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https://www.readbyqxmd.com/read/29244203/pediatric-tolerogenic-dcs-expressing-cd4-and-immunoglobulin-like-transcript-receptor-ilt-4-secrete-il-10-in-response-to-fc-and-adenosine
#1
Alessandra Franco, Jeetendra Kumar, Gene Lin, Negar Behnamfar, Li-En Hisieh, Chisato Shimizu, Adriana H Tremoulet, Jane C Burns, Joel Linden
We characterized a novel population of tolerogenic myeloid dendritic cells (tmDCs) defined as CD11c+ CD11b+ CD14+ CD4+ and immunoglobulin-like transcript receptor (ILT)-4+ that are significantly more abundant in the circulation of infants and young children than in adults. TmDCs secrete the immunosuppressive lymphokine interleukin (IL)-10 when stimulated with the heavy constant region of immunoglobulins (Fc) and express high levels of the adenosine A2A receptor (A2A R), which, when activated by adenosine, inhibits the release of pro-inflammatory cytokines from most immune cells...
December 15, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29244074/the-heart-regulates-the-endocrine-response-to-heart-failure-cardiac-contribution-to-circulating-neprilysin
#2
Mattia Arrigo, Nicolas Vodovar, Hélène Nougué, Malha Sadoune, Chris J Pemberton, Pamela Ballan, Pierre-Olivier Ludes, Nicolas Gendron, Alain Carpentier, Bernard Cholley, Philippe Bizouarn, Alain Cohen-Solal, Jagmeet P Singh, Jackie Szymonifka, Christian Latremouille, Jane-Lise Samuel, Jean-Marie Launay, Julien Pottecher, A Mark Richards, Quynh A Truong, David M Smadja, Alexandre Mebazaa
Aims: Heart failure (HF) is accompanied by major neuroendocrine changes including the activation of the natriuretic peptide (NP) pathway. Using the unique model of patients undergoing implantation of the CARMAT total artificial heart and investigating regional differences in soluble neprilysin (sNEP) in patients with reduced or preserved systolic function, we studied the regulation of the NP pathway in HF. Methods and results: Venous blood samples from two patients undergoing replacement of the failing ventricles with a total artificial heart were collected before implantation and weekly thereafter until post-operative week 6...
December 13, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29243308/western-herbal-medicine-consultations-for-common-menstrual-problems-practitioner-experiences-and-perceptions-of-treatment
#3
Carole Fisher, Jon Adams, Jane Frawley, Louise Hickman, David Sibbritt
To explore the prevalence with which Australian Western herbalists treat menstrual problems and their related treatment, experiences, perceptions, and interreferral practices with other health practitioners. Members of the Practitioner Research and Collaboration Initiative practice-based research network identifying as Western Herbalists (WHs) completed a specifically developed, online questionnaire. Western Herbalists regularly treat menstrual problems, perceiving high, though differential, levels of effectiveness...
December 15, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29243176/understanding-and-reducing-complex-systems-pharmacology-models-based-on-a-novel-input-response-index
#4
Jane Knöchel, Charlotte Kloft, Wilhelm Huisinga
A growing understanding of complex processes in biology has led to large-scale mechanistic models of pharmacologically relevant processes. These models are increasingly used to study the response of the system to a given input or stimulus, e.g., after drug administration. Understanding the input-response relationship, however, is often a challenging task due to the complexity of the interactions between its constituents as well as the size of the models. An approach that quantifies the importance of the different constituents for a given input-output relationship and allows to reduce the dynamics to its essential features is therefore highly desirable...
December 14, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/29242584/mis-expression-of-grainyhead-like-transcription-factors-in-zebrafish-leads-to-defects-in-enveloping-layer-evl-integrity-cellular-morphogenesis-and-axial-extension
#5
Lee B Miles, Charbel Darido, Jan Kaslin, Joan K Heath, Stephen M Jane, Sebastian Dworkin
The grainyhead-like (grhl) transcription factors play crucial roles in craniofacial development, epithelial morphogenesis, neural tube closure, and dorso-ventral patterning. By utilising the zebrafish to differentially regulate expression of family members grhl2b and grhl3, we show that both genes regulate epithelial migration, particularly convergence-extension (CE) type movements, during embryogenesis. Genetic deletion of grhl3 via CRISPR/Cas9 results in failure to complete epiboly and pre-gastrulation embryonic rupture, whereas morpholino (MO)-mediated knockdown of grhl3 signalling leads to aberrant neural tube morphogenesis at the midbrain-hindbrain boundary (MHB), a phenotype likely due to a compromised overlying enveloping layer (EVL)...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29242095/cochrane-qualitative-and-implementation-methods-group-guidance-paper-4-methods-for-integrating-qualitative-and-implementation-evidence-within-intervention-effectiveness-reviews
#6
Angela Harden, James Thomas, Margaret Cargo, Janet Harris, Tomas Pantoja, Kate Flemming, Andrew Booth, Ruth Garside, Karin Hannes, Jane Noyes
The Cochrane Qualitative and Implementation Methods Group (CQIMG) develops and publishes guidance on the synthesis of qualitative and mixed-method evidence from process evaluations. Despite a proliferation of methods for the synthesis of qualitative research, less attention has focused on how to integrate these syntheses within intervention effectiveness reviews. In this paper we report updated guidance from the group on approaches, methods and tools which can be used to integrate the findings from quantitative studies evaluating intervention effectiveness with those from qualitative studies and process evaluations...
