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Bone allograft

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https://www.readbyqxmd.com/read/28526166/transhumeral-anterior-radial-nerve-transposition-to-simplify-anticipated-future-humeral-reconstruction
#1
REVIEW
David A Muzykewicz, Reid A Abrams
Anterior transhumeral radial nerve transposition has been described in the treatment of humeral shaft fracture to protect the nerve from implant irritation or callus entrapment. Transposing the radial nerve through a facilitating humeral defect also simplifies revision surgery should nonunion result. Here we describe a surgical technique for anterior transhumeral radial nerve transposition for complex humeral reconstruction when subsequent revision surgery is anticipated. Three cases are used for illustration: (1) revision of a total elbow arthroplasty with periprosthetic fracture; (2) revision of a total elbow arthroplasty after aseptic loosening from an allograft/prosthesis composite; and (3) septic humeral nonunion with substantial bone loss...
May 16, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28515335/in-situ-bone-tissue-engineering-via-ultrasound-mediated-gene-delivery-to-endogenous-progenitor-cells-in-mini-pigs
#2
Maxim Bez, Dmitriy Sheyn, Wafa Tawackoli, Pablo Avalos, Galina Shapiro, Joseph C Giaconi, Xiaoyu Da, Shiran Ben David, Jayne Gavrity, Hani A Awad, Hyun W Bae, Eric J Ley, Thomas J Kremen, Zulma Gazit, Katherine W Ferrara, Gadi Pelled, Dan Gazit
More than 2 million bone-grafting procedures are performed each year using autografts or allografts. However, both options carry disadvantages, and there remains a clear medical need for the development of new therapies for massive bone loss and fracture nonunions. We hypothesized that localized ultrasound-mediated, microbubble-enhanced therapeutic gene delivery to endogenous stem cells would induce efficient bone regeneration and fracture repair. To test this hypothesis, we surgically created a critical-sized bone fracture in the tibiae of Yucatán mini-pigs, a clinically relevant large animal model...
May 17, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28507956/an-unusual-case-of-giant-cell-tumor-of-first-metatarsal-a-rare-case-report-and-review-of-literature
#3
Kumar Prashant, Tulsi Das Bhattacharyya, Herman Frank, Prema Ram
INTRODUCTION: Giant cell tumor (GCT) or osteoclastoma is an osteolytic, mostly benign but locally aggressive tumor occurring in young adults at the epiphysis. Area of predilection is mainly long bones (85-90%). 4% of GCT are also found in iliac bone, spine and only 2% in hand (of which GCT phalanges are more common than metacarpal). GCT of metatarsal is a very rare occurrence with very few cases being reported so far. We report a case of GCT 1(st) metatarsal in a 40-year-old male which is a very rare entity...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28507875/digital-joint-reconstruction-with-osteotendinous-joint-allograft-experimental-study-in-rats
#4
Martin Iglesias, Ángel Uriel Cruz-Reyes, Patricia Butrón, Ricardo Hernández-Agallo, Víctor Antonio Torres de la Barrera, Claudio Reyes-Montero, Marta Durand-Carbajal, Gonzalo Torres-Villalobos
BACKGROUND: Fresh or frozen nonvascularized osteotendinous joint allografts (OTJA) have not been used previously, clinically or experimentally, for metacarpophalangeal joint reconstruction. Therefore, we evaluated the viability of OTJA for metatarsophalangeal joint (MTJ) reconstruction in rats. METHODS: In the experimental group of 12 Lewis rats, we reconstructed the MTJ of the third digit of the hindlimb with a fresh, nonvascularized OTJA obtained from the same digit from 12 donor rats...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28505164/human-decellularized-bone-scaffolds-from-aged-donors-show-improved-osteoinductive-capacity-compared-to-young-donor-bone
#5
Christopher A Smith, Tim N Board, Paul Rooney, Mark J Eagle, Stephen M Richardson, Judith A Hoyland
To improve the safe use of allograft bone, decellularization techniques may be utilized to produce acellular scaffolds. Such scaffolds should retain their innate biological and biomechanical capacity and support mesenchymal stem cell (MSC) osteogenic differentiation. However, as allograft bone is derived from a wide age-range, this study aimed to determine whether donor age impacts on the ability an osteoinductive, acellular scaffold produced from human bone to promote the osteogenic differentiation of bone marrow MSCs (BM-MSC)...
