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Augmentation depression

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https://www.readbyqxmd.com/read/29448886/augmenting-treatment-efficiency-in-exposure-therapy-for-ptsd-a-randomized-double-blind-placebo-controlled-trial-of-yohimbine-hcl
#1
Peter W Tuerk, Bethany C Wangelin, Mark B Powers, Jasper A J Smits, Ron Acierno, Ursula S Myers, Scott P Orr, Edna B Foa, Mark B Hamner
The alpha-2 adrenergic receptor antagonist, yohimbine, can facilitate fear extinction in animals and humans. One potential mechanism is increased noradrenergic activity and associated arousal in the presence of conditioned stimuli. Accordingly, yohimbine might augment prolonged exposure (PE) therapy for posttraumatic stress disorder (PTSD), where heightened exposure-oriented arousal is a theorized driver and empirical predictor of treatment success. A double-blind placebo-controlled randomized trial (NCT 01031979) piloted yohimbine augmentation in 26 males with combat-related PTSD...
February 15, 2018: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/29442609/caveat-emptor-folate-in-unipolar-depressive-illness-a-systematic-review-and-meta-analysis
#2
Emmert Roberts, Ben Carter, Allan H Young
BACKGROUND: International guideline recommendations for the use of folate and its derivatives in the treatment of unipolar depressive disorders are confused and contradictory, perhaps reflecting wide variations in the underpinning evidence base. INTRODUCTION: We discuss differing methods of evidence synthesis in the formulation of international guideline recommendations. As an example we evaluated the efficacy of folate and its derivatives in unipolar depression via systematic review and meta-analysis...
February 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29438400/nocturnal-insomnia-symptoms-and-stress-induced-cognitive-intrusions-in-risk-for-depression-a-2-year-prospective-study
#3
David A Kalmbach, Vivek Pillai, Christopher L Drake
Nearly half of US adults endorse insomnia symptoms. Sleep problems increase risk for depression during stress, but the mechanisms are unclear. During high stress, individuals having difficulty falling or staying asleep may be vulnerable to cognitive intrusions after stressful events, given that the inability to sleep creates a period of unstructured and socially isolated time in bed. We investigated the unique and combined effects of insomnia symptoms and stress-induced cognitive intrusions on risk for incident depression...
2018: PloS One
https://www.readbyqxmd.com/read/29438225/traits-associated-with-central-pain-augmentation-in-the-knee-pain-in-the-community-kpic-cohort
#4
Kehinde Akin-Akinyosoye, Nadia Frowd, Laura Marshall, Joanne Stocks, Gwen Fernandes, Ana Valdes, Daniel F McWilliams, Weiya Zhang, Michael Doherty, Eamonn Ferguson, David A Walsh
This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n=420) in the Knee Pain and related health In the Community (KPIC) baseline survey undertook pressure pain threshold (PPT) assessments. Items measuring specific traits related to central pain mechanisms were selected from the survey based on expert consensus, face validity, item association to underlying constructs measured by originating host questionnaires, adequate targeting and PPT correlations...
February 9, 2018: Pain
https://www.readbyqxmd.com/read/29433063/effects-of-tandospirone-augmentation-in-major-depressive-disorder-patients-with-high-anxiety-a-multicenter-randomized-parallel-controlled-open-label-study
#5
Jingyu Lin, Yunai Su, Chunxia Wang, Fude Yang, Yi Xu, Yonggui Yuan, Yefeng Yuan, Xiaoping Wang, Xin Yu, Tianmei Si
BACKGROUND: High levels of anxiety symptoms are common in individuals with major depressive disorder (MDD). Adjunctive anxiolytics are widely used in such patients; however, only a few studies have examined the strategy using tandospirone. This study aimed to evaluate the efficacy and safety of adjunctive tandospirone in individuals with MDD and high level of anxiety symptoms. METHODS: A multicenter, randomized, parallel-controlled, open-label study was conducted to evaluate the efficacy and safety of tandospirone coupled with selective serotonin reuptake inhibitors (SSRIs) in patients with MDD and high level of anxiety symptoms...
