keyword
MENU ▼
Read by QxMD icon Read
search

Lipids and dyslipidemia

keyword
https://www.readbyqxmd.com/read/29773001/combined-administration-of-monosodium-glutamate-and-high-sucrose-diet-accelerates-the-induction-of-type-2-diabetes-vascular-dysfunction-and-memory-impairment-in-rats
#1
Kaja Saikrishna, Ringu Kumari, Kantamaneni Chaitanya, Subhankar Biswas, Pawan G Nayak, Jayesh Mudgal, Anoop Kishore, Krishnadas Nandakumar
In this study, we aimed to develop an experimental animal model for type 2 diabetes mellitus (T2DM) using a combination of monosodium glutamate (MSG) and high sucrose diet (HSD). Young male Wistar rats (20-30 g) were injected with MSG (2 or 4 mg/g, i.p. for 4 days). These rats were also fed an HSD, while the control group was fed a starch diet (SFD) for 150 days. Parameters assessed periodically were body weight, feed intake, blood glucose level, and oral glucose tolerance test (OGTT), lipid profile, liver and kidney function tests, skeletal muscle glucose uptake, cognitive function tests, and microvascular changes using isolated rat aorta...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29771737/ethnic-disparities-in-treatment-rates-for-hypertension-and-dyslipidemia-an-analysis-by-different-treatment-indications-the-healthy-life-in-an-urban-setting-study
#2
Wilco Perini, Charles Agyemang, Marieke B Snijder, Ron J G Peters, Anton E Kunst
BACKGROUND: Studies have reported ethnic disparities in treatment rates for cardiovascular risk factors. These studies are generally based on treatment indications defined by individual cardiovascular risk factors (ICRF). However, according to most European guidelines, preventive treatment for these risk factors is recommended only among those with sufficient overall cardiovascular risk (OCR). OBJECTIVE: To determine ethnic disparities in treatment rates for hypertension and dyslipidemia among those with an indication for treatment based on ICRF and OCR...
May 15, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29768640/lipoprotein-profile-modifications-during-gestation-a-current-approach-to-cardiovascular-risk-surrogate-markers-and-maternal-fetal-unit-complications
#3
Ana Paula Caires Dos Santos, Ricardo David Couto
Several changes occur in lipid metabolism during gestation due to hormonal and metabolic changes, which are essential to satisfy the nutritional demands of the maternal-fetal unit development. The gestation shows two distinct periods that begin with fat accumulation, mainly in maternal adipose tissue, and the late phase, characterized by accelerated catabolism, with the increase of fatty acids in the circulation that causes hyperlipidemia, especially the one characterized as hypertriglyceridemia. Maternal hyperlipidemia may be associated with the development of maternal-fetal complications (preterm birth, preeclampsia, vascular complications) and the development of long-term cardiovascular disease...
May 16, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29764933/discovery-of-peroxisome-proliferator-activated-receptor-%C3%AE-ppar%C3%AE-activators-with-a-ligand-screening-system-using-a-human-ppar%C3%AE-expressing-cell-line
#4
Keisuke Tachibana, Tomohiro Yuzuriha, Ryotaro Tabata, Syohei Fukuda, Takashi Maegawa, Rika Takahashi, Keiichi Tanimoto, Hirofumi Tsujino, Kazuto Nunomura, Bangzhong Lin, Yoshiharu Matsuura, Toshiya Tanaka, Takao Hamakubo, Juro Js Sakai, Tatsuhiko Kodama, Tadayuki Kobayashi, Kenji Ishimoto, Hiroyuki Miyachi, Takefumi Doi
Peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcription factor that belongs to the superfamily of nuclear hormone receptors. PPARα is mainly expressed in the liver, where it activates fatty acid oxidation and lipoprotein metabolism and improves plasma lipid profiles. Therefore, PPARα activators are often used to treat patients with dyslipidemia. To discover additional PPARα activators as potential compounds for use in hypolipidemic drugs, here we established human hepatoblastoma cell lines with luciferase reporter expression from the promoters containing peroxisome proliferator responsive elements (PPRE) and tetracycline-regulated expression of full-length human PPARα to quantify the effects of chemical ligands on PPARα activity...
May 15, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29763709/fenofibrate-effects-on-carotid-artery-intima-media-thickness-in-adults-with-type-2-diabetes-mellitus-a-field-substudy
#5
Jason A Harmer, Anthony C Keech, Anne-Sophie Veillard, Michael R Skilton, Gerald F Watts, David S Celermajer
AIM: Dyslipidemia in type 2 diabetes contributes to an increased risk of cardiovascular disease. Fenofibrate, a lipid-regulating peroxisome proliferator-activated receptor-α (PPARα) agonist, has been shown to reduce vascular complications in adults with type 2 diabetes. The mechanisms for such benefit, however, are not yet well understood. We examined the effects of fenofibrate on carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis, in adults with type 2 diabetes...
