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https://www.readbyqxmd.com/read/29909402/impact-of-exercise-restriction-on-arrhythmic-risk-among-patients-with-arrhythmogenic-right-ventricular-cardiomyopathy
#1
Weijia Wang, Gabriela Orgeron, Crystal Tichnell, Brittney Murray, Jane Crosson, Oliver Monfredi, Julia Cadrin-Tourigny, Harikrishna Tandri, Hugh Calkins, Cynthia A James
BACKGROUND: Prior studies have shown a close link between exercise and development of arrhythmogenic right ventricular cardiomyopathy. How much exercise restriction reduces ventricular arrhythmia (VA), how genotype modifies its benefit, and whether it reduces risk sufficiently to defer implantable cardioverter-defibrillator (ICD) placement in arrhythmogenic right ventricular cardiomyopathy are unknown. METHODS AND RESULTS: We interviewed 129 arrhythmogenic right ventricular cardiomyopathy patients (age: 34...
June 16, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29909032/spray-drying-and-extrusion-processes-effects-on-morphology-and-physicochemical-characteristics-of-starches-isolated-from-peruvian-carrot-and-cassava
#2
Thais Paes Rodrigues Dos Santos, Célia Maria Landi Franco, Ivo Mottin Demiate, Xue-Hong Li, Emerson Loli Garcia, Jay-Lin Jane, Magali Leonel
No abstract text is available yet for this article.
June 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29908826/intramyocardial-autologous-cd34-cell-therapy-for-refractory-angina-a-meta-analysis-of-randomized-controlled-trials
#3
Poonam Velagapudi, Mohit Turagam, Dhaval Kolte, Sahil Khera, Omar Hyder, Paul Gordon, Herbert D Aronow, Jane Leopold, J Dawn Abbott
BACKGROUND: Previous studies have demonstrated that intramyocardial human CD34+ cells may relieve symptoms and improve clinical outcomes in chronic refractory angina unresponsive to optimal medical therapy or not amenable to revascularization. METHODS: We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the impact of human CD34+ cells compared with placebo in chronic refractory angina. Primary efficacy outcomes in our analysis were angina frequency and exercise time...
June 5, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29908484/ethnic-differences-in-the-diagnosis-of-schizophrenia-and-mood-disorders-during-admission-to-an-academic-safety-net-psychiatric-hospital
#4
Jane E Hamilton, Angela M Heads, Thomas D Meyer, Pratikkumar V Desai, Olaoluwa O Okusaga, Raymond Y Cho
U.S. Hispanics, now the single largest minority group in the country, face unique mental health disparities. The current study utilizes Andersen's Behavioral Model of Health Service Use to examine ethnic disparities in receiving a schizophrenia or mood disorder diagnosis at psychiatric hospital admission. Our retrospective cohort study examined electronic health record data at an academic safety-net psychiatric hospital for adult patients (n = 5571) admitted between 2010 and 2013. Logistic regression with block-wise entry of predisposing, enabling and need variables was used to examine ethnic disparities in receiving a schizophrenia diagnosis at admission...
May 30, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29908304/pathway-based-predictive-approaches-for-non-animal-assessment-of-acute-inhalation-toxicity
#5
REVIEW
Amy J Clippinger, David Allen, Holger Behrsing, Kelly A BéruBé, Michael B Bolger, Warren Casey, Michael DeLorme, Marianna Gaça, Sean C Gehen, Kyle Glover, Patrick Hayden, Paul Hinderliter, Jon A Hotchkiss, Anita Iskandar, Brian Keyser, Karsta Luettich, Lan Ma-Hock, Anna G Maione, Patrudu Makena, Jodie Melbourne, Lawrence Milchak, Sheung P Ng, Alicia Paini, Kathryn Page, Grace Patlewicz, Pilar Prieto, Hans Raabe, Emily N Reinke, Clive Roper, Jane Rose, Monita Sharma, Wayne Spoo, Peter S Thorne, Daniel M Wilson, Annie M Jarabek
New approaches are needed to assess the effects of inhaled substances on human health. These approaches will be based on mechanisms of toxicity, an understanding of dosimetry, and the use of in silico modeling and in vitro test methods. In order to accelerate wider implementation of such approaches, development of adverse outcome pathways (AOPs) can help identify and address gaps in our understanding of relevant parameters for model input and mechanisms, and optimize non-animal approaches that can be used to investigate key events of toxicity...
