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Stanislav Južnič
Barbara Celjska je bila gotovo najbogatejša alkimistka vseh časov. Prispevek skuša pojasniti kakšni poskusi so potekali v njenem laboratoriju in nakazati, katere tehniške kemijske naprave je utegnila pri tem uporabljati. Ker je bila večina leteh iz zlahka lomljivih snovi, bi bilo njihovo iskanje brškone brez haska, saj ni veliko upanja za njihovo ohranitev. Barbara of Cilli was certainly the richest female alchemist of all times. The article tries to explain what kind of experiments she carried out in her laboratory and indicate which technical chemical plant she likely has used...
June 2017: Acta Chimica Slovenica
José Vieira Leitão
The Benedictine monk Benito Jerónimo Feijoo (1676-1764) is now considered one of the major figures of the Spanish and Iberian Enlightenment. However his work, both in Spain and in Portugal, was far from being universally acclaimed. His critical approach to the subject of alchemy in his essay "Piedra Filosofal," published in the third volume of his magisterial Teatro Crítico Universal (1726-1739), sparked an unexpected response from the Portuguese alchemist Anselmo Castelo Branco, who sought to refute Feijoo's claims in his own work, the Ennoea...
January 30, 2017: Ambix
Stanislav Južnič
One of the most important Mid-European professor with more than six thousand academic descendants was the leading Slovenian erudite Jurij Vega. In broader sense, Vega's and other applied sciences of the south of Holy Roman Empire of German Nationality were connected with the mercury mine of Idrija during the last half of millennia. The Idrija Mine used to be one of the two top European producers of mercury, the basic substance of atomistic alchemists. Idrija Mine contributions to the history of techniques, their examinations and approbations is comparable to the other Mid-European achievements...
December 2016: Acta Chimica Slovenica
I M Donaldson
Around the year 1643, Joan Baptista van Helmont, a Flemish chemist, alchemist and physician who had devised what he claimed to be a new form of medicine, proposed a 'challenge' to traditional Galenic physicians to compare treatment of fever by traditional methods and by a regime which did not involve bloodletting and purging. Two groups of patients were to be treated and 'casting of lots' was to be used - in some way not specified in detail - to decide who received which treatment. This 'challenge' has been regarded as the first proposal for the use of randomisation in a clinical trial...
September 2016: Journal of the Royal College of Physicians of Edinburgh
Rafał T Prinke
The Polish alchemist Michael Sendivogius is best known for the influential Novum lumen chymicum, a work composed of three separate texts. Sendivogius's authorship was questioned in the mid-seventeenth century, and these reservations are still held by some modern historians. On the other hand, other early modern and modern readers not only accepted his authorship of all three texts, but also ascribed as many as eleven texts to him. This paper discusses the key works published under the anagrammatised name of Sendivogius with the aim of resolving the authorship question...
November 3, 2016: Ambix
Claus Priesner
This paper explores the relationship between three illustrated alchemical treatises, all of which are associated with Jewish adepts: the famous Le Livre des figures hieroglyphiques attributed to Nicolas Flamel, and two treatises published in 1735 in Erfurt-the Uraltes Chymisches Werckh and the Donum Dei. The Werckh is supposedly written by Rabbi Abraham Eleazar, while the Donum Dei is attributed to an ancient alchemist-cabalist, Rabbi Samuel Baruch. I argue that these authors are fictitious, and that both works were in fact written in the early eighteenth century by their supposed editor, the probably pseudonymous Julius Gervasius...
February 2016: Ambix
Nancy Rawson, Ali Quraishi, Thomas J Bruno
Since the days of the alchemist, the observation that some substances have a smell while other substances do not has been a source of fascination. The sense of smell, or olfaction, is our least understood sense, however it is important for many human functions, including digestion, food selection and hazard avoidance. The detailed explanation of why individual chemicals (called odorants) might have a particular smell is still elusive. The situation with mixtures of odorants is even more complex and interesting...
