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Metabolomic dialysis

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https://www.readbyqxmd.com/read/27768727/addition-of-alanyl-glutamine-to-dialysis-fluid-restores-peritoneal-cellular-stress-responses-a-first-in-man-trial
#1
Klaus Kratochwill, Michael Boehm, Rebecca Herzog, Katharina Gruber, Anton Michael Lichtenauer, Lilian Kuster, Dagmar Csaicsich, Andreas Gleiss, Seth L Alper, Christoph Aufricht, Andreas Vychytil
BACKGROUND: Peritonitis and ultrafiltration failure remain serious complications of chronic peritoneal dialysis (PD). Dysfunctional cellular stress responses aggravate peritoneal injury associated with PD fluid exposure, potentially due to peritoneal glutamine depletion. In this randomized cross-over phase I/II trial we investigated cytoprotective effects of alanyl-glutamine (AlaGln) addition to glucose-based PDF. METHODS: In a prospective randomized cross-over design, 20 stable PD outpatients underwent paired peritoneal equilibration tests 4 weeks apart, using conventional acidic, single chamber 3...
2016: PloS One
https://www.readbyqxmd.com/read/27221201/changes-in-serum-metabolites-with-the-stage-of-chronic-kidney-disease-comparison-of-diabetes-and-non-diabetes
#2
Jueun Lee, Ji-Young Choi, Yong-Kook Kwon, Doohae Lee, Hee-Yeon Jung, Hye-Myung Ryu, Jang-Hee Cho, Do Hyun Ryu, Yong-Lim Kim, Geum-Sook Hwang
BACKGROUND: The renal dysfunction of chronic kidney disease (CKD) alters serum metabolite levels, but it is not clear how diabetes mellitus (DM) affects the metabolic changes in CKD. METHODS: Serum metabolites from pre-dialysis CKD patients (n=291) with or without DM and from healthy controls (n=56) was measured using nuclear magnetic resonance. RESULTS: Initial principal components analysis and partial least squares-discriminant analysis score plots segregated the CKD patients according to CKD stage and separated DM from non-DM patients...
August 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/26698225/the-sapienza-university-mortality-and-morbidity-event-rate-summer-study-in-diabetes-study-protocol
#3
I Barchetta, D Capoccia, M G Baroni, R Buzzetti, M G Cavallo, S De Cosmo, F Leonetti, S Leotta, S Morano, L Morviducci, S Prudente, G Pugliese, V Trischitta
BACKGROUND AND AIMS: The rate of mortality in diabetic patients, especially of cardiovascular origin, is about twice as much that of nondiabetic individuals. Thus, the pathogenic factors shaping the risk of mortality in such patients must be unraveled in order to target intensive prevention and treatment strategies. The "Sapienza University Mortality and Morbidity Event Rate (SUMMER) study in diabetes" is aimed at identifying new molecular promoters of mortality and major vascular events in patients with type 2 diabetes mellitus (T2DM)...
February 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/26521655/newest-strategies-in-the-search-for-bioactive-saponins-from-the-tropical-plant-biodiversity
#4
Marie-Aleth Lacaille-Dubois
This review will focus on newest results leading to the discovery of new bioactive saponins by using a combination of successive advanced procedures in extraction, isolation, structure elucidation and bioassays. Microwave- and ultrasonic-assisted extractions, two recent advanced methods have been increasingly used in the last decade. Then, a multistep purification procedure was achieved by flash chromatography, vacuum liquid chromatography, low, medium- and high-pressure liquid chromatography on silica gel and reversed-phase silica gel RP-18 (VLC, LPLC, MPLC, HPLC)...
2016: Current Drug Delivery
https://www.readbyqxmd.com/read/26149577/cross-sectional-examination-of-metabolites-and-metabolic-phenotypes-in-uremia
#5
Sahir Kalim, Clary B Clish, Joseph J Deferio, Guillermo Ortiz, Alexander S Moffet, Robert E Gerszten, Ravi Thadhani, Eugene P Rhee
BACKGROUND: Although metabolomic approaches have begun to document numerous changes that arise in end stage renal disease (ESRD), how these alterations relate to established metabolic phenotypes in uremia is unknown. METHODS: In 200 incident hemodialysis patients we used partial least squares discriminant analysis to identify which among 166 metabolites could best discriminate individuals with or without diabetes, and across tertiles of body mass index, serum albumin, total cholesterol, and systolic blood pressure...
