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Fluorescent guided surgery

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https://www.readbyqxmd.com/read/29451953/using-quantitative-tissue-phenotype-to-assess-the-margins-of-surgical-samples-from-a-pan-canadian-surgery-study
#1
Martial Guillaud, Calum E MacAulay, Kenneth W Berean, Martin Bullock, Kelly Guggisberg, Hagen Klieb, Lakshmi Puttagunta, Carla Penner, Keith Kwan, Miriam P Rosin, Catherine F Poh
BACKGROUND: The purpose of this study was to use quantitative tissue phenotype (QTP) to assess the surgical margins to examine if a fluorescence visualization-guided surgical approach produces a shift in the surgical field by sparing normal tissue while catching high-risk tissue. METHODS: Using our QTP to calculate the degree of nuclear chromatin abnormalities, Nuclear Phenotypic Score (NPS), we analyzed 1290 biopsy specimens taken from surgical samples of 248 patients enrolled in the Efficacy of Optically-guided Surgery in the Management of Early-staged Oral Cancer (COOLS) trial...
February 16, 2018: Head & Neck
https://www.readbyqxmd.com/read/29450654/visualizing-protoporphyrin-ix-formation-in-the-dura-tail-of-meningiomas-by-mass-spectrometry-imaging
#2
Benjamin Brokinkel, Sabrina Kröger, Volker Senner, Astrid Jeibmann, Uwe Karst, Walter Stummer
BACKGROUND: The advantages of 5-aminolevulinacid (5-ALA)-induced fluorescence-guided surgery in meningiomas are increasingly discussed. In this context, despite detectable tumor tissue in histopathologial analyses, no fluorescence was shown at the dura tail using the standard operating microscope. Thus, 5-ALA metabolism in this surgically important site remains unknown but needs to be elucidated when further evaluating indications of fluorescence-guided surgery in meningiomas. METHOD: We here present the spatially resolved identification of protoporphyrin IX (PpIX) in sphenoid ridge meningioma cryosections from a patient who underwent fluorescence-guided microsurgery using molecular imaging analysis by matrix-assisted laser desorption/ionization tandem mass spectrometry (MALDI-MS/MS)...
February 15, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29449447/tracers-for-fluorescence-guided-surgery-how-elongation-of-the-polymethine-chain-in-cyanine-dyes-alters-the-pharmacokinetics-of-a-bimodal-c-rgdyk-tracer
#3
Tessa Buckle, Danny M van Willigen, Silvia J Spa, Albertus W Hensbergen, Steffen van der Wal, Clarize M de Korne, Mick M Welling, Henk G van der Poel, James C H Hardwick, Fijs W B van Leeuwen
Objectives: The potential of (receptor-mediated) fluorescence-based image-guided surgery tracers is generally linked to the near-infrared emission profile and good manufacturing production (GMP) availability of fluorescent dyes. Surprisingly, little is known about the critical interaction between the structural composition of the dye and the pharmacokinetics of the tracers. In this study, a bimodal/hybrid tracer design was used to systematically and quantitatively evaluate the influence of elongation of the polymethine chain in a fluorescent cyanine (Cy) dye on the imaging potential of a targeted (RGD-based) tracer...
February 15, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29429940/review-of-novel-sentinel-lymph-node-biopsy-techniques-in-breast-cancer-patients-treated-with-neoadjuvant-chemotherapy
#4
REVIEW
Yeliz Emine Ersoy, Huseyin Kadioglu
Breast cancer patients who present with nodal metastasis receive neoadjuvant chemotherapy (NAC) with increasing frequency and can have complete pathologic response after treatment. In this clinical scenario, sentinel node mapping and biopsy are gaining acceptance instead of axillary dissection to avoid morbidity. Biopsy proven positive lymph nodes must be reliably excised and examined after NAC to further decrease the false negativity rate of sentinel lymph node (SLN) surgery. The standard method for axillary staging in breast cancer patients even after NAC is SLN biopsy (SLNB) with a radioisotope, blue dye, or both (dual technique)...
January 31, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29408716/scanning-fiber-endoscope-improves-detection-of-5-ala-induced-protoporphyrin-ix-fluorescence-at-the-boundary-of-infiltrative-glioma
#5
Evgenii Belykh, Eric J Miller, Danying Hu, Nikolay L Martirosyan, Eric C Woolf, Adrienne C Scheck, Vadim A Byvaltsev, Peter Nakaji, Leonard Y Nelson, Eric J Seibel, Mark C Preul
OBJECTIVE: Fluorescence-guided surgery with protoporphyrin IX (PpIX) as a photodiagnostic marker is gaining acceptance for resection of malignant gliomas. Current wide-field imaging technologies do not have sufficient sensitivity to detect low PpIX concentrations. We evaluated a scanning fiber endoscope (SFE) for detection of PpIX fluorescence in gliomas and compared it with an operating microscope (OPMI) equipped with fluorescence module and a benchtop confocal laser scanning microscope (CLSM)...
