keyword
MENU ▼
Read by QxMD icon Read
search

Iron treatment

keyword
https://www.readbyqxmd.com/read/28811946/are-all-mutations-the-same-a-rare-case-report-of-coexisting-mutually-exclusive-kras-and-braf-mutations-in-a-patient-with-metastatic-colon-adenocarcinoma
#1
Anusha Vittal, Akshay Middinti, Anup Kasi Loknath Kumar
29-year-old Hispanic woman presented to the clinic with complaints of abdominal pain, nausea, fatigue, and constipation. Laboratory tests indicated the presence of iron deficiency anemia and transaminitis. Imaging evaluation revealed marked hepatomegaly with multiple hepatic metastases and pelvic lymphadenopathy. Biopsy of the hepatic lesions showed adenocarcinoma positive for pan-cytokeratin, CMA5.2, villin, and CDX2. She was positive for tumor markers CA 19-9, CA-125, and CEA. Upon further evaluation, she was found to have colorectal cancer positive for KRAS and BRAF mutations...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28811642/octahedron-iron-oxide-nanocrystals-prohibited-clostridium-difficile-spore-germination-and-attenuated-local-and-systemic-inflammation
#2
Wei-Ting Lee, Ya-Na Wu, Yi-Hsuan Chen, Shang-Rung Wu, Tsai-Miao Shih, Tsung-Ju Li, Li-Xing Yang, Chen-Sheng Yeh, Pei-Jane Tsai, Dar-Bin Shieh
Clinical management of Clostridium difficile infection is still far from satisfactory as bacterial spores are resistant to many chemical agents and physical treatments. Certain types of nanoparticles have been demonstrated to exhibit anti-microbial efficacy even in multi-drug resistance bacteria. However, most of these studies failed to show biocompatibility to the mammalian host cells and no study has revealed in vivo efficacy in C. difficile infection animal models. The spores treated with 500 µg/mL Fe3-δO4 nanoparticles for 20 minutes, 64% of the spores were inhibited from transforming into vegetative cells, which was close to the results of the sodium hypochlorite-treated positive control...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811344/the-capacity-of-mycobacterium-tuberculosis-to-survive-iron-starvation-might-enable-it-to-persist-in-iron-deprived-microenvironments-of-human-granulomas
#3
Krishna Kurthkoti, Hamel Amin, Mohlopheni J Marakalala, Saleena Ghanny, Selvakumar Subbian, Alexandra Sakatos, Jonathan Livny, Sarah M Fortune, Michael Berney, G Marcela Rodriguez
This study was conducted to investigate the role of iron deprivation in the persistence of Mycobacterium tuberculosis We present evidence of iron restriction in human necrotic granulomas and demonstrate that under iron starvation M. tuberculosis persists, refractive to antibiotics and capable of restarting replication when iron is made available. Transcriptomics and metabolomic analyses indicated that the persistence of M. tuberculosis under iron starvation is dependent on strict control of endogenous Fe utilization and is associated with upregulation of pathogenicity and intrinsic antibiotic resistance determinants...
August 15, 2017: MBio
https://www.readbyqxmd.com/read/28811181/beneficial-effects-of-postnatal-choline-supplementation-on-long-term-neurocognitive-deficit-resulting-from-fetal-neonatal-iron-deficiency
#4
Bruce C Kennedy, Phu V Tran, Maulika Kohli, Jamie J Maertens, Jonathan C Gewirtz, Michael K Georgieff
Early-life iron deficiency is a common nutrient condition worldwide and can result in cognitive impairment in adulthood despite iron treatment. In rodents, prenatal choline supplementation can diminish long-term hippocampal gene dysregulation and neurocognitive deficits caused by iron deficiency. Since fetal iron status is generally unknown in humans, we determined whether postnatal choline supplementation exerts similar beneficial effects. Male rat pups were made iron deficient (ID) by providing pregnant and nursing dams an ID diet (3-6ppm Fe) from gestational day (G) 3 through postnatal day (P) 7, and an iron-sufficient (IS) diet (200ppm Fe) thereafter...
August 12, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28809446/deferasirox-for-managing-iron-overload-in-people-with-thalassaemia
#5
REVIEW
Claudia Bollig, Lisa K Schell, Gerta Rücker, Roman Allert, Edith Motschall, Charlotte M Niemeyer, Dirk Bassler, Joerg J Meerpohl
BACKGROUND: Thalassaemia is a hereditary anaemia due to ineffective erythropoiesis. In particular, people with thalassaemia major develop secondary iron overload resulting from regular red blood cell transfusions. Iron chelation therapy is needed to prevent long-term complications.Both deferoxamine and deferiprone are effective; however, a review of the effectiveness and safety of the newer oral chelator deferasirox in people with thalassaemia is needed. OBJECTIVES: To assess the effectiveness and safety of oral deferasirox in people with thalassaemia and iron overload...
