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JOURNAL ARTICLE
Nicole Filipow, Melanie Bladen, Emma Raywood, Elisabeth Robinson, Deepti Chugh, Helen Douglas, Nikki Thorpe, Rachel O'Connor, Nicky Murray, Eleanor Main
AIMS: The aim was to evaluate whether standardised exercise performance during the incremental shuttle walk test (ISWT) can be used to assess disease severity in children and young people (CYP) with chronic conditions, through (1) identifying the most appropriate paediatric normative reference equation for the ISWT, (2) assessing how well CYP with haemophilia and cystic fibrosis (CF) perform against the values predicted by the best fit reference equation and (3) evaluating the association between standardised ISWT performance and disease severity...
March 8, 2024: BMJ Open
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JOURNAL ARTICLE
Joseph J Crisco, Julia A Henke, Daniel G McDermott, Rohit Badida, Amy M Morton, Josephine M Kalshoven, Douglas C Moore
Understanding the loads that occur across musculoskeletal joints is critical to advancing our understanding of joint function and pathology, implant design and testing, as well as model verification. Substantial work in these areas has occurred in the hip and knee but has not yet been undertaken in smaller joints, such as those in the wrist. The thumb carpometacarpal (CMC) joint is a uniquely human articulation that is also a common site of osteoarthritis with unknown etiology. We present two potential designs for an instrumented trapezium implant and compare approaches to load calibration...
February 21, 2024: Journal of Biomechanics
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JOURNAL ARTICLE
Neil P Shah, Ravi Bhatia, Jessica K Altman, Maria Amaya, Kebede H Begna, Ellin Berman, Onyee Chan, Joan Clements, Robert H Collins, Peter T Curtin, Daniel J DeAngelo, Michael Drazer, Lori Maness, Leland Metheny, Sanjay Mohan, Joseph O Moore, Vivian Oehler, Keith Pratz, Iskra Pusic, Michal G Rose, William Shomali, B Douglas Smith, Michael Styler, Moshe Talpaz, Tiffany N Tanaka, Srinivas Tantravahi, James Thompson, Steven Tsai, Jennifer Vaughn, Jeanna Welborn, David T Yang, Hema Sundar, Kristina Gregory
Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome resulting from a reciprocal translocation between chromosomes 9 and 22 [t9;22] that gives rise to a BCR::ABL1 fusion gene. CML occurs in 3 different phases (chronic, accelerated, and blast phase) and is usually diagnosed in the chronic phase in developed countries. Tyrosine kinase inhibitor (TKI) therapy is a highly effective treatment option for patients with chronic phase-CML. The primary goal of TKI therapy in patients with chronic phase-CML is to prevent disease progression to accelerated phase-CML or blast phase-CML...
February 2024: Journal of the National Comprehensive Cancer Network: JNCCN
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JOURNAL ARTICLE
Randolph M Baral, Susan M Jaensch, Douglas A Hayward, Kathleen P Freeman
BACKGROUND: Point-of-care (POC) biochemistry analyzers are widely used in small animal clinical practice but infrequently independently assessed for performance. OBJECTIVE: To assess the performance of two current model point-of-care biochemistry analyzers (Heska Element DC and IDEXX Catalyst) compared with a commercial laboratory analyzer (Cobas 8000). METHODS: One hundred twenty-one cats from a feline hospital population were sampled with plasma results from a single lithium heparin tube assessed on all three analyzers...
February 6, 2024: Veterinary Clinical Pathology
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JOURNAL ARTICLE
Leandro Moreira Peres, Fabio Luis-Silva, Mayra Gonçalves Menegueti, Wilson José Lovato, Douglas Alexandre do Espirito Santo, Mariana Derminio Donadel, Lucas Sato, Carolina Hunger Malek-Zadeh, Anibal Basile-Filho, Olindo Assis Martins-Filho, Maria Auxiliadora-Martins
BACKGROUND & AIM: Among critical patients, there is an early onset of changes in both the quantity and quality of muscle mass. It is essential to find tools that promptly identify this muscle mass loss. The aim of this study was to compare the ultrasonography of the quadriceps femoris to the gold standard, thigh computed tomography (CT) for assessing the musculature of critically ill patients with different body mass index who have suffered traumatic brain injury. METHODS: This is a prospective validation study in an Intensive Care Unit (ICU) specialized in trauma care, located at a tertiary teaching hospital...
