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https://www.readbyqxmd.com/read/29684837/patient-safety-content-and-delivery-in-pre-registration-nursing-curricula-a-national-cross-sectional-survey-study
#1
Kim Usher, Cindy Woods, Jane Conway, Jackie Lea, Vicki Parker, Fiona Barrett, Eilish O'Shea, Debra Jackson
BACKGROUND: Patient safety is a core principle of health professional practice and as such requires significant attention within undergraduate curricula. However, patient safety practice is complex requiring a broad range of skills and behaviours including the application of sound clinical knowledge within a range of health care contexts and cultures. There is very little research that explores how this is taught within Australian nursing curricula. OBJECTIVES: To examine how Australian nursing curricula address patient safety; identify where and how patient safety learning occurs; and describe who is responsible for facilitating this learning...
April 17, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29684796/-they-told-me-all-mothers-have-worries-stillborn-mother-s-experiences-of-having-a-gut-instinct-that-something-is-wrong-in-pregnancy-findings-from-an-international-case-control-study
#2
Jane Warland, Alexander E P Heazell, Tomasina Stacey, Christin Coomarasamy, Jayne Budd, Edwin A Mitchell, Louise M O'Brien
OBJECTIVE: To describe and explore 'gut instinct' that something was wrong in women who identified that they experienced gut instinct during pregnancy. METHOD: A case-control study utilising an international web-based questionnaire. Stillborn cases (n = 146) and liveborn controls (n = 234) answered the gut instinct question within 30 days of the pregnancy ending. Of those, 84 cases and 27 controls also provided qualitative comment data. Descriptive statistics were used for the question, with a fixed option and summative content analysis was used to analyse the comment data...
April 11, 2018: Midwifery
https://www.readbyqxmd.com/read/29684794/changes-in-maternal-self-efficacy-postnatal-depression-symptoms-and-social-support-among-chinese-primiparous-women-during-the-initial-postpartum-period-a-longitudinal-study
#3
Xujuan Zheng, Jane Morrell, Kim Watts
BACKGROUND: There are many parenting problems during infancy for Chinese primiparous women. As an important determinant of good parenting, maternal self-efficacy (MSE) should be paid more attention by researchers. At present, the limitations of previous research examining MSE during infancy are that most studies were conducted with a homogeneous sample and there were few studies with Chinese women. Secondly, the trajectory of change in MSE, postnatal depression symptoms and social support for Chinese primiparous women was not clear during the initial postpartum period in earlier studies...
April 11, 2018: Midwifery
https://www.readbyqxmd.com/read/29684651/the-geography-of-smallpox-in-england-before-vaccination-a-conundrum-resolved
#4
Romola Jane Davenport, Max Satchell, Leigh Matthew William Shaw-Taylor
Smallpox is regarded as an ancient and lethal disease of humans, however very little is known about the prevalence and impact of smallpox before the advent of vaccination (c.1800). Here we use evidence from English burial records covering the period 1650-1799 to confirm a striking geography to smallpox patterns. Smallpox apparently circulated as a childhood disease in northern England and Sweden, even where population densities were low and settlement patterns dispersed. However, smallpox was a relatively rare epidemic disease in southern England outside the largest cities, despite its commercialised economy and the growing spatial interconnectedness of its settlements...
April 16, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29684405/moderate-perinatal-thyroid-hormone-insufficiency-alters-visual-system-function-in-adult-rats
#5
William K Boyes, Laura Degn, Barbara Jane George, Mary E Gilbert
Thyroid hormone (TH) is critical for many aspects of neurodevelopment and can be disrupted by a variety of environmental contaminants. Sensory systems, including audition and vision are vulnerable to TH insufficiencies, but little data are available on visual system development at less than severe levels of TH deprivation. The goal of the current experiments was to explore dose-response relations between graded levels of TH insufficiency during development and the visual function of adult offspring. Pregnant Long Evans rats received 0 or 3 ppm (Experiment 1), or 0, 1, 2, or 3 ppm (Experiment 2) of propylthiouracil (PTU), an inhibitor of thyroid hormone synthesis, in drinking water from gestation day (GD) 6 to postnatal day (PN) 21...
