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https://www.readbyqxmd.com/read/28212067/the-treatment-of-severe-childhood-aggression-study-12-weeks-of-extended-blinded-treatment-in-clinical-responders
#1
Robert L Findling, Lisa Townsend, Nicole V Brown, L Eugene Arnold, Kenneth D Gadow, David J Kolko, Nora K McNamara, Devin S Gary, Dana B Kaplin, Cristan A Farmer, Heidi Kipp, Craig Williams, Eric M Butter, Oscar G Bukstein, Robert Rice, Kristin Buchan-Page, Brooke S G Molina, Michael G Aman
OBJECTIVES: Previous "Treatment of Severe Childhood Aggression" (TOSCA) reports demonstrated that many children with severe physical aggression and attention-deficit/hyperactivity disorder (ADHD) responded well to two randomized treatments (parent training [PT]+stimulant+placebo = Basic vs. PT+stimulant+risperidone = Augmented) for 9 weeks. An important clinical question is whether these favorable outcomes are maintained over longer times. METHODS: Clinical responders to the 9-week trial (n = 103/168), defined as Clinical Global Impressions (CGI)-Improvement of much/very much improved plus substantial reduction in parent ratings of disruptiveness, were followed another 12 weeks (21 weeks total) while remaining on blinded treatment...
February 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28118752/the-impact-of-adjunctive-guanfacine-extended-release-on-stimulant-adherence-in-children-adolescents-with-attention-deficit-hyperactivity-disorder
#2
Juliana Meyers, Kavita Gajria, Sean D Candrilli, Moshe Fridman, Vanja Sikirica
AIM: To assess stimulant adherence among children/adolescents with attention-deficit/hyperactivity disorder (ADHD) augmenting stimulants with guanfacine extended-release (GXR). PATIENTS & METHODS: Inclusion criteria: 6-17 years, ≥1 ADHD diagnosis, ≥1 long-acting and/or short-acting stimulant with GXR augmentation. Modified medication possession ratio (mMPR; days medication available/days in period, excluding medication holidays) was assessed; mMPR < 0.80 nonadherent...
25, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28065167/diagnostic-utility-of-brain-activity-flow-patterns-analysis-in-attention-deficit-hyperactivity-disorder
#3
J Biederman, P Hammerness, B Sadeh, Z Peremen, A Amit, H Or-Ly, Y Stern, A Reches, A Geva, S V Faraone
BACKGROUND: A previous small study suggested that Brain Network Activation (BNA), a novel ERP-based brain network analysis, may have diagnostic utility in attention deficit hyperactivity disorder (ADHD). In this study we examined the diagnostic capability of a new advanced version of the BNA methodology on a larger population of adults with and without ADHD. METHOD: Subjects were unmedicated right-handed 18- to 55-year-old adults of both sexes with and without a DSM-IV diagnosis of ADHD...
January 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28033486/adhd-and-temporality-a-desynchronized-way-of-being-in-the-world
#4
Mikka Nielsen
ADHD is, I argue, an impairment in sense of time and a matter of difference in rhythm; it can be understood as a certain being in the world, or more specifically, as a disruption in the experience of time and a state of desynchronization and arrhythmia. Through excerpts of interviews with adults diagnosed with ADHD and observations, I illustrate how impairment in time is manifested in an embodied experience of being out of sync. I suggest that the experience of ADHD is characterized as 1) an inner restlessness and bodily arrhythmia; 2) an intersubjective desynchronization between the individual and its surroundings; and 3) a feeling of lagging behind socially due to difficulties in social skills...
December 29, 2016: Medical Anthropology
https://www.readbyqxmd.com/read/27746700/effects-of-maternal-symptom-ratings-and-other-clinical-features-on-short-term-treatment-response-to-oros-methylphenidate-in-children-and-adolescents-with-adhd-in-a-naturalistic-clinical-setting
#5
Esra Cop Tasgin, Ozgur Oner, Pinar Yurtbasi, Kerim Munir
OBJECTIVE: To investigate the effect of Attention Deficit Hyperactivity Disorder (ADHD), antisocial behavior and anxiety/depression ratings of mothers, and child and adolescents' age, gender, ADHD subtype, and comorbidity on one-month drug treatment response to OROS methylphenidate in ADHD in a naturalistic setting. METHODS: The analyses included 223 subjects (191 boys, 32 girls; age 6-15 years, mean: 9.4) treated with OROS methylphenidate (18-72 mg/day, mean: 31 mg/d; 0...
