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https://www.readbyqxmd.com/read/27746700/effects-of-maternal-symptom-ratings-and-other-clinical-features-on-short-term-treatment-response-to-oros-methylphenidate-in-children-and-adolescents-with-adhd-in-a-naturalistic-clinical-setting
#1
Esra Cop Tasgin, Ozgur Oner, Pinar Yurtbasi, Kerim Munir
OBJECTIVE: To investigate the effect of Attention Deficit Hyperactivity Disorder (ADHD), antisocial behavior and anxiety/depression ratings of mothers, and child and adolescents' age, gender, ADHD subtype, and comorbidity on one-month drug treatment response to OROS methylphenidate in ADHD in a naturalistic setting. METHODS: The analyses included 223 subjects (191 boys, 32 girls; age 6-15 years, mean: 9.4) treated with OROS methylphenidate (18-72 mg/day, mean: 31 mg/d; 0...
2016: Bulletin of Clinical Psychopharmacology [Klinik Psikofarmakoloji Bülteni]
https://www.readbyqxmd.com/read/27238065/severely-aggressive-children-receiving-stimulant-medication-versus-stimulant-and-risperidone-12-month-follow-up-of-the-tosca-trial
#2
Kenneth D Gadow, Nicole V Brown, L Eugene Arnold, Kristin A Buchan-Page, Oscar G Bukstein, Eric Butter, Cristan A Farmer, Robert L Findling, David J Kolko, Brooke S G Molina, Robert R Rice, Jayne Schneider, Michael G Aman
OBJECTIVE: The objective of this study was to evaluate 52-week clinical outcomes of children with co-occurring attention-deficit/hyperactivity disorder (ADHD), disruptive behavior disorder, and serious physical aggression who participated in a prospective, longitudinal study that began with a controlled, 9-week clinical trial comparing the relative efficacy of parent training + stimulant medication + placebo (Basic; n = 84) versus parent training + stimulant + risperidone (Augmented; n = 84)...
June 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27186140/single-exposure-of-dopamine-d1-antagonist-prevents-and-d2-antagonist-attenuates-methylphenidate-effect
#3
Catherine M Claussen, Lindsey J Witte, Nachum Dafny
Methylphenidate (MPD) is a readily prescribed drug for the treatment of attention deficit hyperactivity disorder (ADHD) and moreover is used illicitly by youths for its cognitive-enhancing effects and recreation. MPD exposure in rodents elicits increased locomotor activity. Repetitive MPD exposure leads to further augmentation of their locomotor activity. This behavioral response is referred to as behavioral sensitization. Behavioral sensitization is used as an experimental marker for a drug's ability to elicit dependence...
2015: Journal of Experimental Pharmacology
https://www.readbyqxmd.com/read/27117555/the-children-s-attention-deficit-hyperactivity-disorder-telemental-health-treatment-study-caregiver-outcomes
#4
Ann Vander Stoep, Carolyn A McCarty, Chuan Zhou, Carol M Rockhill, Erin N Schoenfelder, Kathleen Myers
The Children's Attention-deficit Hyperactivity Disorder (ADHD) Telemental Health Treatment Study (CATTS) tested the hypotheses that children and caregivers who received guideline-based treatment delivered through a hybrid telehealth service delivery model would experience greater improvements in outcomes than children and caregivers receiving treatment via a comparison delivery model. Here, we present caregiver outcomes. 88 primary care providers (PCPs) in seven geographically underserved communities referred 223 children (ages 5...
April 27, 2016: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/27087081/attenuation-of-methylphenidate-induced-sensitization-by-co-administration-of-buspirone
#5
Nausheen Alam, Rahila Najam, Sadaf Naeem
Methylphenidate, which inhibit dopamine transporter is effective in the treatment of ADHD (attention deficit hyperactivity disorder), but long term use of this drug is often associated with addiction and dependence. Locomotor sensitization development to psychostimulants like methylphenidate is an important contributor to drug abuse induced by psychostimulants. Different studies have shown that long term administration of drugs of abuse increases the effectiveness of 5-hydroxytryptamine (5-HT)-1A somatodendritic receptors...
