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bronchiectasis guidelines

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https://www.readbyqxmd.com/read/29587336/oral-versus-inhaled-antibiotics-for-bronchiectasis
#1
REVIEW
Sally Spencer, Lambert M Felix, Stephen J Milan, Rebecca Normansell, Pieter C Goeminne, James D Chalmers, Tim Donovan
BACKGROUND: Bronchiectasis is a chronic inflammatory disease characterised by a recurrent cycle of respiratory bacterial infections associated with cough, sputum production and impaired quality of life. Antibiotics are the main therapeutic option for managing bronchiectasis exacerbations. Evidence suggests that inhaled antibiotics may be associated with more effective eradication of infective organisms and a lower risk of developing antibiotic resistance when compared with orally administered antibiotics...
March 27, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29573520/bronchiectasis-in-the-kimberley-region-of-western-australia
#2
Justin Barton, Lydia Scott, Graeme Maguire
OBJECTIVE: To review the work-up and inpatient management of non-cystic fibrosis bronchiectasis exacerbations against best practice guidelines in Kimberley, a remote region of Western Australia, with the ultimate goal of improving treatment in the region. DESIGN: Retrospective cohort study and audit of remote adult bronchiectasis hospital admissions between 2011 and 2016. SETTING: Remote hospital inpatients. PARTICIPANTS: Thirty-two patients and 110 hospital admissions were included...
March 24, 2018: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29489526/bronchiectasis-update
#3
Anne E O'Donnell
PURPOSE OF REVIEW: Bronchiectasis, once thought to be an orphan disease, is being diagnosed with increased frequency in the United States and around the world. The present review aims to provide an update on recent publications on the diagnosis and management of bronchiectasis. RECENT FINDINGS: Two large bronchiectasis patient registries have published initial reports regarding demographics and other patient data in 2017. Updates on the microbiology, microbiome, and inflammation in patients with bronchiectasis are clarifying the complexities of airway infection in this disease...
April 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29478908/bronchiectasis-new-therapies-and-new-perspectives
#4
REVIEW
James D Chalmers, Sanjay H Chotirmall
European Respiratory Society guidelines for the management of adult bronchiectasis highlight the paucity of treatment options available for patients with this disorder. No treatments have been licensed by regulatory agencies worldwide, and most therapies used in clinical practice are based on very little evidence. Development of new treatments is needed urgently. We did a systematic review of scientific literature and clinical trial registries to identify agents in early-to-late clinical development for bronchiectasis in adults...
February 22, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29470253/management-of-nontuberculous-mycobacterial-pulmonary-disease
#5
Mark H Adelman, Doreen J Addrizzo-Harris
PURPOSE OF REVIEW: To highlight recent original research and specialty society guidelines regarding the diagnosis and treatment of nontuberculous mycobacterial (NTM) pulmonary disease. RECENT FINDINGS: The prevalence of NTM pulmonary disease has risen in recent years. The prevalence of individual NTM species varies geographically, although Mycobacterium avium complex (MAC) and Mycobacterium abscessus complex (MABC) remain among the most commonly encountered in many regions...
May 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29420096/gamma-globulin-replacement-therapy-in-uncontrolled-severe-asthma-associated-with-humoral-immunodeficiency-a-series-of-five-case-reports
#6
Angelica Tiotiu, Yves Martinet, Roger Jankowski, Philippe Devillier
We report on five adult cases of the rare association of asthma with humoral immunodeficiency (huID). All patients had uncontrolled asthma related to recurrent respiratory infections. Asthma was diagnosed according to the Global Initiative for Asthma (GINA) guidelines, and bronchiectasis was ruled out by a CT chest scan. Two men (aged 28 and 60) presented with pollen allergies, chronic rhinosinusitis, and IgG deficiency (7.8 and 7.6 g/L, respectively). Both patients underwent surgery for nasal polyposis but relapsed with acute sinusitis and severe asthma exacerbations requiring treatment with oral corticosteroids and antibiotics...
