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https://www.readbyqxmd.com/read/28547206/glycemic-variability-in-type-1-diabetes-compared-with-degludec-and-glargine-on-the-morning-injection-an-open-label-randomized-controlled-trial
#1
Ryo Iga, Hiroshi Uchino, Ken Kanazawa, Shuki Usui, Masahiko Miyagi, Naoki Kumashiro, Hiroshi Yoshino, Yasuyo Ando, Takahisa Hirose
INTRODUCTION: Optimal adjustment of basal insulin to overcome hypoglycemia and glycemic variability (GV) depends on its duration of action and peak-less profile. Owing to the ability of long-acting basal insulin to avoid hypoglycemia, we titrated pre-meal glucose to normal fasting blood glucose, 80-110 mg/dL (4.5-6.1 mmol/L), and post-meal glucose to 80-140 mg/dL (4.5-7.8 mmol/L). The purpose of this study was to evaluate two basal insulin analogues degludec (IDeg) and glargine (IGlar), injected in the morning, for GV using continuous glucose monitoring (CGM) in type 1 diabetes (T1DM)...
May 25, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28545398/advanced-glycation-end-products-in-children-with-type-1-diabetes-and-early-reduced-diastolic-heart-function
#2
Leif Brunvand, Martin Heier, Cathrine Brunborg, Kristian F Hanssen, Drude Fugelseth, Knut Haakon Stensaeth, Knut Dahl-Jørgensen, Hanna Dis Margeirsdottir
BACKGROUND: Reduced diastolic function is an early sign of diabetes cardiomyopathy in adults and is associated with elevated levels of HbA1c and advanced glycation end products (AGEs). OBJECTIVE: To assess the associations between early reduced diastolic function and elevated levels of HbA1c and AGEs in children and adolescents with type 1 diabetes (T1D). METHODS: One hundred fourty six T1D patients (age 8-18 years) without known diabetic complications were examined with tissue Doppler imaging and stratified into two groups according to diastolic function...
May 25, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28544548/assessment-of-factors-determining-an-hba1c-concentration%C3%A2-%C3%A2-%C3%A2-7-5-in-patients-with-type-1-diabetes
#3
Eijiro Yamada, Shuichi Okada, Yasuyo Nakajima, Claire Bastie, Yuko Tagaya, Aya Osaki, Yoko Shimoda, Ryo Shibusawa, Tsugumichi Saito, Atsushi Ozawa, Masanobu Yamada
BACKGROUND: Establishing an optimal insulin regimen is crucial for maintaining glycemic control in patients with type 1 diabetes. We aimed to determine the insulin dose required to achieve a hemoglobin A1c (HbA1c) concentration ≤ 7.5% in Japanese patients with type 1 diabetes. METHODS: This multi-centered cross-sectional study was performed at 3 institutions in Japan. Among 107 patients with type 1 diabetes, 92 had no detectable endogenous insulin secretion: 39 patients had HbA1c concentration ≤ 7...
May 22, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28534688/coexisting-prostate-cancer-and-diabetes-mellitus-implications-for-patient-outcomes-and-care
#4
Nina J Karlin, Shailja B Amin, Patricia M Verona, Heidi E Kosiorek, Curtiss B Cook
OBJECTIVE: To investigate how diabetes mellitus (DM) impacts short-term overall survival for patients with prostate cancer and to examine how prostate cancer impacts glycemic control in DM. METHODS: Patients with DM and prostate cancer newly diagnosed from 2007-2014 were identified from the institutional cancer registry and matched to patients with prostate cancer but no DM according to age and year of prostate cancer diagnosis. RESULTS: The study included 276 cases and 276 controls; the mean age was 72 years, most (93%) were white, the most common Gleason score (52%) was 7, and the majority (56%) were tumor stage II...
May 23, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28531113/retrospective-evaluation-of-metformin-and-or-metformin-plus-a-new-polysaccharide-complex-in-treating-severe-hyperinsulinism-and-insulin-resistance-in-obese-children-and-adolescents-with-metabolic-syndrome
#5
Stefano Stagi, Franco Ricci, Martina Bianconi, Maria Amina Sammarco, Giovanna Municchi, Sonia Toni, Lorenzo Lenzi, Alberto Verrotti, Maurizio de Martino
Background: Pharmacological treatment of obesity and glucose-insulin metabolism disorders in children may be more difficult than in adults. Thus, we evaluate the effects of metformin in comparison with metformin plus a polysaccharide complex (Policaptil Gel Retard(®), PGR) on body weight and metabolic parameters in obese children and adolescents with metabolic syndrome (MetS). Patients and methods: We retrospectively collected 129 children and adolescents (67 girls, 62 boys; median age 12.6 years) treated for a minimum of two years with metformin and low glycemic index (LGI) diet...
