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Biomarker appendicitis

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https://www.readbyqxmd.com/read/27922766/diagnostic-value-of-high-mobility-group-box-1-hmgb1-protein-in-acute-and-perforated-appendicitis
#1
Shabanali Alizadeh, Ali Ghazavi, Ali Ganji, Ghasem Mosayebi
AIM: Acute appendicitis is the most common cause of abdominal surgical emergencies. Early diagnosis of appendicitis can reduce perforation and mortality rate. High-mobility group box 1 (HMGB1) protein has been identified as a pro-inflammatory factor and its elevated serum levels have been noted in different diseases. So, the aim of this study was to determine the serum levels of HMGB1 in patients with acute and perforated appendicitis in compare to normal appendix. MATERIAL AND METHODS: For this purpose, serum samples were obtained from 81 patients with primary criteria-based appendicitis 6 hr before and 72 hr after appendectomy, in which serum levels of HMGB1 were analyzed by enzyme-linked immunosorbent assay...
December 6, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27876541/diagnostic-performance-of-a-biomarker-panel-as-a-negative-predictor-for-acute-appendicitis-in-adult-emergency-department-patients-with-abdominal-pain
#2
David S Huckins, Karen Copeland, Wesley Self, Cheryl Vance, Phyllis Hendry, Keith Borg, Joseph Gogain
OBJECTIVES: Evaluate the diagnostic accuracy of the APPY1TM biomarker panel, previously described for use in pediatric patients, for identifying adult ED patients with abdominal pain who are at low risk of acute appendicitis. METHODS: This study prospectively enrolled subjects >18years of age presenting to seven U.S. emergency departments with <72hours of abdominal pain suggesting possible acute appendicitis. The APPY1 panel was performed on blood samples drawn from each patient at the time of initial evaluation and results were correlated with the final diagnosis either positive or negative for acute appendicitis...
November 11, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27769665/ischemia-modified-albumin-as-a-predictor-of-the-severity-of-acute-appendicitis
#3
Murat Özgür Kılıç, Cem Emir Güldoğan, İlhan Balamir, Mesut Tez
BACKGROUND: The early prediction of gangrenous/perforated appendicitis is of great importance for the surgical planning, further treatments, and predicting the course of disease. Ischemia-modified albumin (IMA) was previously reported as a biomarker of various ischemia-based diseases. Our aim is to determine the predictive value of serum IMA in the severity of acute appendicitis. METHODS: Sixty-two patients who underwent urgent appendectomy were included in the study...
October 7, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27760719/diagnostic-accuracy-of-fibrinogen-to-differentiate-appendicitis-from-nonspecific-abdominal-pain-in-children
#4
Marcos Prada-Arias, José Luis Vázquez, Ángel Salgado-Barreira, Javier Gómez-Veiras, Margarita Montero-Sánchez, José Ramón Fernández-Lorenzo
AIM: The aim of this study was to assess the diagnostic accuracy of the biomarker fibrinogen (FB), along with the more traditional markers white blood cell count (WBC), absolute neutrophil count (ANC), and C-reactive protein (CRP), to discriminate appendicitis from nonspecific abdominal pain (NSAP) in children. METHODS: We prospectively evaluated all children aged 5 to 15 years admitted for suspected appendicitis at an academic pediatric emergency department during 2 years...
October 5, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27745729/addition-of-a-biomarker-panel-to-a-clinical-score-to-identify-patients-at-low-risk-for-appendicitis
#5
Holly Depinet, Karen Copeland, Joseph Gogain, Halim Hennes, Norman A Paradis, Rebecca Andrews-Dickert, Cheryl W Vance, David S Huckins
BACKGROUND: The diagnosis of pediatric acute appendicitis can be difficult. Although scoring systems such as the Pediatric Appendicitis Score (PAS) are helpful, they lack adequate sensitivity and specificity as standalone diagnostics. When used for risk stratification, they often result in large percentages of moderate-risk patients requiring further diagnostic evaluation. METHODS: We applied a biomarker panel (the APPY1 Test) that has high sensitivity and negative predictive value (NPV) to patients with PAS in the moderate-risk range (3-7) and reclassified those patients with a negative result to the low-risk group...
