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Caspase 11

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https://www.readbyqxmd.com/read/27915469/myd88-cd79b-and-card11-gene-mutations-in-cd5-positive-diffuse-large-b-cell-lymphoma
#1
Toshifumi Takeuchi, Motoko Yamaguchi, Kyoko Kobayashi, Kana Miyazaki, Isao Tawara, Hiroshi Imai, Ryoichi Ono, Tetsuya Nosaka, Kyosuke Tanaka, Naoyuki Katayama
BACKGROUND: CD5-positive (CD5(+) ) diffuse large B-cell lymphoma (DLBCL) is characterized by frequent central nervous system recurrence and a predominant activated B-cell-like nature. Primary DLBCL in sanctuary sites (DLBCL-SS) also demonstrates these features, and >70% of patients harbor myeloid differentiation primary response 88 (MYD88) (L265P) and CD79B mutations. The objective of the current study was to elucidate a possible relationship between CD5(+) DLBCL and DLBCL-SS. METHODS: MYD88, CD79B, CD79A, and caspase recruitment domain family member 11 (CARD11) mutations were examined in samples from 40 patients with CD5(+) DLBCL...
December 4, 2016: Cancer
https://www.readbyqxmd.com/read/27882085/knockdown-of-klk11-inhibits-cell-proliferation-and-increases-oxaliplatin-sensitivity-in-human-colorectal-cancer
#2
Zongbin Xu, Pan Chi, Jie Pan, Songfei Shen, Yanwu Sun, Xiaojie Wang, Xingrong Lu
It has been reported that kallikrein 11 (KLK11) is crucially involved in the development and progression of various types of cancer. However, the molecular mechanisms that underlie the involvement of KLK11 in aberrant colorectal cancer (CRC) cell growth remain largely unclear. The aim of the present study was to investigate the role of KLK11 and the effects of KLK11 on oxaliplatin (L-OHP) chemosensitivity by knocking down KLK11 in LOVO and HCT-8 cells. Loss-of-function assays revealed KLK11 inhibition significantly inhibited growth and induced apoptosis of CRC cells in vitro...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27878233/benzoquinone-from-fusarium-pigment-inhibits-the-proliferation-of-estrogen-receptor-positive-mcf-7-cells-through-the-nf-%C3%AE%C2%BAb-pathway-via-estrogen-receptor-signaling
#3
Lixiang Zheng, Yujian Cai, Li Zhou, Ping Huang, Xiaoying Ren, Airen Zuo, Xianming Meng, Minjuan Xu, Xiangru Liao
Natural pigments are known for possessing a wide range of pharmacological and health-promoting properties. The pigments, produced by a new strain Fusarium (Fusarium sp. JN158) previously identified in our laboratory, were found to have 6 peaks (representing 6 compounds) by high-performance liquid chromatography with a diode-array detector (HPLC-DAD) separation. The 6th peak compound (compound VI) is a benzoquinone compound. In this study, we examined the effects of compound VI on the proliferation of breast cancer cells and aimed to elucidate the underlying mechamisms...
November 22, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27868407/-effect-of-dj-1-silencing-by-rna-interference-on-growth-of-xenografted-human-laryngeal-squamous-cell-carcinoma-hep-2-cells-in-nude-mice
#4
Zhisen Shen, Hongxia Deng, Dong Ye, Jian Zhang, Shijie Qiu, Qun Li, Xiang Cui
Objective: To investigate the effect of silencing DJ-1 on xenografted human laryngeal squamous cell carcinoma (LSCC) Hep-2 cells in nude mice. Methods: Xenograft model of human LSCC was established by subcutaneous transplantation of Hep-2 cells in 24 nude mice. The LSCC-bearing nude mice were randomly divided into 3 groups (n=8 in each):DJ-1 siRNA low dose group and DJ-1 siRNA high dose group were injected in tumors with 20 μg of DJ-1 siRNA or 40 μg of DJ-1 siRNA in 50 μL, respectively; control group was injected with 5% glucose solution in 50 μL, twice a week for 3 weeks...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/27865411/low-levels-of-apoptotic-like-changes-in-fresh-and-cryopreserved-feline-spermatozoa-collected-from-the-urethra-and-epididymis
#5
Sylwia Prochowska, Wojciech Niżański, Agnieszka Partyka
The aim of this study was to examine apoptotic markers in fresh and frozen-thawed feline spermatozoa collected via urethral catheterization and epididymal slicing. Caspase activation, DNA fragmentation, and phosphatidylserine externalization were evaluated using flow cytometry in sperm cells from both sources before and after cryopreservation. The study revealed no differences between urethral and epididymal spermatozoa, both in fresh and frozen-thawed samples. The level of apoptotic changes in sperm cells in fresh feline semen was low: 0...