May 12, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29761548/variation-of-carotid-intima-media-thickness-with-body-mass-index-in-healthy-adults-of-black-african-descent
#6
Adesola Abiodun Asaleye, Kolawole Thomas Braimoh, Olalekan Ibukun Oyinloye, Christianah Mopelola Asaleye, Adeleye Dorcas Omisore
OBJECTIVES: Studies have shown that common carotid intima media thickness (CIMT) measured by B-mode sonography increases with body mass index (BMI) among subjects with cardiovascular diseases in different populations. However, association of body fat and subclinical atherosclerosis in the absence of these cardiovascular diseases is understudied. We aimed to evaluate the correlation between BMI and CIMT in a healthy adult population of black African ancestry. METHODS: This is a cross-sectional prospective study in 300 consecutive apparently healthy subjects aged 18 to 70 years without history of hypertension, dyslipidemia, diabetes mellitus, and renal disease...
May 15, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29758349/habitual-aerobic-exercise-gene-apoa5-named-rs662799-snp-and-response-of-blood-lipid-and-lipoprotein-phenotypes-among-older-chinese-adult
#7
Xiangyun Liu, Guoyuan Huang, Zhanbin Niu, Yuqin Wei, Ru Wang
BACKGROUND: The genetic component of dyslipidemia has been studied in adults but little in older population. It is remains unknown regarding influence and interaction of APOA5 gene single nucleotide polymorphism (SNP) and habitual aerobic exercise (HAE) on changes of blood lipids and lipoprotein phenotypes in older Chinese adults. METHODS: Four-hundred-twenty-three old Chinese individuals with HAE were divided into hyperlipidemia and normal groups. We genotyped polymorphic loci using matrix assisted laser desorption ionization time of flight mass spectrometry detection technology (MALDI-TOF)...
May 11, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29758034/interactions-among-genes-involved-in-reverse-cholesterol-transport-and-in-the-response-to-environmental-factors-in-dyslipidemia-in-subjects-from-the-xinjiang-rural-area
#8
Xinping Wang, Heng Guo, Yu Li, Haixia Wang, Jia He, Lati Mu, Yunhua Hu, Jiaolong Ma, Yizhong Yan, Shugang Li, Yusong Ding, Mei Zhang, Qiang Niu, Jiaming Liu, Jingyu Zhang, Rulin Ma, Shuxia Guo
Gene-gene and gene-environment interactions may be partially responsible for dyslipidemia, but studies investigating interactions in the reverse cholesterol transport system (RCT) are limited. We explored these interactions in a Xinjiang rural population by genotyping five SNPs using SNPShot technique in APOA1, ABCA1, and LCAT, which are involved in the RCT (690 patients, 743 controls). We conducted unconditional logistical regression analysis to evaluate associations and generalized multifactor dimensionality reduction to evaluate interactions...
2018: PloS One
https://www.readbyqxmd.com/read/29755645/hepatic-steatosis-in-chronic-hepatitis-b-a-study-of-metabolic-and-genetic-factors
#9
Michael O Baclig, Karen G Reyes, Veni R Liles, Cynthia A Mapua, Mark Pierre S Dimamay, Juliet Gopez-Cervantes
Hepatic steatosis is a common finding in liver biopsy and may co-exist with chronic hepatitis B (CHB) infection. The aims of this study were to determine the prevalence of steatosis in CHB patients among Filipinos; determine the factors related to the presence of steatosis among individuals with and without CHB infection; and to investigate the possible association between steatosis and polymorphism in interleukin 28B (IL28B) gene. The presence of steatosis was correlated with clinical, biochemical and histological parameters...
2018: International Journal of Molecular Epidemiology and Genetics
https://www.readbyqxmd.com/read/29754716/sex-disparity-persists-in-the-prevention-of-cardiovascular-disease-in-women-on-statin-therapy-compared-to-that-in-men
#10
S Moreno-Arellano, J Delgado-de-Mendoza, M J Santi-Cano
BACKGROUND AND AIMS: The aim of this study was to assess whether women differ from men with regard to lowering lipid levels, achieving target of optimal lipid levels, and analyzing evidence-based dose and intensity of statin prescription in primary care patients. METHODS AND RESULTS: A multicenter cross-sectional survey was conducted among 1046 patients with dyslipidemia (554 women) who were receiving statin therapy from the Primary Health Care of Andalucía (Spain)...
