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https://www.readbyqxmd.com/read/29774640/regulatory-roles-of-flavonoids-on-inflammasome-activation-during-inflammatory-responses
#1
REVIEW
Young-Su Yi
Inflammation is an innate immune response to noxious stimuli to protect the body from pathogens and dangers. Inflammatory responses consist of two main steps: priming and triggering. In priming, inflammatory cells increase expressions of inflammatory molecules, while in triggering, inflammasomes are activated, resulting in cell death and pro-inflammatory cytokine secretion. Inflammasomes are protein complexes comprising intracellular pattern recognition receptors (PRRs) (e.g. nucleotide-binding oligomerization domain-like receptors (NLRs), absent in melanoma 2 (AIM2), and caspases-4/5/11) and pro-caspase-1 with or without a bipartite adaptor molecule ASC...
May 17, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29774028/nlrp3-inflammasome-and-caspase-1-11-pathway-orchestrate-different-outcomes-in-the-host-protection-against-trypanosoma-cruzi-acute-infection
#2
Augusto F Paroli, Patricia V Gonzalez, Cintia Díaz-Luján, Luisina I Onofrio, Alfredo Arocena, Roxana C Cano, Eugenio A Carrera-Silva, Susana Gea
Infection with protozoan parasite Trypanosoma cruzi results in activation of nucleotide-binding domain and leucine-rich repeat containing receptors (NLRs). NLR activation leads to inflammasome formation, the activation of caspase-1, and the subsequent cleavage of IL-1β and IL-18. Considering that inflammasome activation and IL-1β induction by macrophages are key players for an appropriate T cell response, we investigated the relevance of NLR pyrin domain-containing 3 (NLRP3) and caspase-1/11 to elucidate their roles in the induction of different T cell phenotypes and the relationship with parasite load and hepatic inflammation during T...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29767237/a-novel-anti%C3%A2-proliferative-pentapeptide-ilymp-isolated-from-cyclina-sinensis-protein-hydrolysate-induces-apoptosis-of-du%C3%A2-145-prostate-cancer-cells
#3
Fangmiao Yu, Yaru Zhang, Lei Ye, Yunping Tang, Guofang Ding, Xiaojun Zhang, Zuisu Yang
Prostate cancer is the main causes of cancer associated mortality in men worldwide, cancer patients often suffer serious side effects when treated with chemotherapy or radiotherapy, therefore novel drugs are in high demand to treat prostate cancer. In the present study, a pentapeptide (Ile‑Leu‑Tyr‑Met‑Pro; ILYMP) with a molecular weight of 635.71 Da was isolated from the protein hydrolysate of Cyclina sinensis via ultrafiltration and chromatographic methods, and subsequently named Cyclina sinensis pentapeptide (CSP)...
May 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29765513/20-s-protopanaxadiol-regio-selectively-targets-androgen-receptor-anticancer-effects-in-castration-resistant-prostate-tumors
#4
Mohamed Ben-Eltriki, Subrata Deb, Mohamed Hassona, Gray Meckling, Ladan Fazli, Mei Yieng Chin, Nada Lallous, Takeshi Yamazaki, William Jia, Paul S Rennie, Artem Cherkasov, Emma S Tomlinson Guns
We have explored the effects of 20(S)-protopanaxadiol (aPPD), a naturally derived ginsenoside, against androgen receptor (AR) positive castration resistant prostate cancer (CRPC) xenograft tumors and have examined its interactions with AR. In silico docking studies for aPPD binding to AR, alongside transactivation bioassays and in vivo efficacy studies were carried out in the castration-resistant C4-2 xenograft model. Immunohistochemical (IHC) and Western blot analyses followed by evaluation of AR, apoptotic, cell cycle and proliferative markers in excised tumors was performed...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29761903/the-combination-of-a-sphingosine-kinase-2-inhibitor-abc294640-and-a-bcl-2-inhibitor-abt-199-displays-synergistic-anti-myeloma-effects-in-myeloma-cells-without-a-t-11-14-translocation
#5
Pasupathi Sundaramoorthy, Cristina Gasparetto, Yubin Kang
Multiple myeloma (MM) remains an incurable disease in need of the development of novel therapeutic agents and drug combinations. ABT-199 is a specific Bcl-2 inhibitor in clinical trials for MM; however, its activity as a single agent was limited to myeloma patients with the t(11;14) translocation who acquire resistance due to co-expression of Mcl-1 and Bcl-xL. These limitations preclude its use in a broader patient population. We have recently found that a sphingosine kinase 2-specific inhibitor (ABC294640) induces apoptosis in primary human CD138+ cells and MM cell lines...
