-driver-the-case-for-a-national-measurement-system-to-improve-patient-safety
#20
Thomas R Krause, Kristen J Bell, Peter Pronovost, Jason M Etchegaray
Safety metrics in healthcare settings stand apart from those in all other industries. Despite improvements in the measurement and prevention of adverse health outcomes following the 1999 Institute of Medicine report, no fully operational national-level program for monitoring patient harm exists. Here, we review the annual rate of fatal adverse events in healthcare settings in the United States on the basis of previous research, assess the current state of measurements of patient harm, propose a national standard to both quantify harm and act as a performance driver for improved safety, and discuss additional considerations such as accountability and implications for tort reform under this standard...
April 4, 2017: Journal of Patient Safety
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