August 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28805705/changes-of-bone-related-minerals-during-denosumab-administration-in-post-menopausal-osteoporotic-patients
#6
Takako Suzuki, Yukio Nakamura, Hiroyuki Kato
OBJECTIVES: This retrospective study included 21 patients with primary osteoporosis who were treated with the anti-resorption drug, denosumab. To date, there has been no detailed report on the changes of bone-related minerals after anti-resorption drug therapy. METHODS: Twenty-one post-menopausal females were retrospectively enrolled. Serum zinc (Zn), magnesium (Mg), iron (Fe), copper (Cu), grip strength, and estimated glomerular filtration rate (eGFR) were examined at one week and 1, 2, 4, 6, 8, 10, and 12 months...
August 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28804670/synthesis-and-characterization-of-mixed-iron-manganese-oxide-nanoparticles-and-their-application-for-efficient-nickel-ion-removal-from-aqueous-samples
#7
Alessandro Buccolieri, Antonio Serra, Giuseppe Maruccio, Anna Grazia Monteduro, Sanosh Kunjalukkal Padmanabhan, Antonio Licciulli, Valentina Bonfrate, Luca Salvatore, Daniela Manno, Lucio Calcagnile, Gabriele Giancane
Mixed iron-manganese oxide nanoparticles, synthesized by a simple procedure, were used to remove nickel ion from aqueous solutions. Nanostructures, prepared by using different weight percents of manganese, were characterized by transmission electron microscopy, selected area diffraction, X-ray diffraction, Raman spectroscopy, and vibrating sample magnetometry. Adsorption/desorption isotherm curves demonstrated that manganese inclusions enhance the specific surface area three times and the pores volume ten times...
2017: Journal of Analytical Methods in Chemistry
https://www.readbyqxmd.com/read/28803519/a-case-report-of-benzocaine-induced-methemoglobinemia
#8
Chaundra R Sewell, Michael P Rivey
Methemoglobinemia is a serious medical condition characterized by the disrupted binding of oxygen to iron on hemoglobin, with a consequent impaired oxygen delivery to body tissues. Various drugs including the local anesthetics such as benzocaine can cause acquired methemoglobinemia. The reported case describes methemoglobinemia that occurred in association with the use of topical benzocaine spray and lozenges in a previously healthy 51-year-old female who had undergone colon surgery to remove a bleeding polyp...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28801773/growth-performance-mineral-digestibility-and-blood-characteristics-of-ostriches-receiving-drinking-water-supplemented-with-varying-levels-of-chelated-trace-mineral-complex
#9
Hossein Seyfori, Hossein Ali Ghasemi, Iman Hajkhodadadi, Mohammad Hassan Nazaran, Maryam Hafizi
The effects of water supplementation of chelated trace minerals (CTM, which is named Bonzaplex designed with chelate compounds technology) on growth performance, apparent total tract digestibility (ATTD) of minerals, and some blood metabolites, TM, and antioxidant enzyme values in African ostriches were investigated from 8 to 12 months of age. A total of 20 8-month-old ostriches (five birds in five replicate pens) was randomly allocated into one of the following four treatments: (1) control (basal diet + tap water), (2) low CTM (basal diet +100 mg/bird/day CTM powder in tap water), (3) medium CTM (basal diet +1 g/bird/day CTM powder in tap water), and (4) high CTM (basal diet +2 g/bird/day CTM powder in tap water)...
August 11, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28801072/irinotecan-chemotherapy-induced-intestinal-oxidative-stress-underlying-causes-of-disturbed-mucosal-water-and-electrolyte-transport
#10
Kaïs Rtibi, Slimen Selmi, Dhekra Grami, Hichem Sebai, Mohamed Amri, Lamjed Marzouki
Irinotecan, a chemotherapy drug, can cause acute diarrhea immediately after administration. Hence, the present study was designed to investigate the gastrointestinal (GI) disturbances after an intraperitoneal (IP) administration of irinotecan in rats.Twenty Wistar rats were separated into two groups of ten. Group A was considered as a control group (NaCl, 0.9%). Group B was treated with irinotecan at a single dose of 200mgkg(-1). The rats were observed for defecation. For the enteropooling test, the animals were sacrificed by decapitation 1h post-treatment...
