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https://www.readbyqxmd.com/read/29341882/development-and-evaluation-of-a-website-for-surveillance-of-healthcare-associated-urinary-tract-infections-in-australia
#1
Oyebola Fasugba, Jane Koerner, Noleen Bennett, Simon Burrell, Roland Laguitan, Alex Hoskins, Wendy Beckingham, Brett G Mitchell, Anne Gardner
Phase II of the Surveillance to Reduce Urinary Tract Infections project piloted a website for point prevalence surveys of healthcare-associated (HAUTI) and catheter-associated urinary tract infection in Australian hospitals and aged care homes. This study describes development and evaluation of the website for online data collection. Evaluation findings from 38 data collectors indicated most respondents found website registration and web form use easy (n=22; 58% and n=16; 43%, respectively). The need for improved computer literacy skills and automated data systems were highlighted...
January 13, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29340897/invasion-and-translocation-of-uropathogenic-escherichia-coli-isolated-from-urosepsis-and-patients-with-community-acquired-urinary-tract-infection
#2
B Owrangi, N Masters, A Kuballa, C O'Dea, T L Vollmerhausen, M Katouli
Uropathogenic Escherichia coli (UPEC) strains are found in high numbers in the gut of patients with urinary tract infections (UTIs). We hypothesised that in hospitalised patients, UPEC strains might translocate from the gut to the blood stream and that this could be due to the presence of virulence genes (VGs) that are not commonly found in UPEC strains that cause UTI only. To test this, E. coli strains representing 75 dominant clonal groups of UPEC isolated from the blood of hospitalised patients with UTI (urosepsis) (n = 22), hospital-acquired (HA) UTI without blood infection (n = 24) and strains isolated from patients with community-acquired (CA)-UTIs (n = 29) were tested for their adhesion to, invasion and translocation through Caco-2 cells, in addition to the presence of 34 VGs associated with UPEC...
January 16, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29339564/accuracy-of-the-urinalysis-for-urinary-tract-infections-in-febrile-infants-60-days-and-younger
#3
Leah Tzimenatos, Prashant Mahajan, Peter S Dayan, Melissa Vitale, James G Linakis, Stephen Blumberg, Dominic Borgialli, Richard M Ruddy, John Van Buren, Octavio Ramilo, Nathan Kuppermann
OBJECTIVES: Reports of the test accuracy of the urinalysis for diagnosing urinary tract infections (UTIs) in young febrile infants have been variable. We evaluated the test characteristics of the urinalysis for diagnosing UTIs, with and without associated bacteremia, in young febrile infants. METHODS: We performed a planned secondary analysis of data from a prospective study of febrile infants ≤60 days old at 26 emergency departments in the Pediatric Emergency Care Applied Research Network...
January 16, 2018: Pediatrics
https://www.readbyqxmd.com/read/29339395/efficacy-and-safety-of-finafloxacin-versus-ciprofloxacin-in-the-treatment-of-complicated-urinary-tract-infections-an-explorative-randomized-phase-ii-clinical-study
#4
F Wagenlehner, M Nowicki, C Bentley, M Lückermann, S Wohlert, C Fischer, A Vente, K Naber, A Dalhoff
INTRODUCTION: The broad spectrum C-8-cyano-fluoroquinolone finafloxacin displays enhanced activity at acidic conditions. This phase II clinical study compared efficacy and safety of finafloxacin and ciprofloxacin in patients with complicated urinary tract infection and/or pyelonephritis. RESULTS: A 5-day regimen with finafloxacin 800 mg q.d. (FINA05) had similar results as a 10-day regimen with finafloxacin 800 mg q.d. (FINA10). Combined microbiological and clinical responses at test of cure visit (TOC) were 70% for FINA05, 68% for FINA10, and 57% for a 10-day ciprofloxacin regimen (CIPRO10) in 193 (64 for FINA05, 68 for FINA10 and 61 for CIPRO10) patients of the microbiological intent-to-treat (mITT) population...
