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https://www.readbyqxmd.com/read/28436827/reductive-precipitation-of-sulfate-and-soluble-fe-iii-by-desulfovibrio-vulgaris-electron-donor-regulates-intracellular-electron-flow-and-nano-fes-crystallization
#1
Chen Zhou, Yun Zhou, Bruce E Rittmann
Fully understanding the metabolism of SRB provides fundamental guidelines for allowing the microorganisms to provide more beneficial services in water treatment and resource recovery. The electron-transfer pathway of sulfate respiration by Desulfovibrio vulgaris is well studied, but still partly unresolved. Here we provide deeper insight by comprehensively monitoring metabolite changes during D. vulgaris metabolism with two electron donors, lactate and pyruvate, in presence or absence of citrate-chelated soluble Fe(III) as an additional competing electron acceptor...
April 19, 2017: Water Research
https://www.readbyqxmd.com/read/28436136/effects-of-ferric-carboxymaltose-on-hospitalisations-and-mortality-rates-in-iron-deficient-heart-failure-patients-an-individual-patient-data-meta-analysis
#2
Stefan D Anker, Bridget-Anne Kirwan, Dirk J van Veldhuisen, Gerasimos Filippatos, Josep Comin-Colet, Frank Ruschitzka, Thomas F Lüscher, Gregory P Arutyunov, Michael Motro, Claudio Mori, Bernard Roubert, Stuart J Pocock, Piotr Ponikowski
AIMS: Iron deficiency (ID) is a common co-morbidity in patients with heart failure (HF) and has been suggested to be associated with poor prognosis. Recently completed double-blind randomised controlled trials (RCTs) studying HF patients with ID have shown improvements in functional capacity, symptoms and quality of life when treated with i.v. ferric carboxymaltose (FCM). This individual patient data meta-analysis investigates the effect of FCM vs. placebo on recurrent hospitalisations and mortality in HF patients with ID...
April 24, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28435981/-iron-metabolism-and-neonatal-hypoxic-ischemic-brain-damage
#3
Kai-Yu Xu, Fan Li
Iron is an essential element for nervous system development, and maintaining a normal iron level in nervous system is controlled by multiple factors. Recent studies reported that iron dysregulation and the following iron metabolic pathways played an important role in hypoxic ischemic brain damage (HIBD) in neonates. Circulatory iron level is altered after hypoxia-ischemia exposure, which may cause abnormal iron deposition in the nervous system followed by neuronal injury. Finding the causing factors for abnormal iron metabolism after hypoxia-ischemia exposure, as well as understanding the mechanisms how iron metabolism contributes to HIBD, will shed lights on HIBD prevention and treatment...
April 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28435255/recent-developments-in-the-nanostructured-materials-functionalized-with-ruthenium-complexes-for-targeted-drug-delivery-to-tumors
#4
REVIEW
Prakash Thangavel, Buddolla Viswanath, Sanghyo Kim
In recent years, the field of metal-based drugs has been dominated by other existing precious metal drugs, and many researchers have focused their attention on the synthesis of various ruthenium (Ru) complexes due to their potential medical and pharmaceutical applications. The beneficial properties of Ru, which make it a highly promising therapeutic agent, include its variable oxidation states, low toxicity, high selectivity for diseased cells, ligand exchange properties, and the ability to mimic iron binding to biomolecules...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28434208/dietary-interventions-for-adults-with-chronic-kidney-disease
#5
REVIEW
Suetonia C Palmer, Jasjot K Maggo, Katrina L Campbell, Jonathan C Craig, David W Johnson, Bernadet Sutanto, Marinella Ruospo, Allison Tong, Giovanni Fm Strippoli
BACKGROUND: Dietary changes are routinely recommended in people with chronic kidney disease (CKD) on the basis of randomised evidence in the general population and non-randomised studies in CKD that suggest certain healthy eating patterns may prevent cardiovascular events and lower mortality. People who have kidney disease have prioritised dietary modifications as an important treatment uncertainty. OBJECTIVES: This review evaluated the benefits and harms of dietary interventions among adults with CKD including people with end-stage kidney disease (ESKD) treated with dialysis or kidney transplantation...
