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https://www.readbyqxmd.com/read/25226498/an-epidemiologic-survey-of-pediatric-sepsis-in-regional-hospitals-in-china
#1
Yuanyuan Wang, Bo Sun, Hongni Yue, Xiaofei Lin, Bing Li, Xiaochun Yang, Chunming Shan, Yujin Fan, Maotian Dong, Yixing Zhang, Wenlong Lin, Xiaofeng Zuo, Ping Su, Yongbo Heng, Jinzhong Xu, Niranjan Kissoon
OBJECTIVE: To determine the prevalence, treatment, and outcomes of sepsis at regional hospitals in Huai'an, Jiangsu, China. DESIGN: Prospective data registry using a descriptive clinical epidemiologic approach through a collaborative network. SETTING: Pediatric departments in 11 regional city and county referral hospitals serving 843,000 children (exclusive of neonates). SUBJECTS: All admissions (n = 27,836) of patients from 28 days to 15 years old from September 1, 2010, to August 31, 2011...
November 2014: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/24661049/specialist-hospital-study-shows-that-septic-shock-and-drowsiness-predict-mortality-in-children-under-five-with-diarrhoea
#2
Monira Sarmin, Tahmeed Ahmed, Pradip K Bardhan, Mohammod J Chisti
AIM: To evaluate the clinical characteristics and outcome in children hospitalised with diarrhoea, comparing those developed septic shock with those who did not. METHODS: We carried out a retrospective chart review on children aged 0-59 months admitted to the Dhaka Hospital, International Centre for Diarrhoeal Diseases Research, Bangladesh, with diarrhoea between October 2010 and September 2011. They were included if they had severe sepsis defined as tachycardia plus hyperthermia or hypothermia or an abnormal white blood cell count plus poor peripheral perfusion in absence of dehydration...
July 2014: Acta Paediatrica
https://www.readbyqxmd.com/read/24372783/varicella-in-a-paediatric-intensive-care-unit-10-year-review-from-starship-children-s-hospital-new-zealand
#3
Sophie Chien-Hui Wen, Fiona Miles, Brent McSharry, Elizabeth Wilson
AIMS: Varicella is now a vaccine-preventable disease but is generally considered benign, making it a low priority for a funded universal immunisation scheme. We aimed to increase the knowledge of the severity, morbidity and mortality caused by varicella, by a review of cases requiring paediatric intensive care in New Zealand where vaccine is available but not funded. METHODS: This is a retrospective chart review of children admitted to the paediatric intensive care unit (PICU) over a 10-year period (July 2001-July 2011) identified from the PICU database with a primary or secondary code for varicella...
April 2014: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/24016420/tyrosinemia-type-1-a-rare-and-forgotten-cause-of-reversible-hypertrophic-cardiomyopathy-in-infancy
#4
Sarar Mohamed, Mohammed A Kambal, Nasir A Al Jurayyan, Abdulrahman Al-Nemri, Amir Babiker, Rana Hasanato, Abdullah S Al-Jarallah
BACKGROUND: Tyrosinemia type 1 (TT1) is an autosomal recessive disorder caused by deficiency of the enzyme fumarylacetoacetate hydrolase (FAH). TT1 usually presents in infancy with features suggestive of liver disease or with sepsis-like symptoms. CASE PRESENTATION: We report two Saudi siblings with TT1. Case 1 was a male infant who presented at 2 months old with fever, vomiting and refusal of feeding. Examination revealed a sick-looking infant with signs of severe dehydration and hypovolemic shock...
2013: BMC Research Notes
https://www.readbyqxmd.com/read/23944206/a-randomised-controlled-trial-of-plasma-filtration-in-severe-paediatric-sepsis
#5
RANDOMIZED CONTROLLED TRIAL
Elliot J Long, Frank Shann, Gale Pearson, David Buckley, Warwick Butt
OBJECTIVE: To determine whether plasma filtration improves 28-day survival in infants and children with severe sepsis. DESIGN: A multicentre randomised controlled trial. SETTING: Paediatric intensive care units in teaching hospitals. PATIENTS: Forty-eight infants and children with severe sepsis. INTERVENTIONS: Patients were randomly assigned to receive plasma filtration (n = 25) or standard therapy (n = 23) for the treatment of septic shock...
