Read by QxMD icon Read

Iron treatment

Giorgio Vilardi, Thanasis Mpouras, Dimitris Dermatas, Nicola Verdone, Angeliki Polydera, Luca Di Palma
Carbon Nanotubes (CNTs) and nano Zero-Valent Iron (nZVI) particles, as well as two nanocomposites based on these novel nanomaterials, were employed as nano-adsorbents for the removal of hexavalent chromium, selenium and cobalt, from aqueous solutions. Nanomaterials characterization included the determination of their point of zero charge and particle size distribution. CNTs were further analyzed using scanning electron microscopy, thermogravimetric analysis and Raman spectroscopy to determine their morphology and structural properties...
March 5, 2018: Chemosphere
Fengxia Deng, Hugo Olvera-Vargas, Orlando Garcia-Rodriguez, Shan Qiu, Jixian Yang, Olivier Lefebvre
A composite nickel-iron-foam (Ni-Fe-F) electrode was used as a cathode in the electro-Fenton (EF) process at circum-neutral pH in the presence of sodium tripolyphosphate (TPP) as supporting electrolyte. It was found that phenol degradation was dramatically improved by the synergistic effect of Ni-Fe-F and TPP, reaching 100% removal in 40 min, with kapp  = (8.90 ± 0.12) × 10-2 min-1 , which was about 18 times higher than that of Ni-Fe-F with sulfate as conventional electrolyte at pH 3.00 (kapp  = (5...
March 5, 2018: Chemosphere
Piera Valenti, Luigi Rosa, Daniela Capobianco, Maria Stefania Lepanto, Elisa Schiavi, Antimo Cutone, Rosalba Paesano, Paola Mastromarino
The innate defense system of the female mucosal genital tract involves a close and complex interaction among the healthy vaginal microbiota, different cells, and various proteins that protect the host from pathogens. Vaginal lactobacilli and lactoferrin represent two essential actors in the vaginal environment. Lactobacilli represent the dominant bacterial species able to prevent facultative and obligate anaerobes outnumber in vaginal microbiota maintaining healthy microbial homeostasis. Several mechanisms underlie the protection exerted by lactobacilli: competition for nutrients and tissue adherence, reduction of the vaginal pH, modulation of immunity, and production of bioactive compounds...
2018: Frontiers in Immunology
Amir Bostani
The solubility of iron (Fe), as an important micronutrient for plant growth, is not high in the calcareous soils, and hence efficient methods must be used to increase its availability for plant use. Accordingly, a two-year research work was conducted to investigate the effects of composted municipal solid wastes (MSW) on Fe accumulation and fractionation in a calcareous soil. Treatments including MSW levels at (0 (control), 15 (MSW1), 30 (MSW2) and 60 (MSW3) t ha-1 dry weight) and usage time (yearly (T1) or biyearly usage (T2)) were tested in a factorial experiment on the basis of a completely randomized block design with three replications...
May 2018: Journal of Trace Elements in Medicine and Biology
Joanna Suliburska, Katarzyna Skrypnik, Monika Szulińska, Justyna Kupsz, Paweł Bogdański
BACKGROUND: Hypotensive therapy leads to a number of trace elements metabolism disturbances. Zinc balance is frequently affected by antihypertensive treatment. AIM: To evaluate the effect of a hypotensive treatment, modified diet and zinc supplementation on mineral status and selected biochemical parameters in newly diagnosed hypertensive patients on monotherapy. METHODS: In the first stage, arterial hypertension in ninety-eight human subjects was diagnosed...
May 2018: Journal of Trace Elements in Medicine and Biology
H A Alhazmi
Transferrin is iron (III)-binding protein that transports Fe (III) ion to cells in different parts of the body. At saturation level 70% of transferrin remains free from iron (apo-transferrin), suggesting a broader scope of binding capabilities with non-iron (III) metal ions. Our previous work demonstrated that transferrin can effectively coordinate with noble metal ions. Hence to improve our understanding of the in-vitro metal-interaction behavior of the protein and how it correlates with its functions invivo, the interactions between apo-transferrin and medicinally important noble metals, Au (I), Au (III), Os (III), Pt (IV), Ir (III) and Ru (III) were investigated in the mobility shift mode of affinity capillary electrophoresis...
March 5, 2018: Die Pharmazie
Wendy L St Peter, Haifeng Guo, Shaum Kabadi, David T Gilbertson, Yi Peng, Trudy Pendergraft, Suying Li
BACKGROUND: Anemia is common in non-dialysis-dependent chronic kidney disease (NDD-CKD) patients, but detailed information on prevalence and treatment is lacking. METHODS: We evaluated anemia prevalence and treatment using two datasets: the Medicare 20% random sample (ages 66-85 years), and the Truven Health MarketScan database (ages 18-63 years). We selected stage 3-5 NDD-CKD patients with and without anemia from both databases during 2011-2013. We evaluated anemia prevalence and treatment (erythropoietin stimulating agents [ESAs], intravenous [IV] iron, red blood cell [RBC] transfusions) following anemia diagnosis during a 1-year baseline period, and healthcare utilization during a 1-year follow-up period...
