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Bone allograft

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https://www.readbyqxmd.com/read/28429555/management-of-mineral-and-bone-disorders-in-renal-transplant-recipients
#1
Matthew J Damasiewicz, Peter R Ebeling
The management of post-transplantation bone disease is a complex problem that remains under-appreciated in clinical practice. In these patients, pre-existing metabolic bone disorder is further impacted by the use of immunosuppressive medications (glucocorticoids and calcineurin-inhibitors), variable post-transplantation renal allograft function and post-transplantation diabetes mellitus. The treatment of post-transplantation bone loss should begin pre-transplantation. All patients active on transplant waiting lists should be screened for bone disease...
March 2017: Nephrology
https://www.readbyqxmd.com/read/28428609/socket-preservation
#2
L Fee
Socket preservation maintains bone volume post-extraction in anticipation of an implant placement or fixed partial denture pontic site. This procedure helps compensate for the resorption of the facial bone wall. Socket preservation should be considered when implant placement needs to be delayed for patient or site-related reasons. The ideal healing time before implant placement is six months. Socket preservation can reduce the need for later bone augmentation. By reducing bone resorption and accelerating bone formation it increases implant success and survival...
April 21, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28419816/high-rate-of-osteoarthritis-after-osteochondritis-dissecans-fragment-excision-compared-with-surgical-restoration-at-a-mean-16-year-follow-up
#3
Thomas L Sanders, Ayoosh Pareek, Mitchel R Obey, Nicholas R Johnson, James L Carey, Michael J Stuart, Aaron J Krych
BACKGROUND: Osteochondritis dissecans (OCD) is a disorder of subchondral bone that causes adverse effects on the overlying cartilage and commonly affects the knee. The incidence of OCD and its long-term effect on the knee joint are controversial. Hypothesis/Purpose: The purpose of this study was to (1) evaluate the rate of osteoarthritis and knee arthroplasty in a population-based cohort of patients with OCD lesions treated operatively and (2) evaluate factors that may predispose patients to knee osteoarthritis and arthroplasty...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28419808/outcomes-after-1-stage-versus-2-stage-revision-anterior-cruciate-ligament-reconstruction
#4
Justin J Mitchell, Jorge Chahla, Chase S Dean, Mark Cinque, Lauren M Matheny, Robert F LaPrade
BACKGROUND: Revision anterior cruciate ligament reconstruction (ACLR) is becoming increasingly common as the number of primary ACLR cases continues to rise. Despite this, there are limited data on the outcomes of revision ACLR and even less information specifically addressing the differences in 1-stage revision reconstruction versus those performed in a 2-stage fashion after primary reconstruction. PURPOSE: To compare the outcomes, patient satisfaction, and failure rates of 1-stage versus 2-stage revision ACLR...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28418278/the-effect-of-surgical-insertion-and-proinflammatory-cytokines-on-osteochondral-allograft-survival-and-metabolism
#5
Samantha L Gitelis, Ariel Bodker, Michel P Laurent, Spencer S Kirk, Giuseppe Filardo, Maximilian A Meyer, Arnavaz A Hakimiyan, Lev Rappoport, Markus A Wimmer, Brian J Cole, Susan Chubinskaya
Objective To investigate the responses of refrigerated osteochondral allograft cartilage (OCA) and fresh cartilage (FC), including cell survival and metabolism, to surgical impaction and proinflammatory cytokines. Design Osteochondral plugs (8 mm diameter) were harvested from prolonged-refrigerated (14-28 days) and fresh (≤24 hours postmortem) human femoral hemicondyles and subjected to a 0.2 N s pneumatic impaction impulse. Cartilage explants were removed from subchondral bone and randomized to 1 of 6 treatment groups: (1) Unimpacted control (UIC), (2) Impacted control (IC), (3) Impacted + interleukin (IL)-1β (0...
