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https://www.readbyqxmd.com/read/29909286/immersive-3d-exposure-based-treatment-for-spider-fear-a-randomized-controlled-trial
#1
Sean Minns, Andrew Levihn-Coon, Emily Carl, Jasper A J Smits, Wayne Miller, Don Howard, Santiago Papini, Simon Quiroz, Eunjung Lee-Furman, Michael Telch, Per Carlbring, Drew Xanthopoulos, Mark B Powers
Stereoscopic 3D gives the viewer the same shape, size, perspective and depth they would experience viewing the real world and could mimic the perceptual threat cues present in real life. This is the first study to investigate whether an immersive stereoscopic 3D video exposure-based treatment would be effective in reducing fear of spiders. Participants with a fear of spiders (N = 77) watched two psychoeducational videos with facts about spiders and phobias. They were then randomized to a treatment condition that watched a single session of a stereoscopic 3D immersive video exposure-based treatment (six 5-min exposures) delivered through a virtual reality headset or a psychoeducation only control condition that watched a 30-min neutral video (2D documentary) presented on a computer monitor...
June 4, 2018: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29907866/intestinal-damage-precedes-mucosal-immune-dysfunction-in-siv-infection
#2
Tiffany Hensley-McBain, Alicia R Berard, Jennifer A Manuzak, Charlene J Miller, Alexander S Zevin, Patricia Polacino, Jillian Gile, Brian Agricola, Mark Cameron, Shiu-Lok Hu, Jacob D Estes, R Keith Reeves, Jeremy Smedley, Brandon F Keele, Adam D Burgener, Nichole R Klatt
HIV and pathogenic SIV infection are characterized by mucosal dysfunction including epithelial barrier damage, loss of Th17 cells, neutrophil infiltration, and microbial translocation with accompanying inflammation. However, it is unclear how and when these contributing factors occur relative to one another. In order to determine whether any of these features initiates the cycle of damage, we longitudinally evaluated the kinetics of mucosal and systemic T-cell activation, microbial translocation, and Th17 cell and neutrophil frequencies following intrarectal SIV infection of rhesus macaques...
June 15, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29907552/beyond-maximum-grade-modernising-the-assessment-and-reporting-of-adverse-events-in-haematological-malignancies
#3
REVIEW
Gita Thanarajasingam, Lori M Minasian, Frederic Baron, Franco Cavalli, R Angelo De Claro, Amylou C Dueck, Tarec C El-Galaly, Neil Everest, Jan Geissler, Christian Gisselbrecht, John Gribben, Mary Horowitz, S Percy Ivy, Caron A Jacobson, Armand Keating, Paul G Kluetz, Aviva Krauss, Yok Lam Kwong, Richard F Little, Francois-Xavier Mahon, Matthew J Matasar, María-Victoria Mateos, Kristen McCullough, Robert S Miller, Mohamad Mohty, Philippe Moreau, Lindsay M Morton, Sumimasa Nagai, Simon Rule, Jeff Sloan, Pieter Sonneveld, Carrie A Thompson, Kyriaki Tzogani, Flora E van Leeuwen, Galina Velikova, Diego Villa, John R Wingard, Sophie Wintrich, John F Seymour, Thomas M Habermann
Tremendous progress in treatment and outcomes has been achieved across the whole range of haematological malignancies in the past two decades. Although cure rates for aggressive malignancies have increased, nowhere has progress been more impactful than in the management of typically incurable forms of haematological cancer. Population-based data have shown that 5-year survival for patients with chronic myelogenous and chronic lymphocytic leukaemia, indolent B-cell lymphomas, and multiple myeloma has improved markedly...
