keyword
https://read.qxmd.com/read/38546133/urine-tricarboxylic-acid-cycle-metabolites-and-risk-of-end-stage-kidney-disease-in-patients-with-type-2-diabetes
#1
JOURNAL ARTICLE
Jian-Jun Liu, Sylvia Liu, Huili Zheng, Janus Lee, Resham L Gurung, Clara Chan, Lye Siang Lee, Keven Ang, Jianhong Ching, Jean-Paul Kovalik, Subramaniam Tavintharan, Chee Fang Sum, Kumar Sharma, Thomas M Coffman, Su Chi Lim
CONTEXT: Metabolites in tricarboxylic acid (TCA) pathway have pleiotropic functions. OBJECTIVE: To study the association between urine TCA cycle metabolites and the risk for chronic kidney disease (CKD) progression in individuals with type 2 diabetes. DESIGN, SETTING AND PARTICIPANTS: A prospective study in a discovery (n = 1826) and a validation (n = 1235) cohort of type 2 diabetes in a regional hospital and a primary care facility...
March 28, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38540220/uremic-toxins-and-inflammation-metabolic-pathways-affected-in-non-dialysis-dependent-stage-5-chronic-kidney-disease
#2
JOURNAL ARTICLE
María Peris-Fernández, Marta Roca-Marugán, Julià L Amengual, Ángel Balaguer-Timor, Iris Viejo-Boyano, Amparo Soldevila-Orient, Ramon Devesa-Such, Pilar Sánchez-Pérez, Julio Hernández-Jaras
Chronic kidney disease (CKD) affects approximately 12% of the global population, posing a significant health threat. Inflammation plays a crucial role in the uremic phenotype of non-dialysis-dependent (NDD) stage 5 CKD, contributing to elevated cardiovascular and overall mortality in affected individuals. This study aimed to explore novel metabolic pathways in this population using semi-targeted metabolomics, which allowed us to quantify numerous metabolites with known identities before data acquisition through an in-house polar compound library...
March 7, 2024: Biomedicines
https://read.qxmd.com/read/38342423/a-landscape-of-metabolic-variation-among-clinical-outcomes-of-peritoneal-dialysis-in-end-stage-renal-disease
#3
JOURNAL ARTICLE
Ting Yang, Bangbang Wei, Jing Liu, Xinxin Si, Lulu Wang, Chunming Jiang
BACKGROUND: Peritoneal dialysis (PD) helps prevent lethal complications of end-stage renal disease (ESRD). However, the clinical outcomes are affected by PD-related complications. We investigated metabolic biomarkers to estimate the clinical outcomes of PD and identify patients at high risk of downstream complications and recurrent/relapsing infections. METHODS: Metabolites of normal control and ESRD patient were compared via an untargeted metabolomic analysis. Potential metabolic biomarkers were selected and quantified using a multiple reaction monitoring-based target metabolite detection method...
February 9, 2024: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/38266973/metabolites-associated-with-uremic-symptoms-in-patients-with-ckd-findings-from-the-chronic-renal-insufficiency-cohort-cric-study
#4
JOURNAL ARTICLE
Kendra E Wulczyn, Tariq Shafi, Amanda Anderson, Hernan Rincon-Choles, Clary B Clish, Michelle Denburg, Harold I Feldman, Jiang He, Chi-Yuan Hsu, Tanika Kelly, Paul L Kimmel, Rupal Mehta, Robert G Nelson, Vasan Ramachandran, Ana Ricardo, Vallabh O Shah, Anand Srivastava, Dawei Xie, Eugene P Rhee, Sahir Kalim
RATIONALE & OBJECTIVE: The toxins contributing to uremic symptoms in patients with CKD are unknown. We sought to apply complementary statistical modeling approaches to data from untargeted plasma metabolomic profiling to identify solutes associated with uremic symptoms in patients with CKD. STUDY DESIGN: Cross-sectional. SETTING & PARTICIPANTS: 1,761 Chronic Renal Insufficiency Cohort (CRIC) participants with CKD not on dialysis. PREDICTORS: Measurement of 448 known plasma metabolites...
