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https://www.readbyqxmd.com/read/28525821/effect-of-exercise-augmentation-of-cognitive-behavioural-therapy-for-the-treatment-of-suicidal-ideation-and-depression
#1
Abbas Abdollahi, Daniel M LeBouthillier, Mahmoud Najafi, Gordon J G Asmundson, Simin Hosseinian, Shahriar Shahidi, Per Carlbring, Atefeh Kalhori, Hassan Sadeghi, Marzieh Jalili
BACKGROUND: Suicidal ideation and depression are prevalent and costly conditions that reduce quality of life. This study was designed to determine the efficacy of exercise as an adjunct to cognitive behavioural therapy (CBT) for suicidal ideation and depression among depressed individuals. METHODS: In a randomized clinical trial, 54 mildly to moderately depressed patients (54% female, mean age=48.25) were assigned to a combined CBT and exercise group or to a CBT only group...
May 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28521187/brain-antioxidant-effect-of-mirtazapine-and-reversal-of-sedation-by-its-combination-with-alpha-lipoic-acid-in-a-model-of-depression-induced-by-corticosterone
#2
Tatiana de Queiroz Oliveira, Caren Nádia Soares de Sousa, Germana Silva Vasconcelos, Luciene Costa de Sousa, Anneheydi Araújo de Oliveira, Cláudio Felipe Vasconcelos Patrocínio, Ingridy da Silva Medeiros, José Eduardo Ribeiro Honório Júnior, Michael Maes, Danielle Macedo, Silvânia Maria Mendes Vasconcelos
BACKGROUND: Depression is accompanied by activated neuro-oxidative and neuro-nitrosative pathways, while targeting these pathways has clinical efficacy in depression. This study aimed to investigate the effects of mirtazapine (MIRT) alone and combined with alpha-lipoic acid (ALA) against corticosterone (CORT) induced behavioral and oxidative alterations. METHODS: Male mice received vehicle or CORT 20mg/kg during 14 days. From the 15th to 21st days they were divided in groups administered: vehicle, MIRT 3mg/kg or the combinations MIRT+ALA100 or MIRT+ALA200...
May 11, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28514486/efficacy-of-42-pharmacologic-cotreatment-strategies-added-to-antipsychotic-monotherapy-in-schizophrenia-systematic-overview-and-quality-appraisal-of-the-meta-analytic-evidence
#3
Christoph U Correll, Jose M Rubio, Gabriella Inczedy-Farkas, Michael L Birnbaum, John M Kane, Stefan Leucht
Importance: Limited treatment responses in schizophrenia prompted the testing of combining an antipsychotic drug treatment with a second psychotropic medication. A comprehensive evaluation of the efficacy of multiple medication combinations is missing. Objective: To summarize and compare the meta-analytically determined efficacy of pharmacologic combination strategies of antipsychotic drugs in adults with schizophrenia. Data Sources: Systematic search of PubMed and PsycInfo until May 13, 2016...
May 17, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28505669/add-on-antidepressants-in-the-naturalistic-treatment-of-schizophrenia-spectrum-disorder-when-who-and-how
#4
Rebecca Schennach, Michael Obermeier, Florian Seemüller, Markus Jäger, Max Schmauss, Gerd Laux, Herbert Pfeiffer, Dieter Naber, Lutz G Schmidt, Wolfgang Gaebel, Joachim Klosterkötter, Isabella Heuser, Wolfgang Maier, Matthias R Lemke, Eckart Rüther, Stefan Klingberg, Markus Gastpar, Ilja Spellmann, Richard Musil, Hans-Jürgen Möller, Michael Riedel
The aim of this study was to evaluate antidepressant add-on treatment within the acute treatment of schizophrenia spectrum disorder patients. Antidepressant add-on was evaluated in 365 patients within a naturalistic multicenter study. Patients with/without antidepressant add-on were compared regarding clinical and treatment-related variables, response and remission, and remission of depressive and negative symptoms. The efficacy of antidepressant add-on treatment was furthermore analyzed applying marginal structure models...