July 23, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28799940/experimental-study-on-treating-agate-dyeing-wastewater-with-sulfate-reducing-bacteria-strengthening-peanut-shells-and-scrap-iron
#11
Junzhen Di, Mingxin Wang
To solve the problems of high concentrations of Cr(6+), SO4(2-) and H(+) in agate dyeing industrial wastewater and heavy pollution and high treating cost, single-factor and orthogonal experiments were conducted to determine the optimum particle size, the ratio of adsorbents dosing and hydraulic retention time based on peanut shells and scrap iron. Experiments, using five dynamic columns filled with the peanut shells, scrap iron and sulfate-reducing bacteria (SRB), were also conducted to determine the effect and mechanism of treating the wastewater...
August 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28799938/improvement-of-phosphorus-removal-by-calcium-addition-in-the-iron-electrocoagulation-process
#12
I Mishima, M Hama, Y Tabata, J Nakajima
Small-scale wastewater treatment plants (SWTPs) are widely used as decentralized wastewater treatment systems in sparsely populated areas of Japan. Iron electrolysis, an electrocoagulation technology, is installed in these SWTPs for phosphorus removal. Phosphorus can be removed via the formation of an insoluble compound containing phosphate and iron, such as FePO4; however, it was necessary to determine the conditions under which phosphorus can be effectively and stably removed in actual SWTPs. According to previous studies using iron compounds, improved phosphorus removal was obtained by Ca addition...
August 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28799929/scaling-up-of-a-zero-valent-iron-packed-anaerobic-reactor-for-textile-dye-wastewater-treatment-a-potential-technology-for-on-site-upgrading-and-rebuilding-of-traditional-anaerobic-wastewater-treatment-plant
#13
Yang Li, Jingxin Zhang, Yaobin Zhang, Xie Quan
Anaerobic digestion (AD) is a cost-effective technology for the treatment of textile dye wastewater with clear environmental benefits. However, the need to improve process feasibility of high treatment efficiency as well as to shorten hydraulic retention time has raised interest on several intensification techniques. Zero valent iron (ZVI) packed anaerobic digesters have the potential to become an on-site upgrading wastewater treatment technology through building a ZVI bed in a traditional AD plant. However, the experiences and knowledge of scale-up are limited...
August 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28797164/universal-surface-engineering-of-transition-metals-for-superior-electrocatalytic-hydrogen-evolution-in-neutral-water
#14
Bo You, Xuan Liu, Guoxiang Hu, Sheraz Gul, Junko Yano, De-En Jiang, Yujie Sun
The development of low-cost hybrid water splitting-biosynthetic systems that mimic natural photosynthesis to achieve solar-to-chemical conversion is of great promise for future energy demands, but often limited by the kinetically sluggish H2 evolu-tion reaction (HER) on the surface of nonprecious transition metal catalysts in neutral media. It is thus highly desirable to rationally tailor the reaction interface to boost the neutral HER catalytic kinetics. Herein, we report a general surface nitro-gen modification of diverse transition metals (e...
August 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28795681/-research-progress-of-iron-metabolism-in-critical-ill-patients
#15
Ling Xie, Shengnan Wang, Suyue Pan
Iron is an essential nutrient element for human, but has potential toxicity. Under physiological conditions, the processes of iron absorption, transportation, cellular uptake and utilization, storage, release, excretion as well as regulation of iron metabolism maintain the iron homeostasis. However under pathological conditions, the iron metabolism changes and is associated with the pathological states. In order to realize the relationship between the critical illness status and the iron metabolism, we start with an analysis of the basic processes of iron metabolism in human and the toxicity of iron, followed by summary on the alteration of iron metabolism in the settings of pathological conditions, such as inflammation, infection and anemia, which often occur in critical illness...
August 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28793991/trial-of-ready-to-use-supplemental-food-and-corn-soy-blend-in-pregnant-malawian-women-with-moderate-malnutrition-a-randomized-controlled-clinical-trial
#16
Meghan Callaghan-Gillespie, Andrew A Schaffner, Patsy Garcia, Jocelyn Fry, Rachael Eckert, Shirin Malek, Indi Trehan, Chrissie Thakwalakwa, Kenneth M Maleta, Mark J Manary, Peggy C Papathakis
Background: Malnutrition during pregnancy in sub-Saharan Africa is associated with poor birth outcomes.Objective: This study compared maternal and offspring anthropometry for moderately malnourished pregnant women receiving ready-to-use supplemental food (RUSF), a fortified corn-soy blend (CSB+) with a daily multiple micronutrient antenatal supplement [United Nations International Multiple Micronutrient Preparation (UNIMMAP)], or standard of care comprising CSB+ and iron and folic acid (IFA).Design: A single-blind randomized controlled clinical trial was conducted in southern Malawi among 1828 pregnant women with moderate malnutrition, defined as a midupper arm circumference (MUAC) ≥20...