July 7, 2015: BMC Nephrology
https://www.readbyqxmd.com/read/26015416/peritoneal-dialysis-nanoparticles-have-entered-the-game
#6
EDITORIAL
Olivier Devuyst, Anke Schumann
No abstract text is available yet for this article.
May 2015: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/25755835/activation-of-the-calcium-sensing-receptor-before-renal-ischemia-reperfusion-exacerbates-kidney-injury
#7
Laurent Weekers, Pascal de Tullio, Christophe Bovy, Laurence Poma, Raphaël Marée, Catherine Bonvoisin, Jean-Olivier Defraigne, Jean-Marie Krzesinski, François Jouret
Activation of the calcium-sensing receptor (CaSR) by ischemia/reperfusion (I/R) favours apoptosis in cardiomyocytes, hepatocytes and neurons. Its role in renal I/R is unknown. We investigated the impact of pharmacological preactivation of the CaSR on kidney structure and function in a murine model of bilateral renal 30-min ischemia and 48-hour reperfusion, and in a 6-year cohort of kidney transplant recipients (KTR). C57BL/6J mice were administered daily with CaSR agonist, R-568, or with vehicle for 48 hours...
2015: American Journal of Translational Research
https://www.readbyqxmd.com/read/25441338/new-methods-and-technologies-for-measuring-uremic-toxins-and-quantifying-dialysis-adequacy
#8
REVIEW
Raymond Vanholder, Jente Boelaert, Griet Glorieux, Sunny Eloot
This publication reviews the currently available methods to identify uremic retention solutes, to determine their biological relevance and to quantify their removal. The analytical methods for the detection of uremic solutes have improved continuously, allowing the identification of several previously unknown solutes. Progress has been accelerated by the development of comprehensive strategies such as genomics, proteomics and the latest "omics" area, metabolomics. Those methodologies will be further refined in future...
March 2015: Seminars in Dialysis
https://www.readbyqxmd.com/read/25320233/liposome-supported-peritoneal-dialysis-for-detoxification-of-drugs-and-endogenous-metabolites
#9
Vincent Forster, Rea Deborah Signorell, Maurizio Roveri, Jean-Christophe Leroux
Peritoneal dialysis confers therapeutic advantages in patients with renal insufficiency and has proven beneficial in other indications, such as removal of excess metabolites or overdosed drugs. However, it is used in only about 10% of the dialyzed population worldwide, partly owing to the lower clearance rate compared with hemodialysis. We have developed a dialysis medium based on liposomes with a transmembrane pH gradient (basic or acidic aqueous core) that could improve the efficacy of peritoneal dialysis, specifically for the removal of excess metabolites or overdosed drugs...
October 15, 2014: Science Translational Medicine
https://www.readbyqxmd.com/read/25164824/extending-the-spectrum-of-%C3%AE-dicarbonyl-compounds-in-vivo
#10
Christian Henning, Kristin Liehr, Matthias Girndt, Christof Ulrich, Marcus A Glomb
Maillard α-dicarbonyl compounds are known as central intermediates in advanced glycation end product (AGE) formation. Glucose is the primary source of energy for the human body, whereas l-threo-ascorbic acid (vitamin C) is an essential nutrient, involved in a variety of enzymatic reactions. Thus, the Maillard degradation of glucose and ascorbic acid is of major importance in vivo. To understand the complex mechanistic pathways of AGE formation, it is crucial to extend the knowledge on plasma concentrations of reactive key α-dicarbonyl compounds (e...
October 10, 2014: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/24780472/proteomics-and-metabolomics-as-tools-to-unravel-novel-culprits-and-mechanisms-of-uremic-toxicity-instrument-or-hype
#11
REVIEW
William Mullen, Daisuke Saigusa, Takaaki Abe, Jerzy Adamski, Harald Mischak
The development of proteomic and metabolomic technologies holds the promise to significantly impact patient management by improving diagnosis, unraveling more appropriate therapeutic targets, and enabling more precise prognosis of disease development. Proteomics and metabolomics have been applied with the aim of improving dialysis, defining uremic toxins, and unraveling their origin. Ideally, these technologies should inform us which proteomic or metabolomic compounds are subject to significant alterations of concentration or structure as a result of failing kidney function, and thus can be considered as potential uremic toxins...