April 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28433930/environmental-electrokinetics-for-a-sustainable-subsurface
#6
REVIEW
A T Lima, A Hofmann, D Reynolds, C J Ptacek, P Van Cappellen, L M Ottosen, S Pamukcu, A Alshawabekh, D M O'Carroll, C Riis, E Cox, D B Gent, R Landis, J Wang, A I A Chowdhury, E L Secord, A Sanchez-Hachair
Soil and groundwater are key components in the sustainable management of the subsurface environment. Source contamination is one of its main threats and is commonly addressed using established remediation techniques such as in-situ chemical oxidation (ISCO), in-situ chemical reduction (ISCR; most notably using zero-valent iron [ZVI]), enhanced in-situ bioremediation (EISB), phytoremediation, soil-washing, pump-and-treat, soil vapour extraction (SVE), thermal treatment, and excavation and disposal. Decades of field applications have shown that these techniques can successfully treat or control contaminants in higher permeability subsurface materials such as sands, but achieve only limited success at sites where low permeability soils, such as silts and clays, prevail...
April 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28433920/proteomic-analysis-of-sockeye-salmon-serum-as-a-tool-for-biomarker-discovery-and-new-insight-into-the-sublethal-toxicity-of-diluted-bitumen
#7
Sarah L Alderman, Laura A Dindia, Christopher J Kennedy, Anthony P Farrell, Todd E Gillis
Pipelines carrying diluted bitumen (dilbit) from Canada's oil sands traverse North America, including the freshwater habitat of Pacific salmon, posing a risk of environmental release and aquatic exposure. Swimming performance is impacted in juvenile sockeye (Oncorhynchus nerka) exposed to dilbit; therefore biomarkers of dilbit exposure will be valuable for monitoring at-risk salmon stocks. This study characterized changes in the serum proteome of sockeye exposed to a sub-lethal and environmentally relevant concentration of dilbit using isobaric tags for relative and absolute quantitation (iTRAQ), and included a range of experimental conditions to permit identification of biomarkers that are robust across time (1 and 4wk) and exercise level (at rest and following a swim test)...
April 12, 2017: Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics
https://www.readbyqxmd.com/read/28433798/randomized-trial-of-early-erythropoietin-supplementation-after-preterm-birth-iron-metabolism-and-outcome
#8
O M Peltoniemi, E Anttila, T Kaukola, G Buonocore, M Hallman
BACKGROUND: Excess of iron and oxidant injury shortly after birth may be associated with neonatal morbidities in preterm infants. AIMS: The aim was to determine whether administration of erythropoietin without iron supplementation decreases iron load and morbidity. STUDY DESIGN AND SUBJECTS: In a randomized trial, we administered erythropoietin (EPO 250IU/kg daily during the first 6days of life) or placebo to 39 preterm infants (BW 700-1500g, GA≤30...
April 20, 2017: Early Human Development
https://www.readbyqxmd.com/read/28433108/genetic-and-environmental-modifiers-of-wilson-disease
#9
Valentina Medici, Karl-Heinz Weiss
Wilson disease (WD) is characterized by remarkable variety in its phenotypic presentation. Patients with WD can present with hepatic, neurologic, and psychiatric symptoms combined in different and unpredictable ways. Importantly, no convincing phenotype-genotype correlation has ever been identified, opening the possibility that other genes, aside from ATPase copper-transporting beta (ATP7B), are involved in the pathogenesis of this condition. In addition, modifier genes, or genes that can affect the expression of other genes, may be involved...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28432821/addition-of-hydrogen-peroxide-to-groundwater-with-natural-iron-induces-water-disinfection-by-photo-fenton-at-circumneutral-ph-and-other-photochemical-events
#10
Héctor Mario Gutiérrez-Zapata, John Jairo Alvear-Daza, Julián Andrés Rengifo-Herrera, Janeth Sanabria
Samples of natural groundwater (with low turbidity, neutral pH and 0.3 mg L(-1) iron concentration) inoculated with Escherichia coli K-12, were exposed to simulated solar light both in the presence and absence 10 mg L(-1) of H2 O2. Results demonstrated that the viability of E. coli (by DVC-FISH) was grounded to zero after 360 min of irradiation. This abatement could be caused by the oxidative stress induced by •OH radicals or another photo-induced reactive oxygen species. Two 2(3) factorial experimental designs enabled the evaluation of the effects of chemical factors on the inactivation of E...
