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Capsaicin

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https://www.readbyqxmd.com/read/29673543/dihydrocapsiate-supplementation-prevented-high-fat-diet-induced-adiposity-hepatic-steatosis-glucose-intolerance-and-gut-morphological-alterations-in-mice
#1
Ritesh K Baboota, Pragyanshu Khare, Priyanka Mangal, Dhirendra Pratap Singh, Kamlesh K Bhutani, Kanthi K Kondepudi, Jaspreet Kaur, Mahendra Bishnoi
Despite the lipolytic and thermogenic properties of capsaicin, its putative use as a weight-lowering dietary supplement has been limited because of the burning sensation caused by capsaicin when it comes in contact with mucous membranes. A potential alternative to capsaicin are the capsinoids, nonpungent capsaicin analogs that exhibit effects similar to capsaicin. Whereas the antiobesity properties of capsinoids have been reported, the effectiveness of FDA-approved synthetic dihydrocapsiate has not yet been investigated...
March 2018: Nutrition Research
https://www.readbyqxmd.com/read/29672123/interferon-%C3%AE-enhances-the-cough-reflex-sensitivity-via-calcium-influx-in-vagal-sensory-neurons
#2
Zheng Deng, Wenliang Zhou, Jiayang Sun, Chenhui Li, Bonian Zhong, Kefang Lai
RATIONALE: Cough hypersensitivity syndrome is often triggered by a viral infection. The viral infection might trigger cough hypersensitivity via increasing the release of interferon-γ from T lymphocytes in the lung. OBJECTIVES: To investigate effects of interferon-γ on the vagal sensory neurons and the cough reflex. METHODS: Effects of interferon-γ on the cough reflex were investigated in guinea pigs. Cellular immunofluorescence imaging, calcium imaging and patch clamp techniques were used to study effects of interferon-γ in primary cultured rat vagal sensory neurons...
April 19, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29670121/trpv1-sumoylation-regulates-nociceptive-signaling-in-models-of-inflammatory-pain
#3
Yan Wang, Yingwei Gao, Quan Tian, Qi Deng, Yangbo Wang, Tian Zhou, Qiang Liu, Kaidi Mei, Yingping Wang, Huiqing Liu, Ruining Ma, Yuqiang Ding, Weifang Rong, Jinke Cheng, Jing Yao, Tian-Le Xu, Michael X Zhu, Yong Li
Although TRPV1 channels represent a key player of noxious heat sensation, the precise mechanisms for thermal hyperalgesia remain unknown. We report here that conditional knockout of deSUMOylation enzyme, SENP1, in mouse dorsal root ganglion (DRG) neurons exacerbated thermal hyperalgesia in both carrageenan- and Complete Freund's adjuvant-induced inflammation models. TRPV1 is SUMOylated at a C-terminal Lys residue (K822), which specifically enhances the channel sensitivity to stimulation by heat, but not capsaicin, protons or voltage...
April 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29664171/capsaicin-reduces-plga-induced-fibrosis-by-promoting-m2-macrophages-and-suppressing-overall-inflammatory-response
#4
T Truong, K S Jones
Capsaicin reduced poly(lactic-co-glycolic) acid (PLGA)-induced fibrosis by promoting IL-10 secretion and suppressing alpha-smooth muscle actin (α-SMA) expression. The lifetime and efficacy of tissue engineering scaffolds are determined by the foreign body response. In this study, we investigated the in vitro and in vivo effects of capsaicin to reduce biomaterial-induced fibrosis. RAW 264.7 cells cultured on PLGA films with capsaicin responded with significant (p<0.05) upregulation in M2 markers arginase-1 and IL-10 and downregulation of M1 markers iNOS and IL-12, demonstrating the potential of capsaicin to reduce PLGA-induced inflammation...
April 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29662756/effect-of-capsaicin-sensitive-sensory-neurons-on-bone-architecture-and-mechanical-properties-in-the-rat-hindlimb-suspension-model
#5
Zong-Kang Zhang, Xia Guo, Jie Lao, Yi-Xian Qin
Background/Objective: The participation of sensory neural regulation in bone metabolism has been widely studied. However, the physiological role of sensory neural regulation in the functional adaptation to weight bearing is not clear. This study was conducted to investigate the effect of capsaicin-induced sensory neuron lesions on cancellous architecture properties in a hindlimb suspension (HLS) model. Methods: Thirty-two female rats were randomly assigned to four groups...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29661478/chronic-adriamycin-treatment-impairs-cgrp-mediated-functions-of-meningeal-sensory-nerves
#6
Éva Deák, Judit Rosta, Krisztina Boros, Gyöngyi Kis, Péter Sántha, Karl Messlinger, Gábor Jancsó, Mária Dux
Adriamycin is a potent anthracycline-type antitumor agent, but it also exerts potentially serious side effects due to its cardiotoxic and neurotoxic propensity. Multiple impairments in sensory nerve functions have been recently reported in various rat models. The present experiments were initiated in an attempt to reveal adriamycin-induced changes in sensory effector functions of chemosensitive meningeal afferents. Meningeal blood flow was measured with laser Doppler flowmetry in the parietal dura mater of adult male Wistar rats...