September 2013: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/23812341/evolution-of-haemodynamics-and-outcome-of-fluid-refractory-septic-shock-in-children
#6
Akash Deep, Chulananda D A Goonasekera, Yanzhong Wang, Joe Brierley
BACKGROUND: Maintaining threshold values of cardiac output (CO) and systemic vascular resistance (SVR) when used as part of the American College of Critical Care Medicine (ACCM) haemodynamic protocol improves the outcomes in paediatric septic shock. OBJECTIVE: We observed the evolution of CO and SVR during the intensive care admission of children with fluid-refractory septic shock and report this together with the eventual outcomes. DESIGN: Prospective observational study...
September 2013: Intensive Care Medicine
https://www.readbyqxmd.com/read/23711335/enteroviral-myocarditis-in-neonates
#7
Luregn J Schlapbach, Joerg Ersch, Christian Balmer, René Prêtre, Maren Tomaske, Rosmarie Caduff, Jim Morwood, Sylvio Provenzano, Christian Stocker
Enteroviruses are a leading cause of viral infections in children. While most enteroviral infections are mild and self-limiting, severe disease such as a viral sepsis syndrome, myocarditis, hepatitis and meningoencephalitis may occur. We present two cases of neonatal enteroviral myocarditis. Cardiorespiratory failure occurred in both cases, and severe shock refractory to conventional treatment required support with extracorporeal membrane oxygenation (ECMO). One child with coxsackievirus B3 myocarditis failed to recover and died after 3 weeks on ECMO, while one child could be decannulated successfully after 9 days of ECMO and recovered completely subsequently...
September 2013: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/23361625/surviving-sepsis-campaign-international-guidelines-for-management-of-severe-sepsis-and-septic-shock-2012
#8
R P Dellinger, Mitchell M Levy, Andrew Rhodes, Djillali Annane, Herwig Gerlach, Steven M Opal, Jonathan E Sevransky, Charles L Sprung, Ivor S Douglas, Roman Jaeschke, Tiffany M Osborn, Mark E Nunnally, Sean R Townsend, Konrad Reinhart, Ruth M Kleinpell, Derek C Angus, Clifford S Deutschman, Flavia R Machado, Gordon D Rubenfeld, Steven Webb, Richard J Beale, Jean-Louis Vincent, Rui Moreno
OBJECTIVE: To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. DESIGN: A consensus committee of 68 international experts representing 30 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict of interest policy was developed at the onset of the process and enforced throughout...
February 2013: Intensive Care Medicine
https://www.readbyqxmd.com/read/23353941/surviving-sepsis-campaign-international-guidelines-for-management-of-severe-sepsis-and-septic-shock-2012
#9
R Phillip Dellinger, Mitchell M Levy, Andrew Rhodes, Djillali Annane, Herwig Gerlach, Steven M Opal, Jonathan E Sevransky, Charles L Sprung, Ivor S Douglas, Roman Jaeschke, Tiffany M Osborn, Mark E Nunnally, Sean R Townsend, Konrad Reinhart, Ruth M Kleinpell, Derek C Angus, Clifford S Deutschman, Flavia R Machado, Gordon D Rubenfeld, Steven A Webb, Richard J Beale, Jean-Louis Vincent, Rui Moreno
OBJECTIVE: To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. DESIGN: A consensus committee of 68 international experts representing 30 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict of interest policy was developed at the onset of the process and enforced throughout...
February 2013: Critical Care Medicine
https://www.readbyqxmd.com/read/22753559/adherence-to-pals-sepsis-guidelines-and-hospital-length-of-stay
#10
Raina Paul, Mark I Neuman, Michael C Monuteaux, Elliot Melendez
BACKGROUND AND OBJECTIVES: Few studies have evaluated sepsis guideline adherence in a tertiary pediatric emergency department setting. We sought to evaluate (1) adherence to 2006 Pediatric Advanced Life Support guidelines for severe sepsis and septic shock (SS), (2) barriers to adherence, and (3) hospital length of stay (LOS) contingent on guideline adherence. METHODS: Prospective cohort study of children presenting to a large urban academic pediatric emergency department with SS...
