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https://www.readbyqxmd.com/read/28209661/non-topical-management-of-recalcitrant-paediatric-atopic-dermatitis
#1
REVIEW
Jin Ho Chong, Mark Jean Aan Koh
Atopic dermatitis (AD) is a common chronic, pruritic skin disease in children. As the incidence of AD increases, especially in high-income countries, paediatricians may see an increasing number of recalcitrant AD cases in their practice. Although these cases are principally managed by paediatric dermatologists, it is important for paediatricians to be aware of the use and side effects of non-topical treatment like phototherapy and systemic agents as well as the evidence for alternative treatment, which caregivers may ask about...
February 16, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28187880/-management-and-prevention-of-cow-s-milk-protein-allergy-contribution-of-community-pharmacists
#2
C Rouelle, A Arion, V Prevost
Cow's milk protein allergy (CMPA) is a public health issue in children whose quality of life is strongly affected. The objective of this article is to review the present state of knowledge on the CMPA, and highlight some emerging alternatives in its management and in its prevention. Good knowledge in the appropriate infant formula, exclusion diets, the handling of the emergency treatment thanks to the use of epinephrine auto-injector pens, the use of personalized care project and accessibility to allergic patients' association are factors that secure the management...
February 7, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/28155088/the-enigmatic-gut-in-cystic-fibrosis-linking-inflammation-dysbiosis-and-the-increased-risk-of-malignancy
#3
REVIEW
Millie Garg, Chee Y Ooi
PURPOSE OF REVIEW: Intestinal inflammation, dysbiosis, and increased gastrointestinal malignancy risks are well-described in patients with cystic fibrosis (CF). However, there is limited understanding of their pathophysiology. This review aims to discuss these issues and assess potential links between them. RECENT FINDINGS: Evidence of links between intestinal inflammation and dysbiosis (an imbalance in intestinal microbial populations) exist. Recent studies have demonstrated reduction in intestinal inflammation with probiotic administration...
February 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28131521/espen-guideline-clinical-nutrition-in-inflammatory-bowel-disease
#4
Alastair Forbes, Johanna Escher, Xavier Hébuterne, Stanisław Kłęk, Zeljko Krznaric, Stéphane Schneider, Raanan Shamir, Kalina Stardelova, Nicolette Wierdsma, Anthony E Wiskin, Stephan C Bischoff
INTRODUCTION: The ESPEN guideline presents a multidisciplinary focus on clinical nutrition in inflammatory bowel disease (IBD). METHODOLOGY: The guideline is based on extensive systematic review of the literature, but relies on expert opinion when objective data were lacking or inconclusive. The conclusions and 64 recommendations have been subject to full peer review and a Delphi process in which uniformly positive responses (agree or strongly agree) were required...
December 31, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28114246/safety-of-bifidobacterium-animalis-subsp-lactis-b-lactis-strain-bb-12-supplemented-yogurt-in-healthy-children
#5
Tina P Tan, Zhaoyong Ba, Mary E Sanders, Frank J D'Amico, Robert F Roberts, Keisha H Smith, Daniel J Merenstein
OBJECTIVES: Probiotics are live microorganisms that may provide health benefits to the individual when consumed in sufficient quantities. For studies conducted on health or disease endpoints on probiotics in the United States, the Food and Administration has required those studies to be conducted as investigational new drugs. This phase I, double-blinded, randomized, controlled safety study represents the first requirement of this pathway. The purpose of the study was to determine the safety of Bifidobacterium animalis subsp...
February 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28108106/do-children-just-grow-out-of-irritable-bowel-syndrome
#6
Eleonora Giannetti, Marco Maglione, Elisa Sciorio, Vincenzo Coppola, Erasmo Miele, Annamaria Staiano
OBJECTIVE: Few data exist on natural history of irritable bowel syndrome (IBS) in children; therefore we investigated symptoms evolution over time in a cohort of children with IBS. STUDY DESIGN: In this observational, single-center study, we prospectively enrolled newly diagnosed children with IBS and reassessed them after 24 months. At both time points, patients completed a symptoms questionnaire, and a score of stool consistency was obtained. The therapeutic strategy adopted was also recorded...