April 10, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29660457/a-lectin-fraction-from-green-seaweed-caulerpa-cupressoides-inhibits-inflammatory-nociception-in-the-temporomandibular-joint-of-rats-dependent-from-peripheral-mechanisms
#7
Renata Line da Conceição Rivanor, Danielle Rocha Do Val, Natássia Albuquerque Ribeiro, Felipe Dantas Silveira, Ellen Lima de Assis, Álvaro Xavier Franco, Lorena Vasconcelos Vieira, Ismael Nilo Lino de Queiroz, Hellíada Vasconcelos Chaves, Mirna Marques Bezerra, Norma Maria Barros Benevides
Temporomandibular disorders are the second most common cause of orofacial pain mediated by inflammatory compounds, which in many cases leads to chronic orofacial pain. This study assessed the antinociceptive and anti-inflammatory effects of a lectin from the green seaweed Caulerpa cupressoides (CcL) on hypernociception inflammatory in TMJ of rats and investigated the involvement of different mechanisms. Rats received i.v. CcL 30 min prior to injection of flogistic agentes or 0.9% saline into the left TMJ...
April 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29660342/investigation-of-trpv1-loss-of-function-phenotypes-in-trpv1-leu206stop-mice-generated-by-n-ethyl-n-nitrosourea-mutagenesis
#8
Thomas Christoph, Babette Kögel, Klaus Schiene, Thomas Peters, Wolfgang Schröder
N-ethyl-N-nitrosourea (ENU) random mutagenesis was used to generate a mouse model for the analysis of the transient receptor potential vanilloid 1 (TRPV1) cation channel. A transversion from T→A in exon 4 led to a Leu206Stop mutation generating a loss-of-function mutant. The TRPV1 agonist capsaicin was used to analyze functional and nociceptive parameters in vitro and in vivo in TRPV1 Leu206Stop mice and congenic C3HeB/FeJ controls. Capsaicin-induced [Ca2+ ]i changes in small diameter DRG neurons were significantly diminished in TRPV1 Leu206Stop mice and administration of capsaicin induced neither hypothermia nor nocifensive behaviour in vivo...
April 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29655911/antinociceptive-activity-of-riparin-ii-from-aniba-riparia-further-elucidation-of-the-possible-mechanisms
#9
Alyne Mara Rodrigues de Carvalho, Leonardo Freire Vasconcelos, Nayrton Flávio Moura Rocha, Emiliano Ricardo Vasconcelos Rios, Marília Leite Dias, Marta Maria de França Fonteles, Danielle Macêdo Gaspar, José Maria Barbosa Filho, Stanley Juan Chavez Gutierrez, Francisca Cléa Florenço de Sousa
Riparin II (RipII) has an anti-inflammatory activity potentially due its ability to decrease TNF-α and IL-1β production and its histamine antagonism. The objective of this study was to evaluate the role of RipII in the pain process and the possible antinociceptive mechanisms involved, using classic models of nociception. Male Swiss mice were used in the assays. Determinate the acute toxicity according to the OECD 425 test guideline. The models used were the acetic acid-, formalin-, hot plate and glutamate-induced nociception...
April 12, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29644468/-pharmacological-treatment-of-osteoarthritis-related-pain
#10
REVIEW
T A Nees, M Schiltenwolf
Joint pain due to osteoarthritis (OA) is often severe and disabling and affects a large proportion of the aging population impairing daily living and quality of life. Numerous pharmacological treatment approaches are available. Including major OA guidelines this review presents the current evidence of pharmacological therapies in OA-related pain and covers topical, oral and intraarticular treatment approaches. In patients with mild OA topical nonsteroidal antiinflammatory drugs (NSAIDs) can be recommended...
