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Children and probiotics

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https://www.readbyqxmd.com/read/28813007/the-efficacy-of-bifidobacterium-longum-bori-and-lactobacillus-acidophilus-ad031-probiotic-treatment-in-infants-with-rotavirus-infection
#1
Myeong Soo Park, Bin Kwon, Seockmo Ku, Geun Eog Ji
A total of 57 infants hospitalized with rotavirus disease were included in this study. The children were randomly divided into the study's two treatment groups: three days of the oral administration of (i) a probiotics formula containing both Bifidobacterium longum BORI and Lactobacillus acidophilus AD031 (N = 28); or (ii) a placebo (probiotic-free skim milk, N = 29) and the standard therapy for diarrhea. There were no differences in age, sex, or blood characteristics between the two groups. When the 57 cases completed the protocol, the duration of the patients' diarrhea was significantly shorter in the probiotics group (4...
August 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28795659/role-of-mycotoxins-in-the-pathobiology-of-autism-a-first-evidence
#2
Barbara De Santis, Carlo Brera, Alessandra Mezzelani, Sabina Soricelli, Francesca Ciceri, Giorgio Moretti, Francesca Debegnach, Maria Clara Bonaglia, Laura Villa, Massimo Molteni, Maria Elisabetta Raggi
OBJECTIVES: Gene-environment interaction is an emerging hypothesis to expound not only the autism pathogenesis but also the increased incidence of neurodevelopmental disorders (such as autistic spectrum disorder, attention-deficit, hyperactivity disorder). Among xenobiotics, mycotoxins are worldwide contaminants of food that provoke toxicological effects, crucially resembling several symptoms associated with autism such as oxidative stress, intestinal permeability, and inflammation. Here, we focused on a group of mycotoxins to test their role in the manifestation of autism, try to explain their mechanism of action, and discuss possible preventive and therapeutic interventions...
August 10, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28795339/impact-of-nasopharyngeal-microbiota-on-the-development-of-respiratory-tract-diseases
#3
REVIEW
S Esposito, N Principi
Knowledge of whether and how respiratory microbiota composition can prime the immune system and provide colonisation resistance, limiting consecutive pathobiont overgrowth and infections, is essential to improving the prevention and therapy of respiratory disorders. Modulation of dysbiotic ecosystems or reconstitution of missing microbes might be a possible measure to reduce respiratory diseases. The aim of this review is to analyse the role of nasopharyngeal microbiota in the development of respiratory tract disease in paediatric-age subjects...
August 9, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28792444/role-of-microbial-modulation-in-management-of-atopic-dermatitis-in-children
#4
REVIEW
Lies Hulshof, Belinda Van't Land, Aline B Sprikkelman, Johan Garssen
The pathophysiology of atopic dermatitis (AD) is multifactorial and is a complex interrelationship between skin barrier, genetic predisposition, immunologic development, skin microbiome, environmental, nutritional, pharmacological, and psychological factors. Several microbial modulations of the intestinal microbiome with pre- and/or probiotics have been used in AD management, with different clinical out-come (both positive, as well as null findings). This review provides an overview of the clinical evidence from trials in children from 2008 to 2017, aiming to evaluate the effect of dietary interventions with pre- and/or pro-biotics for the treatment of AD...
August 9, 2017: Nutrients
https://www.readbyqxmd.com/read/28790133/detection-of-acute-gastroenteritis-etiology-in-hospitalized-young-children-associated-factors-and-outcomes
#5
Jamie M Pinto, Anna Petrova
BACKGROUND: The decision to test for the etiology of diarrhea is a challenging question for practicing pediatricians. METHODS: The main goal of this retrospective cohort study was to identify factors associated with testing for and diagnosis of rotavirus, Clostridium difficile, or other bacterial infections, as well as the length of stay (LOS) for children with acute gastroenteritis who were hospitalized at a single institution. Patients aged 6 to 60 months with acute diarrhea (<14 days) and no underlying gastrointestinal conditions were included...
August 8, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28767339/assessing-gut-microbiota-perturbations-during-the-early-phase-of-infectious-diarrhea-in-vietnamese-children
#6
Hao Chung The, Paola Florez de Sessions, Song Jie, Duy Pham Thanh, Corinne N Thompson, Chau Nguyen Ngoc Minh, Collins Wenhan Chu, Tuan-Anh Tran, Nicholas R Thomson, Guy E Thwaites, Maia A Rabaa, Martin Hibberd, Stephen Baker
Diarrheal diseases remain the second most common cause of mortality in young children in developing countries. Efforts have been made to explore the impact of diarrhea on bacterial communities in the human gut, but a thorough understanding has been impeded by inadequate resolution in bacterial identification and the examination of only few etiological agents. Here, by profiling an extended region of the 16S rRNA gene in the fecal microbiome, we aimed to elucidate the nature of gut microbiome perturbations during the early phase of infectious diarrhea caused by various etiological agents in Vietnamese children...