March 2014: Seminars in Nephrology
https://www.readbyqxmd.com/read/24308938/a-plasma-long-chain-acylcarnitine-predicts-cardiovascular-mortality-in-incident-dialysis-patients
#12
Sahir Kalim, Clary B Clish, Julia Wenger, Sammy Elmariah, Robert W Yeh, Joseph J Deferio, Kerry Pierce, Amy Deik, Robert E Gerszten, Ravi Thadhani, Eugene P Rhee
BACKGROUND: The marked excess in cardiovascular mortality that results from uremia remains poorly understood. METHODS AND RESULTS: In 2 independent, nested case-control studies, we applied liquid chromatography-mass spectrometry-based metabolite profiling to plasma obtained from participants of a large cohort of incident hemodialysis patients. First, 100 individuals who died of a cardiovascular cause within 1 year of initiating hemodialysis (cases) were randomly selected along with 100 individuals who survived for at least 1 year (controls), matched for age, sex, and race...
2013: Journal of the American Heart Association
https://www.readbyqxmd.com/read/24235289/plasma-and-urinary-amino-acid-metabolomic-profiling-in-patients-with-different-levels-of-kidney-function
#13
MULTICENTER STUDY
Flore Duranton, Ulrika Lundin, Nathalie Gayrard, Harald Mischak, Michel Aparicio, Georges Mourad, Jean-Pierre Daurès, Klaus M Weinberger, Angel Argilés
BACKGROUND AND OBJECTIVES: Patients with CKD display altered plasma amino acid profiles. This study estimated the association between the estimated GFR and urinary and plasma amino acid profiles in CKD patients. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Urine and plasma samples were taken from 52 patients with different stages of CKD, and plasma samples only were taken from 25 patients on maintenance hemodialysis. Metabolic profiling was performed by liquid chromatography coupled with tandem mass spectrometry after phenylisothiocyanate derivatization...
January 2014: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/23940749/uremic-pruritus-dialysis-adequacy-and-metabolic-profiles-in-hemodialysis-patients-a-prospective-5-year-cohort-study
#14
Mei-Ju Ko, Hon-Yen Wu, Hung-Yuan Chen, Yen-Ling Chiu, Shih-Ping Hsu, Mei-Fen Pai, Ju-Yehyang, Chun-Fu Lai, Hui-Min Lu, Shu-Chen Huang, Shao-Yu Yang, Su-Yin Wen, Hsien-Ching Chiu, Fu-Chang Hu, Yu-Sen Peng, Shiou-Hwa Jee
BACKGROUND: Uremic pruritus is a common and intractable symptom in patients on chronic hemodialysis, but factors associated with the severity of pruritus remain unclear. This study aimed to explore the associations of metabolic factors and dialysis adequacy with the aggravation of pruritus. METHODS: We conducted a 5-year prospective cohort study on patients with maintenance hemodialysis. A visual analogue scale (VAS) was used to assess the intensity of pruritus...
2013: PloS One
https://www.readbyqxmd.com/read/23936492/optimized-metabolomic-approach-to-identify-uremic-solutes-in-plasma-of-stage-3-4-chronic-kidney-disease-patients
#15
COMPARATIVE STUDY
Henricus A M Mutsaers, Udo F H Engelke, Martijn J G Wilmer, Jack F M Wetzels, Ron A Wevers, Lambertus P van den Heuvel, Joost G Hoenderop, Rosalinde Masereeuw
BACKGROUND: Chronic kidney disease (CKD) is characterized by the progressive accumulation of various potential toxic solutes. Furthermore, uremic plasma is a complex mixture hampering accurate determination of uremic toxin levels and the identification of novel uremic solutes. METHODS: In this study, we applied (1)H-nuclear magnetic resonance (NMR) spectroscopy, following three distinct deproteinization strategies, to determine differences in the plasma metabolic status of stage 3-4 CKD patients and healthy controls...
