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https://www.readbyqxmd.com/read/28437835/pten-downregulation-promotes-%C3%AE-oxidation-to-fuel-hypertrophic-liver-growth-after-hepatectomy-in-mice
#1
Ekaterina Kachaylo, Christoph Tschuor, Nicolas Calo, Nathalie Borgeaud, Perparim Limani, Anne-Christine Piguet, Jean-Francois Dufour, Michelangelo Foti, Rolf Graf, Pierre A Clavien, Bostjan Humar
In regenerating liver, hepatocytes accumulate lipids before the major wave of parenchymal growth. This transient, regeneration-associated steatosis (TRAS) is required for liver recovery, but its purpose is unclear. The tumor suppressor PTEN is a key inhibitor of the AKT-mTOR axis that regulates growth and metabolic adaptations after hepatectomy. In quiescent liver, PTEN causes pathological steatosis when lost, while its role in regenerating liver remains unknown. Here, we show that PTEN downregulation promotes liver growth in a TRAS-dependent way...
April 24, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28437804/-prognostic-factors-of-open-abdomen-treatment-in-visceral-surgery
#2
Martin W von Websky, Agnes Jedig, Arnulf Willms, Azin Jafari, Hanno Matthaei, Jörg C Kalff, Steffen Manekeller
Introduction In general surgery, open abdomen treatment (OAT) is used to treat abdominal compartment syndrome (ACS) and sepsis, often after a primary surgical procedure associated with complications. The results achieved in this patient population may depend on factors that are yet unknown. This study evaluates independent patient-related prognostic factors after OAT. Methods 38 clinical parameters and survival data of 165 consecutive general surgery patients after OAT were entered into a prospective database according to a defined algorithm in order to analyse the underlying surgical pathology, predictors of survival and important aspects of OAT-related morbidity...
April 24, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28437795/effect-of-using-the-heart-score-in-patients-with-chest-pain-in-the-emergency-department-a-stepped-wedge-cluster-randomized-trial
#3
Judith M Poldervaart, Johannes B Reitsma, Barbra E Backus, Hendrik Koffijberg, Rolf F Veldkamp, Monique E Ten Haaf, Yolande Appelman, Herman F J Mannaerts, Jan-Melle van Dantzig, Madelon van den Heuvel, Mohamed El Farissi, Bernard J W M Rensing, Nicolette M S K J Ernst, Ineke M C Dekker, Frank R den Hartog, Thomas Oosterhof, Ghizelda R Lagerweij, Eugene M Buijs, Maarten W J van Hessen, Marcel A J Landman, Roland R J van Kimmenade, Luc Cozijnsen, Jeroen J J Bucx, Clara E E van Ofwegen-Hanekamp, Maarten-Jan Cramer, A Jacob Six, Pieter A Doevendans, Arno W Hoes
Background: The HEART (History, Electrocardiogram, Age, Risk factors, and initial Troponin) score is an easy-to-apply instrument to stratify patients with chest pain according to their short-term risk for major adverse cardiac events (MACEs), but its effect on daily practice is unknown. Objective: To measure the effect of use of the HEART score on patient outcomes and use of health care resources. Design: Stepped-wedge, cluster randomized trial...
April 25, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28437745/comparative-study-of-the-effects-of-gadolinium-chloride-and-gadolinium-based-magnetic-resonance-imaging-contrast-agent-on-freshwater-mussel-dreissena-plymorpha
#4
Houda Hanana, Patrice Turcotte, Chantale André, Christian Gagnon, François Gagné
Gadolinium (Gd), a metal of the lanthanide series used in various industrial and medical purposes is released into the aquatic environment. However, there are few aquatic toxicological studies addressing environmental effects of Gd which remains unknown in aquatic animals. Therefore, this study aimed to compare the effects of GdCl3 and a gadolinium-based MRI contrast agent (Omniscan), in zebra mussels after 28 days through a multibiomarker approach. Data revealed that after GdCl3 exposure, the mRNA level of metallothionein (MT) was modulated, those of cytochrome c oxidase (CO1) and superoxide dismutase (SOD) were increased, while gene expressions of catalase (CAT) and glutathione-S-transferase (GST) were downregulated...