February 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29411860/self-management-for-bronchiectasis
#7
REVIEW
Carol Kelly, Seamus Grundy, Dave Lynes, David Jw Evans, Sharada Gudur, Stephen J Milan, Sally Spencer
BACKGROUND: Bronchiectasis is a long term respiratory condition with an increasing rate of diagnosis. It is associated with persistent symptoms, repeated infective exacerbations, and reduced quality of life, imposing a burden on individuals and healthcare systems. The main aims of therapeutic management are to reduce exacerbations and improve quality of life. Self-management interventions are potentially important for empowering people with bronchiectasis to manage their condition more effectively and to seek care in a timely manner...
February 7, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29355548/treating-cough-due-to-non-cf-and-cf-bronchiectasis-with-nonpharmacological-airway-clearance-chest-expert-panel-report
#8
Adam T Hill, Alan F Barker, Donald C Bolser, Paul Davenport, Belinda Ireland, Anne B Chang, Stuart B Mazzone, Lorcan McGarvey
BACKGROUND: In bronchiectasis due to cystic fibrosis (CF) and other causes, airway clearance is one of the mainstays of management. We conducted a systematic review on airway clearance by using non-pharmacological methods as recommended by international guidelines to develop recommendations or suggestions to update the 2006 CHEST guideline on cough. METHODS: The systematic search for evidence examined the question, "Is there evidence of clinically important treatment effects for non-pharmacological therapies in cough treatment for patients with bronchiectasis?" Populations selected were all patients with bronchiectasis due to CF or non-CF bronchiectasis...
April 2018: Chest
https://www.readbyqxmd.com/read/29284507/a-pediatric-disease-to-keep-in-mind-diagnostic-tools-and-management-of-bronchiectasis-in-pediatric-age
#9
REVIEW
Marcella Gallucci, Emanuela di Palmo, Luca Bertelli, Federica Camela, Giampaolo Ricci, Andrea Pession
Bronchiectasis in pediatric age is a heterogeneous disease associated with significant morbidity.The most common medical conditions leading to bronchial damage are previous pneumonia and recurrent lower airway infections followed by underlying diseases such as immune-deficiencies, congenital airway defects, recurrent aspirations and mucociliary clearance disorders.The most frequent symptom is chronic wet cough. The introduction of high-resolution computed tomography (HRCT) has improved the time of diagnosis allowing earlier treatment...
December 29, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29225784/diagnosing-alpha-1-antitrypsin-deficiency-the-first-step-in-precision-medicine
#10
REVIEW
Craig P Hersh
Severe alpha-1 antitrypsin (AAT) deficiency is one of the most common serious genetic diseases in adults of European descent. Individuals with AAT deficiency have a greatly increased risk for emphysema and liver disease. Other manifestations include bronchiectasis, necrotizing panniculitis and granulomatosis with polyangiitis. Despite the frequency and potential severity, AAT deficiency remains under-recognized, and there is often a delay in diagnosis. This review will focus on three recent updates that should serve to encourage testing and diagnosis of AAT deficiency: first, the publication of a randomized clinical trial demonstrating the efficacy of intravenous augmentation therapy in slowing the progression of emphysema in AAT deficiency; second, the mounting evidence showing an increased risk of lung disease in heterozygous PI MZ genotype carriers; last, the recent publication of a clinical practice guideline, outlining diagnosis and management...
2017: F1000Research
https://www.readbyqxmd.com/read/29128130/spanish-guidelines-on-the-evaluation-and-diagnosis-of-bronchiectasis-in-adults
#11
Miguel Ángel Martínez-García, Luis Máiz, Casilda Olveira, Rosa María Girón, David de la Rosa, Marina Blanco, Rafael Cantón, Montserrat Vendrell, Eva Polverino, Javier de Gracia, Concepción Prados
In 2008, the Spanish Society of Pulmonology (SEPAR) published the first guidelines in the world on the diagnosis and treatment of bronchiectasis. Almost 10 years later, considerable scientific advances have been made in both the treatment and the evaluation and diagnosis of this disease, and the original guidelines have been updated to include the latest scientific knowledge on bronchiectasis. These new recommendations have been drafted following a strict methodological process designed to ensure the quality of content, and are linked to a large amount of online information that includes a wealth of references...