January 18, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28107866/potential-of-zimbabwean-commercial-probiotic-products-and-strains-of-lactobacillus-plantarum-as-prophylaxis-and-therapy-against-diarrhoea-caused-by-escherichia-coli-in-children
#7
Walter Chingwaru, Jerneja Vidmar
OBJECTIVE: To evaluate the potential of commercial fermented products sold in the country, and strains of Lactobacillus plantarum (L. plantarum) as prophylaxis and therapy against diarrhoea in children. METHODS: The antimicrobial potential of cultures of lactobacilli enriched from 4 Zimbabwean commercial food/beverage products: Dairibord Lacto sour milk (DLSM), Probrand sour milk (PSM), Kefalos Vuka cheese (KVC) and Chibuku opaque beer (COB); and four strains of L...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28104319/the-mexican-consensus-on-probiotics-in-gastroenterology
#8
M A Valdovinos, E Montijo, A T Abreu, S Heller, A González-Garay, D Bacarreza, M Bielsa-Fernández, M C Bojórquez-Ramos, F Bosques-Padilla, A I Burguete-García, R Carmona-Sánchez, A Consuelo-Sánchez, E Coss-Adame, J A Chávez-Barrera, M de Ariño, J Flores-Calderón, O Gómez-Escudero, M S González-Huezo, M E Icaza-Chávez, A Larrosa-Haro, M Morales-Arámbula, C Murata, J A Ramírez-Mayans, J M Remes-Troche, T Rizo-Robles, M Peláez-Luna, E M Toro-Monjaraz, A Torre, M E Urquidi-Rivera, R Vázquez, J K Yamamoto-Furusho, F Guarner
INTRODUCTION: Probiotics are frequently prescribed in clinical practice. Their efficacy in treating gastrointestinal disorders is supported by a significant number of clinical trials. However, the correct prescription of these agents is hampered due to a lack of knowledge of the scientific evidence and to the different presentations and microbial compositions of the probiotics that are currently available. AIM: To provide the clinician with a consensus review of probiotics and recommendations for their use in gastroenterology...
January 16, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28100322/-association-between-risk-factors-during-maternal-pregnancy-and-the-neonatal-period-and-childhood-bronchial-asthma
#9
Hui-Qin Zhang, Rui Fan, Jing-Jing Zhang, Xiao-Juan Tao, Xin Sun
OBJECTIVE: To study the association of the risk factors during maternal pregnancy and the neonatal period with childhood bronchial asthma. METHODS: A total of 306 children with asthma (asthma group) and 250 healthy children (control group) were enrolled. Their clinical data during the neonatal period and the maternal data during pregnancy were retrospectively studied. RESULTS: The univariate analysis showed that there were significant differences in the rates of maternal use of antibiotics during pregnancy, use of antibiotics and probiotics during the neonatal period, preterm birth, cesarean section, low birth weight, and breast feeding (>6 months) between the asthma and control groups (P<0...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28087866/when-can-infants-and-children-benefit-from-probiotics
#10
Paul Dassow, Steven Fox
The latest studies indicate that probiotics can help with colic, eczema, and certain types of diarrhea. They may also help with upper respiratory infections and IBS pain.
November 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/28079729/effect-of-probiotics-on-diarrhea-in-children-with-severe-acute-malnutrition-a-randomized-controlled-study-in-uganda
#11
Benedikte Grenov, Hanifa Namusoke, Betty Lanyero, Nicolette Nabukeera-Barungi, Christian Ritz, Christian Mølgaard, Henrik Friis, Kim F Michaelsen
OBJECTIVES: To assess the effect of probiotics on diarrhea during in- and outpatient treatment of children with severe acute malnutrition (SAM). METHODS: A randomized, double-blind, placebo-controlled study was conducted involving 400 children admitted with SAM. Patients received one daily dose of a blend of Bifidobacterium animalis subsp. lactis (BB-12) and Lactobacillus rhamnosus (LGG) (10 billion colony-forming units, 50:50) or placebo during hospitalization followed by an 8-12 week outpatient treatment period, depending on patients' recovery rate...
January 11, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28067304/weissella-cibaria-wikim28-ameliorates-atopic-dermatitis-like-skin-lesions-by-inducing-tolerogenic-dendritic-cells-and-regulatory-t-cells-in-balb-c-mice
#12
Seul Ki Lim, Min-Sung Kwon, Jieun Lee, Young Joon Oh, Ja-Young Jang, Jong-Hee Lee, Hae Woong Park, Young-Do Nam, Myung-Ji Seo, Seong Woon Roh, Hak-Jong Choi
The occurrence of atopic dermatitis (AD), a chronic inflammatory skin disease, has been increasing steadily in children and adults in recent decades. In this study, we evaluated the ability of the lactic acid bacterium Weissella cibaria WIKIM28 isolated from gatkimchi, a Korean fermented vegetable preparation made from mustard leaves, to suppress the development of AD induced by 2,4-dinitrochlorobenzene in a murine model. Oral administration of W. cibaria WIKIM28 reduced AD-like skin lesions, epidermal thickening, and serum immunoglobulin E levels...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28064261/clinical-effects-of-prebiotics-in-pediatric-population
#13
Rok Orel, Lea Vodušek Reberšak
CONTEXT: Prebiotics are non-digestible components of food that in a selective manner trigger the expansion of microbes in the gut with valuable effects for the health of the host. In our document, current literature pertaining to the clinical effects of the use of prebiotics for the treatment and prevention of some common pediatric pathology such as infantile colic, constipation, absorption of minerals, weight gain, diarrhea, respiratory infections, and eczema is reviewed. EVIDENCE: Data was collected through search of the MEDLINE, PubMed, UpToDate, Cochrane Database of Systemic Reviews, and the Cochrane Controlled Trials Register database as well as through references from relevant articles, all until September 2015...