January 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28416462/clinical-assessment-of-115-cases-of-hindfoot-fusion-with-two-different-types-of-graft-allograft-dbm-bone-marrow-aspirate-versus-autograft-dbm
#6
Mathias Tricot, Paul-André Deleu, Christine Detrembleur, Thibaut Leemrijse
INTRODUCTION: Nonunion is a common complication (15%) of hindfoot and ankle arthrodesis. Autograft can improve the fusion rate because of its osteoconductive, osteoinductive and osteogenic properties. However, autograft harvesting is a source of morbidity. One alternative is to combine allograft with demineralized bone matrix (DBM) and iliac bone marrow aspirate (BMA). This combination graft has similar biological properties to healthy bone. When used alone, allograft has osteoconductive and sometimes structural properties...
April 14, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28408254/midterm-outcomes-of-bone-grafting-in-glenoid-defects-treated-with-reverse-shoulder-arthroplasty
#7
Yaiza Lopiz, Carlos García-Fernández, Alvaro Arriaza, Belen Rizo, Hector Marcelo, Fernando Marco
BACKGROUND: Large glenoid defects are a difficult reconstructive problem for shoulder surgeons. The purpose of this study was to determine the complications, rate of healing, and functional results of glenoid bone grafting in primary or revision surgery with reverse shoulder arthroplasty. METHODS: We retrospectively reviewed 23 patients with glenoid bone loss who underwent primary or revision surgery using a glenoid bone graft with a minimum follow-up of 2 years...
April 10, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28406878/bone-loss-in-revision-total-knee-arthroplasty-evaluation-and-management
#8
Neil P Sheth, Marcelo Batista Bonadio, Marco Kawamura Demange
With the increasing number of total knee arthroplasty (TKA) procedures being performed annually, the burden of revision surgery is also expected to increase. Addressing bone loss during revision TKA is a considerable challenge that requires proper preoperative evaluation and surgical planning. In addition to an assessment of femoral and tibial bone loss, a systematic approach to the management of bone loss associated with TKA includes careful implant selection, adherence to the general principles of revision TKA, and an understanding of the available reconstruction options...
May 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28405514/regulatory-b-cells-promote-graft-versus-host-disease-prevention-and-maintain-graft-versus-leukemia-activity-following-allogeneic-bone-marrow-transplantation
#9
Yue Hu, Gan-Lin He, Xiang-Yu Zhao, Xiao-Su Zhao, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xue-Zhong Yu, Kai-Yan Liu, Ying-Jun Chang, Xiao-Jun Huang
Regulatory B cells (Bregs) are involved in the pathogenesis of graft-versus-host disease (GVHD). However, whether Bregs can alleviate acute GVHD without compromising graft-versus-leukemia (GVL) effects remains unclear. Here, we evaluated the role of Bregs in acute GVHD and GVL activity in both a mouse model and a clinical cohort study. In the acute GVHD mouse model, co-transplantation of Bregs prevents onset through inhibiting Th1 and Th17 differentiation and expanding regulatory T cells. In the GVL mouse model, Bregs contributed to the suppression of acute GVHD but had no adverse effect on GVL activity...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28402343/use-of-allograft-with-platelet-concentrate-in-the-treatment-of-multiple-miller-class-iii-gingival-recession-defects-report-of-three-cases
#10
Yumi Ogata, Minh Bui, Terrence J Griffin, Yong Hur
Three patients with multiple Miller Class III recession defects with substantial bone loss were treated with hard tissue augmentation with the goal to prevent future recessions. The surgery involved a full-thickness mucoperiosteal coronally advanced flap, bone grafting, and primary flap closure. Freeze-dried bone allograft (FDBA) in combination with plasma rich in growth factors (PRGF) was grafted during the procedure. After more than 6 months, the treated sites showed soft tissue maturation and esthetic tissue blending...