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29339394/population-pharmacokinetics-of-finafloxacin-in-healthy-volunteers-and-patients-with-complicated-urinary-tract-infections
#5
Max Taubert, Mark Lückermann, Andreas Vente, Axel Dalhoff, Uwe Fuhr
Background: Finafloxacin is a novel fluoroquinolone with increased antibacterial activity at acidic pH and reduced susceptibility to several resistance mechanisms. A phase II study revealed a good efficacy/safety profile in patients with complicated urinary tract infections (cUTI) while pharmacokinetics was characterized by highly variable concentration vs. time profiles, suggesting the need for an elaborated pharmacokinetic model.Methods: Data from three clinical trials were evaluated; 127 healthy volunteers were dosed orally (N=77) or intravenously (N=50) and 139 patients with cUTI received finafloxacin intravenously...
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29339393/early-clinical-assessment-of-the-antimicrobial-activity-of-finafloxacin-compared-to-ciprofloxacin-in-sub-sets-of-microbiologically-characterized-isolates
#6
Andreas Vente, Christine Bentley, Mark Lückermann, Paul Tambyah, Axel Dalhoff
INTRODUCTION: Two phase II studies were performed in patients with uncomplicated (uUTI) and complicated urinary tract infections or acute pyelonephritis (cUTI/PN) to compare finafloxacin (300 mg b.i.d, p.o. for uUTI 800 mg q.d., i.v. for cUTI/PN) and ciprofloxacin (250 mg b.i.d, p.o. for uUTI and 400 mg b.i.d., i.v. for cUTI/PN). The early response to the study medications was evaluated in the microbiological-intent-to treat population (mITT) at day 3. RESULTS: 21% of the isolates were ciprofloxacin-resistant, 13...
January 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29338914/prophylactic-antibiotics-following-radical-cystectomy-reduces-urinary-tract-infections-and-readmission-for-sepsis-from-a-urinary-source
#7
Ryan P Werntz, Ann Martinez-Acevedo, Hamed Amadi, Ryan Kopp, Jeffrey La Rochelle, Theresa Koppie, Christopher Amling, Kamran P Sajadi
INTRODUCTION: Urinary tract infections (UTI) and sepsis contribute significantly to the morbidity associated with cystectomy and urinary diversion in the first 30 days. We hypothesized that continuous antibiotic prophylaxis decreased UTIs in the first 30 days following radical cystectomy. METHODS: Patients with urothelial carcinoma of the bladder who underwent a radical cystectomy with urinary diversion for bladder cancer at Oregon Health and Science University from January 2014 to May 2015 were included in the study...
January 12, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29338897/asymptomatic-bacteriuria-and-urinary-tract-infection-in-pregnant-women-with-and-without-diabetes-cohort-study
#8
Caroline Schneeberger, Jan Jaap H M Erwich, Edwin R van den Heuvel, Ben W J Mol, Alewijn Ott, Suzanne E Geerlings
OBJECTIVE: To compare the prevalence of asymptomatic bacteriuria (ASB) and the incidence of urinary tract infection (UTI) in pregnant women with and without diabetes mellitus (DM) or gestational DM (GDM). STUDY DESIGN: We performed a cohort study in five hospitals and two midwifery clinics in the Netherlands. Pregnant women with and without DM or GDM were screened for the presence of ASB around 12 and 32 weeks' gestation. Characteristics of participants as well as outcome data were collected from questionnaires and medical records...
December 7, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29338688/transurethral-resection-of-the-prostate-provides-more-favorable-clinical-outcomes-compared-with-conservative-medical-treatment-in-patients-with-urinary-retention-caused-by-benign-prostatic-obstruction
#9
Yu-Hsiang Lin, Chen-Pang Hou, Tien-Hsing Chen, Horng-Heng Juang, Phei-Lang Chang, Pei-Shan Yang, Chien-Lun Chen, Ke-Hung Tsui
BACKGROUND: To evaluate the long-term surgical outcomes of patients with urinary retention (UR) caused by a benign prostatic obstruction (BPO) who underwent transurethral resection of the prostate (TURP), and compare their outcomes with those of patients who received medication without surgical intervention. METHODS: This retrospective cohort study analyzed claims data collected during the period of 1997-2012 from Taiwan's National Health Insurance Research Database...
