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"Nitrate" and "inflammation"

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https://www.readbyqxmd.com/read/29248723/iodine-prevents-the-increase-of-testosterone-induced-oxidative-stress-in-a-model-of-rat-prostatic-hyperplasia
#1
Michelle Quintero-García, Evangelina Delgado-González, Ana Sánchez-Tusie, Mario Vázquez, Carmen Aceves, Brenda Anguiano
Oxidative stress and inflammation are involved in the development and/or progression of benign prostatic hyperplasia (BPH). Molecular iodine (I2) induces antiproliferative and apoptotic effects in prostate cancer cells, but it is unknown if I2 regulates oxidative stress in the normal and/or tumoral prostate. The purpose of this study was to analyze the effects of I2 and celecoxib (Cxb) on oxidative stress and inflammation in a model of prostatic hyperplasia. Cxb was used as positive control of cyclooxygenase-2 (COX-2) inhibition...
December 14, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29233018/type-1-diabetic-patients-have-better-endothelial-function-after-simultaneous-pancreas-kidney-transplantation-than-after-kidney-transplantation-with-continued-insulin-therapy
#2
Jacek Ziaja, Adrian P Kowalik, Aureliusz Kolonko, Dorota Kamińska, Aleksander J Owczarek, Agata Kujawa-Szewieczek, Mariusz A Kusztal, Joanna Badura, Dominika Bożek-Pająk, Piotr Choręza, Agnieszka Zakrzewska, Robert Król, Stefan Chłopicki, Marian Klinger, Andrzej Więcek, Jerzy Chudek, Lech Cierpka
The purpose of this study was to analyse the influence of simultaneous pancreas-kidney or kidney transplantation on endothelial function and systemic inflammation in type 1 diabetic patients with end-stage renal disease. In 39 simultaneous pancreas-kidney, 39 type 1 diabetic kidney and 52 non-diabetic kidney recipients, flow-mediated dilatation was measured. Additionally, blood glycated haemoglobin, serum creatinine and lipids, plasma nitrites [Formula: see text] and nitrates, asymmetric dimethylarginine, soluble vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and E-selectin, high-sensitivity C-reactive protein, tumour necrosis factor-α, interleukin 1β and interleukin 6 concentrations were assessed...
December 1, 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29229986/high-fat-diet-induced-obesity-impairs-insulin-signaling-in-lungs-of-allergen-challenged-mice-improvement-by-resveratrol
#3
Diana M André, Marina C Calixto, Carolina Sollon, Eduardo C Alexandre, Edith B G Tavares, Ana C A Naime, Gabriel F Anhê, Edson Antunes
Insulin resistance plays an important role in obesity-associated asthma exacerbations. Using a murine model of allergic airway inflammation, we evaluated the insulin signaling transmission in lungs of obese compared with lean mice. We further evaluated the effects of the polyphenol resveratrol in the pulmonary insulin signaling. In lean mice, insulin stimulation significantly increased phosphorylations of AKT, insulin receptor substrate 1 (IRS-1) and insulin receptor β (IRβ) in lung tissue and isolated bronchi (p < 0...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228007/conjugation-of-nitrated-acetaminophen-to-der-p1-amplifies-peripheral-blood-monocyte-response-to-der-p1
#4
Ryan G Thomas, Brenda M Rivera Reyes, Benjamin M Gaston, Nelki B Rivera Acosta, Ilya R Bederman, Laura A Smith, Morgan T Sutton, Benlian Wang, John F Hunt, Tracey L Bonfield
BACKGROUND: An association of acetaminophen use and asthma was observed in the International Study of Asthma and Allergies in Childhood study. However there are no clear mechanisms to explain an association between acetaminophen use and immunologic pathology. In acidic conditions like those in the stomach and inflamed airway, tyrosine residues are nitrated by nitrous and peroxynitrous acids. The resulting nitrotyrosine is structurally similar to 2,4-dinitrophenol and 2,4-dinitrochlorobenzene, known haptens that enhance immune responses by covalently binding proteins...
2017: PloS One
https://www.readbyqxmd.com/read/29214688/nootkatone-confers-hepatoprotective-and-anti-fibrotic-actions-in-a-murine-model-of-liver-fibrosis-by-suppressing-oxidative-stress-inflammation-and-apoptosis
#5
Amani Kurdi, Kamal Hassan, Balaji Venkataraman, Mohanraj Rajesh
In this study, the hepatoprotective and anti-fibrotic actions of nootkatone (NTK) were investigated using carbon tetrachloride (CCl4 )-induced liver fibrosis in mice. CCl4 administration elevated serum aspartate and alanine transaminases levels, respectively. In addition, CCl4 produced hepatic oxidative and nitrative stress, characterized by diminished hemeoxygenase-1 expression, antioxidant defenses, and accumulation of 4-hydroxynonenal and 3-nitrotyrosine. Furthermore, CCl4 administration evoked profound expression of pro-inflammatory cytokine expressions such as tumor necrosis factor-α, monocyte chemoattractant protein-1, and interleukin-1β in hepatic tissues, which corroborated with nuclear factor κB activation...