May 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28525822/the-interplay-between-diabetes-depression-and-affective-temperaments-a-structural-equation-model
#6
Martino Belvederi Murri, Sara Mamberto, Lucia Briatore, Chiara Mazzucchelli, Mario Amore, Renzo Cordera
BACKGROUND: Diabetes and depression are reciprocally linked, but few studies modeled their interplay considering the influence of affective temperaments (AT) and demographic factors. METHODS: Participants with type 1 and type 2 diabetes (T1DM and T2DM, n=279) recruited from Diabetes Units were assessed with the Beck Depression Inventory (BDI), Temperament Evaluation of Memphis, Pisa, Paris and San Diego-autoquestionnaire version (TEMPS-A), Morisky Medication Adherence Scale (MMAS), Diabetes Distress Scale (DDS) and Cumulative Illness Rating Scales (CIRS)...
May 11, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28522755/increased-left-ventricular-extracellular-volume-and-enhanced-twist-function-in-type-1-diabetic-individuals
#7
Zainisha Vasanji, Ronald J Sigal, Neil Derek Eves, Debra L Isaac, Matthias G Friedrich, Kelvin Chow, Richard B Thompson
Individuals with type 1 diabetes (T1D) characteristically have high glycemic levels that over time can result in reactive fibrosis and abnormalities in myocardial function. T1 mapping with magnetic resonance imaging (MRI) can estimate the extent of reactive fibrosis by measurement of the extracellular volume fraction (ECV). The extent of alterations in the ECV and associated changes in left ventricular (LV) function and morphology in individuals with T1D is unknown. Fourteen individuals with long-term T1D and fourteen sex-, age-, and body mass index-matched controls without diabetes underwent MRI measurement of myocardial T1 and ECV values as well as LV function and morphology...
May 18, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28519964/association-between-serum-25-hydroxyvitamin-d-and-glycated-hemoglobin-levels-in-type-2-diabetes-patients-with-chronic-kidney-disease
#8
Lee Ling Lim, Yong Muh Ng, Pei San Kang, Soo Kun Lim
AIMS/INTRODUCTION: Vitamin D is suggested to influence glucose homeostasis. An inverse relationship between serum 25-hydroxyvitamin D [25(OH)D] and glycemic control in non-chronic kidney disease (CKD) patients with type 2 diabetes (T2D) was reported. We aimed to examine this association among T2D patients with CKD. MATERIALS AND METHODS: 100 T2D participants with stage 3-4 CKD were recruited. Blood for HbA1c , serum 25(OH)D, renal, and lipid profiles were drawn at enrolment...
May 18, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28515940/nivolumab-induced-autoimmune-diabetes-mellitus-presenting-as-diabetic-ketoacidosis-in-a-patient-with-metastatic-lung-cancer
#9
James Luke Godwin, Shuchie Jaggi, Imali Sirisena, Pankaj Sharda, Ajay D Rao, Ranee Mehra, Colleen Veloski
BACKGROUND: Advances in cancer immunotherapy have generated encouraging results in multiple malignancies refractory to standard chemotherapies. As the use of immune checkpoint inhibitors (ICI) proliferates, the incidence of autoimmune side effects associated with these agents, termed immune related adverse events (irAE), is expected to increase. The frequency of significant irAE in ICI treated patients is about 10-20% and early recognition is critical to prevent serious morbidity and even mortality...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28512272/apical-periodontitis-and-endodontic-treatment-in-patients-with-type-ii-diabetes-mellitus-comparative-cross-sectional-survey
#10
Leena Smadi
AIMS: The aims of this study were to investigate the prevalence of apical periodontitis (AP) in diabetes mellitus (DM) patients compared with nondiabetic patients and to examine the effect of glycemic control on the prevalence of AP. MATERIALS AND METHODS: Radiographs of a group of DM patients were compared with those of a matched nondiabetic group to identify AP. The diabetic group was subdivided according to the level of glycemic control into two subgroups: A well-controlled DM and a poorly controlled DM...