August 10, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27609121/evaluation-of-proadrenomedullin-as-a-diagnostic-or-prognostic-biomarker-of-acute-appendicitis-in-children
#6
Concepción Míguez, Cristina Tomatis Souverbielle, Ana Haro, Gloria Guerrero, Laura Pérez-Egido, Mercedes García-Gamiz, Rafael Marañon
INTRODUCTION: A delay in the diagnosis of acute appendicitis (AA), with the added complication of symptoms that mimic other self-limited causes of abdominal pain, can lead to an increase in ruptured appendices and morbimortality. None of the serum biomarkers evaluated to date have shown a predictive value for early diagnosis. OBJECTIVE: The objective of this study was to evaluate the usefulness of proadrenomedullin (MR-proADM) in the diagnosis of AA in children presenting with acute abdominal pain...
August 16, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27503397/metrics-for-monitoring-cancer-inequities-residential-segregation-the-index-of-concentration-at-the-extremes-ice-and-breast-cancer-estrogen-receptor-status-usa-1992-2012
#7
Nancy Krieger, Nakul Singh, Pamela D Waterman
PURPOSE: To address the paucity of evidence on residential segregation and cancer, we explored their relationship using a new metric: the Index of Concentration at the Extremes (ICE). We focused on breast cancer estrogen receptor (ER) status, a biomarker associated with survival and, etiologically, with social and economic privilege. METHODS: We obtained data from the 13 registry group of US Surveillance, Epidemiology, and End Results (SEER) program for 1992-2012 on all women aged 25-84 who were diagnosed with primary invasive breast cancer (n = 516,382)...
September 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27495334/biomarkers-of-acute-appendicitis-systematic-review-and-cost-benefit-trade-off-analysis
#8
Amish Acharya, Sheraz R Markar, Melody Ni, George B Hanna
BACKGROUND: Acute appendicitis is the most common surgical emergency and can represent a challenging diagnosis, with a negative appendectomy rate as high as 20 %. This review aimed to evaluate the clinical utility of individual biomarkers in the diagnosis of appendicitis and appraise the quality of these studies. METHODS: A systematic review of the literature between January 2000 and September 2015 using of PubMed, OvidMedline, EMBASE and Google Scholar was conducted...
August 5, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27417541/acute-appendicitis-transcript-profiling-of-blood-identifies-promising-biomarkers-and-potential-underlying-processes
#9
Lakhmir S Chawla, Ian Toma, Danielle Davison, Khashayar Vaziri, Juliet Lee, Raymond Lucas, Michael G Seneff, Aoibhinn Nyhan, Timothy A McCaffrey
BACKGROUND: The diagnosis of acute appendicitis can be surprisingly difficult without computed tomography, which carries significant radiation exposure. Circulating blood cells may carry informative changes in their RNA expression profile that would signal internal infection or inflammation of the appendix. METHODS: Genome-wide expression profiling was applied to whole blood RNA of acute appendicitis patients versus patients with other abdominal disorders, in order to identify biomarkers of appendicitis...
2016: BMC Medical Genomics
https://www.readbyqxmd.com/read/27351432/urinary-biomarkers-in-pediatric-appendicitis
#10
Martin Salö, Bodil Roth, Pernilla Stenström, Einar Arnbjörnsson, Bodil Ohlsson
PURPOSE: The diagnosis of pediatric appendicitis is still a challenge, resulting in perforation and negative appendectomies. The aim of this study was to evaluate novel biomarkers in urine and to use the most promising biomarkers in conjunction with the Pediatric Appendicitis Score (PAS), to see whether this could improve the accuracy of diagnosing appendicitis. METHODS: A prospective study of children with suspected appendicitis was conducted with assessment of PAS, routine blood tests, and measurements of four novel urinary biomarkers: leucine-rich α-2-glycoprotein (LRG), calprotectin, interleukin 6 (IL-6), and substance P...