March 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27009498/developing-mhealth-remote-monitoring-technology-for-attention-deficit-hyperactivity-disorder-a-qualitative-study-eliciting-user-priorities-and-needs
#6
Lucy Simons, Althea Z Valentine, Caroline J Falconer, Madeleine Groom, David Daley, Michael P Craven, Zoe Young, Charlotte Hall, Chris Hollis
BACKGROUND: Guidelines in the United Kingdom recommend that medication titration for attention deficit hyperactivity disorder (ADHD) should be completed within 4-6 weeks and include regular reviews. However, most clinicians think that weekly clinic contact is infeasible, and audits have shown that this timeline is rarely achieved. Thus, a more effective monitoring and review system is needed; remote monitoring technology (RMT) may be one way to improve current practice. However, little is known about whether patients with ADHD, their families, and clinicians would be interested in using RMT...
2016: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/27007844/thalamic-reticular-impairment-underlies-attention-deficit-in-ptchd1-y-mice
#7
Michael F Wells, Ralf D Wimmer, L Ian Schmitt, Guoping Feng, Michael M Halassa
Developmental disabilities, including attention-deficit hyperactivity disorder (ADHD), intellectual disability (ID), and autism spectrum disorders (ASD), affect one in six children in the USA. Recently, gene mutations in patched domain containing 1 (PTCHD1) have been found in ~1% of patients with ID and ASD. Individuals with PTCHD1 deletion show symptoms of ADHD, sleep disruption, hypotonia, aggression, ASD, and ID. Although PTCHD1 is probably critical for normal development, the connection between its deletion and the ensuing behavioural defects is poorly understood...
April 7, 2016: Nature
https://www.readbyqxmd.com/read/26740931/does-mindfulness-meditation-improve-attention-in-attention-deficit-hyperactivity-disorder
#8
REVIEW
Vania Modesto-Lowe, Pantea Farahmand, Margaret Chaplin, Lauren Sarro
Attention deficit hyperactivity disorder (ADHD) manifests by high levels of inattention, impulsiveness and hyperactivity. ADHD starts in childhood and results in impairments that continue into adulthood. While hyperactivity declines over time, inattention and executive function difficulties persist, leading to functional deficits. Adolescents and adults with ADHD have pervasive impairment in interpersonal and family relationships. They may develop addiction, delinquent behavior and comorbid psychiatric disorders...
December 22, 2015: World Journal of Psychiatry
https://www.readbyqxmd.com/read/26598594/atomoxetine-augmentation-in-a-case-of-treatment-resistant-panic-disorder-with-multiple-augments-failure-a-case-report
#9
Dushad Ram, Shwetha Patil, Basavana Gowdappa, Iyshwarya Rajalakshmi
Atomoxetine, a selective norepinephrine inhibitor, is effective in comorbid anxiety and attention deficit hyperactivity disorder, however its role in panic disorder is unknown. We are presenting a case of panic disorder, who initially partially responded to clonazepam. When clonazepam was added with sertraline, escitalopram, desvenlafaxin, she did not improve significantly until paroxetine was added. When clonazepam-paroxetine combination was added with propranolol, etizolam, olanzepine, risperidone and amisulpride the symptom remission did not occur until a trial of Atomoxetine was done...
December 31, 2015: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26529542/interaction-between-methylphenidate-methadone-and-different-antidepressant-drugs-on-antinociception-in-mice-and-possible-clinical-implications
#10
Shaul Schreiber, Miaad Bader, Vardit Rubovitch, Chaim G Pick
OBJECTIVES: Methylphenidate (MPH), a psychostimulant used for treatment of attention deficit hyperactivity disorder (ADHD), is widely used by patients on antidepressants and methadone maintenance treatment (MMT). Preclinical studies showed MPH to exert analgesic effects when given alone or with morphine. METHODS: Using the hotplate assay on mice, we studied the interaction of acute doses of MPH with sub-threshold doses of methadone and different antidepressant medications and the interaction of increasing doses of MPH with chronic methadone...
