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frax rheumatoid

Shan-Fu Yu, Jia-Feng Chen, Yin-Chou Chen, Han-Ming Lai, Chi-Hua Ko, Wen-Chan Chiu, Fu-Mei Su, Chung-Yuan Hsu, Ben Yu-Jih Su, Chih-Hsing Wu, Tien-Tsai Cheng
Glucocorticoid-induced osteoporosis (GIOP) is the most common cause of secondary osteoporosis and confers a substantial risk for future fractures. Several recent guidelines for GIOP management have recommended the use of intervention thresholds to direct pharmacological therapy in those at high risk of fracture. The aim of this study was to analyze the characteristics of subjects on a glucocorticoid (GC) and to implement the Fracture Risk Assessment Tool (FRAX)-based intervention threshold for therapeutic decision-making...
February 2017: Medicine (Baltimore)
Loredana Cavalli, Andrea Guazzini, Luisella Cianferotti, Simone Parri, Tiziana Cavalli, Alessia Metozzi, Francesca Giusti, Caterina Fossi, Dennis M Black, Maria Luisa Brandi
BACKGROUND: BoneTour is a campaign conducted throughout the Italian territory for the assessment of Italian people bone status and for the prevention of osteoporosis. METHODS: A total of 7305 sequential subjects of both sexes were screened, collecting clinical data through the FRAX™ questionnaire, and measuring heel bone stiffness by Quantitative Ultrasonography (QUS). The 10-year risk for hip and major osteoporotic fractures was calculated taking into account personal or family history of fragility fracture, smoking, alcohol abuse, rheumatoid arthritis, prolonged steroids assumption...
2016: BMC Musculoskeletal Disorders
Corinne Klop, Frank de Vries, Johannes W J Bijlsma, Hubert G M Leufkens, Paco M J Welsing
OBJECTIVES: FRAX incorporates rheumatoid arthritis (RA) as a dichotomous predictor for predicting the 10-year risk of hip and major osteoporotic fracture (MOF). However, fracture risk may deviate with disease severity, duration or treatment. Aims were to validate, and if needed to update, UK FRAX for patients with RA and to compare predictive performance with the general population (GP). METHODS: Cohort study within UK Clinical Practice Research Datalink (CPRD) (RA: n=11 582, GP: n=38 755), also linked to hospital admissions for hip fracture (CPRD-Hospital Episode Statistics, HES) (RA: n=7221, GP: n=24 227)...
December 2016: Annals of the Rheumatic Diseases
Eun Jin Jang, Young-Kyun Lee, Hyung Jin Choi, Yong-Chan Ha, Sunmee Jang, Chan Soo Shin, Nam Han Cho
BACKGROUND: Fracture-risk assessment tool (FRAX) using just clinical risk factors of osteoporosis has been developed to estimate individual risk of osteoporotic fractures. We developed prediction model of fracture risk using bone mineral density (BMD) as well as clinical risk factors in Korean, and assessed the validity of the final model. METHODS: To develop and validate an osteoporotic FRAX, a total of 768 Korean men and women aged 50 to 90 years were followed for 7 years in a community-based cohort study...
February 2016: Journal of Bone Metabolism
F Malgo, N M Appelman-Dijkstra, M F Termaat, H J L van der Heide, I B Schipper, T J Rabelink, N A T Hamdy
UNLABELLED: In this study, we demonstrate a high prevalence of secondary factors in patients with a recent fracture independently of bone mineral density (BMD). Our results suggest that patients with a recent fracture should be screened for secondary factors for bone fragility regardless of BMD values. INTRODUCTION: Secondary factors for bone fragility are common in patients with osteoporosis who have sustained a fracture. The majority of fragility fractures occurs, however, in patients with osteopenia, and it is not known whether secondary factors may contribute to fracture risk in these patients or in those with normal BMD...
2016: Archives of Osteoporosis
Yasser El Miedany
Rheumatoid arthritis patients are clinically complex, and the interplay of their disease activity together with the other associated conditions may lead to increased morbidity and mortality. The recent advances in the disease management attracted the attention to its associated co-morbidities and highlighted the need for a tool to provide clinicians and potential payers with a clinically powerful measure of the disease burden and prognosis. Predicting outcome or co-morbidity probability has been previously implemented successfully for calculating 10-year fracture probability (FRAX) as well as for predicting 1-year patient mortality using co-morbidity data obtained (Charlson index)...
December 2015: Clinical Rheumatology
Yu Wang, Yan-jie Hao, Xue-rong Deng, Guang-tao Li, Yan Geng, Juan Zhao, Wei Zhou, Zhuo-li Zhang
OBJECTIVE: To verify the fracture risk assessment tool (FRAX) to estimate the probability of osteoporotic fracture in patients with rheumatoid arthritis (RA) with or without bone mineral density (BMD), and identify associated risk factors of osteoporosis. METHODS: In the study, 200 patients with rheumatoid arthritis aged more than 40 years in Peking University First Hospital from Dec. 2009 to Dec. 2012 were recruited. Clinical information was obtained from a questionnaire of their case history and medical records...