January 16, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29337128/-estimating-minimum-period-of-time-to-perform-prostate-mri-after-prostate-biopsy-clinical-and-histological-bleeding-risk-factors-from-a-prospective-study
#10
M Sarradin, C Lepiney, O Celhay, P O Delpech, T Charles, P Pillot, S Bernardeau, J P Tasu, J Irani
A minimum delay of 4 to 6 weeks between biopsy and multiparametric prostatic MRI (mpMRI) is admitted due to post-biopsy hemorrhage that can impact MRI reading without strong scientific evidence. The objective of the study was to evaluate the best period between prostate biopsy and 3Tesla mpMRI and searching for predictive factors of intraprostatic blood. A prostate biopsy followed by a 4-week prostate MRI (MRIp M1) was performed. In case of hemorrhage, MRI was rescheduled at 8 and 12 weeks (M2/M3). We analyzed the persistant bleeding to identify risk factors: anticoagulant/antiaggregant, post-biopsy side effects, histological criteria...
January 11, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29337127/-epidemiology-of-emergency-consultations-for-acute-urine-retention
#11
J Gas, A Liaigre-Ramos, J B Beauval, M Roumiguié, V Tostivint, P-M Patard, E Huyghe, M Soulié, S Charpentier, X Gamé
INTRODUCTION: Acute urinary retention (AUR) is a common reason for emergency consultation. It may be spontaneous or precipitated and affects both men and women. The purpose of this study was to determine the profile of men visiting emergency departments for an AUR. MATERIEL AND METHODS: A retrospective monocentric study including all men who consulted the emergency department between January 2014 and December 2016 for AUR was conducted. RESULTS: In 3 years, 731 patients were admitted for AUR (611 men and 120 women)...
January 11, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29335323/antibiotic-prescribing-quality-for-children-in-primary-care-an-observational-study
#12
Megan Rose Williams, Giles Greene, Gurudutt Naik, Kathryn Hughes, Christopher C Butler, Alastair D Hay
BACKGROUND: Overuse and inappropriate prescribing of antibiotics is driving antibiotic resistance. GPs often prescribe antibiotics for upper respiratory tract infections (URTIs) in young children despite their marginal beneficial effects. AIM: To assess the quality of antibiotic prescribing for common infections in young children attending primary care and to investigate influencing factors. DESIGN AND SETTING: An observational, descriptive analysis, including children attending primary care sites in England and Wales...
January 15, 2018: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29333822/labial-adhesions-experience-in-a-children-s-hospital
#13
Anahí Rubinstein, Gisel Rahman, Paula Risso, Dolores Ocampo
Labial adhesions are defined as the complete or partial fusion of the pudendal cleft due to the agglutination of the labia minora in the midline. They most commonly occur between 3 months and 6 years of life. Between January 1st, 2002 and December 31st, 2015, 425 girls diagnosed with labial adhesions and seen at the Unit of Pediatric and Adolescent Gynecology of Hospital de Niños de La Plata, Argentina, were analyzed. Their average age was 2.7 years (standard deviation: 2.6 years). The most common presentation of labial adhesions was that involving more than 75% of the total length of the labia (p < 0...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29333509/rate-and-association-of-lower-urinary-tract-infection-with-recurrence-after-transurethral-resection-of-bladder-tumor
#14
Byung Soo Kim, Bum Sik Tae, Ja Hyeon Ku, Cheol Kwak, Hyeon Hoe Kim, Chang Wook Jeong
Purpose: To evaluate the rate of pyuria and bacteriuria after transurethral resection of bladder tumor (TURBT). Materials and Methods: We retrospectively evaluated data obtained from 363 patients who underwent TURBT between October 2012 and December 2013 at Seoul National University Hospital. Urinalysis and urine culture were assessed at 3, 6, 12, and 24 months postoperatively. Primary endpoint was the rate of bacteriuria (≥105/mL in a midstream) and pyuria (white blood cells ≥5/high-power field)...
