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https://www.readbyqxmd.com/read/29665951/statistical-considerations-for-pediatric-multidrug-resistant-tuberculosis-efficacy-trials
#1
S Kim, J A Seddon, A J Garcia-Prats, G Montepiedra
The inclusion of newly licensed or repurposed drugs in regimens to treat children for multidrug-resistant tuberculosis (TB) may lead to treatment that is shorter than traditional regimens and composed only of oral medications. As an all-oral regimen may be more acceptable and have a better safety profile than current regimens, demonstrating non-inferiority may be satisfactory. Demonstrating non-inferior efficacy requires setting a non-inferiority margin and safeguarding study assay sensitivity. Multi-arm, multistage designs may currently not be appropriate in pediatric trials because of the lack of sensitive and specific intermediate outcomes...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29662841/effect-of-mixed-fruit-and-vegetable-juice-on-alcohol-hangovers-in-healthy-adults
#2
Min-Ju Kim, Sang-Wook Lim, Jong-Hyun Kim, Da-Jeong Choe, Jung-In Kim, Min-Jung Kang
The purpose of this study was to investigate the effects of mixed fruit and vegetable juice on alcohol hangover in healthy adults in a randomized crossover trial. Angelica keiskei /green grape/pear juice (AGP juice) was a mixture of A. keiskei juice, green grape juice, and pear juice at 1:1:1 ratio. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activities of AGP juice were measured in vitro . Fifteen healthy adults consumed alcohol (1.25 g/kg weight), and either water (control group) or AGP juice (AGP juice group)...
March 2018: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29662541/cabozantinib-in-the-treatment-of-advanced-renal-cell-carcinoma-in-adults-following-prior-vascular-endothelial-growth-factor-targeted-therapy-clinical-trial-evidence-and-experience
#3
REVIEW
Susanne Osanto, Tom van der Hulle
Cabozantinib is an oral multitargeted tyrosine kinase inhibitor (TKI) that potently inhibits MET and AXL, both associated with poor prognosis in renal cell carcinoma (RCC), next to vascular endothelial growth factor receptor 2, KIT, FLT3 and RET. Chronic treatment with vascular endothelial growth factor receptor (VEGFR)-targeting sunitinib upregulates MET and AXL in RCC, indicating that cabozantinib may be particularly effective in patients with advanced RCC whose disease progressed on prior VEGFR-targeted treatment...
March 2018: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29658816/a-mixed-treatment-comparison-of-toxicity-of-gemcitabine-combined-with-different-targeted-drugs-in-the-treatment-of-advanced-or-metastatic-pancreatic-cancer
#4
Penpa Dorjee, Zi-Wen Long
The mixed treatment comparison study was performed in order to compare the toxicities of Gemcitabine and different targeted drug combinations in the treatment of advanced/metastatic pancreatic cancer (PC). Searches were performed from the inception of PubMed and Cochrane Library databases to February 2017. This study included randomized controlled trials (RCTs) of Gemcitabine and different targeted drug combinations in the treatment of advanced/metastatic PC. Odds ratio (OR) values were calculated by direct and indirect comparisons, and the surface under the cumulative ranking curves (SUCRA) were drawn...
April 16, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29655852/aidi-injection-plus-platinum-based-chemotherapy-for-stage-iiib-iv-non-small-cell-lung-cancer-a-meta-analysis-of-42-rcts-following-the-prisma-guidelines
#5
Jue Wang, Guochun Li, Lili Yu, Tingting Mo, Qibiao Wu, Zhou Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: Aidi injection is one of the most commonly used Chinese patent medicines for advanced non-small cell lung cancer (NSCLC). It is made from an extraction of Mylabris Phalerata, Radix Astragalus, Radix Ginseng, and Acanthopanax Senticosus. AIM OF THE STUDY: The objective of this study is to evaluate the efficacy and safety of Aidi injection in combination with platinum-based chemotherapy for stage IIIB/IV NSCLC. MATERIALS AND METHODS: A systematic review and meta-analysis were performed following the PRISMA (the Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines...
April 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29651970/randomized-double-blind-placebo-controlled-trial-of-celecoxib-for-prevention-of-skin-toxicity-in-patients-receiving-radiation-therapy-for-breast-cancer
#6
Arash Ghasemi, Behzad Danesh, Jamshid Yazdani, Seyed Jalal Hosseinimehr
BACKGROUND: The skin toxicity-induced by ionizing radiation may limit the duration of treatment and may lead discomfort to quality life of patients during radiotherapy. OBJECTIVE: The purpose of this randomized, placebo-controlled, double-blind study was to investigate the preventive effect of oral administration of celecoxib (CLX) on the acute radiation-induced skin toxicity in patients with breast cancer. METHODS: Sixty breast cancer patients were randomly assigned to use CLX (400 mg per day) or placebo capsules during radiotherapy...
