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https://www.readbyqxmd.com/read/28213690/anticipatory-postural-adjustments-associated-with-reaching-movements-are-programmed-according-to-the-availability-of-visual-information
#1
Roberto Esposti, Carlo Bruttini, Francesco Bolzoni, Paolo Cavallari
During goal-directed arm movements, the eyes, head, and arm are coordinated to look at and reach the target. We examined whether the expectancy of visual information about the target modifies Anticipatory Postural Adjustments (APAs). Ten standing subjects had to (1) move the eyes, head and arm, so as to reach, with both gaze and index-finger, a target of known position placed outside their visual field (Gaze-Reach); (2) look at the target while reaching it (Reach in Full Vision); (3) keep the gaze away until having touched it (Reach then Gaze) and (4) just Gaze without Reach the target...
February 17, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28206847/vocation-belongingness-and-balance-a-qualitative-study-of-veterinary-student-well-being
#2
Jacqueline M Cardwell, Elisa G Lewis
An elevated risk for suicide among veterinarians has stimulated research into the mental health of the veterinary profession, and more recently attention has turned to the veterinary student population. This qualitative study sought to explore UK veterinary students' perceptions and experiences of university life, and to consider how these may affect well-being. Semi-structured interviews were conducted with 18 students from a single UK school who were purposively selected to include perspectives from male, female, graduate-entry, standard-entry (straight from high school), and widening participation students across all 5 years of the program...
2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28203108/a-review-of-screening-strategies-for-cervical-cancer-in-human-immunodeficiency-virus-positive-women-in-sub-saharan-africa
#3
REVIEW
Manuela Viviano, Pierre DeBeaudrap, Pierre-Marie Tebeu, Jovanny T Fouogue, Pierre Vassilakos, Patrick Petignat
Cervical cancer (CC) is a leading cause of cancer-related death and a major public health issue in sub-Saharan Africa. This heavy burden parallels that of the human immunodeficiency virus (HIV) infection, which increases the risk of developing CC. Despite the progressive reduction of HIV prevalence in the past decade, the CC incidence and mortality rates in sub-Saharan Africa remain high. The heterogeneity of the distribution of the two diseases in the African continent, together with the different availability of human and material resources, stands in the way of finding an appropriate screening strategy...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28198722/triad-viii-nationwide-multicenter-evaluation-to-determine-whether-patient-video-testimonials-can-safely-help-ensure-appropriate-critical-versus-end-of-life-care
#4
Ferdinando L Mirarchi, Timothy E Cooney, Arvind Venkat, David Wang, Thaddeus M Pope, Abra L Fant, Stanley A Terman, Kevin M Klauer, Monica Williams-Murphy, Michael A Gisondi, Brian Clemency, Ankur A Doshi, Mari Siegel, Mary S Kraemer, Kate Aberger, Stephanie Harman, Neera Ahuja, Jestin N Carlson, Melody L Milliron, Kristopher K Hart, Chelsey D Gilbertson, Jason W Wilson, Larissa Mueller, Lori Brown, Bradley D Gordon
OBJECTIVE: End-of-life interventions should be predicated on consensus understanding of patient wishes. Written documents are not always understood; adding a video testimonial/message (VM) might improve clarity. Goals of this study were to (1) determine baseline rates of consensus in assigning code status and resuscitation decisions in critically ill scenarios and (2) determine whether adding a VM increases consensus. METHODS: We randomly assigned 2 web-based survey links to 1366 faculty and resident physicians at institutions with graduate medical education programs in emergency medicine, family practice, and internal medicine...
February 14, 2017: Journal of Patient Safety
https://www.readbyqxmd.com/read/28192379/compensatory-saccades-are-associated-with-physical-performance-in-older-adults-data-from-the-baltimore-longitudinal-study-of-aging
#5
Yanjun Xie, Eric R Anson, Eleanor M Simonsick, Stephanie A Studenski, Yuri Agrawal
OBJECTIVE: To determine whether compensatory saccade metrics observed in the video head impulse test, specifically saccade amplitude and latency, predict physical performance. STUDY DESIGN: Cross-sectional analysis of the Baltimore Longitudinal Study of Aging, a prospective cohort study. SETTING: National Institute on Aging Intramural Research Program Clinical Research Unit in Baltimore, Maryland. PATIENTS: Community-dwelling older adults...
March 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28192178/identification-and-characterization-of-the-expression-profile-of-the-micrornas-in-the-amazon-species-colossoma-macropomum-by-next-generation-sequencing
#6
Fátima Gomes, Luciana Watanabe, Sérgio Nozawa, Layanna Oliveira, Jedson Cardoso, João Vianez, Márcio Nunes, Horacio Schneider, Iracilda Sampaio
Colossoma macropomum is a resistant species native of Amazonas and Orinoco river basins. It is regarded as the second largest finfish of Solimões and Amazon rivers, representing a major fishery resource in Amazonas and an important species in tropical aquaculture. MicroRNAs are non-coding endogenous riboregulators of nearly 22 nucleotides that play a key role in post-transcriptional gene regulation of several organisms. We analyzed samples of liver and skin from specimens of C. macropomum using next generation sequencing...