May 15, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29749500/vacquinol%C3%A2-1-induces-apoptosis-in-hepatocellular-carcinoma-cell
#6
Shu-Lan Sun, Xiaoxi Li, Nan Su, Shi Chen, Xiaoxin Gao, Guirong Zhang, Haozhe Piao
Vacquinol‑1 (Vacq), a quinolone derivative, has recently been reported to display potent antitumor effects in glioblastomas by inducing cellular massive vacuolization and cell death. However, whether Vacq induces cytotoxicities in other types of cancers, and the potential underlying mechanism, remain to be investigated. In the present study, it was revealed that Vacq suppressed cell growth and colony formation in the hepatocellular carcinoma (HCC) cell lines BEL7402 and Huh7. In addition, treatment with Vacq increased the number of early and late apoptotic cells as assessed by flow cytometry with fluorescein isothiocyanate‑conjugated Annexin V and propidium iodide double staining...
May 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29738791/altered-gene-expression-pattern-indicates-the-differential-regulation-of-the-immune-response-system-as-an-important-factor-in-cardiac-aging
#7
Babett Bartling, Katja Niemann, Rainer U Pliquett, Hendrik Treede, Andreas Simm
Numerous changes occur in the old myocardium which finally cause lower cardiac output and, therefore, circulatory dysfunction. In order to identify an age-related gene expression pattern, we analyzed left ventricular myocardium of adult (6 months) and old (24 months) mice by use of whole genome expression arrays. About 2.3% of genes expressed above the median value of all genes were differentially expressed in old hearts. Nearly all of them were upregulated. After application of defined exclusion criteria, 98 genes were selected for a more detailed analysis...
May 5, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29734526/synthesis-of-lanostane-type-triterpenoid-n-glycosides-and-their-cytotoxicity-against-human-cancer-cell-lines
#8
Motohiko Ukiya, Teppei Hayakawa, Kouta Okazaki, Maiko Hikawa, Hiroyuki Akazawa, Wei Li, Kazuo Koike, Makoto Fukatsu
Seventeen lanostane-type triterpenoid derivatives (2-18), including 11 N-glycosides (8-18), were synthesized from the natural triterpenoid, lanosterol (1), and were evaluated for their cytotoxicity against the human cancer cell lines, HL-60, A549, and MKN45, as well as the normal human lung cells, WI-38. Among them, N-β-d-2-acetamido-2-deoxyglucoside (10) showed cytotoxicity against HL-60, A549, MKN45, and WI-38 cells (IC50 0.0078-2.8 μm). However, N-β-d-galactoside (12) showed cytotoxicity against HL-60 and MKN45 cells (IC50 0...
May 7, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29728534/caspase-substrates-won-t-be-defined-by-a-four-letter-code
#9
Paul J Baker, Seth L Masters
Inflammatory cell death can be mediated by the murine caspase-1 and -11. Genetic and cell biological data point to conflicting conclusions whether these caspases cleave the same substrates or use distinct mechanisms to mediate inflammation and cell death. Peptide screening and biochemical analysis by Gonzales Ramirez et al. now suggest caspase-11 specificity may be determined outside the known substrate motif and identifies substrates cleaved preferentially by caspase-1, providing new opportunities to uniquely target inflammatory caspases...