April 11, 2018: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29645086/erlotinib-plus-either-pazopanib-or-placebo-in-patients-with-previously-treated-advanced-non-small-cell-lung-cancer-a-randomized-placebo-controlled-phase-2-trial-with-correlated-serum-proteomic-signatures
#7
David R Spigel, Howard A Burris, F Anthony Greco, Kent C Shih, Victor G Gian, Andrew J Lipman, Davey B Daniel, David M Waterhouse, Lindsey Finney, John V Heymach, John D Hainsworth
BACKGROUND: This study compared the efficacy and safety of treatment with erlotinib plus pazopanib versus erlotinib plus placebo in patients with previously treated advanced non-small cell lung cancer (NSCLC). METHODS: Patients with progressive-stage IV NSCLC after either 1 or 2 previous chemotherapy regimens were randomized to receive erlotinib (150 mg by mouth daily) with either pazopanib (600 mg by mouth daily) or placebo. During treatment, patients were evaluated every 8 weeks until disease progression or unacceptable toxicity...
April 12, 2018: Cancer
https://www.readbyqxmd.com/read/29617737/efficacy-and-safety-of-ivermectin-against-trichuris-trichiura-in-preschool-and-school-aged-children-a-randomized-controlled-dose-finding-trial
#8
David Wimmersberger, Jean T Coulibaly, Jessica Schulz, Maxim Puchkow, Jörg Huwyler, Yves N'Gbesso, Jan Hattendorf, Jennifer Keiser
Background: Although trichuriasis affects millions of children worldwide, recommended drugs lack efficacy and new treatment options are urgently needed. Ivermectin has promising potential to complement the anthelminthic armamentarium. Methods: A randomized placebo-controlled trial was conducted in rural Côte d'Ivoire to provide evidence on the efficacy and safety of ascending oral ivermectin dosages in preschool-aged children and in schoolchildren infected with Trichuris trichiura...
March 30, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29617381/prevention-of-colonic-neoplasia-with-polyethylene-glycol-a-short-term-randomized-placebo-controlled-double-blinded-trial
#9
Ramesh K Wali, Laura Bianchi, Sonia Kupfer, Mart De La Cruz, Borko Jovanovic, Christopher Weber, Michael J Goldberg, L M Rodriguez, Raymond Bergan, David Rubin, Mary Beth Tull, Ellen Richmond, Beth Parker, Seema Khan, Hemant K Roy
Chemoprevention represents an attractive modality against colorectal cancer (CRC) although widespread clinical implementation of promising agents (e.g. aspirin/NSAIDS) have been stymied by both suboptimal efficacy and concerns over toxicity. This highlights the need for better agents. Several groups, including our own, have reported that the over-the-counter laxative polyethylene glycol (PEG) has remarkable efficacy in rodent models of colon carcinogenesis. In this study, we undertook the first randomized human trial to address the role of PEG in prevention of human colonic neoplasia...
2018: PloS One
https://www.readbyqxmd.com/read/29615003/role-of-cytarabine-in-paediatric-acute-promyelocytic-leukemia-treated-with-the-combination-of-all-trans-retinoic-acid-and-arsenic-trioxide-a-randomized-controlled-trial
#10
Li Zhang, Yao Zou, Yumei Chen, Ye Guo, Wenyu Yang, Xiaojuan Chen, Shuchun Wang, Xiaoming Liu, Min Ruan, Jiayuan Zhang, Tianfeng Liu, Fang Liu, Benquan Qi, Wenbin An, Yuanyuan Ren, Lixian Chang, Xiaofan Zhu
BACKGROUND: The combination of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) has been suggested to be safe and effective for adult acute promyelocytic leukaemia (APL). As of 2010, the role of cytarabine (Ara-C) in APL was controversial. The aim of this study was to test the efficacy and safety of ATRA and ATO in paediatric APL patients. Also, we assessed whether Ara-C could be omitted in ATO and ATRA- based trials in children. METHODS: We performed a randomized controlled trial in paediatric APL patients (≤14 years of age) in our hospital from May 2010 to December 2016...