April 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28432630/the-influence-of-restoration-measures-on-phosphorus-internal-loading-from-the-sediments-of-a-hypereutrophic-lake
#11
Katarzyna Kowalczewska-Madura, Renata Dondajewska, Ryszard Gołdyn, Stanisław Podsiadłowski
Uzarzewskie Lake was a hypereutrophic, dimictic lake characterized by low water transparency, high chlorophyll-a concentration and intense phytoplankton blooms; thus, restoration treatment was started. A chemical treatment, based on phosphorus inactivation with small doses of iron sulphate, was undertaken in 2006-2007. Nitrate-rich groundwater flowing from seepage springs was directed into the lake hypolimnion to increase redox potential since 2008. Phosphorus internal loading was reduced by more than 80% as a result of restoration treatment...
April 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28431461/impact-of-superparamagnetic-iron-oxide-nanoparticles-on-vocal-fold-fibroblasts-cell-behavior-and-cellular-iron-kinetics
#12
Marina Pöttler, Anna Fliedner, Eveline Schreiber, Christina Janko, Ralf Philipp Friedrich, Christopher Bohr, Michael Döllinger, Christoph Alexiou, Stephan Dürr
PURPOSE: The voice is the most important instrument of communication. Tissue defects in the vocal fold (VF) area lead to serious reduction in quality of life, but thus far, no satisfactory VF implant exists. Therefore, we aim to establish a functional VF implant in a rabbit model by magnetic tissue engineering (MTE) using superparamagnetic iron oxide nanoparticles (SPION). Hence, iron quantification over time as well as cell behavior studies upon SPION treatment are of great importance...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28431390/sulfonamides-photoassisted-oxidation-treatments-catalyzed-by-ilmenite
#13
P García-Muñoz, G Pliego, J A Zazo, A Bahamonde, J A Casas
This work assesses the feasibility of several advanced oxidation processes (CWPO Catalytic Wet Peroxide Oxidation), Photocatalysis and their combination (CWPO-Photoassisted process) for sulfonamide antibiotic degradation. Raw ilmenite was used as catalyst in both processes, because of the presence of iron and titanium in its structure. Despite both treatments allowed reaching a total starting antibiotic depletion working at pH0 = 3 and T0 = 30 °C within 30 min reaction time, significant differences were observed in terms of mineralization...
April 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/28431372/down-flow-fixed-structured-bed-reactor-an-innovative-reactor-configuration-applied-to-acid-mine-drainage-treatment-and-metal-recovery
#14
Leandro Augusto Gouvêa de Godoi, Eugenio Foresti, Márcia Helena Rissato Zamariolli Damianovic
A down-flow fixed-structured bed reactor (DFSBR) was operated for 277 days treating a mixture of synthetic substrates simulating an iron-rich acid mine drainage (AMD) and the soluble fraction of a sugarcane vinasse. The synthetic sugarcane vinasse was used as electron donor for biological sulfate-reduction, resulting in influent chemical oxygen demand (COD) close to 4000 mg L(-1) and volumetric organic loading rate of 4.8 g L(-1)d(-1). The influent sulfate concentration was kept close to 2000 mg L(-1) (volumetric sulfate loading rate of 2...
April 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28431327/dendrimer-conjugated-iron-oxide-nanoparticles-as-stimuli-responsive-drug-carriers-for-thermally-activated-chemotherapy-of-cancer
#15
Saumya Nigam, Dhirendra Bahadur
In recent years, functional nanomaterials have found an appreciable place in the understanding and treatment of cancer. This work demonstrates the fabrication and characterization of a new class of cationic, biocompatible, peptide dendrimers, which were then used for stabilizing and functionalizing magnetite nanoparticles for combinatorial therapy of cancer. The synthesized peptide dendrimers have an edge over the widely used PAMAM dendrimers due to better biocompatibility and negligible cytotoxicity of their degradation products...
