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https://www.readbyqxmd.com/read/29041003/depression-in-the-context-of-medical-disorders-new-pharmacological-pathways-revisited
#1
Undine E Lang, Marc Walter
The depressive state has been characterised as one of elevated inflammation, changed cardiovascular parameters and a deranged metabolic situation all of which holds promise for a better understanding and handling of treatment-resistance in affective disorders as well as for future developments in treatment algorithms. In this context several biomarkers are differentially regulated by antidepressant treatment and connected to metabolic, inflammatory, cardiovascular and apoptotic components of the pathophysiology, i...
October 17, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/29033611/stable-ischemic-heart-disease-in-women-current-perspectives
#2
REVIEW
Fatima Samad, Anushree Agarwal, Zainab Samad
Cardiovascular disease is the leading cause of death in women accounting for 1 in every 4 female deaths. Pathophysiology of ischemic heart disease in women includes epicardial coronary artery, endothelial dysfunction, coronary vasospasm, plaque erosion and spontaneous coronary artery dissection. Angina is the most common presentation of stable ischemic heart disease (SIHD) in women. Risk factors for SIHD include traditional risks such as older age, obesity (body mass index [BMI] >25 kg/m(2)), smoking, hypertension, dyslipidemia, cerebrovascular and peripheral vascular disease, sedentary lifestyle, family history of premature coronary artery disease, metabolic syndrome and diabetes mellitus, and nontraditional risk factors, such as gestational diabetes, insulin resistance/polycystic ovarian disease, pregnancy-induced hypertension, pre-eclampsia, eclampsia, menopause, mental stress and autoimmune diseases...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29031392/effects-of-aspirin-in-combination-with-epa-and-dha-on-hdl-c-cholesterol-and-apoa1-exchange-in-individuals-with-type-2-diabetes-mellitus
#3
Robert C Block, Ashley Holub, Amir Abdolahi, Xin M Tu, Shaker A Mousa, Michael N Oda
BACKGROUND/SYNOPSIS: Low-dose aspirin is an effective drug for the prevention of cardiovascular disease (CVD) events but individuals with diabetes mellitus can be subject to 'aspirin resistance'. Thus, aspirin's effect in these individuals is controversial. Higher blood levels of seafood-derived omega-3 polyunsaturated fatty acids (ω3) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) also have beneficial effects in reducing risk of CVD events but few studies have examined the interaction of plasma EPA and DHA with aspirin ingestion...
November 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29024912/how-important-is-aspirin-adherence-when-evaluating-effectiveness-of-low-dose-aspirin
#4
REVIEW
Kate Navaratnam, Zarko Alfirevic, Munir Pirmohamed, Ana Alfirevic
Low-dose aspirin (LDA) is advocated for women at high-risk of pre-eclampsia, providing a modest, 10%, reduction in risk. Cardiology meta-analyses demonstrate 18% reduction in serious vascular events with LDA. Non-responsiveness to aspirin (sometimes termed aspirin resistance) and variable clinical effectiveness are often attributed to suboptimal adherence. The aim of this review was to identify the scope of adherence assessments in RCTs evaluating aspirin effectiveness in cardiology and obstetrics and discuss the quality of information provided by current methods...
October 3, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28969559/genetic-signatures-in-ischemic-stroke-focus-on-aspirin-resistance
#5
Anjana Munshi, Kanika Vasudeva, Pratibha Chaurasia, Sulena Singh
Stroke is one of the leading causes of death. There has been compelling evidence that stroke has a genetic component. Genetic variants not only influence susceptibility to stroke but have also been found to alter the response to pharmacological agents and influence the clinical outcome of the disease. Stroke patients are treated with antiplatelet drugs like aspirin and clopidogrel to prevent a secondary stroke. Inspite the fact that many new antiplatelet drugs have been developed; aspirin is still considered as a golden standard for the antiplatelet therapy...
