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Douglas Altman

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https://www.readbyqxmd.com/read/28503693/exploiting-the-unusual-effects-of-fluorine-in-methodology
#1
Douglas L Orsi, Ryan A Altman
Fluorination of organic molecules significantly impacts the basic physicochemical properties of small and large biologically active molecules, agrichemicals, and materials. Thus, the development of synthetic reactions to access these substructures is important for many applied fields of chemistry. However, these fluorine-induced perturbations of chemical properties can inhibit standard chemical transformations, which provides unique challenges for synthetic organic chemists. In addition, the physicochemical properties imparted by fluorinated substituents can enable distinct reactivity patterns relative to non-fluorinated substrates, thus making synthetic organofluorine chemistry a fertile ground for developing new, exciting transformations...
May 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28467883/heart-rate-heart-rhythm-and-prognostic-benefits-of-beta-blockers-in-heart-failure-individual-patient-data-meta-analysis
#2
Dipak Kotecha, Marcus D Flather, Douglas G Altman, Jane Holmes, Giuseppe Rosano, John Wikstrand, Milton Packer, Andrew J S Coats, Luis Manzano, Michael Böhm, Dirk J van Veldhuisen, Bert Andersson, Hans Wedel, Thomas G von Lueder, Alan S Rigby, Åke Hjalmarson, John Kjekshus, John G F Cleland
BACKGROUND: The relationship between mortality and heart rate remains unclear for patients with heart failure and reduced ejection fraction (HFrEF) in either sinus rhythm or atrial fibrillation (AF). OBJECTIVE: To investigate the prognostic importance of heart rate in HFrEF in randomized controlled trials (RCTs) comparing beta-blockers and placebo. METHODS: The Beta-blockers in Heart Failure Collaborative Group performed a meta-analysis of harmonized individual-patient data from eleven double-blind RCTs...
April 5, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28464134/characteristics-and-dissemination-of-phase-1-trials-approved-by-a-uk-regional-office-in-2012
#3
Ayodele Odutayo, Bethan Copsey, Susan Dutton, Jonathan Cook, Sally Hopewell, Douglas G Altman
No abstract text is available yet for this article.
May 2, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28450552/one-year-costs-of-bilateral-or-single-internal-mammary-grafts-in-the-arterial-revascularisation-trial
#4
Alastair M Gray, Jacqueline Murphy, Douglas G Altman, Umberto Benedetto, Helen Campbell, Marcus Flather, Stephen Gerry, Belinda Lees, David P Taggart
OBJECTIVE: Coronary artery bypass grafting (CABG) using bilateral internal mammary arteries (BIMA) may improve survival over CABG using single internal mammary arteries (SIMA), but may be surgically more complex (and therefore costly) and associated with impaired sternal wound healing. We report, for the first time, a detailed comparison of healthcare resource use and costs over 12 months, as part of the Arterial Revascularisation (ART) Trial. METHODS: 3102 patients in 28 hospitals in seven countries were randomised to CABG surgery using BIMA (n=1548) or SIMA (n=1554)...
April 27, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28445454/body-composition-at-birth-and-its-relationship-with-neonatal-anthropometric-ratios-the-newborn-body-composition-study-of-the-intergrowth-21st-project
#5
José Villar, Fabien A Puglia, Tanis R Fenton, L Cheikh Ismail, Eleonora Staines-Urias, Francesca Giuliani, Eric O Ohuma, Cesar G Victora, Peter Sullivan, Fernando C Barros, Ann Lambert, Aris T Papageorghiou, Roseline Ochieng, Yasmin A Jaffer, Douglas G Altman, Alison J Noble, Michael G Gravett, Manorama Purwar, Ruyan Pang, Ricardo Uauy, Stephen H Kennedy, Zulfiqar A Bhutta
BACKGROUND: We aimed to describe newborn body composition and identify which anthropometric ratio (weight/length; BMI; or ponderal index, PI) best predicts fat mass (FM) and fat-free mass (FFM). METHODS: Air-displacement plethysmography (PEA POD) was used to estimate FM, FFM and body fat percentage (BF%). Associations between FFM, FM and BF% and weight/length, BMI and PI were evaluated in 1,019 newborns using multivariate regression analysis. Charts for FM, FFM and BF% were generated using a prescriptive sub-sample (n=247)...