May 15, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28491314/major-depressive-disorder-with-religious-struggle-and-completed-suicide-after-hair-transplantation
#5
Mehmet Emin Ceylan, Barış Önen Ünsalver, Alper Evrensel
OBJECTIVES: Psychological outcomes of aesthetic surgical procedures like hair transplantation are mostly positive including decreased anxiety, depression and social phobia and increased general well-being, self-efficacy and self-esteem. However, some patients may suffer from post-surgical depression and post-surgical increased suicide rates have been reported for breast augmentation patients. Difficulty adapting to the new image, unfulfilled psychological needs expected to be met by the surgery, side effects of the surgery like tissue swelling or bruising, uncontrolled pain, presence of body dysmorphic disorder and previous history of mood disorder may be some of the risk factors for post-surgical depression...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28486077/loneliness-and-suicidal-risk-in-young-adults-does-believing-in-a-changeable-future-help-minimize-suicidal-risk-among-the-lonely
#6
Edward C Chang, Liangqiu Wan, Pengzi Li, Yuncheng Guo, Jiaying He, Yu Gu, Yingjie Wang, Xiaoqing Li, Zhan Zhang, Yingrui Sun, Casey N-H Batterbee, Olivia D Chang, Abigael G Lucas, Jameson K Hirsch
This study examined loneliness and future orientation as predictors of suicidal risk, namely, depressive symptoms and suicide ideation, in a sample of 228 college students (54 males and 174 females). Results of regression analyses indicated that loneliness was a significant predictor of both indices of suicidal risk. The inclusion of future orientation was found to significantly augment the prediction model of both depressive symptoms and suicide ideation, even after accounting for loneliness. Noteworthy, beyond loneliness and future orientation, the Loneliness × Future Orientation interaction term was found to further augment both prediction models of suicidal risk...
May 9, 2017: Journal of Psychology
https://www.readbyqxmd.com/read/28483102/use-of-buprenorphine-in-treatment-of-refractory-depression-a-review-of-current-literature
#7
REVIEW
Cornel N Stanciu, Oliver M Glass, Thomas M Penders
OBJECTIVE: Current treatment strategies for depressive disorders have limited efficacy, leaving many patients unimproved or with significant residual symptoms. The development of additional treatments represent a significant unmet need for providers. Several lines of evidence suggest that the opioid system may be involved in regulation of mood and incentives salience. Intervention based on modifying central opioid receptors may represent a novel approach to treatment of depressive disorders among those unresponsive to accepted treatments...
April 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28481893/evaluation-of-a-transdiagnostic-psychodynamic-online-intervention-to-support-return-to-work-a-randomized-controlled-trial
#8
Rüdiger Zwerenz, Jan Becker, Katharina Gerzymisch, Martin Siepmann, Martin Holme, Ulrich Kiwus, Sieglinde Spörl-Dönch, Manfred E Beutel
OBJECTIVES: Given their flexibility, online interventions may be useful as an outpatient treatment option to support vocational reintegration after inpatient rehabilitation. To that purpose we devised a transdiagnostic psychodynamic online intervention to facilitate return to work, focusing on interpersonal conflicts at the workplace often responsible for work-related stress. RESEARCH DESIGN AND METHODS: In a randomized controlled trial, we included employed patients from cardiologic, psychosomatic and orthopedic rehabilitation with work-related stress or need for support at intake to inpatient rehabilitation after they had given written consent to take part in the study...
2017: PloS One
https://www.readbyqxmd.com/read/28476947/prenatal-ethanol-exposure-persistently-alters-endocannabinoid-signaling-and-endocannabinoid-mediated-excitatory-synaptic-plasticity-in-ventral-tegmental-area-dopamine-neurons
#9
Kathryn Hausknecht, Ying-Ling Shen, Rui-Xiang Wang, Samir Haj-Dahmane, Roh-Yu Shen
Prenatal ethanol exposure (PE) leads to increased addiction risk which could be mediated by enhanced excitatory synaptic strength in ventral tegmental area (VTA) dopamine (DA) neurons. Previous studies have shown that PE enhances excitatory synaptic strength by facilitating an anti-Hebbian form of long-term potentiation (LTP). In this study, we investigated the effect of PE on endocannabinoid-mediated long-term depression (eCB-LTD) in VTA DA neurons. Rats were exposed to moderate (3 g/kg/day) or high (6 g/kg/day) level of ethanol during gestation...