April 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29614764/how-safe-is-ginger-rhizome-for-decreasing-nausea-and-vomiting-in-women-during-early-pregnancy
#11
REVIEW
Julien Stanisiere, Pierre-Yves Mousset, Sophie Lafay
Ginger, Zingiber officinale Roscoe, is increasingly consumed as a food or in food supplements. It is also recognized as a popular nonpharmacological treatment for nausea and vomiting of pregnancy (NVP). However, its consumption is not recommended by all countries for pregnant women. Study results are heterogeneous and conclusions are not persuasive enough to permit heath care professionals to recommend ginger safely. Some drugs are also contraindicated, leaving pregnant women with NVP with few solutions. We conducted a review to assess effectiveness and safety of ginger consumption during early pregnancy...
April 1, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29609937/can-aidi-injection-improve-overall-survival-in-patients-with-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis-of-25-randomized-controlled-trials
#12
REVIEW
Zheng Xiao, Chengqiong Wang, Rui Zhou, Shanshan Hu, Nian Yi, Jihong Feng, Minghua Zhou, Shiyu Liu, Ling Chen, Jie Ding, Qihai Gong, Fushan Tang, Xiaofei Li
OBJECTIVES: Aidi injection can significantly improve clinical response and reduce radiochemotherapy related toxicity. Can Aidi injection improve the survival in non-small-cell lung cancer (NSCLC)? Therefore, to further reveal it, we systematically evaluated all related studies. METHODS: We collected all studies about Aidi injection for NSCLC in Medline, Embase, Web of Science(ISI), China National Knowledge Infrastructure Database(CNKI), Chinese Scientific Journals Full-Text Database(VIP), Wanfang, China Biological Medicine Database (CBM), Cochrane Central Register of Controlled Trials (CENTRAL), Chinese clinical trial registry (Chi-CTR) and WHO International Clinical Trials Registry Platform (WHO-ICTRP), and US-clinical trials (established to June 2016)...
April 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29609646/stereotactic-body-radiotherapy-boost-dose-of-18-gy-vs-21-gy-in-combination-with-androgen-deprivation-therapy-and-whole-pelvic-radiotherapy-for-intermediate-or-high-risk-prostate-cancer-a-study-protocol-for-a-randomized-controlled-pilot-trial
#13
Yeon Joo Kim, Hanjong Ahn, Choung-Soo Kim, Jae-Lyun Lee, Young Seok Kim
BACKGROUND: Combination therapy using external-beam radiotherapy (EBRT) with a brachytherapy boost has demonstrated superior biochemical control than dose-escalated EBRT alone. Whereas brachytherapy is disadvantageous because it is an invasive procedure, stereotactic body-radiotherapy (SBRT) using CyberKnife could emulate the dose distribution of brachytherapy and is a non-invasive and safe modality to control intra-fractional movement. We therefore adopted SBRT using CyberKnife as a boost therapy after whole-pelvic radiotherapy (WPRT)...
April 2, 2018: Trials
https://www.readbyqxmd.com/read/29606522/radiotherapy-quality-assurance-for-the-rtog-0834-eortc-26053-22054-ncic-ctg-cec-1-catnon-intergroup-trial-concurrent-and-adjuvant-temozolomide-chemotherapy-in-newly-diagnosed-non-1p-19q-deleted-anaplastic-glioma-individual-case-review-analysis
#14
André N Abrunhosa-Branquinho, Raquel Bar-Deroma, Sandra Collette, Enrico Clementel, Yan Liu, Coen W Hurkmans, Loïc Feuvret, Karen Van Beek, Martin van den Bent, Brigitta G Baumert, Damien C Weber
BACKGROUND: The EORTC phase III 26053-22054/ RTOG 0834/NCIC CTG CEC.1/CATNON intergroup trial was designed to evaluate the impact on concurrent and adjuvant temozolomide chemotherapy in newly diagnosed non-1p/19q deleted anaplastic gliomas. The primary endpoint was overall survival. We report the results of retrospective individual case reviews (ICRs) for the first patient randomized per institution to detect the compliance with the study protocol. MATERIAL AND METHODS: Sixty-nine institutions were required to submit the radiotherapy plan of their first randomized patient...
March 29, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29606258/treatment-of-iga-nephropathy-recent-advances-and-prospects
#15
REVIEW
Rosanna Coppo
IgA nephropathy, identified 50 years ago in France, is the most frequent glomerular disease worldwide. The course is variable, but in most of the cases there is a relentless decline in renal function, reaching end-stage renal failure in 10-60% of the cases after 10 years and in 40% after 20 years. These data justify the interest for finding a suitable therapeutic approach particularly in progressive cases. A supportive care, including renin-angiotensin system inhibitors is the priority in cases with slowly declining renal function, particularly when developing proteinuria...