January 22, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38244232/gut-flora-metagenomic-analysis-coupled-with-metabolic-and-deep-immune-profiling-in-chronic-kidney-disease
#5
JOURNAL ARTICLE
I-Wen Wu, Lun-Ching Chang, Yi-Lun Wu, Huang-Yu Yang, Yuh-Ching Twu, Po-Yu Tsai, Skyler Paulus, Rhian Resnick, Wen-Hung Chung, Chih-Wei Yang, Wen-Ping Hsieh, Shih-Chi Su
BACKGROUND AND HYPOTHESIS: Perturbation of gut microbiota has been linked to chronic kidney disease (CKD), which was correlated with a sophisticated milieu of metabolic and immune dysregulation. METHODS: To clarify the underlying host-microbe interaction in CKD, we performed multi-omics measurements, including systems-level gut microbiome, targeted serum metabolome, and deep immunotyping, in a cohort of patients and non-CKD controls. RESULTS: Our analyses on functional profiles of gut microbiome showed a decrease in the diversity and abundance of carbohydrate-active enzyme (CAZyme) genes but an increase in the abundance of antibiotic resistance, nitrogen cycling enzyme, and virulence factor genes in CKD...
January 19, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38089059/integrated-metabolomics-and-proteomics-reveal-biomarkers-associated-with-hemodialysis-in-end-stage-kidney-disease
#6
JOURNAL ARTICLE
Weiwei Lin, Fatemeh Mousavi, Benjamin C Blum, Christian F Heckendorf, Jarrod Moore, Noah Lampl, Mark McComb, Sergei Kotelnikov, Wenqing Yin, Nabil Rabhi, Matthew D Layne, Dima Kozakov, Vipul C Chitalia, Andrew Emili
Background: We hypothesize that the poor survival outcomes of end-stage kidney disease (ESKD) patients undergoing hemodialysis are associated with a low filtering efficiency and selectivity. The current gold standard criteria using single or several markers show an inability to predict or disclose the treatment effect and disease progression accurately. Methods: We performed an integrated mass spectrometry-based metabolomic and proteomic workflow capable of detecting and quantifying circulating small molecules and proteins in the serum of ESKD patients...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37920777/precision-medicine-in-diabetic-kidney-disease-a-narrative-review-framed-by-lived-experience
#7
REVIEW
Mallory L Downie, Arlene Desjarlais, Nancy Verdin, Tania Woodlock, David Collister
PURPOSE OF REVIEW: Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease (CKD) for which many treatments exist that have been shown to prevent CKD progression and kidney failure. However, DKD is a complex and heterogeneous etiology of CKD with a spectrum of phenotypes and disease trajectories. In this narrative review, we discuss precision medicine approaches to DKD, including genomics, metabolomics, proteomics, and their potential role in the management of diabetes mellitus and DKD...
2023: Canadian Journal of Kidney Health and Disease
https://read.qxmd.com/read/37752301/evaluation-of-amino-acids-and-other-related-metabolites-levels-in-end-stage-renal-disease-esrd-patients-on-hemodialysis-by-lc-ms-ms-and-gc-ms
#8
JOURNAL ARTICLE
Pavankumar Pallerla, Nagarjunachary Ragi, Aravind Reddy Babi Reddy Gari, Sudarshana Reddy Bhumireddy, Ramunaidu Addipilli, Ramesh Rodda, Manjusha Yadla, Prabhakar Sripadi
End-stage renal disease (ESRD) is a rapidly increasing health problem, and every year, about 2 million ESRD cases are reported worldwide. Hemodialysis (HD) is the vital renal reinstatement therapy for ESRD, and HD patterns play a crucial role in patients' health. Plasma metabolomics is the potential approach to understanding the HD process, effectiveness, and patterns. The lack of protein vitality is a primary problem for HD patients, and the quantities of amino acids intracellularly and in the blood are considered to be a symbolic index of protein metabolism and nutrition conditions...