August 2012: Pediatrics
https://www.readbyqxmd.com/read/22392263/epidemiology-and-outcome-of-sepsis-in-a-tertiary-care-picu-of-pakistan
#11
Muhammad Rehan Khan, Prem Kumar Maheshwari, Komal Masood, Farah Naz Qamar, Anwar-Ul Haque
OBJECTIVE: To determine the epidemiology and outcome of sepsis in children admitted in pediatric intensive care unit (PICU) of a tertiary care hospital. METHODS: Retrospective review of children 1 mo to 14 y old, admitted to the PICU with severe sepsis or septic shock from January 2007 through December 2008 was done. Demographic, clinical and laboratory features of subjects were reviewed. The primary outcome was mortality at the time of discharge from PICU. The independent predictors of mortality were modeled using multiple logistic regression...
November 2012: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/21541646/management-of-septic-shock
#12
Rakesh Lodha, Tejo Pratap Oleti, S K Kabra
Septic shock is an important cause of mortality in children with sepsis. The incidence of septic shock is 2-4% of admissions in western pediatric intensive care units and 40%-67% for Indian PICUs. Early goal-directed resuscitation that includes aggressive fluid resuscitation of up to 60 mL/kg as boluses of 20 mL/kg by IV push, to achieve desired heart rates and blood pressure, has emerged as mainstay of treatment in the initial stage. Crystalloids are the preferred fluids, while colloids may be used in some situations...
June 2011: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/21494108/myocardial-depressant-effects-of-interleukin-6-in-meningococcal-sepsis-are-regulated-by-p38-mitogen-activated-protein-kinase
#13
Nazima Pathan, Joanne L Franklin, Hariklia Eleftherohorinou, Victoria J Wright, Cheryl A Hemingway, Simon J Waddell, Michael Griffiths, Jayne L Dennis, David A Relman, Sian E Harding, Michael Levin
OBJECTIVES: Myocardial failure, leading to inotrope-unresponsive shock, is the predominant cause of death in meningococcal and other forms of septic shock. Proinflammatory cytokines released in septic shock are known to have myocardial depressant effects. We previously showed that interleukin 6 is a major myocardial depressant factor in children with meningococcal septicemia. In the current study, we aimed to investigate the mechanisms by which interleukin 6 induces myocardial failure in meningococcal sepsis and to identify potential novel therapeutic targets...
July 2011: Critical Care Medicine
https://www.readbyqxmd.com/read/21076287/persistent-low-microcirculatory-vessel-density-in-nonsurvivors-of-sepsis-in-pediatric-intensive-care
#14
COMPARATIVE STUDY
Anke P C Top, Can Ince, Neelke de Meij, Monique van Dijk, Dick Tibboel
OBJECTIVE: To investigate the time course and predictive value of microvascular alterations in children with severe sepsis. DESIGN: Single-center, prospective observational study. SETTING: Intensive care unit of a level III university children's hospital. PATIENTS: Patients with septic shock, requiring the administration of fluid and vasopressor agents and/or inotropes after the correction of hypovolemia, who were intubated and ventilated, were included...
January 2011: Critical Care Medicine
https://www.readbyqxmd.com/read/20544141/-early-hemodynamic-support-in-septic-shock
#15
Guillermo Kohn Loncarica
Sepsis is the most common cause of death in children. Its adequate management has a significant impact on morbidity and mortality. Pediatricians who take initial contact with these patients play a fundamental role in the chain of actions that start at the Emergency Area and finish in the Intensive Care Unit. In recent years, some strategies have been developed to achieve staggered targets: clinical, hemodynamic, biochemical, and oxygenation. The correct interpretation of each affected component will allow the most appropriate intervention...
June 2010: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/20453704/central-extracorporeal-membrane-oxygenation-for-refractory-pediatric-septic-shock
#16
Graeme MacLaren, Warwick Butt, Derek Best, Susan Donath
OBJECTIVE: To demonstrate positive outcome, to achieve higher flow rates, and to reverse shock more quickly by implementing central extracorporeal membrane oxygenation (ECMO) in children with refractory septic shock. Children hospitalized with sepsis have significant mortality rates. The development of shock is the most important risk factor for death. For children with septic shock refractory to all other forms of therapy, ECMO has been recommended but estimated survival is <50% and the best method of applying the technology is unknown...
