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https://www.readbyqxmd.com/read/29123464/pattern-separation-a-potential-marker-of-impaired-hippocampal-adult-neurogenesis-in-major-depressive-disorder
#1
Kellen Gandy, Sohye Kim, Carla Sharp, Lilian Dindo, Mirjana Maletic-Savatic, Chadi Calarge
Adult neurogenesis involves the generation of new neurons, particularly in the dentate gyrus of the hippocampus. Decreased hippocampal neurogenesis has been implicated in both animal models of depression and in patients with major depressive disorder (MDD), despite some inconsistency in the literature. Here, we build upon current models to generate a new testable hypothesis, linking impaired neurogenesis to downstream psychological outcomes commonly observed in MDD. We contend that disruption in adult neurogenesis impairs pattern separation, a hippocampus-dependent function requiring the careful discrimination and storage of highly similar, but not identical, sensory inputs...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29106271/developmental-pathways-of-childhood-dark-traits
#2
Barbara De Clercq, Joeri Hofmans, Jasmine Vergauwe, Filip De Fruyt, Carla Sharp
The dark triad of personality has traditionally been defined by 3 interrelated constructs, defined as Narcissism, Machiavellianism, and Psychopathy. Although the content of each of these constructs is clearly represented in childhood maladaptive trait measures, no studies have jointly addressed the prospective developmental course of this core set of maladaptive characteristics throughout childhood and adolescence. The current study uses latent growth modeling to explore how early dark traits develop over time, relying on a selected set of 6 childhood maladaptive traits that conceptually cover the adult dark triad...
October 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29069625/clinical-utility-of-the-dsm-5-alternative-model-for-borderline-personality-disorder-differential-diagnostic-accuracy-of-the-bfi-scid-ii-pq-and-pid-5
#3
J Christopher Fowler, Alok Madan, Jon G Allen, Michelle Patriquin, Carla Sharp, John M Oldham, B Christopher Frueh
BACKGROUND: With the publication of DSM 5 alternative model for personality disorders it is critical to assess the components of the model against evidence-based models such as the five factor model and the DSM-IV-TR categorical model. This study explored the relative clinical utility of these models in screening for borderline personality disorder (BPD). METHODS: Receiver operator characteristics and diagnostic efficiency statistics were calculated for three personality measures to ascertain the relative diagnostic efficiency of each measure...
September 12, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28961663/predictors-of-length-of-stay-in-a-psychiatric-adolescent-treatment-program
#4
Radhika Reddy, Carolyn Ha, Elizabeth Newlin, Carla Sharp
Understanding predictors of adolescent inpatient length of stay (LOS) is important in informing treatment outcomes for this age group. The current literature on adolescent LOS remains limited and has been characterized by methodological limitations. In the study described here, we examined a wide range of predictors for LOS in a psychiatric unit for adolescents (N=285), including severity of disorder (previous hospitalizations, self-harm, cognitive impairment and thought disorder, severe depression, history of trauma), types of psychotropic medication, and diagnoses...
September 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28948864/artificial-neural-network-coding-of-the-child-attachment-interview-using-linguistic-data
#5
Amanda Venta, Ericka Ball Cooper, Yael Shmueli-Goetz, Carla Sharp
Assessing attachment in adolescents is important due to relations between insecurity and psychopathology. The child attachment interview (CAI) holds promise in this regard, but is time-consuming to code, which may render it inaccessible. The aim of this study was to develop computerized neural network models to predict attachment classifications on the CAI and to determine whether the models could achieve the CAI's benchmark qualification of 80% on reliability training cases. Four hundred and ninety interviews from inpatient adolescents served as model training and testing samples...