November 3, 2015: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/26429338/telepsychiatry-intervention-is-better-for-adhd-symptoms-than-usual-treatment-augmented-by-telemedicine-consultation
#11
COMMENT
Carol Rockhill
No abstract text is available yet for this article.
November 2015: Evidence-based Mental Health
https://www.readbyqxmd.com/read/26363140/the-executive-control-network-and-symptomatic-improvement-in-attention-deficit-hyperactivity-disorder
#12
Winke Francx, Marianne Oldehinkel, Jaap Oosterlaan, Dirk Heslenfeld, Catharina A Hartman, Pieter J Hoekstra, Barbara Franke, Christian F Beckmann, Jan K Buitelaar, Maarten Mennes
BACKGROUND: One neurodevelopmental theory hypothesizes remission of attention-deficit/hyperactivity disorder (ADHD) to result from improved prefrontal top-down control, while ADHD, independent of the current diagnosis, is characterized by stable non-cortical deficits (Halperin & Schulz, 2006). We tested this theory using resting state functional MRI (fMRI) data in a large sample of adolescents with remitting ADHD, persistent ADHD, and healthy controls. METHODS: Participants in this follow-up study were 100 healthy controls and 129 adolescents with ADHD combined type at baseline (mean age at baseline 11...
December 2015: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/26321911/slow-oscillating-transcranial-direct-current-stimulation-during-non-rapid-eye-movement-sleep-improves-behavioral-inhibition-in-attention-deficit-hyperactivity-disorder
#13
Manuel T Munz, Alexander Prehn-Kristensen, Frederieke Thielking, Matthias Mölle, Robert Göder, Lioba Baving
BACKGROUND: Behavioral inhibition, which is a later-developing executive function (EF) and anatomically located in prefrontal areas, is impaired in attention-deficit and hyperactivity disorder (ADHD). While optimal EFs have been shown to depend on efficient sleep in healthy subjects, the impact of sleep problems, frequently reported in ADHD, remains elusive. Findings of macroscopic sleep changes in ADHD are inconsistent, but there is emerging evidence for distinct microscopic changes with a focus on prefrontal cortical regions and non-rapid eye movement (non-REM) slow-wave sleep...
2015: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/26258927/telepsychiatrists-medication-treatment-strategies-in-the-children-s-attention-deficit-hyperactivity-disorder-telemental-health-treatment-study
#14
Carol M Rockhill, Yuet Juhn Tse, Megan D Fesinmeyer, Jessica Garcia, Kathleen Myers
OBJECTIVE: The purpose of this study was to examine the prescribing strategies that telepsychiatrists used to provide pharmacologic treatment in the Children's Attention-Deficit/Hyperactivity Disorder (ADHD) Telemental Health Treatment Study (CATTS). METHODS: CATTS was a randomized controlled trial that demonstrated the superiority of a telehealth service delivery model for the treatment of ADHD with combined pharmacotherapy and behavior training (n=111), compared with management in primary care augmented with a telepsychiatry consultation (n=112)...
October 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/26246793/treatment-refractory-anxiety-definition-risk-factors-and-treatment-challenges
#15
REVIEW
Peter Roy-Byrne
A sizable proportion of psychiatric patients will seek clinical evaluation and treatment for anxiety symptoms reportedly refractory to treatment. This apparent lack of response is either due to "pseudo-resistance" (a failure to have received and adhered to a recognized and effective treatment or treatments for their condition) or to true "treatment resistance." Pseudo-resistance can be due to clinician errors in selecting and delivering an appropriate treatment effectively, or to patient nonadherence to a course of treatment...
June 2015: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/26216249/variation-in-parasympathetic-dysregulation-moderates-short-term-memory-problems-in-childhood-attention-deficit-hyperactivity-disorder
#16
Anthony R Ward, Gabriela Alarcón, Joel T Nigg, Erica D Musser
Although attention deficit/hyperactivity disorder (ADHD) is associated with impairment in working memory and short-term memory, up to half of individual children with ADHD perform within a normative range. Heterogeneity in other ADHD-related mechanisms, which may compensate for or combine with cognitive weaknesses, is a likely explanation. One candidate is the robustness of parasympathetic regulation (as indexed by respiratory sinus arrhythmia; RSA). Theory and data suggest that a common neural network is likely tied to both heart-rate regulation and certain cognitive functions (including aspects of working and short-term memory)...