August 2, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28767077/gut-liver-axis-derangement-in-non-alcoholic-fatty-liver-disease
#7
REVIEW
Marco Poeta, Luca Pierri, Pietro Vajro
Non-alcoholic fatty liver disease (NAFLD) is the most frequent type of chronic liver disease in the pediatric age group, paralleling an obesity pandemic. A "multiple-hit" hypothesis has been invoked to explain its pathogenesis. The "first hit" is liver lipid accumulation in obese children with insulin resistance. In the absence of significant lifestyle modifications leading to weight loss and increased physical activity, other factors may act as "second hits" implicated in liver damage progression leading to more severe forms of inflammation and hepatic fibrosis...
August 2, 2017: Children
https://www.readbyqxmd.com/read/28762696/probiotics-for-gastrointestinal-conditions-a-summary-of-the-evidence
#8
REVIEW
Thad Wilkins, Jacqueline Sequoia
Probiotics contain microorganisms, most of which are bacteria similar to the beneficial bacteria that occur naturally in the human gut. Probiotics have been widely studied in a variety of gastrointestinal diseases. The most-studied species include Lactobacillus, Bifidobacterium, and Saccharomyces. However, a lack of clear guidelines on when to use probiotics and the most effective probiotic for different gastrointestinal conditions may be confusing for family physicians and their patients. Probiotics have an important role in the maintenance of immunologic equilibrium in the gastrointestinal tract through the direct interaction with immune cells...
August 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28762070/systematic-review-probiotics-for-functional-constipation-in-children
#9
REVIEW
Katarzyna Wojtyniak, Hania Szajewska
We updated our 2010 systematic review on the efficacy of probiotics in the treatment of constipation in children. The MEDLINE, EMBASE, and Cochrane Library databases; clinical trial registries; and reference lists of included studies were searched to February 2017 for randomized controlled trials (RCTs) performed in children, with no language restriction. The primary outcome measure was treatment success, as defined by the investigators. We included seven RCTs with a total of 515 participants. Included trials were heterogeneous with respect to study population, probiotic strains, dosages, study duration, and follow-up...
August 1, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28733284/specific-signatures-of-the-gut-microbiota-and-increased-levels-of-butyrate-in-children-treated-with-fermented-cow-s-milk-containing-heat-killed-lactobacillus-paracasei-cba-l74
#10
Roberto Berni Canani, Francesca De Filippis, Rita Nocerino, Manolo Laiola, Lorella Paparo, Antonio Calignano, Carmen De Caro, Lorena Coretti, Lorenzo Chiariotti, Jack A Gilbert, Danilo Ercolini
We recently demonstrated that cow's milk fermented with the probiotic L.paracasei CBA L74 (FM-CBAL74) reduces the incidence of respiratory and gastrointestinal tract infections in young children attending school. This effect apparently derives from a complex regulation of non-immune and immune protective mechanisms. We investigated wheter FM-CBAL74 could regulate gut microbiota composition and butyrate production.We randomly selected 20 healthy children (12-48 months) from the previous randomized controlled trial, before (t0) and after 3 months (t3) of dietary treatment with FM-CBAL74 (FM), or placebo (PL)...
July 21, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28727206/the-mother-offspring-dyad-microbial-transmission-immune-interactions-and-allergy-development
#11
REVIEW
Maria C Jenmalm
The increasing prevalence of allergy in affluent countries may be caused by reduced intensity and diversity of microbial stimulation, resulting in abnormal postnatal immune maturation. Most studies investigating the underlying immunomodulatory mechanisms have focused on postnatal microbial exposure, for example demonstrating that the gut microbiota differs in composition and diversity during the first months of life in children who later do or do not develop allergic disease. However, it is also becoming increasingly evident that the maternal microbial environment during pregnancy is important in childhood immune programming, and the first microbial encounters may occur already in utero...
July 20, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28712129/lactobacillus-reuteri-dsm-17938-and-a-placebo-both-significantly-reduced-symptoms-in-children-with-functional-abdominal-pain
#12
M Maragkoudaki, G Chouliaras, R Orel, A Horvath, H Szajewska, A Papadopoulou
AIM: Lactobacillus reuteri is a Gram-positive bacterium that naturally inhabits the human intestinal tract. This study assessed how effectively the probiotic Lactobacilllus reuteri DSM 17938 managed childhood functional abdominal pain (FAP). METHODS: We recruited 54 children with a mean age 9.1±3.8 years, who were diagnosed with FAP in the outpatient clinics of three university hospitals in Greece, Slovenia and Poland, according to the Rome III criteria, from January 2013 to December 2015...
July 16, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28686541/the-role-of-probiotics-in-children-with-autism-spectrum-disorder-a-prospective-open-label-study
#13
Sanaa Y Shaaban, Yasmin G El Gendy, Nayra S Mehanna, Waled M El-Senousy, Howaida S A El-Feki, Khaled Saad, Osama M El-Asheer
OBJECTIVE: There are limited data on the efficacy of probiotics in children with ASD, therefore, this study aims to evaluate the efficacy and tolerability of probiotics in an Egyptian cohort of children with ASD. METHODS: Gastrointestinal (GI) flora were assessed by quantitative real-time PCR of stool samples of 30 autistic children from 5 to 9 years old. GI symptoms of autistic children were assessed with a modified six-item Gastrointestinal Severity Index (6-GSI) questionnaire, and autistic symptoms were assessed with Autism Treatment Evaluation Checklist (ATEC) before and after 3 months of supplementation of probiotics nutritional supplement formula (each gram contains 100 × 10(6) colony forming units of three probiotic strains; Lactobacillus acidophilus, Lactobacillus rhamnosus and Bifidobacteria longum)...