January 31, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29388770/a-dual-reporter-iodinated-labeling-reagent-for-cancer-positron-emission-tomography-imaging-and-fluorescence-guided-surgery
#6
Zhi Lu, Truc Thuy Pham, Vineeth Rajkumar, Zilin Yu, R Barbara Pedley, Erik Årstad, John Maher, Ran Yan
The combination of early diagnosis and complete surgical resection offers the greatest prospect of curative cancer treatment. An iodine-124/fluorescein-based dual-modality labeling reagent, 124I-Green, constitutes a generic tool for one-step installation of a positron emission tomography (PET) and a fluorescent reporter to any cancer-specific antibody. The resulting antibody conjugate would allow both cancer PET imaging and intraoperative fluorescence-guided surgery. 124I-Green was synthesized in excellent radiochemical yields of 92±5% (n=4) determined by HPLC with an improved one-pot three-component radioiodination reaction...
February 1, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29374688/fluorescence-guided-surgery-with-splenic-preservation-prevents-tumor-recurrence-in-an-orthotopic-nude-mouse-model-of-human-pancreatic-cancer
#7
Ho Kyoung Hwang, Chang Moo Kang, Sung Hwan Lee, Takashi Murakami, Tasuku Kiyuna, Se Hoon Kim, Robert M Hoffman, Michael Bouvet
AIM: The purpose of this study was to investigate whether splenectomy influences tumor recurrence after fluorescence-guided surgery (FGS) in an orthotopic nude-mouse model of pancreatic cancer. MATERIALS AND METHODS: Green fluorescence protein (GFP)-labeled human pancreatic cancer cells (MiaPaCa2-GFP) were subcutaneously injected into the flanks of nude mice. Subcutaneous tumors were harvested and surgical orthotopic implantation (SOI) was performed in the tail of the pancreas with small tumor fragments...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29373718/the-aberrant-splicing-of-baf45d-links-splicing-regulation-and-transcription-in-glioblastoma
#8
Guillermo Aldave, Marisol Gonzalez-Huarriz, Angel Rubio, Juan Pablo Romero, Datta Ravi, Belén Miñana, Mar Cuadrado-Tejedor, Ana García-Osta, Roeland Verhaak, Enric Xipell, Naiara Martinez-Vélez, Arlet Acanda de la Rocha, Montserrat Puigdelloses, Marc García-Moure, Miguel Marigil, Jaime Gállego Pérez-Larraya, Oskar Marín-Bejar, Maite Huarte, Maria Stella Carro, Roberto Ferrarese, Cristobal Belda-Iniesta, Angel Ayuso, Ricardo Prat-Acín, Fernando Pastor, Ricardo Díez-Valle, Sonia Tejada, Marta M Alonso
Background: Glioblastoma, the most aggressive primary brain tumor, is a genetically heterogeneous tumor. Alternative spicing (AS) plays a key role in numerous pathologies, including cancer. The objective of our study was to determine whether aberrant AS could play a role in the malignant phenotype of glioma and to understand the mechanism underlying its aberrant regulation. Methods: We obtained surgical samples from patients with glioblastoma who underwent 5-aminolevulinic fluorescence-guided surgery...
January 24, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29372363/tumor-specific-labeling-of-pancreatic-cancer-using-a-humanized-anti-cea-antibody-conjugated-to-a-near-infrared-fluorophore
#9
Thinzar M Lwin, Takashi Murakami, Kentaro Miyake, Paul J Yazaki, John E Shivley, Robert M Hoffman, Michael Bouvet
BACKGROUND/PURPOSE: Development of a humanized fluorophore-conjugated antibody that can improve contrast for fluorescence-guided oncologic surgeries. METHODS: BxPC-3-GFP pancreatic cancer cells were injected into flanks of nude mice. Fragments of subcutaneous tumors were grafted onto the pancreatic tail of recipient mice to create orthotopic xenograft models of pancreatic cancer. After tumors developed for 4 weeks, a humanized anti-carcinoembryonic antigen antibody conjugated to an 800 nm near-infrared fluorescent dye (hM5A-IR800) was injected intravenously...
January 25, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29359237/furthering-precision-in-sentinel-node-navigational-surgery-for-oral-cancer-a-novel-triple-targeting-system
#10
Manish Chand, Deborah S Keller, Laurence Devoto, Mark McGurk
To describe an innovative sentinel lymph node (SLN) guidance approach using a radionuclide tracer, 3D augmented reality-guided imaging, and near infrared (NIR) fluorescence over-lay imaging with hand-held probes to optimize accuracy, efficiency, and precise navigation for sentinel node (SN) localization in head and neck cancer. In a cT1N0M0 squamous cell carcinoma of the tongue, pre-operative radionuclide lymphoscintigraphy was performed with a sentinel node-specific radiolabeled tracer. Intraoperatively, a 3D hand-held augmented reality (AR) scanning SPECT probe assessed concordance of the SN with pre-operative SPECT-CT images...
