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https://www.readbyqxmd.com/read/29672972/metabolomic-profiling-and-biological-investigation-of-the-marine-sponge-derived-bacterium-rhodococcus-sp-ua13
#1
Yasmin Elsayed, John Refaat, Usama Ramadan Abdelmohsen, Eman Maher Othman, Helga Stopper, Mostafa Ahmed Fouad
INTRODUCTION: Marine sponge-associated actinomycetes are potent sources of bioactive natural products of pharmaceutical significance. They also contributed to the discovery of several clinically relevant antimicrobials. OBJECTIVE: To apply the non-targeted metabolomics approach in chemical profiling of the sponge-derived bacterium Rhodococcus sp. UA13, formerly recovered from the Red Sea sponge Callyspongia aff. Implexa, along with testing for the anti-infective potential of its different fractions...
April 19, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29662480/comparative-analysis-of-the-microbiota-between-sheep-rumen-and-rabbit-cecum-provides-new-insight-into-their-differential-methane-production
#2
Lan Mi, Bin Yang, Xialu Hu, Yang Luo, Jianxin Liu, Zhongtang Yu, Jiakun Wang
The rumen and the hindgut represent two different fermentation organs in herbivorous mammals, with the former producing much more methane than the latter. The objective of this study was to elucidate the microbial underpinning of such differential methane outputs between these two digestive organs. Methane production was measured from 5 adult sheep and 15 adult rabbits, both of which were placed in open-circuit respiratory chambers and fed the same diet (alfalfa hay). The sheep produced more methane than the rabbits per unit of metabolic body weight, digestible neutral detergent fiber, and acid detergent fiber...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29655730/nmr-and-gc-ms-based-metabolomic-characterization-of-sunki-an-unsalted-fermented-pickle-of-turnip-leaves
#3
Satoru Tomita, Toshihide Nakamura, Sanae Okada
This study revealed the compositional characteristics of sunki, a traditional, unsalted, lactic acid-fermented pickle produced using turnip leaf in Kiso district, Japan. Comprehensive compositional analysis by two metabolomic approaches based on NMR and solid-phase microextraction-GC/MS methods was used to determine its chemical composition by annotating 54 water-soluble and 62 volatile compounds. Principal component analysis showed that samples had different compositions, depending on the agricultural processing factory and production year...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29642378/pasture-feeding-changes-the-bovine-rumen-and-milk-metabolome
#4
Tom F O'Callaghan, Rosa Vázquez-Fresno, Arnau Serra-Cayuela, Edison Dong, Rupasri Mandal, Deirdre Hennessy, Stephen McAuliffe, Pat Dillon, David S Wishart, Catherine Stanton, R Paul Ross
The purpose of this study was to examine the effects of two pasture feeding systems-perennial ryegrass (GRS) and perennial ryegrass and white clover (CLV)-and an indoor total mixed ration (TMR) system on the (a) rumen microbiome; (b) rumen fluid and milk metabolome; and (c) to assess the potential to distinguish milk from different feeding systems by their respective metabolomes. Rumen fluid was collected from nine rumen cannulated cows under the different feeding systems in early, mid and late lactation, and raw milk samples were collected from ten non-cannulated cows in mid-lactation from each of the feeding systems...
April 6, 2018: Metabolites
https://www.readbyqxmd.com/read/29601848/food-safety-using-nmr-based-metabolomics-assessment-of-the-atlantic-bluefin-tuna-thunnus-thynnus-from-the-mediterranean-sea
#5
Tiziana Cappello, Alessia Giannetto, Vincenzo Parrino, Giuseppe De Marco, Angela Mauceri, Maria Maisano
Seafood is a valuable component of human diet because of its nutritional properties. The Atlantic bluefin tuna Thunnus thynnus is a scombroid fish highly appreciated as seafood worldwide. Being a top pelagic predator, concerns have been raised over human health risks due to its consumption. Therefore, herein it was comprehensively evaluated the health status and potential metabolite shifts between sexes of bluefin tuna from the Mediterranean Sea, proved to bioaccumulate environmental obesogens, namely polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) at hepatic level...