November 2015: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/26149510/long-qt-syndrome-and-therapy-for-attention-deficit-hyperactivity-disorder
#17
RANDOMIZED CONTROLLED TRIAL
Claire Zhang, Valentina Kutyifa, Arthur J Moss, Scott McNitt, Wojciech Zareba, Elizabeth S Kaufman
INTRODUCTION: Stimulants are the mainstay therapy for attention deficit/hyperactivity disorder (ADHD) and are associated with adrenergic side effects. There are limited data on the clinical course of patients treated for ADHD who have long-QT syndrome (LQTS), for which β-blockade is the goal of therapy. METHODS: LQTS patients from the Rochester-based LQTS Registry (open-enrollment between 1979 and 2003; follow-up from 1979 to present) treated with stimulant or nonstimulant ADHD medications (n = 48) were compared to a 2:1 age-, gender-, and QTc-duration matched LQTS control group not exposed to ADHD medications (n = 96)...
October 2015: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/26148950/pediatric-psychopharmacology-for-treatment-of-adhd-depression-and-anxiety
#18
REVIEW
Cathy Southammakosane, Kristine Schmitz
The pediatric practitioner is often the first point-of-contact for children and adolescents suffering from mental illness. Part of the treatment planning for psychiatric diagnoses includes consideration of medication. Attention-deficit/hyperactivity disorder, one of the most common diagnoses, is very responsive to stimulant medications; for children who are unable to tolerate stimulants or who do not achieve satisfactory symptom management, central α-agonists and atomoxetine are effective and generally well-tolerated alternative or augmentative agents...
August 2015: Pediatrics
https://www.readbyqxmd.com/read/25885012/participant-satisfaction-in-a-study-of-stimulant-parent-training-and-risperidone-in-children-with-severe-physical-aggression
#19
RANDOMIZED CONTROLLED TRIAL
E Victoria Rundberg-Rivera, Lisa D Townsend, Jayne Schneider, Cristan A Farmer, Brooke B S G Molina, Robert L Findling, Kenneth D Gadow, Oscar G Bukstein, L Eugene Arnold, David J Kolko, Kristin A Buchan-Page, Nora K McNamara, Chenel Michel, Adrienne Austin, Heidi Kipp, Robert R Rice, Michael G Aman
OBJECTIVE: The purpose of this study was to examine the satisfaction of families who participated in the Treatment of Severe Childhood Aggression (TOSCA) study. METHODS: TOSCA was a randomized clinical trial of psychostimulant plus parent training plus placebo (basic treatment) versus psychostimulant plus parent training plus risperidone (augmented treatment) for children with severe physical aggression, disruptive behavior disorder, and attention-deficit/hyperactivity disorder...
April 2015: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/25885011/comorbid-symptomatology-moderates-response-to-risperidone-stimulant-and-parent-training-in-children-with-severe-aggression-disruptive-behavior-disorder-and-attention-deficit-hyperactivity-disorder
#20
RANDOMIZED CONTROLLED TRIAL
Cristan A Farmer, Nicole V Brown, Kenneth D Gadow, L Eugene Arnold, David G Kolko, Robert L Findling, Brooke S G Molina, Kristin A Buchan-Page, Robert R Rice, Srihari S Bangalore, Oscar Bukstein, E Victoria Rundberg-Rivera, Nora McNamara, Michael G Aman
OBJECTIVE: In this study, we evaluated parent and child characteristics as predictors and moderators of response in the four-site Treatment of Severe Childhood Aggression (TOSCA) study. METHODS: A total of 168 children with severe aggression, disruptive behavior disorder, and attention-deficit/hyperactivity disorder (ADHD) were enrolled in a 9-week trial of basic treatment (n=84, stimulant+parent training+placebo) versus augmented treatment (n=84, stimulant+parent training+risperidone)...
April 2015: Journal of Child and Adolescent Psychopharmacology
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