June 13, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29908181/ppar-gamma-pathways-attenuate-pulmonary-granuloma-formation-in-a-carbon-nanotube-induced-murine-model-of-sarcoidosis
#6
Matthew McPeek, Anagha Malur, Debra A Tokarz, Gina Murray, Barbara P Barna, Mary Jane Thomassen
Peroxisome proliferator activated receptor gamma (PPARγ), a ligand activated nuclear transcription factor, is constitutively expressed in alveolar macrophages of healthy individuals. PPARγ deficiencies have been noted in several lung diseases including the alveolar macrophages of pulmonary sarcoidosis patients. We have previously described a murine model of multiwall carbon nanotube (MWCNT) induced pulmonary granulomatous inflammation which bears striking similarities to pulmonary sarcoidosis, including the deficiency of alveolar macrophage PPARγ...
June 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29908071/total-flucloxacillin-plasma-concentrations-poorly-reflect-unbound-concentrations-in-hospitalised-patients-with-staphylococcus-aureus-bacteraemia
#7
Paul Ken Leong Chin, Philip George Drennan, Sharon Jane Gardiner, Mei Zhang, Simon Charles Dalton, Stephen T Chambers, Evan James Begg
BACKGROUND: Flucloxacillin dosing may be guided by measurement of its total plasma concentrations. Flucloxacillin is highly protein bound with fraction unbound in plasma (fu ) of around 0.04 in healthy individuals. The utility of measuring unbound flucloxacillin concentrations for patients outside the intensive care unit (ICU) is not established. AIMS: To compare flucloxacillin fu in non-ICU hospitalised patients against healthy volunteers. To examine the performance of a published model for predicting unbound concentrations, using total flucloxacillin and plasma albumin concentrations...
June 16, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29908041/automated-quantification-of-microvascular-perfusion
#8
P Mason McClatchey, Nicholas A Mignemi, Zhengang Xu, Ian M Williams, Jane E B Reusch, Owen P McGuinness, David H Wasserman
OBJECTIVE: Changes in microvascular perfusion have been reported in many diseases, yet the functional significance of altered perfusion is often difficult to determine. This is partly because commonly used techniques for perfusion measurement often rely on either indirect or by-hand approaches. METHODS: We developed and validated a fully automated software technique to measure microvascular perfusion in videos acquired by fluorescence microscopy in the mouse gastrocnemius...
June 16, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/29907942/distribution-of-21-gene-recurrence-scores-in-male-breast-cancer-in-the-united-states
#9
Ariella M Altman, Scott Kizy, Jianling Yuan, Jason W Denbo, Eric H Jensen, Jane Y C Hui, Todd M Tuttle, Schelomo Marmor
BACKGROUND: The 21-gene recurrence score (RS) is a RT-PCR assay estimating risk of distant recurrence in estrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2) breast cancer (BC). Studies validating RS are limited to women. Our objective was to assess RS distribution and factors associated with high-risk RS in male BC. METHODS: Using the Surveillance, Epidemiology, and End Results database, we identified men and women with ER+/HER2- BC from 2010 to 2013...