January 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/27857884/tumor-selective-cytotoxicity-of-a-novel-pentadiene-analogue-on-human-leukemia-lymphoma-cells
#6
Yahaira Santiago-Vázquez, Umashankar Das, Armando Varela-Ramirez, Sarah T Baca, Yoshira Ayala-Marin, Carolina Lema, Swagatika Das, Alaa Baryyan, Jonathan R Dimmock, Renato J Aguilera
BACKGROUND: A novel series of structurally divergent 1,5-diaryl-3-oxo-1,4-pentadiene analogues 1-10 displayed marked cytotoxic potencies towards a number of human leukemia/lymphoma cells. OBJECTIVE: To identify novel selective cytotoxic compounds that induce apoptosis. METHODS: The Differential Nuclear Staining (DNS) screening protocol was utilized to measure the cytotoxicity of all experimental dienones on several cancerous cells. Additionally, the selective cytotoxicity index was calculated by comparing the dienone's cytotoxicity between leukemia/lymphoma cells vs...
2016: Clinical Cancer Drugs
https://www.readbyqxmd.com/read/27834956/a-bak-dependent-mitochondrial-amplification-step-contributes-to-smac-mimetic-glucocorticoid-induced-necroptosis
#7
Katharina Rohde, Lara Kleinesudeik, Stefanie Roesler, Oliver Löwe, Juliana Heidler, Katrin Schröder, Ilka Wittig, Stefan Dröse, Simone Fulda
Necroptosis is a form of programmed cell death that critically depends on RIP3 and MLKL. However, the contribution of mitochondria to necroptosis is still poorly understood. In the present study, we discovered that mitochondrial perturbations play a critical role in Smac mimetic/Dexamethasone (Dexa)-induced necroptosis independently of death receptor ligands. We demonstrate that the Smac mimetic BV6 and Dexa cooperate to trigger necroptotic cell death in acute lymphoblastic leukemia (ALL) cells that are deficient in caspase activation due to absent caspase-8 expression or pharmacological inhibition by the caspase inhibitor zVAD...
November 11, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27834952/double-stranded-rna-promotes-ctl-independent-tumor-cytolysis-mediated-by-cd11b-ly6g-intratumor-myeloid-cells-through-the-ticam-1-signaling-pathway
#8
Hiroaki Shime, Misako Matsumoto, Tsukasa Seya
PolyI:C, a synthetic double-stranded RNA analog, acts as an immune-enhancing adjuvant that regresses tumors in cytotoxic T lymphocyte (CTL)-dependent and CTL-independent manner, the latter of which remains largely unknown. Tumors contain CD11b(+)Ly6G(+) cells, known as granulocytic myeloid-derived suppressor cells (G-MDSCs) or tumor-associated neutrophils (TANs) that play a critical role in tumor progression and development. Here, we demonstrate that CD11b(+)Ly6G(+) cells respond to polyI:C and exhibit tumoricidal activity in an EL4 tumor implant model...
November 11, 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27819681/ripk1-counteracts-zbp1-mediated-necroptosis-to-inhibit-inflammation
#9
Juan Lin, Snehlata Kumari, Chun Kim, Trieu-My Van, Laurens Wachsmuth, Apostolos Polykratis, Manolis Pasparakis
Receptor-interacting protein kinase 1 (RIPK1) regulates cell death and inflammation through kinase-dependent and -independent functions. RIPK1 kinase activity induces caspase-8-dependent apoptosis and RIPK3 and mixed lineage kinase like (MLKL)-dependent necroptosis. In addition, RIPK1 inhibits apoptosis and necroptosis through kinase-independent functions, which are important for late embryonic development and the prevention of inflammation in epithelial barriers. The mechanism by which RIPK1 counteracts RIPK3-MLKL-mediated necroptosis has remained unknown...
December 1, 2016: Nature
https://www.readbyqxmd.com/read/27816647/synthesis-characterization-and-anticancer-effect-of-the-ruthenium-ii-polypyridyl-complexes-on-hepg2-cells
#10
Dan Wan, Shang-Hai Lai, Hui-Hui Yang, Bing Tang, Cheng Zhang, Hui Yin, Chuan-Chuan Zeng, Yun-Jun Liu
As one of the major cell regulated center, mitochondria are closely associated with cell proliferation, apoptosis of tumor cell. In this work, four new ruthenium (II) polypyridyl complexes [Ru(bpy)2(FTTP)](ClO4)2 (1) (FTTP=11-(3-fluoro-naphthalen-2-yloxy)-4,5,9,14-tetraaza-benzo[b]triphenylene, bpy=2,2'-bipyridine), [Ru(phen)2(FTTP)](ClO4)2 (2) (phen=1,10-phenanthroline), [Ru(bpy)2(PTTP)](ClO4)2 (3) (PTTP=2-phenoxy-1,4,8,9-tetraazatriphenylene) and [Ru(phen)2(PTTP)](ClO4)2 (4) were synthesized and characterized by elemental analysis, ESI-MS, (1)H NMR and (13)C NMR...
