Chien-Chia Chen, Yi-Jen Huang, Mei-Jun Lai, Min-Huey Lin, Wei-Chou Lin, Hui-Ying Lin, Yu-Chun Lin, Yu-Tsung Huang, Ya-Fen Lee, Meng-Kun Tsai, Chih-Yuan Lee
After kidney transplantation, patients exhibit a poor response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. However, the efficacy and adverse effects of vaccines based on different platforms in these patients remain unclear. We prospectively analyzed both anti-spike protein antibody and cellular responses 1 month after the first and second doses of SARS-CoV-2 vaccines in 171 kidney transplant patients. Four vaccines, including one viral vector (ChAdOx1 nCov-19, n = 30), two mRNA (mRNA1273, n = 81 and BNT162b2, n = 38), and one protein subunit (MVC-COV1901, n = 22) vaccines were administered...
2022: Frontiers in Immunology