May 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28511905/hemorheological-alterations-in-adults-with-prediabetes-identified-by-hemoglobin-a1c-levels
#11
M A Marini, T V Fiorentino, F Andreozzi, G C Mannino, E Succurro, A Sciacqua, F Perticone, G Sesti
BACKGROUND AND AIMS: A link between increased blood viscosity and type 2 diabetes has been previously reported. Herein, we investigated the association of blood viscosity with prediabetes, identified by glycated hemoglobin A1c (HbA1c) according to the new American Diabetes Association criteria, and subclinical atherosclerosis. METHODS AND RESULTS: The study cohort includes 1136 non-diabetic adults submitted to anthropometrical evaluation, an oral glucose tolerance test and ultrasound measurement of carotid intima-media thickness (IMT)...
April 21, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28507727/correlation-between-hemoglobin-a1c-and-serum-lipid-profile-in-afghani-patients-with-type-2-diabetes-hemoglobin-a1c-prognosticates-dyslipidemia
#12
Arshad Hussain, Iftikhar Ali, Muhammad Ijaz, Afaq Rahim
BACKGROUND: Patients with type 2 diabetes (T2DM) have an increased prevalence of dyslipidemia, which contributes to their high risk of cardiovascular diseases (CVDs). This study is an attempt to determine the correlation between hemoglobin A1c (HbA1c) and serum lipid profile and to evaluate the importance of HbA1c as an indicator of dyslipidemia in Afghani patients with T2DM. METHODS: A total of 401 Afghani patients with T2DM (men, 175; women, 226; mean age, 51...
April 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28503154/sedentary-patterns-physical-activity-and-cardiorespiratory-fitness-in-association-to-glycemic-control-in-type-2-diabetes-patients
#13
Luís B Sardinha, João P Magalhães, Diana A Santos, Pedro B Júdice
Background: Sedentary behavior has been considered an independent risk factor for type-2 diabetes (T2D), with a negative impact on several physiological outcomes, whereas breaks in sedentary time (BST) have been proposed as a viable solution to mitigate some of these effects. However, little is known about the independent associations of sedentary pursuits, physical activity, and cardiorespiratory fitness (CRF) variables with glycemic control. We investigated the independent associations of total sedentary time, BST, moderate-to-vigorous physical activity (MVPA), and CRF with glycemic outcomes in patients with T2D...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28502503/the-effects-of-vitamin-d-and-omega-3-fatty-acid-co-supplementation-on-glycemic-control-and-lipid-concentrations-in-patients-with-gestational-diabetes
#14
Mehri Jamilian, Mansooreh Samimi, Faraneh Afshar Ebrahimi, Teibeh Hashemi, Mohsen Taghizadeh, Maryamalsadat Razavi, Marzieh Sanami, Zatollah Asemi
OBJECTIVE: This study was performed to evaluate the effects of vitamin D and omega-3 fatty acids co-supplementation on glucose metabolism and lipid concentrations in gestational diabetes (GDM) patients. METHODS: This randomized double-blind placebo-controlled clinical trial was done among 140 GDM patients. Participants were randomly divided into 4 groups to receive: (1) 1000 mg omega-3 fatty acids containing 360 mg eicosapentaenoic acid and 240 mg docosahexaenoic acid (DHA) twice a day + vitamin D placebo (n = 35); (2) 50,000 IU vitamin D every 2 weeks + omega-3 fatty acids placebo (n = 35); (3) 50,000 IU vitamin D every 2 weeks + 1000 mg omega-3 fatty acids twice a day (n = 35), and (4) vitamin D placebo + omega-3 fatty acids placebo (n = 35) for 6 weeks...
March 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28502112/sglt2-inhibitor-luseogliflozin-added-to-glucagon-like-peptide-1-receptor-agonist-liraglutide-improves-glycemic-control-with-bodyweight-and-fat-mass-reductions-in-japanese-patients-with-type-2-diabetes-a-52-week-open-label-single-arm-study
#15
Yutaka Seino, Daisuke Yabe, Takashi Sasaki, Atsushi Fukatsu, Hisae Imazeki, Hidekazu Ochiai, Soichi Sakai
AIMS/INTRODUCTION: To evaluate the safety and efficacy of luseogliflozin added to liraglutide monotherapy in Japanese individuals with type 2 diabetes (T2D). MATERIALS AND METHODS: This 52-week, multicenter, open-label, single-arm clinical study enrolled Japanese patients who had inadequate glycemic control with diet/exercise and liraglutide monotherapy. Major efficacy endpoints included the changes from baseline in HbA1c, fasting plasma glucose (FPG), and bodyweight...