2017: PloS One
https://www.readbyqxmd.com/read/28500904/endometrial-adenocarcinoma-recurrence-presenting-with-tibial-metastasis-report-of-a-case
#6
Mehmet Salih Söylemez, Bahattin Kemah, Umut Perçem Orhan Söylemez, Bülent Kılıç, Korhan Ozkan
INTRODUCTION: Metastatic bone disease at extremities is mostly associated with lung, liver, prostat, thyriod or breast malignancies. There for surgeons generally tends to seek for a primary tumor originating from these organs. Herein a case of endometrial adenocarcinoma recurrence that presented with symptoms of tibial pain is described. PRESENTATION OF CASE: 59 year-old woman was admitted to our orthopaedic oncology unit with pain, swelling and tenderness at right cruris for two weeks without any trauma history...
April 18, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28500505/rehydration-improves-the-ductility-of-dry-bone-allografts
#7
Roger Erivan, Guillaume Villatte, Régis Cueff, Stéphane Boisgard, Stéphane Descamps
Processing of bone allografts improves infectious safety and allows storing bone substitutes at room temperature. The aim of this study was to compare mechanical properties of the processed Osteopure™ bone with fresh frozen bone. All the samples were pieces from femoral heads retrieved during hip arthroplasty operations. The processing includes chemical decellularization, drying and irradiation with 25 kGy. Three types of samples were tested: 1. fresh frozen thawed wet, 2. dry non-rehydrated graft 3. dry rehydrated graft...
May 12, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28496119/clinical-experience-with-the-artificial-bone-graft-substitute-calcibon-used-following-curettage-of-benign-and-low-grade-malignant-bone-tumors
#8
Joerg Friesenbichler, Werner Maurer-Ertl, Marko Bergovec, Lukas A Holzer, Kathrin Ogris, Lukas Leitner, Andreas Leithner
Artificial bone graft substitutes, such as Calcibon, are becoming increasingly interesting as they do not cause donor site morbidity which is an advantage compared to autologous bone grafts. The aim of this study was to evaluate the efficacy and potential complications associated with the use of Calcibon. Twenty-seven patients with benign and low-grade malignant bone tumors were treated with curettage and refilling of the bony cavity. Based on the radiological classification system of Neer, these lesions only comprised Grade I lesions, describing cysts that only require curettage and filling, but no additional treatment...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28485126/effects-of-substitute-coated-with-hyaluronic-acid-or-poly-lactic-acid-on-implant-fixation-experimental-study-in-ovariectomized-and-glucocorticoid-treated-sheep
#9
Christina M Andreasen, Ming Ding, Thomas L Andersen, Søren Overgaard
Investigated in healthy animal models, hyaluronic acid (HyA) and poly-D,L -lactic acid (PDLLA) demonstrate osteoconductive properties when coated onto hydroxyapatite (HA) and β-tricalcium phosphate (βTCP) scaffolds. In this study, we examined the efficacy of HA/βTCP granules coated with HyA or PDLLA on implant fixation when applied as graft materials in 2 mm size defects created in the femur condyles of ovariectomized (OVX) glucocorticoid-treated (GC) sheep. Titanium alloys were inserted into the femur condyles of OVX and GC-treated sheep and the concentric gaps were filled with either allograft obtained from a healthy donor sheep (control), pure HA/βTCP, HA/βTCP-HyA or HA/βTCP-PDLLA...
May 8, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28476368/editorial-commentary-distal-tibia-allograft-as-an-option-for-glenoid-reconstruction-in-recurrent-shoulder-instability-it-s-all-about-the-bone
#10
EDITORIAL
Ronak M Patel, Anthony Miniaci
Bony defects in recurrent shoulder instability can lead to the failure of soft tissue reconstruction. Many techniques have been developed to address glenoid defects in an attempt to prevent recurrent instability. However, the high complication rates with the Latarjet procedure have led surgeons to identify other sources of bone graft, including the distal tibia allograft (DTA). The DTA appears to be a suitable option for anterior glenoid reconstruction, highlighting the importance of reconstructing all bony defects and the versatility and efficacy of allograft bone blocks...