September 26, 2017: Attachment & Human Development
https://www.readbyqxmd.com/read/28910213/the-challenge-of-transforming-the-diagnostic-system-of-personality-disorders
#6
Sabine C Herpertz, Steven K Huprich, Martin Bohus, Andrew Chanen, Marianne Goodman, Lars Mehlum, Paul Moran, Giles Newton-Howes, Lori Scott, Carla Sharp
While the DSM-5 alternative model of personality disorder (PD) diagnosis allows the field to systematically compare categorical and dimensional classifications, the ICD-11 proposal suggests a radical change by restricting the classification of PDs to one category, deleting all specific types, basing clinical service provision exclusively upon a severity dimension, and restricting trait domains to secondary qualifiers without defining cutoff points. This article reflects broad international agreement about the state of PD diagnosis...
October 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28858660/amygdala-frontal-connectivity-predicts-internalizing-symptom-recovery-among-inpatient-adolescents
#7
Amanda Venta, Carla Sharp, Michelle Patriquin, Ramiro Salas, Elizabeth Newlin, Kaylah Curtis, Philip Baldwin, Christopher Fowler, B Christopher Frueh
BACKGROUND: The possibility of using biological measures to predict the trajectory of symptoms among adolescent psychiatric inpatients has important implications. This study aimed to examine emotion regulation ability (measured via self-report) and a hypothesized proxy in resting-state functional connectivity [RSFC] between the amygdala and frontal brain regions as baseline predictors of internalizing symptom recovery during inpatient care. METHODS: 196 adolescents (61% female; Mage = 15...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28837938/the-relations-between-inadequate-parent-child-boundaries-and-borderline-personality-disorder-in-adolescence
#8
Salome Vanwoerden, Allison Kalpakci, Carla Sharp
Borderline Personality Disorder (BPD) is a severe mental illness that onsets in adolescence. Research has demonstrated the central role of parent-child relationships for the development and maintenance of BPD although more research is necessary to clarify the specific dynamics that relate to BPD during adolescence. Based on preliminary research establishing the importance of parent-child boundaries for adolescent BPD, this study sought to evaluate the relations between different forms of inadequate boundaries and BPD in adolescence using a multi-method approach...
November 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28836093/on-the-relation-between-general-intelligence-and-psychopathic-traits-an-examination-of-inpatient-adolescents
#9
Nicholas Kavish, Cassandra Bailey, Carla Sharp, Amanda Venta
A substantial literature has investigated relations between intelligence and psychopathic traits. At the construct level, findings have been mixed, with a small negative relation found. At the facet level however, a positive relation between verbal intelligence and the interpersonal facet of psychopathy, and a negative relation between verbal intelligence and the lifestyle factor of psychopathy emerge. To date, this research has largely neglected adolescents and prior research has focused on clinical and incarcerated populations, while failing to control for psychopathology...
August 23, 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28833393/aggressive-behaviors-and-suicide-ideation-in-inpatient-adolescents-the-moderating-roles-of-internalizing-symptoms-and-stress
#10
Victor Buitron, Chelsey M Hartley, Jeremy W Pettit, Claire Hatkevich, Carla Sharp
The present study examined a conceptual model in which the association between aggressive behaviors and suicide ideation is moderated by internalizing symptoms and ongoing stress. Participants were 304 psychiatric inpatient adolescents (65.8% girls) ranging in age from 12 to 17 years (Mean age = 14.69). The association between aggressive behaviors and suicide ideation was significantly moderated by internalizing symptoms and ongoing stress; the association was positive in adolescents low in internalizing symptoms or high in ongoing stress, but negative in adolescents high in internalizing symptoms or low in ongoing stress...
August 22, 2017: Suicide & Life-threatening Behavior
https://www.readbyqxmd.com/read/28803040/attachment-and-thought-problems-in-an-adolescent-inpatient-sample-the-mediational-role-of-theory-of-mind
#11
Jessica R Hart, Amanda Venta, Carla Sharp
BACKGROUND: Previous research has documented increased incidence of insecure attachment and theory of mind (ToM) deficits in individuals experiencing psychotic disorders. ToM has been theorized as a possible mediator of the relation between attachment and psychosis (Korver-Nieberg et al., 2014). The current study sought to extend this area of research to adolescents for the first time by examining adolescent-parent attachment and ToM in inpatient adolescents. METHODS: Participants were 362 inpatient adolescents and their parents; participants completed the Child Attachment Interview, Movie for the Assessment of Social Cognition, Youth Self Report, and Child Behavior Checklist...