August 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27133536/prospective-validation-of-a-biomarker-panel-to-identify-pediatric-ed-patients-with-abdominal-pain-who-are-at-low-risk-for-acute-appendicitis
#11
David S Huckins, Harold K Simon, Karen Copeland, Truman J Milling, Philip R Spandorfer, Halim Hennes, Coburn Allen, Joseph Gogain
OBJECTIVES: The objective of the study is to prospectively validate the diagnostic accuracy of a biomarker panel consisting of white blood cell, C-reactive protein, and myeloid-related protein 8/14 levels in identifying pediatric patients with abdominal pain who are at low risk for appendicitis. METHODS: This prospective observational study enrolled subjects aged 2 to 20 years presenting to 29 US emergency departments with abdominal pain suggesting possible acute appendicitis...
August 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27118309/calprotectin-could-be-a-potential-biomarker-for-acute-appendicitis
#12
Peter C Ambe, Daniel Gödde, Lars Bönicke, Marios Papadakis, Stephan Störkel, Hubert Zirngibl
BACKGROUND: Acute appendicitis is a common cause for a visit to the emergency department and appendectomy represents the most common emergency procedure in surgery. The rate of negative appendectomy however has remained high despite modern diagnostic apparatus. Therefore, there is need for a better preoperative screening of patients with suspected appendicitis. Calprotectin represents a predominant protein in the cytosol of neutrophil granulocytes and has been extensively investigated with regard to bowel pathologies...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27088305/pre-assembly-of-near-infrared-fluorescent-multivalent-molecular-probes-for-biological-imaging
#13
Evan M Peck, Paul M Battles, Douglas R Rice, Felicia M Roland, Kathryn A Norquest, Bradley D Smith
A programmable pre-assembly method is described and shown to produce near-infrared fluorescent molecular probes with tunable multivalent binding properties. The modular assembly process threads one or two copies of a tetralactam macrocycle onto a fluorescent PEGylated squaraine scaffold containing a complementary number of docking stations. Appended to the macrocycle periphery are multiple copies of a ligand that is known to target a biomarker. The structure and high purity of each threaded complex was determined by independent spectrometric methods and also by gel electrophoresis...
May 18, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27075266/evaluation-of-mediators-of-oxidative-stress-and-inflammation-in-patients-with-acute-appendicitis
#14
Sandra Lorena de Oliveira Machado, Margarete Dulce Bagatini, Pauline da Costa, Jucimara Baldissarelli, Karine Paula Reichert, Lizielle Souza de Oliveira, Jéssica Gonçalves Lemos, Thiago Duarte, Maria Rosa Chitolina Schetinger, Vera Maria Morsch
CONTEXT: This study aims to explore the potential of new inflammatory markers for improving the challenging diagnosis of acute appendicitis (AA). METHODS: Levels of IL-1, IL-6, IL-8, IL-10, CRP, INF-γ, and TNF-α in serum were measured in 73 patients with AA. Oxidative stress and antioxidant enzymes were analyzed. RESULTS: Serum levels of interleukins, TNF-α, and INF-γ were significantly elevated in patients with appendicitis (p < 0...
September 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27026889/neutrophil-gelatinase-associated-lipocal-in-protein-levels-as-an-acute-appendicitis-biomarker-in-children
#15
Unal Bakal, Mehmet Saraç, Harun Ciftci, Tugay Tartar, Esra Kocdemir, Suleyman Aydin, Ahmet Kazez
OBJECTIVE: Appendicitis is very commonly encountered in emergency clinics. There is an urgent need for early and accurate predictive biomarkers of appendicitis in order to save lives, because currently-available biomarkers are imprecise and their delayed response impairs the ability of emergency doctors and pediatric surgeons to provide timely and potentially effective therapies. This study was performed to determine whether changes in the blood levels of neutrophil gelatinase-associated lipocalin (NGAL) can help to diagnose acute appendicitis in children and distinguish acute appendicitis from abdominal pain...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27025584/serum-cholinesterase-a-potential-assistant-biomarker-for-hand-foot-and-mouth-disease-caused-by-enterovirus-71-infection
#16
Bang-Ning Cheng, Yu-Lian Jin, Bi-Quan Chen, Li-Yan Zhu, Zi-Cheng Xu, Tao Shen
BACKGROUND: Hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) is a potentially life-threatening infectious disease that commonly occurs in children. Diagnosis of HFMD caused by EV71 largely depends on clinical manifestations and rare serological biomarkers used to identify children suffering from HFMD. Serum cholinesterase (SChE) activity has frequently been reported as a potential biomarker for solid central nervous system tumors, chronic heart failure, and liver cirrhosis...
