Shibo Zhong, Shuai Huang, Bin Feng, Ting Luo, Feiyi Chu, Fan Zheng, Yingli Zhu, Fei Chen, Wenbin Zeng
As a chronic inflammatory disease, rheumatoid arthritis (RA) can cause progressive damage to joints and various organs. Hydrogen peroxide plays a significant role in the pathogenesis and progression of RA and thus serves as a biomarker for diagnosing this disease. Although fluorescent probes have emerged as promising tools for detecting H2 O2 , most available ones suffer from the aggregation-caused quenching (ACQ) effect, short-wavelength emission, low sensitivity, and poor water solubility. Herein, a new type of "turn-on" AIE probe based on excited state intramolecular proton transfer (ESIPT) was developed, with phenylboronic acid pinacol ester-appended quinolinium as the H2 O2 recognition site, which is in the quenched state due to the twisted intramolecular charge transfer (TICT) effect...
June 5, 2023: Organic & Biomolecular Chemistry