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https://www.readbyqxmd.com/read/29456505/deletion-of-trace-amine-associated-receptor-1-attenuates-behavioral-responses-to-caffeine
#1
Michael D Schwartz, Jeremiah B Palmerston, Diana L Lee, Marius C Hoener, Thomas S Kilduff
Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a GPCR that modulates dopaminergic, serotonergic, and glutamatergic activity. Selective TAAR1 full and partial agonists exhibit similar pro-cognitive, antidepressant- and antipsychotic-like properties in rodents and non-human primates, suggesting TAAR1 as a novel target for the treatment of neurological and psychiatric disorders. We previously reported that TAAR1 partial agonists are wake-promoting in rats and mice, and that TAAR1 knockout (KO) and overexpressing mice exhibit altered sleep-wake and EEG spectral composition...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29452814/deep-or-awake-removal-of-laryngeal-mask-airway-in-children-at-risk-of-respiratory-adverse-events-undergoing-tonsillectomy-a-randomised-controlled-trial
#2
A Ramgolam, G L Hall, G Zhang, M Hegarty, B S von Ungern-Sternberg
BACKGROUND: Laryngeal mask airways (LMA) are widely used during tonsillectomies. Contrasting evidence exists regarding the timing of the removal and the risk of perioperative respiratory adverse events. We assessed whether the likelihood of perioperative respiratory adverse events is influenced by the timing of LMA removal in children with at least one risk factor for these events. METHODS: Participants (n=290, 0-16 yr) were randomised to have their LMA removed either deep (in theatre by anaesthetist at end-tidal sevoflurane >1 minimum alveolar concentration) or awake (in theatre by anaesthetist or in postanaesthesia care unit by anaesthetist or trained nurse)...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29441173/a-comparison-of-i-gel%C3%A2-and-laryngeal-mask-airway-supreme%C3%A2-during-general-anesthesia-in-infants
#3
Yoon Chan Lee, Kyoung Seop Yoon, Sang Yoong Park, So Ron Choi, Chan Jong Chung
Background: The i-gel™ (i-gel) and Laryngeal Mask Airway Supreme™ (LMA Supreme) have been safely used in children. We compared the airway performance of the i-gel and LMA Supreme in infants undergoing general anesthesia. Methods: Sixty infants with American Society of Anesthesiologists physical status I or II were randomly assigned to place either the i-gel or the LMA Supreme. The size 1 or 1.5 of each airway was selected by the weight of infants. The primary outcome variable was oropharyngeal leak pressure (OLP)...
February 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29429688/a-simple-approach-for-the-sonochemical-loading-of-au-ag-and-pd-nanoparticle-on-functionalized-mwcnt-and-subsequent-dispersion-studies-for-removal-of-organic-dyes-artificial-neural-network-and-response-surface-methodology-studies
#4
Mitra Moghaddari, Fakhri Yousefi, Mehrorang Ghaedi, Kheibar Dashtian
In this study, the artificial neural network (ANN) and response surface methodology (RSM) based on central composite design (CCD) were applied for modeling and optimization of the simultaneous ultrasound-assisted removal of quinoline yellow (QY) and eosin B (EB). The MWCNT-NH2 and its composites were prepared by sonochemistry method and characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and energy dispersive spectroscopy (EDS) analysis's. Initial dyes concentrations, adsorbent mass, sonication time and pH contribution on QY and EB removal percentage were investigated by CCD and replication of experiments at conditions suggested by model has results which statistically are close to experimented data...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29417920/emergency-airway-management-in-a-simulation-of-highly-contagious-isolated-patients-both-isolation-strategy-and-device-type-matter
#5
Eike Plazikowski, Robert Greif, Jonas Marschall, Tina H Pedersen, Maren Kleine-Brueggeney, Roland Albrecht, Lorenz Theiler
OBJECTIVE To compare 6 airway-management devices in 3 isolation scenarios regarding their effect on airway management: portable isolation unit (PIU), personal protective equipment (PPE), and standard protection measures METHODS In total, 30 anesthesiologists working in emergency medical services performed airway management on mannequins in 3 isolation settings using 6 different airway management devices (in random order): (1) standard Macintosh laryngoscope; (2) Airtraq SP-video-laryngoscope; (3) i-gel; (4) LMA-Fastrach; (5) Ambu fiberoptic-aScope; and (6) Melker cricothyrotomy-set...
