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agents halogénés

Marcos Fernando Xisto Braga Cavalcanti, Uoston Holder Silva, Ernesto Cesar Pinto Leal-Junior, Rodrigo A B Lopes-Martins, Rodrigo Labat Marcos, Rodney Capp Pallotta, Francesca Diomede, Oriana Trubiani, Natalia De Isla, Lucio Frigo
BACKGROUND: The temporomandibular joint (TMJ) is a structure of the craniofacial complex affected by neurological diseases. Orthopedic and musculoskeletal changes can also cause temporomandibular disorders (TMD) and pain. Low-level laser (LLL) therapy has been studied in the treatment of temporomandibular jaw (TMJ) dysfunction, and controversial results were obtained. OBJECTIVE: The objective of this work was comparing the physiotherapeutic and drug protocol (PDP) to LLL therapy in the treatment of pain associated with TMD...
November 29, 2016: Photomedicine and Laser Surgery
V Cavalli, B G Silva, S B Berger, G Abuna, F C Marson, Cpm Tabchoury, M Giannini
This study aimed to quantify the concentration of hydrogen peroxide into the pulp chamber in the presence or absence of adhesive enamel restorations and to analyze the resin-dentin interface of bleached groups. Bovine incisors (120) were randomly divided into three groups according to enamel treatment (n=40 each): (1) enamel without restoration (control); (2) enamel cavities (3 mm diameter × 1.5 mm depth) restored with a silorane-based (SB) system; or (3) enamel cavities (3 mm diameter × 1.5 mm depth) restored with a dimethacrylate-based (DB) system...
November 28, 2016: Operative Dentistry
Providencia González-Hernández, Manuel Hernández-Padrón, Verónica Pino, Ana M Afonso, Juan H Ayala
A simple and efficient method has been developed for the extraction and determination of sixteen common volatile halogenated disinfection by-products (DBPs) in blending desalinated waters, using headspace solid-phase microextraction and gas chromatography with flame-ionization detection (HS-SPME/GC-FID). The DBPs determined included 4 trihalomethanes, 6 haloacetonitriles and 6 halonitromethanes. After the optimization using factorial designs of the HS-SPME parameters (optimum: carboxen/polydimethylsiloxane (CAR/PDMS) fiber, extraction time of 60 min at 30 °C, pH 7, addition of 40% (w/v) of sodium chloride, and desorption time of 2 min at 250 °C), quantification limits ranged from 3...
November 28, 2016: Environmental Technology
Wafaa Halloum, Ronan Cariou, Gaud Dervilly-Pinel, Farouk Jaber, Bruno Le Bizec
Organophosphate esters (OPEs) are chemical compounds incorporated into materials as flame-proof and/or plasticizing agents. In this work, 13 non-halogenated and 5 halogenated OPEs were studied. Their mass spectra were interpreted and compared in terms of fragmentation patterns and dominant ions via various ionization techniques (electron ionization (EI) and chemical ionization (CI) under vacuum and corona discharge atmospheric pressure chemical ionization (APCI)) on gas chromatography coupled to mass spectrometry (GC-MS)...
November 21, 2016: Journal of Mass Spectrometry: JMS
Mirco Weil, Tobias Meißner, Armin Springer, Mirco Bundschuh, Lydia Hübler, Ralf Schulz, Karen Duis
For in situ remediation of groundwater contaminated by halogenated hydrocarbons Carbo-Iron(®), a composite of microscale activated carbon and nano Fe(0), was developed. Against the background of intended release of Carbo-Iron into the environment in concentrations in the g/L-range, potential ecotoxicological consequences were evaluated in the present study. The nano Fei(0) in Carbo-Iron acts as reducing agent and is oxidized in aqueous systems by chlorinated solvents, groundwater constituents (e.g. dissolved oxygen) and anaerobic corrosion...
December 2016: Aquatic Toxicology
Yong Guo, Ruige Yang, Hui Xu
Introduction of the halogen atom or the acyl group at the C-ring of fraxinellone was investigated. Some unexpected halogenation products were obtained with the different chlorination/bromination reagents, and their possible reaction mechanisms were also proposed. Seven key steric structures of 2a', 2b, 2b', 2c', 3a, 3b, and one isomer (5'α-Cl) of 2a were further confirmed by single-crystal X-ray diffraction. Especially compounds 2a, 2a', 3a and 3c exhibited more potent insecticidal activity than toosendanin...