November 2023: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/37512544/exploration-of-potential-breath-biomarkers-of-chronic-kidney-disease-through-thermal-desorption-gas-chromatography-mass-spectrometry
#9
JOURNAL ARTICLE
Si-Hyun Seong, Hyun Sik Kim, Yong-Moon Lee, Jae-Seok Kim, Sangwoo Park, Jieun Oh
Breath volatile organic compound (VOC) analysis is a non-invasive tool for assessing health status; the compositional profile of these compounds in the breath of patients with chronic kidney disease is believed to change with decreasing renal function. We aimed to identify breath VOCs for recognizing patients with chronic kidney disease. Using thermal desorption-gas chromatography/mass spectrometry, untargeted analysis of breath markers was performed using breath samples of healthy controls ( n = 18) versus non-dialysis ( n = 21) and hemodialysis ( n = 12) patients with chronic kidney disease in this cross-sectional study...
July 11, 2023: Metabolites
https://read.qxmd.com/read/37512502/effects-of-exercise-on-inflammatory-markers-in-individuals-with-chronic-kidney-disease-a-systematic-review-and-meta-analysis
#10
REVIEW
Victor M Baião, Vinícius A Cunha, Marvery P Duarte, Francini P Andrade, Aparecido P Ferreira, Otávio T Nóbrega, João L Viana, Heitor S Ribeiro
Individuals with chronic kidney disease (CKD) have a systemic inflammatory state. We assessed the effects of exercise on inflammatory markers in individuals with CKD. An electronic search was conducted, including MEDLINE. Experimental clinical trials that investigated the effects of exercise on inflammatory markers in individuals with CKD at all stages were included. Meta-analyses were conducted using the random-effects model and standard mean difference (SMD). Subgroup analyses were performed for resistance, aerobic, and combined exercise interventions...
June 27, 2023: Metabolites
https://read.qxmd.com/read/37373777/metabolomics-in-acute-kidney-injury-the-clinical-perspective
#11
REVIEW
Daniel Patschan, Susann Patschan, Igor Matyukhin, Oliver Ritter, Werner Dammermann
BACKGROUND: Acute kidney injury (AKI) affects increasing numbers of hospitalized patients worldwide. The diagnosis of AKI is made too late in most individuals since it is still based on dynamic changes in serum creatinine. In recent years, new AKI biomarkers have been identified; however, none of these can reliably replace serum creatinine yet. Metabolomic profiling (metabolomics) allows the concomitant detection and quantification of large numbers of metabolites from biological specimens...
June 16, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37238723/the-effects-of-two-kinds-of-dietary-interventions-on-serum-metabolic-profiles-in-haemodialysis-patients
#12
JOURNAL ARTICLE
Lucyna Kozlowska, Karolina Jagiello, Krzesimir Ciura, Anita Sosnowska, Rafal Zwiech, Zbigniew Zbrog, Wojciech Wasowicz, Jolanta Gromadzinska
The goal of this study was to evaluate the effects of two kinds of 24-week dietary interventions in haemodialysis patients, a traditional nutritional intervention without a meal before dialysis (HG1) and implementation of a nutritional intervention with a meal served just before dialysis (HG2), in terms of analysing the differences in the serum metabolic profiles and finding biomarkers of dietary efficacy. These studies were performed in two homogenous groups of patients (n = 35 in both groups). Among the metabolites with the highest statistical significance between HG1 and HG2 after the end of the study, 21 substances were putatively annotated, which had potential significance in both of the most relevant metabolic pathways and those related to diet...