December 7, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29202488/acute-tadalafil-administration-increases-plasma-fatty-acids-without-changes-in-the-inflammatory-response-in-healthy-men
#6
Roberta Ceci, Guglielmo Duranti, Paolo Sgrò, Stefania Sabatini, Luigi Di Luigi
PURPOSE: Tadalafil, the phosphodiesterase type 5 inhibitor (PDE5I), has been shown to reduce visceral adipose tissue in rabbit and to improve lean mass content in non-obese men. In order to clarify this effect in humans, in the present study we determined the impact of an acute oral tadalafil administration on lipolysis by evaluating plasma free fatty acids (FFAs) and glycerol. FFAs are potential modulator of inflammation response that we evaluated through tumor necrosis factor alpha (TNFα), interleukin 6 (IL6), interleukin 8 (IL8) and interleukin 10 (IL10) plasma levels...
December 5, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29187674/nitrative-dna-damage-in-cultured-macrophages-exposed-to-indium-oxide
#7
Tahmina Afroz, Yusuke Hiraku, Ning Ma, Sharif Ahmed, Shinji Oikawa, Shosuke Kawanishi, Mariko Murata
OBJECTIVES: Indium compounds are used in manufacturing displays of mobile phones and televisions. However, these materials cause interstitial pneumonia in exposed workers. Animal experiments demonstrated that indium compounds caused lung cancer. Chronic inflammation is considered to play a role in lung carcinogenesis and fibrosis induced by particulate matters. 8-Nitroguanine (8-nitroG) is a mutagenic DNA lesion formed during inflammation and may participate in carcinogenesis. To clarify the mechanism of carcinogenesis, we examined 8-nitroG formation in indium-exposed cultured cells...
November 29, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/29165355/acute-effects-of-nitrate-rich-beetroot-juice-on-blood-pressure-hemostasis-and-vascular-inflammation-markers-in-healthy-older-adults-a-randomized-placebo-controlled-crossover-study
#8
Kyle Raubenheimer, Danica Hickey, Michael Leveritt, Robert Fassett, Joaquin Ortiz de Zevallos Munoz, Jason D Allen, David Briskey, Tony J Parker, Graham Kerr, Jonathan M Peake, Natalie M Pecheniuk, Oliver Neubauer
Aging is associated with a vasoconstrictive, pro-coagulant, and pro-inflammatory profile of arteries and a decline in the bioavailability of the endothelium-derived molecule nitric oxide. Dietary nitrate elicits vasodilatory, anti-coagulant and anti-inflammatory effects in younger individuals, but little is known about whether these benefits are evident in older adults. We investigated the effects of 140 mL of nitrate-rich (HI-NI; containing 12.9 mmol nitrate) versus nitrate-depleted beetroot juice (LO-NI; containing ≤0...
November 22, 2017: Nutrients
https://www.readbyqxmd.com/read/29132974/topical-electrophilic-nitro-fatty-acids-potentiate-cutaneous-inflammation
#9
Alicia R Mathers, Cara D Carey, Meaghan E Killeen, Sonia R Salvatore, Laura K Ferris, Bruce A Freeman, Francisco J Schopfer, Louis D Falo
Endogenous electrophilic fatty acids mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction and gene expression. Nitro-fatty acids and other electrophilic fatty acids may thus be useful for the prevention and treatment of immune-mediated diseases, including inflammatory skin disorders. In this regard, subcutaneous (SC) injections of nitro oleic acid (OA-NO2), an exemplary nitro-fatty acid, inhibit skin inflammation in a model of allergic contact dermatitis (ACD). Given the nitration of unsaturated fatty acids during metabolic and inflammatory processes and the growing use of fatty acids in topical formulations, we sought to further study the effect of nitro-fatty acids on cutaneous inflammation...