October 18, 2015: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Maria Luz Rentero, Encarna Amigo, Nicolas Chozas, Manuel Fernández Prada, Lucia Silva-Fernández, Miguel Angel Abad Hernandez, Jose Maria Rodriguez Barrera, Javier del Pino-Montes
BACKGROUND: Glucocorticoid (GC) therapy is associated with an increased risk of fractures. The main objective of this study was to determine the prevalence of undiagnosed vertebral fractures in women chronically using GC therapy for autoimmune disorders. We also determined the prevalence of non-vertebral fractures, and investigated whether factors such as quality-of-life and future fracture risk are associated with vertebral/non-vertebral fractures. METHODS: This was a multicenter cross-sectional study conducted in Spain...
2015: BMC Musculoskeletal Disorders
Dam Kim, Soo-Kyung Cho, Ji Young Kim, Yun Young Choi, Yoon-Kyoung Sung
OBJECTIVE: To identify the association between trabecular bone score (TBS) and other known risk factors for fractures in rheumatoid arthritis (RA) patients. METHODS: One hundred female RA patients aged ≥50 years were enrolled. The following risk factors for fracture were selected: prevalent vertebral fracture (VF), bone mineral density (BMD), TBS, and 10-year probability of major osteoporotic fracture by FRAX® (MOF-FRAX scores). The associations between risk factors were identified, and accuracy of TBS, BMD, and FRAX scores to detect the prevalent VF, the strongest risk factor for future fracture, were assessed...
July 2016: Modern Rheumatology
W Pluskiewicz, P Adamczyk, A Czekajło, W Grzeszczak, B Drozdzowska
UNLABELLED: In 770 postmenopausal women, the fracture incidence during a 4-year follow-up was analyzed in relation to the fracture probability (FRAX risk assessment tool) and risk (Garvan risk calculator) predicted at baseline. Incident fractures occurred in 62 subjects with a higher prevalence in high-risk subgroups. Prior fracture, rheumatoid arthritis, femoral neck T-score and falls increased independent of fracture incidence. INTRODUCTION: The aim of the study was to analyze the incidence of fractures during a 4-year follow-up in relation to the baseline fracture probability and risk...
December 2015: Osteoporosis International
Jos N Hoes, Irene E M Bultink, Willem F Lems
INTRODUCTION: In rheumatoid arthritis (RA) patients, the risk of both vertebral and non-vertebral fractures is roughly doubled, which is for an important part caused by inflammation-mediated amplification of bone loss and by immobilization. New treatments have become available in the last two decades to treat both RA and osteoporosis. AREAS COVERED: Epidemiology and assessment of osteoporosis and fracture risk (including the influence of RA disease activity and bone-influencing medications such as glucocorticoids), the importance of vertebral fracture assessment in addition to bone density measurement in patients with RA, the use of disease-modifying antirheumatic drugs and their effects on generalized bone loss, and current and possible future anti-osteoporotic pharmacotherapeutic options are discussed with special focus on RA...
March 2015: Expert Opinion on Pharmacotherapy
Sebastión Carranza-Lira, María Cristina Lanuza-López, Martha Patricia Sandoval-Barragán
BACKGROUND: The FRAX tool allows calculate the 10 year probability of fracture risk in men and women. OBJECTIVE: To compare the 10 years fracture risk calculated with the FRAX tool using or not bone densitometry. MATERIAL AND METHODS: A prospective, cross-sectional, open a comparative study was done with 40-80-year-old women, who were evaluated with bone densitometry. To calculate the fracture risk the FRAX tool was used with and without bone densitometry in each patient...
September 2014: Ginecología y Obstetricia de México
Jae Ho Lee, Young Sun Suh, Jung Hee Koh, Seung-Min Jung, Jennifer Jooha Lee, Seung-Ki Kwok, Ji Hyeon Ju, Kyung-Su Park, Sung-Hwan Park
The aim of the current study is to identify patients without osteoporosis who met the criteria of the fracture risk assessment tool (FRAX) of the National Osteoporosis Foundation (NOF) only. The incidence of fractures was investigated in patients who met only the FRAX criteria of the NOF and patients who presented osteoporosis. Five hundred and forty five patients with rheumatoid arthritis who visited a single center were recruited in Korea. In the follow-up period of median 30 months, the new onset of fractures was investigated...
August 2014: Journal of Korean Medical Science
Agnieszka Matuszewska, Jacek Szechiński
Rheumatoid arthritis (RA) is progressive, chronic, autoimmune, systemic connective tissue disease. It affects 0,5-1% population. RA manifests as inflammation of symmetrical mainly small and medium joints with synovial hypertrophy, extra-articular lesions and systemic complications. Depending on intensity and duration of RA in imaging studies the patients demonstrate narrowing of articular fissures, presence of geodes, erosions, subluxations and/or synostoses. Progressive bone mass loss in the joint involved by the morbid process and in the entire skeleton was also described...
