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"Nitrate" and "inflammation"

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https://www.readbyqxmd.com/read/28079248/inhibition-of-matrix-metalloproteinase-9-by-a-barbiturate-nitrate-hybrid-ameliorates-dextran-sulphate-sodium-induced-colitis-effect-on-inflammation-related-genes
#1
Shane O'Sullivan, Jun Wang, Maria T Pigott, Neil Docherty, Noreen Boyle, Samuel Kana Lis, John F Gilmer, Carlos Medina
BACKGROUND AND PURPOSE: Matrix metalloproteinase-9 is upregulated in Ulcerative Colitis and implicated in the pathology of the disease. In this study, we have examined the effects of a barbiturate-based MMP inhibitor incorporating a nitric oxide donor/mimetic group (dinitrate-barbiturate) in the intestinal injury induced by dextran sulphate sodium (DSS). EXPERIMENTAL APPROACH: In-vivo experiments were carried out using male Wistar rats given DSS 5% ad libitum in drinking water...
January 12, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28059788/silicic-acid-and-beer-consumption-reverses-the-metal-imbalance-and%C3%A2-the%C3%A2-prooxidant-status-induced-by%C3%A2-aluminum-nitrate-in-mouse-brain
#2
María José González-Muñoz, Alba Garcimartán, Isabel Meseguer, Carmen José Mateos-Vega, José María Orellana, Antonio Peña-Fernández, Juana Benedí, Francisco J Sánchez-Muniz
BACKGROUND: Emerging evidence suggests that by affecting mineral balance, aluminum (Al) may enhance some events associated with neurodegenerative diseases. AIM: To examine the effect of Al(NO3)3 exposure on brain Al, cooper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), silicon (Si), and zinc (Zn) levels, and the metal-change implication in brain oxidant and inflammatory status. METHODS: Four groups of six-week-old male NMRI mice were treated for three months: i) controls, administrated with deionized water; ii) Al, which received Al(NO3)3; iii) Al+silicic acid, which were given Al(NO3)3 plus silicic acid; and iv) Al+beer, which received Al(NO3)3 plus beer...
December 3, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28057862/antiinflammatory-actions-of-inorganic-nitrate-stabilize-the-atherosclerotic-plaque
#3
Rayomand S Khambata, Suborno M Ghosh, Krishnaraj S Rathod, Tharssana Thevathasan, Federica Filomena, Qingzhong Xiao, Amrita Ahluwalia
Reduced bioavailable nitric oxide (NO) plays a key role in the enhanced leukocyte recruitment reflective of systemic inflammation thought to precede and underlie atherosclerotic plaque formation and instability. Recent evidence demonstrates that inorganic nitrate (NO3(-)) through sequential chemical reduction in vivo provides a source of NO that exerts beneficial effects upon the cardiovascular system, including reductions in inflammatory responses. We tested whether the antiinflammatory effects of inorganic nitrate might prove useful in ameliorating atherosclerotic disease in Apolipoprotein (Apo)E knockout (KO) mice...
January 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28053087/targeting-traf3ip2-by-genetic-and-interventional-approaches-inhibits-ischemia-reperfusion-induced-myocardial-injury-and-adverse-remodeling
#4
John M Erikson, Anthony J Valente, Srinivas Mummidi, Hemanthkumar Kandikattu, Vincent G DeMarco, Shawn B Bender, William P Fay, Ulrich Siebenlist, Bysani Chandrasekar
Re-establishing blood supply is the primary goal for reducing myocardial injury in subjects with ischemic heart disease. Paradoxically, reperfusion results in oxidative stress and a marked inflammatory response in the heart. TRAF3IP2 (TRAF3 Interacting Protein 2; previously known as CIKS or Act1) is an oxidative stress-responsive cytoplasmic adapter molecule that is an upstream regulator of both IκB kinase (IKK) and c-Jun N-terminal kinase (JNK), and an important mediator of autoimmune and inflammatory responses...