January 22, 2018: Journal of Fluorescence
https://www.readbyqxmd.com/read/29357709/blood-brain-barrier-disruption-sodium-fluorescein-and-fluorescence-guided-surgery-of-gliomas
#11
Yan Xiang, Xiao-Peng Zhu, Jian-Nong Zhao, Guo-Hao Huang, Jun-Hai Tang, Huan-Ran Chen, Lei Du, Dong Zhang, Xue-Feng Tang, Hui Yang, Sheng-Qing Lv
PURPOSE: Sodium fluorescein (SF) is an ideal dye for intraoperative guided-resection of high-grade gliomas (HGGs). However, it is not well understood whether the SF-guided technique is suitable for different grades of gliomas, and the correlation between fluorescence and pathology is also not yet clear. MATERIALS AND METHODS: In this study, we investigated 28 patients, including 23 patients with HGG and 5 patients with low-grade glioma (LGG). All patients were treated using the SF-guided technique on a Pentero 900 microscope (Carl Zeiss, Oberkochen, Germany)...
January 22, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29355914/intraoperative-imaging-technology-to-maximise-extent-of-resection-for-glioma
#12
REVIEW
Michael D Jenkinson, Damiano Giuseppe Barone, Andrew Bryant, Luke Vale, Helen Bulbeck, Theresa A Lawrie, Michael G Hart, Colin Watts
BACKGROUND: Extent of resection is considered to be a prognostic factor in neuro-oncology. Intraoperative imaging technologies are designed to help achieve this goal. It is not clear whether any of these sometimes very expensive tools (or their combination) should be recommended as standard care for people with brain tumours. We set out to determine if intraoperative imaging technology offers any advantage in terms of extent of resection over standard surgery and if any one technology was more effective than another...
January 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29350498/glioma-targeted-delivery-of-a-theranostic-liposome-integrated-with-quantum-dots-superparamagnetic-iron-oxide-and-cilengitide-for-dual-imaging-guiding-cancer-surgery
#13
He-Lin Xu, Jing-Jing Yang, De-Li ZhuGe, Meng-Ting Lin, Qun-Yan Zhu, Bing-Hui Jin, Meng-Qi Tong, Bi-Xin Shen, Jian Xiao, Ying-Zheng Zhao
Herein, a theranostic liposome (QSC-Lip) integrated with superparamagnetic iron oxide nanoparticles (SPIONs) and quantum dots (QDs) and cilengitide (CGT) into one platform is constructed to target glioma under magnetic targeting (MT) for guiding surgical resection of glioma. Transmission electron microscopy and X-ray photoelectron spectroscopy confirm the complete coencapsulation of SPIONs and QDs in liposome. Besides, CGT is also effectively encapsulated into the liposome with an encapsulation efficiency of ∼88...
January 19, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29344305/a-tumor-activatable-theranostic-nanomedicine-platform-for-nir-fluorescence-guided-surgery-and-combinatorial-phototherapy
#14
Xiaoning Li, Canan Schumann, Hassan A Albarqi, Christopher J Lee, Adam W G Alani, Shay Bracha, Milan Milovancev, Olena Taratula, Oleh Taratula
Fluorescence image-guided surgery combined with intraoperative therapeutic modalities has great potential for intraoperative detection of oncologic targets and eradication of unresectable cancer residues. Therefore, we have developed an activatable theranostic nanoplatform that can be used concurrently for two purposes: (1) tumor delineation with real-time near infrared (NIR) fluorescence signal during surgery, and (2) intraoperative targeted treatment to further eliminate unresected disease sites by non-toxic phototherapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29334791/application-of-fluorescence-guided-surgery-to-subsurface-cancers-requiring-wide-local-excision-literature-review-and-novel-developments-toward-indirect-visualization
#15
Kimberley S Samkoe, Brent D Bates, Jonathan T Elliott, Ethan LaRochelle, Jason R Gunn, Kayla Marra, Joachim Feldwisch, Dipak B Ramkumar, David F Bauer, Keith D Paulsen, Brian W Pogue, Eric R Henderson
The excision of tumors by wide local excision is challenging because the mass must be removed entirely without ever viewing it directly. Positive margin rates in sarcoma resection remain in the range of 20% to 35% and are associated with increased recurrence and decreased survival. Fluorescence-guided surgery (FGS) may improve surgical accuracy and has been utilized in other surgical specialties. ABY-029, an anti-epidermal growth factor receptor Affibody molecule covalently bound to the near-infrared fluorophore IRDye 800CW, is an excellent candidate for future FGS applications in sarcoma resection; however, conventional methods with direct surface tumor visualization are not immediately applicable...