March 29, 2016: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/26976278/elevated-serum-alpha-fetoprotein-in-poorly-differentiated-adenocarcinoma-with-neuroendocrine-differentiation-of-the-ascending-colon-a-case-report
#17
Hung-Hsin Lin, Chia-Chu Chang, Shung-Haur Yang, Shih-Ching Chang, Wei-Shone Chen, Wen-Yih Liang, Jen-Kou Lin, Jeng-Kai Jiang
BACKGROUND: Colorectal cancer (CRC) is the most common form of cancer and the third leading cause of death in Taiwan. Serum alpha-fetoprotein (AFP) has been extensively used as a biomarker for hepatocellular carcinoma (HCC) and yolk sac tumors. CASE PRESENTATION: This case report presents a 90-year-old woman with right abdominal pain and poor appetite for 1 week. The computed tomography (CT) showed wall thickening in the proximal ascending colon with ruptured appendicitis...
2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26935221/usefulness-of-new-and-traditional-serum-biomarkers-in-children-with-suspected-appendicitis
#18
J Benito, Y Acedo, L Medrano, E Barcena, R Perez Garay, E Arana Arri
OBJECTIVE: The objective of the study is to evaluate the usefulness of the leukocyte (white blood count [WBC]) and neutrophil (absolute neutrophil count [ANC]) counts; the values of C-reactive protein (CRP), procalcitonin, and calprotectin (CP); and the APPY1 Test panel of biomarkers, to identify children with abdominal pain at low risk for appendicitis. METHOD: Children 2 to 14 years of age with abdominal pain suggesting acute appendicitis (AA) were prospectively included...
May 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/26714766/polymorphisms-in-the-il-6-and-il-6r-receptor-genes-as-new-diagnostic-biomarkers-of-acute-appendicitis-a-study-on-two-candidate-genes-in-pediatric-patients-with-acute-appendicitis
#19
Sevgi Büyükbeşe Sarsu, Şenay Görücü Yılmaz, Ali Bayram, Affan Denk, Kürşat Kargun, Mehmet Ali Sungur
BACKGROUND: Acute appendicitis (AA) (OMIM: 107700) is an inflammatory disease which is characterized by appendiceal inflammation. Genetic and environmental factors contribute to the development of AA. Especially, multiple genetic factors appear to be promising in the explanation of etiopathogenesis of AA. IL-6 (Interleukin-6) is an inflammatory cytokine and IL-6 receptor (IL-6R) plays an important role in the immune response. IL-6 (-572G/C rs1800796) and IL-6R (1:G.154448302 T > C rs7529229) gene polymorphisms may have an impact on cytokine production, immune response and these gene polymorphisms may be used as inflammatory markers in the diagnosis of appendicitis...
December 29, 2015: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/26545015/infectious-diseases-are-associated-with-carotid-intima-media-thickness-in-adolescence
#20
Julia Dratva, Seraina Caviezel, Emmanuel Schaffner, Robert Bettschart, Nino Kuenzli, Christian Schindler, Arno Schmidt-Trucksäss, Daiana Stolz, Elisabeth Zemp, Nicole Probst-Hensch
OBJECTIVE: Inflammatory risk factors in childhood, e.g. obesity, impact on carotid artery intima media thickness (CIMT), an early indicator of atherosclerosis. Little is known on potential infectious origins in childhood. We investigated the association between number of reported different childhood infectious diseases and CIMT in adolescence. STUDY DESIGN: 288 SAPALDIA offspring (8-21years) underwent a clinical examination in 2010-2011: anthropometry, blood pressure, CIMT, blood draw (cardiovascular biomarkers, cotinine)...
December 2015: Atherosclerosis
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