August 9, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28793778/peroxiredoxin-2-a-novel-regulator-of-iron-homeostasis-in-ineffective-erythropoiesis
#17
Alessandro Matte, Luigia De Falco, Enrica Federti, Anna Cozzi, Achille Iolascon, Sonia Levi, Narla Mohandas, Alberto Zamo, Mariasole Bruno, Christophe Leboeuf, Anne Janin, Angela Siciliano, Thomas Ganz, Giorgia Federico, Francesca Carlomagno, Sebastian Mueller, Ines Silva, Carmine Carbone, Davide Melisi, D W Kim, Soo Young Choi, Lucia DE Franceschi
AIMS: Iron-overload (IO) is a life-threatening complication of chronic hemolytic disorders such as β-thalassemia. IO results in severe cellular oxidative damage, leading to organ failure. Peroxiredoxin-2 (Prx2), a typical 2-cysteine-(Cys)-peroxiredoxin, is an important component of cyto-protective system, but its response to IO is still to be fully defined. RESULTS: We studied the effects of IO on Prx2-knockout mice (Prx2-/-). The absence of Prx2 enhanced toxicity due to IO on erythropoiesis...
August 10, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28792693/serum-hepcidin-levels-in-multiple-myeloma
#18
Manolov Victor, Hadjiev Evgeniy, Tzvetkova Gergana, Petrova Julia, Vasilev Vasil, Marinov Borislav, Bogov Ivo, Gramatikova Zlatina, Tzatchev Kamen
BACKGROUND: Multiple myeloma (MM) is a malignant disease with a 10% frequency among all haematology neoplasms. It is characterized by clone proliferation of plasmatic cells in bone marrow, monoclonal gammopathy, and anemia, hypercalcemia, and kidney failure and bone lesions. IL-6 is an inflammatory cytokine, potential growth factor for myeloma cells, as elevated serum levels are connected with poor disease prognosis. IL-6 modulates many gene transcriptions, encoding synthesis of acute phase proteins, including C-reactive protein (CRP) and hepcidin...
July 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28791836/in-vivo-effects-of-curcumin-and-deferoxamine-in-experimental-endometriosis
#19
Gulnur Kizilay, Yesim Hulya Uz, Gulay Seren, Enis Ulucam, Ali Yilmaz, Ziya Cukur, Umit Ali Kayisli
BACKGROUND: Endometriosis is one of the most common chronic gynecological diseases. OBJECTIVES: The aim of the study was to examine the effects of curcumin and/or deferoxamine on cell proliferation in a rat model of endometriosis. MATERIAL AND METHODS: Thirty female 12-week-old albino Wistar rats, weighing 200-250 g, were used in this study. All the rats underwent ovariectomy and 0.1-mg β-estradiol 17-valerate pellets were placed intraperitoneally...
March 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28789716/in-vitro-antileishmanial-activity-and-iron-superoxide-dismutase-inhibition-of-arylamine-mannich-base-derivatives
#20
Alvaro Martin-Montes, Mery Santivañez-Veliz, Elsa Moreno-Viguri, Rubén Martín-Escolano, Carmen Jiménez-Montes, Catalina Lopez-Gonzalez, Clotilde Marín, Carmen Sanmartín, Ramón Gutiérrez Sánchez, Manuel Sánchez-Moreno, Silvia Pérez-Silanes
Leishmaniasis is one of the world's most neglected diseases, and it has a worldwide prevalence of 12 million. There are no effective human vaccines for its prevention, and treatment is hampered by outdated drugs. Therefore, research aiming at the development of new therapeutic tools to fight leishmaniasis remains a crucial goal today. With this purpose in mind, we present 20 arylaminoketone derivatives with a very interesting in vitro and in vivo efficacy against Trypanosoma cruzi that have now been studied against promastigote and amastigote forms of Leishmania infantum, Leishmania donovani and Leishmania braziliensis strains...
August 9, 2017: Parasitology
keyword
keyword
119948
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"