November 10, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29124567/dimethyl-fumarate-modulates-oxidative-stress-and-inflammation-in-organs-after-sepsis-in-rats
#10
Amanda Della Giustina, Sandra Bonfante, Graciela Freitas Zarbato, Lucinéia Gainski Danielski, Khiany Mathias, Aloir Neri de Oliveira, Leandro Garbossa, Taise Cardoso, Maria Eduarda Fileti, Raquel Jaconi De Carli, Mariana Pereira Goldim, Tatiana Barichello, Fabricia Petronilho
Sepsis is defined as life-threatening organ dysfunction induced by a disrupted host response to infecting pathogens. Evidences suggest that oxidative stress is intrinsically related to sepsis progression. Dimethyl fumarate (DMF) is a novel oral therapeutic agent with anti-oxidant properties which exerts protective effects through activation of nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2). Thus, the aim of this study is to evaluate the effect of DMF in different organs of rats submitted to an animal model of sepsis...
November 9, 2017: Inflammation
https://www.readbyqxmd.com/read/29098483/irisin-alleviates-advanced-glycation-end-products-induced-inflammation-and-endothelial-dysfunction-via-inhibiting-ros-nlrp3-inflammasome-signaling
#11
Xian Deng, Wei Huang, Juan Peng, Ting-Ting Zhu, Xiao-Lei Sun, Xiang-Yu Zhou, Hui Yang, Jian-Feng Xiong, Hu-Qiang He, You-Hua Xu, Yan-Zheng He
The activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome have been implicated in the initiation or progression of atherosclerosis. Recent research showed that irisin, a newly discovered adipomiokine, alleviates endothelial dysfunction in type 2 diabetes partially via reducing oxidative/nitrative stresses, suggesting that irisin may be a promising candidate for the treatment of vascular complications of diabetes. However, the association between irisin and NLRP3 inflammasome in the pathogenesis of atherosclerosis remains unclear...
November 2, 2017: Inflammation
https://www.readbyqxmd.com/read/29096811/the-role-of-nitroglycerin-and-other-nitrogen-oxides-in-cardiovascular-therapeutics
#12
REVIEW
Sanjay Divakaran, Joseph Loscalzo
The use of nitroglycerin in the treatment of angina pectoris began not long after its original synthesis in 1847. Since then, the discovery of nitric oxide as a biological effector and better understanding of its roles in vasodilation, cell permeability, platelet function, inflammation, and other vascular processes have advanced our knowledge of the hemodynamic (mostly mediated through vasodilation of capacitance and conductance arteries) and nonhemodynamic effects of organic nitrate therapy, via both nitric oxide-dependent and -independent mechanisms...
November 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29082918/the-unique-structural-and-functional-features-of-cxcl12
#13
REVIEW
Rik Janssens, Sofie Struyf, Paul Proost
The CXC chemokine CXCL12 is an important factor in physiological and pathological processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation, because it activates and/or induces migration of hematopoietic progenitor and stem cells, endothelial cells and most leukocytes. Therefore, CXCL12 activity is tightly regulated at multiple levels. CXCL12 has the unique property of existing in six splice variants in humans, each having a specific tissue distribution and in vivo activity. Controlled splice variant transcription and mRNA stability determine the CXCL12 expression profile...
October 30, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29075366/the-synthetic-lignan-secoisolariciresinol-diglucoside-prevents-asbestos-induced-nlrp3-inflammasome-activation-in-murine-macrophages
#14
Ralph A Pietrofesa, Patrick Woodruff, Wei-Ting Hwang, Priyal Patel, Shampa Chatterjee, Steven M Albelda, Melpo Christofidou-Solomidou
BACKGROUND: The interaction of asbestos with macrophages drives two key processes that are linked to malignancy: (1) the generation of reactive oxygen species (ROS)/reactive nitrogen species (RNS) and (2) the activation of an inflammation cascade that drives acute and chronic inflammation, with the NLRP3 inflammasome playing a key role. Synthetic secoisolariciresinol diglucoside (SDG), LGM2605, is a nontoxic lignan with anti-inflammatory and antioxidant properties and was evaluated for protection from asbestos in murine peritoneal macrophages (MF)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29055824/selenium-containing-indolyl-compounds-kinetics-of-reaction-with-inflammation-associated-oxidants-and-protective-effect-against-oxidation-of-extracellular-matrix-proteins
#15
Angela M Casaril, Marta T Ignasiak, Christine Y Chuang, Beatriz Vieira, Nathalia B Padilha, Luke Carroll, Eder J Lenardão, Lucielli Savegnago, Michael J Davies
Activated white blood cells generate multiple oxidants in response to invading pathogens. Thus, hypochlorous acid (HOCl) is generated via the reaction of myeloperoxidase (from neutrophils and monocytes) with hydrogen peroxide, and peroxynitrous acid (ONOOH), a potent oxidizing and nitrating agent is formed from superoxide radicals and nitric oxide, generated by stimulated macrophages. Excessive or misplaced production of these oxidants has been linked to multiple human pathologies, including cardiovascular disease...