May 18, 2023: Biomolecules
https://read.qxmd.com/read/37159264/randomized-crossover-clinical-trial-of-coenzyme-q10-and-nicotinamide-ribosome-in-chronic-kidney-disease
#13
JOURNAL ARTICLE
Armin Ahmadi, Gwenaelle Begue, Ana P Valencia, Jennifer E Norman, Benjamin Lidgard, Brian J Bennett, Matthew P Van Doren, David J Marcinek, Sili Fan, David K Prince, Jorge L Gamboa, Jonathan Himmelfarb, Ian H de Boer, Bryan R Kestenbaum, Baback Roshanravan
BACKGROUND: Current studies suggest mitochondrial dysfunction is a major contributor to impaired physical performance and exercise intolerance in chronic kidney disease (CKD). We conducted a clinical trial of coenzyme Q10 (CoQ10) and nicotinamide riboside (NR) to determine their impact on exercise tolerance and metabolic profile in CKD patients. METHODS: We conducted a randomized placebo-controlled, double blind, cross-over trial comparing CoQ10, NR, and placebo in 25 patients with eGFR of <60ml/min/1...
May 9, 2023: JCI Insight
https://read.qxmd.com/read/37121932/csf-metabolomics-alterations-after-aneurysmal-subarachnoid-hemorrhage-what-do-we-know
#14
REVIEW
Wing Mann Ho, Franziska A Schmidt, Claudius Thomé, Ondra Petr
PURPOSE: The purpose of this mini review is to describe metabolomics in cerebrospinal fluid (CSF) and its potential in aneurysmal subarachnoid hemorrhage (aSAH). In brain injury, patients' micro dialysis enables detecting biochemical change in brain tissue. Indicators for ischemia were detected such as lactate, pyruvate, glucose, and glutamate. In aSAH patients, the pathophysiology and the factor for poor outcome are not completely understood yet. Routine use of biomarkers in CSF, particularly in aSAH patients, is still lacking...
April 30, 2023: Acta Neurologica Belgica
https://read.qxmd.com/read/37116716/biomolecular-map-of-albumin-identifies-signatures-of-severity-and-early-mortality-in-acute-liver-failure
#15
JOURNAL ARTICLE
Neha Sharma, Sushmita Pandey, Manisha Yadav, Babu Mathew, Vasundhra Bindal, Nupur Sharma, Gaurav Tripathi, Sadam H Bhat, Abhishak Gupta, Rakhi Maiwall, Shvetank Sharma, Shiv Kumar Sarin, Jaswinder Singh Maras
BACKGROUND & AIMS: Acute liver failure (ALF) is associated with high mortality. Alterations in albumin structure and function have been shown to correlate with outcomes in cirrhosis. We undertook a biomolecular analysis of albumin to determine its correlation with hepatocellular injury and early mortality in ALF. METHODS: Altogether, 225 participants (200 patients with ALF and 25 healthy controls [HC]) were enrolled. Albumin was purified from the baseline plasma of the training cohort (ALF, n = 40; survivors, n = 8; non-survivors, n = 32; and HC, n = 5); analysed for modifications, functionality, and bound multi-omics signatures; and validated in a test cohort (ALF, n = 160; survivors, n = 53; non-survivors, n = 107; and HC, n = 20)...
September 2023: Journal of Hepatology
https://read.qxmd.com/read/37061630/metabolomics-profiling-distinctively-identified-end-stage-renal-disease-patients-from-chronic-kidney-disease-patients
#16
JOURNAL ARTICLE
Lina A Dahabiyeh, Refat M Nimer, Khalid M Sumaily, Mohamad S Alabdaljabar, Minnie Jacob, Essa M Sabi, Maged H Hussein, Anas Abdel Rahman
Chronic kidney disease (CKD) is a serious public health problem characterized by progressive kidney function loss leading to end-stage renal disease (ESRD) that demands dialysis or kidney transplantation. Early detection can prevent or delay progression to ESRD. The study aimed to gain new insights into the perturbed biochemical reactions and to identify novel distinct biomarkers between ESRD and CKD. Serum samples of 32 patients with ESRD (n = 13) and CKD (n = 19) were analyzed using chemical isotope labeling liquid chromatography-mass spectrometry metabolomics approach...