May 4, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29727961/pyrethroid-insecticide-lambda-cyhalothrin-induces-hepatic-cytochrome-p450-enzymes-oxidative-stress-and-apoptosis-in-rats
#10
María-Aránzazu Martínez, Irma Ares, José-Luis Rodríguez, Marta Martínez, David Roura-Martínez, Victor Castellano, Bernardo Lopez-Torres, María-Rosa Martínez-Larrañaga, Arturo Anadón
This study aimed to examine in rats the effects of the Type II pyrethroid lambda-cyhalothrin on hepatic microsomal cytochrome P450 (CYP) isoform activities, oxidative stress markers, gene expression of proinflammatory, oxidative stress and apoptosis mediators, and CYP isoform gene expression and metabolism phase I enzyme PCR array analysis. Lambda-cyhalothrin, at oral doses of 1, 2, 4 and 8mg/kg bw for 6days, increased, in a dose-dependent manner, hepatic activities of ethoxyresorufin O-deethylase (CYP1A1), methoxyresorufin O-demethylase (CYP1A2), pentoxyresorufin O-depentylase (CYP2B1/2), testosterone 7α- (CYP2A1), 16β- (CYP2B1), and 6β-hydroxylase (CYP3A1/2), and lauric acid 11- and 12-hydroxylase (CYP4A1/2)...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29726649/-effects-of-xialiqi-capsules-on-the-expressions-of-pcna-and-caspase-3-in-rats-withbenign-prostatic-hyperplasia
#11
Hong-Cai Cai, Le-Bin Song, Guo-Wei Zhang, Xing-Rong Qing, Dun-Sheng Mo, Wei Liu, Xu-Xin Zhan, Yu-Feng Huang, Xue-Jun Shang
Objective: To explore the effects of Xialiqi Capsules(XLQ) on the expressions of the proliferating cell nuclear antigen (PCNA) and caspase-3 in the prostate tissue of the BPH rat model. METHODS: Fifty male SD ratswereequally randomized into groups A (sham operation control), B (BPH model control), C (high-dose XLQ), D (low-dose XLQ), and E (finasteridecontrol) andthe BPH modelswere established by subcutaneous injection of testosterone propionate at 0.5 mg per kilogram of the body weight per day for 30 days after castration...
August 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29722336/mitochondrial-autophagy-and-nlrp3-inflammasome-in-pulmonary-tissues-from-severe-combined-immunodeficient-mice-after-cardiac-arrest-and-cardiopulmonary-resuscitation
#12
Jing-Jun Lyu, Jawahar L Mehta, Yi Li, Lu Ye, Sheng-Nan Sun, Hong-Shuang Sun, Jia-Chang Li, Dong-Mei Zhang, Jie Wei
Background: The incidence of cancer, diabetes, and autoimmune diseases has been increasing. Furthermore, there are more and more patients with solid organ transplants. The survival rate of these immunocompromised individuals is extremely low when they are severely hit-on. In this study, we established cardiac arrest cardiopulmonary resuscitation (CPR) model in severe combined immunodeficient (SCID) mice, analyzed the expression and activation of mitochondrial autophagy and NLRP3 inflammasome/caspase-1, and explored mitochondrial repair and inflammatory injury in immunodeficiency individual during systemic ischemia-reperfusion injury...
May 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29715052/antiproliferative-activity-of-extracts-of-campomanesia-adamantium-cambess-o-berg-and-isolated-compound-dimethylchalcone-against-b16-f10-murine-melanoma
#13
Magalli C B Lima E Silva, Danielle Bogo, Caroline A F Alexandrino, Renata T Perdomo, Patrícia de O Figueiredo, Pamela R do Prado, Fernanda R Garcez, Monica C T Kadri, Thalita V N Ximenes, Rita de Cassia A Guimarães, Ulana C Sarmento, Maria Lígia R Macedo
Campomanesia adamantium, a native species of the Brazilian Cerrado, is characterized as a natural source of phenolic compounds and has known potential anticancer activities. This study aimed to evaluate the chemical profile of dichloromethane extracts of pulp (DEGPU) and peel (DEGPE) from the fruits of C. adamantium and to identify compounds with antiproliferative effects in vitro against melanoma cells by sulforhodamine B (SRB) assay, apoptosis induction assay, caspase-3 activation assay, nitric oxide (NO) release in coculture of B16-F10 cells and murine peritoneal macrophages...