May 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28474504/mouse-nidovirus-ldv-infection-alleviates-graft-versus-host-disease-and-induces-type-i-ifn-dependent-inhibition-of-dendritic-cells-and-allo-responsive-t-cells
#11
Mélanie Gaignage, Reece G Marillier, Catherine Uyttenhove, Nicolas Dauguet, Anubha Saxena, Bernard Ryffel, Thomas Michiels, Jean-Paul Coutelier, Jacques Van Snick
INTRODUCTION: Viruses have developed multiple mechanisms to alter immune reactions. In 1969, it was reported that lactate dehydrogenase-elevating virus (LDV), a single stranded positive sense mouse nidovirus, delays skin allograft rejection and inhibits spleen alterations in graft versus host disease (GVHD). As the underlying mechanisms have remained unresolved and given the need for new therapies of this disease, we reassessed the effects of the virus on GVHD and tried to uncover its mode of action...
June 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28467648/building-better-bone-the-weaving-of-biologic-and-engineering-strategies-for-managing-bone-loss
#12
Andrew M Schwartz, Mara L Schenker, Jaimo Ahn, Nick J Willett
Segmental bone loss remains a challenging clinical problem for orthopaedic trauma surgeons. In addition to the missing bone itself, the local tissues (soft tissue, vascular) are often highly traumatized as well, resulting in a less than ideal environment for bone regeneration. As a result, attempts at limb salvage become a highly expensive endeavor, often requiring multiple operations and necessitating the use of every available strategy (autograft, allograft, bone graft substitution, Masquelet, bone transport, etc...
May 3, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28466494/comparison-of-allografts-and-xenografts-used-for-alveolar-ridge-preservation-a-clinical-and-histomorphometric-rct-in-humans
#13
Carlos Alberto Serrano Méndez, Niklaus Peter Lang, Martina Caneva, Gloria Ramírez Lemus, Gerardo Mora Solano, Daniele Botticelli
BACKGROUND: Several types of bone grafts are used in ridge preservation procedures. PURPOSE: To compare the healing of allografts and xenografts applied for alveolar ridge preservation. MATERIALS AND METHODS: Twenty volunteers in need of extraction of a single-rooted tooth prior to implant installation were randomized into two groups. One group received a deproteinized cancellous bovine bone xenograft embedded in a 10% collagen matrix and the other a demineralized freeze-dried cortical bone allograft...
May 2, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28464040/pulsed-lavage-cleansing-of-osteochondral-grafts-depends-on-lavage-duration-flow-intensity-and-graft-storage-condition
#14
Yang Sun, Weibo Jiang, Esther Cory, Jason P Caffrey, Felix H Hsu, Albert C Chen, Jincheng Wang, Robert L Sah, William D Bugbee
INTRODUCTION: Osteochondral allograft (OCA) transplantation is generally effective for treating large cartilage lesions. Cleansing OCA subchondral bone to remove donor marrow elements is typically performed with pulsed lavage. However, the effects of clinical and experimental parameters on OCA marrow removal by pulsed lavage are unknown. The aim of the current study was to determine the effects on marrow cleansing in human osteochondral cores (OCs) of (1) lavage duration, (2) lavage flow intensity, and (3) OC sample type and storage condition...
2017: PloS One
https://www.readbyqxmd.com/read/28463925/construct-rigidity-keystone-for-treating-pelvic-discontinuity
#15
J Ryan Martin, Ian Barrett, Rafael J Sierra, David G Lewallen, Daniel J Berry
BACKGROUND: Pelvic discontinuity is uncommon and presents the surgeon with complex reconstructive challenges. The objective of this study is to report the results of current strategies used in the treatment of pelvic discontinuity. METHODS: We retrospectively analyzed prospectively collected data on 113 consecutive revision total hip arthroplasties performed for the treatment of unilateral pelvic discontinuity at a single institution. The study included 18 male and 95 female patients with a mean age of 63 years at the time of revision surgery...