February 2024: Clinical Nutrition ESPEN
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JOURNAL ARTICLE
Ellin Berman, Neil P Shah, Michael Deninger, Jessica K Altman, Maria Amaya, Kebede Begna, Ravi Bhatia, Onyee Chan, Robert Collins, Peter Curtin, Daniel J DeAngelo, Michael Drazer, Lori Maness, Leland Metheny, Sanjay Mohan, Joseph Moore, Vivian Oehler, Keith Pratz, Iskra Pusic, Michal Rose, William Shomali, B Douglas Smith, Michael Styler, Kendra Sweet, Moshe Talpaz, Tiffany Tanaka, Srinivas Tantravahi, Steven Tsai, Jennifer Vaughn, Jeanna Welborn, David Yang, Michael Mauro, Jorge Cortes, Jerald Radich, Brian Druker
No abstract text is available yet for this article.
December 12, 2023: Journal of Clinical Oncology
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JOURNAL ARTICLE
Jason B Tabor, Jean-Michel Galarneau, Linden C Penner, Jennifer Cooper, Mohammad Ghodsi, Douglas D Fraser, Cheryl L Wellington, Chantel T Debert, Carolyn A Emery
IMPORTANCE: Advancing research on fluid biomarkers associated with sport-related concussion (SRC) highlights the importance of detecting low concentrations using ultrasensitive platforms. However, common statistical practices may overlook replicate errors and specimen exclusion, emphasizing the need to explore robust modeling approaches that consider all available replicate data for comprehensive understanding of sample variation and statistical inferences. OBJECTIVE: To evaluate the impact of replicate error and different biostatistical modeling approaches on SRC biomarker interpretation...
October 2, 2023: JAMA Network Open
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JOURNAL ARTICLE
Prubpreet Chaggar, Tina Tellum, Abigail Cohen, Davor Jurkovic
INTRODUCTION: The number and invasion depth of endometriotic bowel lesions, total length of bowel affected by endometriosis, lesion-to-anal verge distance, and extent of pouch of Douglas obliteration are important factors in preoperatively determining risk and complexity of endometriosis surgery. The intra- and interobserver reproducibility of transvaginal ultrasound in the evaluation of many of these parameters has not yet been investigated. Our study aimed to assess the intra- and interobserver reproducibility of transvaginal ultrasound between an experienced and less experienced examiner for all of these parameters...
August 28, 2023: Acta Obstetricia et Gynecologica Scandinavica
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JOURNAL ARTICLE
Nicholas Ravanelli, Douglas Newhouse, Fergus Foster, Aaron R Caldwell
The present study assessed agreement between a wireless sweat rate monitor (KuduSmart® device) and the ventilated capsule (VC) technique for measuring: i) minute-averaged local sweat rate (LSR); ii) sweating onset; iii) sudomotor thermosensitivity; and iv) steady-state LSR, during passive heat stress and exercise. It was hypothesized that acceptable agreement with no bias would be observed between techniques for all assessed sweating characteristics. On two separate occasions for each intervention, participants were either passively heated by recirculating hot water (49°C) through a tube-lined garment until rectal temperature increased 1°C over baseline (n=8), or a 60-minute treadmill march at a fixed rate of heat production (~500W, n=9)...