July 13, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28766998/linguistic-analysis-as-a-method-for-assessing-symptoms-after-sexual-trauma-among-female-adolescent-psychiatric-inpatients
#12
Kaisa Marshall, Amanda Venta, Craig Henderson, Maria Barker, Carla Sharp
Using a sample of female psychiatric inpatient adolescents, the current study aimed to extend this literature to an adolescent sample for the first time by examining if linguistic markers and their subcategories (cognitive process words, pronoun use, and somatosensory detail) in a trauma account are related to trauma symptomology and recovery during inpatient care. Results indicated that greater use of body words and fewer insight words were related to increased trauma symptoms at admission. In addition, use of fewer cognitive process words at admission predicted greater symptom change at discharge, extending previous research findings to an adolescent sample...
August 2, 2017: Journal of Child Sexual Abuse
https://www.readbyqxmd.com/read/28759266/evaluation-of-the-pai-a-anxiety-and-depression-scales-evidence-of-construct-validity
#13
Salome Vanwoerden, Lynne Steinberg, Amelia D Coffman, Daniel J Paulus, Leslie C Morey, Carla Sharp
Against the background of a dearth of studies examining the properties of the scale scores of the Personality Assessment Inventory-Adolescent (PAI-A; Morey, 2007), this study was conducted to evaluate evidence of construct validity for the Anxiety (ANX) and Depression (DEP) scales of the PAI-A. Convergent and discriminant validity of the ANX and DEP scale scores were investigated using a sample of adolescents admitted to the adolescent program of a private tertiary care inpatient treatment facility. Multiple methods assessing anxious and depressive symptomology and diagnoses were included...
July 31, 2017: Journal of Personality Assessment
https://www.readbyqxmd.com/read/28601718/the-columbia-suicide-severity-rating-scale-associations-between-interrupted-aborted-and-actual-suicide-attempts-among-adolescent-inpatients
#14
Ryan M Hill, Claire E Hatkevich, Iram Kazimi, Carla Sharp
The Columbia-Suicide Severity Rating Scale divides suicide attempt behaviors into actual, interrupted, and aborted attempts, but limited data have been reported regarding associations between interrupted, aborted, and actual attempts. This study provided initial data on the ability of interrupted and aborted attempts to estimate the frequency of actual suicide attempts. Participants were adolescent psychiatric inpatients (59.9% female), 12-17 years (mean = 14.73, SD = 1.62). Results suggest that interrupted and aborted suicide attempts are associated with the frequency of actual suicide attempts, controlling for suicidal ideation and depressive symptoms...
September 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28442271/evaluation-of-the-xpert-hcv-viral-load-point-of-care-assay-from-venepuncture-collected-and-finger-stick-capillary-whole-blood-samples-a-cohort-study
#15
Jason Grebely, Francois M J Lamoury, Behzad Hajarizadeh, Yasmin Mowat, Alison D Marshall, Sahar Bajis, Philippa Marks, Janaki Amin, Julie Smith, Michael Edwards, Carla Gorton, Nadine Ezard, David Persing, Marika Kleman, Philip Cunningham, Beth Catlett, Gregory J Dore, Tanya L Applegate
BACKGROUND: Point-of-care hepatitis C virus (HCV) RNA testing offers an advantage over antibody testing (which only indicates previous exposure), enabling diagnosis of active infection in a single visit. In this study, we evaluated the performance of the Xpert HCV Viral Load assay with venepuncture and finger-stick capillary whole-blood samples. METHODS: Plasma and finger-stick capillary whole-blood samples were collected from participants in an observational cohort enrolled at five sites in Australia (three drug and alcohol clinics, one homelessness service, and one needle and syringe programme)...