May 3, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28462604/desmoplastic-fibroma-versus-soft-tissue-desmoid-tumour-of-forearm-a-case-series-of-diagnosis-surgical-approach-and-outcome
#16
K Jamshidi, A Bagherifard, A Mirzaei
We report a case series of aggressive fibromatosis of the forearm and discuss the differentiation criteria of overlapped intra- or extra-osseous origin of aggressive fibromatosis, surgical approach, and outcome. Ten cases of aggressive fibromatosis of the forearm were evaluated. When there was no involvement of vital adjacent structures, such as nerves, vessels, and tendons, en-bloc excision was performed for the removal of the soft-tissue mass. Bone involvement was observed in nine cases. Intercalary allograft was performed whenever one of the forearm bones was involved (six cases), while extensive curettage was used if both forearm bones were affected (three cases)...
April 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28461963/distal-biceps-tendon-injuries-a-clinically-relevant-current-concepts-review
#17
Eduard Alentorn-Geli, Andrew T Assenmacher, Joaquín Sánchez-Sotelo
Distal biceps tendon (DBT) conditions comprise a spectrum of disorders including bicipitoradial bursitis, partial tears, acute and chronic complete tears.In low-demand patients with complete DBT tears, non-operative treatment may be entertained provided the patient understands the potential for residual weakness, particularly in forearm supination.Most acute tears are best treated by primary repair using either single-incision or double-incision techniques with good clinical outcomes.Single-incision techniques may carry a higher risk of nerve-related complications, whereas double-incision techniques have historically been considered to carry a higher risk of heterotopic ossification, particularly if the ulna is exposed...
September 2016: EFORT Open Rev
https://www.readbyqxmd.com/read/28461922/bone-grafts-bone-graft-extenders-substitutes-and-enhancers-for-acetabular-reconstruction-in-revision-total-hip-arthroplasty
#18
REVIEW
Luca Pierannunzii, Luigi Zagra
Acetabular bone loss is a relevant concern for surgeons dealing with a failed total hip arthroplasty.Since the femoral head is no longer available, allografts represent the first choice for most reconstructive solutions, either as a structural buttress or impacted bone chips.Even though fresh-frozen bone is firmly recommended for structural grafts, freeze-dried and/or irradiated bone may be used alternatively for impaction grafting. Indeed, there are some papers on freeze-dried or irradiated bone impaction grafting, but their number is limited, as is the number of cases...
December 2016: EFORT Open Rev
https://www.readbyqxmd.com/read/28459780/preoperative-radiographic-parameters-to-predict-a-higher-pseudarthrosis-rate-following-anterior-cervical-discectomy-and-fusion
#19
Sung Hoon Choi, Jae Hwan Cho, Chang Ju Hwang, Choon Sung Lee, Hyun Wook Gwak, Dong-Ho Lee
STUDY DESIGN: Retrospective study. OBJECTIVE: To determine whether postoperative pseudarthrosis can be predicted from specific preoperative radiograph measurements. SUMMARY OF BACKGROUND DATA: Various factors reportedly influence the occurrence of pseudarthrosis after anterior cervical discectomy and fusion (ACDF). However, to our knowledge, there are no reports on the relationships between preoperative radiographic parameters and pseudarthrosis...
April 28, 2017: Spine
https://www.readbyqxmd.com/read/28458784/evaluating-the-functional-results-and-complications-of-autograft-vs-allograft-use-for-reconstruction-of-the-anterior-cruciate-ligament-a-systematic-review
#20
REVIEW
Ojas Pujji, Nikita Keswani, Naomi Collier, Marion Black, Lucy Doos
The aim of our review is to identify the reconstruction technique that has a superior functional outcome and decreased number of complications for the anterior cruciate ligament (ACL). We have divided our review into 2 sections. Our primary question evaluates the functional results and complications of autografts compared to allografts for ACL reconstruction. Our subsidiary question evaluates the functional results and complications of bone-patellar tendon-bone (BPTB) autografts compared to hamstring tendon autografts...
February 20, 2017: Orthopedic Reviews
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