October 2, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28960680/low-risk-of-treatment-resistance-in-down-syndrome-with-kawasaki-disease
#6
Shinichi Takatsuki, Shohei Ogata, Masahiro Ishii, Masato Yokozawa, Masae Ono, Masako Fujiwara, Hiroyuki Ida, Hideki Motomura, Hiroyuki Moriuchi, Mio Taketazu, Yoichi Kawamura, Tatsuya Kawano, Tatsuro Izumi, Junko Shiono, Shiro Tsuchiya, Keiji Tsuchiya, Terufumi Goushi, Fukiko Ichida, Tsutomu Saji
BACKGROUND: Japanese nationwide survey reported that Down syndrome (DS) is less-frequently occurring comorbidity in Kawasaki disease (KD). Although altered immune responses are frequently observed in DS, no studies have focused treatment response and risk for coronary artery abnormalities (CAAs) in DS with KD. The aim of this study was to evaluate clinical manifestations, treatment response and proportion of CAAs in DS with KD. METHODS: We retrospectively reviewed the medical records of DS with KD from 2005 through 2012...
September 27, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28948649/association-of-gpia-and-cox-2-gene-polymorphism-with-aspirin-resistance
#7
Hui Wang, Xiaoxin Sun, Wanli Dong, Xiuying Cai, Yun Zhou, Youtao Zhang, Weijian Jiang, Qi Fang
OBJECTIVE: This study aimed to explore the association between GPIa, COX-2 gene polymorphisms and aspirin resistance in the ischemic stroke patients from the southern part of Jiangsu province. METHODS: In all, 97 patients with acute ischemic stroke were enrolled in the study. GPIa gene polymorphism at 807C>T (rsl126643) locus and COX-2 gene polymorphism at -765G>C (rs20417) locus were genotyped by PCR pyrosequencing technology. Patients were divided into the aspirin sensitivity (AS) group and aspirin resistance (AR) group according to the platelet aggregation rate...
September 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28913709/unprecedented-anticancer-activities-of-organorhenium-sulfonato-and-carboxylato-complexes-against-hormone-dependent-mcf-7-and-hormone-independent-triple-negative-mda-mb-231-breast-cancer-cells
#8
Paul T Wilder, David J Weber, Angela Winstead, Sabreea Parnell, Tiara V Hinton, Monet Stevenson, Dipak Giri, Samira Azemati, Pola Olczak, Brent V Powell, Tijesunimi Odebode, Solomon Tadesse, Yongchao Zhang, Saroj K Pramanik, James M Wachira, Sujan Ghimire, Pumtiwitt McCarthy, Alexis Barfield, Hirendra N Banerjee, Chao Chen, James A Golen, Arnold L Rheingold, Jeanette A Krause, Douglas M Ho, Peter Y Zavalij, Roosevelt Shaw, Santosh K Mandal
Cisplatin and other metal-based drugs often display side effects and tumor resistance after prolonged use. Because rhenium-based anticancer complexes are often less toxic, a novel series of organorhenium complexes were synthesized of the types: XRe(CO)3Z (X = α-diimines and Z = p-toluenesulfonate, 1-naphthalenesulfonate, 2-naphthalenesulfonate, picolinate, nicotinate, aspirinate, naproxenate, flufenamate, ibuprofenate, mefenamate, tolfenamate, N-acetyl-tryptophanate), and their biological properties were examined...
September 14, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28912955/targeting-aspirin-resistance-with-nutraceuticals-a-possible-strategy-for-reducing-cardiovascular-morbidity-and-mortality
#9
EDITORIAL
James J DiNicolantonio, James H O'Keefe, Mark F McCarty
No abstract text is available yet for this article.
2017: Open Heart
https://www.readbyqxmd.com/read/28910305/aspirin-increases-metabolism-through-germline-signalling-to-extend-the-lifespan-of-caenorhabditis-elegans
#10
Xiao-Bing Huang, Xiao-Hui Mu, Qin-Li Wan, Xiao-Ming He, Gui-Sheng Wu, Huai-Rong Luo
Aspirin is a prototypic cyclooxygenase inhibitor with a variety of beneficial effects on human health. It prevents age-related diseases and delays the aging process. Previous research has shown that aspirin might act through a dietary restriction-like mechanism to extend lifespan. To explore the mechanism of action of aspirin on aging, we determined the whole-genome expression profile of Caenorhabditis elegans treated with aspirin. Transcriptome analysis revealed the RNA levels of genes involved in metabolism were primarily increased...