March 15, 2018: BMC Nephrology
Rensheng Cao, Mingyi Fan, Jiwei Hu, Wenqian Ruan, Xianliang Wu, Xionghui Wei
Highly promising artificial intelligence tools, including neural network (ANN), genetic algorithm (GA) and particle swarm optimization (PSO), were applied in the present study to develop an approach for the evaluation of Se(IV) removal from aqueous solutions by reduced graphene oxide-supported nanoscale zero-valent iron (nZVI/rGO) composites. Both GA and PSO were used to optimize the parameters of ANN. The effect of operational parameters (i.e., initial pH, temperature, contact time and initial Se(IV) concentration) on the removal efficiency was examined using response surface methodology (RSM), which was also utilized to obtain a dataset for the ANN training...
March 15, 2018: Materials
Carles Díez-López, Josep Comín-Colet, José González-Costello
PURPOSE OF REVIEW: Iron overload cardiomyopathy (IOC) is an important predictor of prognosis in a significant number of patients with hereditary hemochromatosis and hematologic diseases. Its prevalence is increasing because of improved treatment strategies, which significantly improve life expectancy. We will review diagnosis, treatment, and recent findings in the field. RECENT FINDINGS: The development of preclinical translational disease models during the last years have helped our understanding of specific disease pathophysiological pathways that might eventually change the outcomes of these patients...
March 14, 2018: Current Opinion in Cardiology
E Millart, S Lesieur, V Faivre
Introduction The development of multifunctional drug carriers provides many opportunities in the field of drug delivery. Among them, carriers loaded with both drug and superparamagnetic iron oxide nanoparticles would allow the combination of chemotherapy with the possibility of monitoring or controlling the distribution of the nanocarrier in the body, triggering drug release and/or applying a synergistic hyperthermia treatment. Areas covered The present review covers biocompatible lipid-based nanotechnologies that have been employed to co-encapsulate drug and iron oxide...
March 15, 2018: Expert Opinion on Drug Delivery
Yan Li, Dewen Ye, Mingxi Li, Ming Ma, Ning Gu
The paper provides a brief overview of the use of iron oxide nanoparticles (IONPs) in the areas of bone regenerative medicine. Reconstruction of bone defects caused by trauma, non-union, and bone tumour excision still faces many challenges despite the intense investigations and advancement in bone tissue engineering and bone regeneration over the past decades. IONPs have promising prospects in this field due to their controlled responsive characteristics in specific external magnetic fields and have been of great interest during the last few years...
March 14, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Omkara Swami Muddineti, Preeti Kumari, Balaram Ghosh, Swati Biswas
PURPOSE: Transferrin receptor (TfR) is up-regulated in various malignant tumors not only to meet the iron requirement, but also to increase the cell survival via participation in various cellular signaling pathways. Here we explored transferrin as ligand for Poly(ethylene Glycol) (PEG)-ylated vitamin-E/lipid (PE) core micelles (VPM). METHODS: Transferrin modified polymer was synthesized and drug loaded micelles were evaluated in 2D Hela and HepG2 cancer cells for cellular uptake and cytotoxicity and in 3D Hela spheroids for growth inhibition, uptake and penetration studies...
March 14, 2018: Pharmaceutical Research
Mary Guaraldi, Thomas B Shea
Objective: We examined genetic and dietary challenge on hippocampal oxidative damage. Mice expressing (ApoE+/+) or lacking apolipoprotein E (ApoE-/-) were maintained on a standard diet or a high fat /high cholesterol (challenge) diet for 11-31 weeks. Similar levels of oxidative species were observed for ApoE+/+ and -/- mice maintained on the basal diet. Method: However, treatment of ApoE-/- homogenates with hydrogen peroxide and iron increased oxidative species by >100%, indicating an equivalent amount of potential oxidative species in latent form...
2018: Open Neurology Journal
Adélaïde Compaoré, Sabine Gies, Bernard Brabin, Halidou Tinto, Loretta Brabin
BACKGROUND: Iron deficiency remains a prevalent adolescent health problem in low income countries. Iron supplementation is recommended but improvement of iron status requires good adherence. OBJECTIVES: We explored factors affecting adolescent adherence to weekly iron and/or folic acid supplements in a setting of low secondary school attendance. METHODS: Taped in-depth interviews were conducted with participants in a randomised, controlled, periconceptional iron supplementation trial for young nulliparous women living in a rural, malaria endemic region of Burkina Faso...