April 26, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28387790/impact-of-dual-antiplatelet-therapy-after-coronary-artery-bypass-surgery-on-1-year-outcomes-in-the-arterial-revascularization-trial%C3%A2
#6
Umberto Benedetto, Douglas G Altman, Stephen Gerry, Alastair Gray, Belinda Lees, Marcus Flather, David P Taggart
OBJECTIVES: There is still little evidence to boldport routine dual antiplatelet therapy (DAPT) with P 2 Y 12 antagonists following coronary artery bypass grafting (CABG). The Arterial Revascularization Trial (ART) was designed to compare 10-year survival after bilateral versus single internal thoracic artery grafting. We aimed to get insights into the effect of DAPT (with clopidogrel) following CABG on 1-year outcomes by performing a post hoc ART analysis. METHODS: Among patients enrolled in the ART ( n  = 3102), 609 (21%) and 2308 (79%) were discharged on DAPT or aspirin alone, respectively...
April 6, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28332397/base-catalysis-enables-access-to-%C3%AE-%C3%AE-difluoroalkylthioethers
#7
Douglas L Orsi, Brandon J Easley, Ashley M Lick, Ryan A Altman
A nucleophilic addition reaction of aryl thiols to readily available β,β-difluorostyrenes provides α,α-difluoroalkylthioethers. The reaction proceeds through an unstable anionic intermediate, prone to eliminate fluoride and generate α-fluorovinylthioethers. However, the use of base catalysis overcomes the facile β-fluoride elimination, generating α,α-difluoroalkylthioethers in excellent yields and selectivities.
April 7, 2017: Organic Letters
https://www.readbyqxmd.com/read/28292744/association-between-trial-registration-and-positive-study-findings-cross-sectional-study-epidemiological-study-of-randomized-trials-esort
#8
Ayodele Odutayo, Connor A Emdin, Allan J Hsiao, Mubeen Shakir, Bethan Copsey, Susan Dutton, Virginia Chiocchia, Michael Schlussel, Peter Dutton, Corran Roberts, Douglas G Altman, Sally Hopewell
Objective To assess whether randomised controlled trials (RCTs) that were registered were less likely to report positive study findings compared with RCTs that were not registered and whether the association varied by funding source.Design Cross sectional study.Study sample All primary RCTs published in December 2012 and indexed in PubMed by November 2013. Trial registration was determined based on the report of a trial registration number in published RCTs or the identification of the trial in a search of trial registries...
March 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28196813/harms-of-outcome-switching-in-reports-of-randomised-trials-consort-perspective
#9
Douglas G Altman, David Moher, Kenneth F Schulz
No abstract text is available yet for this article.
February 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28188898/rating-of-included-trials-on-the-efficacy-effectiveness-spectrum-development-of-a-new-tool-for-systematic-reviews
#10
L Susan Wieland, Brian M Berman, Douglas G Altman, Jürgen Barth, Lex M Bouter, Christopher R D'Adamo, Klaus Linde, David Moher, C Daniel Mullins, Shaun Treweek, Sean Tunis, Danielle A van der Windt, Merrick Zwarenstein, Claudia Witt
BACKGROUND AND OBJECTIVE: Randomized trials may be designed to provide evidence more strongly related to efficacy or effectiveness of an intervention. When systematic reviews are used to inform clinical or policy decisions, it is important to know the efficacy-effectiveness nature of the included trials. The objective of this study was to develop a tool to characterize randomized trials included in a systematic review on an efficacy-effectiveness continuum. METHODS: We extracted rating domains and descriptors from existing tools and used a modified Delphi procedure to condense the domains and develop a new tool...
February 7, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28137831/stard-2015-guidelines-for-reporting-diagnostic-accuracy-studies-explanation-and-elaboration
#11
Jérémie F Cohen, Daniël A Korevaar, Douglas G Altman, David E Bruns, Constantine A Gatsonis, Lotty Hooft, Les Irwig, Deborah Levine, Johannes B Reitsma, Henrica C W de Vet, Patrick M M Bossuyt
Diagnostic accuracy studies are, like other clinical studies, at risk of bias due to shortcomings in design and conduct, and the results of a diagnostic accuracy study may not apply to other patient groups and settings. Readers of study reports need to be informed about study design and conduct, in sufficient detail to judge the trustworthiness and applicability of the study findings. The STARD statement (Standards for Reporting of Diagnostic Accuracy Studies) was developed to improve the completeness and transparency of reports of diagnostic accuracy studies...