April 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29604186/the-clinical-efficacy-and-safety-of-baminercept-a-lymphotoxin-%C3%AE-receptor-fusion-protein-in-primary-sj%C3%A3-gren-s-syndrome-results-from-a-randomized-double-blind-placebo-controlled-phase-ii-trial
#16
E William St Clair, Alan N Baer, Chungwen Wei, Ghaith Noaiseh, Anne Parke, Andreea Coca, Tammy O Utset, Mark C Genovese, Daniel J Wallace, James McNamara, Karen Boyle, Lynette Keyes-Elstein, Jeffrey L Browning, Nathalie Franchimont, Kira Smith, Joel M Guthridge, Ignacio Sanz, Judith A James
OBJECTIVE: To evaluate the clinical efficacy and safety of baminercept, a lymphotoxin β receptor IgG fusion protein (LTβR-Ig), for the treatment of primary Sjögren's syndrome (SS) and explore its possible mechanisms of action. METHODS: In this multicenter trial, 52 patients with primary SS were randomized in a 2:1 ratio to receive subcutaneous injections of 100 mg of baminercept every week for 24 weeks or matching placebo. The primary endpoint was the change between screening and week 24 in stimulated whole salivary flow (SWSF)...
March 31, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29594244/combining-radiotherapy-and-ipilimumab-induces-clinically-relevant-radiation-induced-abscopal-effects-in-metastatic-melanoma-patients-a-systematic-review
#17
REVIEW
Rodolfo Chicas-Sett, Ignacio Morales-Orue, Delvys Rodriguez-Abreu, Pedro Lara-Jimenez
Background: In the last years, limited studies have described that radiotherapy could produce important distant responses in unirradiated sites, the so-called "abscopal effect". Recent evidence suggests that radiotherapy induces antigen release from tumor, in this way activating the immune system. However, radiotherapy alone is rarely enough to induce the systemic response requested for control of the metastases. With the advent of immunotherapy, the immune checkpoint inhibitors (ICI) have demonstrated impressive efficacy in various metastatic cancers...
February 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29589552/evaluation-and-management-of-the-child-with-thyrotoxicosis
#18
Alexander K C Leung, Alexander A C Leung
BACKGROUND: Uncontrolled thyrotoxicosis, especially in early infancy, may cause irreversible damage to the central nervous system as well as profound effects on the function of many organs. Thyrotoxicosis has multiple etiologies and treatment depends on the underlying etiology. An accurate diagnosis is essential so that appropriate treatment can be initiated without undue delay. OBJECTIVE: To review in depth the evaluation, diagnosis, and treatment of children with thyrotoxicosis...
March 26, 2018: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/29588814/environmental-interventions-based-on-the-health-belief-model-and-the-ecological-social-model-in-the-continuation-of-consumption-of-rice-free-from-toxic-metals
#19
Leili Shafiei, Parvaneh Taymoori, Afshin Maleki, Kourosh Sayehmiri
Background and aim: Continuation of healthy nutritional behaviors is one of the important factors in effectiveness of educational intervention programs. The aim of this research is to compare the Health Belief Model and the Ecological-social model in reducing consumption of rice contaminated with toxic metals after completion of environmental intervention and continuation of consumption of healthy rice. Methods: This research was the implementation of a six-month randomized controlled trial interventional program in two groups' interventions along with a control group, with 80 people for each group totally, amounting to 240 women, between 18 and 50 years of age in Ilam, Iran in 2014...
January 2018: Electronic Physician
https://www.readbyqxmd.com/read/29584549/randomized-phase-ii-trial-of-carboplatin-paclitaxel-versus-carboplatin-paclitaxel-trastuzumab-in-uterine-serous-carcinomas-that-overexpress-human-epidermal-growth-factor-receptor-2-neu
#20
Amanda N Fader, Dana M Roque, Eric Siegel, Natalia Buza, Pei Hui, Osama Abdelghany, Setsuko K Chambers, Angeles Alvarez Secord, Laura Havrilesky, David M O'Malley, Floor Backes, Nicole Nevadunsky, Babak Edraki, Dirk Pikaart, William Lowery, Karim S ElSahwi, Paul Celano, Stefania Bellone, Masoud Azodi, Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Peter E Schwartz, Alessandro D Santin
Purpose Uterine serous carcinoma is a rare, aggressive variant of endometrial cancer. Trastuzumab is a humanized monoclonal antibody that targets human epidermal growth factor receptor 2 (HER2)/neu, a receptor overexpressed in 30% of uterine serous carcinoma. This multicenter, randomized phase II trial compared carboplatin-paclitaxel with and without trastuzumab in patients with advanced or recurrent uterine serous carcinoma who overexpress HER2/neu. Methods Eligible patients had primary stage III or IV or recurrent HER2/neu-positive disease...
March 27, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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