March 14, 2018: Reproductive Health
Qian Liu, Yang Yang, Xiaoxue Mei, Bingfeng Liu, Chuan Chen, Defeng Xing
Ferric iron can affect the current generation of microbial electrochemical system (MES); however, how it influences microbial biofilm formation and metabolic activity has not been reported. Here, we describe the response of microbial electrode biofilm communities to insoluble ferric iron (Fe3+ ) at different concentrations in microbial fuel cells (MFCs). Insoluble ferric iron (200μM) improved electrochemical activity of the MFCs microbial biofilms during start-up and resulted in a higher maximum power density of 0...
March 11, 2018: Science of the Total Environment
Selin Elmaoğulları, Zeyra Aycan
Abnormal uterine bleeding (AUB) is the major gynecologic complaint of adolescents admitting to hospital. Heavy menstrual bleeding (HMB) is the most common clinical presentation of AUB. Anovulatory cycles owing to immature hypothalamic-pituitary-ovarian axis is the leading etiology of HMB and there is an accompanying bleeding disorder in almost %20 of patients with HMB. Additionally, endocrine disorders such as hypothyroidism, hyperprolactinemia and polycystic ovary syndrome (PCOS) are possible causes of AUB...
February 28, 2018: Journal of Clinical Research in Pediatric Endocrinology
David J Eve, George Steiner, Ajay Mahendrasah, Paul R Sanberg, Crupa Kurien, Avery Thomson, Cesar V Borlongan, Svitlana Garbuzova-Davis
Blood-spinal cord barrier (BSCB) alterations, including capillary rupture, have been demonstrated in animal models of amyotrophic lateral sclerosis (ALS) and ALS patients. To date, treatment to restore BSCB in ALS is underexplored. Here, we evaluated whether intravenous transplantation of human bone marrow CD34+ (hBM34+ ) cells into symptomatic ALS mice leads to restoration of capillary integrity in the spinal cord as determined by detection of microhemorrhages. Three different doses of hBM34+ cells (5 × 104 , 5 × 105 or 1 × 106 ) or media were intravenously injected into symptomatic G93A SOD1 mice at 13 weeks of age...
February 13, 2018: Oncotarget
Lesley J Scott
Intravenous ferric carboxymaltose (Ferinject® ; Injectafer® ) is a colloidal solution of nanoparticles which consist of a polynuclear iron (III)-(oxyhydr)oxide core stabilized by carboxymaltose and may be given as a single high-dose, 15-min infusion. This article reviews the clinical use of ferric carboxymaltose in various patient populations with iron deficiency (ID) [± anaemia] and briefly summarizes its pharmacological properties. Based on extensive experience in the clinical trial and real-world settings, ferric carboxymaltose is an effective and generally well tolerated treatment for rapidly replenishing iron stores and correcting anaemia in patients with ID (± anaemia) of various aetiologies, including patients with chronic heart failure (CHF), chronic kidney disease, inflammatory bowel disease or perioperative anaemia, and women with ID during pregnancy, postpartum or associated with heavy uterine bleeding...
March 2018: Drugs
Kenji Sakamoto, Taishi Suzuki, Kosuke Takahashi, Takumi Koguchi, Tasuku Hirayama, Asami Mori, Tsutomu Nakahara, Hideko Nagasawa, Kunio Ishii
Excitoneurotoxicity is regarded as one of the mechanisms of the death of retinal ganglion cells induced by retinal central artery occlusion and glaucoma. Oxidative stress is at least in part involved in excitoneurotoxicity. Fenton reaction, which is catalyzed by Fe2+ , is known to cause formation of hydroxyl radical, one of reactive oxygen species, suggesting that chelation of iron may be protective against excitoneurotoxicity. In the present study, we histologically evaluated whether zinc-deferoxamine (Zn-DFO) and deferasirox (DFX), common iron-chelating agents, were protective against N-methyl-D-aspartate (NMDA)-induced retinal injury in the rat in vivo...
March 9, 2018: Experimental Eye Research
Josep Estadella, Laura Villamarín, Anna Feliu, Josep Perelló, Joaquim Calaf
Iron deficiency anemia is the most frequent cause of anemia world-wide and is a very common disorder in daily medical practice. Heavy menstrual bleeding (menorrhagia) and pregnancy and delivery can cause significant iron loss leading to severe anemia The aim of the present study was to characterize the population requiring intravenous iron and identify whether gynecological and obstetric iron loss are frequent indications for treatment. MATERIAL AND METHODS: Restrospective, single center study performed in a tertiary level university hospital from January 2014 to December 2016...
March 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"