April 15, 2023: Scientific Reports
https://read.qxmd.com/read/37051665/serum-metabolic-alterations-in-peritoneal-dialysis-patients-with-excessive-daytime-sleepiness
#17
JOURNAL ARTICLE
Wei Chen, Ying Xu, Zheng-Hao Li, Ya-Chen Si, Hai-Yan Wang, Xiao-Lu Bian, Lu Li, Zhi-Yong Guo, Xue-Li Lai
Excessive daytime sleepiness (EDS) is associated with quality of life and all-cause mortality in the end-stage renal disease population. This study aims to identify biomarkers and reveal the underlying mechanisms of EDS in peritoneal dialysis (PD) patients. A total of 48 nondiabetic continuous ambulatory peritoneal dialysis patients were assigned to the EDS group and the non-EDS group according to the Epworth Sleepiness Scale (ESS). Ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) was used to identify the differential metabolites...
December 2023: Renal Failure
https://read.qxmd.com/read/36903372/characterization-and-biological-activities-of-in-vitro-digested-olive-pomace-polyphenols-evaluated-on-ex-vivo-human-immune-blood-cells
#18
JOURNAL ARTICLE
Claudio Alimenti, Mariacaterina Lianza, Fabiana Antognoni, Laura Giusti, Onelia Bistoni, Luigi Liotta, Cristina Angeloni, Giulio Lupidi, Daniela Beghelli
Olive pomace (OP) represents one of the main by-products of olive oil production, which still contains high quantities of health-promoting bioactive compounds. In the present study, three batches of sun-dried OP were characterized for their profile in phenolic compounds (by HPLC-DAD) and in vitro antioxidant properties (ABTS, FRAP and DPPH assays) before (methanolic extracts) and after (aqueous extracts) their simulated in vitro digestion and dialysis. Phenolic profiles, and, accordingly, the antioxidant activities, showed significant differences among the three OP batches, and most compounds showed good bioaccessibility after simulated digestion...
February 24, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36882429/metabolomic-profiling-of-overnight-peritoneal-dialysis-effluents-predicts-the-peritoneal-equilibration-test-type
#19
JOURNAL ARTICLE
Hyo Jin Kim, Munki Choo, Hyuk Nam Kwon, Kyung Don Yoo, Yunmi Kim, Bodokhsuren Tsogbadrakh, Eunjeong Kang, Sunghyouk Park, Kook-Hwan Oh
This study primarily aimed to evaluate whether peritoneal equilibration test (PET) results can be predicted through the metabolomic analysis of overnight peritoneal dialysis (PD) effluents. From a total of 125 patients, overnight PD effluents on the day of the first PET after PD initiation were analyzed. A modified 4.25% dextrose PET was performed, and the PET type was categorized according to the dialysate-to-plasma creatinine ratio at the 4-h dwell time during the PET as follows: high, high average, low average, or low transporter...
March 7, 2023: Scientific Reports
https://read.qxmd.com/read/36837922/association-of-red-blood-cell-distribution-width-and-neutrophil-to-lymphocyte-ratio-with-calcification-and-cardiovascular-markers-in-chronic-kidney-disease
#20
JOURNAL ARTICLE
Stefanos Roumeliotis, Ioannis E Neofytou, Cecile Maassen, Petra Lux, Konstantia Kantartzi, Evangelos Papachristou, Leon J Schurgers, Vassilios Liakopoulos
We aimed to investigate the association between Red Blood Cell Distribution Width (RDW) and Neutrophil-to-Lymphocyte Ratio (NLR), simple, rapidly assessed markers from the complete blood count with vascular calcification (VC)/stiffness and cardiovascular disease (CVD) in chronic kidney disease (CKD). Dephosphorylated, uncarboxylated matrix Gla-protein (dp-ucMGP), and central/peripheral hemodynamics' parameters were measured in 158 CKD patients, including Hemodialysis and Peritoneal Dialysis. Spearman's rho analysis showed that RDW correlated with C-reactive protein (CRP) (r = 0...
February 17, 2023: Metabolites
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