November 2011: Journal of Research of the National Institute of Standards and Technology
Biagio Ricciardi, Elisabetta Ricciardi, Carlo Alberto Ricciardi
Arnaldo de Villanova, was a Catalan Physician, born in Villanova de Grau, a suburb of Valencia - Spain about 1235. He died off the coast of Genoa in 1311 during a sea voyage departing from Messina in Sicily, during a diplomatic mission by Pope Clement V in Avignon on orders by the King of Sicily. He was a so famous and clever scientist of the thirteenth century, to give his name to the Universitary Hospital of Montpellier - France. His interests ranged from theology, to politics, medicine, and anymore alchemy...
February 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Achsah Philip, Avani Desai, Phouc Anne Nguyen, Patrick Birney, Anthony Colavecchia, Rusol Karralli, Lindsey Smith, Dirk Lorimer, Gwen Burgess, Kyle Munch, Nelvin Daniel, Jason Lionetti, Kevin W Garey
PURPOSE: Pharmacy leader development over time was analyzed using the seven action logics. METHODS: As part of an ongoing leadership seminar series, students were required to select a visionary pharmacy leader and conduct a structured interview to evaluate pharmacy leaders' action logics. A standardized questionnaire comprising 13 questions was created by the class. Questions addressed leadership qualities during the leaders' early years, education years, and work years...
January 15, 2016: American Journal of Health-system Pharmacy: AJHP
Ramaswamy Govindan, Sumithra J Mandrekar, David E Gerber, Geoffrey R Oxnard, Suzanne E Dahlberg, Jamie Chaft, Shakun Malik, Margaret Mooney, Jeffrey S Abrams, Pasi A Jänne, David R Gandara, Suresh S Ramalingam, Everett E Vokes
The treatment of patients with metastatic non-small cell lung cancer (NSCLC) is slowly evolving from empirical cytotoxic chemotherapy to personalized treatment based on specific molecular alterations. Despite this 10-year evolution, targeted therapies have not been studied adequately in patients with resected NSCLC who have clearly defined actionable mutations. The advent of next-generation sequencing has now made it possible to characterize genomic alterations in unprecedented detail. The efforts begun by The Cancer Genome Atlas project to understand the complexities of the genomic landscape of lung cancer will be supplemented further by studying a large number of tumor specimens...
December 15, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Geoffrey R Oxnard, Colleen Watt, Dennis Wigle, Judy C Boughey
No abstract text is available yet for this article.
September 2015: Bulletin of the American College of Surgeons
Ryan S Alden, Sumithra J Mandrekar, Geoffrey R Oxnard
Genotype-directed targeted therapies have revolutionized the treatment of metastatic non-small cell lung cancer (NSCLC) but they have not yet been comprehensively studied in the adjuvant setting. Previous trials of adjuvant targeted therapy in unselected early stage NSCLC patients showed no benefit versus placebo, however retrospective data suggests improved disease free survival (DFS) with epidermal growth factor receptor (EGFR) inhibitors in patients with appropriate molecular alterations. A definitive prospective, randomized, placebo-controlled trial of targeted therapies for NSCLC is needed to determine the efficacy of targeted therapy following surgical resection and standard adjuvant therapy...
September 2015: Chinese Clinical Oncology
Greg van Anders, Daphne Klotsa, Andrew S Karas, Paul M Dodd, Sharon C Glotzer
Starting with the early alchemists, a holy grail of science has been to make desired materials by modifying the attributes of basic building blocks. Building blocks that show promise for assembling new complex materials can be synthesized at the nanoscale with attributes that would astonish the ancient alchemists in their versatility. However, this versatility means that making a direct connection between building-block attributes and bulk structure is both necessary for rationally engineering materials and difficult because building block attributes can be altered in many ways...
October 27, 2015: ACS Nano
Philippe Hernigou
Hans von Gerssdorff and Hieronymus Brunschwig, who flourished in Germany in the latter half of the fifteenth century, have both left early printed treatises on Surgery which give excellent woodcuts showing pictures of instruments, operations, and costumes, at the end of the medieval period. Hieronymus Brunschwig or Hieronymus Brunschwygk (ca. 1450 - ca. 1512), was a German surgeon (wundartzot), alchemist and botanist. He was notable for his methods of treatment of gunshot wounds. His most influential book was the Buch der Cirurgia...