June 15, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29907679/the-tumour-suppressor-opcml-promotes-axl-inactivation-by-the-phosphatase-ptprg-in-ovarian-cancer
#10
Jane Antony, Elisa Zanini, Zoe Kelly, Tuan Zea Tan, Evdoxia Karali, Mohammad Alomary, Youngrock Jung, Katherine Nixon, Paula Cunnea, Christina Fotopoulou, Andrew Paterson, Sushmita Roy-Nawathe, Gordon B Mills, Ruby Yun-Ju Huang, Jean Paul Thiery, Hani Gabra, Chiara Recchi
In ovarian cancer, the prometastatic RTK AXL promotes motility, invasion and poor prognosis. Here, we show that reduced survival caused by AXL overexpression can be mitigated by the expression of the GPI-anchored tumour suppressor OPCML Further, we demonstrate that AXL directly interacts with OPCML, preferentially so when AXL is activated by its ligand Gas6. As a consequence, AXL accumulates in cholesterol-rich lipid domains, where OPCML resides. Here, phospho-AXL is brought in proximity to the lipid domain-restricted phosphatase PTPRG, which de-phosphorylates the RTK/ligand complex...
June 15, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29907583/fifteen-minute-consultation-modern-day-art-and-science-of-managing-cerebral-palsy
#11
Jill Cadwgan, Jane Goodwin, Charlie Fairhurst
While there remains limited intervention to address the damage to the developing brain, current multidisciplinary management of cerebral palsy (CP) needs to minimise the impact of secondary musculoskeletal complications. A focus on comorbidities to maximise function for activity and participation by supporting the child and family in their environment is required. Comprehensive clinical guidance was published by National Institute for Health and Care Excellence (NICE) earlier this year. This article aims to provide a practical clinical approach to the child and family based on:(1) art: empathy, listening and weighing up the clinical picture of the child and family in context; diagnosis, the need for support and space; and care coordination at the right time; and (2) science: the current science in CP care is rapidly expanding in terms of plasticity, pathophysiology, functional assessments and treatments...
June 15, 2018: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/29906785/dominant-intraprostatic-cancer-confirmed-by-direct-mri-guided-biopsy-concordance-with-histopathological-findings
#12
Nicholas P Meermeier, Kevin R Turner, Bryan R Foster, Csanád Várallyay, Jen-Jane Liu, Fergus V Coakley
PURPOSE: To investigate the concordance between dominant intraprostatic cancer seen on endorectal multiparametric MRI and confirmed by MRI-targeted biopsy with histopathological findings at radical prostatectomy, since existing literature has emphasized the miss rather than the concordance rate of MRI. MATERIALS AND METHODS: We retrospectively identified 20 patients who underwent radical prostatectomy after a dominant intraprostatic cancer focus was identified at endorectal multiparametric MRI and confirmed by MRI-targeted biopsy...
June 9, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29906604/barcoding-and-multi-locus-phylogeography-of-the-globally-distributed-calcareous-tubeworm-genus-hydroides-gunnerus-1768-annelida-polychaeta-serpulidae
#13
Yanan Sun, Eunice Wong, Shane T Ahyong, Jane E Williamson, Pat A Hutchings, Elena K Kupriyanova
Hydroides is a large and diverse group of calcareous tubeworms (Serpulidae, Annelida) recognised by a distinctive but variable two-tiered operculum. Despite considerable research using several species of Hydroides as models in ecological and biofouling studies, phylogenetic and biogeographic relationships within the genus are still poorly understood. Using combined mitochondrial (COI, cytochrome b) and nuclear (18S, 28S and ITS) gene markers for 284 individuals of 45 morphospecies of Hydroides, we investigated the global phylogenetic and biogeographic relationships within the genus...
June 12, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29906589/overexpression-of-adeabc-efflux-pump-associated-with-tigecycline-resistance-in-clinical-acinetobacter-nosocomialis-isolates
#14
Ya-Sung Yang, Hsing-Yu Chen, Wei-Jane Hsu, Yu-Ching Chou, Cherng-Lih Perng, Hung-Sheng Shang, Yuan-Ting Hsiao, Jun-Ren Sun
OBJECTIVES: Tigecycline non-susceptible Acinetobacter nosocomialis (TNAN) have been discovered in clinical isolates. The resistance-nodulation-cell division (RND)-type efflux system plays a major role in tigecycline non-susceptible of Acinetobacter baumannii, but the mechanism in Acinetobacter nosocomialis remains unknown. Our aim was to analyze the contribution of efflux based tigecycline resistance in clinical A. nosocomialis isolates collected from multiple medical centers in Taiwan...