August 11, 2023: Applied Physiology Nutrition and Metabolism
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JOURNAL ARTICLE
Lalita Gupta, Eric L Peterson, Cody Williams, Emily Altman, Ryan Harpole, Douglas J Martin, Edward J Escott, Peter J Timoney, Mark A Prendes
PURPOSE: To describe the findings of diffusion-weighted imaging (DWI) for a series of orbital lesions and provide a systematic review of relevant literature. METHODS: A retrospective review of 20 patients with orbital lesions who underwent MRI with DWI at two academic institutions between 2015 and 2020 was performed. Lesion diagnosis was histopathologically confirmed except a presumed cavernous hemangioma. Echoplanar diffusion-weighted images had been acquired using 2 or 3 b values (b=0 and 1000 or b=0, 500, and 1000) at 1...
February 9, 2023: Ophthalmic Plastic and Reconstructive Surgery
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JOURNAL ARTICLE
Yasuki Sekiguchi, David G Martin, Ayami Yoshihara, Douglas J Casa
PURPOSE: The purpose of this study was to investigate associations between digital urine color and paper urine color with other urine indices to assess hydration status. METHODS: Twelve male subjects (mean ± standard deviation; age, 26 ± 8 years; body mass, 57.8 ± 5.3 kg; height, 177.5 ± 8.9 cm; VO2max , 57.8 ± 5.8 ml·kg-1 ·min-1 ) performed four exercise trials in the heat...
February 1, 2023: European Journal of Nutrition
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JOURNAL ARTICLE
Sihyung Lee, Kuniko Moto, Taewoong Oh, Motoko Taguchi
PURPOSE: This study aimed to evaluate the differences between predicted resting energy expenditure (REE), using fat-free mass (FFM)-based prediction equations, and measured REE in Korean male collegiate soccer players. METHODS: Fifteen male collegiate soccer players (18-21 years) participated in this study. The REE measurements were conducted using the Douglas bag method. Body composition was measured by dual-energy X-ray absorptiometry (DXA). The differences between the measured REE and predicted REE, using the five FFM-based REE equations, were analyzed using the t-test, calculation of errors, regression analysis, and the Bland-Altman method...
September 2022: Physical activity and nutrition
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JOURNAL ARTICLE
Andrew G Dubina, George Morcos, Nathan N O'Hara, Givenchy W Manzano, Heather A Vallier, Hassan Farooq, Roman M Natoli, Donald Adams, William T Obremskey, Brandon G Wilkinson, Matthew Hogue, Justin M Haller, Lucas S Marchand, Gavin Hautala, Paul E Matuszewski, Guillermo R Pechero, Joshua L Gary, Christopher J Doro, Paul S Whiting, Michael J Chen, Malcolm R DeBaun, Michael J Gardner, Alan W Reynolds, Gregory T Altman, Mitchel R Obey, Anna N Miller, Douglas Haase, Brent Wise, Austin Wallace, Jennifer Hagen, Jeffrey O'Donnell, Mark Gage, Nicholas R Johnson, Madhav Karunakar, Joseph Dynako, John Morellato, Zachary A Panton, I Leah Gitajn, Lucas Haase, George Ochenjele, Erika Roddy, Saam Morshed, Abigail E Sagona, Tyler D Caton, Michael J Weaver, Jerald R Westberg, Jose San Miguel, Robert V O'Toole
BACKGROUND: Tibial plateau fractures with an ipsilateral compartment syndrome are a clinical challenge with limited guidance regarding the best time to perform open reduction and internal fixation (ORIF) relative to fasciotomy wound closure. This study aimed to determine if the risk of fracture-related infection (FRI) differs based on the timing of tibial plateau ORIF relative to closure of ipsilateral fasciotomy wounds. METHODS: A retrospective cohort study identified patients with tibial plateau fractures and an ipsilateral compartment syndrome treated with 4-compartment fasciotomy at 22 US trauma centers from 2009 to 2019...
August 24, 2022: Injury
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JOURNAL ARTICLE
Yenni E Cedillo, Rachel O Knight, Betty Darnell, Jose R Fernandez, Douglas R Moellering
Dual-energy x-ray absorptiometry (DXA) is considered to have high accuracy in estimating fat mass; however, DXA is not always available. We hypothesized that the equations most commonly used for predicting body fat percentage (BF%) using skinfold thickness agree with direct measures of BF% obtained by DXA scan in African American (AA) and Caucasian American (CA) women. Data from 42 women from Alabama who were 21 to 45 years of age, who self-identify as AA (n = 20) or CA (n = 22) were included. BF% was estimated using DXA scan and through 6 different skinfold thickness equations...
