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Upper airway cough syndrome

Christine L Vigeland, Andrew H Hughes, Maureen R Horton
Idiopathic pulmonary fibrosis (IPF) is a progressive disease of dysregulated wound healing leading to unremitting scarring and loss of lung function. The predominant symptoms are dyspnea on exertion and a persistent dry cough. For patients with IPF, cough is more than just bothersome; it has a significant negative impact on quality of life and is a marker of disease severity and progression. The etiology of cough in IPF is unclear but may be due to architectural distortion of the lungs, increased sensitivity of the cough reflex, airway inflammation, or changes in mucus production and clearance...
February 2017: Respiratory Medicine
Guiyuan Jiang, Xinying Huang, Tianlin Li, Dongping Xu
BACKGROUND/AIM: To investigate the clinical features and underlying etiologies of chronic cough (CC). MATERIALS AND METHODS: Five hundred and ten CC patients were enrolled. The phases, characteristics and associated clinical manifestations of CC among the gastroesophageal reflux cough (GERC), cough-variant asthma (CVA), and upper airway cough syndrome (UACS) groups were compared, and the diagnostic values of each group were evaluated by multiple regression analysis...
December 20, 2016: Turkish Journal of Medical Sciences
Louis-Philippe Boulet, Julie Turmel, Richard S Irwin
BACKGROUND: Cough is a common symptom experienced by athletes, particularly after exercise. We performed a systematic review to assess the following in this population: (1) the main causes of acute and recurrent cough, either exercise-induced or not, (2) how cough is assessed, and (3) how cough is treated in this population. From the systematic review, suggestions for management were developed. METHODS: This review was performed according to the CHEST methodological guidelines and Grading of Recommendations Assessment, Development and Evaluation framework until April 2015...
February 2017: Chest
Hyeon-Kyoung Koo, Ina Jeong, Sei Won Lee, Jinkyeong Park, Joo-Hee Kim, So Young Park, Hye Yun Park, Chin Kook Rhee, Yee Hyung Kim, Ji Ye Jung, Sung-Kyoung Kim, Yong Hyun Kim, Eun Young Choi, Ji-Yong Moon, Jong-Wook Shin, Jin Woo Kim, Kyung Hoon Min, Sei Won Kim, Kwang Ha Yoo, Je Hyeong Kim, Seung Hun Jang, Hyoung Kyu Yoon, Hui Jung Kim, Ki-Suck Jung, Deog Kyeom Kim
Although chronic cough is very common, its prevalence and causes have been rarely reported in the large general population including smokers. This study aimed to identify the prevalence of possible causes of chronic cough and their clinical impact.From Korean National Health and Nutrition Examination Survey (KNHANES) data including 119,280 adults aged over 40 years, 302 individuals with chronic cough were recruited irrespective of smoking status. Data from questionnaire, laboratory tests including spirometry, chest radiographs, and otorhinolaryngologic examination were analyzed...
September 2016: Medicine (Baltimore)
Whittney A Warren, Scott S Dalane, Bryce D Warren, Paul G Peterson, Rodney D Boyum, William Kelly
A 64-year-old male former smoker with a history of prostate cancer presented to our pulmonary clinic, complaining of nonproductive cough for 10 years. Prior evaluation included treatment for upper airway cough syndrome and gastroesophageal reflux, stopping angiotensin-converting enzyme inhibitor, and initiation of inhaled β-agonists. Esophageal pH monitoring indicated silent reflux, and proton pump inhibitor therapy was started. He continued to cough and complain of dyspnea. Physical examination produced unremarkable results, with no evidence of lymphadenopathy...
September 2016: Chest
Pelin Özdemir, Münevver Erdinç, Rukiye Vardar, Ali Veral, Serdar Akyıldız, Özer Özdemir, Serhat Bor
Background/Aims: Gastroesophageal reflux disease (GERD) is one of the main causes of chronic cough. We evaluated the role of microaspiration in the pathogenesis of reflux-related cough by determining the amount of lipid-laden macrophages (LLMs) in bronchoalveolar lavage (BAL) specimens. Methods: A total of 161 cases of chronic cough were evaluated, and 36 patients (average age 48.2 years) were recruited for this single center prospective study. Patients with a history of smoking, angiotensin converting enzyme inhibitor usage, any abnormality on pulmonary function tests, abnormal chest X-rays, occupational or environmental exposures, or upper airway cough syndrome were excluded...
January 30, 2017: Journal of Neurogastroenterology and Motility
Andreas Achilleos
Chronic cough is common and has a significant impact on the wellbeing of patients and the use and cost of health care services. Traditionally the approach to chronic cough in patients who are nonsmokers and are not taking an angiotensin-converting enzyme inhibitor has focused on the diagnosis and management of the upper airway cough syndrome, asthma, and reflux disease. The evaluation of patients with chronic cough frequently involves trials of empiric therapy for these 3 conditions. Chronic cough may be perpetuated by abnormalities of the cough reflex and sensitization of its afferent and central components...