2016: Bulletin of Clinical Psychopharmacology [Klinik Psikofarmakoloji Bülteni]
https://www.readbyqxmd.com/read/27238065/severely-aggressive-children-receiving-stimulant-medication-versus-stimulant-and-risperidone-12-month-follow-up-of-the-tosca-trial
#6
Kenneth D Gadow, Nicole V Brown, L Eugene Arnold, Kristin A Buchan-Page, Oscar G Bukstein, Eric Butter, Cristan A Farmer, Robert L Findling, David J Kolko, Brooke S G Molina, Robert R Rice, Jayne Schneider, Michael G Aman
OBJECTIVE: The objective of this study was to evaluate 52-week clinical outcomes of children with co-occurring attention-deficit/hyperactivity disorder (ADHD), disruptive behavior disorder, and serious physical aggression who participated in a prospective, longitudinal study that began with a controlled, 9-week clinical trial comparing the relative efficacy of parent training + stimulant medication + placebo (Basic; n = 84) versus parent training + stimulant + risperidone (Augmented; n = 84)...
June 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27186140/single-exposure-of-dopamine-d1-antagonist-prevents-and-d2-antagonist-attenuates-methylphenidate-effect
#7
Catherine M Claussen, Lindsey J Witte, Nachum Dafny
Methylphenidate (MPD) is a readily prescribed drug for the treatment of attention deficit hyperactivity disorder (ADHD) and moreover is used illicitly by youths for its cognitive-enhancing effects and recreation. MPD exposure in rodents elicits increased locomotor activity. Repetitive MPD exposure leads to further augmentation of their locomotor activity. This behavioral response is referred to as behavioral sensitization. Behavioral sensitization is used as an experimental marker for a drug's ability to elicit dependence...
2015: Journal of Experimental Pharmacology
https://www.readbyqxmd.com/read/27117555/the-children-s-attention-deficit-hyperactivity-disorder-telemental-health-treatment-study-caregiver-outcomes
#8
Ann Vander Stoep, Carolyn A McCarty, Chuan Zhou, Carol M Rockhill, Erin N Schoenfelder, Kathleen Myers
The Children's Attention-deficit Hyperactivity Disorder (ADHD) Telemental Health Treatment Study (CATTS) tested the hypotheses that children and caregivers who received guideline-based treatment delivered through a hybrid telehealth service delivery model would experience greater improvements in outcomes than children and caregivers receiving treatment via a comparison delivery model. Here, we present caregiver outcomes. 88 primary care providers (PCPs) in seven geographically underserved communities referred 223 children (ages 5...
January 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/27087081/attenuation-of-methylphenidate-induced-sensitization-by-co-administration-of-buspirone
#9
Nausheen Alam, Rahila Najam, Sadaf Naeem
Methylphenidate, which inhibit dopamine transporter is effective in the treatment of ADHD (attention deficit hyperactivity disorder), but long term use of this drug is often associated with addiction and dependence. Locomotor sensitization development to psychostimulants like methylphenidate is an important contributor to drug abuse induced by psychostimulants. Different studies have shown that long term administration of drugs of abuse increases the effectiveness of 5-hydroxytryptamine (5-HT)-1A somatodendritic receptors...