November 14, 2016: BMJ Open
https://www.readbyqxmd.com/read/28114958/review-and-publication-of-protocol-submissions-to-trials-what-have-we-learned-in-10%C3%A2-years
#12
EDITORIAL
Tianjing Li, Isabelle Boutron, Rustam Al-Shahi Salman, Erik Cobo, Ella Flemyng, Jeremy M Grimshaw, Douglas G Altman
Trials has 10 years of experience in providing open access publication of protocols for randomised controlled trials. In this editorial, the senior editors and editors-in-chief of Trials discuss editorial issues regarding managing trial protocol submissions, including the content and format of the protocol, timing of submission, approaches to tracking protocol amendments, and the purpose of peer reviewing a protocol submission. With the clarification and guidance provided, we hope we can make the process of publishing trial protocols more efficient and useful to trial investigators and readers...
December 16, 2016: Trials
https://www.readbyqxmd.com/read/28042971/left-ventricular-rotational-mechanics-in-early-infancy-normal-reference-ranges-and-reproducibility-of-peak-values-and-time-to-peak-values
#13
Shiraz A Maskatia, Wesley Lee, Carolyn A Altman, Nancy A Ayres, Douglas K Feagin, Ricardo H Pignatelli
INTRODUCTION: Left ventricular cardiac twist and torsion values have been described in premature and term neonates, but not in early infancy. Early and late peak untwist rates and time to peak (TTP) values have not been described in infants. METHODS: 53 term infants were enrolled prospectively. The following parameters were obtained by two blinded observers at 1-2months postnatal age: peak twist and torsion (twist indexed to LV length), peak twist rate and torsion rate, TTP twist, early peak untwist rate, TTP early untwist rate, late peak untwist rate, TTP late untwist rate...
December 30, 2016: Early Human Development
https://www.readbyqxmd.com/read/27959712/randomized-trial-of-bilateral-versus-single-internal-thoracic-artery-grafts
#14
RANDOMIZED CONTROLLED TRIAL
David P Taggart, Douglas G Altman, Alastair M Gray, Belinda Lees, Stephen Gerry, Umberto Benedetto, Marcus Flather
BACKGROUND: The use of bilateral internal thoracic (mammary) arteries for coronary-artery bypass grafting (CABG) may improve long-term outcomes as compared with the use of a single internal-thoracic-artery plus vein grafts. METHODS: We randomly assigned patients scheduled for CABG to undergo single or bilateral internal-thoracic-artery grafting in 28 cardiac surgical centers in seven countries. The primary outcome was death from any cause at 10 years. The composite of death from any cause, myocardial infarction, or stroke was a secondary outcome...
December 29, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27956535/nccn-guidelines-insights-chronic-myeloid-leukemia-version-1-2017
#15
Arnel Pallera, Jessica K Altman, Ellin Berman, Camille N Abboud, Bhavana Bhatnagar, Peter Curtin, Daniel J DeAngelo, Jason Gotlib, R Tanner Hagelstrom, Gabriela Hobbs, Madan Jagasia, Hagop M Kantarjian, Patricia Kropf, Leland Metheny, Joseph O Moore, Evelena Ontiveros, Enkhtsetseg Purev, Albert Quiery, Vishnu V B Reddy, Michal G Rose, Neil P Shah, B Douglas Smith, David S Snyder, Kendra L Sweet, Raoul Tibes, David T Yang, Kristina Gregory, Hema Sundar, Michael Deininger, Jerald P Radich
The NCCN Guidelines for Chronic Myeloid Leukemia (CML) provide recommendations for the management of chronic-phase and advanced-phase CML in adult patients. The median age of disease onset is 67 years. However, because CML occurs in all age groups, clinical care teams should be prepared to address issues relating to fertility and pregnancy with patients who are of reproductive age at the time of diagnosis. CML is relatively rare in children and there are no evidence-based recommendations for the management of CML in pediatric population...