April 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28437738/simultaneous-spectrophotometric-determination-of-glimepiride-and-pioglitazone-in-binary-mixture-and-combined-dosage-form-using-chemometric-assisted-techniques
#5
Asmaa A El-Zaher, Ehab F Elkady, Hanan M Elwy, Mahmoud Abo El Makarim Saleh
In the present work, pioglitazone and glimepiride, 2 widely used antidiabetics, were simultaneously determined by a chemometric-assisted UV-spectrophotometric method which was applied to a binary synthetic mixture and a pharmaceutical preparation containing both drugs. Three chemometric techniques - Concentration residual augmented classical least-squares (CRACLS), principal component regression (PCR), and partial least-squares (PLS) were implemented by using the synthetic mixtures containing the two drugs in acetonitrile...
March 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28437695/fe-iii-promoted-transformation-of-%C3%AE-lactam-antibiotics-hydrolysis-vs-oxidation
#6
Jiabin Chen, Ying Wang, Yajie Qian, Tianyin Huang
The widely used β-lactam antibiotics are susceptible to oxidative and/or hydrolytic degradation promoted by some metal ions (e.g., Cu(II)). Ferric ions (Fe(III)) are among the most common metal ions, but their role in the environmental transformation and fate of β-lactam antibiotics is still unknown. This study elucidates that Fe(III) can promote degradation of β-lactam antibiotics under environmental aquatic conditions. Degradation rate constants of ampicillin (AMP) linearly increased with increasing Fe(III) concentration, but were independent of AMP concentration when AMP was higher than Fe(III) concentration...
April 6, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28437685/rapid-label-free-identification-of-klebsiella-pneumoniae-antibiotic-resistant-strains-by-the-drop-coating-deposition-surface-enhanced-raman-scattering-method
#7
Youjin Cheong, Young Jin Kim, Heeyoon Kang, Samjin Choi, Hee Joo Lee
Although many methodologies have been developed to identify unknown bacteria, bacterial identification in clinical microbiology remains a complex and time-consuming procedure. To address this problem, we developed a label-free method for rapidly identifying clinically relevant multilocus sequencing typing-verified quinolone-resistant Klebsiella pneumoniae strains. We also applied the method to identify three strains from colony samples, ATCC70063 (control), ST11 and ST15; these are the prevalent quinolone-resistant K...
April 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28437605/aqueously-released-graphene-oxide-embedded-in-epoxy-resin-exhibits-different-characteristics-and-phytotoxicity-of-chlorella-vulgaris-from-the-pristine-form
#8
Xiangang Hu, Weilu Kang, Li Mu
The environmental release of nanoparticles is attracting increasing attention. Graphene oxide (GO) embedded in epoxy resin (ER) is a popular composite that has been used in various fields, but the environmental release of GO-ER composites and the effects on organisms in the environment remain unknown. The present work found that GO-ER composites in water for 2-7 days resulted in the release of 0.3-2.1% GO-ER at nanoscale (2-3 nm thickness and approximately 70-130 nm lateral length). Interestingly, pristine GO quenched 30-45% hydroxyl and 12% nitroxide free radicals, whereas this capacity was not observed for the released particles from GO-ER...
April 24, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28437604/antiplasmodial-mode-of-action-of-pantothenamides-pantothenate-kinase-serves-as-a-metabolic-activator-not-as-a-target
#9
Marianne de Villiers, Christina Spry, Cristiano Joao Macuamule, Leanne Barnard, Gordon Wells, Kevin J Saliba, Erick Strauss
N-substituted pantothenamides (PanAms) are pantothenate analogues with up to nanomolar potency against blood-stage Plasmodium falciparum (the most virulent species responsible for malaria). Although these compounds are known to target coenzyme A (CoA) biosynthesis and/or utilization, their exact mode of action (MoA) is still unknown. Importantly, PanAms that retain the natural β-alanine moiety are more potent than other variants, consistent with the involvement of processes that are selective for pantothenate (the precursor of CoA) or its derivatives...
April 24, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28437597/weight-loss-in-weight-watchers-online-with-and-without-an-activity-tracking-device-compared-to-control-a-randomized-trial
#10
J Graham Thomas, Hollie A Raynor, Dale S Bond, Anna K Luke, Chelsi C Cardoso, Gary D Foster, Rena R Wing
OBJECTIVE: To evaluate a commercial online weight loss program and activity tracker, which are popular but have unknown efficacy. METHODS: Two hundred seventy-nine participants with BMI 27 to 40 kg/m(2) were randomized to 12 months of the Weight Watchers Online program alone (WWO) or with the ActiveLink(®) activity tracking device (WWO+AL) or an online newsletter (Control). RESULTS: Weight losses at 3 months were significantly greater in WWO (2...
