cervical dysplasia WHO nomenclature

BACKGROUND: A new nationwide screening strategy was implemented in Germany in January 2020. No data are available for women referred to certified dysplasia units for secondary clarification after primary diagnosis by a local physician. We therefore investigated combined testing with Papanicolaou smears and high-risk human papillomavirus (hrHPV) and compared the data with the final histological findings. METHODS: Between January 2015 and October 2020, all referred women who underwent colposcopy of the uterine cervix in our certified dysplasia unit were included...

The majority of precancerous lesions of the lower female genital tract (intraepithelial neoplasia, IN) are caused by human papillomavirus (HPV) infections resulting in cellular atypia and in turn an altered tissue architecture. Depending on the pathogenesis, a distinction is made between vulvar intraepithelial neoplasia (VIN) classified as classical VIN associated with high-risk HPV infections (u-VIN) and differentiated VIN (d-VIN), which is associated with lichen sclerosus et atrophicus and p53 alterations...

BACKGROUND: The incidence of abnormal cytological results in pregnant women is as much as 7%. Often there is need to advise pregnant women with an abnormal cervical cytology result and monitor them throughout pregnancy, without endangering the mother or child. PATIENTS AND METHODS: We retrospectively analyzed all pregnant women with an abnormal cervical cytology or condyloma in our dysplasia clinic between 01/2008 and 12/2011. Classification of the cervical cytological results was performed according to the Munich II nomenclature and a biopsy was obtained from most patients...

OBJECTIVE: This population based study investigates the patterns of care women with high grade cervical dysplasia receive. METHODS: The study population includes women with a first time diagnosis of a high grade dysplasia (ASC-H, AGUS, HSIL, malignancy, carcinoma) from 2000 to 2005 as identified in a centralized cervical smear database. Record linkages were then carried out to other databases of health care services to characterize management. RESULTS: Women (43,712) with a high grade dysplasia had a mean age of 37...

OBJECTIVE: To estimate the risk of significant pathology from atypical glandular cell (AGC) Pap tests classified by the 2001 Bethesda system and to assess potential differences in AGC management practices between physician specialties. METHODS: A chart study was conducted to assess outcomes from AGC Pap tests diagnosed during 2001-2005. RESULTS: One hundred thirty-one AGC Pap tests were identified from 84,748 Pap tests. The incidence of AGC was 0...

BACKGROUND: Developed in 1989, the Bethesda System has largely replaced previous classifications of Papanicolaou (Pap) smears from the uterine cervix. The system is binary, dividing smears into two groups - low-grade, squamous, epithelial lesions (LSIL) or high-grade, squamous, epithelial lesions (HSIL). A third category, atypical squamous cells of undetermined significance (ASCUS), is used to classify minimal cellular changes that do not satisfy the criteria for the low- or high-grade categories...

The evaluation of smears of the uterine cervix on the basis of descriptive terms requires the practitioner to be acquainted with the nomenclature used by cytologists. A theoretical scheme is provided which correlates the diagnostic features encountered with their respective clinical implications.