May 1, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29709511/maternal-pomegranate-juice-attenuates-maternal-inflammation-induced-fetal-brain-injury-by-inhibition-of-apoptosis-neural-nitric-oxide-synthase-and-nf-%C3%AE%C2%BAb-in-a-rat-model
#14
Yuval Ginsberg, Nizar Khatib, Noor Saadi, Michael G Ross, Zeev Weinr, Ron Beloosesky
OBJECTIVE: Maternal inflammation is a risk factor for neonatal brain injury and future neurological deficits. Pomegranates have been shown to exhibit anti-inflammatory, anti-apoptotic and anti-oxidant activities. We hypothesized that pomegranate juice (POM) may attenuate fetal brain injury in a rat model of maternal inflammation. METHODS: Pregnant rats (24 total) were randomized for i.p. LPS (100 ug/kg) or saline at time 0 at 18 days of gestation. From day 11 of gestation, 12 dams were provided ad libitum access to drinking water, and 12 dams were provided ad libitum access to drinking water with pomegranate juice (5cc per day), resulting in 4 groups of 6 dams (SAL/SAL, POM/SAL, SAL/LPS, POM/LPS)...
April 27, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29706799/recent-advances-in-the-molecular-mechanisms-underlying-pyroptosis-in-sepsis
#15
REVIEW
Yu-Lei Gao, Jian-Hua Zhai, Yan-Fen Chai
Sepsis is recognized as a life-threatening organ dysfunctional disease that is caused by dysregulated host responses to infection. Up to now, sepsis still remains a dominant cause of multiple organ dysfunction syndrome (MODS) and death among severe condition patients. Pyroptosis, originally named after the Greek words " pyro " and " ptosis " in 2001, has been defined as a specific programmed cell death characterized by release of inflammatory cytokines. During sepsis, pyroptosis is required for defense against bacterial infection because appropriate pyroptosis can minimize tissue damage...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29699910/investigation-of-novel-pyrazole-carboxamides-as-new-apoptosis-inducers-on-neuronal-cells-in-helicoverpa-zea
#16
Yuanhang Ren, Na Yang, Ying Yue, Hong Jin, Ke Tao, Taiping Hou
Novel pyrazole carboxamides with a diarylamine-modified scaffold were modified based on the bixafen (Bayer) fungicide, which has excellent activity against Rhizoctonia solani, Rhizoctonia cerealis and Sclerotinia sclerotiorum. To discover the potential insecticidal activity of these novel pyrazole carboxamides, the present study explored their possible cytoactivity on the insect neuronal cells (RP-HzVNC-AW1) in Helicoverpa zea. The preliminary bioassays showed that some of the target compounds exhibited good cytoactivity against AW1 cells...
March 8, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29695863/lubac-is-essential-for-embryogenesis-by-preventing-cell-death-and-enabling-haematopoiesis
#17
Nieves Peltzer, Maurice Darding, Antonella Montinaro, Peter Draber, Helena Draberova, Sebastian Kupka, Eva Rieser, Amanda Fisher, Ciaran Hutchinson, Lucia Taraborrelli, Torsten Hartwig, Elodie Lafont, Tobias L Haas, Yutaka Shimizu, Charlotta Böiers, Aida Sarr, James Rickard, Silvia Alvarez-Diaz, Michael T Ashworth, Allison Beal, Tariq Enver, John Bertin, William Kaiser, Andreas Strasser, John Silke, Philippe Bouillet, Henning Walczak
The linear ubiquitin chain assembly complex (LUBAC) is required for optimal gene activation and prevention of cell death upon activation of immune receptors, including TNFR1 1 . Deficiency in the LUBAC components SHARPIN or HOIP in mice results in severe inflammation in adulthood or embryonic lethality, respectively, owing to deregulation of TNFR1-mediated cell death2-8 . In humans, deficiency in the third LUBAC component HOIL-1 causes autoimmunity and inflammatory disease, similar to HOIP deficiency, whereas HOIL-1 deficiency in mice was reported to cause no overt phenotype9-11 ...