March 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27009498/developing-mhealth-remote-monitoring-technology-for-attention-deficit-hyperactivity-disorder-a-qualitative-study-eliciting-user-priorities-and-needs
#10
Lucy Simons, Althea Z Valentine, Caroline J Falconer, Madeleine Groom, David Daley, Michael P Craven, Zoe Young, Charlotte Hall, Chris Hollis
BACKGROUND: Guidelines in the United Kingdom recommend that medication titration for attention deficit hyperactivity disorder (ADHD) should be completed within 4-6 weeks and include regular reviews. However, most clinicians think that weekly clinic contact is infeasible, and audits have shown that this timeline is rarely achieved. Thus, a more effective monitoring and review system is needed; remote monitoring technology (RMT) may be one way to improve current practice. However, little is known about whether patients with ADHD, their families, and clinicians would be interested in using RMT...
2016: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/27007844/thalamic-reticular-impairment-underlies-attention-deficit-in-ptchd1-y-mice
#11
Michael F Wells, Ralf D Wimmer, L Ian Schmitt, Guoping Feng, Michael M Halassa
Developmental disabilities, including attention-deficit hyperactivity disorder (ADHD), intellectual disability (ID), and autism spectrum disorders (ASD), affect one in six children in the USA. Recently, gene mutations in patched domain containing 1 (PTCHD1) have been found in ~1% of patients with ID and ASD. Individuals with PTCHD1 deletion show symptoms of ADHD, sleep disruption, hypotonia, aggression, ASD, and ID. Although PTCHD1 is probably critical for normal development, the connection between its deletion and the ensuing behavioural defects is poorly understood...
April 7, 2016: Nature
https://www.readbyqxmd.com/read/26740931/does-mindfulness-meditation-improve-attention-in-attention-deficit-hyperactivity-disorder
#12
REVIEW
Vania Modesto-Lowe, Pantea Farahmand, Margaret Chaplin, Lauren Sarro
Attention deficit hyperactivity disorder (ADHD) manifests by high levels of inattention, impulsiveness and hyperactivity. ADHD starts in childhood and results in impairments that continue into adulthood. While hyperactivity declines over time, inattention and executive function difficulties persist, leading to functional deficits. Adolescents and adults with ADHD have pervasive impairment in interpersonal and family relationships. They may develop addiction, delinquent behavior and comorbid psychiatric disorders...
December 22, 2015: World Journal of Psychiatry
https://www.readbyqxmd.com/read/26598594/atomoxetine-augmentation-in-a-case-of-treatment-resistant-panic-disorder-with-multiple-augments-failure-a-case-report
#13
Dushad Ram, Shwetha Patil, Basavana Gowdappa, Iyshwarya Rajalakshmi
Atomoxetine, a selective norepinephrine inhibitor, is effective in comorbid anxiety and attention deficit hyperactivity disorder, however its role in panic disorder is unknown. We are presenting a case of panic disorder, who initially partially responded to clonazepam. When clonazepam was added with sertraline, escitalopram, desvenlafaxin, she did not improve significantly until paroxetine was added. When clonazepam-paroxetine combination was added with propranolol, etizolam, olanzepine, risperidone and amisulpride the symptom remission did not occur until a trial of Atomoxetine was done...
December 31, 2015: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26529542/interaction-between-methylphenidate-methadone-and-different-antidepressant-drugs-on-antinociception-in-mice-and-possible-clinical-implications
#14
Shaul Schreiber, Miaad Bader, Vardit Rubovitch, Chaim G Pick
OBJECTIVES: Methylphenidate (MPH), a psychostimulant used for treatment of attention deficit hyperactivity disorder (ADHD), is widely used by patients on antidepressants and methadone maintenance treatment (MMT). Preclinical studies showed MPH to exert analgesic effects when given alone or with morphine. METHODS: Using the hotplate assay on mice, we studied the interaction of acute doses of MPH with sub-threshold doses of methadone and different antidepressant medications and the interaction of increasing doses of MPH with chronic methadone...
November 3, 2015: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/26429338/telepsychiatry-intervention-is-better-for-adhd-symptoms-than-usual-treatment-augmented-by-telemedicine-consultation
#15
COMMENT
Carol Rockhill
No abstract text is available yet for this article.