February 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29416239/tracheal-intubation-through-laryngeal-mask-airway-ctrach%C3%A2-with-polyvinyl-chloride-tube-comparison-between-two-orientations-of-the-tracheal-tube
#6
Karri Pavani, Handattu Mahabaleswara Krishna, Joseph Nandhini
Background and Aims: Higher success rate of intubation is observed with the reverse orientation of polyvinyl chloride (PVC) tracheal tube while intubating through laryngeal mask airway (LMA) Fastrach™. It is not clear whether the same is true during intubation through LMA CTrach™ visualizing the process of intubation. The primary aim of this study was to compare the influence of the PVC tracheal tube orientation on the success rate of intubation while intubating through LMA CTrach™...
October 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29416238/i-gel-versus-laryngeal-mask-airway-lma-classic-as-a-conduit-for-tracheal-intubation-using-ventilating-bougie
#7
Aditi A Dhimar, Bhavika R Sangada, Mahendra R Upadhyay, Sangita H Patel
Background and Aims: Supraglottic airways (SGAs) are generally used for airway management; but can also be used as a conduit for tracheal intubation. Our primary aim was to evaluate i-Gel and laryngeal mask airway (LMA) classic as conduits for tracheal intubation using ventilating bougie by assessing number of attempts and time for insertion of SGAs, ventilating bougie and endotracheal tube (ETT), and total intubation time. Material and Methods: A randomized clinical trial was carried out in 58 patients requiring general anesthesia and endotracheal intubation for planned surgery...
October 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29413458/long-term-biodistribution-study-of-hpma-ran-lma-copolymers-in-vivo-by-means-of-131i-labeling
#8
Karolin Wagener, Dorothea Moderegger, Mareli Allmeroth, Achim Reibel, Stefan Kramer, Barbara Biesalski, Nicole Bausbacher, Rudolf Zentel, Oliver Thews, Frank Rösch
BACKGROUND: For the evaluation of macromolecular drug delivery systems suitable pre-clinical monitoring of potential nanocarrier systems is needed. In this regard, both short-term as well as long-term in vivo tracking is crucial to understand structure-property relationships of polymer carrier systems and their resulting pharmacokinetic profile. Based on former studies revealing favorable in vivo characteristics for 18F-labeled random (ran) copolymers consisting of N-(2-hydroxypropyl)methacrylamide (HPMA) and lauryl methacrylate (LMA) - including prolonged plasma half-life as well as enhanced tumor accumulation - the presented work focuses on their long-term investigation in the living organism...
December 16, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29406183/efficacy-of-a-new-dual-channel-laryngeal-mask-airway-the-lma-%C3%A2-gastro%C3%A2-airway-for-upper-gastrointestinal-endoscopy-a-prospective-observational-study
#9
N C S Terblanche, C Middleton, D L Choi-Lundberg, M Skinner
BACKGROUND: Significant cardiorespiratory events are frequent in patients undergoing gastrointestinal endoscopy. Central to the occurrence of respiratory events is an unsecured airway. This study sought to determine the efficacy of a new laryngeal mask airway, the LMA ® Gastro TM Airway (Teleflex Medical, Athlone, Ireland), in patients undergoing upper gastrointestinal endoscopy. New design features include a dedicated channel for oesophageal intubation and separate channel with terminal cuff for lung ventilation...
February 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29404890/comparison-of-clinical-performance-of-size-1-5-supreme%C3%A2-lma-and-proseal%C3%A2-lma-among-asian-children-a-randomized-controlled-trial
#10
Sook Hui Chaw, Ina I Shariffuddin, Li Lian Foo, Pui Kuan Lee, Ramona Maya Paran, Peak Chee Cheang, Lucy Chan
To date, most of the studies on safety and efficacy of supraglottic airway devices were done in Caucasian patients, and the results may not be extrapolated to Asian patients due to the different airway anatomy. We conducted this study to compare Supreme™ LMA (SLMA) and Proseal™ LMA (PLMA) size 1.5 in anaesthetized children among an Asian population. This prospective randomized clinical trial was conducted in a tertiary teaching hospital from September 2013 until May 2016. Sixty children, weighing 5-10 kg, who were scheduled for elective surgery under general anaesthesia were recruited and completed the study...