March 27, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29596720/differential-mobility-spectrometry-dms-reveals-the-elevation-of-urinary-acetylcarnitine-in-non-human-primates-nhps-exposed-to-radiation
#6
Nicholas B Vera, Zhidan Chen, Evan Pannkuk, Evagelia C Laiakis, Albert J Fornace, Derek M Erion, Stephen L Coy, Jeffrey A Pfefferkorn, Paul Vouros
Acetylcarnitine has been identified as one of several urinary biomarkers indicative of radiation exposure in adult rhesus macaque monkeys (non-human primates, NHPs). Previous work has demonstrated an up-regulated dose-response profile in a balanced male/female NHP cohort1 . As a contribution toward the development of metabolomics-based radiation biodosimetry in human populations and other applications of acetylcarnitine screening, we have developed a quantitative, high-throughput method for the analysis of acetylcarnitine...
March 29, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29596368/uhplc-ms-metabolome-fingerprinting-the-isolation-of-main-compounds-and-antioxidant-activity-of-the-andean-species-tetraglochin-ameghinoi-speg-speg
#7
Lorena Luna, Mario J Simirgiotis, Beatriz Lima, Jorge Bórquez, Gabriela E Feresin, Alejandro Tapia
The seriated extracts of petroleum ether (PE-E), dichloromethane (DCM-E) and methanol extracts (MeOH-E) from the aerial parts of the native South American plant Tetraglochin ameghinoi (Rosaceae), were evaluated regarding their antioxidant and antibacterial activities. The antioxidant properties were evaluated by free radical scavenging methods (DPPH and TEAC), ferric-reducing antioxidant power (FRAP) and lipoperoxidation in erythrocytes (LP), while the antibacterial activity was performed against Gram-positive and Gram-negative bacteria according to the Clinical and Laboratory Standards Institute (CLSI) guidelines...
March 29, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29560630/-effect-of-electroacupuncture-at-neiguan-pc-6-on-serum-and-myocardial-metabolites-in-rats-with-myocardial-ischemia-reperfusion-injury-based-on-nuclear-magnetic-resonance-spectroscopy
#8
Ya-Ni Tang, Cheng-Fu Tan, Wei-Wei Liu, Jie Yan, Chao Wang, Mi Liu, Dong-Hai Lin, Cai-Hua Huang, Lin Du, Mei-Lin Chen, Jiao-Lan Li, Ding-Ming Zhu
OBJECTIVE: We have repeatedly demonstrated that electroacupuncture (EA) of "Neiguan"(PC 6) can improve myocardial ischemia in rats. The present study was designed to investigate the metabolomic profile of peripheral blood se-rum and myocardium involving EA-induced improvement of myocardial ischemia-reperfusion injury (MIRI) in rats by using nuclear magnetic resonance spectroscopy. METHODS: Thirty male SD rats were equally randomized into blank control, model and EA groups...
March 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29535763/genetic-markers-are-associated-with-the-ruminal-microbiome-and-metabolome-in-grain-and-sugar-challenged-dairy-heifers
#9
Helen M Golder, Jennifer M Thomson, Stuart E Denman, Chris S McSweeney, Ian J Lean
Dairy heifers were subjected to a non-life-threatening challenge designed to induce ruminal acidosis by feeding grain and sugar. Large among animal variation in clinical signs of acidosis, rumen metabolite concentrations, and the rumen microbiome occurred. This exploratory study investigates sources of the variation by examining associations between the genome, metabolome, and microbiome, albeit with a limited population. The broader objective is to provide a rationale for a larger field study to identify markers for susceptibility to ruminal acidosis...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29527304/metabolomics-characterization-of-colostrum-in-three-sow-breeds-and-its-influences-on-piglets-survival-and-litter-growth-rates
#10
Gianfranco Picone, Martina Zappaterra, Diana Luise, Alessia Trimigno, Francesco Capozzi, Vincenzo Motta, Roberta Davoli, Leonardo Nanni Costa, Paolo Bosi, Paolo Trevisi
Background: Colostrum is the first secretion produced by mammary glands during the hours immediately preceding and succeeding parturition. This secretion differs from milk and represents an essential vehicle of passive immunity, prebiotic compounds and growth factors involved in intestinal development. Most of the literature concerning colostrum composition refers mainly to human and cow; and little is known about pig colostrum metabolome and how it varies between pig breeds and different farrowing parity...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29507607/h-2-drives-metabolic-rearrangements-in-gas-fermenting-clostridium-autoethanogenum
#11
Kaspar Valgepea, Renato de Souza Pinto Lemgruber, Tanus Abdalla, Steve Binos, Nobuaki Takemori, Ayako Takemori, Yuki Tanaka, Ryan Tappel, Michael Köpke, Séan Dennis Simpson, Lars Keld Nielsen, Esteban Marcellin