2014: Postȩpy Higieny i Medycyny Doświadczalnej
Alfred K Pfister, Christine A Welch, Mary K Emmett, Nicholas W Sheets
Abstract Few studies exist evaluating fracture prediction in women aged 50-59. Clinical risk factors are important determinants for fracture prediction in younger postmenopausal women since most fractures occur outside the range of an osteoporotic bone mineral density. Although fracture incidence rates in this age group are about one-half of those aged 60-69, considerable costs and loss of quality-adjusted life years are still incurred in this age group. We sought to determine what clinical risk factors would predict subsequent fractures...
May 2013: West Virginia Medical Journal
Teresa Friis-Holmberg, Katrine Hass Rubin, Kim Brixen, Janne Schurmann Tolstrup, Mickael Bech
In this prospective study, we investigated the ability of Fracture Risk Assessment Tool (FRAX), phalangeal bone mineral density (BMD), and age alone to predict fractures using data from a Danish cohort study, Danish Health Examination Survey 2007-2008, including men (n = 5206) and women (n = 7552) aged 40-90 yr. Data were collected using a self-administered questionnaire and by phalangeal BMD measurement. Information on incident and prevalent fractures, rheumatoid arthritis, and secondary osteoporosis was retrieved from the Danish National Patient Registry...
January 2014: Journal of Clinical Densitometry
Wojciech P Olszynski, Jacques P Brown, Jonathan D Adachi, David A Hanley, George Ioannidis, Kenneth S Davison
This study assessed the ability of multisite quantitative ultrasound (mQUS) to predict fracture over a 5-year follow-up. Participants were a subset of the Canadian Multicentre Osteoporosis Study. mQUS-assessed speed of sound (SOS in m/s) at three sites (distal radius, tibia, and phalanx) and extensive questionnaires were completed, after which participants were followed for 5 years and incident fractures recorded. Two survival analyses were completed for each site--a univariate analysis and an adjusted multivariate analysis controlling for age, antiresorptive use, femoral neck bone mineral density, number of diseases, previous fractures, body mass index (BMI), parental history of hip fracture, current smoking, current alcoholic drinks >3 per day, current use of glucocorticoids, and rheumatoid arthritis diagnosis (variables from the FRAX 10-year fracture risk assessment tool)...
September 2013: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Carmelo Erio Fiore, Agostino Gaudio
FRAX(®) is a computer-based algorithm developed by the World Health Organization Collaborating Centre for Metabolic Bone Diseases in Sheffield (UK). This algorithm calculates fracture probability from easily obtained clinical risk factors in men and women: age, sex, body mass index and dichotomized variables comprising prior fragility fracture, parental history of hip fracture, current tobacco smoking, use of long-term oral glucocorticoid, rheumatoid arthritis, other causes of secondary osteoporosis and high alcohol consumption (femoral neck bone mineral density can be optionally input to enhance fracture risk prediction)...
September 2012: Clinical Cases in Mineral and Bone Metabolism
Rafael Azagra, Genís Roca, Gloria Encabo, Amada Aguyé, Marta Zwart, Sílvia Güell, Núria Puchol, Emili Gene, Enrique Casado, Pilar Sancho, Silvia Solà, Pere Torán, Milagros Iglesias, Maria Carmen Gisbert, Francesc López-Expósito, Jesús Pujol-Salud, Yolanda Fernandez-Hermida, Ana Puente, Mireia Rosàs, Vicente Bou, Juan José Antón, Gustavo Lansdberg, Juan Carlos Martín-Sánchez, Adolf Díez-Pérez, Daniel Prieto-Alhambra
BACKGROUND: The WHO has recently published the FRAX® tool to determine the absolute risk of osteoporotic fracture at 10 years. This tool has not yet been validated in Spain. METHODS/DESIGN: A prospective observational study was undertaken in women in the FRIDEX cohort (Barcelona) not receiving bone active drugs at baseline. Baseline measurements: known risk factors including those of FRAX® and a DXA. Follow up data on self-reported incident major fractures (hip, spine, humerus and wrist) and verified against patient records...
October 22, 2012: BMC Musculoskeletal Disorders
Ana Maria Rodrigues, Joana Caetano-Lopes, Ana Catarina Vale, Inês Aleixo, Ana Sofia Pena, Alexandra Faustino, Alexandre Sepriano, Joaquim Polido-Pereira, Elsa Vieira-Sousa, Raquel Lucas, José Carlos Romeu, Jacinto Monteiro, Maria Fátima Vaz, João Eurico Fonseca, Helena Canhão
Clinical risk factors (CRFs) are established predictors of fracture events. However, the influence of individual CRFs on trabecular mechanical fragility is still a subject of debate. In this study, we aimed to assess differences, adjusted for CRFs, between bone macrostructural parameters measured in ex-vivo specimens from hip fragility fracture patients and osteoarthritis patients, and to determine whether individual CRFs could predict trabecular bone mechanical behavior in hip fragility fractures. Additionally, we also looked for associations between the 10-year risk of major and hip fracture calculated by FRAX and trabecular bone mechanical performance...
November 2012: Journal of Bone and Mineral Metabolism
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