August 6, 2022: Nutrition Research
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JOURNAL ARTICLE
Jingjing Liang, Javier G P Gamarra, Nicolas Picard, Mo Zhou, Bryan Pijanowski, Douglass F Jacobs, Peter B Reich, Thomas W Crowther, Gert-Jan Nabuurs, Sergio de-Miguel, Jingyun Fang, Christopher W Woodall, Jens-Christian Svenning, Tommaso Jucker, Jean-Francois Bastin, Susan K Wiser, Ferry Slik, Bruno Hérault, Giorgio Alberti, Gunnar Keppel, Geerten M Hengeveld, Pierre L Ibisch, Carlos A Silva, Hans Ter Steege, Pablo L Peri, David A Coomes, Eric B Searle, Klaus von Gadow, Bogdan Jaroszewicz, Akane O Abbasi, Meinrad Abegg, Yves C Adou Yao, Jesús Aguirre-Gutiérrez, Angelica M Almeyda Zambrano, Jan Altman, Esteban Alvarez-Dávila, Juan Gabriel Álvarez-González, Luciana F Alves, Bienvenu H K Amani, Christian A Amani, Christian Ammer, Bhely Angoboy Ilondea, Clara Antón-Fernández, Valerio Avitabile, Gerardo A Aymard, Akomian F Azihou, Johan A Baard, Timothy R Baker, Radomir Balazy, Meredith L Bastian, Rodrigue Batumike, Marijn Bauters, Hans Beeckman, Nithanel Mikael Hendrik Benu, Robert Bitariho, Pascal Boeckx, Jan Bogaert, Frans Bongers, Olivier Bouriaud, Pedro H S Brancalion, Susanne Brandl, Francis Q Brearley, Jaime Briseno-Reyes, Eben N Broadbent, Helge Bruelheide, Erwin Bulte, Ann Christine Catlin, Roberto Cazzolla Gatti, Ricardo G César, Han Y H Chen, Chelsea Chisholm, Emil Cienciala, Gabriel D Colletta, José Javier Corral-Rivas, Anibal Cuchietti, Aida Cuni-Sanchez, Javid A Dar, Selvadurai Dayanandan, Thales de Haulleville, Mathieu Decuyper, Sylvain Delabye, Géraldine Derroire, Ben DeVries, John Diisi, Tran Van Do, Jiri Dolezal, Aurélie Dourdain, Graham P Durrheim, Nestor Laurier Engone Obiang, Corneille E N Ewango, Teresa J Eyre, Tom M Fayle, Lethicia Flavine N Feunang, Leena Finér, Markus Fischer, Jonas Fridman, Lorenzo Frizzera, André L de Gasper, Damiano Gianelle, Henry B Glick, Maria Socorro Gonzalez-Elizondo, Lev Gorenstein, Richard Habonayo, Olivier J Hardy, David J Harris, Andrew Hector, Andreas Hemp, Martin Herold, Annika Hillers, Wannes Hubau, Thomas Ibanez, Nobuo Imai, Gerard Imani, Andrzej M Jagodzinski, Stepan Janecek, Vivian Kvist Johannsen, Carlos A Joly, Blaise Jumbam, Banoho L P R Kabelong, Goytom Abraha Kahsay, Viktor Karminov, Kuswata Kartawinata, Justin N Kassi, Elizabeth Kearsley, Deborah K Kennard, Sebastian Kepfer-Rojas, Mohammed Latif Khan, John N Kigomo, Hyun Seok Kim, Carine Klauberg, Yannick Klomberg, Henn Korjus, Subashree Kothandaraman, Florian Kraxner, Amit Kumar, Relawan Kuswandi, Mait Lang, Michael J Lawes, Rodrigo V Leite, Geoffrey Lentner, Simon L Lewis, Moses B Libalah, Janvier Lisingo, Pablito Marcelo López-Serrano, Huicui Lu, Natalia V Lukina, Anne Mette Lykke, Vincent Maicher, Brian S Maitner, Eric Marcon, Andrew R Marshall, Emanuel H Martin, Olga Martynenko, Faustin M Mbayu, Musingo T E Mbuvi, Jorge A Meave, Cory Merow, Stanislaw Miscicki, Vanessa S Moreno, Albert Morera, Sharif A Mukul, Jörg C Müller, Agustinus Murdjoko, Maria