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Douglas Altman

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https://www.readbyqxmd.com/read/28632286/consort-extension-for-chinese-herbal-medicine-formulas-2017-recommendations-explanation-and-elaboration-traditional-chinese-version
#1
Chung-Wah Cheng, Tai-Xiang Wu, Hong-Cai Shang, You-Ping Li, Douglas G Altman, David Moher, Zhao-Xiang Bian
Editors' Note: This article is the traditional Chinese version of the CONSORT Extension for Chinese Herbal Medicine Formulas 2017: Recommendations, Explanation, and Elaboration. (Cheng C, Wu T, Shang H, Li, Y, Altman D, Moher D; CONSORT-CHM Formulas 2017 Group. CONSORT Extension for Chinese Herbal Medicine Formulas 2017: Recommendations, Explanation, and Elaboration. Ann Intern Med. 2017. [Epub 27 June 2017]. doi:10.7326/M16-2977).
June 27, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28632282/consort-extension-for-chinese-herbal-medicine-formulas-2017-recommendations-explanation-and-elaboration
#2
Chung-Wah Cheng, Tai-Xiang Wu, Hong-Cai Shang, You-Ping Li, Douglas G Altman, David Moher, Zhao-Xiang Bian
Chinese herbal medicine (CHM) formulas are the major components of traditional Chinese medicine (TCM) interventions. The general reporting quality of randomized controlled trials (RCTs) of CHM formulas is disappointing, although CONSORT (Consolidated Standards of Reporting Trials) Statement extensions for herbal medicinal interventions and acupuncture interventions are available. A group of TCM clinical experts, methodologists, epidemiologists, and editors has developed this CONSORT Extension for CHM Formulas (CONSORT-CHM Formulas 2017) through a comprehensive process, including publication of the draft version, solicitation of comments, revision, and finalization...
June 27, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28632281/consort-extension-for-chinese-herbal-medicine-formulas-2017-recommendations-explanation-and-elaboration-simplified-chinese-version
#3
Chung-Wah Cheng, Tai-Xiang Wu, Hong-Cai Shang, You-Ping Li, Douglas G Altman, David Moher, Zhao-Xiang Bian
Editors' Note: This article is the simplified Chinese version of the CONSORT Extension for Chinese Herbal Medicine Formulas 2017: Recommendations, Explanation, and Elaboration. (Cheng C, Wu T, Shang H, Li, Y, Altman D, Moher D; CONSORT-CHM Formulas 2017 Group. CONSORT Extension for Chinese Herbal Medicine Formulas 2017: Recommendations, Explanation, and Elaboration. Ann Intern Med. 2017. [Epub 27 June 2017]. doi:10.7326/M16-2977).
June 27, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28630973/consort-statement-for-randomized-trials-of-nonpharmacologic-treatments-a-2017-update-and-a-consort-extension-for-nonpharmacologic-trial-abstracts
#4
Isabelle Boutron, Douglas G Altman, David Moher, Kenneth F Schulz, Philippe Ravaud
Incomplete and inadequate reporting is an avoidable waste that reduces the usefulness of research. The CONSORT (Consolidated Standards of Reporting Trials) Statement is an evidence-based reporting guideline that aims to improve research transparency and reduce waste. In 2008, the CONSORT Group developed an extension to the original statement that addressed methodological issues specific to trials of nonpharmacologic treatments (NPTs), such as surgery, rehabilitation, or psychotherapy. This article describes an update of that extension and presents an extension for reporting abstracts of NPT trials...
June 20, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28629396/identifying-approaches-for-assessing-methodological-and-reporting-quality-of-systematic-reviews-a-descriptive-study
#5
Kusala Pussegoda, Lucy Turner, Chantelle Garritty, Alain Mayhew, Becky Skidmore, Adrienne Stevens, Isabelle Boutron, Rafael Sarkis-Onofre, Lise M Bjerre, Asbjørn Hróbjartsson, Douglas G Altman, David Moher
BACKGROUND: The methodological quality and completeness of reporting of the systematic reviews (SRs) is fundamental to optimal implementation of evidence-based health care and the reduction of research waste. Methods exist to appraise SRs yet little is known about how they are used in SRs or where there are potential gaps in research best-practice guidance materials. The aims of this study are to identify reports assessing the methodological quality (MQ) and/or reporting quality (RQ) of a cohort of SRs and to assess their number, general characteristics, and approaches to 'quality' assessment over time...