October 18, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29051304/consequences-of-advanced-aging-on-renal-function-in-chronic-hyperandrogenemic-female-rat-model-implications-for-aging-women-with-polycystic-ovary-syndrome
#16
Chetan N Patil, Lorraine C Racusen, Jane F Reckelhoff
Polycystic ovary syndrome (PCOS) is the most common endocrine and reproductive disorder in premenopausal women, characterized by hyperandrogenemia, metabolic syndrome, and inflammation. Women who had PCOS during their reproductive years remain hyperandrogenemic after menopause. The consequence of chronic hyperandrogenemia with advanced aging has not been studied to our knowledge. We have characterized a model of hyperandrogenemia in female rats and have aged them to 22-25 months to mimic advanced aging in hyperandrogenemic women, and tested the hypothesis that chronic exposure to hyperandrogenemia with aging has a deleterious effect on renal function...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29032011/sitagliptin-enhances-the-neuroprotective-effect-of-pregabalin-against-pentylenetetrazole-induced-acute-epileptogenesis-in-mice-implication-of-oxidative-inflammatory-apoptotic-and-autophagy-pathways
#17
Manar A Nader, Hayam Ateyya, Mohamed El-Shafey, Nagla A El-Sherbeeny
The current investigation aimed at studying the anti-epileptogenic effect of sitagliptin. The possible effect of the drug in combination with pregabalin in pentylenetetrazole (PTZ)- induced seizures was studied. In addition, the postulated mechanisms that could mediate such effect were explored namely, suppression of oxidative stress and neuro-inflammatory markers, autophagy and apoptosis. Seven days prior to PTZ (60 mg/kg, sc) injection, mice were treated with sitagliptin (5, 15, and 60 mg/kg, twice daily, orally) or pregabalin (30 mg/kg, once daily, orally) or their combination...
October 11, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29031221/effects-of-particulate-matter-from-straw-burning-on-lung-fibrosis-in-mice
#18
Yang Hu, Liu-Sheng Wang, Yan Li, Qiu-Hong Li, Chun-Lin Li, Jian-Min Chen, Dong Weng, Hui-Ping Li
OBJECTIVE: To investigate the impacts of particulate matter 2.5 (PM2.5) from straw burning on the acute exacerbation of lung fibrosis in mice and the preventive effects of N-acetylcysteine (NAC). METHODS: The composition, particle size, and 30-min concentration change in an exposure system of the PM2.5 from straw-burning were determined. Forty C57BL male mice were equally randomized to two groups: bleomycin (BLM)-induced lung fibrosis with an exposure to air (BLM+air) and BLM+PM2...
October 7, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29030007/pretreatment-of-a-matrix-metalloproteases-inhibitor-and-aprotinin-attenuated-the-development-of-acute-pancreatitis-induced-lung-injury-in-rat-model
#19
Kuang-En Chu, Yao Fong, David Wang, Chao Fuh Chen, Diana Yu-Wung Yeh
OBJECTIVE: Acute lung injury (ALI) is one of the most common extra-pancreatic complications of acute pancreatitis. In this study, we examined the protective effect of protease inhibitor aprotinin and a matrix metalloproteinase inhibitor (MMPi) on pulmonary inflammation in rats with severe pancreatitis-associated ALI. METHOD: A rat model of acute pancreatitis (AP) was established by injecting sodium glycodeoxycholate (GDOC) into the pancreatic duct. Pharmacological interventions included pretreatment with a protease inhibitor aprotinin (10mg/kg) and a matrix metalloproteinase inhibitor (MMPi, 100g/kg)...
October 6, 2017: Immunobiology
https://www.readbyqxmd.com/read/28963087/metformin-influences-on-respiratory-system-in-obese-mice-induced-by-postnatal-overnutrition
#20
Maycon Daniel Dias, Melissa Goulart, Cecilia Dalécio, Silvia Enes-Marques, Évila da Silva Lopes Salles, Marina Venâncio, Elisângela Monteiro Pereira, Valdemar Antonio Paffaro, Erika Kristina Incerpi, Roseli Soncini
Many studies have confirmed the merits of metformin to treat type 2 diabetes, but few studies have addressed its effect on the respiratory system. Moreover, vascular endothelial growth factor (VEGF) is critical to many lung functions. In this way, we evaluated the metformin impact on the lung in treated obese Swiss mice, induced by postnatal overnutrition. Glucose and insulin were detected and the insulin resistance index (HOMA) was calculated; inflammatory cells and nitrite/nitrate concentration (NOx) was quantified from bronchoalveolar lavage, collagen and lung VEGF-a was analysed in the lung tissue and lung mechanics were evaluated by methacholine-induced bronchoconstriction...
September 28, 2017: Respiratory Physiology & Neurobiology
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