Vivian K Lee, Taewoo Lee, Amrit Ghosh, Tanmoy Saha, Manish V Bais, Kala Kumar Bharani, Milan Chag, Keyur Parikh, Parloop Bhatt, Bumseok Namgung, Geethapriya Venkataramanan, Animesh Agrawal, Kiran Sonaje, Leo Mavely, Shiladitya Sengupta, Raghunath Anant Mashelkar, Hae Lin Jang
Hemostatic devices are critical for managing emergent severe bleeding. With the increased use of anticoagulant therapy, there is a need for next-generation hemostats. We rationalized that a hemostat with an architecture designed to increase contact with blood, and engineered from a material that activates a distinct and undrugged coagulation pathway can address the emerging need. Inspired by lung alveolar architecture, here, we describe the engineering of a next-generation single-phase chitosan hemostat with a tortuous spherical microporous design that enables rapid blood absorption and concentrated platelets and fibrin microthrombi in localized regions, a phenomenon less observed with other classical hemostats without structural optimization...
January 30, 2024: Proceedings of the National Academy of Sciences of the United States of America