October 31, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27814949/neo-tanshinlactone-d-ring-modified-novel-analogues-induce-apoptosis-in-human-breast-cancer-cell-via-dna-damage
#11
Biswadip Banerji, Sunil Kumar Killi, Atul Katarkar, Satadru Chatterjee, Yellaiah Tangella, Chandraday Prodhan, Keya Chaudhuri
Neo-tanshinlactone (NTL) a natural product is known for its specificity and selectivity towards the breast cancer cells. By NTL D-ring modification approach, 13 new analogues were synthesized (1A-1M). Among them 1J showed the best anticancer activity in MCF-7 (ER+, PR+/-, HER2-), SKBR3 (ER-, PR-, HER2+) and MDA-MB-231 (ER-, PR-, HER2-) cells lines with IC50 value 11.98nM, 23.71nM, and 62.91nM respectively. 1J showed minor grove binding interaction with DNA at AT-rich region and induced DNA double strand breaks (DDSBs)...
October 21, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27808091/growth-inhibition-of-cytosolic-salmonella-by-caspase-1-and-caspase-11-precedes-host-cell-death
#12
Teresa L M Thurston, Sophie A Matthews, Elliott Jennings, Eric Alix, Feng Shao, Avinash R Shenoy, Mark A Birrell, David W Holden
Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β. In addition, mouse caspase-11 (represented in humans by its orthologs, caspase-4 and caspase-5) detects cytosolic bacterial LPS directly. Activation of caspase-1 and caspase-11 initiates pyroptotic host cell death that releases potentially harmful bacteria from the nutrient-rich host cell cytosol into the extracellular environment...
November 3, 2016: Nature Communications
https://www.readbyqxmd.com/read/27801783/cytotoxicity-of-11-epi-sinulariolide-acetate-isolated-from-cultured-soft-corals-on-ha22t-cells-through-the-endoplasmic-reticulum-stress-pathway-and-mitochondrial-dysfunction
#13
Jen-Jie Lin, Robert Y L Wang, Jiing-Chuan Chen, Chien-Chih Chiu, Ming-Hui Liao, Yu-Jen Wu
Natural compounds from soft corals have been increasingly used for their antitumor therapeutic properties. This study examined 11-epi-sinulariolide acetate (11-epi-SA), an active compound isolated from the cultured soft coral Sinularia flexibilis, to determine its potential antitumor effect on four hepatocellular carcinoma cell lines. Cell viability was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and the results demonstrated that 11-epi-SA treatment showed more cytotoxic effect toward HA22T cells...
October 27, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27777308/molecular-determinants-of-scaffold-induced-linear-ubiquitinylation-of-b-cell-lymphoma-leukemia-10-bcl10-during-t-cell-receptor-and-oncogenic-caspase-recruitment-domain-containing-protein-11-card11-signaling
#14
Yong-Kang Yang, Chao Yang, Waipan Chan, Zhaoquan Wang, Katelynn E Deibel, Joel L Pomerantz
The activation of NF-κB downstream of T Cell Receptor (TCR) engagement is a key signaling step required for normal lymphocyte function during the adaptive immune response. During TCR signaling, the adaptor protein Bcl10 is inducibly recruited to the CARD11 scaffold protein as part of a multicomponent complex that induces IKK kinase activity and NF-κB activation. Here we show that a consequence of this recruitment is the TCR-induced conjugation of Bcl10 with linear-linked polyubiquitin chains, to generate the signaling intermediate Lin(Ub)n-Bcl10, which is required for the association of Bcl10 with the NEMO subunit of the IKK complex...
October 24, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27770735/analogue-based-drug-design-synthesis-molecular-docking-and-anticancer-evaluation-of-novel-chromene-sulfonamide-hybrids-as-aromatase-inhibitors-and-apoptosis-enhancers
#15
Mostafa M Ghorab, Mansour S Alsaid, Ghada H Al-Ansary, Ghada A Abdel-Latif, Dalal A Abou El Ella
Twenty novel chromene derivatives carrying different sulfonamide moieties (3-22) were designed and synthesized. All the newly prepared compounds were evaluated for their in vitro anticancer activity against breast cancer cell line (T47D). Most of the synthesized compounds showed good to moderate activity (IC50 = 8.8-108.9 μM), where compound 16 (IC50 = 8.8 μM) exhibited higher activity compared to doxorubicin (IC50 = 9.8 μM). In order to determine the mechanism of the anticancer activity in T47D cells, the effect of the most potent compounds (5-8, 11-14, and 16-18) on the aromatase activity was tested...
