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https://www.readbyqxmd.com/read/29228247/a-randomized-double-blind-placebo-and-active-comparator-controlled-phase-i-study-of-analgesic-antihyperalgesic-properties-of-asp8477-a-fatty-acid-amide-hydrolase-inhibitor-in-healthy-female-subjects
#1
Klaus Schaffler, Ashraf Yassen, Peter Reeh, Paul Passier
Objectives: To evaluate the analgesic/antihyperalgesic effect of ASP8477. Design: Randomized, double-blind, double-dummy, cross-over, placebo- and active comparator-controlled study. Setting: HPR Dr. Schaffler GmbH, Munich, Germany. Subjects: Healthy female subjects aged 18-65 years. Methods: Eligible subjects were randomly assigned to one of six treatment sequences and received multiple ascending doses of ASP8477, duloxetine, and placebo over three treatment periods (each consisting of 21-day dosing separated by 14-day washout periods)...
December 8, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29214107/diet-and-rosacea-the-role-of-dietary-change-in-the-management-of-rosacea
#2
REVIEW
Emma Weiss, Rajani Katta
Dietary change may play a role in the therapy of rosacea. Certain foods and beverages may act as "triggers" for rosacea exacerbations. These may be divided into heat-related, alcohol-related, capsaicin-related, and cinnamaldehyde-related. One potential pathogenic mechanism may be via the activation of transient receptor potential cation channels, which result in neurogenic vasodilatation. Further research is needed on the role of the gut skin connection in rosacea. Epidemiologic studies suggest that patients with rosacea have a higher prevalence of gastrointestinal disease, and one study reported improvement in rosacea following successful treatment of small intestinal bacterial overgrowth...
October 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29209454/kimchi-attenuates-fatty-streak-formation-in-the-aorta-of-low-density-lipoprotein-receptor-knockout-mice-via-inhibition-of-endoplasmic-reticulum-stress-and-apoptosis
#3
Minji Woo, Mijeong Kim, Jeong Sook Noh, Chan Hum Park, Yeong Ok Song
BACKGROUND/OBJECTIVES: Endoplasmic reticulum (ER) stress is positively associated with atherosclerosis via elevating macrophage cell death and plaque formation, in which oxidative stress plays a pivotal role. Antioxidative, lipid-lowering, and anti-atherogenic effects of kimchi, a Korean fermented vegetable, have been established, wherein capsaicin, ascorbic acid, quercetin, 3-(4'-hydroxyl-3',5'-dimethoxyphenyl)propionic acid, and lactic acids were identified. In this study, mechanisms of action of kimchi methanol extracts (KME) on fatty streak formation via suppression of ER stress and apoptosis in aorta were examined in low-density lipoprotein receptor knockout mice...
December 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29206105/conformational-dynamics-in-trpv1-channels-reported-by-an-encoded-coumarin-amino-acid
#4
Ximena Steinberg, Marina A Kasimova, Deny Cabezas-Bratesco, Jason D Galpin, Ernesto Ladron-de-Guevara, Federica Villa, Vincenzo Carnevale, Leon Islas, Christopher A Ahern, Sebastian E Brauchi
TRPV1 channels support the detection of noxious and nociceptive input. Currently available functional and structural data suggest that TRPV1 channels have two gates within their permeation pathway: one formed by a 'bundle-crossing' at the intracellular entrance and a second constriction at the selectivity filter. To describe conformational changes associated with channel gating, the fluorescent non-canonical amino acid coumarin-tyrosine was genetically encoded at Y671, a residue proximal to the selectivity filter...
December 5, 2017: ELife
https://www.readbyqxmd.com/read/29198921/research-progress-of-capsaicin-responses-to-various-pharmacological-challenges
#5
REVIEW
Pompy Patowary, Manash Pratim Pathak, Kamaruz Zaman, P S Raju, Pronobesh Chattopadhyay
Capsaicin, a well known vanilloid, has shown evidence of an ample variety of biological effects which make it the target of extensive research ever since its identification. In spite of the fact that capsaicin causes health hazards in quite a few ways, yet, the verity cannot be ignored that capsaicin has several therapeutic implications. In patients with hypersensitive bladders, vesical instillation of 1 mM capsaicin markedly improved urinary frequency and urge incontinence. Again, administration of capsaicin favors an augmentation in lipid mobilization and a decrease in adipose tissue mass...