February 5, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29402361/-meta-analysis-of-the-effects-between-endotracheal-intubation-and-laryngeal-mask-airway-for-patients-with-out-of-hospital-cardiac-arrest
#11
Xiangjun Tao, Wei Gu, Xiaojuan Liu, Kaisheng Dong, Ying Wang, Shu Ding
OBJECTIVE: To comprehensively evaluate the resuscitation effect of endotracheal intubation (ETI) ventilation and laryngeal mask airway (LMA) for out-of-hospital cardiac arrest (OHCA). METHODS: Databases such as Cochrane Library, PubMed, Embase, Ebsco, Elsevier, OVID, Springer, Proquest, and China biomedical literature database (CBMdisc), CNKI, Wanfang database, Chinese Science and Technology Journal Full-text Database, VIP Chinese biomedical journal database were searched from the establishment of literature database to December 2017 to study the difference of effects between ETI and LMA for patients with OHCA...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29390007/fagaceae-tree-species-allocate-higher-fraction-of-nitrogen-to-photosynthetic-apparatus-than-leguminosae-in-jianfengling-tropical-montane-rain-forest-china
#12
Jingchao Tang, Ruimei Cheng, Zuomin Shi, Gexi Xu, Shirong Liu, Mauro Centritto
Variation in photosynthetic-nitrogen use efficiency (PNUE) is generally affected by several factors such as leaf nitrogen allocation and leaf diffusional conductances to CO2, although it is still unclear which factors significantly affect PNUE in tropical montane rain forest trees. In this study, comparison of PNUE, photosynthetic capacity, leaf nitrogen allocation, and diffusional conductances to CO2 between five Fagaceae tree species and five Leguminosae tree species were analyzed in Jianfengling tropical montane rain forest, Hainan Island, China...
2018: PloS One
https://www.readbyqxmd.com/read/29375896/ultrasound-comparison-of-external-and-internal-neck-anatomy-with-the-lma-unique
#13
Steven M Lee, Jacek A Wojtczak, Davide Cattano
Introduction: Internal neck anatomy landmarks and their relation after placement of an extraglottic airway devices have not been studied extensively by the use of ultrasound. Based on our group experience with external landmarks as well as internal landmarks evaluation with other techniques, we aimed use ultrasound to analyze the internal neck anatomy landmarks and the related changes due to the placement of the Laryngeal Mask Airway Unique. Methods: Observational pilot investigation...
December 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29359641/representation-of-numerical-magnitude-in-math-anxious-individuals
#14
Àngels Colomé
Larger distance effects in high math-anxious individuals (HMA) performing comparison tasks have previously been interpreted as indicating less precise magnitude representation in this population. A recent study by Dietrich, Huber, Moeller, and Klein limited the effects of math anxiety to symbolic comparison, in which they found larger distance effects for HMA, despite equivalent size effects. However, the question of whether distance effects in symbolic comparison reflect the properties of the magnitude representation or decisional processes is currently under debate...
January 1, 2018: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/29354258/leaf-thermotolerance-in-dry-tropical-forest-tree-species-relationships-with-leaf-traits-and-effects-of-drought
#15
Aniruddh Sastry, Anirban Guha, Deepak Barua
Understanding how tropical trees will respond to extreme temperatures and drought is essential to predict how future increases in the severity, frequency and duration of extreme climatic events will affect tropical systems. In this study, we investigated leaf thermotolerance by quantifying the temperatures that resulted in a 50 % decrease in photosystem II function (T50) in experimentally grown saplings of 12 tree species from a seasonally dry tropical forest. We examined the relationship of thermotolerance with leaf functional traits and photosynthetic rates...