September 2016: Medical Clinics of North America
Hongli Jiang, Wei Liu, Guanhong Li, Tao Fan, Bing Mao
Context • Upper airway cough syndrome (UACS), previously called postnasal drip syndrome (PNDS), has been considered universally to be one of the most common causes of chronic cough. As an important part of complementary and alternative therapy, traditional Chinese medicine (TCM) has found an exact curative therapy for chronic cough through clinical practice for thousands of years. Objective • The aim of the current review was to investigate systematically the beneficial and adverse effects of Chinese medicinal herbs (CMH) in the treatment of UACS...
March 2016: Alternative Therapies in Health and Medicine
W Y Liu, Q Yu, H M Yue, J B Zhang, L Li, X Y Wang, J M Hu, T Feng, J Y Pu, X Bai
OBJECTIVE: To explore the distribution characteristics of etiology and clinical feature of chronic cough in Lanzhou. METHODS: Based on the guidelines of the diagnostic process of chronic cough in China, data of medical history and physical examinations were collected, and chest X-ray, pulmonary function plus airway hyperresponsiveness, induced sputum eosinophils, sinus X-ray or CT, 24 h esophageal pH monitoring, chest high-resolution CT and bronchoscopy were performed accordingly for outpatients with chronic cough...
May 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
Kefang Lai, Ling Lin, Baojuan Liu, Ruchong Chen, Yan Tang, Wei Luo, Qiaoli Chen
BACKGROUND AND OBJECTIVE: Patients presenting with refractory postinfectious cough may respond to glucocorticosteroids but it is unclear whether airway eosinophilic inflammation exists in those patients. We aimed to determine the airway inflammation and causes of subacute cough following acute upper respiratory tract infection (AURTI). METHODS: One hundred and sixteen patients with persistent cough lasting 3-8 weeks after upper respiratory tract infection were evaluated with differential cell count in induced sputum, spirometry and methacholine bronchial challenge testing...
May 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
Chin Kook Rhee, Ji Ye Jung, Sei Won Lee, Joo-Hee Kim, So Young Park, Kwang Ha Yoo, Dong Ah Park, Hyeon-Kyoung Koo, Yee Hyung Kim, Ina Jeong, Je Hyeong Kim, Deog Kyeom Kim, Sung-Kyoung Kim, Yong Hyun Kim, Jinkyeong Park, Eun Young Choi, Ki-Suck Jung, Hui Jung Kim
Cough is one of the most common symptom of many respiratory diseases. The Korean Academy of Tuberculosis and Respiratory Diseases organized cough guideline committee and cough guideline was developed by this committee. The purpose of this guideline is to help clinicians to diagnose correctly and treat efficiently patients with cough. In this article, we have stated recommendation and summary of Korean cough guideline. We also provided algorithm for acute, subacute, and chronic cough. For chronic cough, upper airway cough syndrome (UACS), cough variant asthma (CVA), and gastroesophageal reflux disease (GERD) should be considered...
January 2016: Tuberculosis and Respiratory Diseases
Yuting Jin, Xing Chen, Jinrong Wang, Chunyan Guo, Lifeng Sun
OBJECTIVE: To analyze the clinical characteristic of Kartagener syndrome in Chinese and foreign children. METHOD: Four cases of Kartagener syndrome diagnosed in our hospital were analyzed with literature review. The differences between Chinese and foreign children in clinical manifestations and diagnosis were compared. RESULT: All of the cases had the following clinical manifestations: recurrent productive cough, nasosinusitis, dextrocardia, total situs inversus and bronchiectasia...
November 2015: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
G Draiss, K Razzouki, Y Mouaffak, M Bouskraoui, S Younous
This paper presents the case of a 12-year-old child who presented with an 8-day history of cough, respiratory distress, and hemoptysis. He was admitted first to the pediatric intensive care unit to reestablish hemodynamic and respiratory stability. The chest X-ray showed a bilateral alveolar-interstitial syndrome. Four hours after admission, he had a coughing fit, moderately abundant hemoptysis, and a leech appeared in his mouth, which was removed by the mother. Symptoms completely disappeared afterwards. Endoscopy and ear-throat-laryngeal examination done thereafter were normal...
January 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Akio Niimi, Kian Fan Chung
Chronic cough is a very common symptom for which patients seek medical attention but can often be difficult to manage, because associated causes may remain elusive and treatment of any associated causes does not always provide adequate relief. Current antitussives have limited efficacy and undesirable side-effects. Patients with chronic cough typically describe sensory symptoms suggestive of upper airway and laryngeal neural dysfunction. They often report cough triggered by low-level physical and chemical stimuli supporting the recently emerging concept of 'cough hypersensitivity syndrome'...