November 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29194851/superiority-of-capsaicin-8-patch-versus-oral-pregabalin-on-dynamic-mechanical-allodynia-in-patients-with-peripheral-neuropathic-pain
#6
G Cruccu, T J Nurmikko, E Ernault, F K Riaz, W T McBride, M Haanpää
BACKGROUND: Dynamic Mechanical Allodynia (DMA) is a typical symptom of neuropathic pain (NP). In a recent study, the capsaicin 8% patch was noninferior to pregabalin in overall peripheral NP relief. In this study, we report the comparison of the two treatments in relieving DMA. METHODS: In a randomized, open-label, head-to-head, 8-week study, 488 patients with peripheral NP were treated with the capsaicin 8% patch (one application) or an optimized dose of pregabalin...
December 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29191767/capsaicin-the-primary-constituent-of-pepper-sprays-and-its-pharmacological-effects-on-mammalian-ocular-tissues
#7
REVIEW
Harshita Krishnatreyya, Hemanga Hazarika, Achintya Saha, Pronobesh Chattopadhyay
Capsaicin is the principal constituent of Oleoresin capsicum, or Pepper spray, as it is commonly known. Pepper sprays are frequently used in riot control situations and have been used for many years to deal with uncontrolled civil demonstrations and disturbances by defence organizations all over the world. Although capsaicin is noted for its irritant and inflammatory properties but the ocular profile of capsaicin has not been specifically studied and interpreted. The present review analyses the mammalian opthalmological profile of capsaicin and its pharmacological and toxicological manifestations including capsaicin induced corneal changes, neurogenic inflammation, neuroprotective influences on Retinal ganglion cells (RGCs), depletion of neuropeptide content in sensory nerve terminals, etc...
November 27, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29188798/capsaicin-enhances-the-antitumor-activity-of-sorafenib-in-hepatocellular-carcinoma-cells-and-mouse-xenograft-tumors-through-increased-erk-signaling
#8
Su-Shan Zhang, Yu-Hao Ni, Chen-Ru Zhao, Zhen Qiao, Hong-Xia Yu, Lu-Yao Wang, Jin-Yan Sun, Chen Du, Jia-Hao Zhang, Li-Ying Dong, KeWei Wang, Jian-Jun Gao
Sorafenib, a small inhibitor of tyrosine protein kinases, is currently the standard chemotherapy drug for the treatment of advanced hepatocellular carcinoma (HCC). Although sorafenib improves the survival of HCC patients, its efficacy is not optimal and requires further improvement. Capsaicin, the major active component of chili peppers from the genus Capsicum, is not only the agonist of TRPV1 channel, but also displays antitumor activity and enhances the sensitivity of cancer cells to cytotoxic drugs. In this study, we investigated the antitumor effects of combined sorafenib and capsaicin on HCC cells in vitro and xenograft tumors...
November 30, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29187670/differential-development-of-facial-and-hind-paw-allodynia-in-a-nitroglycerin-induced-mouse-model-of-chronic-migraine-role-of-capsaicin-sensitive-primary-afferents
#9
Sol-Ji Kim, Ji-Hee Yeo, Seo-Yeon Yoon, Soon-Gu Kwon, Jang-Hern Lee, Alvin J Beitz, Dae-Hyun Roh
Despite the relatively high prevalence of migraine or headache, the pathophysiological mechanisms triggering headache-associated peripheral hypersensitivities, are unknown. Since nitric oxide (NO) is well known as a causative factor in the pathogenesis of migraine or migraine-associated hypersensitivities, a mouse model has been established using systemic administration of the NO donor, nitroglycerin (NTG). Here we tried to investigate the time course development of facial or hindpaw hypersensitivity after repetitive NTG injection...
November 29, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29187382/opposing-effects-of-bronchopulmonary-c-fiber-subtypes-on-cough-in-guinea-pigs
#10
Yang-Ling Chou, Nanako Mori, Brendan J Canning
We have addressed the hypothesis that the opposing effects of bronchopulmonary C-fiber activation on cough are attributable to the activation of C-fiber subtypes. Coughing was evoked in anesthetized guinea pigs by citric acid (0.001-2M) applied topically in 100 µL aliquots to the tracheal mucosa. In control preparations, citric acid evoked 10±1 coughs cumulatively. Selective activation of the pulmonary C-fibers arising from the nodose ganglia with either aerosols or continuous intravenous infusion of adenosine or the 5-HT3 receptor selective agonist 2-methyl-5-HT nearly abolished coughing evoked subsequently by topical citric acid challenge...