February 2018: AoB Plants
https://www.readbyqxmd.com/read/29329619/hepatic-fibropoiesis-in-dogs-naturally-infected-with-leishmania-leishmania-infantum-treated-with-liposome-encapsulated-meglumine-antimoniate-and-allopurinol
#16
R S Castro, I F G de Amorim, R A Pereira, S M Silva, L J Pinheiro, A J W Pinto, E G Azevedo, C Demicheli, M M V Caliari, D M Mosser, M S M Michalick, Frédéric J G Frezard, Wagner L Tafuri
Hepatic fibropoiesis in canine visceral leishmaniasis (CVL) were evaluated by histological (morphometrical collagen deposition) and immunohistochemical assays characterizing alpha-actin (α-SMA), vimentin, calprotectin (L1 antigen), and TGF-β in 46 naturally infected dogs with Leishmania infantum treated with liposome-encapsulated meglumine antimoniate and allopurinol separately and in combination. Six treatment groups were defined: meglumine antimoniate encapsulated in nanometric liposomes (LMA), allopurinol (ALLOP); liposome-encapsulated meglumine antomoniate combined with allopurinol (LMA+ALLOP); empty liposomes (LEMP); empty liposomes combined with allopurinol (LEMP+ALLOP) and saline...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29329350/incidence-and-risk-factors-for-postoperative-lingual-neuropraxia-following-airway-instrumentation-a-retrospective-matched-case-control-study
#17
Yi-Kai Su, Jen-Hung Wang, Shiu-Ying Hsieh, Xiu-Zhu Liu, Chen-Fuh Lam, Shian-Che Huang
BACKGROUND: Lingual nerve injury or neuropraxia is a rare but potentially serious perioperative complication following airway instrumentation during general anesthesia. This study explored the the incidence and perioperative risk factors for lingual nerve injury in patients receiving laryngeal mask (LMA) or endotracheal (ETGA) general anesthesia in a single center experience. METHODS AND RESULTS: All surgical patients in our hospital who received LMA or ETGA from 2009 to 2013 were included, and potential perioperative risk factors were compared...
2018: PloS One
https://www.readbyqxmd.com/read/29321871/leaf-trait-variations-associated-with-habitat-affinity-of-tropical-karst-tree-species
#18
Nalaka Geekiyanage, Uromi Manage Goodale, Kunfang Cao, Kaoru Kitajima
Karst hills, that is, jagged topography created by dissolution of limestone and other soluble rocks, are distributed extensively in tropical forest regions, including southern parts of China. They are characterized by a sharp mosaic of water and nutrient availability, from exposed hilltops with poor soil development to valleys with occasional flooding, to which trees show species-specific distributions. Here we report the relationship of leaf functional traits to habitat preference of tropical karst trees. We described leaf traits of 19 tropical tree species in a seasonal karst rainforest in Guangxi Province, China, 12 species in situ and 13 ex situ in a non-karst arboretum, which served as a common garden, with six species sampled in both...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29321426/percutaneous-coronary-intervention-for-a-patient-with-left-main-coronary-compression-syndrome
#19
Ryutaro Ikegami, Kazuyuki Ozaki, Takuaya Ozawa, Satoru Hirono, Masahiro Ito, Tohru Minamino
Left main coronary compression syndrome rarely occurs in patients with severe pulmonary hypertension. A 65-year-old woman with severe pulmonary hypertension due to an atrial septal defect suffered from angina on effort. Cardiac computed-tomography and coronary angiography revealed considerable stenosis of the left main coronary artery (LMA) caused by compression between the dilated main pulmonary artery trunk and the sinus of valsalva. Stenting of the LMA under intravascular ultrasound imaging was effective for the treatment of angina...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29315465/ventilation-strategy-and-anesthesia-management-in-patients-with-severe-tracheal-stenosis-undergoing-urgent-tracheal-stenting
#20
J-H Zhu, M Lei, E-G Chen, Q Qiao, T-D Zhong
BACKGROUND: Stenting of airway stenosis is a common procedure in specialized centers. The aim of this study was to summarize our clinical experience in ventilation strategy and anesthesia management of patients undergoing urgent tracheal stenting. METHODS: Clinical data of 22 patients with severe tracheal stenosis who underwent urgent endoscopic placement of a tracheal stent during a 2-year period were retrospectively reviewed. The efficacy and safety of different ventilation strategies and veno-arterial extracorporeal membrane oxygenation (ECMO), individualized based on the cause and location of tracheal narrowing, were evaluated...
January 7, 2018: Acta Anaesthesiologica Scandinavica
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