May 2018: Nature
https://www.readbyqxmd.com/read/29694939/peracetylated-hydroxytyrosol-a-new-hydroxytyrosol-derivate-attenuates-lps-induced-inflammatory-response-in-murine-peritoneal-macrophages-via-regulation-of-non-canonical-inflammasome-nrf2-ho1-and-jak-stat-signaling-pathways
#18
Tatiana Montoya, Marina Aparicio-Soto, María Luisa Castejón, María Ángeles Rosillo, Marina Sánchez-Hidalgo, Paloma Begines, José G Fernández-Bolaños, Catalina Alarcón-de-la-Lastra
The present study was designed to investigate the anti-inflammatory effects of a new derivative of hydroxytyrosol (HTy), peracetylated hydroxytyrosol (Per-HTy), compared with its parent, HTy, on lipopolysaccharide (LPS)-stimulated murine macrophages as well as potential signaling pathways involved. In particular, we attempted to characterize the role of the inflammasome underlying Per-HTy possible anti-inflammatory effects. Isolated murine peritoneal macrophages were treated with HTy or its derivative in the presence or absence of LPS (5 μg/ml) for 18 h...
March 18, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29692000/phloroglucinol-derivatives-from-the-fruits-of-eucalyptus-globulus-and-their-cytotoxic-activities
#19
Pham Thi-Anh, Imran Shair Mohammad, Vu Van-Tuan, Hu Xiao-Long, Chaurasiya Birendra, Aftab Ulah, Guo Cui, Lv Xian-Yu, Ye Wen-Cai, Wang Hao
A new phloroglucinol derivative, named Eucalyptin B (1), along with five related known compounds (2-6), was isolated from the fruits of Eucalyptus globulus. Their structures were elucidated by means of 1D and 2D NMR spectroscopy, with the absolute configuration of 1 determined by electronic circular dichroism (ECD) calculations. All isolated compounds (1-6) were evaluated for their cytotoxic activities against lung (A549), breast (4T1), and skin (B16F10) cancer cell lines. On the basis of cytoxicity the antitumor activity of Eucalyptin B (1) was further confirmed by apoptosis assay...
April 24, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29670107/inhibition-of-cancer-progression-by-a-novel-trans-stilbene-derivative-through-disruption-of-microtubule-dynamics-driving-g2-m-arrest-and-p53-dependent-apoptosis
#20
Pravat Kumar Parida, Barun Mahata, Abhisek Santra, Sohini Chakraborty, Zhumur Ghosh, Sanghamitra Raha, Anup Kumar Misra, Kaushik Biswas, Kuladip Jana
Resveratrol, a trans-stilbene polyphenolic compound and its synthetic analogs are widely used bioactive molecules due to their remarkable chemo-preventive potential. Here, we have identified a novel synthetic trans-stilbene compound, Z-DAN-11 ((Z)-3-(3, 4-dimethoxyphenyl)-2-(3, 4, 5-trimethoxyphenyl) acrylonitrile) which shows remarkable efficacy in blocking tumor growth and progression both in vitro and in vivo. Z-DAN-11 inhibits proliferation of cancer cells in vitro through microtubule depolymerization that induced G2/M arrest and consequently leads to apoptotic cell death...
April 18, 2018: Cell Death & Disease
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