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cervical dysplasia WHO nomenclature

L-C Horn, C E Brambs, R Handzel, G Mehlhorn, D Schmidt, K Schierle
The majority of precancerous lesions of the lower female genital tract (intraepithelial neoplasia, IN) are caused by human papillomavirus (HPV) infections resulting in cellular atypia and in turn an altered tissue architecture. Depending on the pathogenesis, a distinction is made between vulvar intraepithelial neoplasia (VIN) classified as classical VIN associated with high-risk HPV infections (u-VIN) and differentiated VIN (d-VIN), which is associated with lichen sclerosus et atrophicus and p53 alterations...
November 2016: Der Pathologe
Melanie Henes, Felix Neis, Katharina Rall, Thomas Iftner, Annette Staebler, Tanja Fehm, Ralf Rothmund
BACKGROUND: The incidence of abnormal cytological results in pregnant women is as much as 7%. Often there is need to advise pregnant women with an abnormal cervical cytology result and monitor them throughout pregnancy, without endangering the mother or child. PATIENTS AND METHODS: We retrospectively analyzed all pregnant women with an abnormal cervical cytology or condyloma in our dysplasia clinic between 01/2008 and 12/2011. Classification of the cervical cytological results was performed according to the Munich II nomenclature and a biopsy was obtained from most patients...
February 2013: Anticancer Research
Rachel Kupets, Lawrence Paszat
OBJECTIVE: This population based study investigates the patterns of care women with high grade cervical dysplasia receive. METHODS: The study population includes women with a first time diagnosis of a high grade dysplasia (ASC-H, AGUS, HSIL, malignancy, carcinoma) from 2000 to 2005 as identified in a centralized cervical smear database. Record linkages were then carried out to other databases of health care services to characterize management. RESULTS: Women (43,712) with a high grade dysplasia had a mean age of 37...
June 1, 2011: Gynecologic Oncology
Christopher P DeSimone, Misty E Day, Molly M Tovar, Charles S Dietrich, Mary L Eastham, Susan C Modesitt
OBJECTIVE: To estimate the risk of significant pathology from atypical glandular cell (AGC) Pap tests classified by the 2001 Bethesda system and to assess potential differences in AGC management practices between physician specialties. METHODS: A chart study was conducted to assess outcomes from AGC Pap tests diagnosed during 2001-2005. RESULTS: One hundred thirty-one AGC Pap tests were identified from 84,748 Pap tests. The incidence of AGC was 0...
June 2006: Obstetrics and Gynecology
R Bollmann, M Bollmann, D E Henson, M Bodo
BACKGROUND: Developed in 1989, the Bethesda System has largely replaced previous classifications of Papanicolaou (Pap) smears from the uterine cervix. The system is binary, dividing smears into two groups - low-grade, squamous, epithelial lesions (LSIL) or high-grade, squamous, epithelial lesions (HSIL). A third category, atypical squamous cells of undetermined significance (ASCUS), is used to classify minimal cellular changes that do not satisfy the criteria for the low- or high-grade categories...
June 25, 2001: Cancer
G W Locher, U Herrmann, P A Grétillat
The evaluation of smears of the uterine cervix on the basis of descriptive terms requires the practitioner to be acquainted with the nomenclature used by cytologists. A theoretical scheme is provided which correlates the diagnostic features encountered with their respective clinical implications.
April 10, 1976: Schweizerische Medizinische Wochenschrift
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