March 2011: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/20228689/adjunctive-corticosteroid-therapy-in-pediatric-severe-sepsis-observations-from-the-resolve-study
#17
RANDOMIZED CONTROLLED TRIAL
Jerry J Zimmerman, Mark D Williams
OBJECTIVE: To assess whether corticosteroids, used as adjunctive therapy for pediatric severe sepsis, is associated with improved outcomes. DESIGN: Retrospective cohort study examining the clinical database derived from the RESOLVE (REsearching severe Sepsis and Organ dysfunction in children: a gLobal perspective, F1K-MC-EVBP) trial of activated protein C for pediatric severe sepsis. SETTING: A total of 104 pediatric centers in 18 countries from which data were originally gathered...
January 2011: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/19881184/gap-between-knowledge-and-skills-for-the-implementation-of-the-accm-pals-septic-shock-guidelines-in-india-is-the-bridge-too-far
#18
Indumathy Santhanam, Niranjan Kissoon, S R Kamath, Suchitra Ranjit, Jayanthi Ramesh, Janani Shankar
OBJECTIVE: To determine whether physicians were aware of and had the skills to implement the American College of Critical Care Medicine/Pediatric Advanced Life Support Course septic shock protocol. DESIGN: A cross-sectional questionnaire survey. SETTING: Four academic institutions in Chennai, Manipal, Mangalore, and Trivandrum - cities representing the three southern states of Tamil Nadu, Karnataka, and Kerala, respectively, between February and April 2006...
April 2009: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/19325359/clinical-practice-parameters-for-hemodynamic-support-of-pediatric-and-neonatal-septic-shock-2007-update-from-the-american-college-of-critical-care-medicine
#19
Joe Brierley, Joseph A Carcillo, Karen Choong, Tim Cornell, Allan Decaen, Andreas Deymann, Allan Doctor, Alan Davis, John Duff, Marc-Andre Dugas, Alan Duncan, Barry Evans, Jonathan Feldman, Kathryn Felmet, Gene Fisher, Lorry Frankel, Howard Jeffries, Bruce Greenwald, Juan Gutierrez, Mark Hall, Yong Y Han, James Hanson, Jan Hazelzet, Lynn Hernan, Jane Kiff, Niranjan Kissoon, Alexander Kon, Jose Irazuzta, Jose Irazusta, John Lin, Angie Lorts, Michelle Mariscalco, Renuka Mehta, Simon Nadel, Trung Nguyen, Carol Nicholson, Mark Peters, Regina Okhuysen-Cawley, Tom Poulton, Monica Relves, Agustin Rodriguez, Ranna Rozenfeld, Eduardo Schnitzler, Tom Shanley, Saraswati Kache, Sara Skache, Peter Skippen, Adalberto Torres, Bettina von Dessauer, Jacki Weingarten, Timothy Yeh, Arno Zaritsky, Bonnie Stojadinovic, Jerry Zimmerman, Aaron Zuckerberg
BACKGROUND: The Institute of Medicine calls for the use of clinical guidelines and practice parameters to promote "best practices" and to improve patient outcomes. OBJECTIVE: 2007 update of the 2002 American College of Critical Care Medicine Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock. PARTICIPANTS: Society of Critical Care Medicine members with special interest in neonatal and pediatric septic shock were identified from general solicitation at the Society of Critical Care Medicine Educational and Scientific Symposia (2001-2006)...
February 2009: Critical Care Medicine
https://www.readbyqxmd.com/read/19131419/emergency-management-of-children-with-severe-sepsis-in-the-united-kingdom-the-results-of-the-paediatric-intensive-care-society-sepsis-audit
#20
MULTICENTER STUDY
D P Inwald, R C Tasker, M J Peters, S Nadel
OBJECTIVE: To audit current UK practice of the management of severe sepsis in children against the 2002 American College of Critical Care Medicine/Pediatric Advanced Life Support (ACCM-PALS) guideline. DESIGN: Prospective observational study. SETTING: 17 UK paediatric intensive care units (PICUs) and two UK PICU transport services. PARTICIPANTS: 200 children accepted for PICU admission within 12 h of arrival in hospital, whether or not successfully transported to a PICU, with a discharge diagnosis of sepsis or suspected sepsis...
May 2009: Archives of Disease in Childhood
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