January 4, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28006762/h2s-attenuates-lps-induced-acute-lung-injury-by-reducing-oxidative-nitrative-stress-and-inflammation
#5
Hong-Xia Zhang, Shu-Juan Liu, Xiao-Lu Tang, Guo-Li Duan, Xin Ni, Xiao-Yan Zhu, Yu-Jian Liu, Chang-Nan Wang
BACKGROUND: Hydrogen sulfide (H2S), known as the third endogenous gaseous transmitter, has received increasing attention because of its diverse effects, including angiogenesis, vascular relaxation and myocardial protection.We aimed to investigate the role of H2S in oxidative/nitrative stress and inflammation in acute lung injury (ALI) induced by endotoxemia. METHODS: Male ICR mice were divided in six groups: (1) Control group; (2) GYY4137treatment group; (3) L-NAME treatment group; (4) lipopolysaccharide (LPS) treatment group; (5) LPS with GYY4137 treatment group; and (6) LPS with L-NAME treatment group...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27998900/randomised-double-blind-placebo-controlled-study-investigating-the-effects-of-inorganic-nitrate-on-vascular-function-platelet-reactivity-and-restenosis-in-stable-angina-protocol-of-the-nitrate-oct-study
#6
Krishnaraj S Rathod, Daniel A Jones, T J A Van-Eijl, Hilda Tsang, Helen Warren, Stephen M Hamshere, Vikas Kapil, Ajay K Jain, Andrew Deaner, Neil Poulter, Mark J Caulfield, Anthony Mathur, Amrita Ahluwalia
INTRODUCTION: The mainstay treatment for reducing the symptoms of angina and long-term risk of heart attacks in patients with heart disease is stent implantation in the diseased coronary artery. While this procedure has revolutionised treatment, the incidence of secondary events remains a concern. These repeat events are thought to be due, in part, to continued enhanced platelet reactivity, endothelial dysfunction and ultimately restenosis of the stented artery. In this study, we will investigate whether a once a day inorganic nitrate administration might favourably modulate platelet reactivity and endothelial function leading to a decrease in restenosis...
December 20, 2016: BMJ Open
https://www.readbyqxmd.com/read/27989963/tuning-constitutive-and-pathological-inflammation-in-the-gut-via-the-interaction-of-dietary-nitrate-and-polyphenols-with-host-microbiome
#7
Bárbara Rocha, Carla Nunes, João Laranjinha
Chronic inflammation is currently recognized as a critical process in modern-era epidemics such as diabetes, obesity and neurodegeneration. However, little attention is paid to the constitutive inflammatory pathways that operate in the gut and that are mandatory for local welfare and the prevention of such multi-organic diseases. Hence, the digestive system, while posing as a barrier between the external environment and the host, is crucial for the balance between constitutive and pathological inflammatory events...
October 28, 2016: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/27989792/enterosalivary-nitrate-metabolism-and-the-microbiome-intersection-of-microbial-metabolism-nitric-oxide-and-diet-in-cardiac-and-pulmonary-vascular-health
#8
REVIEW
Carl D Koch, Mark T Gladwin, Bruce A Freeman, Jon O Lundberg, Eddie Weitzberg, Alison Morris
Recent insights into the bioactivation and signaling actions of inorganic, dietary nitrate and nitrite now suggest a critical role for the microbiome in the development of cardiac and pulmonary vascular diseases. Once thought to be the inert, end-products of endothelial-derived nitric oxide (NO) heme-oxidation, nitrate and nitrite are now considered major sources of exogenous NO that exhibit enhanced vasoactive signaling activity under conditions of hypoxia and stress. The bioavailability of nitrate and nitrite depend on the enzymatic reduction of nitrate to nitrite by a unique set of bacterial nitrate reductase enzymes possessed by specific bacterial populations in the mammalian mouth and gut...
December 16, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27989752/comprehensive-analysis-of-the-formation-and-stability-of-peroxynitrite-derived-8-nitroguanine-by-lc-ms-ms-strategy-for-the-quantitative-analysis-of-cellular-8-nitroguanine
#9
Chiung-Wen Hu, Yuan-Jhe Chang, Yu-Wen Hsu, Jian-Lian Chen, Tsu-Shing Wang, Mu-Rong Chao
Peroxynitrite is a major oxidizing and nitrating biological agent formed at sites of inflammation. Peroxynitrite can cause DNA damage and is thought to contribute to inflammation-related carcinogenesis. This study describes a sensitive and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the direct determination of peroxynitrite-derived 8-nitroguanine (8-nitroGua) in DNA hydrolysates. This method exhibited a sensitive detection limit of 3 fmol and inter- and intraday imprecision of < 10% and was applied to systemically examine the formation and stability of peroxynitrite-derived 8-nitroGua in different DNA substrates under various conditions...