June 12, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29904612/proteomic-identification-of-potential-markers-of-myosteatosis-in-human-urine
#4
Holger Husi, Alisdair MacDonald, Richard J E Skipworth, Janice Miller, Andrew Cronshaw, Kenneth C H Fearon, James A Ross
Myosteatosis, the infiltration of fat in skeletal muscle, is associated with lower skeletal muscle density (SMD) as detected by computed tomography (CT). It increases with aging and obesity and is thought to play a role in the aetiology of insulin resistance and type II diabetes. The clinical significance of myosteatosis in cancer cachexia, however, remains to be determined. Along with demonstrable subcutaneous and visceral lipolysis, myosteatosis may also be a key component of the syndrome. We aimed to investigate the use of human urine as a non-invasive way to screen for molecular biomarkers of myosteatosis/reduced SMD using SELDI-TOF mass spectrometry...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29899868/distinct-age-associated-molecular-profiles-in-acute-myeloid-leukemia-defined-by-comprehensive-clinical-genomic-profiling
#5
Katherine Tarlock, Shan Zhong, Yuting He, Rhonda Ries, Eric Severson, Mark Bailey, Samantha Morley, Sohail Balasubramanian, Rachel Erlich, Doron Lipson, Geoff A Otto, Jo-Anne Vergillo, E Anders Kolb, Jeffrey S Ross, Tariq Mughal, Philip J Stephens, Vincent Miller, Soheil Meshinchi, Jie He
Large scale comprehensive genomic profiling (CGP) has led to an improved understanding of oncogenic mutations in acute myeloid leukemia (AML), as well as identification of alterations that can serve as targets for potential therapeutic intervention. We sought to gain insight into age-associated variants in AML through comparison of extensive DNA and RNA-based GP results from pediatric and adult AML. Sequencing of 932 AML specimens (179 pediatric (age 0-18), 753 adult (age ≥ 19)) from diagnostic, relapsed, and refractory times points was performed...
May 29, 2018: Oncotarget
https://www.readbyqxmd.com/read/29897034/posttraumatic-psychopathology-and-the-pace-of-the-epigenetic-clock-a-longitudinal-investigation
#6
Erika J Wolf, Mark W Logue, Filomene G Morrison, Elizabeth S Wilcox, Annjanette Stone, Steven A Schichman, Regina E McGlinchey, William P Milberg, Mark W Miller
BACKGROUND: Posttraumatic stress disorder (PTSD) and stress/trauma exposure are cross-sectionally associated with advanced DNA methylation age relative to chronological age. However, longitudinal inquiry and examination of associations between advanced DNA methylation age and a broader range of psychiatric disorders is lacking. The aim of this study was to examine if PTSD, depression, generalized anxiety, and alcohol-use disorders predicted acceleration of DNA methylation age over time (i...
June 13, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29884620/interaction-of-localized-drivers-and-disorganized-activation-in-persistent-atrial-fibrillation-reconciling-putative-mechanisms-using-multiple-mapping-techniques
#7
Christopher A B Kowalewski, Fatemah Shenasa, Miguel Rodrigo, Paul Clopton, Gabriela Meckler, Mahmood I Alhusseini, Mark A Swerdlow, Vijay Joshi, Samir Hossainy, Junaid A B Zaman, Tina Baykaner, Albert J Rogers, Johannes Brachmann, John M Miller, David E Krummen, William H Sauer, Nicholas S Peters, Paul J Wang, Sanjiv M Narayan
BACKGROUND: Mechanisms for persistent atrial fibrillation (AF) are unclear. We hypothesized that putative AF drivers and disorganized zones may interact dynamically over short time scales. We studied this interaction over prolonged durations, focusing on regions where ablation terminates persistent AF using 2 mapping methods. METHODS: We recruited 55 patients with persistent AF in whom ablation terminated AF prior to pulmonary vein isolation from a multicenter registry...