December 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/28057659/lactobacillus-reuteri-dsm-17938-in-the-prevention-of-antibiotic-associated-diarrhoea-in-children-protocol-of-a-randomised-controlled-trial
#14
Maciej Kołodziej, Hania Szajewska
INTRODUCTION: Administration of some probiotics appears to reduce the risk of antibiotic-associated diarrhoea (AAD). The effects of probiotics are strain-specific, thus, the efficacy and safety of each probiotic strain should be established separately. We aim to assess the effects of Lactobacillus reuteri DSM 17938 administration for the prevention of diarrhoea and AAD in children. METHODS AND ANALYSIS: A total of 250 children younger than 18 years treated with antibiotics will be enrolled in a double-blind, randomised, placebo-controlled trial in which they will additionally receive L...
January 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28052594/network-meta-analysis-of-probiotics-to-prevent-respiratory-infections-in-children-and-adolescents
#15
REVIEW
Marina Azambuja Amaral, Gabriela Helena Barbosa Ferreira Guedes, Matias Epifanio, Mario Bernardes Wagner, Marcus Herbert Jones, Rita Mattiello
Probiotics have emerged as a promising intervention for the prevention of respiratory tract infections (RTIs) in children. Assess the effect of probiotics on prevention of RTIs in children and adolescents. MEDLINE, EMBASE, LILACS, SCIELO, CINAHL, SCOPUS, and Web of Science. Key words: "respiratory tract infections" AND probiotics. Randomized controlled trials RCT assessing the effect of probiotics on RTIs in children and adolescents were included. Two reviewers, working independently, to identify studies that met the eligibility criteria...
January 3, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28043872/extensively-hydrolyzed-casein-formula-containing-lactobacillus-rhamnosus-gg-reduces-the-occurrence-of-other-allergic-manifestations-in-children-with-cow-s-milk-allergy-3-year-randomized-controlled-trial
#16
Roberto Berni Canani, Margherita Di Costanzo, Giorgio Bedogni, Antonio Amoroso, Linda Cosenza, Carmen Di Scala, Viviana Granata, Rita Nocerino
BACKGROUND: Children with cow's milk allergy (CMA) have an increased risk of other allergic manifestations (AMs). OBJECTIVE: We performed a parallel-arm randomized controlled trial to test whether administration of an extensively hydrolyzed casein formula (EHCF) containing the probiotic Lactobacillus rhamnosus GG (LGG) can reduce the occurrence of other AMs in children with CMA. METHODS: Children with IgE-mediated CMA were randomly allocated to the EHCF or EHCF+LGG groups and followed for 36 months...
December 30, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28028357/can-probiotics-benefit-children-with-autism-spectrum-disorders
#17
REVIEW
Fernando Navarro, Yuying Liu, Jon Marc Rhoads
Children with autism are commonly affected by gastrointestinal problems such as abdominal pain, constipation and diarrhea. In recent years, there has been a growing interest in the use of probiotics in this population, as it hypothetically may help to improve bowel habits and the behavioral and social functioning of these individuals. The gut microbiome plays an important role in the pathophysiology of organic as well as functional gastrointestinal disorders. Microbial modification with the use of antibiotics, probiotics, and fecal transplantation have been effective in the treatment of conditions such as recurrent Clostridium difficile infection, pouchitis, and irritable bowel syndrome...
December 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28008787/a-review-of-dose-responses-of-probiotics-in-human-studies
#18
A C Ouwehand
The probiotic definition requires the administration of an 'adequate amount' in order to obtain a health benefit. What that amount should be is not indicated. Here, an overview is given of studies that investigated the dose-response relation of probiotics in human interventions. Studies were divided in; meta-analyses, meta-analyses on specific probiotic strains, and studies testing two or more doses of a probiotic (combination) in the same study. Meta-analyses on the effect of probiotics on antibiotic associated diarrhoea (AAD) suggest a dose-response effect; for Clostridium difficile-associated diarrhoea on the other hand no dose-response was observed...
December 23, 2016: Beneficial Microbes
https://www.readbyqxmd.com/read/27996291/is-the-prevalence-of-atopic-dermatitis-in-korean-children-decreasing-analysis-of-the-national-statistics-data-2009-2014
#19
Ji Young Lee, Hea-Kyoung Yang, Minji Kim, Jihyun Kim, Kangmo Ahn
BACKGROUND: The prevalence of atopic dermatitis (AD) in children is increasing in many developing countries. OBJECTIVE: This study aimed to explore trends in the prevalence of AD in Korean children. METHODS: We analyzed data from the Korean National Health Insurance Service from 2009 to 2014. Data for the estimated populations were collected from the Statistics Korea. The annual prevalence of AD was obtained by dividing the number of patients by the estimated population each year...
December 12, 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/27994593/intestinal-innate-antiviral-immunity-and-immunobiotics-beneficial-effects-against-rotavirus-infection
#20
REVIEW
Julio Villena, Maria Guadalupe Vizoso-Pinto, Haruki Kitazawa
The mucosal tissues of the gastrointestinal tract are the main portal entry of pathogens such as rotavirus (RV), which is a leading cause of death due to diarrhea among young children across the globe and a major cause of severe acute intestinal infection in livestock animals. The interactions between intestinal epithelial cells (IECs) and immune cells with RVs have been studied for several years, and now, it is known that the innate immune responses triggered by this virus can have both beneficial and detrimental effects for the host...
2016: Frontiers in Immunology
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