February 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29128129/spanish-guidelines-on-treatment-of-bronchiectasis-in-adults
#12
Miguel Ángel Martínez-García, Luis Máiz, Casilda Olveira, Rosa Maria Girón, David de la Rosa, Marina Blanco, Rafael Cantón, Montserrat Vendrell, Eva Polverino, Javier de Gracia, Concepción Prados
In 2008, the Spanish Society of Pulmonology (SEPAR) published the first guidelines in the world on the diagnosis and treatment of bronchiectasis. Almost 10 years later, considerable scientific advances have been made in both the treatment and the evaluation and diagnosis of this disease, and the original guidelines have been updated to include the latest therapies available for bronchiectasis. These new recommendations have been drafted following a strict methodological process designed to ensure quality of content, and are linked to a large amount of online information that includes a wealth of references...
February 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29099029/the-bronchiectasis-toolbox-a-comprehensive-website-for-the-management-of-people-with-bronchiectasis
#13
Caroline H Nicolson, Anne E Holland, Annemarie L Lee
While the health burden of bronchiectasis is increasing worldwide, medical and physiotherapy treatment strategies have progressed significantly over the past decade. For this reason, clinicians require readily accessible current evidence based information on the management of this condition. E-learning is a suitable educational forum for the development and maintenance of professional skills, however a comprehensive, evidence based, multidisciplinary website for bronchiectasis was not available. The Bronchiectasis Toolbox at www...
June 12, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29038903/-nontuberculous-mycobacteria-in-sputum-recommendations-for-diagnosis-and-treatment
#14
REVIEW
J Rademacher
Pulmonary diseases caused by nontuberculous mycobacteria (NTM) have increased over the last years and decades in Germany and also worldwide. Because the disease is more frequent in patients with immunodeficiencies and chronic respiratory diseases, e.g. bronchiectasis, advanced chronic obstructive lung disease (COPD) and cystic fibrosis (CF), an infection with mycobacteria should always be considered in this patient group. The detection in sputum alone is not an indication for treatment but the correct diagnosis should be based on the appropriate clinical symptoms as well as radiological and microbiological criteria...
November 2017: Der Internist
https://www.readbyqxmd.com/read/28967797/pulmonary-disease-by-non-tuberculous-mycobacteria-clinical-management-unmet-needs-and-future-perspectives
#15
Lars-Olof Larsson, Eva Polverino, Wouter Hoefsloot, Luigi R Codecasa, Roland Diel, Stephen G Jenkins, Michael R Loebinger
The number of patients with pulmonary disease caused by non-tuberculous mycobacteria (NTM) is increasing globally. Poor resistance against infections, for example, due to pre-existing lung diseases, immune deficiency and immune-modulating treatment, predisposes the population to developing pulmonary NTM disease. The incidence of pre-existing lung diseases such as chronic obstructive pulmonary disease and bronchiectasis has also increased. NTM disease diagnosis is often delayed due to non-specific symptoms. The therapeutic arsenal is limited and adherence to treatment guidelines is often low since the treatment regimens are complex, lengthy and side effects are common...
December 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28947036/possible-uip-pattern-on-high-resolution-computed-tomography-is-associated-with-better-survival-than-definite-uip-in-ipf-patients
#16
Margaret L Salisbury, Leslie B Tolle, Meng Xia, Susan Murray, Nabihah Tayob, Anoop M Nambiar, Shelley L Schmidt, Amir Lagstein, Jeffery L Myers, Barry H Gross, Ella A Kazerooni, Baskaran Sundaram, Aamer R Chughtai, Fernando J Martinez, Kevin R Flaherty
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing lung disease of unknown etiology. Inter-society consensus guidelines on IPF diagnosis and management outline radiologic patterns including definite usual interstitial pneumonia (UIP), possible UIP, and inconsistent with UIP. We evaluate these diagnostic categories as prognostic markers among patients with IPF. METHODS: Included subjects had biopsy-proven UIP, a multidisciplinary team diagnosis of IPF, and a baseline high-resolution computed tomography (HRCT)...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28894480/patient-participation-in-ers-guidelines-and-research-projects-the-embarc-experience
#17
REVIEW
James D Chalmers, Alan Timothy, Eva Polverino, Marta Almagro, Thomas Ruddy, Pippa Powell, Jeanette Boyd
The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) is a European Respiratory Society (ERS) Clinical Research Collaboration dedicated to improving research and clinical care for people with bronchiectasis. EMBARC has created a European Bronchiectasis Registry, funded by the ERS and by the European Union (EU) Innovative Medicines Initiative Programme. From the outset, EMBARC had the ambition to be a patient-focussed project. In contrast to many respiratory diseases, however, there are no specific patient charities or European patient organisations for patients with bronchiectasis and no existing infrastructure for patient engagement...