April 20, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29684237/frailty-phenotype-and-healthcare-costs-and-utilization-in-older-women
#6
Kristine E Ensrud, Allyson M Kats, John T Schousboe, Brent C Taylor, Peggy M Cawthon, Teresa A Hillier, Kristine Yaffe, Steve R Cummings, Jane A Cauley, Lisa Langsetmo
OBJECTIVES: To determine the association of the frailty phenotype with subsequent healthcare costs and utilization. DESIGN: Prospective cohort study (Study of Osteoporotic Fractures (SOF)). SETTING: Four U.S. sites. PARTICIPANTS: Community-dwelling women (mean age 80.2) participating in SOF Year 10 (Y10) examination linked with their Medicare claims data (N=2,150). MEASUREMENTS: At Y10, frailty phenotype defined using criteria similar to those used in the Cardiovascular Health Study frailty phenotype and categorized as robust, intermediate stage, or frail...
April 23, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29684211/heterotypic-infection-and-spread-of-rhinovirus-a-b-and-c-among-child-care-attendees
#7
Emily T Martin, Jane Kuypers, Helen Y Chu, Sydney Foote, Andrew Hashikawa, Mary P Fairchok, Janet A Englund
Background: Despite the frequency of human rhinovirus (HRV), data describing the molecular epidemiology of HRV in the community are limited. Child care centers are optimal settings to characterize heterotypic HRV co-circulation. Methods: HRV specimens were prospectively obtained from a cohort of child care attendees at enrollment and weekly during respiratory illness. Sequences of the 5' non-coding region were used to determine HRV species (A, B, or C) and genotypes...
April 19, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29684128/understanding-australian-policies-on-public-health-using-social-and-political-science-theories-reflections-from-an-academy-of-the-social-sciences-in-australia-workshop
#8
Fran Baum, Adam Graycar, Toni Delany-Crowe, Evelyne de Leeuw, Carol Bacchi, Jennie Popay, Lionel Orchard, Hal Colebatch, Sharon Friel, Colin MacDougall, Elizabeth Harris, Angela Lawless, Dennis McDermott, Matthew Fisher, Patrick Harris, Clare Phillips, Jane Fitzgerald
There is strong, and growing, evidence documenting health inequities across the world. However, most governments do not prioritize policies to encourage action on the social determinants of health and health equity. Furthermore, despite evidence concerning the benefits of joined-up, intersectoral policy to promote health and health equity, it is rare for such policy approaches to be applied systematically. To examine the usefulness of political and social science theory in understanding the reasons for this disjuncture between evidence and practice, researchers and public servants gathered in Adelaide for an Academy of the Social Sciences in Australia (ASSA) Workshop...
April 19, 2018: Health Promotion International
https://www.readbyqxmd.com/read/29683659/the-identification-of-potent-selective-and-orally-available-inhibitors-of-ataxia-telangiectasia-mutated-atm-kinase-the-discovery-of-azd0156-8-6-3-dimethylamino-propoxy-pyridin-3-yl-3-methyl-1-tetrahydro-2h-pyran-4-yl-1-3-dihydro-2h-imidazo-4-5-c-quinolin-2
#9
Kurt G Pike, Bernard Barlaam, Elaine Cadogan, Andrew Campbell, Yingxue Chen, Nicola Colclough, Nichola L Davies, Camila DeAlmeida, Sébastien L Degorce, Myriam Didelot, Allan Dishington, Richard Ducray, Stephen T Durant, Lorraine A Hassall, Jane L Holmes, Gareth D Hughes, Philip A MacFaul, Keith R Mulholland, Thomas M McGuire, Gilles Ouvry, Martin Pass, Graeme R Robb, Natalie Stratton, Zhenhua Wang, Joanne Wilson, Baochang Zhai, Kang Zhao, Nidal Al-Huniti
ATM inhibitors, such as 7, have demonstrated the anti-tumor potential of ATM inhibition when combined with DNA double strand break-inducing agents in mouse xenograft models. However, the properties of 7 result in a relatively high predicted clinically efficacious dose. In an attempt to minimize attrition during clinical development we sought to identify ATM inhibitors with a low predicted clinical dose (<50 mg) and focussed on strategies to increase both ATM potency and predicted human pharmacokinetic half-life (predominantly through the increase of volume of distribution)...