June 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29882693/physiologic-preoperative-knee-hyperextension-is-a-predictor-of-failure-in-an-anterior-cruciate-ligament-revision-cohort-a-report-from-the-mars-group
#8
Daniel E Cooper, Warren R Dunn, Laura J Huston, Amanda K Haas, Kurt P Spindler, Christina R Allen, Allen F Anderson, Thomas M DeBerardino, Brett Brick A Lantz, Barton Mann, Michael J Stuart, John P Albright, Annunziato Ned Amendola, Jack T Andrish, Christopher C Annunziata, Robert A Arciero, Bernard R Bach, Champ L Baker, Arthur R Bartolozzi, Keith M Baumgarten, Jeffery R Bechler, Jeffrey H Berg, Geoffrey A Bernas, Stephen F Brockmeier, Robert H Brophy, Charles A Bush-Joseph, J Brad Butler V, John D Campbell, James L Carey, James E Carpenter, Brian J Cole, Jonathan M Cooper, Charles L Cox, R Alexander Creighton, Diane L Dahm, Tal S David, David C Flanigan, Robert W Frederick, Theodore J Ganley, Elizabeth A Garofoli, Charles J Gatt, Steven R Gecha, James Robert Giffin, Sharon L Hame, Jo A Hannafin, Christopher D Harner, Norman Lindsay Harris, Keith S Hechtman, Elliott B Hershman, Rudolf G Hoellrich, Timothy M Hosea, David C Johnson, Timothy S Johnson, Morgan H Jones, Christopher C Kaeding, Ganesh V Kamath, Thomas E Klootwyk, Bruce A Levy, C Benjamin Ma, G Peter Maiers, Robert G Marx, Matthew J Matava, Gregory M Mathien, David R McAllister, Eric C McCarty, Robert G McCormack, Bruce S Miller, Carl W Nissen, Daniel F O'Neill, Brett D Owens, Richard D Parker, Mark L Purnell, Arun J Ramappa, Michael A Rauh, Arthur C Rettig, Jon K Sekiya, Kevin G Shea, Orrin H Sherman, James R Slauterbeck, Matthew V Smith, Jeffrey T Spang, Steven J Svoboda, Timothy N Taft, Joachim J Tenuta, Edwin M Tingstad, Armando F Vidal, Darius G Viskontas, Richard A White, James S Williams, Michelle L Wolcott, Brian R Wolf, James J York, Rick W Wright
BACKGROUND: The occurrence of physiologic knee hyperextension (HE) in the revision anterior cruciate ligament reconstruction (ACLR) population and its effect on outcomes have yet to be reported. Hypothesis/Purpose: The prevalence of knee HE in revision ACLR and its effect on 2-year outcome were studied with the hypothesis that preoperative physiologic knee HE ≥5° is a risk factor for anterior cruciate ligament (ACL) graft rupture. STUDY DESIGN: Cohort study; Level of evidence, 2...
June 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29872430/high-speed-single-molecule-tracking-of-cxcl13-in-the-b-follicle
#9
Helen Miller, Jason Cosgrove, Adam J M Wollman, Emily Taylor, Zhaokun Zhou, Peter J O'Toole, Mark C Coles, Mark C Leake
Soluble factors are an essential means of communication between cells and their environment. However, many molecules readily interact with extracellular matrix components, giving rise to multiple modes of diffusion. The molecular quantification of diffusion in situ is thus a challenging imaging frontier, requiring very high spatial and temporal resolution. Overcoming this methodological barrier is key to understanding the precise spatial patterning of the extracellular factors that regulate immune function...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29860482/global-regional-and-national-cancer-incidence-mortality-years-of-life-lost-years-lived-with-disability-and-disability-adjusted-life-years-for-29-cancer-groups-1990-to-2016-a-systematic-analysis-for-the-global-burden-of-disease-study
#10