October 24, 2016: Scientific Reports
Xin-Yue Cheng, Yu-Huan Li, Sheng Tang, Xin Zhang, Yan-Xiang Wang, Sheng-Gang Wang, Jian-Dong Jiang, Ying-Hong Li, Dan-Qing Song
Twenty-eight new 12N-benzenesulfonyl matrinic butane and halogenated 12N-sulfonyl matrinic butane/ethane derivatives were designed, synthesized and evaluated for their anti-coxsakievirus activities against CVB3 taking compound 1 as the lead. SAR analysis indicated the introduction of a fluoro atom on the 1'-position might be helpful for keeping potency. Among them, compound 8a exhibited potential activities against all CVBs with IC50 ranging from 0.69 to 5.14 μM, suggesting a broad-spectrum anti-coxsackievirus B feature...
September 30, 2016: European Journal of Medicinal Chemistry
Michael Wilking, Constantin G Daniliuc, Ulrich Hennecke
The cinchona alkaloid dimer (DHQD)2PHAL has been shown to be a broadly applicable catalyst for asymmetric halogenations. However, this catalyst does not have to be dimeric and a class of monomeric quinidine and quinine-derived catalysts was prepared which shows often superior selectivities in bromolactonisations of terminal alkynoic acids. Mechanistic investigations show that these organocatalysts act as host molecules that can bind carboxylic acid-based substrates as guests with substantial binding constants...
October 11, 2016: Chemistry: a European Journal
Theebaa Anasamy, Chun Keng Thy, Kong Mun Lo, Chin Fei Chee, Swee Keong Yeap, Behnam Kamalidehghan, Lip Yong Chung
This study seeks to investigate the relationship between the structural modification and bioactivity of a series of tribenzyltin complexes with different ligands and substitutions. Complexation with the N,N-diisopropylcarbamothioylsulfanylacetate or isonicotinate ligands enhanced the anticancer properties of tribenzyltin compounds via delayed cancer cell-cycle progression, caspase-dependent apoptosis induction, and significant reduction in cell motility, migration and invasion. Halogenation of the benzyl ring improved the anticancer effects of the tribenzyltin compounds with the N,N-diisopropylcarbamothioylsulfanylacetate ligand...
September 21, 2016: European Journal of Medicinal Chemistry
Nicolaas A P Franken, H Petra Kok, Johannes Crezee, Gerrit W Barendsen
PURPOSE: To evaluate the enhancement effect of two combined radiation-sensitizing agents in mammalian cells at small doses as compared to large doses using the linear-quadratic (LQ) mathematical model. METHODS AND MATERIALS: Data on clonogenic assays concerning the radio-enhancement effects of combined halogenated pyrimidines and hyperthermia or combined cisplatin and hyperthermia, as published in earlier reports, were analyzed according to the LQ-formula: S(D)/S(0) = exp-(αD + βD(2))...
September 2016: International Journal of Radiation Biology
Omar M M Sabry, Douglas E Goeger, Frederick A Valeriote, William H Gerwick
As a result of our efforts to identify bioactive agents from marine algae, we have isolated and identified one new halogenated monoterpene 1 [(-)-(5E,7Z)-348-trichloro-7-dichloromethyl-3-methyl-157-octatriene] in addition to three known compounds (2, 3 and 4) from the red alga Plocamium cartilagineum collected by hand from the eastern coast of South Africa. Compound 1 was found to be active as a cytotoxic agent in human lung cancer (NCI-H460) and mouse neuro-2a cell lines (IC50 4 μg/mL). Two of these compounds (3 and 4) were found to have cytotoxic activity in other cell line assays, especially against human leukaemia and human colon cancers (IC50 1...
September 14, 2016: Natural Product Research
Lokesh P Padhye
This annual review covers the literature published in 2015 on topics related to the occurrence and fate of emerging environmental pollutants in wastewater. Due to the vast amount of literature published on this topic, I have discussed only a fraction of the quality research publications, up to maximum 20 relevant articles per section, due to limitation of space. The abstract search was carried out using Web of Science, and the abstracts were selected based on their relevance. In few cases, full-text articles were referred to better understand new findings...
October 2016: Water Environment Research: a Research Publication of the Water Environment Federation
S Bikorimana, P Lama, A Walser, R Dorsinville, S Anghel, A Mitioglu, A Micu, L Kulyuk
Synthetic two-dimensional transition metal dichalcogenides such as, tungsten disulphide (WS<sub>2</sub>), tungsten diselenide (WSe<sub>2</sub>), molybdenum disulphide (MoS<sub>2</sub>) as well as mixed molybdenum tungsten disulphide (Mo<sub>0.5</sub>W<sub>0.5</sub>S<sub>2</sub>) single crystals were grown by the chemical vapor transport method using halogens (bromine or chlorine) as transport agents. Multi- layer samples were cleaved from the single crystals, and their nonlinear optical (NLO) properties were obtained from both open aperture and closed aperture Z-scan measurements using a picosecond mode-locked Nd: YAG laser operating at a wavelength of 1064 nm, with pulse duration of 25 ps, and 20 Hz repetition rate...