February 10, 2017: Genomics
https://www.readbyqxmd.com/read/28188124/commencing-and-persisting-with-a-web-based-cognitive-behavioral-intervention-for-insomnia-a-qualitative-study-of-treatment-completers
#7
Charles Chan, Stacey West, Nick Glozier
BACKGROUND: Computerized cognitive behavioral therapy for insomnia (CCBT-I) has a growing evidence base as a stand-alone intervention, but it is less clear what factors may limit its acceptability and feasibility when combined with clinical care. OBJECTIVE: The purpose of this study was to explore barriers and facilitators to use of an adjunctive CCBT-I program among depressed patients in a psychiatric clinic by using both quantitative and qualitative approaches...
February 10, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28174231/should-bariatric-surgery-be-performed-in-adolescents
#8
REVIEW
Andrew J Beamish, Thomas Reinehr
Adolescent obesity has markedly increased worldwide in both its extent and prevalence in recent decades and obesity prevention strategies are failing. As a result, effective treatment strategies are urgently needed. As behavioral and pharmacological treatment approaches have only moderate effects in severe obesity, bariatric surgery has begun to emerge as a treatment option. In this debate article, we offer arguments opposing and supporting bariatric surgery in the treatment of severe obesity in adolescents...
April 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28159717/generation-of-anti-inflammatory-macrophages-for-implants-and-regenerative-medicine-using-self-standing-release-systems-with-a-phenotype-fixing-cytokine-cocktail-formulation
#9
Vladimir Riabov, Fabián Salazar, Su Su Htwe, Alexandru Gudima, Christina Schmuttermaier, Julien Barthes, Helena Knopf-Marques, Harald Klüter, Amir M Ghaemmaghami, Nihal Engin Vrana, Julia Kzhyshkowska
: The immediate tissue microenvironment of implanted biomedical devices and engineered tissues is highly influential on their long term fate and efficacy. The creation of a long-term anti-inflammatory microenvironment around implants and artificial tissues can facilitate their integration. Macrophages are highly plastic cells that define the tissue reactions on the implanted material. Local control of macrophage phenotype by long-term fixation of their healing activities and suppression of inflammatory reactions are required to improve implant acceptance...
February 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28158960/short-term-clinical-effects-of-dry-needling-combined-with-physical-therapy-in-patients-with-chronic-postsurgical-pain-following-total-knee-arthroplasty-case-series
#10
Rodrigo Núñez-Cortés, Carlos Cruz-Montecinos, Álvaro Vásquez Rosel, Orlando Paredes Molina, Antonio Cuesta-Vargas
Study Design Case series. Background The purpose of this case series is to describe a combined program of dry needling (DN) and therapeutic exercise in a small group of patients with persistent pain post total knee arthroplasty. Case Description Fourteen total knee arthroplasty patients with persistent post-surgical pain and myofascial trigger points non-responsive to treatment with conventional physical therapy or medications received dry needling treatment in combination with therapeutic exercises for four weeks...
February 3, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28156486/referral-patterns-among-patients-with-metastatic-breast-cancer-in-an-integrated-palliative-care-program
#11
Jeffrey Belkora, Melanie Catherine Majure, Amy Jo Chien, Michelle E Melisko, Hope S Rugo, Michael W Rabow
: 163 Background: ASCO recommends palliative care (PC) concurrently with oncologic treatment for patients with metastatic disease and there is emerging data about the benefits of early PC. However, little is known about referral patterns to specialty PC among patients who die of metastatic breast cancer. METHODS: After years of offering a stand-alone outpatient PC consult service in our comprehensive cancer center, we established an integrated PC program in breast oncology (the "Advanced Breast Cancer (ABC) Program") with a care coordinator, PC physician, and co-location with oncology...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152981/classifying-kinase-conformations-using-a-machine-learning-approach
#12
Daniel Ian McSkimming, Khaled Rasheed, Natarajan Kannan
BACKGROUND: Signaling proteins such as protein kinases adopt a diverse array of conformations to respond to regulatory signals in signaling pathways. Perhaps the most fundamental conformational change of a kinase is the transition between active and inactive states, and defining the conformational features associated with kinase activation is critical for selectively targeting abnormally regulated kinases in diseases. While manual examination of crystal structures have led to the identification of key structural features associated with kinase activation, the large number of kinase crystal structures (~3,500) and extensive conformational diversity displayed by the protein kinase superfamily poses unique challenges in fully defining the conformational features associated with kinase activation...
February 2, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28151487/saturday-driving-restrictions-fail-to-improve-air-quality-in-mexico-city
#13
Lucas W Davis
Policymakers around the world are turning to license-plate based driving restrictions in an effort to address urban air pollution. The format differs across cities, but most programs restrict driving once or twice a week during weekdays. This paper focuses on Mexico City, home to one of the oldest and best-known driving restriction policies. For almost two decades Mexico City's driving restrictions applied during weekdays only. This changed recently, however, when the program was expanded to include Saturdays...