December 11, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29242094/cochrane-qualitative-and-implementation-methods-group-guidance-series-paper-1-introduction
#7
Jane Noyes, Andrew Booth, Margaret Cargo, Kate Flemming, Ruth Garside, Karin Hannes, Angela Harden, Janet Harris, Simon Lewin, Tomas Pantoja, James Thomas
No abstract text is available yet for this article.
December 11, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29241795/romance-love-and-sex-in-the-dermatology-department-and-residency-program
#8
Lionel Bercovitch, Jane M Grant-Kels
No abstract text is available yet for this article.
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29241794/drug-associated-hidradenitis-suppurativa-a-systematic-review-of-case-reports
#9
John W Frew, Dunja A Vekic, Jane A Woods, Geoffrey D Cains
No abstract text is available yet for this article.
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29241589/corrigendum-to-acknowledging-attributes-that-enable-the-career-academic-nurse-to-thrive-in-the-tertiary-education-sector-a-qualitative-systematic-review-nurse-educ-today-45-october-2016-212-218
#10
Aileen Wyllie, Michelle DiGiacomo, Debra Jackson, Patricia Davidson, Jane Phillips
No abstract text is available yet for this article.
December 11, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29240739/office-design-and-health-a-systematic-review
#11
Ann Richardson, John Potter, Margaret Paterson, Thomas Harding, Gaye Tyler-Merrick, Ray Kirk, Kate Reid, Jane McChesney
AIM: To carry out a systematic review of recent research into the effects of workplace design, comparing individual with shared workspaces, on the health of employees. METHODS: The research question was "Does workplace design (specifically individual offices compared with shared workspaces) affect the health of workers?" A literature search limited to articles published between 2000 and 2017 was undertaken. A systematic review was carried out, and the findings of the reviewed studies grouped into themes according to the primary outcomes measured in the studies...
December 15, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29240299/the-effect-of-haemopoietic-stem-cell-transplantation-on-the-ocular-phenotype-in-mucopolysaccharidosis-type-i-hurler
#12
Ahmed Javed, Tariq Aslam, Simon A Jones, Jean Mercer, Karen Tyler, Heather Church, Arunabha Ghosh, Robert Wynn, Krishanthy Sornalingam, Jane Ashworth
PURPOSE: To determine whether the ocular phenotype in patients with mucopolysaccharidosis type I (MPSI) Hurler is affected by the efficacy of previous haemopoietic stem cell transplantation (HSCT). DESIGN: A retrospective cohort study of patients with MPSI who had undergone treatment with HSCT. METHODS: Ocular phenotype was documented for each patient and compared to levels of biomarkers representing efficacy of previous transplantation. MAIN OUTCOME MEASURES: Assessment of visual acuity (VA), severity of corneal clouding and the presence of optic neuropathy or retinopathy...
December 14, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29240261/mitochondrial-dysfunction-rad51-and-ku80-proteolysis-promote-apoptotic-effects-of-dinaciclib-in-bcl-xl-silenced-cells
#13
Daniel R Premkumar, Esther P Jane, Swetha Thambireddy, Philip A Sutera, Jonathon M Cavaleri, Ian F Pollack
In the present study, we investigated the effect of CDK inhibitors (ribociclib, palbociclib, seliciclib, AZD5438 and dinaciclib) on malignant human glioma cells for cell viability, apoptosis, oxidative stress and mitochondrial function using various assays. None of the CDK inhibitors induced cell death at a clinically relevant concentration. However, low nanomolar concentrations of dinaciclib showed higher cytotoxic activity against Bcl-xL silenced cells in a time- and concentration-dependent manner. This effect was not seen with other CDK inhibitors...
December 14, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29239666/highly-selective-and-sensitive-measurement-of-active-forms-of-fgf21-using-novel-immunocapture-enrichment-with-lc-ms-ms
#14
Yue Zhao, Guowen Liu, Suk Kwok, Barry R Jones, Jane Liu, David Marchisin, Philip E Joyce, Jon Peterson, Jim X Shen
AIM: Recombinant FGF21 analogs are under wide ranging investigations as a potential therapeutic agent for Type 2 diabetes, as well as other metabolic disorders. The endogenous FGF21 is often used as a surrogate pharmacodynamic(PD) biomarker to assess drug efficacy and safety. Results/methodology: Immunocapture was performed using a monoclonal antibody which had been generated to bind to specific domain of native FGF21 as the capture reagent. After immunocapture, enzymatic digestion was performed and a native FGF21-specific tryptic peptide was monitored using LC-MS/MS by selective reaction monitoring...