2013: PloS One
https://www.readbyqxmd.com/read/23690958/ckd273-a-new-proteomics-classifier-assessing-ckd-and-its-prognosis
#16
Ángel Argilés, Justyna Siwy, Flore Duranton, Nathalie Gayrard, Mohammed Dakna, Ulrika Lundin, Lourdes Osaba, Christian Delles, Georges Mourad, Klaus M Weinberger, Harald Mischak
National Kidney Foundation CKD staging has allowed uniformity in studies on CKD. However, early diagnosis and predicting progression to end stage renal disease are yet to be improved. Seventy six patients with different levels of CKD, including outpatients and dialysed patients were studied for transcriptome, metabolome and proteome description. High resolution urinary proteome analysis was blindly performed in the 53 non-anuric out of the 76 CKD patients. In addition to routine clinical parameters, CKD273, a urinary proteomics-based classifier and its peptides were quantified...
2013: PloS One
https://www.readbyqxmd.com/read/22890273/toward-personalized-hemodialysis-by-low-molecular-weight-amino-containing-compounds-future-perspective-of-patient-metabolic-fingerprint
#17
Vittorio Sirolli, Claudia Rossi, Augusto Di Castelnuovo, Paolo Felaco, Luigi Amoroso, Mirco Zucchelli, Domenico Ciavardelli, Carmine Di Ilio, Paolo Sacchetta, Sergio Bernardini, Arduino Arduini, Mario Bonomini, Andrea Urbani
BACKGROUND: L-carnitine deficiency is commonly observed in chronic hemodialysis patients, and this depletion may cause clinical symptoms like muscle weakness, anaemia, and hypotension. MATERIALS AND METHODS: We pursued a targeted metabonomics investigation in 28 hemodialysis patients (13 non diabetics and 15 diabetics) and in 10 age-matched healthy controls, on plasma levels of all carnitine esters and of several amino acids. Samples were taken before and after the first hemodialysis treatment of the week...
May 2012: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/22294777/proof-of-principle-study-to-detect-metabolic-changes-in-peritoneal-dialysis-effluent-in-patients-who-develop-encapsulating-peritoneal-sclerosis
#18
Warwick B Dunn, Angela Summers, Marie Brown, Royston Goodacre, Mark Lambie, Tim Johnson, Martin Wilkie, Simon Davies, Nick Topley, Paul Brenchley
BACKGROUND: Prolonged peritoneal dialysis (PD) therapy can result in the development of encapsulating peritoneal sclerosis (EPS), characterized by extensive sclerosis of the peritoneum with bowel adhesions often causing obstruction. METHODS: As a proof-of-principle study, holistic profiling of endogenous metabolites has been applied in a prospective collection of PD effluent collected in multiple UK renal centres over 6 years in order to investigate metabolic differences in PD effluent between PD therapy patients who later developed clinically defined EPS (n = 11) and controls, who were matched for PD vintage, age and gender (n = 11)...
June 2012: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/22122470/revealing-the-allosterome-systematic-identification-of-metabolite-protein-interactions
#19
Thomas Orsak, Tammy L Smith, Debbie Eckert, Janet E Lindsley, Chad R Borges, Jared Rutter
Small molecule allostery modifies protein function but is not easily discovered. We introduce mass spectrometry integrated with equilibrium dialysis for the discovery of allostery systematically (MIDAS), a method for identifying physiologically relevant, low-affinity metabolite-protein interactions using unmodified proteins and complex mixtures of unmodified metabolites. In a pilot experiment using five proteins, we identified 16 known and 13 novel interactions. The known interactions included substrates, products, intermediates, and allosteric regulators of their protein partners...
January 10, 2012: Biochemistry
https://www.readbyqxmd.com/read/21974638/complex-networks-analysis-of-obstructive-nephropathy-data
#20
M Zanin, S Boccaletti
Congenital obstructive nephropathy (ON) is one of the most frequent nephropathy observed among newborns and children, and the first cause of end-stage renal diseases treated by dialysis or transplantation. This pathology is characterized by the presence of an obstacle in the urinary tract, e.g., stenosis or abnormal implantation of the urethra in the kidney. In spite of important advances, pathological mechanisms are not yet fully understood. In this contribution, the topology of complex networks created upon vectors of features for control and ON subjects is related with the severity of the pathology...
September 2011: Chaos
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