October 29, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27960621/molecular-mechanisms-underlying-histological-and-biochemical-changes-induced-by-nitrate-in-rat-liver-and-the-efficacy-of-s-allylcysteine
#10
Asmaa A A Kattaia, Samia A Abd El-Baset, Eman M Mohamed, Rehab S Abdul-Maksou, Yara M Elfakharany
This study was designed to investigate structural and ultra-structural changes induced by nitrate in rat liver, examine their molecular basis, and evaluate the possible protective role of S-Allylcysteine (SAC). Adult male albino rats were assigned to: control, SAC, nitrate, and nitrate+ SAC groups. Serum ALT and AST were measured. Liver samples were processed for light and electron microscope examinations, biochemical analysis, real-time PCR, and immunohistochemistry of heat shock protein 70 (HSP70) and Bcl-2...
December 14, 2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/27940398/therapeutic-role-of-nitric-oxide-as-emerging-molecule
#11
REVIEW
Sahil Kumar, Rajesh K Singh, T R Bhardwaj
NO has many physiological roles; in inflammation, pain, rheumatoid arthritis, immune system, gastroprotection, as antioxidant and reported to be a free radical scavenger.Intensive research on the biological functions of NO and other reactive nitrogen oxide species demands exogenous sources of NO donors as research tools and pharmaceuticals. Since the mid-1980s, the development of new NO donors has offered several advantages over theprevious NO donors, such as spontaneous release of NO, donation of NO under controlled rates, and even the targeting of NO to certain tissues...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27940053/paeonol-alleviates-epirubicin-induced-renal-injury-in-mice-by-regulating-nrf2-and-nf-%C3%AE%C2%BAb-pathways
#12
Jing Wu, Linlin Xu, Chao Sun, Bin Zhang, Juan Li, Jing Sun, Ying Zhang, Deqing Sun
Renal injury is a dose-dependent side effect of epirubicin that limits its clinical application in the field of tumor chemotherapy. Paeonol is an active ingredient with a variety of biological activities, including the prevention of multiple antineoplastic-induced toxicities. In the present study, we assessed the renoprotective effect of paeonol on epirubicin-induced nephrotoxicity and investigated the underlying mechanism. Renal function, kidney histology, oxidative stress, nitrative stress, inflammation, apoptotic proteins and the effects on signaling pathways were investigated...
December 6, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27936913/anti-inflammatory-effect-of-selenium-nanoparticles-on-the-inflammation-induced-in-irradiated-rats
#13
M A El-Ghazaly, N Fadel, E Rashed, A El-Batal, S A Kenawy
Selenium (Se) has been reported to possess anti-inflammatory properties, but its bioavailability and toxicity are considerable limiting factors. The present study aimed to investigate the possible anti-inflammatory and analgesic effects of selenium nanoparticles (Nano-Se) on inflammation induced in irradiated rats. Paw volume and nociceptive threshold were measured in carrageenan-induced paw edema and hyperalgesia model. Leukocytic count, tumor necrosis factor-α (TNF-α), prostaglandin E2 (PGE2), thiobarbituric acid reactive substances (TBAR), and total nitrate/nitrite (NOx) were estimated in the exudate collected from 6 day old air pouch model...
October 12, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27936461/pterostilbene-protects-against-myocardial-ischemia-reperfusion-injury-via-suppressing-oxidative-nitrative-stress-and-inflammatory-response
#14
Zhaoxia Yu, Shaohua Wang, Xiangyang Zhang, Ying Li, Qiang Zhao, Tao Liu
Recent studies have shown that pterostilbene (Pte) confers protection against myocardial ischemia/reperfusion injury. The oxidative/nitrative stress and inflammation induce injury after myocardial ischemia/reperfusion. The present study was designed to evaluate whether treatment with Pte attenuates oxidative/nitrative stress and inflammation in myocardial ischemia/reperfusion (MI/R). Rats were subjected to 30min of myocardial ischemia and 3h of reperfusion, and the rats were administered with vehicle or Pte...