June 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29906545/the-ethical-issue-of-cherry-picking-patients
#15
Travis J Morrell, Sailesh Konda, Jane M Grant-Kels
No abstract text is available yet for this article.
June 12, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29906513/adolescent-parent-dyadic-retention-in-an-interview-study-and-changes-in-willingness-to-participate-in-a-hypothetical-microbicide-safety-study
#16
Jenny K R Francis, Ariel M de Roche, Christine Mauro, Sara E Landers, Jane Chang, Marina Catallozzi, Carmen Radecki Breitkopf, Susan L Rosenthal
STUDY OBJECTIVE: The study describes adolescent and parent retention and changes in willingness to participate (WTP) in research among adolescents, parents, and adolescent-parent dyads. DESIGN AND SETTING: Adolescent-parent dyads were recruited to participate in a longitudinal study to assess research participation attitudes using simultaneous individual interviews of the adolescent and parent with a return visit one year later using the same interview. PARTICIPANTS: Adolescents (14-17 years old) and their parents...
June 12, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29905516/volcanic-eruptions-and-threats-to-respiratory-health
#17
W Graham Carlos, Jane E Gross, Shazia Jamil, Charles S Dela Cruz, David Damby, Elizabeth Tam
No abstract text is available yet for this article.
June 15, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29905377/red-blood-cell-adhesion-to-heme-activated-endothelial-cells-reflects-clinical-phenotype-in-sickle-cell-disease
#18
Erdem Kucukal, Anton Ilich, Nigel S Key, Jane A Little, Umut A Gurkan
In sickle cell disease (SCD), 'disease severity' associates with increased RBC adhesion to quiescent endothelium, but the impact on activated endothelium is not known. Increased concentrations of free heme result from intravascular hemolysis in SCD. Heme is essential for aerobic metabolism, and plays an important role in numerous biological processes. Excess free heme induces reactive oxygen species generation and endothelial activation, which are associated with cardiovascular disorders including atherosclerosis, hypertension, and thrombosis...
June 15, 2018: American Journal of Hematology
https://www.readbyqxmd.com/read/29904935/physical-activity-and-the-risk-of-colorectal-cancer-in-lynch-syndrome
#19
S Ghazaleh Dashti, Aung Ko Win, Sheetal S Hardikar, Stephen E Glombicki, Sheila Mallenahalli, Selvi Thirumurthi, Susan K Peterson, Y Nancy You, Daniel D Buchanan, Jane C Figueiredo, Peter T Campbell, Steven Gallinger, Polly A Newcomb, John D Potter, Noralane M Lindor, Loic Le Marchand, Robert W Haile, John L Hopper, Mark A Jenkins, Karen M Basen-Engquist, Patrick M Lynch, Mala Pande
Greater physical activity is associated with a decrease in risk of colorectal cancer for the general population; however, little is known about its relationship with colorectal cancer risk for people with Lynch syndrome, carriers of inherited pathogenic mutations in genes affecting DNA mismatch repair (MMR). We studied a cohort of 2,042 MMR gene mutations carriers (n=807, diagnosed with colorectal cancer), from the Colon Cancer Family Registry. Self-reported physical activity in three age-periods (20-29, 30-49, and ≥50 years) was summarized as average metabolic equivalent of task hours per week (MET-h/week) during the age-period of cancer diagnosis or censoring (near-term exposure), and across all age-periods preceding cancer diagnosis or censoring (long-term exposure)...
June 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29904733/koebner-phenomenon-consideration-when-choosing-fractionation-for-breast-irradiation
#20
Cheng-Chia Wu, Shutao Wang, Jane J An, Deborah R Smith, Christine Chin, Priya H Jadeja, Eileen P Connolly, David P Horowitz
No abstract text is available yet for this article.
April 2018: Advances in Radiation Oncology
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