September 5, 2016: Optics Express
Sandeep P Bahekar, Sneha V Hande, Nikita R Agrawal, Hemant S Chandak, Priyanka S Bhoj, Kalyan Goswami, M V R Reddy
Keeping in mind the immense biological potential of chalcones and sulfonamide scaffolds, a library of sulfonamide chalcones has been synthesized and evaluated for in vitro antifilarial assay against human lymphatic filarial parasite Brugia malayi. Experimental evidence showcased for the first time the potential of some sulfonamide chalcones as effective and safe antifilarial lead molecules against human lymphatic filarial parasite B. malayi. Sulfonamide chalcones 4d, 4p, 4q, 4t and 4aa displayed the significantly wide therapeutic window...
August 21, 2016: European Journal of Medicinal Chemistry
Arnaud Steyaert, Patrice Forget, Virginie Dubois, Patricia Lavand'homme, Marc De Kock
STUDY OBJECTIVE: To investigate if the anesthetic/analgesic regimen is associated with the risk of reporting long-term chronic postmastectomy pain (CPMP). DESIGN: Cross-sectional survey SETTING: Academic hospital PATIENTS: A total of 267 women having undergone mastectomy with axillary lymph node dissection between 2003 and 2008 INTERVENTIONS: All patients were contacted between October and December 2012, with a questionnaire asking for persistent pain after surgery and its characteristics...
September 2016: Journal of Clinical Anesthesia
J Díaz-Crespo, Y Vázquez-Mambrilla, F García-Herrera
The increased use of surgery as a treatment or as an alternative for improvement means that we have a larger number of patients in the operating theatre, including those who suffer from rare diseases. Poland Syndrome is a rare congenital disease associated with muscle development. These patients may have a broad spectrum of abnormalities, which include thoracic anomalies, which can alter the ventilatory management at the level of the airway; the possible onset of malignant hyperthermia. This leads the anaesthetist to take certain preventive measures...
August 17, 2016: Revista Española de Anestesiología y Reanimación
(no author information available yet)
This report represents the conclusions of a Joint FAO/WHO Expert Committee convened to evaluate the safety of residues of certain veterinary drugs in food and to recommend maximum levels for such residues in food. The first part of the report considers general principles regarding the evaluation of residues of veterinary drugs within the terms of reference of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), including MRLs for generic fish species, acute reference doses (ARfDs) for veterinary drugs, an approach for dietary exposure assessment of compounds used for multiple purposes (i...
2016: World Health Organization Technical Report Series
Tim Tremmel, Andreas Puzik, André P Gehring, Franz Bracher
Based on the chemotype of canthin-4-one alkaloids with moderate antimicrobial activity, a collection of variously substituted canthin-4-ones and desaza analogs were synthesized. Key steps in the syntheses were regioselective halogenations of (desaza) canthin-4-one, followed by Pd-catalyzed cross-coupling reactions. The in vitro screening for antimicrobial activity revealed that two 5-substituted canthin-4-ones (3-pyridyl, 2-bromophenyl) exhibit significant activity against Streptococcus entericus, coupled with high selectivity and the lack of cytotoxicity against mammalian cells...
September 2016: Archiv der Pharmazie
M Golets, M R Shimpi, Y-L Wang, O N Antzutkin, S Glavatskih, A Laaksonen
In the last few decades, ionic liquids (ILs) have gained significant attention as lubricants and lubricant additives due to their polar nature, low vapour pressure and tunable physicochemical properties. In this work, quantum chemistry calculations and atomistic Molecular Dynamics (MD) simulations were employed to predict thermal degradation mechanisms of a potential lubricating agent - the tributyloctylphosphonium bis(oxalato)borate ([P4,4,4,8][BOB]) IL. It was found that the onset of decomposition of the studied IL coincides with a cleavage of the B-O bonds in the [BOB](-) anion...
August 10, 2016: Physical Chemistry Chemical Physics: PCCP
Krzysztof Kuciński, Justyna Szudkowska-Frątczak, Grzegorz Hreczycho
In nearly every total synthesis, silylating agents are employed in synthetic steps to protect sensitive functional groups. A Pt-catalyzed hydrosilylation of various unsaturated substrates to prepare novel symmetrical and unsymmetrical disilazanes is described. The developed synthetic methodology is widely applicable and tolerates all manner of functional groups (e.g., amines, ethers, esters, halogens, silanes, etc.). To demonstrate the value of the described method, mono-substituted 1,1,3,3-tetramethyldisilazanes were further selectively converted to completely new unsymmetrical derivatives...
September 5, 2016: Chemistry: a European Journal
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