December 6, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27878500/anti-inflammatory-and-antioxidant-effect-of-kerabala-a-value-added-ayurvedic-formulation-from-virgin-coconut-oil-inhibits-pathogenesis-in-adjuvant-induced-arthritis
#15
M Ratheesh, S Sandya, C Pramod, S Asha, Jose P Svenia, S Premlal, B GrishKumar
Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-induced acute and adjuvant-induced chronic experimental models. 5 mg/kg bwt was found to be potent dose from carrageenan model and evaluated its effect in adjuvant-induced chronic arthritic model...
November 22, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27876107/sodium-butyrate-protects-mice-from-the-development-of-the-early-signs-of-non-alcoholic-fatty-liver-disease-role-of-melatonin-and-lipid-peroxidation
#16
Cheng Jun Jin, Anna Janina Engstler, Cathrin Sellmann, Doreen Ziegenhardt, Marianne Landmann, Giridhar Kanuri, Hakima Lounis, Markus Schröder, Walter Vetter, Ina Bergheim
Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide with universally accepted treatments still lacking. Oral supplementation of sodium butyrate (SoB) has been suggested to attenuate liver damage of various aetiologies. Our study aimed to further delineate mechanisms involved in the SoB-dependent hepatic protection using a mouse model of fructose-induced NAFLD and in in vitro models. C57BL/6J mice were either pair-fed a fructose-enriched liquid diet ±0·6 g/kg body weight per d SoB or standard chow for 6 weeks...
November 23, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27799756/reduction-of-neutrophilic-lung-inflammation-by-inhalation-of-the-compatible-solute-ectoine-a-randomized-trial-with-elderly-individuals
#17
Klaus Unfried, Ursula Krämer, Ulrich Sydlik, Andrea Autengruber, Andreas Bilstein, Sabine Stolz, Alessandra Marini, Tamara Schikowski, Stefanie Keymel, Jean Krutmann
BACKGROUND: Compatible solutes are natural substances that are known to stabilize cellular functions. Preliminary ex vivo and in vivo studies demonstrated that the compatible solute ectoine restores natural apoptosis rates of lung neutrophils and contributes to the resolution of lung inflammation. Due to the low toxicity and known compatibility of the substance, an inhalative application as an intervention strategy for humans suffering from diseases caused by neutrophilic inflammation, like COPD, had been suggested...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27796513/glucocorticosteroids
#18
Peter J Barnes
Glucocorticosteroids are the most effective anti-inflammatory therapy for asthma but are relatively ineffective in COPD. Glucocorticoids are broad-spectrum anti-inflammatory drugs that suppress inflammation via several molecular mechanisms. Glucocorticoids suppress the multiple inflammatory genes that are activated in asthma by reversing histone acetylation of activated inflammatory genes through binding of ligand-bound glucocorticoid receptors (GR) to coactivator molecules and recruitment of histone deacetylase-2 (HDAC2) to the activated inflammatory gene transcription complex (trans-repression)...
October 28, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27769022/tadalafil-reduces-airway-hyperactivity-and-protects-against-lung-and-respiratory-airways-dysfunction-in-a-rat-model-of-silicosis
#19
Rania R Abdelaziz, Wagdi F Elkashef, Eman Said
Silicosis is a crippling respiratory disorder characterized by massive lung inflammation and fibrosis. The current study provides evidence on the protective potential of tadalafil; a specific phosphodiesterase-5 (PDE-5) inhibitor against experimentally-induced pulmonary silicosis in rats. Silicosis was induced by intranasal instillation of crystalline silica (50mg/rat). Halofuginone hydrobromide; a standard collagen-1 synthesis inhibitor was selected as a reference anti-fibrotic. Daily oral administration of tadalafil (1mg/kg) for 8weeks significantly ameliorated silica-induced pulmonary damage...
November 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27757724/can-adiponectin-help-us-to-target-diastolic-dysfunction
#20
Catarina Francisco, João Sérgio Neves, Inês Falcão-Pires, Adelino Leite-Moreira
Adiponectin is the most abundant adipokine and exhibits anti-inflammatory, antiatherogenic and antidiabetic properties. Unlike other adipokines, it inversely correlates with body weight and obesity-linked cardiovascular complications. Diastolic dysfunction is the main mechanism responsible for approximately half of all heart failure cases, the so-called heart failure with preserved ejection fraction (HFpEF), but therapeutic strategies specifically directed towards these patients are still lacking. In the last years, a link between adiponectin and diastolic dysfunction has been suggested...
December 2016: Cardiovascular Drugs and Therapy
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