April 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28430694/iron-loading-exaggerates-the-inflammatory-response-to-the-toll-like-receptor-4-ligand-lipopolysaccharide-by-altering-mitochondrial-homeostasis
#16
Konrad Hoeft, Donald B Bloch, Jan A Graw, Rajeev Malhotra, Fumito Ichinose, Aranya Bagchi
BACKGROUND: Perioperative and critically ill patients are often exposed to iron (in the form of parenteral-iron administration or blood transfusion) and inflammatory stimuli, but the effects of iron loading on the inflammatory response are unclear. Recent data suggest that mitochondrial reactive oxygen species have an important role in the innate immune response and that increased mitochondrial reactive oxygen species production is a result of dysfunctional mitochondria. We tested the hypothesis that increased intracellular iron potentiates lipopolysaccharide-induced inflammation by increasing mitochondrial reactive oxygen species levels...
April 21, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28430292/failure-of-the-vascular-hypothesis-of-multiple-sclerosis-in-a-rat-model-of-chronic-cerebrospinal-venous-insufficiency
#17
Maha M A Zakaria, Shahira Y Mikhael, Azza K Abu Hussein, Rania A Salah El-Din, Hany W Abd El-Malak, Iman H Hewedi, Hany S Nadim
<i>Chronic cerebrospinal venous insufficiency (CCSVI) is a series of stenotic malformations in the cerebrospinal venous outflow routes, which is postulated to cause multiple sclerosis (MS). The hypotheses assumed that CCSVI leads to iron deposition which triggers inflammation and demyelination in MS. Invasive endovascular treatment of CCSVI was initiated based on the previous theory. The present study was designed to validate this hypothesis using a rat model of CCSVI. Bilateral jugular vein ligation (JVL) was performed on female albino rats (n = 15), and sham-operated rats (n = 15) were used as a control group...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28429247/a-review-of-the-novel-application-and-potential-adverse-effects-of-proton-pump-inhibitors
#18
REVIEW
Li-Yuan Yu, Lu-Ning Sun, Xue-Hui Zhang, Yue-Qi Li, Lei Yu, Zi-Qing-Yun Yuan, Ling Meng, Hong-Wen Zhang, Yong-Qing Wang
Proton pump inhibitors (PPIs) are known as a class of pharmaceutical agents that target H(+)/K(+)-ATPase, which is located in gastric parietal cells. PPIs are widely used in the treatment of gastric acid-related diseases including peptic ulcer disease, erosive esophagitis and gastroesophageal reflux disease, and so on. These drugs present an excellent safety profile and have become one of the most commonly prescribed drugs in primary and specialty care. Except for gastric acid-related diseases, PPIs can also be used in the treatment of Helicobacter pylori infection, viral infections, respiratory system diseases, cancer and so on...
April 20, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28428976/sem-and-afm-studies-of-two-phase-magnetic-alkali-borosilicate-glasses
#19
N Andreeva, M Tomkovich, A Naberezhnov, B Nacke, A Filimonov, O Alekseeva, P Vanina, V Nizhankovskii
The morphology and composition of four types of two-phase alkali borosilicate glasses with magnetic atoms prepared by inductive melting have been studied. The results of scanning electron microscopy point to uniform distribution of Na, Si, and O atoms in these samples while magnetic iron atoms form ball-shaped agglomerates. The magnetic properties of these agglomerates have been confirmed by magnetic force microscopy. Atomic force microscopy had shown that in these samples two different morphological structures, drop-like and dendrite net, are formed...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28427888/dopamine-elevates-intracellular-zinc-concentration-in-cultured-rat-embryonic-cortical-neurons-through-the-camp-nitric-oxide-signaling-cascade
#20
Hui-Hsing Hung, Lung-Sen Kao, Pei-Shan Liu, Chien-Chang Huang, De-Ming Yang, Chien-Yuan Pan
Zinc ion (Zn(2+)), the second most abundant transition metal after iron in the body, is essential for neuronal activity and also induces toxicity if the concentration is abnormally high. Our previous results show that exposure of cultured cortical neurons to dopamine elevates intracellular Zn(2+) concentrations ([Zn(2+)]i) and induces autophagosome formation but the mechanism is not clear. In this study, we characterized the signaling pathway responsible for the dopamine-induced elevation of [Zn(2+)]i and the effect of [Zn(2+)]i in modulating the autophagy in cultured rat embryonic cortical neurons...
April 17, 2017: Molecular and Cellular Neurosciences
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