February 9, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29431197/efficacy-and-safety-of-antidepressant-augmentation-of-continued-antipsychotic-treatment-in-patients-with-schizophrenia
#6
B Galling, J A Vernon, A K Pagsberg, A Wadhwa, E Grudnikoff, A J Seidman, M Tsoy-Podosenin, M Poyurovsky, J M Kane, C U Correll
OBJECTIVE: To evaluate the efficacy and safety of antidepressant augmentation of antipsychotics in schizophrenia. METHODS: Systematic literature search (PubMed/MEDLINE/PsycINFO/Cochrane Library) from database inception until 10/10/2017 for randomized, double-blind, efficacy-focused trials comparing adjunctive antidepressants vs. placebo in schizophrenia. RESULTS: In a random-effects meta-analysis (studies = 42, n = 1934, duration = 10...
March 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29417623/serum-levels-of-interleukin-6-in-schizophrenic-patients-during-treatment-augmentation-with-sarcosine-results-of-the-pulsar-study
#7
Dominik Strzelecki, Małgorzata Urban-Kowalczyk, Adam Wysokiński
OBJECTIVE: Augmentation of sarcosine, a natural inhibitor of the glycine transporter type I, normalizes glutamatergic neurotransmission, having beneficial impact on primary negative symptoms in schizophrenia and may also influence immune system and interleukin 6 (IL-6) levels. AIM: Finding a relationship between initial IL-6 serum concentrations or its changes and severity of symptoms as a result of sarcosine addition to stable antipsychotic treatment. METHOD: Fifity-eight individuals with schizophrenia with predominantly negative symptoms completed a 6-month randomized, double-blind placebo-controlled prospective study...
February 7, 2018: Human Psychopharmacology
https://www.readbyqxmd.com/read/29409574/atypical-antipsychotics-in-late-life-and-treatment-resistant-depression
#8
Trista Askins Bailey, Sehrish Panjwani
As persons age, their risk of developing late-life depression increases. Older adults not only have an increased risk of late-life depression, but they also have an increased risk of suicidal ideation. Because of these increased risks, it is vital that clinicians be aware of the options available to assist these persons to achieve remission of their symptoms, as well as prevent relapse. Atypical antipsychotics have been considered an augmentation option in younger adults with depression. However, because of the black box warning associated with atypical antipsychotics in older adults with dementia, clinicians often exercise caution when using these agents to help treat late-life depression...
February 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29408901/impact-of-person-centred-care-training-and-person-centred-activities-on-quality-of-life-agitation-and-antipsychotic-use-in-people-with-dementia-living-in-nursing-homes-a-cluster-randomised-controlled-trial
#9
Clive Ballard, Anne Corbett, Martin Orrell, Gareth Williams, Esme Moniz-Cook, Renee Romeo, Bob Woods, Lucy Garrod, Ingelin Testad, Barbara Woodward-Carlton, Jennifer Wenborn, Martin Knapp, Jane Fossey
BACKGROUND: Agitation is a common, challenging symptom affecting large numbers of people with dementia and impacting on quality of life (QoL). There is an urgent need for evidence-based, cost-effective psychosocial interventions to improve these outcomes, particularly in the absence of safe, effective pharmacological therapies. This study aimed to evaluate the efficacy of a person-centred care and psychosocial intervention incorporating an antipsychotic review, WHELD, on QoL, agitation, and antipsychotic use in people with dementia living in nursing homes, and to determine its cost...
February 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29407535/change-in-1-year-hospitalization-of-overall-and-older-patients-with-major-depressive-disorder-after-second-generation-antipsychotics-augmentation-treatment
#10
Chun-Yuan Lin, Te-Jen Lai, Yu-Hsin Wu, Ping-Kun Chen, Yuan-Fu Lin, I-Chia Chien
BACKGROUND: Studies on second-generation antipsychotics (SGA) augmentation treatment for older adults with major depressive disorder (MDD) remain limited. We aimed to investigate the effectiveness of SGA augmentation for overall and older patients with MDD inpatient history by assessing the change in 1-year hospitalization before and after SGA augmentation using the latest National Health Insurance Research Database (NHIRD) in Taiwan. METHODS: The samples were MDD patients (ICD-9 CM code: 296...