June 19, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28614415/did-the-reporting-of-prognostic-studies-of-tumour-markers-improve-since-the-introduction-of-remark-guideline-a-comparison-of-reporting-in-published-articles
#6
Peggy Sekula, Susan Mallett, Douglas G Altman, Willi Sauerbrei
Although biomarkers are perceived as highly relevant for future clinical practice, few biomarkers reach clinical utility for several reasons. Among them, poor reporting of studies is one of the major problems. To aid improvement, reporting guidelines like REMARK for tumour marker prognostic (TMP) studies were introduced several years ago. The aims of this project were to assess whether reporting quality of TMP-studies improved in comparison to a previously conducted study assessing reporting quality of TMP-studies (PRE-study) and to assess whether articles citing REMARK (citing group) are better reported, in comparison to articles not citing REMARK (not-citing group)...
2017: PloS One
https://www.readbyqxmd.com/read/28596181/evolution-of-poor-reporting-and-inadequate-methods-over-time-in-20%C3%A2-920-randomised-controlled-trials-included-in-cochrane-reviews-research-on-research-study
#7
Agnes Dechartres, Ludovic Trinquart, Ignacio Atal, David Moher, Kay Dickersin, Isabelle Boutron, Elodie Perrodeau, Douglas G Altman, Philippe Ravaud
Objective To examine how poor reporting and inadequate methods for key methodological features in randomised controlled trials (RCTs) have changed over the past three decades.Design Mapping of trials included in Cochrane reviews.Data sources Data from RCTs included in all Cochrane reviews published between March 2011 and September 2014 reporting an evaluation of the Cochrane risk of bias items: sequence generation, allocation concealment, blinding, and incomplete outcome data.Data extraction For each RCT, we extracted consensus on risk of bias made by the review authors and identified the primary reference to extract publication year and journal...
June 8, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28588121/assessing-agreement-between-methods-of-measurement
#8
Douglas G Altman, J Martin Bland
No abstract text is available yet for this article.
June 6, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28571655/a-novel-approach-to-predict-24-hour-energy-expenditure-based-on-hematologic-volumes-development-and-validation-of-models-comparable-to-mifflin-st-jeor-and-body-composition-models
#9
Douglas C Chang, Paolo Piaggi, Jonathan Krakoff
BACKGROUND: Accurate prediction of 24-hour energy expenditure (24EE) relies on knowing body composition, in particular fat-free mass (FFM), the largest determinant of 24EE. FFM is closely correlated with hematologic volumes: blood volume (BV), red cell mass (RCM), and plasma volume (PV). However, it is unknown whether predicted hematologic volumes, based on easily collected variables, can improve 24EE prediction. OBJECTIVE: The aim was to develop and validate equations to predict 24EE based on predicted BV, RCM, and PV and to compare the accuracy and agreement with models developed from FFM and with the Mifflin-St Jeor equation, which is recommended for clinical use by the Academy of Nutrition and Dietetics...
May 29, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28570492/estimation-of-peak-muscle-power-from-a-countermovement-vertical-jump-in-children-and-adolescents
#10
Alejandro Gomez-Bruton, Leigh Gabel, Lindsay Nettlefold, Heather Macdonald, Douglas Race, Heather McKay
Several equations to predict muscle power (MP) from vertical jump height (VJH) have been developed in adults. However, few have been derived in children. We therefore aimed to: 1) evaluate the validity of existing MP estimation equations from a vertical countermovement jump (CMJ) in children and adolescents, and 2) develop and validate a new MP estimation equation for use in children and adolescents. We measured peak MP (Watts) and VJH (cm) during a CMJ using a force platform in 249 children and adolescents (9-17 years; 119 boys)...