January 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29332116/applying-preventive-measures-leading-to-significant-reduction-of-catheter-associated-urinary-tract-infections-in-adult-intensive-care-unit
#15
Fahad M Al-Hameed, Gulam R Ahmed, Asim A AlSaedi, Muhammad J Bhutta, Faisal F Al-Hameed, Majid M AlShamrani
To determine the impact of applying the best available clinical evidence on the preventive measures to reduce the rate of catheter-associated urinary tract infections (CAUTI) in adult intensive care units (ICU).     Methods:  Data were collected from adult ICUs (28 beds) from 2008 to 2016. The proper use of silicon catheter, aseptic insertion technique, emptying bag three-fourth via close circuit, the use of appropriate size catheter, securing the draining tube on the thigh to keep catheter bag below patient's bladder level and removal of the catheter as early as possible were ensured in all patients...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29331548/effect-of-outpatient-antibiotics-for-urinary-tract-infections-on-antimicrobial-resistance-among-commensal-enterobacteriaceae-a-multinational-prospective-cohort-study
#16
Andrew J Stewardson, Jascha Vervoort, Niels Adriaenssens, Samuel Coenen, Maciek Godycki-Cwirko, Anna Kowalczyk, Benedikt Huttner, Christine Lammens, Surbhi Malhotra-Kumar, Herman Goossens, Stephan Harbarth
OBJECTIVES: We quantified the impact of antibiotics prescribed in primary care for urinary tract infections (UTIs) on intestinal colonisation by ciprofloxacin-resistant (CIP-RE) and extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE), while accounting for household clustering. METHODS: Prospective cohort study from January 2011 to August 2013 at primary care sites in Belgium, Poland and Switzerland. We recruited outpatients requiring antibiotics for suspected UTIs or asymptomatic bacteriuria (exposed patients), outpatients not requiring antibiotics (non-exposed patients), and 1-3 household contacts for each patient...
January 10, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29331047/the-economic-burden-of-overactive-bladder-in-the-united-states-a-systematic-literature-review
#17
REVIEW
Lauren C Powell, Shelagh M Szabo, David Walker, Katherine Gooch
AIMS: Overactive bladder (OAB) affects up to 17% of the United States (US) population. This study aimed to synthesize estimates of direct and indirect costs of OAB in the US and compare costs among those with and without OAB. METHODS: A systematic review was performed using MEDLINE/PubMed and Embase, from 2003 to 2016, following PRISMA guidelines. The target population was adults with idiopathic OAB or urge urinary incontinence from the US. Data were extracted on study and patient characteristics, all-cause and OAB-specific direct costs, resource use, and indirect costs...
January 13, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29327120/readmission-and-reoperation-after-midurethral-sling
#18
Erik D Hokenstad, Amy E Glasgow, Elizabeth B Habermann, John A Occhino
INTRODUCTION AND HYPOTHESIS: We aimed to determine the rate of readmission and reoperation for patients undergoing midurethral sling (MUS) placement for stress urinary incontinence (SUI). METHODS: The American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database was queried to identify all isolated MUS placed from 2012 through 2015 using the Current Procedural Terminology 4 (CPT-4) code for MUS with or without cystoscopy (57,288 ± 52,000)...
January 11, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29326206/whole-genome-draft-sequences-of-nine-asymptomatic-escherichia-coli-bacteriuria-isolates-from-diabetic-patients
#19
Christoph Stork, Beáta Kovács, Eva Trost, Tamás Kovács, György Schneider, Barnabás Rózsai, Monika Kerényi, Levente Emődy, Ulrich Dobrindt
Escherichia coli can colonize the urinary bladder without causing a disease response in the host. This asymptomatic bacteriuria (ABU) can protect against recurrent symptomatic urinary tract infection by virulent bacteria. Here, we report the whole-genome sequences of nine E. coli ABU isolates from diabetic patients.
January 11, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29326004/health-care-associated-infections-in-iran-a-national-update-for-the-year-2015
#20
Babak Eshrati, Hossein Masoumi Asl, Shirin Afhami, Zahra Pezeshki, Arash Seifi
BACKGROUND: A national surveillance system for health care-associated infections (HAIs) in Iran is relatively new, and an update on incidence and mortality rates can aid clinicians and stakeholders in development of new guidelines and imperative modifications to be made. METHODS: Data were extracted from the national HAIs surveillance software for more than 7 million hospitalizations during 2015. Data regarding age, gender, deaths, ward of admission, and microbiologic findings were collected and analyzed...
January 9, 2018: American Journal of Infection Control
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