December 2015: Pulmonary Pharmacology & Therapeutics
Haiyan Zhu, Xingmei Yu, Chuangli Hao, Yuqing Wang, Xiaoyun Yang, Yanhong Lu, Huiquan Sun, Wei Luo, Kefang Lai
OBJECTIVE: To determine the diagnostic value of fractional exhaled nitric oxide (FeNO) measurement in diagnosis of Cough Variant Asthma (CVA) in children. METHODS: Outpatients with a cough > 4 weeks visiting The Children's Hospital Affiliated to Suzhou University from March 2012 to April 2013 were enrolled. FeNO was measured by a nitric oxide analyzer in accordance with American Thoracic Society guidelines. The levels of FeNO in CVA and other causes of chronic cough were compared...
May 2015: Chinese Journal of Tuberculosis and Respiratory Diseases
Ahmet Hakan Gedik, Erkan Cakir, Emel Torun, Aysegul Dogan Demir, Mehmet Kucukkoc, Ufuk Erenberk, Selcuk Uzuner, Mustafa Nursoy, Emin Ozkaya, Fadlullah Aksoy, Selim Gokce, Kayhan Bahali
BACKGROUND: This study aims to evaluate the children with chronic cough and to analyze their etiological factors according to the age groups. METHOD: Five hundred sixty-three children with chronic cough were included. The last diagnosis were established and were also emphasized according to the age groups. RESULTS: The mean age was 5.4 ± 3.8 years (2-months-17-years) and 52 % of them were male. The most common final diagnosis from all the participants were: asthma (24...
2015: Italian Journal of Pediatrics
Kian Fan Chung, Brendan Canning, Lorcan McGarvey
At the Eighth International London Cough Conference held in London in July 2014, the focus was on the relatively novel concept of cough hypersensitivity syndrome (CHS) as forming the basis of chronic cough. This concept has been formulated following understanding of the neuronal pathways for cough and a realisation that not all chronic cough is usually associated with a cause. The CHS is defined by troublesome coughing triggered by low level of thermal, mechanical or chemical exposure. It also encompasses other symptoms or sensations such as laryngeal hypersensitivity, nasal hypersensitivity and possibly also symptoms related to gastrooesopahgeal reflux...
December 2015: Pulmonary Pharmacology & Therapeutics
M Dąbrowska, E M Grabczak, M Arcimowicz, A Domeracka-Kołodziej, J Domagała-Kulawik, R Krenke, M Maskey-Warzęchowska, B Tarchalska, R Chazan
Chronic cough is a common medical problem. The aim of the study was to analyze chronic cough causes in non-smoking patients and to search for demographic factors associated with different cough reasons. The etiology of cough was determined by medical history, diagnostic tests and response to specific treatment. Patients with significant abnormalities in the chest radiograph or spirometry were not included. The study included 131 non-smoking patients; median age 54 years, 77 % female. The most frequent causes of cough were gastroesophageal reflux disease (GERD) (62 %) and upper airway cough syndrome (UACS) (46 %)...
2015: Advances in Experimental Medicine and Biology
Mauro Maniscalco, Stanislao Faraone, Matteo Sofia, Antonio Molino, Alessandro Vatrella, Anna Zedda
INTRODUCTION: Chronic cough is usually defined as a cough that lasts for eight weeks or longer. Its etiological diagnosis is not always straightforward, and the measurement of exhaled nitric oxide (FeNO) has been proposed in patients' evaluation. No studies have assessed the usefulness of extended exhaled NO measurement for the evaluation of chronic cough. Therefore, we aimed at evaluating the usefulness of an extended exhaled NO measurement and nasal NO for an initial evaluation of chronic cough...
August 2015: Respiratory Medicine
Jennifer A Anderson
PURPOSE OF REVIEW: The purpose of this study is to review the relevant literature concerning work-associated irritable larynx syndrome (WILS), a hyperkinetic laryngeal disorder associated with occupational irritant exposure. Clinical symptoms are variable and include dysphonia, cough, dyspnoea and globus pharyngeus. WILS is a clinical diagnosis and can be difficult to differentiate from asthma. Treatment options for WILS include medical and behavioural therapy. RECENT FINDINGS: Laryngeal-centred upper airway symptoms secondary to airborne irritants have been documented in the literature under a variety of diagnostic labels, including WILS, vocal cord dysfunction (VCD), laryngeal hypersensitivity and laryngeal neuropathy and many others...
April 2015: Current Opinion in Allergy and Clinical Immunology
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