April 24, 2017: Obesity
https://www.readbyqxmd.com/read/28437593/tabula-rasa-in-the-patagonian-channels-the-phylogeography-of-oreobolus-obtusangulus-cyperaceae
#11
Simon Pfanzelt, Dirk C Albach, Klaus Bernhard von Hagen
The extent of the Pleistocene glaciations in the Patagonian Channel region (southwesternmost South America) and their impact on the vegetation there is largely unknown. Whether the regional flora was wiped out completely (tabula rasa) or survived in ice-free pockets (in situ survival) is still an open question. The molecular imprint of either scenario should still be visible in extant populations. Therefore, DNA sequence data of Oreobolus obtusangulus Gaudich. (Cyperaceae) were analyzed. This species is an abundant constitutent of Patagonian cushion peat bogs, one of the Patagonian Channel region's major vegetation types...
April 24, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28437587/relationship-type-affects-the-reliability-of-dispersal-distance-estimated-using-pedigree-inferences-in-partially-sampled-populations-a-case-study-involving-invasive-american-mink-in-scotland
#12
Y Melero, M K Oliver, X Lambin
Estimating dispersal - a key parameter for population ecology and management - is notoriously difficult. The use of pedigree assignments, aided by likelihood-based softwares, has become popular to estimate dispersal rate and distance. However, the partial sampling of populations may produce false assignments. Further, it is unknown how the accuracy of assignment is affected by the genealogical relationships of individuals and is reflected by software-derived assignment probabilities. Inspired by a project managing invasive American mink (Neovison vison), we estimated individual dispersal distances using inferred pairwise relationships of culled individuals...
April 24, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28437543/association-of-donor-age-and-sex-with-survival-of-patients-receiving-transfusions
#13
Gustaf Edgren, Henrik Ullum, Klaus Rostgaard, Christian Erikstrup, Ulrik Sartipy, Martin J Holzmann, Olof Nyrén, Henrik Hjalgrim
Importance: Following animal model data indicating the possible rejuvenating effects of blood from young donors, there have been at least 2 observational studies conducted with humans that have investigated whether donor age affects patient outcomes. Results, however, have been conflicting. Objective: To study the association of donor age and sex with survival of patients receiving transfusions. Design, Setting, and Participants: A retrospective cohort study based on the Scandinavian Donations and Transfusions database, with nationwide data, was conducted for all patients from Sweden and Denmark who received at least 1 red blood cell transfusion of autologous blood or blood from unknown donors between January 1, 2003, and December 31, 2012...
April 24, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28437526/prominin-1-is-a-novel-regulator-of-autophagy-in-the-human-retinal-pigment-epithelium
#14
Sujoy Bhattacharya, Jinggang Yin, Christina S Winborn, Qiuhua Zhang, Junming Yue, Edward Chaum
Purpose: Prominin-1 (Prom1) is a transmembrane glycoprotein, which is expressed in stem cell lineages, and has recently been implicated in cancer stem cell survival. Mutations in the Prom1 gene have been shown to disrupt photoreceptor disk morphogenesis and cause an autosomal dominant form of Stargardt-like macular dystrophy (STGD4). Despite the apparent structural role of Prom1 in photoreceptors, its role in other cells of the retina is unknown. The purpose of this study is to investigate the role of Prom1 in the highly metabolically active cells of the retinal pigment epithelium (RPE)...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28437523/emergency-department-query-for-patient-centered-approaches-to-sexual-orientation-and-gender-identity-the-equality-study
#15
Adil H Haider, Eric B Schneider, Lisa M Kodadek, Rachel R Adler, Anju Ranjit, Maya Torain, Ryan Y Shields, Claire Snyder, Jeremiah D Schuur, Laura Vail, Danielle German, Susan Peterson, Brandyn D Lau
Importance: The Institute of Medicine and The Joint Commission recommend routine documentation of patients' sexual orientation in health care settings. Currently, very few health care systems collect these data since patient preferences and health care professionals' support regarding collection of data about patient sexual orientation are unknown. Objective: To identify the optimal patient-centered approach to collect sexual orientation data in the emergency department (ED) in the Emergency Department Query for Patient-Centered Approaches to Sexual Orientation and Gender Identity study...