January 2018: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/29333929/efficacy-of-an-imaging-device-at-identifying-the-presence-of-bacteria-in-wounds-at-a-plastic-surgery-outpatients-clinic
#16
Ellen L Blackshaw, Steven L A Jeffery
OBJECTIVE: Current standard diagnostic practice of bacterial infections by visual inspection under white light is subjective, and microbiological sampling is suboptimal due to high false negative rates and the lengthy time needed for culture results to arrive. The MolecuLight i:X Imaging Device attempts to combat the issues faced in standard practice by providing a non-contact, real-time method of visualising bacteria within wounds. Our aim was to test this imaging device in a series of patients...
January 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29329549/near-infrared-dye-marking-for-thoracoscopic-resection-of-small-sized-pulmonary-nodules-comparison-of-percutaneous-and-bronchoscopic-injection-techniques
#17
Takashi Anayama, Kentaro Hirohashi, Ryohei Miyazaki, Hironobu Okada, Nobutaka Kawamoto, Marino Yamamoto, Takayuki Sato, Kazumasa Orihashi
BACKGROUND: Minimally invasive video-assisted thoracoscopic surgery for small-sized pulmonary nodules is challenging, and image-guided preoperative localisation is required. Near-infrared indocyanine green fluorescence is capable of deep tissue penetration and can be distinguished regardless of the background colour of the lung; thus, indocyanine green has great potential for use as a near-infrared fluorescent marker in video-assisted thoracoscopic surgery. METHODS: Thirty-seven patients with small-sized pulmonary nodules, who were scheduled to undergo video-assisted thoracoscopic wedge resection, were enrolled in this study...
January 12, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29312629/fluorescence-guided-surgery-for-cancer-patients-a-proof-of-concept-study-on-human-xenografts-in-mice-and-spontaneous-tumors-in-pets
#18
Eliane Mery, Muriel Golzio, Stephanie Guillermet, Didier Lanore, Augustin Le Naour, Benoît Thibault, Anne Françoise Tilkin-Mariamé, Elizabeth Bellard, Jean Pierre Delord, Denis Querleu, Gwenael Ferron, Bettina Couderc
Surgery is often the first treatment option for patients with cancer. Patient survival essentially depends on the completeness of tumor resection. This is a major challenge, particularly in cases of peritoneal carcinomatosis, where tumors are widely disseminated in the large peritoneal cavity. Any development to help surgeons visualize these residual cells would improve the completeness of the surgery. For non-disseminated tumors, imaging could be used to ensure that the tumor margins and the draining lymph nodes are free of tumor deposits...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29303061/indocyanine-green-fluorescence-imaging-guided-surgery-in-primary-and-metastatic-liver-tumors
#19
Eva Lieto, Gennaro Galizia, Francesca Cardella, Andrea Mabilia, Nicoletta Basile, Paolo Castellano, Michele Orditura, Annamaria Auricchio
BACKGROUND: After surgery for liver tumors, recurrence rates remain high because of residual positive margins or undiagnosed lesions. It has been suggested that detection of hepatic tumors can be obtained with near-infrared fluorescence imaging (FI). Indocyanine green (ICG) has been used with contrasting results. The aims of this study were to explore ICG-FI-guided surgery methodology and to assess its potential applications. MATERIALS AND METHODS: Out of 14 patients with liver tumors, 5 were not operated on, and 9 patients (3 primary and 6 metastatic tumors) underwent surgery...
January 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29298796/development-and-preclinical-validation-of-a-cysteine-knottin-peptide-targeting-integrin-%C3%AE-v%C3%AE-6-for-near-infrared-fluorescent-guided-surgery-in-pancreatic-cancer
#20
Willemieke Sfj Tummers, Richard H Kimura, Lotfi Abou-Elkacem, Alexander L Vahrmeijer, Rutger-Jan Swijnenburg, Juergen K Willmann, Sanjiv S Gambhir
PURPOSE: Intraoperative near-infrared fluorescence (NIRF) imaging could help stratification for the proper primary treatment for patients with pancreatic ductal adenocarcinoma (PDAC), and achieve complete resection since it allows visualization of cancer in real time. Integrin αvβ6, a target specific for PDAC, is present in >90% of patients, and is able to differentiate between pancreatitis and PDAC. A clinically translatable αvβ6-targeting NIRF agent was developed, based on a previously developed cysteine knottin peptide for PET imaging, R01-MG, and validated in preclinical mouse models...
January 3, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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