July 7, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28681177/efficacy-and-safety-of-probiotic-supplemented-triple-therapy-for-eradication-of-helicobacter-pylori-in-children-a-systematic-review-and-network-meta-analysis
#14
REVIEW
Jue-Rong Feng, Fan Wang, Xiao Qiu, Lynne V McFarland, Peng-Fei Chen, Rui Zhou, Jing Liu, Qiu Zhao, Jin Li
AIM: The aim of this study was to identify the best probiotic supplementation in triple therapy for pediatric population with Helicobacter pylori infection. METHODS: Eligible trials were identified by comprehensive searches. Relative risks with 95% confidence intervals and relative ranks with P scores were assessed. RESULTS: Twenty-nine trials (3122 participants) involving 17 probiotic regimens were identified. Compared with placebo, probiotic-supplemented triple therapy significantly increased H...
July 5, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28674113/probiotics-and-child-care-absence-due-to-infections-a-randomized-controlled-trial
#15
Rikke Pilmann Laursen, Anni Larnkjær, Christian Ritz, Hanne Hauger, Kim Fleischer Michaelsen, Christian Mølgaard
OBJECTIVES: The risk of infections is higher in children attending child care compared with children cared for at home. This study examined the effect of a combination of probiotics on absence from child care because of respiratory and gastrointestinal infections in healthy infants aged 8 to 14 months at the time of enrollment in child care. METHODS: The ProbiComp study was a randomized, double-blind, placebo-controlled study. A total of 290 infants were randomly allocated to receive a placebo or a combination of Bifidobacterium animalis subsp lactis and Lactobacillus rhamnosus in a dose of 10(9) colony-forming units of each daily for a 6-month intervention period...
August 2017: Pediatrics
https://www.readbyqxmd.com/read/28667722/randomized-controlled-trial-evaluating-probiotics-in-children-with-severe-acute-malnutrition-pediatric-gastroenterologist-s-viewpoint
#16
Rohan Malik
No abstract text is available yet for this article.
June 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28667721/randomized-controlled-trial-evaluating-probiotics-in-children-with-severe-acute-malnutrition-pediatrician-s-viewpoint
#17
Praveen Kumar
No abstract text is available yet for this article.
June 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28667720/randomized-controlled-trial-evaluating-probiotics-in-children-with-severe-acute-malnutrition-evidence-based-medicine-viewpoint
#18
J L Mathew
No abstract text is available yet for this article.
June 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28654019/preventive-effect-of-cow-s-milk-fermented-with-lactobacillus-paracasei-cba-l74-on-common-infectious-diseases-in-children-a-multicenter-randomized-controlled-trial
#19
Giovanni Corsello, Maurizio Carta, Roberto Marinello, Marina Picca, Giulio De Marco, Maria Micillo, Dante Ferrara, Patrizia Vigneri, Gaetano Cecere, Pasqualina Ferri, Paola Roggero, Giorgio Bedogni, Fabio Mosca, Lorella Paparo, Rita Nocerino, Roberto Berni Canani
Background: Fermented foods have been proposed to prevent common infectious diseases (CIDs) in children attending day care or preschool. OBJECTIVES: To investigate the efficacy of dietary supplementation with cow's skim milk fermented with the probiotic Lactobacillus paracasei CBA L74 in reducing CIDs in children attending day care or preschool. Methods: Multicenter, randomized, double-blind, placebo-controlled trial on healthy children (aged 12-48 months) consuming daily 7 grams of cow's skim milk fermented with L...
June 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28646072/genetic-and-environmental-interactions-modify-the-risk-of-diabetes-related-autoimmunity-by-6-years-of-age-the-teddy-study
#20
Jeffrey P Krischer, Kristian F Lynch, Åke Lernmark, William A Hagopian, Marian J Rewers, Jin-Xiong She, Jorma Toppari, Anette-G Ziegler, Beena Akolkar
OBJECTIVE: We tested the associations between genetic background and selected environmental exposures with respect to islet autoantibodies and type 1 diabetes. RESEARCH DESIGN AND METHODS: Infants with HLA-DR high-risk genotypes were prospectively followed for diabetes-related autoantibodies. SNPs came from the Illumina ImmunoChip and environmental exposure data were by parental report. Children were followed to age 6 years. RESULTS: Insulin autoantibodies occurred earlier than GAD antibody (GADA) and then declined, while GADA incidence rose and remained constant (significant in HLA-DR4 but not in the DR3/3 children)...
June 23, 2017: Diabetes Care
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