December 14, 2017: Bioanalysis
https://www.readbyqxmd.com/read/29238608/study-protocol-for-enhancing-parenting-in-cancer-epic-development-and-evaluation-of-a-brief-psycho-educational-intervention-to-support-parents-with-cancer-who-have-young-children
#15
Lesley Stafford, Michelle Sinclair, Jane Turner, Louise Newman, Claire Wakefield, Mei Krishnasamy, G Bruce Mann, Leslie Gilham, Kylie Mason, Paula Rauch, Julia Cannell, Penelope Schofield
Background: Parents with cancer have high rates of psychological morbidity, and their children are at risk of poor psychosocial outcomes, particularly in the context of parental distress and poor family communication. Parents express concerns about the impact of cancer on their children and report a lack of professional guidance in meeting their children's needs. Few parenting interventions exist and current interventions have extensive infrastructure demands making them unsuitable for routine use in most health settings...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29238268/the-mental-health-and-substance-misuse-needs-of-male-ex-armed-forces-personnel-in-prison
#16
Verity Wainwright, Charlotte Lennox, Sharon McDonnell, Jenny Shaw, Jane Senior
Ex-armed forces personnel constitute the largest known occupational group in prison but there is little evidence regarding their mental health, or substance misuse, needs. A total of 105 participants were interviewed and measures assessing symptoms of common mental health (CMH) problems and substance misuse were completed along with a review of their health care records. Forty (38%) participants screened for current CMH problems (CCMH) and high levels of dual symptomology and alcohol misuse were assessed. Thirty-nine (37%) had a mental health diagnosis recorded, most commonly for post-traumatic stress disorder (PTSD), depression and personality disorder...
2018: Journal of Forensic Psychiatry & Psychology
https://www.readbyqxmd.com/read/29238073/stage-dependent-therapeutic-efficacy-in-pi3k-mtor-driven-squamous-cell-carcinoma-of-the-skin
#17
Charbel Darido, Smitha R Georgy, Carleen Cullinane, Darren D Partridge, Rachael Walker, Seema Srivastava, Suraya Roslan, Marina R Carpinelli, Sebastian Dworkin, Richard B Pearson, Stephen M Jane
Cutaneous squamous cell carcinoma (SCC) is a recurrent cancer that is prevalent in predisposed subjects such as immunosuppressed patients and patients being treated for other malignancies. Model systems to trial therapies at different stages of SCC development are lacking, therefore precluding efficient therapeutic interventions. Here, we have disrupted the expression of the tumor suppressor GRHL3 to induce loss of PTEN and activation of the PI3K/mTOR signaling pathway in mice and human skin, promoting aggressive SCC development...
December 13, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29237801/adolescent-loss-of-control-eating-and-weight-loss-maintenance-after-bariatric-surgery
#18
Andrea B Goldschmidt, Jane Khoury, Todd M Jenkins, Dale S Bond, J Graham Thomas, Linsey M Utzinger, Meg H Zeller, Thomas H Inge, James E Mitchell
BACKGROUND: Loss-of-control (LOC) eating is common in adults undergoing bariatric surgery and is associated with poorer weight outcomes. Its long-term course in adolescent bariatric surgery patients and associations with weight outcomes are unclear. METHODS: Adolescents (n = 234; age range = 13-19 years) undergoing bariatric surgery across 5 US sites were assessed for postsurgery follow-up at 6 months and 1, 2, 3, and 4 years. Descriptive statistics and generalized linear mixed models were used to describe the prevalence of LOC eating episodes involving objectively large amounts of food and continuous eating, respectively...
December 13, 2017: Pediatrics
https://www.readbyqxmd.com/read/29237744/change-in-cognitive-function-in-the-month-after-hospitalization-for-acute-coronary-syndromes-findings-from-trace-core-transition-risks-and-actions-in-coronary-events-center-for-outcomes-research-and-education
#19
Jane S Saczynski, David D McManus, Molly E Waring, Darleen Lessard, Milena D Anatchkova, Jerry H Gurwitz, Jeroan Allison, Arlene S Ash, Richard H McManus, David C Parish, Robert J Goldberg, Catarina I Kiefe
BACKGROUND: Cognitive function is often impaired during hospitalization, but whether this impairment resolves or persists after discharge is unknown. METHODS AND RESULTS: We enrolled (April 2011-May 2013) and interviewed during hospitalization and 1-month post-discharge 1521 nondemented acute coronary syndrome survivors enrolled in TRACE (Transitions, Risks and Actions in Coronary Events). Cognitive function was assessed using the Telephone Interview of Cognitive Status (range: 0-41) at both time points...
December 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29237603/in-bed-with-siri-and-google-assistant-a-comparison-of-sexual-health-advice
#20
Nick Wilson, E Jane MacDonald, Osman David Mansoor, Jane Morgan
No abstract text is available yet for this article.
December 13, 2017: BMJ: British Medical Journal
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