2017: PloS One
https://www.readbyqxmd.com/read/28893489/review-of-aspirin-and-clopidogrel-resistance-in-peripheral-arterial-disease
#11
REVIEW
Mina Guirgis, Peter Thompson, Shirley Jansen
OBJECTIVE: Aspirin resistance (AR) and clopidogrel resistance (CR) are terms used to describe a reduction in the medication's efficacy in inhibiting platelet aggregation despite regular dosing. This review gives context to the clinical role and implications of antiplatelet resistance in peripheral arterial disease (PAD). METHODS: A review of English-language literature on AR and CR in PAD involving human subjects using PubMed and MEDLINE databases was performed in April 2017...
September 8, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28880908/prostacyclin-thromboxane-and-glomerular-filtration-rate-are-abnormal-in-sickle-cell-pregnancy
#12
Opeyemi Abayomi Obilade, Alani Suleimon Akanmu, Fiona Broughton Pipkin, Bosede Bukola Afolabi
BACKGROUND: Pregnancy increases the risk of morbidity and mortality in sickle cell disease. We previously showed pregnant women with sickle cell disease to have a relatively low plasma renin concentration in late pregnancy, associated with a lack of the expected plasma volume expansion. We hypothesized this to be due to increased systemic vascular resistance through an imbalance between the vasodilator prostacyclin and vasoconstrictor thromboxane, associated with decreased glomerular filtration rate (GFR)...
2017: PloS One
https://www.readbyqxmd.com/read/28875481/proteinuria-predicts-resistance-to-antiplatelet-therapy-in-ischemic-stroke
#13
Gemlyn George, Nikul Patel, Cecilia Jang, David Wheeler, Sridhara S Yaddanapudi, Jonathan Dissin, Ramani Balu, Janani Rangaswami
The occurrence of a stroke while on antiplatelet agents presents a therapeutic dilemma. One of the main causes for recurrent strokes is antiplatelet resistance more commonly known as high on treatment platelet reactivity (HTPR). Prior studies have established that proteinuria is associated with HTPR following myocardial infarction. Here, we investigated whether dipstick proteinuria correlates with HTPR in patients presenting with stroke. We performed a retrospective cohort analysis of 102 patients admitted for a recurrent ischemic stroke that had either a VerifyNow aspirin or VerifyNow clopidogrel laboratory test performed to assess platelet reactivity...
September 5, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/28871227/comparative-proteomic-analysis-provides-insight-into-the-key-proteins-as-possible-targets-involved-in-aspirin-inhibiting-biofilm-formation-of-staphylococcus-xylosus
#14
Chang-Geng Xu, Yan-Bei Yang, Yong-Hui Zhou, Mei-Qi Hao, Yong-Zhi Ren, Xiao-Ting Wang, Jian-Qing Chen, Ishfaq Muhammad, Shuai Wang, Di Liu, Xiu-Bo Li, Yan-Hua Li
Staphylococcus xylosus is an opportunistic pathogen that causes infection in humans and cow mastitis. And S. xylosus possesses a strong ability to form biofilms in vitro. As biofilm formation facilitates resistance to antimicrobial agents, the discovery of new medicinal properties for classic drugs is highly desired. Aspirin, which is the most common active component of non-steroidal anti-inflammatory compounds, affects the biofilm-forming capacity of various bacterial species. We have found that aspirin effectively inhibits biofilm formation of S...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28865598/my-approach-to-the-patient-with-cad-and-aspirin-resistance
#15
Deepak L Bhatt
No abstract text is available yet for this article.