May 30, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28566338/associations-between-adding-a-radial-artery-graft-to-single-and-bilateral-internal-thoracic-artery-grafts-and-outcomes-insights-from-the-arterial-revascularization-trial
#11
David P Taggart, Douglas G Altman, Marcus D Flather, Stephen Gerry, Alastair M Gray, Belinda Lees, Umberto Benedetto
Background -Whether the use of the radial artery (RA) can improve clinical outcomes in coronary artery bypass graft (CABG) surgery remains unclear. The Arterial Revascularization Trial (ART) was designed to compare survival after bilateral internal thoracic artery (BITA) over single left internal thoracic artery (SITA). In the ART, a large proportion of patients (~20%) also received a RA graft instead of a saphenous vein graft (SVG). We aimed to investigate the associations between using the RA instead of SVG to supplement SITA or BITA grafts and outcomes by performing a post-hoc analysis of the ART...
May 31, 2017: Circulation
https://www.readbyqxmd.com/read/28529185/care-2013-explanations-and-elaborations-reporting-guidelines-for-case-reports
#12
David S Riley, Melissa S Barber, Gunver S Kienle, Jeffry Aronson, Tido von Schoen-Angerer, Peter Tugwell, Helmut Kiene, Mark Helfand, Douglas G Altman, Harold Sox, Paul G Werthmann, David Moher, Richard A Rison, Larissa Shamseer, Christian A Koch, Gordon H Sun, Patrick Hanaway, Cleveland Clinic, Nancy L Sudak, Marietta Kaszkin-Bettag, Joel J Gagnier
Well-written and transparent case reports (1) reveal early signals of potential benefits, harms, and information on the use of resources; (2) provide information for clinical research and clinical practice guidelines (CPGs), and (3) inform medical education. High-quality case reports are more likely when authors follow reporting guidelines. During 2011-2012 a group of clinicians, researchers, and journal editors developed recommendations for the accurate reporting of information in case reports that resulted in the CARE (CAse REport) Statement and Checklist...
May 18, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28503693/exploiting-the-unusual-effects-of-fluorine-in-methodology
#13
Douglas L Orsi, Ryan A Altman
Fluorination of organic molecules significantly impacts the basic physicochemical properties of small and large biologically active molecules, agrichemicals, and materials. Thus, the development of synthetic reactions to access these substructures is important for many applied fields of chemistry. However, these fluorine-induced perturbations of chemical properties can inhibit standard chemical transformations, which provides unique challenges for synthetic organic chemists. In addition, the physicochemical properties imparted by fluorinated substituents can enable distinct reactivity patterns relative to non-fluorinated substrates, thus making synthetic organofluorine chemistry a fertile ground for developing new, exciting transformations...
May 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28467883/heart-rate-heart-rhythm-and-prognostic-benefits-of-beta-blockers-in-heart-failure-individual-patient-data-meta-analysis
#14
Dipak Kotecha, Marcus D Flather, Douglas G Altman, Jane Holmes, Giuseppe Rosano, John Wikstrand, Milton Packer, Andrew J S Coats, Luis Manzano, Michael Böhm, Dirk J van Veldhuisen, Bert Andersson, Hans Wedel, Thomas G von Lueder, Alan S Rigby, Åke Hjalmarson, John Kjekshus, John G F Cleland
BACKGROUND: The relationship between mortality and heart rate remains unclear for patients with heart failure and reduced ejection fraction (HFrEF) in either sinus rhythm or atrial fibrillation (AF). OBJECTIVE: To investigate the prognostic importance of heart rate in HFrEF in randomized controlled trials (RCTs) comparing beta-blockers and placebo. METHODS: The Beta-blockers in Heart Failure Collaborative Group performed a meta-analysis of harmonized individual-patient data from eleven double-blind RCTs...
April 5, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28464134/characteristics-and-dissemination-of-phase-1-trials-approved-by-a-uk-regional-office-in-2012
#15
Ayodele Odutayo, Bethan Copsey, Susan Dutton, Jonathan Cook, Sally Hopewell, Douglas G Altman
No abstract text is available yet for this article.