October 2015: International Orthopaedics
John A Norris
The Sarepta, oder Bergpostill (1562) by Johann Mathesius is a book of sermons on mining and mineral subjects in which the composition and generation of metals in ore veins are discussed in terms of the sulfur-mercurius theory. Gur was an embodiment of mercurius or of sulfur and mercurius. Sulfur was evident in the sulfurous odor of the mines, in the supposed effects of subterranean heat, and in the deposition of mineral sulfur during the roasting of the ores. The toxic smoke given off during smelting was considered to be an additional manifestation of mercurius...
2014: Osiris
Jennifer M Rampling
An influential strand of English alchemy was the pursuit of the "vegetable stone," a medicinal elixir popularized by George Ripley (d. ca. 1490), made from a metallic substance, "sericon." Yet the identity of sericon was not fixed, undergoing radical reinterpretation between the fifteenth and seventeenth centuries as Ripley's lead-based practice was eclipsed by new methods, notably the antimonial approach of George Starkey (1628-65). Tracing "sericonian" alchemy over 250 years, I show how alchemists fed their practical findings back into textual accounts, creating a "feedback loop" in which the authority of past adepts was maintained by exegetical manipulations--a process that I term "practical exegesis...
2014: Osiris
Sofia Lampaki, George Lazaridis, Konstantinos Zarogoulidis, Ioannis Kioumis, Antonis Papaiwannou, Katerina Tsirgogianni, Anastasia Karavergou, Theodora Tsiouda, Vasilis Karavasilis, Lonny Yarmus, Kaid Darwiche, Lutz Freitag, Antonios Sakkas, Angeliki Kantzeli, Sofia Baka, Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis
Historical, the non-small cell lung cancer (NSCLC) was as a united disease entity and the chemotherapy to the metastatic cancer had limited results. Recent studies for the metastatic non-small cell lung cancer led to the ascertainment that the NSCLC does not constitute exclusively a disease entity, but different neoplasms guided from different molecular paths, different biological behavior and at extension requires different confrontation. Thus the new direction for the therapeutic approach of NSCLC is henceforth the most individualized approach based on the activated molecular paths of tumor...
2015: Journal of Cancer
Sumithra J Mandrekar, Suzanne E Dahlberg, Richard Simon
Clinical trial design strategies have evolved over the past few years as a means to accelerate the drug development process so that the right therapies can be delivered to the right patients. Basket, umbrella, and adaptive enrichment strategies represent a class of novel designs for testing targeted therapeutics in oncology. Umbrella trials include a central infrastructure for screening and identification of patients, and focus on a single tumor type or histology with multiple subtrials, each testing a targeted therapy within a molecularly defined subset...
2015: American Society of Clinical Oncology Educational Book
Laura Orsolini, Gabriele Duccio Papanti, Giulia Francesconi, Fabrizio Schifano
Within online drug fora communities, there are some "educated and informed" users who can somehow provide reliable information on psychoactive compounds and combinations. These users, also called "e-psychonauts," may possess levels of technical knowledge relating to a range of novel psychoactive substances (NPS). The present project aimed at identifying and describing the e-psychonauts' socio-demographic characteristics and their motivations and patterns of drug intake. A netnographic research methodology, carried out through an unobtrusive observational approach of a list of cyber drug communities (blogs, fora, Facebook, and Twitter pages) was carried out...
May 2015: Cyberpsychology, Behavior and Social Networking
D E Gerber, G R Oxnard, R Govindan
The identification of druggable molecular alterations represents one of the greatest advances in cancer treatment. Such progress is particularly evident for lung cancer, which now has numerous molecularly defined subsets such as epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements. However, understanding of the significance of these genomic alterations is largely limited to incurable, metastatic lung cancer. ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial) is a National Cancer Institute-sponsored initiative to address these questions in earlier-stage disease...
May 2015: Clinical Pharmacology and Therapeutics
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