April 24, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28437467/mutant-uromodulin-expression-leads-to-altered-homeostasis-of-the-endoplasmic-reticulum-and-activates-the-unfolded-protein-response
#16
Céline Schaeffer, Stefania Merella, Elena Pasqualetto, Dejan Lazarevic, Luca Rampoldi
Uromodulin is the most abundant urinary protein in physiological conditions. It is exclusively produced by renal epithelial cells lining the thick ascending limb of Henle's loop (TAL) and it plays key roles in kidney function and disease. Mutations in UMOD, the gene encoding uromodulin, cause autosomal dominant tubulointerstitial kidney disease uromodulin-related (ADTKD-UMOD), characterised by hyperuricemia, gout and progressive loss of renal function. While the primary effect of UMOD mutations, retention in the endoplasmic reticulum (ER), is well established, its downstream effects are still largely unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28437447/carbonic-anhydrase-iii-car3-is-not-required-for-fatty-acid-synthesis-and-does-not-protect-against-high-fat-diet-induced-obesity-in-mice
#17
Sarah W Renner, Lauren M Walker, Lawrence J Forsberg, Jonathan Z Sexton, Jay E Brenman
Carbonic anhydrases are a family of enzymes that catalyze the reversible condensation of water and carbon dioxide to carbonic acid, which spontaneously dissociates to bicarbonate. Carbonic anhydrase III (Car3) is nutritionally regulated at both the mRNA and protein level. It is highly enriched in tissues that synthesize and/or store fat: liver, white adipose tissue, brown adipose tissue, and skeletal muscle. Previous characterization of Car3 knockout mice focused on mice fed standard diets, not high-fat diets that significantly alter the tissues that highly express Car3...
2017: PloS One
https://www.readbyqxmd.com/read/28437439/landscape-and-environmental-influences-on-mycobacterium-ulcerans-distribution-among-aquatic-sites-in-ghana
#18
Shannon M Pileggi, Heather Jordan, Julie A Clennon, Ellen Whitney, M Eric Benbow, Richard Merritt, Mollie McIntosh, Ryan Kimbirauskas, Pamela Small, Daniel Boakye, Charles Quaye, Jiaguo Qi, Lindsay Campbell, Jenni Gronseth, Edwin Ampadu, William Opare, Lance A Waller
Buruli ulcer, caused by Mycobacterium ulcerans, is highly endemic in West Africa. While the mode of transmission is unknown, many studies associate Buruli ulcer with different types of water exposure. We present results from the largest study to date to test for M. ulcerans in aquatic sites and identify environmental attributes associated with its presence. Environmental samples from 98 aquatic sites in the Greater Accra, Ashanti, and Volta regions of Ghana were tested for the presence of M. ulcerans DNA by polymerase chain reaction...
2017: PloS One
https://www.readbyqxmd.com/read/28437431/factors-associated-with-acquired-anti-ifn-%C3%AE-autoantibody-in-patients-with-nontuberculous-mycobacterial-infection
#19
Pakpoom Phoompoung, Nasikarn Ankasekwinai, Manop Pithukpakorn, Suporn Foongladda, Pinklow Umrod, Bhoom Suktitipat, Surakameth Mahasirimongkol, Sasisopin Kiertiburanakul, Yupin Suputtamongkol
BACKGROUND: The clinical syndrome of disseminated nontuberculous mycobacterial (NTM) infection in patients who were previously healthy is now well recognized to be associated with an acquired autoantibody to Interferon gamma (Anti IFN- γ autoantibody). However, the risk factors of this syndrome remain unknown. METHOD: We performed an unmatched case control study among patients with NTM diseases who were diagnosed and treated at Siriraj Hospital, Bangkok, Thailand...
2017: PloS One
https://www.readbyqxmd.com/read/28437360/dna-hydroxymethylation-by-ten-eleven-translocation-methylcytosine-dioxygenase-1-and-3-regulates-nociceptive-sensitization-in-a-chronic-inflammatory-pain-model
#20
Zhiqiang Pan, Zhou-Ya Xue, Guo-Fang Li, Meng-Lan Sun, Ming Zhang, Ling-Yun Hao, Qian-Qian Tang, Li-Jiao Zhu, Jun-Li Cao
BACKGROUND: Ten-eleven translocation methylcytosine dioxygenase converts 5-methylcytosine in DNA to 5-hydroxymethylcytosine, which plays an important role in gene transcription. Although 5-hydroxymethylcytosine is enriched in mammalian neurons, its regulatory function in nociceptive information processing is unknown. METHODS: The global levels of 5-hydroxymethylcytosine and ten-eleven translocation methylcytosine dioxygenase were measured in spinal cords in mice treated with complete Freund's adjuvant...
April 24, 2017: Anesthesiology
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