May 14, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28497081/relationship-between-serum-irisin-glycemic-indices-and-renal-function-in-type-2-diabetic-patients
#16
Leila Mahmoodnia, Maryam Sadoughi, Ali Ahmadi, Marzieh Kafeshani
Introduction: Irisin is a novel peptide that plays notable role in human and animal biology and physiology. It has been reported that irisin may improve insulin resistance and related disturbances. Objectives: The aim of this investigation was to assess the relationship between serum irisin, glycemic indices, and renal function in diabetic subjects. Patients and Methods: In this cross-sectional study, a total of 102 type 2 diabetes mellitus (T2DM) patients were recruited. Blood biochemical parameters, including fasting plasma sugar (FBS), glycosylated hemoglobin (HbA1C), serum uric acid (sUA), creatinine concentration and glomerular filtration rate (GFR) were measured...
2017: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/28493502/fasiglifam-for-glycemic-control-in-patients-with-type-2-diabetes-a-phase-3-placebo-controlled-study
#17
John Marcinak, Charles Cao, Douglas Lee, Zhan Ye
AIM: To investigate the effect of fasiglifam on glycemic control in patients with type 2 diabetes mellitus (T2DM). METHODS: In total, 421 patients with T2DM and glycosylated hemoglobin (HbA1c) ≥7.0% but ≤10.5% who had been treated with diet and exercise only for ≥12 weeks prior to screening were randomized to receive fasiglifam 25 mg or 50 mg or placebo. The primary efficacy endpoint was change from baseline in HbA1c at week 24. RESULTS: Patient mean age was 53...
May 11, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28492492/the-effect-of-dietary-glycemic-properties-on-markers-of-inflammation-insulin-resistance-and-body-composition-in-postmenopausal-american-women-an-ancillary-study-from-a-multicenter-protein-supplementation-trial
#18
Violeta Stojkovic, Christine A Simpson, Rebecca R Sullivan, Anna Maria Cusano, Jane E Kerstetter, Anne M Kenny, Karl L Insogna, Jessica D Bihuniak
Controversy exists as to whether high glycemic index/glycemic load (GI/GL) diets increase the risk of chronic inflammation, which has been postulated as a pathogenic intermediary between such diets and age-related alterations in body composition and insulin resistance. We conducted an ancillary study to a randomized, double-blind trial comparing the effects of a whey protein supplement (PRO, n = 38) and a maltodextrin supplement (CHO, n = 46) on bone density to evaluate the impact of a calibrated increase in GI/GL on inflammation, insulin resistance, and body composition in a healthy aging population...
May 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28490674/physical-form-of-dietary-fat-alters-postprandial-substrate-utilization-and-glycemic-response-in-healthy-chinese-men
#19
Sze-Yen Tan, Elaine Peh, Evelyn Lau, Alejandro G Marangoni, Christiani Jeyakumar Henry
Background: Dietary fats elicit various physiological responses, with the physical form of fat reported to alter fat digestion and absorption.Objectives: The primary aims were to compare the effects of dietary fat in 2 physical forms (liquid and oleogel) and 2 degrees of saturation (saturated and polyunsaturated) on postprandial energy expenditure (EE) and substrate oxidation, glycemia, and appetite.Methods: The study was a randomized, controlled crossover trial. Sixteen normal-weight, healthy Chinese men completed the study [mean ± SD age: 28 ± 6 y; body mass index (in kg/m(2)): 22...
May 10, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28490113/mitigating-the-in-vitro-enzymatic-digestibility-of-noodles-by-aqueous-extracts-of-malay-cherry-leaves
#20
Yan Zhang, Xiaonan Sui, Dejian Huang
Aqueous extracts of Malay cherry leaves was incorporated into wheat, rice, tapioca, and potato flours with the purpose to formulate noodles with slow digestibility. In vitro digestion studies of these noodle prototypes were carried out to evaluate their digestibility under simulated gastrointestinal conditions. Upon incorporation of 2-8% of aqueous extracts, all four different types of noodles exhibited dose dependency with varying degree of digestibility. The greatest reduction in digestibility was observed in 8% tapioca noodles (69...
October 1, 2017: Food Chemistry
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