April 21, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28238273/a-novel-approach-to-identifying-a-neuroimaging-biomarker-for-patients-with-serious-mental-illness
#16
Alok Madan, J Christopher Fowler, Michelle A Patriquin, Ramiro Salas, Philip R Baldwin, Kenia M Velasquez, Humsini Viswanath, David L Molfese, Carla Sharp, Jon G Allen, Susan Hardesty, John M Oldham, B Christopher Frueh
Serious mental illness (SMI) is disabling, and current interventions are ineffective for many. This exploratory study sought to demonstrate the feasibility of applying topological data analysis (TDA) to resting-state functional connectivity data obtained from a heterogeneous sample of 235 adult inpatients to identify a biomarker of treatment response. TDA identified two groups based on connectivity between the prefrontal cortex and striatal regions: patients admitted with greater functional connectivity between these regions evidenced less improvement from admission to discharge than patients with lesser connectivity between them...
February 27, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28211278/endoscopic-removal-of-multiple-sharp-gastro-duodenal-foreign-bodies
#17
Samuel Costa, Raquel Gonçalves, Carla Rolanda
A 45 years old female,with bipolar disorder,was brought to the Emergency Department with abdominal pain. The patient was hemodynamically stable,with no signs of respiratory distress. On abdominal examination she had pain in the upper quadrants,without peritoneal irritation. The successful endoscopic removal decreases if delayed approach, beyond 12 h, and sharp objects. Moreover in case of sharp objects, even if already into the stomach or duodenum, they should be retrieved endoscopically if it can be accomplished safely, because the risk of a complication during its natural exteriorization is as high as 35%...
February 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28176177/trauma-and-aggression-investigating-the-mediating-role-of-mentalizing-in-female-and-male-inpatient-adolescents
#18
Anna Abate, Kaisa Marshall, Carla Sharp, Amanda Venta
High rates of posttraumatic stress disorder (PTSD) symptoms and elevated levels of aggression are common among youth in inpatient psychiatric settings. Several models link trauma exposure to aggression through anomalous mental state reasoning. Some theoretical frameworks linking trauma to aggression specify that the over-attribution of hostile mental states contributes to the development of aggressive behavior whereas other theories suggest that an inhibition of mental state reasoning leads to aggressive behavior...
December 2017: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/28078089/the-specificity-of-emotion-dysregulation-in-adolescents-with-borderline-personality-disorder-comparison-with-psychiatric-and-healthy-controls
#19
Marina Ibraheim, Allison Kalpakci, Carla Sharp
BACKGROUND: Research has supported the notion that emotion dysregulation is a core feature of BPD. However, given that this feature is typical of healthy adolescents as well as adolescents with other psychiatric disorders, the specificity of emotion dysregulation to BPD in this age group has not yet been determined. The overall aim of this study was to examine emotion dysregulation in adolescent inpatients with BPD compared with non-BPD inpatient adolescents and healthy non-clinical adolescents, taking into account both global emotion dysregulation deficits and more specific impairments...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/28072043/compelled-to-risk-does-sexual-compulsivity-explain-the-connection-between-borderline-personality-disorder-features-and-number-of-sexual-partners
#20
Charles Jardin, Carla Sharp, Lorra Garey, Salome Vanwoerden, Nic Crist, Jon D Elhai, Michael J Zvolensky
Having more sexual partners increases the likelihood of new HIV infections among women. Women with more borderline personality disorder (BPD) features have been known to have greater numbers of sexual partners. However, the mechanisms linking BPD features with more sexual partners remain to be clarified. Sexual compulsivity (lack of control, increased distress over sexual behavior) may be one such explanatory factor, as it overlaps with BPD features (e.g., impulsivity, negative affectivity). The present study examined whether sexual compulsivity explained the relation of BPD features with number of sexual partners among a diverse sample of college females (N = 1,326)...
January 10, 2017: Journal of Personality Disorders
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