Christina Fitzmaurice, Tomi F Akinyemiju, Faris Hasan Al Lami, Tahiya Alam, Reza Alizadeh-Navaei, Christine Allen, Ubai Alsharif, Nelson Alvis-Guzman, Erfan Amini, Benjamin O Anderson, Olatunde Aremu, Al Artaman, Solomon Weldegebreal Asgedom, Reza Assadi, Tesfay Mehari Atey, Leticia Avila-Burgos, Ashish Awasthi, Huda Omer Ba Saleem, Aleksandra Barac, James R Bennett, Isabela M Bensenor, Nickhill Bhakta, Hermann Brenner, Lucero Cahuana-Hurtado, Carlos A Castañeda-Orjuela, Ferrán Catalá-López, Jee-Young Jasmine Choi, Devasahayam Jesudas Christopher, Sheng-Chia Chung, Maria Paula Curado, Lalit Dandona, Rakhi Dandona, José das Neves, Subhojit Dey, Samath D Dharmaratne, David Teye Doku, Tim R Driscoll, Manisha Dubey, Hedyeh Ebrahimi, Dumessa Edessa, Ziad El-Khatib, Aman Yesuf Endries, Florian Fischer, Lisa M Force, Kyle J Foreman, Solomon Weldemariam Gebrehiwot, Sameer Vali Gopalani, Giuseppe Grosso, Rahul Gupta, Bishal Gyawali, Randah Ribhi Hamadeh, Samer Hamidi, James Harvey, Hamid Yimam Hassen, Roderick J Hay, Simon I Hay, Behzad Heibati, Molla Kahssay Hiluf, Nobuyuki Horita, H Dean Hosgood, Olayinka S Ilesanmi, Kaire Innos, Farhad Islami, Mihajlo B Jakovljevic, Sarah Charlotte Johnson, Jost B Jonas, Amir Kasaeian, Tesfaye Dessale Kassa, Yousef Saleh Khader, Ejaz Ahmad Khan, Gulfaraz Khan, Young-Ho Khang, Mohammad Hossein Khosravi, Jagdish Khubchandani, Jacek A Kopec, G Anil Kumar, Michael Kutz, Deepesh Pravinkumar Lad, Alessandra Lafranconi, Qing Lan, Yirga Legesse, James Leigh, Shai Linn, Raimundas Lunevicius, Azeem Majeed, Reza Malekzadeh, Deborah Carvalho Malta, Lorenzo G Mantovani, Brian J McMahon, Toni Meier, Yohannes Adama Melaku, Mulugeta Melku, Peter Memiah, Walter Mendoza, Tuomo J Meretoja, Haftay Berhane Mezgebe, Ted R Miller, Shafiu Mohammed, Ali H Mokdad, Mahmood Moosazadeh, Paula Moraga, Seyyed Meysam Mousavi, Vinay Nangia, Cuong Tat Nguyen, Vuong Minh Nong, Felix Akpojene Ogbo, Andrew Toyin Olagunju, Mahesh Pa, Eun-Kee Park, Tejas Patel, David M Pereira, Farhad Pishgar, Maarten J Postma, Farshad Pourmalek, Mostafa Qorbani, Anwar Rafay, Salman Rawaf, David Laith Rawaf, Gholamreza Roshandel, Saeid Safiri, Hamideh Salimzadeh, Juan Ramon Sanabria, Milena M Santric Milicevic, Benn Sartorius, Maheswar Satpathy, Sadaf G Sepanlou, Katya Anne Shackelford, Masood Ali Shaikh, Mahdi Sharif-Alhoseini, Jun She, Min-Jeong Shin, Ivy Shiue, Mark G Shrime, Abiy Hiruye Sinke, Mekonnen Sisay, Amber Sligar, Muawiyyah Babale Sufiyan, Bryan L Sykes, Rafael Tabarés-Seisdedos, Gizachew Assefa Tessema, Roman Topor-Madry, Tung Thanh Tran, Bach Xuan Tran, Kingsley Nnanna Ukwaja, Vasiliy Victorovich Vlassov, Stein Emil Vollset, Elisabete Weiderpass, Hywel C Williams, Nigus Bililign Yimer, Naohiro Yonemoto, Mustafa Z Younis, Christopher J L Murray, Mohsen Naghavi
Importance: The increasing burden due to cancer and other noncommunicable diseases poses a threat to human development, which has resulted in global political commitments reflected in the Sustainable Development Goals as well as the World Health Organization (WHO) Global Action Plan on Non-Communicable Diseases. To determine if these commitments have resulted in improved cancer control, quantitative assessments of the cancer burden are required. Objective: To assess the burden for 29 cancer groups over time to provide a framework for policy discussion, resource allocation, and research focus...
June 2, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29860363/enhanced-invitations-using-the-question-behavior-effect-and-financial-incentives-to-promote-health-check-uptake-in-primary-care
#11
Lisa McDermott, Victoria Cornelius, Alison J Wright, Caroline Burgess, Alice S Forster, Mark Ashworth, Bernadette Khoshaba, Philippa Clery, Frances Fuller, Jane Miller, Hiten Dodhia, Caroline Rudisill, Mark T Conner, Martin C Gulliford
Background: Uptake of health checks for cardiovascular risk assessment in primary care in England is lower than anticipated. The question-behavior effect (QBE) may offer a simple, scalable intervention to increase health check uptake. Purpose: The present study aimed to evaluate the effectiveness of enhanced invitation methods employing the QBE, with or without a financial incentive to return the questionnaire, at increasing uptake of health checks. Methods: We conducted a three-arm randomized trial including all patients at 18 general practices in two London boroughs, who were invited for health checks from July 2013 to December 2014...