October 13, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27748367/a-novel-resveratrol-based-tubulin-inhibitor-induces-mitotic-arrest-and-activates-apoptosis-in-cancer-cells
#16
Elizabeth Thomas, Vidya Gopalakrishnan, Mahesh Hegde, Sujeet Kumar, Subhas S Karki, Sathees C Raghavan, Bibha Choudhary
Resveratrol is one of the most widely studied bioactive plant polyphenols which possesses anticancer properties. Previously we have reported synthesis, characterization and identification of a novel resveratrol analog, SS28. In the present study, we show that SS28 induced cytotoxicity in several cancer cell lines ex vivo with an IC50 value of 3-5 μM. Mechanistic evaluation of effect of SS28 in non-small cell lung cancer cell line (A549) and T-cell leukemic cell line (CEM) showed that it inhibited Tubulin polymerization during cell division to cause cell cycle arrest at G2/M phase of the cell cycle at 12-18 h time period...
October 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27741210/protective-effect-of-selenium-against-cisplatin-induced-ototoxicity-in-an-experimental-design
#17
Sedat Doğan, Hasmet Yazici, Esin Yalçinkaya, Halil Ibrahim Erdoğdu, Sibel Alicura Tokgöz, Furkan Sarici, Mehmet Namuslu, Yasin Sarikaya
Cisplatin is an effective chemotherapeutic agent in the treatment of several types of malignant solid tumors but its clinical use is associated with ototoxicity. In the present study, we investigated the effect of selenium administration on lipid peroxidation (malondialdehyde [MDA]) and cisplatin-induced ototoxicity in rats. Healthy wistar albino rats (n = 21) were randomly divided into 3 groups: control (C), cisplatin (Cis), cisplatin and selenium (Cis+Se). Cisplatin was administered for 3 days to Cis and Cis+Se groups...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27723786/genetic-polymorphisms-in-the-apoptosis-associated-gene-casp3-and-the-risk-of-lung-cancer-in-chinese-population
#18
Jia Lin, Yanyan Zhang, Hongge Wang, Jiang Chang, Lixuan Wei, Lei Cao, Zhi Zhang, Xuemei Zhang
Caspase-3 (CASP3) plays a central role in executing cell apoptosis and thus in carcinogenesis. We previously investigated the relationship between functional polymorphisms in CAPS3 829 A>C and 20541 C>T and risk of esophageal squamous cell carcinoma. However little is known about the role of CASP3 variants in susceptibility to lung cancer. To figure out the contribution of CASP3 polymorphisms to lung cancer risk, genotypes of 1000 lung cancer patients and 1000 controls were conducted by RFLP-PCR (restriction fragment length polymorphism PCR)...
2016: PloS One
https://www.readbyqxmd.com/read/27709293/expression-of-fas-fasl-caspase-8-and-other-factors-of-the-extrinsic-apoptotic-pathway-during-the-onset-of-interdigital-tissue-elimination
#19
E Budisova Svandova, B Vesela, H Lesot, A Poliard, E Matalova
Elimination of the interdigital web is considered to be the classical model for assessing apoptosis. So far, most of the molecules described in the process have been connected to the intrinsic (mitochondrial) pathway. The extrinsic (receptor mediated) apoptotic pathway has been rather neglected, although it is important in development, immunomodulation and cancer therapy. This work aimed to investigate factors of the extrinsic apoptotic machinery during interdigital regression with a focus on three crucial initiators: Fas, Fas ligand and caspase-8...
October 5, 2016: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/27697835/complement-pathway-amplifies-caspase-11-dependent-cell-death-and-endotoxin-induced-sepsis-severity
#20
Brooke A Napier, Sky W Brubaker, Timothy E Sweeney, Patrick Monette, Greggory H Rothmeier, Nina A Gertsvolf, Andreas Puschnik, Jan E Carette, Purvesh Khatri, Denise M Monack
Cell death and release of proinflammatory mediators contribute to mortality during sepsis. Specifically, caspase-11-dependent cell death contributes to pathology and decreases in survival time in sepsis models. Priming of the host cell, through TLR4 and interferon receptors, induces caspase-11 expression, and cytosolic LPS directly stimulates caspase-11 activation, promoting the release of proinflammatory cytokines through pyroptosis and caspase-1 activation. Using a CRISPR-Cas9-mediated genome-wide screen, we identified novel mediators of caspase-11-dependent cell death...
October 17, 2016: Journal of Experimental Medicine
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