December 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27909653/magnetic-resonance-imaging-of-the-cervical-spine-under-represents-sagittal-plane-deformity-in-degenerative-myelopathy-patients
#16
Douglas S Weinberg, Arunit J Chugh, Jeremy J Gebhart, Jason D Eubanks
BACKGROUND: In treating patients with cervical myelopathy, surgical approach may be dictated by sagittal balance, highlighting the need for accurate pre-operative assessment. Magnetic Resonance Imaging (MRI) is widely-recognized for its utility in the diagnosis and surgical planning of cervical myelopathy. Plain radiographs (X-rays) are a reliable tool to assess bony alignment. However, they may not always be included in standard pre-operative evaluation, especially in an era of restricted payer-environments...
2016: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/27894295/impact-of-a-web-based-tool-webconsort-to-improve-the-reporting-of-randomised-trials-results-of-a-randomised-controlled-trial
#17
Sally Hopewell, Isabelle Boutron, Douglas G Altman, Ginny Barbour, David Moher, Victor Montori, David Schriger, Jonathan Cook, Stephen Gerry, Omar Omar, Peter Dutton, Corran Roberts, Eleni Frangou, Lei Clifton, Virginia Chiocchia, Ines Rombach, Karolina Wartolowska, Philippe Ravaud
BACKGROUND: The CONSORT Statement is an evidence-informed guideline for reporting randomised controlled trials. A number of extensions have been developed that specify additional information to report for more complex trials. The aim of this study was to evaluate the impact of using a simple web-based tool (WebCONSORT, which incorporates a number of different CONSORT extensions) on the completeness of reporting of randomised trials published in biomedical publications. METHODS: We conducted a parallel group randomised trial...
November 28, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27881078/no-rationale-for-1-variable-per-10-events-criterion-for-binary-logistic-regression-analysis
#18
Maarten van Smeden, Joris A H de Groot, Karel G M Moons, Gary S Collins, Douglas G Altman, Marinus J C Eijkemans, Johannes B Reitsma
BACKGROUND: Ten events per variable (EPV) is a widely advocated minimal criterion for sample size considerations in logistic regression analysis. Of three previous simulation studies that examined this minimal EPV criterion only one supports the use of a minimum of 10 EPV. In this paper, we examine the reasons for substantial differences between these extensive simulation studies. METHODS: The current study uses Monte Carlo simulations to evaluate small sample bias, coverage of confidence intervals and mean square error of logit coefficients...
November 24, 2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27821614/international-standards-for-symphysis-fundal-height-based-on-serial-measurements-from-the-fetal-growth-longitudinal-study-of-the-intergrowth-21st-project-prospective-cohort-study-in-eight-countries
#19
MULTICENTER STUDY
Aris T Papageorghiou, Eric O Ohuma, Michael G Gravett, Jane Hirst, Mariangela F da Silveira, Ann Lambert, Maria Carvalho, Yasmin A Jaffer, Douglas G Altman, Julia A Noble, Enrico Bertino, Manorama Purwar, Ruyan Pang, Leila Cheikh Ismail, Cesar Victora, Zulfiqar A Bhutta, Stephen H Kennedy, José Villar
OBJECTIVE:  To create international symphysis-fundal height standards derived from pregnancies of healthy women with good maternal and perinatal outcomes. DESIGN:  Prospective longitudinal observational study. SETTING:  Eight geographically diverse urban regions in Brazil, China, India, Italy, Kenya, Oman, United Kingdom, and United States. PARTICIPANTS:  Healthy, well nourished pregnant women enrolled into the Fetal Growth Longitudinal Study component of the INTERGROWTH-21(st) Project at 9-14 weeks' gestation, and followed up until birth...
November 7, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27789483/very-large-treatment-effects-in-randomised-trials-as-an-empirical-marker-to-indicate-whether-subsequent-trials-are-necessary-meta-epidemiological-assessment
#20
Myura Nagendran, Tiago V Pereira, Grace Kiew, Douglas G Altman, Mahiben Maruthappu, John P A Ioannidis, Peter McCulloch
OBJECTIVE:  To examine whether a very large effect (VLE; defined as a relative risk of ≤0.2 or ≥5) in a randomised trial could be an empirical marker that subsequent trials are unnecessary. DESIGN:  Meta-epidemiological assessment of existing published data on randomised trials. DATA SOURCES:  Cochrane Database of Systematic Reviews (2010, issue 7) with data on subsequent large trials updated to 2015, issue 12. ELIGIBILITY CRITERIA:  All binary outcome forest plots were selected, which contained an index randomised trial with a VLE that was nominally statistically significant (P<0...
October 27, 2016: BMJ: British Medical Journal
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