Background: The global demand for affordable carbon has never been stronger, and there is an imperative in many industrial processes to use waste streams to make products. Gas-fermenting acetogens offer a potential solution and several commercial gas fermentation plants are currently under construction. As energy limits acetogen metabolism, supply of H2 should diminish substrate loss to CO2 and facilitate production of reduced and energy-intensive products. However, the effects of H2 supply on CO-grown acetogens have yet to be experimentally quantified under controlled growth conditions...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29505241/expanding-the-coverage-of-the-metabolome-with-nitrogen-based-nmr
#12
Fatema Bhinderwala, Samantha Lonergan, Jade Woods, Chunyi Zhou, Paul D Fey, Robert Powers
Isotopically labeling a metabolite and tracing its metabolic fate has provided invaluable insights about the role of metabolism in human diseases in addition to a variety of other issues.13 C-labeled metabolite tracers or unlabeled1 H-based NMR experiments are currently the most common application of NMR to metabolomics studies. Unfortunately, the coverage of the metabolome has been consequently limited to the most abundant carbon-containing metabolites. To expand the coverage of the metabolome and enhance the impact of metabolomics studies, we present a protocol for15 N-labeled metabolite tracer experiments that may also be combined with routine13 C-tracer experiments to simultaneously detect both15 N- and13 C-labeled metabolites in metabolic samples...
March 5, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29502941/nuclear-magnetic-resonance-and-gas-chromatography-mass-spectrometry-based-metabolomic-characterization-of-water-soluble-and-volatile-compound-profiles-in-cabbage-vinegar
#13
Satoru Ishihara, Takashi Inaoka, Toshihide Nakamura, Keitarou Kimura, Yasuyo Sekiyama, Satoru Tomita
Non-targeted metabolomic analyses employing nuclear magnetic resonance- and gas chromatography/mass spectrometry-based techniques were applied for an in-depth characterization of cabbage vinegar, an original agricultural product made from cabbage harvested in Tsumagoi, Japan. Water-soluble and volatile metabolite profiles of cabbage vinegar were compared with those of various vinegars: rice vinegar, grain vinegar, apple vinegar, and black vinegar (Japanese kurozu made of brown rice). Principal component analysis (PCA) of the water-soluble metabolites indicated that cabbage vinegars belonged to an isolated class by the contributions of fructose, pyroglutamic acid, choline, and methiin (S-methylcysteine sulfoxide)...
March 1, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29489838/susceptibility-and-tolerance-of-rice-crop-to-salt-threat-physiological-and-metabolic-inspections
#14
Nyuk Ling Ma, Wan Afifudeen Che Lah, Nisrin Abd Kadir, Mohamad Mustaqim, Zaidah Rahmat, Aziz Ahmad, Su Datt Lam, Mohd Razi Ismail
Salinity threat is estimated to reduce global rice production by 50%. Comprehensive analysis of the physiological and metabolite changes in rice plants from salinity stress (i.e. tolerant versus susceptible plants) is important to combat higher salinity conditions. In this study, we screened a total of 92 genotypes and selected the most salinity tolerant line (SS1-14) and most susceptible line (SS2-18) to conduct comparative physiological and metabolome inspections. We demonstrated that the tolerant line managed to maintain their water and chlorophyll content with lower incidence of sodium ion accumulation...
2018: PloS One
https://www.readbyqxmd.com/read/29453063/-1-h-nmr-based-metabolomics-reveals-interactive-effects-between-the-carrier-solvent-methanol-and-a-pharmaceutical-mixture-in-an-amphibian-developmental-bioassay-with-limnodynastes-peronii
#15
Steven D Melvin, Oliver A H Jones, Anthony R Carroll, Frederic D L Leusch
Organic carrier solvents are used in aquatic toxicity testing to improve chemical solubility and facilitate the exploration of dose-response relationships. Both water- and solvent-control groups are normally included in these scenarios to ensure that the solvent itself has no effect on the test organism, but this fails to consider possible interactive effects between carrier solvents and contaminants of interest. We explored this topic by exposing Limnodynastes peronii tadpoles to a mixture of common water-soluble pharmaceuticals (diclofenac, metformin and valproic acid) in the presence and absence of the carrier solvent methanol, according to standard developmental bioassay methodology...