Guadalupe Nava-Miranda, Litonga Elias Ndive, Victor J Neldner, Radovan V Nevenic, Louis N Nforbelie, Michael L Ngoh, Anny E N'Guessan, Michael R Ngugi, Alain S K Ngute, Emile Narcisse N Njila, Melanie C Nyako, Thomas O Ochuodho, Jacek Oleksyn, Alain Paquette, Elena I Parfenova, Minjee Park, Marc Parren, Narayanaswamy Parthasarathy, Sebastian Pfautsch, Oliver L Phillips, Maria T F Piedade, Daniel Piotto, Martina Pollastrini, Lourens Poorter, John R Poulsen, Axel Dalberg Poulsen, Hans Pretzsch, Mirco Rodeghiero, Samir G Rolim, Francesco Rovero, Ervan Rutishauser, Khosro Sagheb-Talebi, Purabi Saikia, Moses Nsanyi Sainge, Christian Salas-Eljatib, Antonello Salis, Peter Schall, Dmitry Schepaschenko, Michael Scherer-Lorenzen, Bernhard Schmid, Jochen Schöngart, Vladimír Šebeň, Giacomo Sellan, Federico Selvi, Josep M Serra-Diaz, Douglas Sheil, Anatoly Z Shvidenko, Plinio Sist, Alexandre F Souza, Krzysztof J Stereńczak, Martin J P Sullivan, Somaiah Sundarapandian, Miroslav Svoboda, Mike D Swaine, Natalia Targhetta, Nadja Tchebakova, Liam A Trethowan, Robert Tropek, John Tshibamba Mukendi, Peter Mbanda Umunay, Vladimir A Usoltsev, Gaia Vaglio Laurin, Riccardo Valentini, Fernando Valladares, Fons van der Plas, Daniel José Vega-Nieva, Hans Verbeeck, Helder Viana, Alexander C Vibrans, Simone A Vieira, Jason Vleminckx, Catherine E Waite, Hua-Feng Wang, Eric Katembo Wasingya, Chemuku Wekesa, Bertil Westerlund, Florian Wittmann, Verginia Wortel, Tomasz Zawiła-Niedźwiecki, Chunyu Zhang, Xiuhai Zhao, Jun Zhu, Xiao Zhu, Zhi-Xin Zhu, Irie C Zo-Bi, Cang Hui
The latitudinal diversity gradient (LDG) is one of the most recognized global patterns of species richness exhibited across a wide range of taxa. Numerous hypotheses have been proposed in the past two centuries to explain LDG, but rigorous tests of the drivers of LDGs have been limited by a lack of high-quality global species richness data. Here we produce a high-resolution (0.025° × 0.025°) map of local tree species richness using a global forest inventory database with individual tree information and local biophysical characteristics from ~1...
August 8, 2022: Nature Ecology & Evolution
#16
JOURNAL ARTICLE
Suvajit Koley, Kaylee T Cayton, Gisela A González-Montiel, M Ramu Yadav, Douglas L Orsi, Andrew J Intelli, Paul Ha-Yeon Cheong, Ryan A Altman
A Cu-based catalyst system convergently couples gem -difluoroalkenes with phenols under aerobic conditions to deliver α,α-difluorinated-α-phenoxyketones, an unstudied hybrid fluorinated functional group. Composed of α,α-difluorinated ketone and α,α-difluorinated ether moieties, these compounds have rarely been reported as a synthetic intermediate. Computational predictions and later experimental corroboration suggest that the phenoxy-substituted fluorinated ketone's sp3 -hybridized hydrate form is energetically favored relative to the respective nonether variant and that perturbation of the electronic character of the ketone can further encourage the formation of the hydrate...