October 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28857200/by-inhibiting-pfkfb3-aspirin-overcomes-sorafenib-resistance-in-hepatocellular-carcinoma
#16
Sainan Li, Weiqi Dai, Wenhui Mo, Jingjing Li, Jiao Feng, Liwei Wu, Tong Liu, Qiang Yu, Shizan Xu, Wenwen Wang, Xiya Lu, Qinghui Zhang, Kan Chen, Yujing Xia, Jie Lu, Yingqun Zhou, Xiaoming Fan, Ling Xu, Chuanyong Guo
Hepatocellular carcinoma (HCC) is one of the few cancers with a continuous increase in incidence and mortality. Drug resistance is a major problem in the treatment of HCC. In the present study, two sorafenib-resistant HCC cell lines and a nude mouse subcutaneously tumor model were used to explore the possible mechanisms leading to sorafenib resistance, and to investigate whether aspirin could increase the sensitivity of hepatoma cells to sorafenib. The combination of aspirin and sorafenib resulted in a synergistic antitumor effect against liver tumors both in vitro and in vivo...
August 31, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28842303/aspirin-resistance-are-associated-with-long-term-recurrent-stroke-events-after-ischaemic-stroke
#17
Ning Zhang, Zhenhua Wang, Lihong Zhou
OBJECTIVE: To investigate the prevalent of aspirin resistance (AR) in stroke and its association with recurrent stroke in 214 patients with ischemic stroke who were receiving aspirin before the stroke onset. METHODS: Two hundreds and fourteen acute stroke patients who previously received aspirin therapy (100mg/day for ≥7days) were enrolled. Whole blood samples were collected for platelet aggregation testing. The result is expressed in aspirin reaction units (ARU)...
August 24, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28832762/antidepressant-effects-of-kai-xin-san-in-fluoxetine-resistant-depression-rats
#18
X Z Dong, D X Wang, Y P Lu, S Yuan, P Liu, Y Hu
This study aimed to investigate the antidepressant effect and the mechanism of action of Kai-Xin-San (KXS) in fluoxetine-resistant depressive (FRD) rats. Two hundred male Wistar rats weighing 200±10 g were exposed to chronic and unpredictable mild stresses (CUMS) for 4 weeks and given fluoxetine treatment simultaneously. The rats that did not show significant improvement in behavioral indexes were chosen as the FRD model rats. These rats were randomly divided into four groups: FRD model control; oral fluoxetine and aspirin; oral KXS at a dose of 338 mg·kg-1·day-1; and oral KXS at a dose of 676 mg·kg-1·day-1...
August 17, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28795317/nonsteroidal-anti-inflammatory-drugs-nsaids-inhibit-the-growth-and-reproduction-of-chaetomium-globosum-and-other-fungi-associated-with-water-damaged-buildings
#19
Kelsey Dalmont, Charles L Biles, Heather Konsure, Sujita Dahal, Tyler Rowsey, Matthew Broge, Shubhra Poudyal, Tara Gurung, Sabina Shrestha, Caleb L Biles, Terry Cluck, Alisha Howard
Indoor mold due to water damage causes serious human respiratory disorders, and the remediation to homes, schools, and businesses is a major expense. Prevention of mold infestation of building materials would reduce health problems and building remediation costs. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit yeasts and a limited number of filamentous fungi. The purpose of this research was to determine the possible inhibitory activity of nonsteroidal anti-inflammatory drugs (NSAIDs) on germination, fungal growth, and reproduction of Chaetomium globosum and other important filamentous fungi that occur in water-damaged buildings...
August 9, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28760712/glucose-impairs-aspirin-inhibition-in-platelets-through-a-nad-p-h-oxidase-signaling-pathway
#20
Gennadi Kobzar, Vilja Mardla, Nigulas Samel
Hyperglycemia has been suggested to play a role in the increased platelet resistance to antiplatelet therapy in patients with diabetes mellitus. Exposure to high glucose impairs platelet inhibition by aspirin. It has been found that antioxidant agents reduce the effect of glucose, confirming the involvement of reactive oxygen species (ROS) in the effect of glucose. The aim of the study was to examine the mechanism of ROS increase by high glucose in aspirin-treated platelets. Platelet aggregation was measured by the optical method, and the production of ROS was detected using luminol-dependent horseradish peroxidase-enhanced chemiluminescence...
July 2017: Prostaglandins & Other Lipid Mediators
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