February 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28149500/pragmatic-trials-may-help-to-identify-effective-strategies-to-reduce-nursing-home-antipsychotic-medication-use
#14
EDITORIAL
Rosa R Baier, Vincent Mor
Despite widespread agreement that nursing homes' use of antipsychotic medications for residents without specific psychiatric diagnoses is a marker of poor quality of care, prevalence remains high. Additionally, variation suggests continued opportunity to improve care even in countries, like the United States, that have long-standing policies designed to decrease antipsychotic medication use. In a recent Israel Journal of Health Policy Research article, Frankenthal et al. presented results linking increased antipsychotic medication use prevalence in Tel Aviv nursing homes with facility characteristics, including some that "undermine quality of care," and called for increased national focus on this area...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28148227/effective-team-based-primary-care-observations-from-innovative-practices
#15
Edward H Wagner, Margaret Flinter, Clarissa Hsu, DeAnn Cromp, Brian T Austin, Rebecca Etz, Benjamin F Crabtree, MaryJoan D Ladden
BACKGROUND: Team-based care is now recognized as an essential feature of high quality primary care, but there is limited empiric evidence to guide practice transformation. The purpose of this paper is to describe advances in the configuration and deployment of practice teams based on in-depth study of 30 primary care practices viewed as innovators in team-based care. METHODS: As part of LEAP, a national program of the Robert Wood Johnson Foundation, primary care experts nominated 227 innovative primary care practices...
February 2, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28141711/an-8-year-old-boy-with-treatment-resistant-encopresis
#16
Martin T Stein, Marc A Benninga, Barbara T Felt
Paul is an 8-year-old boy with a long-standing history of encopresis and enuresis. Potty training was initiated when he was 2 years old. At this time, his mother was absent from the home for 6 weeks when she cared for her ill father in a different city. The process of teaching Paul to use the bathroom was described as "inconsistent" due to multiple caretakers.Paul never successfully mastered bowel and bladder control. He continues to wet and soil his clothes on a daily basis at home and school. According to his parents, he does not accept responsibility and comments about his soiling such as, "I didn't do it; someone else must have put it there...
February 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28137531/effects-of-a-12-week-program-of-tai-chi-exercise-on-the-kidney-disease-quality-of-life-and-physical-functioning-of-patients-with-end-stage-renal-disease-on-hemodialysis
#17
Jo-Han Chang, Malcolm Koo, Sheng-Wen Wu, Chiu-Yuan Chen
BACKGROUND: Previous studies have shown that exercise training in patients with end-stage renal disease could improve their physical functioning and quality of life. Nevertheless, few studies have evaluated the effects of Tai Chi exercise in patients on hemodialysis. OBJECTIVE: To investigate the effects of a Tai Chi exercise intervention on the quality of life and physical functioning in end-stage renal disease patients on hemodialysis. DESIGN: A pre-post experimental design...
February 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28135226/differences-by-ending-rounds-and-other-rounds-in-time-motion-analysis-of-mixed-martial-arts-implications-for-assessment-and-training
#18
Bianca Miarka, Ciro José Brito, Danilo Gomes Moreira, John Amtmann
This study aimed to support training program development through the comparison of performance analysis of professionals mixed martial arts (MMA) athletes in the bouts that were not finished by points. Using digital recordings of each bout, we analyzed 1,564 rounds (678 bouts) which were separated by Ending and other Rounds. Our results indicated that KO/TKO is the main outcome that defines the ending round (≈60%), however, there is a higher frequency of ending by submission on the 1 and 2 round (>30%)...
January 20, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28133806/native-like-env-trimers-as-a-platform-for-hiv-1-vaccine-design
#19
REVIEW
Rogier W Sanders, John P Moore
We describe the development and potential use of various designs of recombinant HIV-1 envelope glycoprotein trimers that mimic the structure of the virion-associated spike, which is the target for neutralizing antibodies. The goal of trimer development programs is to induce broadly neutralizing antibodies with the potential to intervene against multiple circulating HIV-1 strains. Among the topics we address are the designs of various constructs; how native-like trimers can be produced and purified; the properties of such trimers in vitro and their immunogenicity in various animals; and the immunization strategies that may lead to the eventual elicitation of broadly neutralizing antibodies...
January 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28130466/antisaccades-in-parkinson-disease-a-new-marker-of-postural-control
#20
Claire Ewenczyk, Salma Mesmoudi, Cécile Gallea, Marie-Laure Welter, Bertrand Gaymard, Adèle Demain, Lydia Yahia Cherif, Bertrand Degos, Habib Benali, Pierre Pouget, Cyril Poupon, Stéphane Lehericy, Sophie Rivaud-Péchoux, Marie Vidailhet
OBJECTIVE: To describe the relation between gaze and posture/gait control in Parkinson disease (PD) and to determine the role of the mesencephalic locomotor region (MLR) and cortex-MLR connection in saccadic behavior because this structure is a major area involved in both gait/postural control and gaze control networks. METHODS: We recruited 30 patients with PD with or without altered postural control and 25 age-matched healthy controls (HCs). We assessed gait, balance, and neuropsychological status and separately recorded gait initiation and eye movements (visually guided saccades and volitional antisaccades)...
January 27, 2017: Neurology
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