May 31, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29846010/bioaccumulation-and-effects-of-dietary-exposure-to-the-alternative-flame-retardant-bis-2-ethylhexyl-tetrabromophthalate-tbph-in-the-atlantic-killifish-fundulus-heteroclitus
#12
Diane Nacci, Bryan Clark, Mark J La Guardia, Ken Miller, Denise Champlin, Ian Kirby, Ashley Bertrand, Saro Jayaraman
Bis(2-ethylhexyl) tetrabromophthalate (TBPH), a high production volume flame retardant (FR) chemical used as a replacement for banned FRs, has been detected in media and human and wildlife tissues globally. Here we describe bioaccumulation and biological effects from dietary exposure of TBPH to an estuarine fish, Atlantic killifish, Fundulus heteroclitus. Briefly, adult fish were fed carrier control- or chemically-amended diets for 28 d, followed by 14 d control diet feeding. Diets were amended with TBPH (TBPH_LO diet, 139 µg/g dry weight, dw, or TBPH_HI diet, 4360 µg/g dw) or a polychlorinated biphenyl congener (PCB153 diet, 13 µg/g dw), which was included as a positive control for bioaccumulation...
May 30, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29799360/the-state-of-aging-policy-and-politics-in-the-trump-era
#13
Edward Alan Miller, Pamela Nadash, Michael K Gusmano, Elizabeth Simpson, Corina R Ronneberg
The surprise election of Donald J. Trump to the presidency of the United States marks a singular turning point in the American republic - not only because of his idiosyncratic approach to the office, but also because the Republican Party now holds the Presidency and both houses of Congress, presenting an historic opportunity for change. The role of older Americans has been critical in both shaping and reacting to this political moment. Their political orientations and behaviors have shaped it through their electoral support for Republican candidates, but they also stand as highly invested stakeholders in the policy decisions made by the very officials they elected, and as beneficiaries of the programs that Republicans have targeted...
May 25, 2018: Journal of Aging & Social Policy
https://www.readbyqxmd.com/read/29785013/genetic-identification-of-brain-cell-types-underlying-schizophrenia
#14
Nathan G Skene, Julien Bryois, Trygve E Bakken, Gerome Breen, James J Crowley, Héléna A Gaspar, Paola Giusti-Rodriguez, Rebecca D Hodge, Jeremy A Miller, Ana B Muñoz-Manchado, Michael C O'Donovan, Michael J Owen, Antonio F Pardiñas, Jesper Ryge, James T R Walters, Sten Linnarsson, Ed S Lein, Patrick F Sullivan, Jens Hjerling-Leffler
With few exceptions, the marked advances in knowledge about the genetic basis of schizophrenia have not converged on findings that can be confidently used for precise experimental modeling. By applying knowledge of the cellular taxonomy of the brain from single-cell RNA sequencing, we evaluated whether the genomic loci implicated in schizophrenia map onto specific brain cell types. We found that the common-variant genomic results consistently mapped to pyramidal cells, medium spiny neurons (MSNs) and certain interneurons, but far less consistently to embryonic, progenitor or glial cells...