April 11, 2018: Der Schmerz
https://www.readbyqxmd.com/read/29626652/participation-of-satellite-glial-cells-of-the-dorsal-root-ganglia-in-acute-nociception
#11
Júlia Borges Paes Lemes, Tais de Campos Lima, Débora Oliveira Santos, Amanda Ferreira Neves, Fernando Silva de Oliveira, Carlos Almicar Parada, Celina Monteiro da Cruz Lotufo
At dorsal root ganglia, neurons and satellite glial cells (SGC) can communicate through ATP release and P2X7 receptor activation. SGCs are also interconnected by gap junctions and have been previously implicated in modulating inflammatory and chronic pain.We now present evidence that SGCs are also involved in processing acute nociception in rat dorsal root ganglia. Using primary dorsal root ganglia cultures we observed that calcium transients induced in neurons by capsaicin administration were followed by satellite glial cells activation...
April 4, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29625099/sinergism-between-alkaloids-piperine-and-capsaicin-with-meglumine-antimoniate-against-leishmania-infantum
#12
Francisco Marcelo Vieira-Araújo, Fernanda Cristina Macedo Rondon, Ícaro Gusmão Pinto Vieira, Francisca Noelia Pereira Mendes, José Caludio Carneiro de Freitas, Selene Maia de Morais
The primary choice of drugs to treat Leishmaniasis are the pentavalent antimony-based compounds, nevertheless these drugs presented undesirable side effects. However, safe natural compounds could be used in combination with these drugs to enhance their activity. The aim of this study was to evaluate the sinergism of capsaicin and piperine, isolated from Capsicum frutescens and Piper nigrum, respectively, in combination with meglumine antimoniate against Leishmania infantum promastigote and amastigote forms...
April 3, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29603450/nerve-growth-factor-dependent-hyperexcitability-of-capsaicin-sensitive-bladder-afferent-neurones-in-mice-with-spinal-cord-injury
#13
Takahiro Shimizu, Tsuyoshi Majima, Takahisa Suzuki, Nobutaka Shimizu, Naoki Wada, Katsumi Kadekawa, Shun Takai, Eiichiro Takaoka, Joonbeom Kwon, Anthony J Kanai, William C de Groat, Pradeep Tyagi, Motoaki Saito, Naoki Yoshimura
Nerve growth factor (NGF) has been implicated as an important mediator to induce C-fibre bladder afferent hyperexcitability, which contributes to the emergence of neurogenic lower urinary tract dysfunction (LUTD) following spinal cord injury (SCI). In this study, we determined if NGF immunoneutralization using an anti-NGF antibody (NGF-Ab) normalizes the SCI-induced changes in electrophysiological properties of capsaicin-sensitive C-fibre bladder afferent neurones in female C57BL/6 mice. The spinal cord was transected at the Th8/9 level...
March 30, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29601897/does-pain-impact-preference-the-effect-of-tonic-laboratory-pain-on-discounting-of-delayed-rewards
#14
Fenan S Rassu, Hans R Linsenbardt, Sherecce A Fields, Mary W Meagher
Chronic pain patients display elevated risk behavior on decision-making tasks, as well as increased health risk behaviors (e.g., smoking, prescription opioid abuse). Determining pain's effect on underlying cognitive processes that are associated with risk behavior is confounded by comorbidities linked with chronic pain, including depression, anxiety, and substance abuse. Therefore, to understand pain's effect on delay discounting, a behavioral process assessing the extent to which outcomes are devalued as a function of their delay, the present study evaluated the effect of laboratory pain on delay discounting in healthy young adults (N = 85)...
March 27, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29601258/fast-simultaneous-determination-of-capsaicin-dihydrocapsaicin-and-nonivamide-for-detecting-adulteration-in-edible-and-crude-vegetable-oils-by-uplc-ms-ms
#15
Chuan Zhou, Dianping Ma, Wenming Cao, Haiming Shi, Yuanrong Jiang
Capsaicinoids are pungent components in hot peppers, which have been detected in waste cooking oil. However, trace analysis of capsaicinoids in edible and crude vegetable oils is a challenging task due to the complex matrix. In this study, a simple liquid-liquid extraction and solid phase extraction (SPE) coupled with RP-UPLC-ESI-MS/MS method was developed for the quantification of capsaicinoids in edible and crude vegetable oils to screen the adulteration with waste cooking oil. This method was used to simultaneously determine 3 capsaicinoids (capsaicin, dihydrocapsaicin, and nordihydrocapsaicin) with capsaicin-d3 , and dihydrocapsaicin-d3 as internal standards...