May 5, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28476920/clinically-styled-vagus-nerve-stimulation-augments-spontaneous-discharge-in-second-and-higher-order-sensory-neurons-in-rat-nucleus-of-the-solitary-tract
#10
Eric Beaumont, Regenia B Phillips Campbell, Michael C Andresen, Stephanie Lc Scofield, Krishna Singh, Imad Libbus, Bruce H KenKnight, Logan Snyder, Nathan Cantrell
Vagus nerve stimulation (VNS) currently treats patients with drug resistant epilepsy, depression and heart failure. The mild intensities used in chronic VNS suggest that primary visceral afferents and central nervous system activation are involved. Here we measured the activity of neurons in the nucleus of the solitary tract (NTS) in anesthetized rats using clinically-styled VNS. Our chief findings indicate that VNS at threshold bradycardic intensity activated NTS neuron discharge in one third of NTS neurons...
May 5, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28471479/internet-and-mobile-interventions-for-depression-opportunities-and-challenges
#11
REVIEW
Pim Cuijpers, Annet Kleiboer, Eirini Karyotaki, Heleen Riper
BACKGROUND: The Internet offers several new ways of developing, implementing, and disseminating evidence-based interventions for depression. METHODS: In this paper, we narratively synthesized the evidence showing that Internet-based therapies are effective in treating depression. RESULTS: In the past decade, a considerable number of psychological treatments have been developed for the treatment of depression and several hundreds of randomized controlled trials have been conducted, showing that these interventions are effective and that there are no major differences in effects between therapies...
May 4, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28468975/physiology-of-angina-and-its-alleviation-with-nitroglycerine-insights-from-invasive-catheter-laboratory-measurements-during-exercise
#12
Kaleab N Asrress, Rupert Williams, Timothy P Lockie, Muhammed Z Khawaja, Kalpa De Silva, Matthew Lumley, Tiffany Patterson, Satpal S Arri, Sana Ihsan, Howard Ellis, Antoine Guilcher, Brian R Clapp, Philip J Chowienczyk, Sven Plein, Divaka Perera, Michael Marber, Simon R Redwood
Background -The mechanisms governing exercise-induced angina and its alleviation by the most commonly used anti-anginal drug, nitroglycerine (GTN), are incompletely understood. The purpose of this study was to develop a method with which the effects of anti-anginal drugs could be evaluated invasively during physiological exercise to gain further understanding as to the clinical impact of angina and GTN. Methods -40 Patients (mean 65.2±7.6 years) with exertional angina and coronary artery disease underwent cardiac catheterisation via radial access and performed incremental exercise using a supine cycle ergometer...
May 3, 2017: Circulation
https://www.readbyqxmd.com/read/28468137/long-term-outcome-of-microautologous-fat-transplantation-to-correct-temporal-depression
#13
Su-Shin Lee, Yu-Hao Huang, Tsung-Yin Lin, Chih-Kang Chou, Hidenobu Takahashi, Chung-Sheng Lai, Sin-Daw Lin, Tsai-Ming Lin
OBJECTIVE: Sunken temporal fossa appears oftentimes in Asians and resembles bad fortune that people wish to change. Numerous techniques and materials have been applied clinically for augmenting the sunken temporal fossa with variable results. The microautologous fat transplantation (MAFT) technique proposed by Lin et al in 2006 has demonstrated favorable results in facial rejuvenation. In the present study, the authors applied the MAFT technique with an innovative instrument in sunken temporal fossa and reported its results...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28465612/incidence-worsening-and-risk-factors-of-daytime-sleepiness-in-a-population-based-5-year-longitudinal-study
#14
I Jaussent, C M Morin, H Ivers, Y Dauvilliers
Excessive daytime sleepiness (EDS) is highly prevalent in the general population; however little is known about its evolution and predictors. Our objectives were to document its natural history, provide estimates of its prevalence, incidence and persistence rates, and to identify predictors of increased daytime sleepiness (DS) in a longitudinal community study of 2157 adults over 5 years. Participants completed postal assessment at baseline and at each yearly follow-up. DS was evaluated by the Epworth Sleepiness scale (ESS)...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28445587/cb1-receptors-downregulate-a-camp-epac2-plc-pathway-to-silence-the-nerve-terminals-of-cerebellar-granule-cells
#15
Beatris Alonso, David Bartolomé-Martín, José Javier Ferrero, Jorge Ramírez-Franco, Magdalena Torres, José Sánchez-Prieto
Cannabinoid receptors mediate short-term retrograde inhibition of neurotransmitter release, as well as long-term depression of synaptic transmission at excitatory synapses. The responses of individual nerve terminals in VGLUT1-pHluorin transfected cerebellar granule cells to cannabinoids have shown that prolonged activation of cannabinoid type 1 receptors (CB1Rs) silences a subpopulation of previously active synaptic boutons. Adopting a combined pharmacological and genetic approach to study the molecular mechanisms of CB1R-induced silencing, we found that adenylyl cyclase inhibition decreases cAMP levels while it increases the number of silent synaptic boutons and occludes the induction of further silencing by the cannabinoid agonist HU-210...