November 2015: Evidence-based Mental Health
https://www.readbyqxmd.com/read/26363140/the-executive-control-network-and-symptomatic-improvement-in-attention-deficit-hyperactivity-disorder
#16
Winke Francx, Marianne Oldehinkel, Jaap Oosterlaan, Dirk Heslenfeld, Catharina A Hartman, Pieter J Hoekstra, Barbara Franke, Christian F Beckmann, Jan K Buitelaar, Maarten Mennes
BACKGROUND: One neurodevelopmental theory hypothesizes remission of attention-deficit/hyperactivity disorder (ADHD) to result from improved prefrontal top-down control, while ADHD, independent of the current diagnosis, is characterized by stable non-cortical deficits (Halperin & Schulz, 2006). We tested this theory using resting state functional MRI (fMRI) data in a large sample of adolescents with remitting ADHD, persistent ADHD, and healthy controls. METHODS: Participants in this follow-up study were 100 healthy controls and 129 adolescents with ADHD combined type at baseline (mean age at baseline 11...
December 2015: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/26321911/slow-oscillating-transcranial-direct-current-stimulation-during-non-rapid-eye-movement-sleep-improves-behavioral-inhibition-in-attention-deficit-hyperactivity-disorder
#17
Manuel T Munz, Alexander Prehn-Kristensen, Frederieke Thielking, Matthias Mölle, Robert Göder, Lioba Baving
BACKGROUND: Behavioral inhibition, which is a later-developing executive function (EF) and anatomically located in prefrontal areas, is impaired in attention-deficit and hyperactivity disorder (ADHD). While optimal EFs have been shown to depend on efficient sleep in healthy subjects, the impact of sleep problems, frequently reported in ADHD, remains elusive. Findings of macroscopic sleep changes in ADHD are inconsistent, but there is emerging evidence for distinct microscopic changes with a focus on prefrontal cortical regions and non-rapid eye movement (non-REM) slow-wave sleep...
2015: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/26258927/telepsychiatrists-medication-treatment-strategies-in-the-children-s-attention-deficit-hyperactivity-disorder-telemental-health-treatment-study
#18
Carol M Rockhill, Yuet Juhn Tse, Megan D Fesinmeyer, Jessica Garcia, Kathleen Myers
OBJECTIVE: The purpose of this study was to examine the prescribing strategies that telepsychiatrists used to provide pharmacologic treatment in the Children's Attention-Deficit/Hyperactivity Disorder (ADHD) Telemental Health Treatment Study (CATTS). METHODS: CATTS was a randomized controlled trial that demonstrated the superiority of a telehealth service delivery model for the treatment of ADHD with combined pharmacotherapy and behavior training (n=111), compared with management in primary care augmented with a telepsychiatry consultation (n=112)...
October 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/26246793/treatment-refractory-anxiety-definition-risk-factors-and-treatment-challenges
#19
REVIEW
Peter Roy-Byrne
A sizable proportion of psychiatric patients will seek clinical evaluation and treatment for anxiety symptoms reportedly refractory to treatment. This apparent lack of response is either due to "pseudo-resistance" (a failure to have received and adhered to a recognized and effective treatment or treatments for their condition) or to true "treatment resistance." Pseudo-resistance can be due to clinician errors in selecting and delivering an appropriate treatment effectively, or to patient nonadherence to a course of treatment...
June 2015: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/26216249/variation-in-parasympathetic-dysregulation-moderates-short-term-memory-problems-in-childhood-attention-deficit-hyperactivity-disorder
#20
Anthony R Ward, Gabriela Alarcón, Joel T Nigg, Erica D Musser
Although attention deficit/hyperactivity disorder (ADHD) is associated with impairment in working memory and short-term memory, up to half of individual children with ADHD perform within a normative range. Heterogeneity in other ADHD-related mechanisms, which may compensate for or combine with cognitive weaknesses, is a likely explanation. One candidate is the robustness of parasympathetic regulation (as indexed by respiratory sinus arrhythmia; RSA). Theory and data suggest that a common neural network is likely tied to both heart-rate regulation and certain cognitive functions (including aspects of working and short-term memory)...
November 2015: Journal of Abnormal Child Psychology
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