May 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28393847/knockdown-of-toll-like-receptor-4-signaling-pathways-ameliorate-bone-graft-rejection-in-a-mouse-model-of-allograft-transplantation
#11
Jeng-Long Hsieh, Po-Chuan Shen, Po-Ting Wu, I-Ming Jou, Chao-Liang Wu, Ai-Li Shiau, Chrong-Reen Wang, Hao-Earn Chong, Shu-Han Chuang, Jia-Shiou Peng, Shih-Yao Chen
Non-union occurring in structural bone grafting is a major problem in allograft transplantation because of impaired interaction between the host and graft tissue. Activated toll-like receptor (TLR) induces inflammatory cytokines and chemokines and triggers cell-mediated immune responses. The TLR-mediated signal pathway is important for mediating allograft rejection. We evaluated the effects of local knockdown of the TLR4 signaling pathway in a mouse segmental femoral graft model. Allografts were coated with freeze-dried lentiviral vectors that encoded TLR4 and myeloid differentiation primary response gene 88 (MyD88) short-hairpin RNA (shRNA), which were individually transplanted into the mice...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28392637/long-term-results-of-impaction-bone-grafting-using-a-synthetic-graft-apapore-in-revision-hip-surgery
#12
V Kumar, M Ricks, S Aboul-Enin, D G Dunlop
INTRODUCTION: Impaction Bone grafting (IBG) in Revision THR is challenging and places demands on allograft stores. Identifying a potential synthetic replacement that works in the longer term was the aim of this study. METHODS: We retrospectively reviewed 21 sequential patients who had undergone revision THR using IBG. They were randomised to receive either combined allograft and synthetic graft or Allograft alone. Among the surviving 15 patients, there were total of 25 procedures were carried out...
June 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28391519/cortical-onlay-strut-allograft-with-cerclage-wiring-of-periprosthetic-fractures-of-the-humerus-without-stem-loosening-technique-and-preliminary-results
#13
André Thés, Shahnaz Klouche, Marine de Tienda, Thomas Bauer, Philippe Hardy
The goal of this study was to describe an internal fixation technique for periprosthetic humeral fractures using a cortical onlay strut allograft stabilized with cerclage wires and to evaluate the preliminary results of this approach. An anterolateral approach was used to direct access the fracture and to protect the radial nerve. The fracture was reduced with two forceps, under visual control. The fracture was surrounded by two hemicylinder tibial allografts, placed around the humerus with no prior reaming to create a "sarcophagus" system...
April 8, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28385943/is-there-still-a-role-for-osteoarticular-allograft-reconstruction-in-musculoskeletal-tumour-surgery-a-long-term-follow-up-study-of-38-patients-and-systematic-review-of-the-literature
#14
M P A Bus, M A J van de Sande, A H M Taminiau, P D S Dijkstra
AIMS: To assess complications and failure mechanisms of osteoarticular allograft reconstructions for primary bone tumours. PATIENTS AND METHODS: We retrospectively evaluated 38 patients (28 men, 74%) who were treated at our institution with osteoarticular allograft reconstruction between 1989 and 2010. Median age was 19 years (interquartile range 14 to 32). Median follow-up was 19.5 years (95% confidence interval (CI) 13.0 to 26.1) when 26 patients (68%) were alive...
April 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28385038/review-of-mechanical-processing-and-immunologic-factors-associated-with-outcomes-of-fresh-osteochondral-allograft-transplantation-of-the-talus
#15
Chikezie N Okeagu, Erin A Baker, Nicholas A Barreras, Zachary M Vaupel, Paul T Fortin, Kevin C Baker
Osteochondral lesions of the talus (OLTs) are an increasingly implicated cause of ankle pain and instability. Several treatment methods exist with varying clinical outcomes. Due in part to successful osteochondral allografting (OCA) in other joints, such as the knee and shoulder, OCA has gained popularity as a treatment option, especially in the setting of large lesions. The clinical outcomes of talar OCA have been inconsistent relative to the positive results observed in other joints. Current literature regarding OCA failure focuses mainly on 3 factors: the effect of graft storage conditions on chondrocyte viability, graft/lesion size, and operative technique...