April 26, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28444833/chronic-stress-induced-mechanical-hyperalgesia-is-controlled-by-capsaicin-sensitive-neurones-in-the-mouse
#16
B Scheich, P Vincze, É Szőke, É Borbély, Á Hunyady, J Szolcsányi, Á Dénes, Zs Környei, B Gaszner, Zs Helyes
BACKGROUND: Clinical studies demonstrated peripheral nociceptor deficit in stress-related chronic pain states, such as fibromyalgia. The interactions of stress and nociceptive systems have special relevance in chronic pain, but the underlying mechanisms including the role of specific nociceptor populations remain unknown. We investigated the role of capsaicin-sensitive neurones in chronic stress-related nociceptive changes. METHOD: Capsaicin-sensitive neurones were desensitized by the capsaicin analogue resiniferatoxin (RTX) in CD1 mice...
April 25, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28441583/randomized-controlled-trial-of-repetitive-transcranial-magnetic-stimulation-combined-with-paroxetine-for-the-treatment-of-patients-with-first-episode-major-depressive-disorder
#17
Yu-Mei Wang, Ning Li, Lin-Lin Yang, Mei Song, Le Shi, Wen-Hao Chen, Su-Xia Li, Xue-Yi Wang, Lin Lu
Repetitive transcranial magnetic stimulation (rTMS) has been introduced as a new and effective treatment option for major depression. This paper examined the effectiveness of rTMS on first episode depressed patients when combined with antidepressant drugs. A random sample of forty-three first-episode depressed patients received active or sham rTMS to the left dorsolateral prefrontal cortex, and concomitantly took paroxetine for 4 weeks, and paroxetine monotherapy for 4 weeks afterwards. Response was defined as a ≥50% decrease on the total Hamilton Depression Rating Scale (HDRS) from the baseline, and remission was defined as an HDRS total residual score <8...
April 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28436756/the-role-of-attachment-style-in-interpersonal-psychotherapy-for-depressed-adolescents
#18
Meredith Gunlicks-Stoessel, Ana Westervelt, Kristina Reigstad, Laura Mufson, Susanne Lee
OBJECTIVE(S): This study examined changes in depressed adolescents' reports of attachment anxiety and avoidance with interpersonal psychotherapy (IPT-A), and the relationship between attachment style and change in depression with IPT-A. METHOD: Forty adolescents (aged 12-17) participated in a 16-week randomized clinical trial of 4 adaptive treatment strategies for adolescent depression that began with IPT-A and augmented treatment for insufficient responders (n = 22) by adding additional IPT-A sessions (n = 11) or the antidepressant medication, fluoxetine (n = 11)...
April 24, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/28429472/transoral-orthodromic-temporalis-muscle-transfer-technique-for-the-paralysed-midface-our-learning-curve-experience-from-the-first-10-cases
#19
Lepa Lazarova, Tristram H Lesser, Samuel C Leong
Sir Harold Gillies first described rotating a band of temporalis muscle over the zygoma where the muscle sling was augmented with strips of fascia lata to rehabilitate facial paralysis (1) . McLaughlin later modified this technique in the 1950s without inversion of the temporal muscle but in an orthodromic manner thus avoiding the soft tissue fullness over the zygomatic arch area and depression of the donor site (2) . Although several refinements of this technique have been described, all required skin incisions on the face until a transoral technique was described recently by this clinical group (3) ...
April 21, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28418941/prenatal-fluoxetine-modifies-the-behavioral-and-hormonal-responses-to-stress-in-male-mice-role-for-glucocorticoid-insensitivity
#20
Ronit Avitsur
Women with major depressive disorder during pregnancy often use selective serotonin reuptake inhibitors (SSRIs) antidepressants. These drugs readily cross the placental barrier and impact the developing fetal brain. Recently, we reported that prenatal fluoxetine (FLX), an SSRI antidepressant drug, altered corticosterone and behavioral responses to stress in female mouse offspring. The present study assessed the effects of prenatal FLX on these responses in males. The results showed that prenatal FLX significantly augmented the corticosterone response to acute stress in young prepubescent mice...
April 17, 2017: Behavioural Pharmacology
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