November 29, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29185571/capsaicin-inhibits-the-metastasis-of-human-papillary-thyroid-carcinoma-bcpap-cells-through-the-modulation-of-the-trpv1-channel
#11
Shichen Xu, Li Zhang, Xian Cheng, Huixin Yu, Jiandong Bao, Rongrong Lu
Capsaicin (CAP), a potent transient receptor potential vanilloid type 1 (TRPV1) agonist, is a major ingredient of red pepper. Recently, capsaicin has attracted increasing attention owing to its multiple biological activities. However, the anticancer effects of capsaicin against various types of cancers, especially on thyroid carcinoma, have not been completely elucidated. TRPV1, which can be activated by capsaicin, plays a key role in many biological and physiological processes. In the present study, the anticancer properties of capsaicin against papillary thyroid cancer BCPAP cells were investigated...
November 29, 2017: Food & Function
https://www.readbyqxmd.com/read/29180855/aural-stimulation-with-capsaicin-ointment-improved-swallowing-function-in-elderly-patients-with-dysphagia-a-randomized-placebo-controlled-double-blind-comparative-study
#12
Eiji Kondo, Osamu Jinnouchi, Seiichi Nakano, Hiroki Ohnishi, Ikuji Kawata, Hidehiko Okamoto, Noriaki Takeda
Objective: The aim of this study was to assess whether aural stimulation with ointment containing capsaicin improves swallowing function in elderly patients with dysphagia. Study design: A randomized, placebo-controlled, double-blind, comparative study. Settings: Secondary hospital. Patients and methods: Twenty elderly dysphagic patients with a history of cerebrovascular disorder or Parkinson's disease were randomly divided into two groups: 10 receiving aural stimulation with 0...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29176651/exosomal-cargo-including-microrna-regulates-sensory-neuron-to-macrophage-communication-after-nerve-trauma
#13
Raffaele Simeoli, Karli Montague, Hefin R Jones, Laura Castaldi, David Chambers, Jayne H Kelleher, Valentina Vacca, Thomas Pitcher, John Grist, Hadil Al-Ahdal, Liang-Fong Wong, Mauro Perretti, Johnathan Lai, Peter Mouritzen, Paul Heppenstall, Marzia Malcangio
Following peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in dorsal root ganglia (DRG) sensory neurons. Here we show that DRG neuron cell bodies release extracellular vesicles, including exosomes containing miRs, upon activity. We demonstrate that miR-21-5p is released in the exosomal fraction of cultured DRG following capsaicin activation of TRPV1 receptors. Pure sensory neuron-derived exosomes released by capsaicin are readily phagocytosed by macrophages in which an increase in miR-21-5p expression promotes a pro-inflammatory phenotype...
November 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29175712/fabrication-of-capsaicin-functionalized-reduced-graphene-oxide-and-its-effect-on-proliferation-and-differentiation-of-osteoblasts
#14
Liansuo Zhai, Lin Li, Qi Zhang
Herein, we report a new simple and biological approach for the preparation of capsaicin adsorbed reduced graphene oxide (RGO), where capsaicin acts as a stabilizing and deoxygenating agent. The capsaicin that is decorated on graphene surface plays an important role as a capping agent to avoid the aggregation of graphene sheets. The capsaicin functionalized RGO stimulated the differentiation and proliferation of osteoblasts to a larger extent, which is a significant feature for the use of biomaterials in biomedical application such as in bone tissue engineering, more speciafically in the case of diseases such as osteoporosis...
November 21, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29175204/cerebral-peak-alpha-frequency-predicts-individual-differences-in-pain-sensitivity
#15
Andrew J Furman, Timothy J Meeker, Jeremy C Rietschel, Sooyoung Yoo, Janusiya Muthulingam, Mariya Prokhorenko, Michael L Keaser, Ronald N Goodman, Ali Mazaheri, David A Seminowicz
The identification of neurobiological markers that predict individual predisposition to pain are not only important for development of effective pain treatments, but would also yield a more complete understanding of how pain is implemented in the brain. In the current study using electroencephalography (EEG), we investigated the relationship between the peak frequency of alpha activity over sensorimotor cortex and pain intensity during capsaicin-heat pain (C-HP), a prolonged pain model known to induce spinal central sensitization in primates...
