Danelia Mendieta, Dora Luz De la Cruz-Aguilera, Maria Isabel Barrera-Villalpando, Enrique Becerril-Villanueva, Rodrigo Arreola, Erick Hernández-Ferreira, Sonia Mayra Pérez-Tapia, Gilberto Pérez-Sánchez, María Eugenia Garcés-Alvarez, Lucinda Aguirre-Cruz, Marco Antonio Velasco-Velázquez, Lenin Pavón
Fibromyalgia (FM) is a chronic disease that has been linked to inflammatory reactions and changes in the systemic levels of proinflammatory cytokines that modulate responses in the sympathetic nervous system and hypothalamic-pituitary-adrenal axis. We found that concentrations of IL-6 and IL-8 were elevated in FM patients. Both cytokines correlated with clinical scores, suggesting that IL-6 and IL-8 have additive or synergistic effects in perpetuating the chronic pain in FM patients. These findings indicate that IL-6 and IL-8 are two of the most constant inflammatory mediators in FM and that their levels correlate significantly with the severity of symptoms...
January 15, 2016: Journal of Neuroimmunology