January 31, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29397559/anti-oxidative-effects-of-melatonin-receptor-agonist-and-omega-3-polyunsaturated-fatty-acids-in-neuronal-sh-sy5y-cells-deciphering-synergic-effects-on-anti-depressant-mechanisms
#11
Senthil Kumaran Satyanarayanan, Yin-Hwa Shih, Yu-Chuan Chien, Shih-Yi Huang, Piotr Gałecki, Siegfried Kasper, Jane Pei-Chen Chang, Kuan-Pin Su
Omega-3 polyunsaturated fatty acids (n-3 or omega-3 PUFAs) and melatonin receptor agonist ramelteon (RMT) both display antidepressant effects, while their cellular effects on anti-oxidative and neuroprotective mechanisms might be different. In this study, we aimed to decipher the individual and synergistic actions of n-3 PUFAs and RMT, as compared with the conventional antidepressant fluoxetine (FLX), in a cellular model of oxidative stress, which might play an important role in the pathophysiology of depression and associated disorders...
February 3, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29396749/neuroticism-magnifies-the-detrimental-association-between-social-media-addiction-symptoms-and-wellbeing-in-women-but-not-in-men-a-three-way-moderation-model
#12
Ofir Turel, Natalie Tasha Poppa, Oren Gil-Or
Addiction symptoms in relation to the use of social networking sites (SNS) can be associated with reduced wellbeing. However, the mechanisms that can control this association have not been fully characterized, despite their relevance to effective treatment of individuals presenting SNS addiction symptoms. In this study we hypothesize that sex and neuroticism, which are important determinants of how people evaluate and respond to addiction symptoms, moderate this association. To examine these assertions, we employed hierarchical linear and logistic regression techniques to analyze data collected with a cross-sectional survey of 215 Israeli college students who use SNS...
February 3, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29389702/character-of-gluteal-region-morphology-in-young-chinese-females
#13
Saisai Cao, Zhe Peng, Ye Bi, Yan Liu, Kai Yang, Guangxue Li, Hui Tang, Huiran Zang, Youlei Qian, Xiangyu Liu, Ping Song, Lee L Q Pu, Lan Mu
BACKGROUND: The female gluteal morphology is an important secondary sexual characteristic and helps accentuate and define the female body shape. Despite the increasing prevalence of gluteal augmentations in our country, little data exist regarding the morphology of the gluteal region in young Chinese females. This study analyzed a convenience sample of Chinese females and their gluteal region. METHODS: Data, measurements, and photos of the following parameters were taken: age, weight, height, and body mass index (BMI)...
January 31, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29387159/effects-of-inbreeding-on-a-gregarious-parasitoid-wasp-with-complementary-sex-determination
#14
Tania Zaviezo, Romina Retamal, Teddy Urvois, Xavier Fauvergue, Aurélie Blin, Thibaut Malausa
Inbreeding and inbreeding depression are processes in small populations of particular interest for a range of human activities such as animal breeding, species conservation, or pest management. In particular, biological control programs should benefit from a thorough understanding of the causes and consequences of inbreeding because natural enemies experience repetitive bottlenecks during importation, laboratory rearing, and introduction. Predicting the effect of inbreeding in hymenopteran parasitoid wasps, frequently used in biological control programs, is nonetheless a difficult endeavor...
February 2018: Evolutionary Applications
https://www.readbyqxmd.com/read/29386176/the-effects-of-social-presence-on-adherence-focused-guidance-in-problematic-cannabis-users-protocol-for-the-canreduce-2-0-randomized-controlled-trial
#15
Manuel Amann, Severin Haug, Andreas Wenger, Christian Baumgartner, David D Ebert, Thomas Berger, Lars Stark, Marc Walter, Michael P Schaub
BACKGROUND: In European countries, including Switzerland, cannabis is the most commonly used illicit drug. Offering a Web-based self-help tool could potentially reach users who otherwise would not seek traditional help. However, such Web-based self-help tools often suffer from low adherence. OBJECTIVE: Through adherence-focused guidance enhancements, the aim of this study was to increase adherence in cannabis users entering a Web-based self-help tool to reduce their cannabis use and, in this way, augment its effectiveness...