April 7, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29754388/consumption-of-probiotic-lactobacillus-fermentum-mtcc-5898-fermented-milk-attenuates-dyslipidemia-oxidative-stress-and-inflammation-in-male-rats-fed-on-cholesterol-enriched-diet
#11
Radha Yadav, Suhail Hakeem Khan, Sanusi Bello Mada, Sunita Meena, Rajeev Kapila, Suman Kapila
There is a growing and alarming prevalence that increased serum cholesterol is closely related to increased cardiovascular disease risk. Probiotic consumption could be a safe and natural strategy to combat. Therefore, we sought to examine the cholesterol-lowering potential of co-supplementation of probiotic bacteria Lactobacillus fermentum MTCC: 5898-fermented buffalo milk (2.5% fat) in rats fed cholesterol-enriched diet. Male Wistar rats were divided into three groups on the basis of feed, viz. group 1, fed standard diet (SD); group 2, fed cholesterol-enriched diet (CED); and group 3, fed cholesterol-enriched diet along with L...
May 13, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29754168/acromegaly-is-associated-with-high-fibroblast-growth-factor-21-levels
#12
B S Yurekli, N O Kutbay, M Aksit, A Suner, I Y Simsir, S Seckiner, G U Kocabas, G Bozkaya, F Saygili
PURPOSE: Fibroblast growth factor-21 (FGF-21) is a member of fibroblast growth factor family. Both growth hormone (GH) and FGF-21 take place in the regulation of glucose and lipid metabolism. We aimed to investigate FGF-21 levels in acromegaly which is characterized by excess GH levels and is associated with comorbidities and altered body composition. METHODS: We studied 43 subjects (21 females and 22 males, mean age of 50.0 ± 12.8) with acromegaly. The control group consisted of 40 gender- and age-matched subjects (25 females and 15 males, mean age of 48...
May 12, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29753732/niacin-action-in-the-atherogenic-mixed-dyslipidemia-of-metabolic-syndrome-insights-from-metabolic-biomarker-profiling-and-network-analysis
#13
Martin Adiels, M John Chapman, Paul Robillard, Michel Krempf, Martine Laville, Jan Borén
BACKGROUND: Niacin as an adjunct to statin treatment to reduce cardiovascular risk is questioned. OBJECTIVE: To evaluate interrelationships between the effects of niacin on mixed dyslipidemia and a spectrum of metabolic and inflammatory biomarkers. METHODS: Obese, nondiabetic, hypertriglyceridemic males (n = 19) with low high-density lipoprotein-cholesterol levels received extended-release nicotinic acid for 8 weeks. Multiple biomarkers were measured using enzyme-linked immunosorbent assay, enzymatic/absorptiometric, or multiplex biochip assays...
March 29, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29753422/prevalence-of-diabetes-and-dyslipidemia-in-hypertensive-patients-in-the-area-of-blida-algeria
#14
A Bachir Cherif, S Bennouar, A Bouamra, A Taleb, F Hamida, M Temmar, M T Bouafia
PURPOSE: Diabetes mellitus (DM) and lipid disorders (LD) in hypertensive patients are associated with an increased risk of cardiovascular complications requiring follow-up and more aggressive therapeutic strategies. The main objective of this study was to describe the prevalence of DM and LD in adult hypertensive patients followed in specialized consultation of hypertension in the region of Blida (North Algeria) during the period from January 2013 to June 2017. MATERIALS AND METHODS: We included 3268 hypertensive patients (1453 men and 1815 women), mean age of 58...
May 9, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29751292/dietary-protein-dilution-limits-dyslipidemia-in-obesity-through-fgf21-driven-fatty-acid-clearance
#15
Adriano Maida, Annika Zota, Alexandros Vegiopoulos, Sila Appak-Baskoy, Hellmut G Augustin, Mathias Heikenwalder, Stephan Herzig, Adam J Rose
Recent studies have demonstrated that dietary protein dilution (PD) can promote metabolic inefficiency and improve glucose metabolism. However, whether PD can promote other aspects of metabolic health, such as improve systemic lipid metabolism, and mechanisms therein remains unknown. Mouse models of obesity, such as high-fat-diet-fed C57Bl/6 N mice, and New Zealand Obese mice were fed normal (i.e., 20%P) and protein-dilute (i.e., 5%EP) diets. FGF21-/- and Cd36-/- and corresponding littermate +/+ controls were also studied to examine gene-diet interactions...