March 30, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29599806/wentong-huoxue-cream-can-inhibit-the-reduction-of-the-pain-related-molecule-plc-%C3%AE-3-in-the-dorsal-root-ganglion-of-a-rat-model-of-diabetic-peripheral-neuropathy
#16
Chengcheng Feng, Lijuan Xu, Shiyun Guo, Qian Chen, Yuguo Shen, Deng Zang, Li Ma
WenTong HuoXue Cream (WTHX-Cream) has been shown to effectively alleviate clinical symptoms of diabetic peripheral neuropathy (DPN). This study investigated the gene and protein expression of the pain-related molecule PLC- β 3 in the dorsal root ganglion (DRG) of DPN rats. 88 specific pathogen-free male Wistar rats were randomly divided into placebo (10 rats) and DPN model (78 rats) groups, and the 78 model rats were used to establish the DPN model by intraperitoneal injection of streptozotocin and were then fed a high-fat diet for 8 weeks...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29599487/baclofen-and-gastroesophageal-reflux-disease-seeing-the-forest-through-the-trees
#17
EDITORIAL
John O Clarke, Nielsen Q Fernandez-Becker, Kirsten A Regalia, George Triadafilopoulos
Baclofen has been shown to decrease reflux events and increase lower esophageal sphincter pressure, yet has never established a clear role in the treatment of gastroesophageal reflux disease (GERD). Lei and colleagues have shown in a recent elegant study that baclofen reduces the frequency and initiation of secondary peristalsis and heightens esophageal sensitivity to capsaicin-mediated stimulation. These findings may help explain both the benefit of baclofen in conditions such as rumination and supragastric belching, as well as the apparent lack of benefit of baclofen and other GABAB agonists in long-term treatment of GERD...
March 29, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29597000/cough-reflex-sensitivity-does-not-correlate-with-the-esophageal-sensitivity-to-acid-in-patients-with-gastroesophageal-reflux-disease
#18
Martin Duricek, Lenka Nosakova, Tomas Zatko, Renata Pecova, Rudolf Hyrdel, Peter Banovcin
The sensitization of cough reflex observed in patients with gastroesophageal reflux disease (GERD) is attributed to activation of vagal C-fibers innervating the esophagus by acid, while the heartburn in GERD is mediated by esophageal acid sensitive C-fibers derived from (dorsal root ganglia) DRG. Here we explored the relationship between cough reflex sensitivity (CRS) and esophageal sensitivity to acid. We evaluated CRS to capsaicin inhalation and esophageal sensitivity to acid (intensity of heartburn evoked by esophageal infusions of acid pH = 3, 2 and 1) in patients with GERD and chronic heartburn before and 3 months after proton pump inhibitor (PPI) treatment...
March 26, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29596901/periaqueductal-gray-glutamatergic-cannabinoid-and-vanilloid-receptor-interplay-in-defensive-behavior-and-aversive-memory-formation
#19
Franklin P Back, Antonio P Carobrez
Stimulation of the midbrain periaqueductal gray matter (PAG) in humans elicits sensations of fear and impending terror, and mediates predator defensive responses in rodents. In rats, pharmacological stimulation of the dorsolateral portion of the PAG (dlPAG) with N-Methyl-d-Aspartate (NMDA) induces aversive conditioning that acts as an unconditioned stimulus (US). In the present work, we investigated the interplay between the vanilloid TRPV1 and cannabinoid CB1 receptors in the NMDA-dlPAG defensive response and in subsequent aversive learning...
March 26, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29596157/machine-learned-analysis-of-the-association-of-next-generation-sequencing-based-human-trpv1-and-trpa1-genotypes-with-the-sensitivity-to-heat-stimuli-and-topically-applied-capsaicin
#20
Dario Kringel, Gerd Geisslinger, Eduard Resch, Bruno G Oertel, Michael C Thrun, Sarah Heinemann, Jörn Lötsch
Heat pain and its modulation by capsaicin varies among subjects in experimental and clinical settings. A plausible cause is a genetic component, of which TRPV1 ion channels, by their response to both heat and capsaicin, are primary candidates. However, TRPA1 channels can heterodimerize with TRPV1 channels and carry genetic variants reported to modulate heat pain sensitivity. To address the role of these candidate genes in capsaicin induced hypersensitization to heat, pain thresholds acquired before and after topical application of capsaicin and TRPA1/TRPV1 exomic sequences derived by next-generation sequencing were assessed in n = 75 healthy volunteers and the genetic information comprised 278 loci...
March 27, 2018: Pain
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