April 23, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29683292/dermatitis-artefacta-in-childhood-and-adolesence-a-spectrum-of-disease
#10
Padma Mohandas, Jane Ravenscroft, Anthony Bewley
Dermatitis Artefacta (DA) or Artefactual skin disease (ASD) is a factitious skin disorder rarely reported in the paediatric population. Skin lesions are produced deliberately either consciously or in a dissociative state to satisfy an underlying psychological need. Children may present with acutely formed skin changes or with chronic lesions, quite often having seen other specialists during their journey. The mechanism of formation of skin lesions can vary from the application of pigment onto the skin to simulate disease or more destructive techniques like the injection of irritant substances into the skin...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29683222/ascl1-regulates-proliferation-of-ng2-glia-in-the-embryonic-and-adult-spinal-cord
#11
Demetra P Kelenis, Emma Hart, Morgan Edwards-Fligner, Jane E Johnson, Tou Yia Vue
NG2-glia are highly proliferative oligodendrocyte precursor cells (OPCs) that are widely distributed throughout the central nervous system (CNS). During development, NG2-glia predominantly differentiate into oligodendrocytes (OLs) to myelinate axon fibers, but they can also remain as OPCs persisting into the mature CNS. Interestingly, NG2-glia in the gray matter (GM) are intrinsically different from those in the white matter (WM) in terms of proliferation, differentiation, gene expression, and electrophysiological properties...
April 23, 2018: Glia
https://www.readbyqxmd.com/read/29683118/searching-for-simplicity-in-the-complexity-of-symptom-clusters
#12
Lanell M Bellury, Jane C Clark
Occam's razor proposes that the simplest solution is preferable; however, in the science of cancer and cancer symptoms, simple solutions have been elusive. Understanding individual symptoms continues to confound the science community, and symptom cluster science appears to be an incredibly complex schema of individual symptoms co-occurring and interacting with one another. The simplest explanation for symptom clusters would be a common underlying mechanism at the human genome level. Such a finding could greatly simplify and perhaps revolutionize symptom management...
May 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29682559/hemodynamic-instability-during-dialysis-the-potential-role-of-intradialytic-exercise
#13
REVIEW
Scott McGuire, Elizabeth Jane Horton, Derek Renshaw, Alofonso Jimenez, Nithya Krishnan, Gordon McGregor
Acute haemodynamic instability is a natural consequence of disordered cardiovascular physiology during haemodialysis (HD). Prevalence of intradialytic hypotension (IDH) can be as high as 20-30%, contributing to subclinical, transient myocardial ischemia. In the long term, this results in progressive, maladaptive cardiac remodeling and impairment of left ventricular function. This is thought to be a major contributor to increased cardiovascular mortality in end stage renal disease (ESRD). Medical strategies to acutely attenuate haemodynamic instability during HD are suboptimal...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682453/when-rett-syndrome-is-due-to-genes-other-than-mecp2
#14
Alan K Percy, Jane Lane, Fran Annese, Hannah Warren, Steven A Skinner, Jeffrey L Neul
Two individuals meeting diagnostic criteria for Rett syndrome (RTT) but lacking a mutation in MECP2 , the gene predominantly associated with this disorder, were provided additional genetic testing. This testing revealed pathogenic mutations in a gene not previously associated with RTT, CTNNB1 , mutations in which lead to an autosomal dominant neurodevelopmental disorder affecting cell signaling and transcription factors as well as a likely pathogenic mutation in the WDR45 gene, which is associated with developmental delay in early childhood and progressive neurodegeneration in adolescence or adulthood related to iron accumulation in the globus pallidus and substantia nigra...
April 13, 2018: Translational Science of Rare Diseases
https://www.readbyqxmd.com/read/29681673/a-qualitative-study-of-cultural-congruency-of-legacy-for-children%C3%A2-for-spanish-speaking-mothers
#15
Lana O Beasley, Jane F Silovsky, Hannah C Espeleta, Lara R Robinson, Sophie A Hartwig, Amanda Morris, Irma Esparza
In recognition of the need to reach more families, the Legacy for Children™ ( Legacy ) program was translated and culturally adapted for Spanish-speaking Hispanic mothers and their infants. This study examined the cultural adaptations and logistical supports needed for successful implementation with Spanish-speaking mothers. The research team used purposive techniques to sample Hispanic bi-lingual providers (N = 14) and supervisors (N = 5) of local home-based parenting programs (Healthy Families, Parents as Teachers, and SafeCare®)...