February 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29433240/a-gc-ms-based-metabolomics-approach-to-determine-the-effect-of-salinity-on-kimchi
#16
Seung-Ho Seo, Seong-Eun Park, Eun-Ju Kim, Kyoung-In Lee, Chang-Su Na, Hong-Seok Son
GC-MS datasets coupled with multivariate statistical analysis were used to investigate metabolic changes in Kimchi during fermentation and metabolic differences in Kimchi added with various amounts (0, 1.25, 2.5, and 5%) of salts. PCA score plot obtained after 1day of fermentation were clearly distinguishable by different salinity groups, implying that early fermentation speed varied according to Kimchi salinity. PLS-DA score plot from data obtained on the 50th day of fermentation also showed a clear separation, indicating metabolites of Kimchi were different according to salinity...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29422013/first-and-second-trimester-urinary-metabolic-profiles-and-fetal-growth-restriction-an-exploratory-nested-case-control-study-within-the-infant-development-and-environment-study
#17
Gauri Luthra, Ivan Vuckovic, A Bangdiwala, H Gray, J B Redmon, E S Barrett, S Sathyanarayana, R H N Nguyen, S H Swan, S Zhang, P Dzeja, S I Macura, K S Nair
BACKGROUND: Routine prenatal care fails to identify a large proportion of women at risk of fetal growth restriction (FGR). Metabolomics, the comprehensive analysis of low molecular weight molecules (metabolites) in biological samples, can provide new and earlier biomarkers of prenatal health. Recent research has suggested possible predictive first trimester urine metabolites correlating to fetal growth restriction in the third trimester. Our objective in this current study was to examine urinary metabolic profiles in the first and second trimester of pregnancy in relation to third trimester FGR in a US population from a large, multi-center cohort study of healthy pregnant women...
February 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29421944/metabolomic-evaluation-of-euphorbia-pekinensis-induced-nephrotoxicity-in-rats
#18
Zhenzhen Liu, Yan Zeng, Pengyi Hou
CONTEXT: Euphorbia pekinensis Rupr. (Euphorbiaceae) has long been used in the Orient, while its clinical use was limited due to its nephrotoxic effect. OBJECTIVE: The possible mechanism of nephrotoxicity of Euphorbia pekinensis (EPR) and its related constituents were investigated. MATERIALS AND METHODS: Petroleum ether (PE), acetic ether (AE) and n-butanol (BUT) extracted sections of EPR were separately given to Wistar rats by gavage at the dose of 3 g/kg/day for 10 weeks to determine the nephrotoxic section of EPR...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29416446/urinary-metabolic-profiling-of-asymptomatic-acute-intermittent-porphyria-using-a-rule-mining-based-algorithm
#19
Margaux Luck, Caroline Schmitt, Neila Talbi, Laurent Gouya, Cédric Caradeuc, Hervé Puy, Gildas Bertho, Nicolas Pallet
Introduction: Metabolomic profiling combines Nuclear Magnetic Resonance spectroscopy with supervised statistical analysis that might allow to better understanding the mechanisms of a disease. Objectives: In this study, the urinary metabolic profiling of individuals with porphyrias was performed to predict different types of disease, and to propose new pathophysiological hypotheses. Methods: Urine1 H-NMR spectra of 73 patients with asymptomatic acute intermittent porphyria (aAIP) and familial or sporadic porphyria cutanea tarda (f/sPCT) were compared using a supervised rule-mining algorithm...
2018: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/29406718/metabolomics-analysis-reveals-that-ethylene-and-methyl-jasmonate-regulate-different-branch-pathways-to-promote-the-accumulation-of-terpenoid-indole-alkaloids-in-catharanthus-roseus
#20
Xiao-Ning Zhang, Jia Liu, Yang Liu, Yu Wang, Ann Abozeid, Zhi-Guo Yu, Zhong-Hua Tang
The medicinal plant Catharanthus roseus accumulates large numbers of terpenoid indole alkaloids (TIAs), including the pharmaceutically important vinblastine, vincristine, ajmalicine, and serpentine. The phytohormone ethylene or methyl jasmonate (MeJA) can markedly enhance alkaloid accumulation. The interaction between ethylene or MeJA in the regulation of TIA biosynthesis in C. roseus is unknown. Here, a metabolomics platform is reported that is based on liquid chromatography (LC) coupled with time-of-flight mass spectrometry to study candidate components for TIA biosynthesis, which is controlled by ethylene or MeJA in C...
February 6, 2018: Journal of Natural Products
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