May 2, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28450552/one-year-costs-of-bilateral-or-single-internal-mammary-grafts-in-the-arterial-revascularisation-trial
#16
Alastair M Gray, Jacqueline Murphy, Douglas G Altman, Umberto Benedetto, Helen Campbell, Marcus Flather, Stephen Gerry, Belinda Lees, David P Taggart
OBJECTIVE: Coronary artery bypass grafting (CABG) using bilateral internal mammary arteries (BIMA) may improve survival over CABG using single internal mammary arteries (SIMA), but may be surgically more complex (and therefore costly) and associated with impaired sternal wound healing. We report, for the first time, a detailed comparison of healthcare resource use and costs over 12 months, as part of the Arterial Revascularisation (ART) Trial. METHODS: 3102 patients in 28 hospitals in seven countries were randomised to CABG surgery using BIMA (n=1548) or SIMA (n=1554)...
April 27, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28445454/body-composition-at-birth-and-its-relationship-with-neonatal-anthropometric-ratios-the-newborn-body-composition-study-of-the-intergrowth-21st-project
#17
José Villar, Fabien A Puglia, Tanis R Fenton, L Cheikh Ismail, Eleonora Staines-Urias, Francesca Giuliani, Eric O Ohuma, Cesar G Victora, Peter Sullivan, Fernando C Barros, Ann Lambert, Aris T Papageorghiou, Roseline Ochieng, Yasmin A Jaffer, Douglas G Altman, Alison J Noble, Michael G Gravett, Manorama Purwar, Ruyan Pang, Ricardo Uauy, Stephen H Kennedy, Zulfiqar A Bhutta
BACKGROUND: We aimed to describe newborn body composition and identify which anthropometric ratio (weight/length; BMI; or ponderal index, PI) best predicts fat mass (FM) and fat-free mass (FFM). METHODS: Air-displacement plethysmography (PEA POD) was used to estimate FM, FFM and body fat percentage (BF%). Associations between FFM, FM and BF% and weight/length, BMI and PI were evaluated in 1,019 newborns using multivariate regression analysis. Charts for FM, FFM and BF% were generated using a prescriptive sub-sample (n=247)...
April 26, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28387790/impact-of-dual-antiplatelet-therapy-after-coronary-artery-bypass-surgery-on-1-year-outcomes-in-the-arterial-revascularization-trial%C3%A2
#18
Umberto Benedetto, Douglas G Altman, Stephen Gerry, Alastair Gray, Belinda Lees, Marcus Flather, David P Taggart
OBJECTIVES: There is still little evidence to boldport routine dual antiplatelet therapy (DAPT) with P 2 Y 12 antagonists following coronary artery bypass grafting (CABG). The Arterial Revascularization Trial (ART) was designed to compare 10-year survival after bilateral versus single internal thoracic artery grafting. We aimed to get insights into the effect of DAPT (with clopidogrel) following CABG on 1-year outcomes by performing a post hoc ART analysis. METHODS: Among patients enrolled in the ART ( n  = 3102), 609 (21%) and 2308 (79%) were discharged on DAPT or aspirin alone, respectively...
April 6, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28332397/base-catalysis-enables-access-to-%C3%AE-%C3%AE-difluoroalkylthioethers
#19
Douglas L Orsi, Brandon J Easley, Ashley M Lick, Ryan A Altman
A nucleophilic addition reaction of aryl thiols to readily available β,β-difluorostyrenes provides α,α-difluoroalkylthioethers. The reaction proceeds through an unstable anionic intermediate, prone to eliminate fluoride and generate α-fluorovinylthioethers. However, the use of base catalysis overcomes the facile β-fluoride elimination, generating α,α-difluoroalkylthioethers in excellent yields and selectivities.
April 7, 2017: Organic Letters
https://www.readbyqxmd.com/read/28292744/association-between-trial-registration-and-positive-study-findings-cross-sectional-study-epidemiological-study-of-randomized-trials-esort
#20
Ayodele Odutayo, Connor A Emdin, Allan J Hsiao, Mubeen Shakir, Bethan Copsey, Susan Dutton, Virginia Chiocchia, Michael Schlussel, Peter Dutton, Corran Roberts, Douglas G Altman, Sally Hopewell
Objective To assess whether randomised controlled trials (RCTs) that were registered were less likely to report positive study findings compared with RCTs that were not registered and whether the association varied by funding source.Design Cross sectional study.Study sample All primary RCTs published in December 2012 and indexed in PubMed by November 2013. Trial registration was determined based on the report of a trial registration number in published RCTs or the identification of the trial in a search of trial registries...
March 14, 2017: BMJ: British Medical Journal
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