August 2017: Children and Youth Services Review
https://www.readbyqxmd.com/read/29681262/advancing-canadian-urological-association-guidelines-using-grade
#16
Philipp Dahm, Jane Lewis, Shahnaz Sultan
No abstract text is available yet for this article.
April 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29681058/the-physcomitrella-patens-gene-atlas-project-large-scale-rna-seq-based-expression-data
#17
Pierre-François Perroud, Fabian B Haas, Manuel Hiss, Kristian K Ullrich, Alessandro Alboresi, Mojgan Amirebrahimi, Kerrie Barry, Roberto Bassi, Sandrine Bonhomme, Haodong Chen, Juliet Coates, Tomomichi Fujita, Anouchka Guyon-Debast, Daniel Lang, Junyan Lin, Anna Lipzen, Fabien Nogué, Melvin J Oliver, Inés Ponce de León, Ralph S Quatrano, Catherine Rameau, Bernd Reiss, Ralf Reski, Mariana Ricca, Younousse Saidi, Ning Sun, Peter Szövényi, Avinash Sreedasyam, Jane Grimwood, Gary Stacey, Jeremy Schmutz, Stefan A Rensing
High throughput RNA sequencing (RNA-seq) has recently become the method of choice to define and analyse transcriptomes. For the model moss Physcomitrella patens, although this method has been used to help the analysis of specific perturbations, no overall reference dataset has been established yet. In the framework of its Gene Atlas project, the Joint Genome Institute selected P. patens as a flagship genome, opening the way to generate the first comprehensive transcriptome dataset for this moss. The first round of sequencing described here is composed of 99 independent libraries spanning 34 different developmental stages and conditions...
April 22, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29680827/hiv-seroprevalence-self-reported-stis-and-associated-risk-factors-among-men-who-have-sex-with-men-a-cross-sectional-study-in-rwanda-2015
#18
Roman Saba Ntale, Gad Rutayisire, Pierre Mujyarugamba, Eliah Shema, Jane Greatorex, Simon David William Frost, Pontiano Kaleebu
OBJECTIVES: In many populations, men who have sex with men (MSM) are at a high risk of HIV infection. This study aimed to estimate the burden of HIV, other STIs and risk behaviours among Rwandan MSM. METHODS: In this cross-sectional study, we recruited through peer referral men aged between 18 and 60 years, who reported sex with men at least once in the 12 months prior to the survey. Representativeness was increased using 'seeds' from a variety of sources. Signed informed consent was obtained from all participants...
April 21, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29680771/exercise-induced-left-bundle-branch-block-in-isotopic-exercise-test-findings-and-prognostic-value
#19
M V Gomez, B C Lorente Castro, P Jané, L García-Zoghby, A Martínez-Lorca, J A Pérez
INTRODUCTION: Exercise-induced left bundle branch block (EI-LBBB) is a rare circumstance of unknown significance. The purpose of this paper is to describe the scintigraphic features and the prognostic value of this finding. MATERIAL AND METHODS: We reviewed the features of 1,885 patients who had visited our department to undergo GATED-SPECT ergometry to diagnose ischaemic heart disease. Seven patients showed EI-LBBB throughout the exercise testing. Coronary angiography was performed in 4 of them...
April 18, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29680350/novel-pet-and-near-infrared-imaging-probes-for-the-specific-detection-of-bacterial-infections-associated-with-cardiac-devices
#20
Kiyoko Takemiya, Xinghai Ning, Wonewoo Seo, Xiaojian Wang, Rafi Mohammad, Giji Joseph, Jane S Titterington, Colleen S Kraft, Jonathan A Nye, Niren Murthy, Mark M Goodman, W Robert Taylor
OBJECTIVES: The aim of this study was to develop imaging agents to detect early stage infections in implantable cardiac devices. BACKGROUND: Bacteria ingest maltodextrins through the specific maltodextrin transporter. We developed probes conjugated with either a fluorescent dye (maltohexaose fluorescent dye probe [MDP]) or a F-18 (F18 fluoromaltohexaose) and determined their usefulness in a model of infections associated with implanted cardiac devices. METHODS: Stainless steel mock-ups of medical devices were implanted subcutaneously in rats...
April 13, 2018: JACC. Cardiovascular Imaging
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