August 19, 2022: Journal of Organic Chemistry
#17
JOURNAL ARTICLE
Benjamin Speich, Ayodele Odutayo, Nicholas Peckham, Alexander Ooms, Jamie R Stokes, Ramon Saccilotto, Dmitry Gryaznov, Belinda von Niederhäusern, Bethan Copsey, Douglas G Altman, Matthias Briel, Sally Hopewell
BACKGROUND: To assess the quality of reporting of RCT protocols approved by UK research ethics committees before and after the publication of the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guideline. METHODS: We had access to RCT study protocols that received ethical approval in the UK in 2012 (n=103) and 2016 (n=108). From those, we assessed the adherence to the 33 SPIRIT items (i.e. a total of 64 components of the 33 SPIRIT items)...
July 27, 2022: Trials
#18
JOURNAL ARTICLE
Katie A Hoban, Samantha Downie, Douglas J A Adamson, James G MacLean, Paul Cool, Arpit C Jariwala
Hypothesis: The aim of this study was to investigate the reproducibility, reliability, and accuracy of Mirels' score in upper limb bony metastatic disease and validate its use in predicting pathologic fractures. Methods: Forty-five patients with upper limb bony metastases met the inclusion criteria (62% male 28/45). The mean age was 69 years (SD 9.5), and the most common primaries were lung (29%, 13/45), followed by prostate and hematological (each 20%, 9/45). The most commonly affected bone was the humerus (76%, 35/45), followed by the ulna (6...
July 2022: JSES international
#19
JOURNAL ARTICLE
Kevin M Magnaye, Selene M Clay, Jessie Nicodemus-Johnson, Katherine A Naughton, Janel Huffman, Matthew C Altman, Daniel J Jackson, James E Gern, Douglas K Hogarth, Edward T Naureckas, Steven R White, Carole Ober
Maternal asthma (MA) is among the most consistent risk factors for asthma in children. Possible mechanisms for this observation are epigenetic modifications in utero that have lasting effects on developmental programs in children of mothers with asthma. To test this hypothesis, we performed differential DNA methylation analyses of 398,186 individual CpG sites in primary bronchial epithelial cells (BECs) from 42 nonasthma controls and 88 asthma cases, including 56 without MA (NMA) and 32 with MA. We used weighted gene coexpression network analysis (WGCNA) of 69 and 554 differentially methylated CpGs (DMCs) that were specific to NMA and MA cases, respectively, compared with controls...
June 14, 2022: Proceedings of the National Academy of Sciences of the United States of America
#20
JOURNAL ARTICLE
Mark Q Wilber, Michel E B Ohmer, Karie A Altman, Laura A Brannelly, Brandon C LaBumbard, Emily H Le Sage, Nina B McDonnell, Aura Y Muñiz Torres, Caitlin L Nordheim, Ferdinand Pfab, Corinne L Richards-Zawacki, Louise A Rollins-Smith, Veronica Saenz, Jamie Voyles, Daniel P Wetzel, Douglas C Woodhams, Cheryl J Briggs
Host species that can independently maintain a pathogen in a host community and contribute to infection in other species are important targets for disease management. However, the potential of host species to maintain a pathogen is not fixed over time, and an important challenge is understanding how within- and across-season variability in host maintenance potential affects pathogen persistence over longer time scales relevant for disease management (e.g., years). Here, we sought to understand the causes and consequences of seasonal infection dynamics in leopard frogs (Rana sphenocephala and Rana pipiens) infected with the fungal pathogen Batrachochytrium dendrobatidis (Bd)...
September 2022: Ecology
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