May 21, 2018: Nature Genetics
https://www.readbyqxmd.com/read/29773717/stk11-lkb1-mutations-and-pd-1-inhibitor-resistance-in-kras-mutant-lung-adenocarcinoma
#15
Ferdinandos Skoulidis, Michael E Goldberg, Danielle M Greenawalt, Matthew D Hellmann, Mark M Awad, Justin F Gainor, Alexa B Schrock, Ryan J Hartmaier, Sally E Trabucco, Laurie Gay, Siraj M Ali, Julia A Elvin, Gaurav Singal, Jeffrey S Ross, David Fabrizio, Peter M Szabo, Han Chang, Ariella Sasson, Sujaya Srinivasan, Stefan Kirov, Joseph Szustakowski, Patrik Vitazka, Robin Edwards, Jose A Bufill, Neelesh Sharma, Sai-Hong I Ou, Nir Peled, David R Spigel, Hira Rizvi, Elizabeth Jimenez Aguilar, Brett W Carter, Jeremy Erasmus, Darragh F Halpenny, Andrew J Plodkowski, Niamh M Long, Mizuki Nishino, Warren L Denning, Ana Galan-Cobo, Haifa Hamdi, Taghreed Hirz, Pan Tong, Jing Wang, Jaime Rodriguez-Canales, Pamela A Villalobos, Edwin R Parra, Neda Kalhor, Lynette M Sholl, Jennifer L Sauter, Achim A Jungbluth, Mari Mino-Kenudson, Roxana Azimi, Yasir Y Elamin, Jianjun Zhang, Giulia C Leonardi, Fei Jiang, Kwok-Kin Wong, J Jack Lee, Vassiliki A Papadimitrakopoulou, Ignacio I Wistuba, Vincent A Miller, Garrett M Frampton, Jedd D Wolchok, Alice T Shaw, Pasi A Jänne, Philip J Stephens, Charles M Rudin, William J Geese, Lee A Albacker, John V Heymach
KRAS is the most common oncogenic driver in lung adenocarcinoma (LUAC). We previously reported that STK11/LKB1 (KL) or TP53 (KP) co-mutations define distinct subgroups of KRAS-mutant LUAC. Here, we examine the efficacy of PD-1 inhibitors in these subgroups. Objective response rates to PD-1 blockade differed significantly among KL (7.4%), KP (35.7%), and K-only (28.6%) subgroups (P<0.001) in the SU2C cohort (174 patients) with KRAS-mutant LUAC and in patients treated with nivolumab in the CheckMate-057 phase 3 trial (0% vs 57...
May 17, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29762340/external-validation-of-the-adult-spinal-deformity-asd-frailty-index-asd-fi-in-the-scoli-risk-1-patient-database
#16
Emily K Miller, Lawrence G Lenke, Brian J Neuman, Daniel M Sciubba, Khaled M Kebaish, Justin S Smith, Yong Qiu, Benny T Dahl, Ferran Pellisé, Yukihiro Matsuyama, Leah Y Carreon, Michael G Fehlings, Kenneth M Cheung, Stephen Lewis, Mark B Dekutoski, Frank J Schwab, Oheneba Boachie-Adjei, Hossein Mehdian, Shay Bess, Christopher I Shaffrey, Christopher P Ames
STUDY DESIGN: Analysis of a prospective multicenter database. OBJECTIVE: To assess the ability of the recently created Adult Spinal Deformity (ASD) Frailty Index (ASD-FI) to predict odds of major complications and length of hospital stay for patients who had more severe preoperative deformity and underwent more invasive ASD surgery compared with patients in the database used to create the index. SUMMARY OF BACKGROUND DATA: Accurate preoperative estimates of risk are necessary given the high complication rates currently associated with ASD surgery...
May 14, 2018: Spine
https://www.readbyqxmd.com/read/29758282/stevens-johnson-syndrome-toxic-epidermal-necrolysis-a-multicenter-retrospective-study-of-377-adult-patients-from-the-united-states
#17
Robert G Micheletti, Zelma Chiesa-Fuxench, Megan H Noe, Sasha Stephen, Maria Aleshin, Ashwin Agarwal, Jennifer Boggs, Adela R Cardones, Jennifer K Chen, Jonathan Cotliar, Mark Dp Davis, Arturo Dominguez, Lindy P Fox, Shayna Gordon, Ronald Hamrick, Baran Ho, Lauren C Hughey, Larry M Jones, Benjamin H Kaffenberger, Kimball Kindley, Daniela Kroshinsky, Bernice Y Kwong, Daniel D Miller, Arash Mostaghimi, Amy Musiek, Alex G Ortega-Loayza, Raj Patel, Alba Posligua, Monica Rani, Sandeep Saluja, Victoria R Sharon, Kanade Shinkai, Jessica St John, Nicole Strickland, Erika M Summers, Natalie Sun, Karolyn A Wanat, David A Wetter, Scott Worswick, Caroline Yang, David J Margolis, Joel M Gelfand, Misha Rosenbach
Stevens-Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) is a rare, severe mucocutaneous reaction with few large cohorts reported. This multicenter retrospective study included patients with SJS/TEN seen by inpatient consultative dermatologists at 18 academic medical centers in the United States. 377 adult patients with SJS/TEN between 1/1/2000 and 6/1/2015 were entered, including 69.0% from 2010 onward. The most frequent cause of SJS/TEN was medication reaction (89.7%), most often trimethoprim / sulfamethoxazole (27...