April 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28378568/rapid-prototyping-technology-and-its-application-in-bone-tissue-engineering
#16
Bo Yuan, Sheng-Yuan Zhou, Xiong-Sheng Chen
Bone defects arising from a variety of reasons cannot be treated effectively without bone tissue reconstruction. Autografts and allografts have been used in clinical application for some time, but they have disadvantages. With the inherent drawback in the precision and reproducibility of conventional scaffold fabrication techniques, the results of bone surgery may not be ideal. This is despite the introduction of bone tissue engineering which provides a powerful approach for bone repair. Rapid prototyping technologies have emerged as an alternative and have been widely used in bone tissue engineering, enhancing bone tissue regeneration in terms of mechanical strength, pore geometry, and bioactive factors, and overcoming some of the disadvantages of conventional technologies...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28373938/arthroscopic-acromioclavicular-joint-reconstruction-using-knotless-coracoclavicular-fixation-and-soft-tissue-anatomic-coracoclavicular-ligament-reconstruction
#17
Travis J Menge, Dimitri S Tahal, J Christoph Katthagen, Peter J Millett
Acromioclavicular joint injuries are one of the most common shoulder injuries, and there are a variety of treatment options. Recently, there have been newer arthroscopic techniques that have addressed coracoid and clavicle fracture risk by using a knotted suture-button fixation through a single, small bone tunnel with additional looped soft-tissue graft stabilization. Although clinical outcomes have been good to excellent, there have still been instances of knot and hardware irritation. The described technique builds on the latest advances and achieves an anatomic coracoclavicular (CC) reconstruction through a single knotless CC fixation device with additional soft-tissue allograft reconstruction of the CC ligaments...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28368373/is-myeloablative-dose-intensity-necessary-in-allogeneic-hematopoietic-cell-transplantation-for-lymphomas
#18
REVIEW
M A Kharfan-Dabaja, N El-Jurdi, E Ayala, A S Kanate, B N Savani, M Hamadani
The advent of novel immunotherapy and tyrosine kinase inhibitors has ushered a new era in the treatment of Hodgkin and non-Hodgkin lymphomas. Allogeneic hematopoietic cell transplantation remains, however, a vital component in the management and potential cure of lymphomas, especially in the relapsed setting. Considering the biological and clinical heterogeneity of various subtypes of lymphomas, the optimal intensity of conditioning regimens remains controversial. Reduced intensity conditioning regimens have broadened applicability of the procedure to older and frail patients...
April 3, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/28366746/acetabular-bone-defects-in-tha-revision-reconstruction-using-morsellised-virus-inactivated-bone-allograft-and-reinforcement-ring-seven-year-outcomes-in-95-patients
#19
G Villatte, R Erivan, G Salles, B Pereira, M Galvin, S Descamps, S Boisgard
BACKGROUND: Acetabular cup loosening is among the main reasons for revision total hip arthroplasty (THA). The implantation of a cryopreserved morsellised bone allograft is a reference method for filling bone defects. However, the outcomes of bone grafts treated with viral inactivation and secured into the host bone (notably using a reinforcement device) are unclear. We therefore retrospectively reviewed cases of acetabular revision with morsellised bone allograft implanted into a reinforcement ring for acetabular revision to assess: 1) clinical survival of the acetabular implant (time to new revision with acetabular component removal), 2) radiological implant survival, 3) and bone graft osseointegration evaluated using Oswestry's criteria...
March 30, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28365682/surface-properties-and-mc3t3-e1-cell-response-of-cortical-bone-allografts-modified-with-low-concentration-phosphoric-acid
#20
Zengfa Huang, Cheng Cheng, Jing Wang, Hui Wei, Xianzhe Liu, Xinxin Yan, Yan Zhou, Yunlu Liu, Shuhua Yang
BACKGROUND/AIMS: This experimental study aimed to evaluate the effect of low-concentration phosphoric acid on the surface structure of cortical allografts. METHODS: Allogenic cortical bones were obtained from femurs and tibias of New Zealand white rabbits. The bones were modified by treatment with various concentrations of phosphoric acid (10%, 20% or 30%) for 10, 30 or 60 minutes, then evaluated by the following methods: 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and LIVE/DEAD assay, alkaline phosphatase (ALP) assay, biomechanical properties testing, contact angle detection, quantitative real-time polymerase chain reaction (Q-PCR), western blotting and scanning electron microscopy (SEM)...
March 27, 2017: Cellular Physiology and Biochemistry
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