September 2017: Breathe
https://www.readbyqxmd.com/read/28894479/the-european-multicentre-bronchiectasis-audit-and-research-collaboration-embarc-experiences-from-a-successful-ers-clinical-research-collaboration
#18
REVIEW
James D Chalmers, Megan Crichton, Pieter C Goeminne, Michael R Loebinger, Charles Haworth, Marta Almagro, Montse Vendrell, Anthony De Soyza, Raja Dhar, Lucy Morgan, Francesco Blasi, Stefano Aliberti, Jeanette Boyd, Eva Polverino
In contrast to airway diseases like chronic obstructive pulmonary disease or asthma, and rare diseases such as cystic fibrosis, there has been little research and few clinical trials in bronchiectasis. Guidelines are primarily based on expert opinion and treatment is challenging because of the heterogeneous nature of the disease. In an effort to address decades of underinvestment in bronchiectasis research, education and clinical care, the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) was established in 2012 as a collaborative pan-European network to bring together bronchiectasis researchers...
September 2017: Breathe
https://www.readbyqxmd.com/read/28889110/european-respiratory-society-guidelines-for-the-management-of-adult-bronchiectasis
#19
Eva Polverino, Pieter C Goeminne, Melissa J McDonnell, Stefano Aliberti, Sara E Marshall, Michael R Loebinger, Marlene Murris, Rafael Cantón, Antoni Torres, Katerina Dimakou, Anthony De Soyza, Adam T Hill, Charles S Haworth, Montserrat Vendrell, Felix C Ringshausen, Dragan Subotic, Robert Wilson, Jordi Vilaró, Bjorn Stallberg, Tobias Welte, Gernot Rohde, Francesco Blasi, Stuart Elborn, Marta Almagro, Alan Timothy, Thomas Ruddy, Thomy Tonia, David Rigau, James D Chalmers
Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent exacerbations in many patients. There have been no previous international guidelines.The European Respiratory Society guidelines for the management of adult bronchiectasis describe the appropriate investigation and treatment strategies determined by a systematic review of the literature.A multidisciplinary group representing respiratory medicine, microbiology, physiotherapy, thoracic surgery, primary care, methodology and patients considered the most relevant clinical questions (for both clinicians and patients) related to management of bronchiectasis...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28869119/does-home-based-pulmonary-rehabilitation-improve-functional-capacity-peripheral-muscle-strength-and-quality-of-life-in-patients-with-bronchiectasis-compared-to-standard-care
#20
Anderson José, Anne E Holland, Cristiane S de Oliveira, Jessyca P R Selman, Rejane A S de Castro, Rodrigo A Athanazio, Samia Z Rached, Alberto Cukier, Rafael Stelmach, Simone Dal Corso
BACKGROUND: Home-based pulmonary rehabilitation is a promising intervention that may help patients to overcome the barriers to undergoing pulmonary rehabilitation. However, home-based pulmonary rehabilitation has not yet been investigated in patients with bronchiectasis. OBJECTIVES: To investigate the effects of home-based pulmonary rehabilitation in patients with bronchiectasis. METHODS: An open-label, randomized controlled trial with 48 adult patients with bronchiectasis will be conducted...
November 2017: Brazilian Journal of Physical Therapy
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