May 11, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29749629/decreasing-arsenic-accumulation-in-rice-by-overexpressing-osnip1-1-and-osnip3-3-through-disrupting-arsenite-radial-transport-in-roots
#18
Sheng-Kai Sun, Yi Chen, Jing Che, Noriyuki Konishi, Zhong Tang, Anthony J Miller, Jian Feng Ma, Fang-Jie Zhao
Rice is a major dietary source of the toxic metalloid arsenic. Reducing arsenic accumulation in rice grain is important for food safety. We generated transgenic rice overexpressing two aquaporin genes, OsNIP1;1 and OsNIP3;3, under the control of a maize ubiquitin promoter or the rice OsLsi1 promoter, and tested the effect on arsenite uptake and translocation. OsNIP1;1 and OsNIP3;3 were highly permeable to arsenite in Xenopus oocyte assays. Both transporters were localized at the plasma membrane. Knockout of either gene had little effect on arsenite uptake or translocation...
May 11, 2018: New Phytologist
https://www.readbyqxmd.com/read/29746190/criterion-a-of-the-ampd-in-hitop
#19
Thomas A Widiger, Bo Bach, Michael Chmielewski, Lee Anna Clark, Colin DeYoung, Christopher J Hopwood, Roman Kotov, Robert F Krueger, Joshua D Miller, Leslie C Morey, Stephanie N Mullins-Sweatt, Christopher J Patrick, Aaron L Pincus, Douglas B Samuel, Martin Sellbom, Susan C South, Jennifer L Tackett, David Watson, Mark H Waugh, Aidan G C Wright, Johannes Zimmermann, R Michael Bagby, David C Cicero, Christopher C Conway, Barbara De Clercq, Anna R Docherty, Nicholas R Eaton, Kelsie T Forbush, J D Haltigan, Masha Y Ivanova, Robert D Latzman, Donald R Lynam, Kristian E Markon, Ulrich Reininghaus, Katherine M Thomas
The categorical model of personality disorder classification in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (5th ed. [DSM-5]; American Psychiatric Association, 2013 ) is highly and fundamentally problematic. Proposed for DSM-5 and provided within Section III (for Emerging Measures and Models) was the Alternative Model of Personality Disorder (AMPD) classification, consisting of Criterion A (self-interpersonal deficits) and Criterion B (maladaptive personality traits)...
May 10, 2018: Journal of Personality Assessment
https://www.readbyqxmd.com/read/29742284/associations-among-human-papillomavirus-inflammation-and-fatigue-in-patients-with-head-and-neck-cancer
#20
Canhua Xiao, Jonathan J Beitler, Kristin A Higgins, Toby Glazer, Linh Kha Huynh, Sudeshna Paul, Jennifer C Felger, Evanthia C Wommack, Nabil F Saba, Dong M Shin, Deborah W Bruner, Andrew H Miller
BACKGROUND: Human papillomavirus (HPV) infection has contributed to an increased incidence of squamous cell carcinoma of the head and neck (SCCHN). Fatigue is a major side effect of SCCHN and its treatment. However, to the authors' knowledge, the association between HPV and fatigue has not been examined to date, nor is it known whether HPV influences biological mechanisms of fatigue, including inflammation. METHODS: Patients with SCCHN who were without distant metastasis were assessed at baseline (pre-radiotherapy) and 1 month and 3 months postradiotherapy...
May 9, 2018: Cancer
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