November 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/29175072/capsaicin-prevents-mitochondrial-damage-protects-cardiomyocytes-subjected-to-anoxia-reoxygenation-injury-mediated-by-14-3-3%C3%AE-bcl-2
#16
Jiyi Huang, Zhantu Liu, Ping Xu, Zeyu Zhang, Dong Yin, Jichun Liu, Huan He, Ming He
Capsaicin(Cap) is an active component of chili peppers that is extracted from capsicum plants. Recent studies have reported that Cap can ameliorate myocardial ischemia/reperfusion(I/R) injury. Mitochondria play an important role in pathways of apoptosis induced by myocardial I/R injury. However, the underlying mechanisms of Cap that improve mitochondrial function during I/R injury is not yet understood. The aim of this study was to evaluate whether Cap regained normal mitochondrial function in myocardial I/R injury, and to further explore the underlying mechanisms of action involved...
November 21, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29168214/transdermal-light-neuromodulation-optogenetics-in-the-murine-urinary-tract
#17
Shannon L Wallace, Robert S Kelley, Shailja Mehta, Giannina Descalzi, John A Fantl, Charles Ascher-Walsh
BACKGROUND: Optogenetics is a biologic technique that uses light to control living neurons, which have been genetically modified to express light-sensitive ion-channels. OBJECTIVES: Using an adenovirus to modify the sciatic nerves of mice, we aim to demonstrate peripheral neuromodulation of bladder pain using transdermal light. STUDY DESIGN: This pilot study is divided into: A) Confirmation and Application and B) Behavioral Step. A) Six mice were injected with AAV6-hSyn-ChR2(H134R)-eYFP virus into their sciatic nerves...
November 23, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29163755/uncoupling-protein-2-a-key-player-and-a-potential-therapeutic-target-in-vascular-diseases
#18
REVIEW
Giorgia Pierelli, Rosita Stanzione, Maurizio Forte, Serena Migliarino, Marika Perelli, Massimo Volpe, Speranza Rubattu
Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to the uncoupling protein family and plays an important role in lowering mitochondrial membrane potential and dissipating metabolic energy with prevention of oxidative stress accumulation. In the present article, we will review the evidence that UCP2, as a consequence of its roles within the mitochondria, represents a critical player in the predisposition to vascular disease development in both animal models and in humans, particularly in relation to obesity, diabetes, and hypertension...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29161255/neurogenic-mediators-contribute-to-local-edema-induced-by-micrurus-lemniscatus-venom
#19
Luciana Lyra Casais-E-Silva, Catarina Teixeira
BACKGROUND/AIMS: Micrurus is one of the four snake genera of medical importance in Brazil. Coral snakes have a broad geographic distribution from the southern United States to Argentina. Micrurine envenomation is characterized by neurotoxic symptoms leading to dyspnea and death. Moreover, various local manifestations, including edema formation, have been described in patients bitten by different species of Micrurus. Thus, we investigated the ability of Micrurus lemniscatus venom (MLV) to induce local edema...
November 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29159769/diversity-effect-of-capsaicin-on-different-types-of-skeletal-muscle
#20
Gan Zhou, Lina Wang, Yaqiong Xu, Kelin Yang, Lv Luo, Leshan Wang, Yongxiang Li, Jiawen Wang, Gang Shu, Songbo Wang, Ping Gao, Xiaotong Zhu, Qianyun Xi, Jiajie Sun, Yongliang Zhang, Qingyan Jiang
Capsaicin is a major pungent content in green and red peppers which are widely used as spice, and capsaicin may activate different receptors. To determine whether capsaicin has different effects on different types of skeletal muscle, we applied different concentrations (0, 0.01, and 0.02%) of capsaicin in the normal diet and conducted a four-week experiment on Sprague-Dawley rats. The fiber type composition, glucose metabolism enzyme activity, and different signaling molecules' expressions of receptors were detected...
November 20, 2017: Molecular and Cellular Biochemistry
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