January 31, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29381748/common-neural-structures-activated-by-epidural-and-transcutaneous-lumbar-spinal-cord-stimulation-elicitation-of-posterior-root-muscle-reflexes
#16
Ursula S Hofstoetter, Brigitta Freundl, Heinrich Binder, Karen Minassian
Epidural electrical stimulation of the lumbar spinal cord is currently regaining momentum as a neuromodulation intervention in spinal cord injury (SCI) to modify dysregulated sensorimotor functions and augment residual motor capacity. There is ample evidence that it engages spinal circuits through the electrical stimulation of large-to-medium diameter afferent fibers within lumbar and upper sacral posterior roots. Recent pilot studies suggested that the surface electrode-based method of transcutaneous spinal cord stimulation (SCS) may produce similar neuromodulatory effects as caused by epidural SCS...
2018: PloS One
https://www.readbyqxmd.com/read/29367224/the-effect-of-a-therapeutic-lithium-level-on-a-stroke-related-cerebellar-tremor
#17
Rachel A Orleans, Marc J Dubin, Kristopher A Kast
Lithium is a mood stabiliser used in the treatment of acute mania, bipolar disorder and as augmentation for unipolar major depression. Tremor is a common adverse effect associated with lithium at both therapeutic and toxic serum levels. We present a case of dose-dependent changes in the quality and intensity of a stroke-related, chronic cerebellar tremor with lithium treatment at serum levels within the therapeutic range. On admission, the patient in this case had a baseline fine, postural tremor, which increased in frequency and evolved to include myoclonic jerks once lithium therapy was initiated...
January 24, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29362444/treatment-of-bipolar-depression-with-minocycline-and-or-aspirin-an-adaptive-2%C3%A3-2-double-blind-randomized-placebo-controlled-phase-iia-clinical-trial
#18
Jonathan B Savitz, T Kent Teague, Masaya Misaki, Matt Macaluso, Brent E Wurfel, Matt Meyer, Douglas Drevets, William Yates, Ondria Gleason, Wayne C Drevets, Sheldon H Preskorn
Given evidence of chronic inflammation in bipolar disorder (BD), we tested the efficacy of aspirin and minocycline as augmentation therapy for bipolar depression. Ninety-nine depressed outpatients with BD were enrolled in a 6 week, double-blind, placebo-controlled trial, and randomized to one of four groups: active minocycline (100 mg b.i.d.) + active aspirin (81 mg b.i.d.) (M + A); active minocycline + placebo aspirin (M + P); placebo-minocycline + active aspirin (A + P); and placebo-minocycline + placebo aspirin (P + P)...
January 24, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29349820/an-experimental-test-of-alternative-population-augmentation-scenarios
#19
J A Kronenberger, J C Gerberich, S W Fitzpatrick, E D Broder, L M Angeloni, W C Funk
Human land use is fragmenting habitats worldwide and inhibiting dispersal among previously connected populations of organisms, often leading to inbreeding depression and reduced evolutionary potential in the face of rapid environmental change. One management practice used to combat this is the augmentation of isolated populations with immigrants as a means of demographic and genetic rescue. Augmentation with immigrants that are genetically and adaptively similar to the target population is highly effective at increasing population fitness, but if immigrants are very genetically or adaptively divergent, augmentation can lead to outbreeding depression...
January 19, 2018: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29343769/ckamp44-modulates-integration-of-visual-inputs-in-the-lateral-geniculate-nucleus
#20
Xufeng Chen, Muhammad Aslam, Tim Gollisch, Kevin Allen, Jakob von Engelhardt
Relay neurons in the dorsal lateral geniculate nucleus (dLGN) receive excitatory inputs from retinal ganglion cells (RGCs). Retinogeniculate synapses are characterized by a prominent short-term depression of AMPA receptor (AMPAR)-mediated currents, but the underlying mechanisms and its function for visual integration are not known. Here we identify CKAMP44 as a crucial auxiliary subunit of AMPARs in dLGN relay neurons, where it increases AMPAR-mediated current amplitudes and modulates gating of AMPARs. Importantly, CKAMP44 is responsible for the distinctive short-term depression in retinogeniculate synapses by reducing the rate of recovery from desensitization of AMPARs...
January 17, 2018: Nature Communications
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