Pedram Parnianpour, Michael Benatar, Hannah Briemberg, Avyarthana Dey, Annie Dionne, Nicolas Dupré, Karleyton C Evans, Richard Frayne, Angela Genge, Simon J Graham, Lawrence Korngut, Donald G McLaren, Peter Seres, Robert C Welsh, Alan Wilman, Lorne Zinman, Sanjay Kalra
This study aimed to investigate the clinical stratification of amyotrophic lateral sclerosis (ALS) patients in relation to in vivo cerebral degeneration. One hundred forty-nine ALS patients and one hundred forty-four healthy controls (HCs) were recruited from the Canadian ALS Neuroimaging Consortium (CALSNIC). Texture analysis was performed on T1-weighted scans to extract the texture feature "autocorrelation" (autoc), an imaging biomarker of cerebral degeneration. Patients were stratified at baseline into early and advanced disease stages based on criteria adapted from ALS clinical trials and the King's College staging system, as well as into slow and fast progressors (disease progression rates, DPR)...
January 28, 2024: Journal of Neurology