April 7, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29750655/metabolic-risk-factors-in-adolescent-girls-with-type-1-diabetes
#16
Cíntia Castro-Correia, Rita Santos-Silva, Marta Pinheiro, Carla Costa, Manuel Fontoura
BACKGROUND: The incidence of pediatric metabolic syndrome (MS) has progressively increased. The incidence of type 1 diabetes mellitus (T1DM) has also increased. Thus, some children and adolescents with T1DM exhibit MS parameters. The aim of the study was to evaluate the presence of MS parameters in female adolescents with T1DM based on their nutritional status. METHODS: We evaluated 44 adolescents with T1DM (consecutive non-randomized sample) aged between 14 and 18 years, who were on intensive therapy with insulin...
May 11, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29749982/prevalence-of-multiple-coronary-artery-disease-risk-factors-in-kerman-a-population-based-study-in-southeast-iran
#17
Hamid Najafipour, Mahdi Afshari, Farzaneh Rostamzadeh
Background: The risk of disease with 1 risk factor is increased by the presence of additional risk factors. The goal of this study was to assess the prevalence of multiple coronary artery disease (CAD) risk factors among adults in Kerman, Iran, to identify the population groups most at risk. Methods: The present study included 5900 adults aged between 15 and 75 years in 2011 in Kerman, Iran. They were selected by 1-stage cluster sampling. Blood pressure, fasting blood glucose, lipids, and 6 CAD risk factors were assessed in the study population...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29747212/association-between-insulin-resistance-and-cardiovascular-risk-factors-in-polycystic-ovary-syndrome-patients
#18
Miriam da Silva Wanderley, Lara Cristina Ribeiro Pereira, Carla Borges Santos, Vinícius Santos da Cunha, Mariam Viviane Jovino Neves
OBJECTIVE:  To analyze the association between the indirect methods of evaluating insulin resistance (IR) and blood pressure, anthropometric and biochemical parameters in a population of polycystic ovary syndrome (PCOS) patients. METHODS:  Cross-sectional study performed at the Hospital Universitário de Brasília (HUB, in the Portuguese acronym) involving PCOS patients diagnosed from January 2011 to January 2013. Four indirect methods, namely, fasting blood insulin level, fasting glucose/insulin ratio (G/I), homeostatic model-assessment-insulin resistance (HOMA-IR), and the quantitative insulin sensitivity check index (QUICKI), were used to obtain the IR diagnosis...
April 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29746866/cav-1-promotes-atherosclerosis-by-activating-jnk-associated-signaling
#19
Dong-Xia Wang, Yong-Quan Pan, Bing Liu, Li Dai
The objective of the study is to calculate the role and underlying the molecular mechanisms of caveolin-1 (Cav-1) in atherosclerosis (AS). Cav-1 was mainly expressed in the endothelial cells of atherosclerotic lesions in both human patients and apolipoprotein E deficient (ApoE-/- ) mice. Cav-1 deficiency (Cav-1-/- ) attenuated high-fat diet (HFD)-induced atherosclerotic lesions in ApoE-/- mice, supported by the reduced aortic plaques. Cav-1-/- reduced the macrophage content and decreased the release of inflammation-related cytokines or chemokine in serum or abdominal aortas, accompanied with the inactivation of inhibitor κB kinase κ (IKKβ)/p65/IκBα signaling pathway...
May 7, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29746616/a-regulatory-insertion-deletion-polymorphism-in-the-fads-gene-cluster-influences-pufa-and-lipid-profiles-among-chinese-adults-a-population-based-study
#20
Peiqin Li, Jing Zhao, Kumar S D Kothapalli, Xiang Li, Hui Li, Yuxuan Han, Shengquan Mi, Wenhua Zhao, Qizhai Li, Hong Zhang, Yiqing Song, J Thomas Brenna, Ying Gao
Background: Arachidonic acid (AA) is the major polyunsaturated fatty acid (PUFA) substrate for potent eicosanoid signaling to modulate inflammation and thrombosis and is controlled in part by tissue abundance. Fatty acid desaturase 1 (FADS1) catalyzes synthesis of omega-6 (n-3) AA and n-3 eicosapentaenoic acid (EPA). The rs66698963 polymorphism, a 22-base pair (bp) insertion-deletion 137 bp downstream of a sterol regulatory element in FADS2 intron 1, mediates expression of FADS1 in vitro, as well as exerting positive selection in several human populations...
May 9, 2018: American Journal of Clinical Nutrition
keyword
keyword
120055
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"